cytochrome-c-t and sinapinic-acid

Colorectal cancer is the third most lethal and fourth most commonly diagnosed cancer worldwide. Sinapic acid, a derivative of hydroxycinnamic acid, is a promising phytochemical exhibiting numerous pharmacological activities in various systems. It is a substantial chain-breaking antioxidant that operates as a radical scavenger. The aim of this research was to investigate the antiproliferative effect of sinapic acid on the HT-29 cell line besides the mechanisms underlying this activity. The effect of sinapic acid on the viability of HT-29 cell line was investigated using XTT assay. The levels of BCL-2, cleaved caspase 3, BAX, cleaved PARP, and 8-oxo-dG were measured using ELISA. Gamma-H2AX and cytochrome

Topics: 8-Hydroxy-2'-Deoxyguanosine; Apoptosis; bcl-2-Associated X Protein; Caspase 3; Cell Proliferation; Colonic Neoplasms; Coumaric Acids; Cytochromes c; HT29 Cells; Humans; Poly(ADP-ribose) Polymerase Inhibitors