cytochrome-c-t and ellagitannin

cytochrome-c-t has been researched along with ellagitannin* in 1 studies

Other Studies

1 other study(ies) available for cytochrome-c-t and ellagitannin

ArticleYear
Cytotoxic effects of ellagitannins isolated from walnuts in human cancer cells.
    Nutrition and cancer, 2014, Volume: 66, Issue:8

    Walnuts contain many bioactive components that may slow cancer growth. A previous report showed that a diet supplemented with walnuts decreased the tumor size formed by MDA-MB-231 human cancer cells injected into nude mice. However, the mechanism of action was never determined. We characterized the effects of a methanol extract prepared from walnuts on human MDA-MB-231, MCF7, and HeLa cells. The extract was cytotoxic to all cancer cells. We identified compounds from the methanol extract that induced this cytotoxicity. The predominant compounds were Tellimagrandin I and Tellimagrandin II, members of the ellagitannin family. We also show a walnut extract decreases the intracellular pH, depolarizes the mitochondrial membrane with release of cytochrome c and phosphatidylserine flipping. The antimitogenic effects of walnut extract were associated with a twofold reduction of mitochondria respiration. These results suggest impairment of mitochondrial function and apoptosis as relevant mechanism of anticancer effects of the walnut extract.

    Topics: 3T3 Cells; Animals; Apoptosis; Cell Line, Tumor; Cyclin B1; Cytochromes c; Diet; HeLa Cells; Humans; Hydrogen-Ion Concentration; Hydrolyzable Tannins; Juglans; MCF-7 Cells; Mice; Mice, Nude; Mitochondria; Nuts; Plant Extracts

2014