cytochrome-c-t has been researched along with homoeriodictyol* in 1 studies
1 other study(ies) available for cytochrome-c-t and homoeriodictyol
| Article | Year |
|---|---|
Homoeriodictyol protects human endothelial cells against oxidative insults through activation of Nrf2 and inhibition of mitochondrial dysfunction.
Excess intracellular reactive oxygen species (ROS) production is a significant causative factor of many diseases, exemplified by vascular diseases. Mitochondria are a major source of endogenous ROS, which simultaneously induce mitochondrial dysfunction. Nuclear factor-erythroid 2-related factor 2 (Nrf2) represents an important intracellular defense system that protects cells against oxidative insults caused by ROS. Therefore, molecules with the capacities of inducing Nrf2, and preventing mitochondrial dysfunction can inhibit cell apoptosis, and thus are potential drug candidates for the therapy of ROS-mediated vascular diseases. Homoeriodictyol (HE), previously isolated from Viscum articulatum Burm, has been found to be an Nrf2 inducer. In the present study, we investigated its protection on ROS-induced endothelial cell injury using a H Topics: Antioxidants; Apoptosis; Apoptosis Regulatory Proteins; Cell Line; Cytochromes c; Cytoprotection; Dose-Response Relationship, Drug; Flavones; Human Umbilical Vein Endothelial Cells; Humans; Hydrogen Peroxide; Membrane Potential, Mitochondrial; Mitochondria; NF-E2-Related Factor 2; Oxidants; Oxidative Stress; Reactive Oxygen Species; Signal Transduction; Time Factors | 2018 |