cytochrome-c-t and tetramethylenedisulfotetramine

To investigate the evidence for the judgement on legal cases of intoxication by tetramine.. Fifty rats given tetramine by lavage were sacrificed at different time after intoxication. The expression of Cyt C was detected by immunohistochemistry, and the reasults were assessed by an image analysis system.. There was a slight expression of Cyt C in control group. In intoxication group the expression of Cyt C increased after the rats were given tetramine for 30 minutes; it reached the peak at 24 hours after intoxication and kept up the level for 3 days, then it began to decrease and returned to the control level in 10 days.. The regular change of Cyt C expression might be a useful sign for assessment in legal cases of intoxication by tetramine.

Topics: Animals; Brain; Bridged-Ring Compounds; Cytochromes c; Female; Immunohistochemistry; Male; Mice; Poisoning; Random Allocation; Rats; Rats, Sprague-Dawley