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d-alpha tocopherol and 2,5,7,8-tetramethyl-2-(2'-carboxyethyl)-6-hydroxychroman

d-alpha tocopherol has been researched along with 2,5,7,8-tetramethyl-2-(2'-carboxyethyl)-6-hydroxychroman in 31 studies

Research

Studies (31)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's5 (16.13)18.2507
2000's20 (64.52)29.6817
2010's5 (16.13)24.3611
2020's1 (3.23)2.80

Authors

AuthorsStudies
Brigelius-Flohé, R; Gassmann, B; Leist, M; Petrzika, M; Schultz, M1
Gassmann, B; Petrizka, M; Schönfeld, A; Schultz, M1
Brigelius-Flohé, R; Elsner, A; Leist, M; Schultz, M1
Brigelius-Flohé, R; Elsner, A; Traber, MG1
Brigelius-Flohé, R; Graf, P; Sies, H; Stahl, W; Wechter, W1
Brigelius-Flohé, R; Elsner, A; Finckh, B; Hübner, C; Kohlschütter, A; Schuelke, M1
Clayton, PT; Muller, DP; Pope, SA1
Leonard, S; Lodge, JK; Ridlington, J; Traber, MG; Vaule, H1
Dunster, C; Galli, F; Kelly, FJ; Lee, R1
Graf, P; Polidori, MC; Radosavac, D; Sies, H; Stahl, W1
Burtin, GE; Clayton, PT; Madge, DJ; Muller, DP; Pope, SA1
Betancor-Fernandez, A; Polidori, MC; Sies, H; Stahl, W1
Hamamura, K; Morinobu, T; Tamai, H; Yoshikawa, S1
Hall, WL; Jeanes, YM; Lodge, JK; Proteggente, AR1
Mazzini, F; Netscher, T; Salvadori, P1
Bray, TM; Bruno, RS; Montine, TJ; Ramakrishnan, R; Traber, MG1
Kelly, FJ; Lee, R; Mudway, IS1
Brigelius-Flohé, R; Ribalta, J; Rock, E; Roob, JM; Tiran, B; Winklhofer-Roob, BM; Wuga, S1
Hamamura, K; Hirahara, F; Iwamoto, T; Morinobu, T; Tamai, H; Yoshikawa, S1
Devereaux, MW; Leonard, SW; Mustacich, DJ; Sokol, RJ; Traber, MG1
Abe, C; Ichikawa, T; Ikeda, S; Uchida, T; Yamashita, K1
Li, YJ; Shaw, HM1
Cheng, CC; Huang, CJ; Kuo, YH; Lee, YJ; Li, YJ; Lin, FJ; Luo, SC; Wein, YS1
Burnett, JR; Clarke, MW; Croft, KD; Hodgson, JM; Ledowski, T; Puddey, IB; Wu, JH1
Leonard, SW; Traber, MG1
Fukuwatari, T; Imai, E; Sano, M; Shibata, K; Tsuji, T1
Abe, C; Ichikawa, T; Ikeda, S; Nomura, S; Uchida, T1
Card, DJ; Farley, SM; Harrington, DJ; Labut, EM; Leonard, SW; Mustacich, DJ; Raines, HF; Traber, MG1
Abel, ED; Lim, CS; Mossalam, M; Soto, J1
Ikeda, S; Nomura, S; Oda, H; Uchida, T1
Bruno, RS; Dey, P; Erdman, JW; Jeon, S; Kuchan, MJ; Neuringer, M; Ranard, KM; Sasaki, GY; Schimpf, KJ1

Trials

4 trial(s) available for d-alpha tocopherol and 2,5,7,8-tetramethyl-2-(2'-carboxyethyl)-6-hydroxychroman

ArticleYear
Synthetic as compared with natural vitamin E is preferentially excreted as alpha-CEHC in human urine: studies using deuterated alpha-tocopheryl acetates.
    FEBS letters, 1998, Oct-16, Volume: 437, Issue:1-2

    Topics: Adult; alpha-Tocopherol; Chromans; Deuterium; Female; Humans; Male; Middle Aged; Propionates; Tocopherols; Vitamin E

1998
Alpha- and gamma-tocotrienols are metabolized to carboxyethyl-hydroxychroman derivatives and excreted in human urine.
    Lipids, 2001, Volume: 36, Issue:1

    Topics: Chromans; Chromatography, High Pressure Liquid; Dietary Supplements; Female; Humans; Kinetics; Male; Propionates; Tocotrienols; Vitamin E

2001
{alpha}-Tocopherol disappearance is faster in cigarette smokers and is inversely related to their ascorbic acid status.
    The American journal of clinical nutrition, 2005, Volume: 81, Issue:1

    Topics: Adult; alpha-Tocopherol; Antioxidants; Ascorbic Acid; Chromans; Female; Humans; Isoprostanes; Male; Oxidative Stress; Propionates; Smoking

2005
Vitamin E supplementation and hepatic drug metabolism in humans.
    Journal of cardiovascular pharmacology, 2009, Volume: 54, Issue:6

    Topics: Adult; alpha-Tocopherol; Area Under Curve; Biotransformation; Chromans; Cytochrome P-450 CYP3A; Dietary Supplements; Double-Blind Method; Drug Interactions; Female; gamma-Tocopherol; Humans; Liver; Male; Midazolam; Middle Aged; Pharmaceutical Preparations; Propionates; Vitamin E

2009

Other Studies

27 other study(ies) available for d-alpha tocopherol and 2,5,7,8-tetramethyl-2-(2'-carboxyethyl)-6-hydroxychroman

ArticleYear
Novel urinary metabolite of alpha-tocopherol, 2,5,7,8-tetramethyl-2(2'-carboxyethyl)-6-hydroxychroman, as an indicator of an adequate vitamin E supply?
    The American journal of clinical nutrition, 1995, Volume: 62, Issue:6 Suppl

    Topics: Biomarkers; Chromans; Drug Stability; Humans; Male; Propionates; Vitamin E

1995
A novel metabolite of RRR-alpha-tocopherol in human urine.
    Die Nahrung, 1993, Volume: 37, Issue:5

    Topics: Chromans; Chromatography, Thin Layer; Gas Chromatography-Mass Spectrometry; Humans; Male; Propionates; Vitamin E

1993
alpha-Carboxyethyl-6-hydroxychroman as urinary metabolite of vitamin E.
    Methods in enzymology, 1997, Volume: 282

    Topics: Animals; Biomarkers; Chromans; Chromatography, Gas; Chromatography, High Pressure Liquid; Gas Chromatography-Mass Spectrometry; Glucuronates; Humans; Hydrolysis; Molecular Structure; Nutrition Assessment; Nutritional Requirements; Propionates; Sensitivity and Specificity; Vitamin E

1997
Quantification of the alpha- and gamma-tocopherol metabolites 2,5,7, 8-tetramethyl-2-(2'-carboxyethyl)-6-hydroxychroman and 2,7, 8-trimethyl-2-(2'-carboxyethyl)-6-hydroxychroman in human serum.
    Analytical biochemistry, 1999, Nov-15, Volume: 275, Issue:2

    Topics: Adult; Chromans; Chromatography, High Pressure Liquid; Electrochemistry; Humans; Middle Aged; Propionates; Reproducibility of Results; Vitamin E

1999
Urinary alpha-tocopherol metabolites in alpha-tocopherol transfer protein-deficient patients.
    Journal of lipid research, 2000, Volume: 41, Issue:10

    Topics: Adolescent; Adult; Ataxia; Carrier Proteins; Chromans; Dietary Supplements; Female; Humans; Male; Mass Spectrometry; Oxidation-Reduction; Pentanoic Acids; Propionates; Vitamin E; Vitamin E Deficiency

2000
A new method for the analysis of urinary vitamin E metabolites and the tentative identification of a novel group of compounds.
    Archives of biochemistry and biophysics, 2000, Sep-01, Volume: 381, Issue:1

    Topics: Animals; Chromans; Deuterium; Gas Chromatography-Mass Spectrometry; Humans; Methods; Oxidative Stress; Propionates; Rats; Reproducibility of Results; Vitamin E

2000
Gas chromatography mass spectrometry analysis of carboxyethyl-hydroxychroman metabolites of alpha- and gamma-tocopherol in human plasma.
    Free radical biology & medicine, 2002, Feb-15, Volume: 32, Issue:4

    Topics: alpha-Tocopherol; Chromans; Chromatography, High Pressure Liquid; Dietary Supplements; Free Radicals; gamma-Tocopherol; Gas Chromatography-Mass Spectrometry; Humans; Propionates; Time Factors; Vitamin E

2002
Tocopherol metabolites 2, 5, 7, 8-tetramethyl-2-(2'-carboxyethyl)-6-hydroxychroman (alpha-CEHC) and 2, 7, 8-trimethyl-2-(2'-carboxyethyl)-6-hydroxychroman (gamma-CEHC) in human serum after a single dose of natural vitamin E.
    European journal of nutrition, 2002, Volume: 41, Issue:3

    Topics: Adult; alpha-Tocopherol; Biological Availability; Chromans; Chromatography, High Pressure Liquid; Female; gamma-Tocopherol; Humans; Isomerism; Male; Propionates; Tocopherols; Vitamin E

2002
Synthesis and analysis of conjugates of the major vitamin E metabolite, alpha-CEHC.
    Free radical biology & medicine, 2002, Sep-15, Volume: 33, Issue:6

    Topics: alpha-Tocopherol; Chromans; Free Radicals; Humans; Mass Spectrometry; Models, Chemical; Propionates; Spectrometry, Mass, Electrospray Ionization; Vitamin E

2002
In vitro antioxidant activity of 2,5,7,8-tetramethyl-2-(2'-carboxyethyl)-6-hydroxychroman (alpha-CEHC), a vitamin E metabolite.
    Free radical research, 2002, Volume: 36, Issue:8

    Topics: Antioxidants; Ascorbic Acid; Chromans; Dose-Response Relationship, Drug; Humans; In Vitro Techniques; Models, Chemical; Nitrogen; Oxygen; Peroxynitrous Acid; Propionates; Spectrometry, Fluorescence; Time Factors; Tyrosine; Vitamin E

2002
Measurement of vitamin E metabolites by high-performance liquid chromatography during high-dose administration of alpha-tocopherol.
    European journal of clinical nutrition, 2003, Volume: 57, Issue:3

    Topics: Adult; alpha-Tocopherol; Antioxidants; Area Under Curve; Chromans; Chromatography, High Pressure Liquid; Humans; Male; Propionates; Vitamin E

2003
Cigarette smokers have decreased lymphocyte and platelet alpha-tocopherol levels and increased excretion of the gamma-tocopherol metabolite gamma-carboxyethyl-hydroxychroman (gamma-CEHC).
    Free radical research, 2004, Volume: 38, Issue:8

    Topics: Adult; alpha-Tocopherol; Antioxidants; Ascorbic Acid; Blood Platelets; Chromans; Dinoprost; Female; Humans; Lymphocytes; Male; Middle Aged; Propionates; Smoking; Uric Acid

2004
First synthesis of rac-(5-2H3)-alpha-CEHC, a labeled analogue of a major vitamin E metabolite.
    The Journal of organic chemistry, 2004, Dec-24, Volume: 69, Issue:26

    Topics: Chromans; Gas Chromatography-Mass Spectrometry; Magnetic Resonance Spectroscopy; Propionates; Vitamin E

2004
Inter- and intra-individual vitamin E uptake in healthy subjects is highly repeatable across a wide supplementation dose range.
    Annals of the New York Academy of Sciences, 2004, Volume: 1031

    Topics: Adult; alpha-Tocopherol; Chromans; Dietary Supplements; Female; Humans; Lactones; Male; Middle Aged; Phenotype; Propionates; Quinones; Reproducibility of Results; Vitamin E

2004
The effect of age on vitamin E status, metabolism, and function: metabolism as assessed by labeled tocopherols.
    Annals of the New York Academy of Sciences, 2004, Volume: 1031

    Topics: Absorption; Adult; Aged; Aging; alpha-Tocopherol; Austria; Chromans; Deuterium; gamma-Tocopherol; Humans; Male; Middle Aged; Nutritional Status; Propionates; Tocopherols; Vitamin E

2004
The effect of gamma-tocopherol administration on alpha-tocopherol levels and metabolism in humans.
    European journal of clinical nutrition, 2005, Volume: 59, Issue:8

    Topics: Adult; alpha-Tocopherol; Antioxidants; Biological Availability; Chromans; Chromatography, High Pressure Liquid; gamma-Tocopherol; Humans; Male; Propionates; Sodium; Vitamin E

2005
Alpha-tocopherol regulation of hepatic cytochrome P450s and ABC transporters in rats.
    Free radical biology & medicine, 2006, Oct-01, Volume: 41, Issue:7

    Topics: alpha-Tocopherol; Animals; ATP-Binding Cassette Transporters; Chromans; Cytochrome P-450 Enzyme System; Injections, Subcutaneous; Liver; Liver Extracts; Male; Models, Molecular; Propionates; Rats; Rats, Sprague-Dawley; Time Factors

2006
Dietary sesame seed decreases urinary excretion of alpha- and gamma-tocopherol metabolites in rats.
    Journal of nutritional science and vitaminology, 2007, Volume: 53, Issue:4

    Topics: alpha-Tocopherol; Animals; Chromans; gamma-Tocopherol; Kidney; Liver; Lung; Male; Propionates; Rats; Rats, Wistar; Seeds; Sesamum

2007
Pregnenolone and dexamethasone, modulators of cytochrome P450-3A, not increase but reduce urinary alpha-CEHC excretion in rats.
    BioFactors (Oxford, England), 2007, Volume: 31, Issue:1

    Topics: alpha-Tocopherol; Animals; Chromans; Cytochrome P-450 CYP3A; Dexamethasone; Ketoconazole; Liver; Male; Pregnenolone Carbonitrile; Propionates; Rats; Rats, Wistar; Thiobarbituric Acid Reactive Substances

2007
Isolation and identification of alpha-CEHC sulfate in rat urine and an improved method for the determination of conjugated alpha-CEHC.
    Journal of agricultural and food chemistry, 2008, Dec-10, Volume: 56, Issue:23

    Topics: alpha-Tocopherol; Animals; Chromans; Chromatography, High Pressure Liquid; Hydrochloric Acid; Hydrolysis; Propionates; Rats; Rats, Wistar

2008
Measurement of the vitamin E metabolites, carboxyethyl hydroxychromans (CEHCs), in biological samples.
    Current protocols in toxicology, 2006, Volume: Chapter 7

    Topics: Animals; Chromans; Chromatography, High Pressure Liquid; Humans; Mass Spectrometry; Propionates; Vitamin E

2006
Association between 24 hour urinary α-tocopherol catabolite, 2,5,7,8-tetramethyl-2(2'-carboxyethyl)-6-hydroxychroman (α-CEHC) and α-tocopherol intake in intervention and cross-sectional studies.
    Asia Pacific journal of clinical nutrition, 2011, Volume: 20, Issue:4

    Topics: Adolescent; Adult; alpha-Tocopherol; Biomarkers; Chromans; Cross-Sectional Studies; Diet Records; Dietary Supplements; Female; Humans; Male; Propionates; Reproducibility of Results; Urinalysis; Young Adult

2011
Tissue distribution of vitamin E metabolites in rats after oral administration of tocopherol or tocotrienol.
    Journal of nutritional science and vitaminology, 2011, Volume: 57, Issue:5

    Topics: 14-alpha Demethylase Inhibitors; Administration, Oral; alpha-Tocopherol; Animals; Biological Transport; Chromans; gamma-Tocopherol; Intestine, Small; Kidney; Liver; Male; Organ Specificity; Propionates; Rats; Rats, Wistar; Tocotrienols; Vitamin E

2011
Vitamin E decreases extra-hepatic menaquinone-4 concentrations in rats fed menadione or phylloquinone.
    Molecular nutrition & food research, 2012, Volume: 56, Issue:6

    Topics: Administration, Oral; alpha-Tocopherol; Animals; ATP-Binding Cassette Transporters; Biotransformation; Chromans; Cytochrome P-450 Enzyme System; Dietary Supplements; Gene Expression Regulation; Injections, Subcutaneous; Liver; Male; Propionates; Random Allocation; Rats; Rats, Sprague-Dawley; RNA, Messenger; Tissue Distribution; Vitamin E; Vitamin K 1; Vitamin K 2; Vitamin K 3

2012
Solid phase synthesis of mitochondrial triphenylphosphonium-vitamin E metabolite using a lysine linker for reversal of oxidative stress.
    PloS one, 2013, Volume: 8, Issue:1

    Topics: Animals; Cattle; Chromans; Lysine; Mass Spectrometry; Mice; Mitochondria; Organophosphorus Compounds; Oxidative Stress; Propionates; Reactive Oxygen Species; Solid-Phase Synthesis Techniques; Vitamin E

2013
γ-Tocopherol Is Metabolized Faster than α-Tocopherol in Young Japanese Women.
    Journal of nutritional science and vitaminology, 2018, Volume: 64, Issue:6

    Topics: Adult; alpha-Tocopherol; Chromans; Chromatography, High Pressure Liquid; Diet; Eating; Female; gamma-Tocopherol; Humans; Japan; Nutritional Status; Propionates; Young Adult

2018
Infant Rhesus Macaque Brain α-Tocopherol Stereoisomer Profile Is Differentially Impacted by the Source of α-Tocopherol in Infant Formula.
    The Journal of nutrition, 2020, 09-01, Volume: 150, Issue:9

    Topics: alpha-Tocopherol; Animal Feed; Animals; Brain Chemistry; Carrier Proteins; Chromans; Diet; Gene Expression Regulation; Humans; Infant; Infant Food; Macaca mulatta; Milk; Propionates

2020