d-ala(2)-mephe(4)-met(0)-ol-enkephalin and methylnaltrexone

d-ala(2)-mephe(4)-met(0)-ol-enkephalin has been researched along with methylnaltrexone* in 1 studies

Other Studies

1 other study(ies) available for d-ala(2)-mephe(4)-met(0)-ol-enkephalin and methylnaltrexone

Article	Year
EEG evidence that morphine and an enkephalin analog cross the blood-brain barrier. Pharmacology, biochemistry, and behavior, 1991, Volume: 40, Issue:4 The ability of naltrexone but not methyl naltrexone to cross the blood-brain barrier (BBB) was used to provide a different approach for the demonstration that opiates can enter the brain. Cortical electroencephalographic (EEG) measurements were made in rats receiving peripheral (IP) injections of naltrexone or methyl naltrexone and morphine or an enkephalin analog [Tyr-D-Ala-Gly-MePhe-Met(O)-ol]. Naltrexone significantly blocked the EEG effects of morphine and the enkephalin analog, but methyl naltrexone failed to do so. The results provide biological evidence that an opiate peptide can cross the BBB to affect the activity of the brain. Topics: Amino Acid Sequence; Animals; Blood-Brain Barrier; D-Ala(2),MePhe(4),Met(0)-ol-enkephalin; Electroencephalography; Male; Molecular Sequence Data; Morphine; MSH Release-Inhibiting Hormone; Naltrexone; Quaternary Ammonium Compounds; Rats; Rats, Inbred Strains	1991

Article

Year

EEG evidence that morphine and an enkephalin analog cross the blood-brain barrier.

Pharmacology, biochemistry, and behavior, 1991, Volume: 40, Issue:4

The ability of naltrexone but not methyl naltrexone to cross the blood-brain barrier (BBB) was used to provide a different approach for the demonstration that opiates can enter the brain. Cortical electroencephalographic (EEG) measurements were made in rats receiving peripheral (IP) injections of naltrexone or methyl naltrexone and morphine or an enkephalin analog [Tyr-D-Ala-Gly-MePhe-Met(O)-ol]. Naltrexone significantly blocked the EEG effects of morphine and the enkephalin analog, but methyl naltrexone failed to do so. The results provide biological evidence that an opiate peptide can cross the BBB to affect the activity of the brain.

Topics: Amino Acid Sequence; Animals; Blood-Brain Barrier; D-Ala(2),MePhe(4),Met(0)-ol-enkephalin; Electroencephalography; Male; Molecular Sequence Data; Morphine; MSH Release-Inhibiting Hormone; Naltrexone; Quaternary Ammonium Compounds; Rats; Rats, Inbred Strains

1991