cytochrome-c-t and acetyl-acetonate

cytochrome-c-t has been researched along with acetyl-acetonate* in 1 studies

Other Studies

1 other study(ies) available for cytochrome-c-t and acetyl-acetonate

Article	Year
ESI-MS studies of the reactions of novel platinum(II) complexes containing O,O'-chelated acetylacetonate and sulfur ligands with selected model proteins. Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine, 2017, Volume: 30, Issue:4 A group of mixed-ligand Pt(II) complexes bearing acetylacetonate and sulphur ligands were recently developed in the University of Lecce as a new class of prospective anticancer agents that manifested promising pharma-cological properties in preliminary in vitro and in vivo tests. Though modelled on the basis of cisplatin, these Pt(II) complexes turned out to exhibit a profoundly distinct mode of action as they were found to act mainly on non-genomic targets rather than on DNA. Accordingly, we have explored here their reactions with two representative model proteins through an established ESI-MS procedure with the aim to describe their general interaction mechanism with protein targets. A pronounced reactivity with the tested proteins was indeed documented; the nature of the resulting metallodrug-protein interactions could be characterised in depth in the various cases. Preferential binding to protein targets compared to DNA is supported by independent ICP-OES measurements. The implications of these findings are discussed. Topics: Antineoplastic Agents; Binding Sites; Chelating Agents; Cytochromes c; Humans; Hydroxybutyrates; Ligands; Molecular Structure; Organoplatinum Compounds; Pentanones; Protein Binding; Solutions; Spectrometry, Mass, Electrospray Ionization; Ubiquitin	2017

Article

Year

ESI-MS studies of the reactions of novel platinum(II) complexes containing O,O'-chelated acetylacetonate and sulfur ligands with selected model proteins.

Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine, 2017, Volume: 30, Issue:4

A group of mixed-ligand Pt(II) complexes bearing acetylacetonate and sulphur ligands were recently developed in the University of Lecce as a new class of prospective anticancer agents that manifested promising pharma-cological properties in preliminary in vitro and in vivo tests. Though modelled on the basis of cisplatin, these Pt(II) complexes turned out to exhibit a profoundly distinct mode of action as they were found to act mainly on non-genomic targets rather than on DNA. Accordingly, we have explored here their reactions with two representative model proteins through an established ESI-MS procedure with the aim to describe their general interaction mechanism with protein targets. A pronounced reactivity with the tested proteins was indeed documented; the nature of the resulting metallodrug-protein interactions could be characterised in depth in the various cases. Preferential binding to protein targets compared to DNA is supported by independent ICP-OES measurements. The implications of these findings are discussed.

Topics: Antineoplastic Agents; Binding Sites; Chelating Agents; Cytochromes c; Humans; Hydroxybutyrates; Ligands; Molecular Structure; Organoplatinum Compounds; Pentanones; Protein Binding; Solutions; Spectrometry, Mass, Electrospray Ionization; Ubiquitin

2017