cytidine has been researched along with rx-3117 in 9 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 8 (88.89) | 24.3611 |
| 2020's | 1 (11.11) | 2.80 |
| Authors | Studies |
|---|---|
| Ahn, CH; Blaugrund, E; Honeywell, RJ; Jeong, LS; Kathmann, I; Kim, DJ; Lee, YB; Losekoot, N; Ohne, O; Orbach, A; Peters, GJ; Sarkisjan, D; Smid, K; Vecchi, L | 1 |
| Ahn, CH; Fine, T; Kashi, R; Kaye, J; Kim, DJ; Lee, YB; Ohne, O; Peters, GJ; Smid, K; Yang, MY | 1 |
| de Klerk, D; Julsing, JR; Kim, DJ; Lee, YB; Meinsma, R; Peters, GJ; Sarkisjan, D; Smid, K; van Kuilenburg, AB | 1 |
| Kim, DJ; Lee, YB; Peters, GJ; Sarkisjan, D; Smit, E; van den Berg, J | 1 |
| Honeywell, RJ; Kathmann, I; Kristensen, MH; Peters, GJ; Sarkisjan, D | 1 |
| de Klerk, DJ; Honeywell, RJ; Kristensen, MH; Peters, GJ; Sarkisjan, D | 1 |
| Balboni, B; Benaim, E; El Hassouni, B; Giovannetti, E; Heaton, C; Honeywell, RJ; Kim, DJ; Lee, YB; Peters, GJ; Peterson, C; Poore, J; Sarkisjan, D | 1 |
| El Hassouni, B; Funel, N; Giovannetti, E; Infante, J; Mantini, G; Peters, GJ; Ricci, C | 1 |
| Babiker, H; Benaim, E; Borad, MJ; Bullock, AJ; Burhani, N; Elquza, E; Heaton, C; Hicks, LG; Mahadevan, D; Ocean, AJ; Peterson, C; Schlegel, PJ | 1 |
1 review(s) available for cytidine and rx-3117
| Article | Year |
|---|---|
RX-3117 (fluorocyclopentenyl cytosine): a novel specific antimetabolite for selective cancer treatment.
Topics: Administration, Oral; Antimetabolites, Antineoplastic; Biological Availability; Cytidine; Deoxycytidine; Gemcitabine; Humans; Neoplasms; Patient Selection | 2019 |
1 trial(s) available for cytidine and rx-3117
| Article | Year |
|---|---|
A multicenter phase 1/2 study investigating the safety, pharmacokinetics, pharmacodynamics and efficacy of a small molecule antimetabolite, RX-3117, plus nab-paclitaxel in pancreatic adenocarcinoma.
Topics: Adenocarcinoma; Aged; Aged, 80 and over; Albumins; Antineoplastic Combined Chemotherapy Protocols; Area Under Curve; Cytidine; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Half-Life; Humans; Male; Maximum Tolerated Dose; Metabolic Clearance Rate; Middle Aged; Paclitaxel; Pancreatic Neoplasms | 2022 |
7 other study(ies) available for cytidine and rx-3117
| Article | Year |
|---|---|
Metabolism, mechanism of action and sensitivity profile of fluorocyclopentenylcytosine (RX-3117; TV-1360).
Topics: Antineoplastic Agents; Cell Line, Tumor; Cytidine; Cytidine Deaminase; DNA; DNA Modification Methylases; Humans; RNA; Uridine Kinase | 2013 |
A novel cytidine analog, RX-3117, shows potent efficacy in xenograft models, even in tumors that are resistant to gemcitabine.
Topics: Administration, Oral; Animals; Antimetabolites, Antineoplastic; Cell Line, Tumor; Cytidine; Deoxycytidine; Disease Models, Animal; Drug Resistance, Neoplasm; Female; Gemcitabine; HCT116 Cells; HT29 Cells; Humans; Mice; Mice, Nude; Neoplasms; Xenograft Model Antitumor Assays | 2014 |
The Cytidine Analog Fluorocyclopentenylcytosine (RX-3117) Is Activated by Uridine-Cytidine Kinase 2.
Topics: Cell Cycle; Cell Death; Cell Line, Tumor; Cell Proliferation; Cytidine; Down-Regulation; Gene Expression Regulation, Neoplastic; Humans; Phosphorylation; Regression Analysis; Reproducibility of Results; RNA, Messenger; RNA, Small Interfering; Substrate Specificity; Transfection; Uridine Kinase | 2016 |
The radiosensitizing effect of fluorocyclopentenyl-cytosine (RX-3117) in ovarian and lung cancer cell lines.
Topics: Apoptosis; Cell Cycle Checkpoints; Cell Line, Tumor; Cytidine; DNA Damage; Drug Screening Assays, Antitumor; Female; Humans; Lung Neoplasms; Ovarian Neoplasms; Radiation-Sensitizing Agents | 2016 |
Sensitive liquid chromatography mass spectrometry (LC-MS) assay reveals novel insights on DNA methylation and incorporation of gemcitabine, its metabolite difluorodeoxyuridine, deoxyuridine, and RX-3117 into DNA.
Topics: Cell Line, Tumor; Chromatography, Liquid; Cytidine; Deoxycytidine; DNA; DNA Methylation; Floxuridine; Gemcitabine; Humans; Limit of Detection; Mass Spectrometry; RNA | 2016 |
DNA methyltransferases expression in normal tissues and various human cancer cell lines, xenografts and tumors.
Topics: 5-Methylcytosine; Aged; Aged, 80 and over; Animals; Antineoplastic Agents; Cell Line, Tumor; Colorectal Neoplasms; Cytidine; Deoxyuridine; DNA (Cytosine-5-)-Methyltransferases; DNA Methylation; Female; Gene Expression Regulation, Neoplastic; Heterografts; Humans; Male; Mice, Nude; Middle Aged; RNA, Messenger | 2018 |
Uridine Cytidine Kinase 2 as a Potential Biomarker for Treatment with RX-3117 in Pancreatic Cancer.
Topics: Adenocarcinoma; Aged; Antineoplastic Agents; Biomarkers, Tumor; Cell Line, Tumor; Cytidine; Female; Humans; Male; Pancreatic Neoplasms; RNA, Messenger; Uridine Kinase | 2019 |