Page last updated: 2024-08-21

d-alpha tocopherol and fluorouracil

d-alpha tocopherol has been researched along with fluorouracil in 30 studies

Research

Studies (30)

TimeframeStudies, this research(%)All Research%
pre-19906 (20.00)18.7374
1990's7 (23.33)18.2507
2000's6 (20.00)29.6817
2010's11 (36.67)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K1
Rees, RB1
Hobara, N; Watanabe, A1
Fujikawa, T; Fukushima, M; Kato, T; Nishida, K; Ota, K; Yamanaka, N1
Diaz-Rubio, E; Gonzalez Larriba, JL; Martin-Jimenez, M; Sangro, B1
Hikasa, Y; Inamoto, T; Kan, N; Ohgaki, K; Yasunaga, T1
Bruckner, H; Waxman, S1
Kouri, M; Kuitunen, T; Nyandoto, P; Pyrhönen, S1
Shyamala Devi, CS; Subramaniam, S1
ElAttar, TM; Virji, AS1
Kastan, MB1
Beauchamp, RD; Brockman, JA; Chinery, R; Coffey, RJ; Peeler, MO; Shyr, Y1
Gordon, D1
Dintaman, JM; Silverman, JA1
Lawrence, N1
Adeyemo, D; Imtiaz, F; Lowdell, M; Toffa, S; Wickremasinghe, RG; Winslet, M1
Beauchamp, RD; Blanke, CD; Chinery, R; Coffey, R; Johnson, DH; Leach, SD; Morrow, J; Rothenberg, M; Shyr, Y; Stipanov, M1
Erkisi, M; Kara, IO; Sahin, B1
Hildebrand, J1
Dvorák, J; Hyspler, R; Kalábová, H; Kasparová, M; Krcmová, L; Melichar, B; Solichová, D; Urbánek, L1
Hyspler, R; Kalábová, H; Kasparová, M; Krcmová, L; Malírová, E; Melichar, B; Melicharová, K; Pecka, M; Solichová, D1
Basso, D; Bozzato, D; Fadi, E; Fogar, P; Greco, E; Moz, S; Navaglia, F; Padoan, A; Pedrazzoli, S; Plebani, M; Zambon, CF1
Banu, N; Bilal, N; Hasan, S; Khan, F; Khan, HY; Mansoor, T; Sharma, S; Suhail, N1
Fong, CW; Kumar, AP; Li, F; Manu, KA; Ramachandran, L; Sethi, G; Shanmugam, MK; Tan, P1
Fu, Q; Liu, F; Racette, K; Ramishetti, S; Tang, J; Wang, D; Wang, Y1
Fallon, JK; Fu, Q; He, Z; Liu, D; Liu, F; Ma, Y; Wang, D; Wang, Y; Yang, X1
Akgün-Dar, K; Arslan, M; Bilgiç, S; Çetin, B; Engin, KN; Erdem-Kuruca, S; Gürel, E; Karadenizli, S; Yemisci, B1
Al-Asmari, AK; Al-Asmari, SA; Al-Omani, S; Al-Rawi, A; Khan, AQ1
Fang, H; Han, L; Liang, S; Liu, Y; Mu, S; Wang, T; Yin, X; Zhang, N1

Reviews

4 review(s) available for d-alpha tocopherol and fluorouracil

ArticleYear
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
    Drug discovery today, 2016, Volume: 21, Issue:4

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk

2016
Newer treatment in dermatology.
    Southern medical journal, 1975, Volume: 68, Issue:11

    Topics: Acne Vulgaris; Adrenal Cortex Hormones; Antifungal Agents; Antineoplastic Agents; Carotenoids; Dermatologic Agents; Fluorouracil; Herpesviridae Infections; Humans; Keratolytic Agents; Photosensitivity Disorders; Psoriasis; Skin Diseases; Tretinoin; United States; United States Food and Drug Administration; Vitamin E; Vitiligo

1975
New and emerging treatments for photoaging.
    Dermatologic clinics, 2000, Volume: 18, Issue:1

    Topics: Adult; Ascorbic Acid; Child; Dermabrasion; Fluorouracil; Humans; Laser Therapy; Rhytidoplasty; Skin Aging; Sunscreening Agents; Tretinoin; Vitamin E

2000
Neurological complications of cancer chemotherapy.
    Current opinion in oncology, 2006, Volume: 18, Issue:4

    Topics: Antineoplastic Agents; Capecitabine; Central Nervous System; Deoxycytidine; Fluorouracil; Humans; Magnetic Resonance Imaging; Neoplasms; Neuroprotective Agents; Peripheral Nervous System; Peripheral Nervous System Diseases; Vitamin E

2006

Trials

4 trial(s) available for d-alpha tocopherol and fluorouracil

ArticleYear
Failure of high-dose tocopherol to prevent alopecia induced by doxorubicin.
    The New England journal of medicine, 1986, Oct-02, Volume: 315, Issue:14

    Topics: Adult; Aged; Alopecia; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Clinical Trials as Topic; Cyclophosphamide; Doxorubicin; Female; Fluorouracil; Humans; Middle Aged; Vitamin E

1986
Randomised comparison of fluorouracil, epidoxorubicin and methotrexate (FEMTX) plus supportive care with supportive care alone in patients with non-resectable gastric cancer.
    British journal of cancer, 1995, Volume: 71, Issue:3

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Combined Modality Therapy; Drug Administration Schedule; Epirubicin; Female; Fluorouracil; Humans; Male; Methotrexate; Middle Aged; Neoplasm Metastasis; Palliative Care; Stomach Neoplasms; Vitamin A; Vitamin E

1995
A phase I study of vitamin E, 5-fluorouracil and leucovorin for advanced malignancies.
    Investigational new drugs, 2001, Volume: 19, Issue:1

    Topics: Abdominal Pain; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Diarrhea; Dinoprost; Dose-Response Relationship, Drug; F2-Isoprostanes; Female; Fluorouracil; Humans; Infusions, Intravenous; Leucovorin; Male; Middle Aged; Neoplasms; Neutropenia; Vitamin E

2001
Effect of vitamins C and E on antioxidant status of breast-cancer patients undergoing chemotherapy.
    Journal of clinical pharmacy and therapeutics, 2012, Volume: 37, Issue:1

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Antioxidants; Ascorbic Acid; Breast Neoplasms; Case-Control Studies; Comet Assay; Cyclophosphamide; DNA Damage; Doxorubicin; Female; Fluorouracil; Humans; Middle Aged; Neoplasm Staging; Prospective Studies; Vitamin E

2012

Other Studies

22 other study(ies) available for d-alpha tocopherol and fluorouracil

ArticleYear
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
    Chemical research in toxicology, 2010, Volume: 23, Issue:1

    Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship

2010
Decreased disappearance rate of 1-(2-tetrahydrofuryl)-5-fluorouracil (FT-207) from the blood and its unresponsiveness to tocophreyl nicotinate and indomethacin in patients with primary hepatocellular carcinoma.
    Acta medica Okayama, 1979, Volume: 33, Issue:5

    Topics: Carcinoma, Hepatocellular; Fluorouracil; Humans; Indomethacin; Kinetics; Liver Cirrhosis; Liver Neoplasms; Microsomes, Liver; Nicotinic Acids; Tegafur; Vitamin E

1979
Elevation of serum lipid peroxide level associated with doxorubicin toxicity and its amelioration by [dl]-alpha-tocopheryl acetate or coenzyme Q10 in mouse (doxorubicin, toxicity, lipid peroxide, tocopherol, coenzyme Q10).
    Cancer chemotherapy and pharmacology, 1979, Volume: 3, Issue:4

    Topics: Animals; Doxorubicin; Fluorouracil; Lipid Peroxides; Mice; Time Factors; Ubiquinone; Vitamin E

1979
Protective effect of vitamin E against immunosuppression induced by adriamycin, mitomycin C and 5-fluorouracil in mice.
    Nihon geka hokan. Archiv fur japanische Chirurgie, 1983, Sep-01, Volume: 52, Issue:5

    Topics: Animals; Antibiotics, Antineoplastic; Doxorubicin; Fibrosarcoma; Fluorouracil; Immunity, Cellular; Immunosuppression Therapy; Male; Mice; Mice, Inbred BALB C; Mitomycin; Mitomycins; Sarcoma, Experimental; Vitamin E

1983
The enhancement of 5-fluorouracil anti-metabolic activity by leucovorin, menadione and alpha-tocopherol.
    European journal of cancer & clinical oncology, 1982, Volume: 18, Issue:7

    Topics: Animals; Antimetabolites; Cell Count; Cell Division; Cell Line; Deoxyuridine; DNA, Neoplasm; Dose-Response Relationship, Drug; Drug Interactions; Fluorouracil; Folic Acid; Leucovorin; Leukemia, Erythroblastic, Acute; Mice; Vitamin E; Vitamin K

1982
Vitamin E protects intestinal basolateral membrane from CMF-induced damages in rat.
    Indian journal of physiology and pharmacology, 1995, Volume: 39, Issue:3

    Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Cyclophosphamide; Fluorouracil; Intestinal Mucosa; Lipid Metabolism; Lipid Peroxides; Male; Membranes; Methotrexate; Rats; Rats, Wistar; Thyrotropin; Vitamin E

1995
Inhibition of growth in oral squamous carcinoma cells by cyclopentenone prostaglandins: comparison with chemotherapeutic agents.
    Prostaglandins, leukotrienes, and essential fatty acids, 1997, Volume: 56, Issue:6

    Topics: Antineoplastic Agents; Carcinoma, Squamous Cell; Cell Division; Dinoprostone; Fluorouracil; Humans; Methotrexate; Mouth Neoplasms; Prostaglandin D2; Prostaglandins A; Prostaglandins A, Synthetic; Prostaglandins, Synthetic; Tocopherols; Tumor Cells, Cultured; Vitamin E

1997
To oxidize or not to oxidize?
    Nature medicine, 1997, Volume: 3, Issue:11

    Topics: Antineoplastic Agents; Antioxidants; Apoptosis; CCAAT-Enhancer-Binding Proteins; DNA-Binding Proteins; Doxorubicin; Fluorouracil; G1 Phase; Humans; Nuclear Proteins; Oxidation-Reduction; Proto-Oncogene Proteins p21(ras); Pyrrolidines; Thiocarbamates; Transcription Factors; Tumor Cells, Cultured; Vitamin E

1997
Antioxidants enhance the cytotoxicity of chemotherapeutic agents in colorectal cancer: a p53-independent induction of p21WAF1/CIP1 via C/EBPbeta.
    Nature medicine, 1997, Volume: 3, Issue:11

    Topics: Acetylcysteine; Antineoplastic Agents; Antioxidants; Apoptosis; CCAAT-Enhancer-Binding Proteins; Colorectal Neoplasms; Cyclin-Dependent Kinase Inhibitor p21; Cyclins; DNA-Binding Proteins; Doxorubicin; Drug Interactions; Enzyme Inhibitors; Fluorouracil; Humans; Nuclear Proteins; Pyrrolidines; Thiocarbamates; Transcription Factors; Tumor Cells, Cultured; Tumor Suppressor Protein p53; Vitamin E

1997
Can antioxidants enhance chemotherapy?
    Gastroenterology, 1998, Volume: 114, Issue:2

    Topics: Antioxidants; Apoptosis; Colorectal Neoplasms; Cyclin-Dependent Kinase Inhibitor p21; Cyclins; Drug Synergism; Fluorouracil; Humans; Neoplasm Proteins; Thiocarbamates; Tumor Cells, Cultured; Vitamin E

1998
Inhibition of P-glycoprotein by D-alpha-tocopheryl polyethylene glycol 1000 succinate (TPGS).
    Pharmaceutical research, 1999, Volume: 16, Issue:10

    Topics: 3T3 Cells; Animals; Antimetabolites, Antineoplastic; Antineoplastic Agents, Phytogenic; ATP Binding Cassette Transporter, Subfamily B, Member 1; Blotting, Western; Cell Survival; Coloring Agents; Cyclosporine; Fluorouracil; Immunosuppressive Agents; Mice; Micelles; Paclitaxel; Polyethylene Glycols; Rhodamine 123; Vinblastine; Vitamin E

1999
Antioxidants enhance the susceptibility of colon carcinoma cells to 5-fluorouracil by augmenting the induction of the bax protein.
    Cancer letters, 2001, Mar-10, Volume: 164, Issue:1

    Topics: Acetylcysteine; Antimetabolites, Antineoplastic; Antioxidants; Apoptosis; bcl-2-Associated X Protein; Blotting, Western; Colonic Neoplasms; Drug Interactions; Flow Cytometry; Fluorouracil; Free Radical Scavengers; Humans; Oxidation-Reduction; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Reactive Oxygen Species; Time Factors; Tumor Cells, Cultured; Vitamin E

2001
Palmar-plantar erythrodysesthesia due to docetaxel-capecitabine therapy is treated with vitamin E without dose reduction.
    Breast (Edinburgh, Scotland), 2006, Volume: 15, Issue:3

    Topics: Aged; Antimetabolites, Antineoplastic; Antineoplastic Agents, Phytogenic; Breast Neoplasms; Capecitabine; Carcinoma, Ductal, Breast; Deoxycytidine; Docetaxel; Erythema; Fatal Outcome; Female; Fluorouracil; Foot; Hand; Humans; Middle Aged; Paresthesia; Taxoids; Vitamin E

2006
Intestinal permeability, vitamin A absorption, alpha-tocopherol, and neopterin in patients with rectal carcinoma treated with chemoradiation.
    Medical oncology (Northwood, London, England), 2010, Volume: 27, Issue:3

    Topics: Adenocarcinoma; Aged; alpha-Tocopherol; Antimetabolites, Antineoplastic; Antioxidants; Carbohydrates; Chromatography, Gas; Chromatography, High Pressure Liquid; Combined Modality Therapy; Dietary Carbohydrates; Diterpenes; Female; Fluorouracil; Humans; Intestinal Absorption; Male; Middle Aged; Neopterin; Radiotherapy, High-Energy; Rectal Neoplasms; Retinyl Esters; Vitamin A

2010
Serum homocysteine, cholesterol, retinol, alpha-tocopherol, glycosylated hemoglobin and inflammatory response during therapy with bevacizumab, oxaliplatin, 5-fluorouracil and leucovorin.
    Anticancer research, 2009, Volume: 29, Issue:11

    Topics: Adult; Aged; alpha-Tocopherol; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Combined Chemotherapy Protocols; Atherosclerosis; Bevacizumab; Cholesterol; Colorectal Neoplasms; Female; Fluorouracil; Glycated Hemoglobin; Homocysteine; Humans; Leucovorin; Male; Middle Aged; Organoplatinum Compounds; Vitamin A

2009
Analogs of vitamin E epitomized by alpha-tocopheryl succinate for pancreatic cancer treatment: in vitro results induce caution for in vivo applications.
    Pancreas, 2010, Volume: 39, Issue:5

    Topics: alpha-Tocopherol; Animals; Antineoplastic Agents; Apoptosis; bcl-2 Homologous Antagonist-Killer Protein; bcl-2-Associated X Protein; Cell Line, Tumor; Fibroblasts; Fluorouracil; Humans; Mice; Monocytes; Myoblasts; Pancreatic Neoplasms; Smad4 Protein; Vitamin E

2010
First evidence that γ-tocotrienol inhibits the growth of human gastric cancer and chemosensitizes it to capecitabine in a xenograft mouse model through the modulation of NF-κB pathway.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2012, Apr-15, Volume: 18, Issue:8

    Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; bcl-X Protein; Capecitabine; Cell Line, Tumor; Cell Proliferation; Chromans; Cyclin D1; Cyclooxygenase 2; Deoxycytidine; Disease Models, Animal; Fluorouracil; Gene Expression Regulation, Neoplastic; Humans; Inhibitor of Apoptosis Proteins; Intercellular Adhesion Molecule-1; Ki-67 Antigen; Matrix Metalloproteinase 9; Mice; Mice, Nude; Mitochondria; Neovascularization, Pathologic; NF-kappa B; Platelet Endothelial Cell Adhesion Molecule-1; Proto-Oncogene Proteins c-bcl-2; Receptors, CXCR4; Repressor Proteins; Stomach Neoplasms; Survivin; Vascular Endothelial Growth Factor A; Vitamin E; Xenograft Model Antitumor Assays

2012
Multifunctional nanoparticles based on a single-molecule modification for the treatment of drug-resistant cancer.
    Molecular pharmaceutics, 2013, Apr-01, Volume: 10, Issue:4

    Topics: Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cell Line, Tumor; Drug Design; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Flow Cytometry; Fluorouracil; Humans; Hydrolysis; Models, Chemical; Nanoparticles; Neoplasms; Paclitaxel; Polyethylene Glycols; Rhodamine 123; Vitamin E

2013
Combinational delivery of hydrophobic and hydrophilic anticancer drugs in single nanoemulsions to treat MDR in cancer.
    Molecular pharmaceutics, 2014, Aug-04, Volume: 11, Issue:8

    Topics: Adenosine Triphosphatases; Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Cell Cycle; Cell Line, Tumor; Drug Delivery Systems; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Emulsions; Female; Fluorouracil; Humans; Hydrophobic and Hydrophilic Interactions; Inhibitory Concentration 50; Mice; Mice, Nude; Nanomedicine; Neoplasm Transplantation; Paclitaxel; Polyethylene Glycols; Skin Neoplasms; Vitamin E

2014
The evaluation of human tenon's fibroblasts and endothelial cell responses to antifibrotics alone and in combination with α-tocopherol.
    Current eye research, 2015, Volume: 40, Issue:1

    Topics: Alkylating Agents; alpha-Tocopherol; Antioxidants; Apoptosis; bcl-2-Associated X Protein; Caspase 3; Cells, Cultured; Cytochromes c; Drug Combinations; Fibroblasts; Flow Cytometry; Fluorouracil; Human Umbilical Vein Endothelial Cells; Humans; Mitomycin; Necrosis; Paclitaxel; Proto-Oncogene Proteins c-bcl-2; Tenon Capsule

2015
Alleviation of 5-fluorouracil-induced intestinal mucositis in rats by vitamin E via targeting oxidative stress and inflammatory markers.
    Journal of complementary & integrative medicine, 2016, Dec-01, Volume: 13, Issue:4

    Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Biomarkers; Cyclooxygenase 2; Fluorouracil; Inflammation; Intestinal Mucosa; Intestine, Small; Lipid Peroxidation; Male; Mucins; Mucositis; NF-kappa B; Nitric Oxide Synthase Type II; Oxidative Stress; Peroxidase; Random Allocation; Rats, Sprague-Dawley; Vitamin E

2016
Unified D-α-Tocopherol 5-Fu/SAHA bioconjugates self-assemble as complex nanodrug for optimized combination therapy.
    Nanomedicine (London, England), 2018, Volume: 13, Issue:11

    Topics: Allografts; alpha-Tocopherol; Animals; Apoptosis; Cell Line, Tumor; Cell Proliferation; Colonic Neoplasms; Combined Modality Therapy; Drug Synergism; Fluorouracil; Mice; Tissue Distribution; Vorinostat

2018