cytidine has been researched along with pyrimidin-2-one beta-ribofuranoside in 195 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (1.54) | 18.7374 |
| 1990's | 5 (2.56) | 18.2507 |
| 2000's | 61 (31.28) | 29.6817 |
| 2010's | 105 (53.85) | 24.3611 |
| 2020's | 21 (10.77) | 2.80 |
| Authors | Studies |
|---|---|
| Bao, H; Furman, PA; Micolochick Steuer, HM; Murakami, E; Nachman, T; Niu, C; Otto, MJ; Sofia, MA; Wang, P; Whitaker, T | 1 |
| Laliberté, J; Marquez, VE; Momparler, RL | 1 |
| Barchi, JJ; Driscoll, JS; Kelley, JA; Liu, PS; Marquez, VE; Plowman, J | 1 |
| Frick, L; Marquez, VE; Wolfenden, R; Yang, C | 1 |
| Holý, A; Votruba, I; Wightman, RH | 1 |
| Barchi, JJ; Cooney, DA; Ford, H; Hao, Z; Marquez, VE; Taft, C; Weinberg, ZH | 1 |
| Buenger, G; Cooney, DA; Hao, Z; Jeong, LS; Marquez, VE; McCormack, JJ | 1 |
| Carlow, D; Wolfenden, R | 1 |
| Cheng, X; Connolly, BA; Dickman, MJ; Hornby, DP; Hurd, PJ; Zhou, L | 1 |
| Cheng, JC; Gonzales, FA; Greer, S; Jones, PA; Marquez, VE; Matsen, CB; Selker, EU; Ye, W | 1 |
| Caposio, P; Gribaudo, G; Landolfo, S; Maley, F; Riera, L | 1 |
| Foubister, V | 1 |
| Eritja, R; Gargallo, R; Marquez, VE; Tauler, R; Vives, M | 1 |
| Lee, G; Miller, JH; Wolff, E | 1 |
| Cheng, JC; Gonzales, FA; Hu, YG; Jones, PA; Liang, G; Marquez, VE; Weisenberger, DJ; Xu, GL | 1 |
| Christman, JK; Eritja, R; Kelley, JA; Marquez, VE; Vanbemmel, D | 1 |
| Farrar, WL; Hodge, DR; Kelley, JA; Marquez, VE; Plass, C; Pompeia, C; Wu, YZ | 1 |
| Hampton, T | 1 |
| Cheng, JC; Chuang, J; Greer, S; Jones, PA; Liang, G; Marquez, VE; Orntoft, TF; Thykjaer, T; Weisenberger, DJ; Wozniak, C; Yoo, CB | 1 |
| Bradbury, J | 1 |
| Alleman, WG; Aprelikova, ON; Chandramouli, GV; Linehan, WM; Mendoza, A; Rodgers, C; Rogers, C; Sopko, NA; Tabios, RL; Torres-Cabala, C; Vasselli, JR | 1 |
| Almog, R; Maccoll, R; Maley, F; Maley, GF; Van Roey, P | 1 |
| Cheng, JC; Jones, PA; Yoo, CB | 1 |
| Cherry, JM; Farrar, WL; Hodge, DR; Munroe, DJ; Peng, B; Pompeia, C; Thomas, SB; Xiao, W | 1 |
| Bernstein, ML; Lemaire, M; Marquez, VE; Momparler, LF; Momparler, RL | 1 |
| Guo, H; Rao, N; Xu, Q | 1 |
| Agbaria, R; Ben-Kasus, T; Ben-Zvi, Z; Kelley, JA; Marquez, VE | 1 |
| Chen, YF; Covey, JM; D'Argenio, DZ; Egorin, MJ; Eiseman, JL; Glaze, ER; Holleran, JL; Joseph, E; Lyubimov, AV; Parise, RA | 1 |
| Cherry, JC; Farrar, WL; Fox, SD; Hodge, DR; Hurt, EM; Kelley, JA; Munroe, DJ; Peng, B | 1 |
| Burgan, WE; Camphausen, K; Carter, DJ; Cerna, D; Cerra, MA; Dote, H; Hollingshead, MG; Tofilon, PJ | 1 |
| Collins, JM; Cysyk, RL; Klecker, RW | 1 |
| Balch, C; Craft, T; Huang, TH; Nephew, KP; Skalnik, DG; Yan, P; Young, S | 1 |
| Chuang, JC; Jones, PA; Kwan, JM; Li, TW; Liang, G; Yang, AS; Yoo, CB | 1 |
| Desco, M; Esteller, M; Flores, JM; Fraga, MF; Herranz, M; Marquez, V; Martín-Caballero, J; Ruiz-Cabello, J | 1 |
| Agbaria, R; Barchi, JJ; Ben-Kasus, T; Cheng, JC; Jones, PA; Kelley, JA; Marquez, VE; Rao, KV; Yoo, CB | 1 |
| Beumer, JH; Covey, JM; Egorin, MJ; Eiseman, JL; Joseph, E | 1 |
| Agbaria, R; Ben-Kasus, T; Cheng, JC; Jones, PA; Kelley, JA; Marquez, VE; Yoo, CB | 1 |
| Varghese, AJ; Wang, SY | 1 |
| Baylin, SB; Eguchi, S; Esteller, M; Fraga, MF; Fuks, F; Griffioen, AW; Hellebrekers, DM; Hoebers, NT; Jair, KW; van Engeland, M; Viré, E | 1 |
| Brueckner, B; Lyko, F; Musch, T; Stopper, H; Stresemann, C | 1 |
| Brandes, JC; Herman, JG | 1 |
| Farrar, WL; Hurt, EM; Peng, B; Thomas, SB | 1 |
| Corn, PG | 1 |
| Beumer, JH; Covey, JM; D'argenio, DZ; Egorin, MJ; Eiseman, JL; Joseph, E; Parker, RS | 1 |
| Chen, Y; Costa, E; Grayson, DR; Kundakovic, M | 1 |
| Castermans, K; Dings, RP; Fuks, F; Griffioen, AW; Hellebrekers, DM; Hoebers, NT; Mayo, KH; Molema, G; Oude Egbrink, MG; van Engeland, M; Viré, E | 1 |
| Christoph, F; Kempkensteffen, C; Köllermann, J; Krause, H; Miller, K; Schostak, M; Schrader, M; Weikert, S | 1 |
| Dietze, O; Hahn, EG; Hauser-Kronberger, C; Herold, C; Leu, T; Neureiter, D; Ocker, M; Zopf, S | 1 |
| Berger, C; Bernasconi, M; Nadal, D; Rao, SP; Rechsteiner, MP; Sigrist, JA | 1 |
| DeCoteau, JF; Geyer, CR; Lakshimikuttysamma, A; Sanche, SE; Scott, SA; Sheridan, DP | 1 |
| Liu, H; Salford, LG; Sjögren, HO; Widegren, B; Xue, ZT | 1 |
| Echigo, S; Nishimura, K; Rikiishi, H; Shinohara, F; Suzuki, M | 1 |
| Kim, HJ; Lee, WJ | 1 |
| Dowd, CL; Eritja, R; Haworth, IS; Marquez, VE; Sutch, BT; Yang, AS | 1 |
| Bernstein, ML; Lemaire, M; Momparler, LF; Momparler, RL; Raynal, NJ | 1 |
| Haslberger, AG; Karlic, H; Rust, P; Thaler, R | 1 |
| Baubec, T; Mittelsten Scheid, O; Pecinka, A; Rozhon, W | 1 |
| Echigo, S; Endo, M; Rikiishi, H; Shinohara, F; Sugazaki, M; Suzuki, M | 1 |
| Angel, A; Congiatu, C; Gavazza, F; Jones, PA; Marquez, VE; McGuigan, C; Siddiqui, MA; Valente, R; Yoo, CB | 1 |
| Issa, JP | 1 |
| Byun, HM; Chuang, JC; Dubeau, L; Egger, G; Jones, PA; Laird, PW; Long, T; Marquez, VE; Yang, AS; Yoo, CB | 1 |
| Funk, AJ; Lubin, FD; Roth, TL; Sweatt, JD | 1 |
| Batz, C; Claus, R; Flotho, C; Ihde, S; Lübbert, M; Niemeyer, CM; Plass, C; Sandrock, I; Schneider, M | 1 |
| Billam, M; Davidson, NE; Sobolewski, MD | 1 |
| Brank, AS; Christman, JK; Eritja, R; Marquez, VE; van Bemmel, DM | 1 |
| Fu, L; Wang, XX | 1 |
| Arthaud, L; Dombrovsky, A; Ledger, TN; Robichon, A; Tares, S | 1 |
| Selvam, L; Vasilyev, V; Wang, F | 1 |
| Boer, JM; de Lorenzo, P; de Menezes, RX; Pieters, R; Schneider, P; Stam, RW; Stumpel, DJ; Valsecchi, MG; van Roon, EH | 1 |
| Baller, JF; Bloks, VW; Huijkman, NC; Kuipers, F; Lütjohann, D; Plösch, T; van Meer, H; van Straten, EM | 1 |
| Balajee, AS; Meador, JA; Ravanat, JL; Su, Y | 1 |
| Betham, B; Bhagwat, AS; Marquez, VE; Shalhout, S | 1 |
| Assaraf, YG; Bram, EE; Raz, S; Stark, M | 1 |
| Chan, JY; Ho, WK; Man, OY; To, VS; Tsang, CM; Tsang, RK; Tsao, SW; Wei, WI; Wong, TS | 1 |
| Anier, K; Aonurm-Helm, A; Kalda, A; Malinovskaja, K; Zharkovsky, A | 1 |
| Arimondo, PB; Champion, C; Guianvarc'h, D; Guieysse-Peugeot, AL; Jeltsch, A; Jurkowska, RZ; Ponger, L; Sénamaud-Beaufort, C | 1 |
| Chen, M; Giaccone, G; Kaye, FJ; Marquez, VE; Steeg, PS; Voeller, D; Zajac-Kaye, M | 1 |
| Farkas, DL; Gertych, A; Tajbakhsh, J | 1 |
| Imai, T; Miyoshi, E; Moriwaki, K; Narisada, M; Shinzaki, S | 1 |
| Andersen, JB; Conner, EA; Factor, VM; Lee, YH; Marquardt, JU; Raggi, C; Seo, D; Thorgeirsson, SS | 1 |
| de Menezes, RX; den Boer, ML; Lange-Turenhout, EA; Marquez, VE; Pieters, R; Schneider, P; Schotte, D; Seslija, L; Stam, RW; Stumpel, DJ | 1 |
| Lovett, ST; Padgett, DR; Seier, T; Sutera, VA; Toha, N; Zilberberg, G | 1 |
| Morales, JC; Rodríguez-Vargas, JM; Ruiz-Magaña, MJ; Ruiz-Ruiz, C; Saldivia, MA; Schulze-Osthoff, K | 1 |
| Chen, FF; Selvam, L; Wang, F | 1 |
| Andersen, JB; Avital, I; Conner, EA; Factor, VM; Geller, D; Gillen, MC; Holczbauer, A; Kitade, M; Lee, YH; Marquardt, JU; Raggi, C; Seo, D; Thorgeirsson, SS | 1 |
| Borutinskaite, VV; Bruzaite, R; Jonusiene, V; Navakauskiene, R; Savickiene, J; Treigyte, G | 1 |
| Bittová, M; Fajkus, J; Fojtová, M; Majerová, E; Mozgová, I | 1 |
| Bianco-Miotto, T; Butler, LM; Centenera, MM; Chiam, K; Tilley, WD | 1 |
| Lu, Y; Sun, XH; Zhou, P | 2 |
| Barišić, D; Bosnar, MH; Horvat, T; Mužinić, A; Zoldoš, V | 1 |
| Brown, KD; Chen, M; Dyer, LM; Hochwald, SN; Hollingshead, M; Hunter, KW; Kaye, FJ; Marquez, VE; Nawab, A; Shabashvili, D; Steeg, P; Yang, SX; Zajac-Kaye, M | 1 |
| Salford, LG; Sjögren, HO; Widegren, B; Xue, ZT | 1 |
| Chie, EK; Kim, HJ; Kim, IA; Kim, IH; Kim, JH; Young, PD | 1 |
| Clayton, RN; Duong, CV; Farrell, WE; Yacqub-Usman, K | 2 |
| Park, WH; You, BR | 3 |
| van Gurp, TP; Verhoeven, KJ | 1 |
| Biergans, SD; Galizia, CG; Jones, JC; Szyszka, P; Treiber, N | 1 |
| Chen, X; Schroeder, GK; Snider, MJ; Wolfenden, R; Zhou, L | 1 |
| Borutinskaite, VV; Navakauskiene, R; Savickiene, J; Treigyte, G | 1 |
| Fan, L; Liu, X; Lu, Y; Luo, Y; Zhou, P | 1 |
| Haneef, K; Iqbal, H; Jamall, S; Kabir, N; Naeem, N; Salim, A | 1 |
| Graef, AJ; Kartha, RV; Korpela, DM; Modiano, JF; Park, C; Sarver, AL; Steer, CJ; Subramanian, S; Thayanithy, V | 1 |
| Luo, HS; Shen, L; Tan, W; Yu, HG; Zhou, W | 1 |
| Cheng, SY; Kebebew, E; Kim, DW; Kim, WG; Zhang, L; Zhu, X | 1 |
| Huang, G; Liu, H; Luo, S; Wilson, JX; Yan, H; Yu, M; Zhang, X | 1 |
| Aizawa, K; Hata, K; Kato, N; Nakabayashi, K; Nakamura, K; Tanoue, A; Yamauchi, J | 1 |
| Barišić, D; Deželjin, M; Herak Bosnar, M; Horvat, T; Lauc, G; Redžić, I; Zoldoš, V | 1 |
| Gertych, A; Oh, JH; Tajbakhsh, J; Wawrowsky, KA; Weisenberger, DJ | 1 |
| Aguilera, Y; Bedoya, FJ; Fraga, MF; Hmadcha, A; Horrillo, A; Martin, F; Pezzolla, D; Salguero-Aranda, C; Soria, B; Tejedo, JR | 1 |
| Arai, D; Hayakawa, K; Hirosawa, M; Murakami, N; Shiota, K; Tabei, Y; Tanaka, S; Yagi, S | 1 |
| Broggini, M; Ceruti, R; Ganzinelli, M; Geroni, C; Sabatino, MA | 1 |
| Lan, D; Li, J; Ma, L; Wang, Y; Xiong, X; Zhong, J; Zi, X | 1 |
| Albertson, AJ; Buckingham, SC; Davis Haselden, W; Hablitz, JJ; Lubin, FD; Mascia, KL; Ryley Parrish, R | 1 |
| Ericsson, P; Förnvik, K; Jansson, L; Nittby, H; Salford, LG; Sjögren, HO; Skagerberg, G; Strömblad, S; Widegren, B; Xue, Z | 1 |
| Diao, YF; Han, RX; Jin, DI; Li, XX; Lin, T; Naruse, KJ; Oqani, RK | 1 |
| Andrade, AF; Borges, KS; Castro-Gamero, AM; de Paula Queiroz, RG; Moreno, DA; Oliveira, JC; Scrideli, CA; Silveira, VS; Suazo, VK; Tone, LG | 1 |
| Peng, M; Rothstein, SJ; Yaish, MW | 1 |
| Chen, CC; Chuang, SH; Lin, SH; Lin, YT; Shun, CT; Wei, TT; Wu, MS; Yang, PM | 1 |
| Balkin, ER; Bryan, JN; Jia, F; Kumar, SR; Lewis, MR | 1 |
| Andersen, JB; Durkin, M; Factor, VM; Gillen, MC; Holczbauer, A; Marquardt, JU; Raggi, C; Seo, D; Thorgeirsson, SS | 1 |
| Alkamal, I; Fuller, TF; Ikromov, O; Kempkensteffen, C; Krause, H; Magheli, A; Miller, K; Tölle, A | 1 |
| Flis, K; Flis, S; Gnyszka, A | 1 |
| Fares, F; Napso, T | 1 |
| Bredov, DV; Filatova, TS; Kozyrev, SA; Nikitin, PV; Nikitin, VP; Solntseva, SV | 1 |
| Arimany-Nardi, C; Errasti-Murugarren, E; Gorboulev, V; Koepsell, H; Martinez-Picado, J; Minuesa, G; Pastor-Anglada, M | 1 |
| Campbell, RR; Dang, D; Ono, K; Schmidt, BL; Viet, CT; Ye, Y | 1 |
| Levine, A; Sun, Y; Yi, L | 1 |
| Kozyrev, SA; Nikitin, PV; Nikitin, VP; Solntseva, SV | 1 |
| Bryan, JN; Flesner, BK; Kumar, SR | 1 |
| Clayton, RN; Emes, RD; Farrell, WE; Kitchen, MO; Richardson, A; Yacqub-Usman, K | 1 |
| Aulakh, SS; Flinn, BS; Tang, G; Veilleux, RE | 1 |
| Aizawa, K; Hata, K; Hori, N; Htet Aung, K; Nakabayashi, K; Nakamura, K; Tanoue, A; Yamauchi, J | 1 |
| Devine, SE; Hodes, GE; Lenz, KM; Mahurkar, A; McCarthy, MM; Nugent, BM; Russo, SJ; Shetty, AC; Wright, CL | 1 |
| Dock, H; Theodorsson, A; Theodorsson, E | 1 |
| Ai, S; Liu, P; Pang, J; Yin, H | 1 |
| Baubec, T; Díaz, M; Finke, A; Liu, CH; Pecinka, A; Poppenberger, B; Rozhon, W | 1 |
| Gilch, P; Micheel, M; Ryseck, G; Torres Ziegenbein, C | 1 |
| Bonney, PL; Dhawan, D; Fourez, LM; Fulkerson, CM; Jones, DR; Jones, PA; Klaunig, JE; Knapp, DW; Marquez, VE; Wang, Z; Wu, Q | 1 |
| Beers, EP; Brunner, AM; Chanda, B; Jia, X; Zhao, M | 1 |
| Biergans, SD; Claudianos, C; Giovanni Galizia, C; Reinhard, J | 1 |
| D'Souza, S; Kang, TM; Lam, K; Miller, JH; Song, LY; Yeh, P | 1 |
| Bazli, KF; Fazilah, M; Hasan Adli, DS; Khalid, RS; Khan, I; Khanabdali, R; Moghadamtousi, SZ; Mohan, G; Naeem, N; Qazi, RE; Saadat, A; Salim, A; Shamsuddin, SA | 1 |
| Beard, BC; Black, ME; Qiu, S; Ruan, H | 1 |
| Cho, SW; Chu, C; Luo, T; Ma, J; Ma, X; Ni, S; Qi, Z; Tsujimoto, H; Wang, Q; Wang, Y; Wu, N; Zhuang, L | 1 |
| Griffin, PT; Niederhuth, CE; Schmitz, RJ | 1 |
| Ang, J; D'Souza, S; Hong, IL; Luhar, R; Miller, JH; Song, LY; Yung, M | 1 |
| Fan, F; Li, D; Liu, X; Lu, Y; Luo, Y; Wu, J; Zhou, P | 1 |
| Han, H; Ma, B; Wang, J; Wang, S; Yang, Y; Ye, K | 1 |
| Anglard, P; Befort, K; Filliol, D; Fonteneau, M; Romieu, P; Zwiller, J | 1 |
| Dong, P; Hanley, SJ; Ihira, K; Konno, Y; Kudo, M; Sakuragi, N; Suzuki, F; Watari, H; Xiong, Y; Yamada, T; Yue, J | 1 |
| Andrade, AF; Borges, KS; Castro-Gamero, AM; Corrêa, CA; de Oliveira, RS; de Vasconcelos, EJ; Dos Santos Aguiar, S; Geron, L; Neder, L; Scrideli, CA; Suazo, VK; Tone, LG; Yunes, JA | 1 |
| Aizawa, K; Aung, KH; Nakamura, K; Tanoue, A; Yamauchi, J | 1 |
| Butter, R; Linnekamp, JF; Medema, JP; Spijker, R; van Laarhoven, HWM | 1 |
| Bruggeman, E; Castillo-Ruiz, A; Cortes, LR; Forger, NG; Mosley, M; Weathington, J; Xue, B | 1 |
| Hosokawa, M; Iwakawa, S; Kobori, A; Matsubara, E; Matsumura, J; Tanaka, S; Ueda, K | 1 |
| Burgos-Morón, E; Calderón-Montaño, JM; Domínguez, I; Helleday, T; Huertas Castaño, C; López-Lázaro, M; Mateos, S; Orta, ML; Pastor, N | 1 |
| Benner, SA; Kim, HJ | 1 |
| Barrero, JM; Boden, SA; Cavanagh, CA; Finnegan, EJ; Ford, B; Griffin, PT; Hayden, MJ; Pettolino, F; Schmitz, RJ; Swain, SM; Trevaskis, B; Wallace, X; Zhang, P | 1 |
| Hatanaka, K; Kubota, S; Satoh, M; Takemura, Y | 1 |
| Alsalim, H; Jafarpour, F; Nasr-Esfahani, MH; Niasari-Naslaji, A; Tanhaei Vash, N | 1 |
| Fajkus, J; Fojtová, M; Konečná, K; Magdolenová, A; Rájecká, V; Sováková, PP | 1 |
| Cao, H; Fang, X; Li, J; Li, L; Liu, C; Su, W; Sun, S; Tian, S; Wang, H; Wang, Z; Wei, Q | 1 |
| Erlacher, MD; Faserl, K; Fuchs, E; Gasser, C; Höbartner, C; Hoernes, TP; Hüttenhofer, A; Joseph, S; Juen, MA; Kremser, J; Kreutz, C; Lindner, H; Micura, R; Shi, X; Siewert, A; Westhof, E | 1 |
| Chen, J; Li, QY; Luo, YH; Xiao, EH | 1 |
| Chen, G; Chen, Q; Cheng, H; Gu, Z; Hu, Q; Lu, W; Lu, Y; Ruan, H; Wang, J; Wen, D | 1 |
| Brandwein, NJ; Nguyen, PV | 1 |
| Jin, JX; Kim, EH; Kim, GA; Lee, BC; Lee, S; Qasim, M; Taweechaipaisankul, A | 1 |
| Czupryn, A; Deptuła, M; Filipowicz, N; Górnikiewicz, B; Janus, Ł; Kamińska, J; Mieczkowska, A; Mucha, P; Nowicka, E; Peszyńska-Sularz, G; Pikuła, M; Piotrowski, A; Podolak-Popinigis, J; Rekowski, P; Rodziewicz-Motowidło, S; Rogujski, P; Ruczyński, J; Sachadyn, P; Sass, P; Skowron, P; Sosnowski, P; Wardowska, A | 1 |
| Doherty, TS; Keller, SM; Roth, TL | 1 |
| Bible, PW; Ge, X; Hu, X; Lee, RWJ; Li, JJ; Li, Y; Liu, Y; Miao, L; Schewitz-Bowers, LP; Stimpson, M; Wei, L; Wen, X; Yang, L; Zou, Y | 1 |
| Chen, CC; Lin, YT; Luo, CK; Shun, CT; Tang, SP; Tsai, CT; Wei, TT | 1 |
| Dvořák Tomaštíková, E; Ercan, U; Finke, A; Krečmerová, M; Niezgodzki, I; Nowicka, A; Otmar, M; Pecinka, A; Poppenberger, B; Procházková, K; Rozhon, W; Schubert, I; Tokarz, B; Zwyrtková, J | 1 |
| Castillo-Ruiz, A; Cisternas, CD; Cortes, LR; Forger, NG; Golynker, I | 1 |
| Hayes, ML; Santibanez, PI | 1 |
| García-Sanz, R; Gutiérrez, NC; Krzeminski, P | 1 |
| Abd Elmageed, ZY; Ali, HEA; Buttolph, T; Carraway, HE; Cen, Y; Denvir, J; Fan, J; Fandy, TE; Malkaram, SA; Primerano, DA; Shatnawi, A | 1 |
| Kavoosi, F; Sanaei, M | 2 |
| Boonjing, P; Ito, H; Kato, A; Masuta, Y; Nozawa, K | 1 |
| Behjoo, H; Kavoosi, F; Sanaei, M | 1 |
| Anteková, K; Fajkus, J; Fojtová, M; Konečná, K; Sováková, PP | 1 |
| Balderas, R; Cai, S; Chen, Q; Dong, L; Fan, J; Fu, Y; Huang, S; Lai, J; Li, D; Li, Q; Liang, J; Lin, L; Lin, S; Lin, Z; Luo, X; Qian, J; Tian, S; Wang, H; Xu, S; Zhang, X; Zhang, Y; Zhao, H; Zhao, J | 1 |
| Leung, E; Lozano Hernandez, L; Reginald-Opara, JN; Svirskis, D; Tang, M; Wang, H; Wu, Z | 1 |
| Bhutkar, S; Dukhande, V; Patel, K; Patki, M; Saraswat, A | 1 |
| Bucher, E; Julkowska, M; Robertson, M; Roquis, D; Thieme, M; Yu, L | 1 |
| Chen, J; Chen, X; Fang, H; Guo, Z; Hu, Y; Li, Y; Lin, L; Tian, H | 1 |
| Bente, H; Dvořák, P; Filo, J; Finke, A; Ovečka, M; Pecinka, A; Prochazkova, K; Šamaj, J; Tomaštíková, ED | 1 |
| He, G; Li, H; Song, K; Tang, Y; Wang, Z; Xu, G; Xu, W; Yang, X; Yu, B; Zeng, X | 1 |
| Asada, M; Hayashi, H; Takagi, N | 1 |
| Herzig, JW; Husain, M; Khan, I; Mirza, A; Qazi, RE; Salim, A | 1 |
| Cluzet, S; Delaunay, A; Gallusci, P; Garcia, V; Hilbert, G; Kong, J; Lecourieux, D; Lecourieux, F; Maury, S; Renaud, C; Stammitti, L; Teyssier, E; Zehraoui, E | 1 |
5 review(s) available for cytidine and pyrimidin-2-one beta-ribofuranoside
| Article | Year |
|---|---|
Zebularine: a new drug for epigenetic therapy.
Topics: Azacitidine; Cytidine; DNA Methylation; Epigenesis, Genetic; Genetic Therapy; Humans; Neoplasms; Pyrimidine Nucleosides | 2004 |
Zebularine: a unique molecule for an epigenetically based strategy in cancer chemotherapy. The magic of its chemistry and biology.
Topics: Administration, Oral; Animals; Antineoplastic Agents; Cytidine; Cytidine Deaminase; DNA; Epigenesis, Genetic; Humans; Models, Chemical; Neoplasms | 2005 |
Zebularine: a unique molecule for an epigenetically based strategy in cancer chemotherapy.
Topics: Administration, Oral; Animals; Antineoplastic Agents; Cytidine; Cytidine Deaminase; DNA (Cytosine-5-)-Methyltransferases; DNA Methylation; Epigenesis, Genetic; Humans; Kinetics; Models, Chemical; Neoplasms | 2005 |
[Recent advances in DNA demethylation in tumor therapy].
Topics: Animals; Cytidine; DNA Methylation; DNA Modification Methylases; Gene Knockout Techniques; Histone Acetyltransferases; Histone Deacetylase Inhibitors; Humans; Hydroxamic Acids; Neoplasms; RNA Interference; Valproic Acid | 2009 |
Clinical and biological effects of demethylating agents on solid tumours - A systematic review.
Topics: Antimetabolites, Antineoplastic; Azacitidine; Cytidine; Decitabine; DNA Methylation; Humans; Hydralazine; Immune System; Methylation; Neoplasms; Procaine; Treatment Outcome | 2017 |
190 other study(ies) available for cytidine and pyrimidin-2-one beta-ribofuranoside
| Article | Year |
|---|---|
The mechanism of action of beta-D-2'-deoxy-2'-fluoro-2'-C-methylcytidine involves a second metabolic pathway leading to beta-D-2'-deoxy-2'-fluoro-2'-C-methyluridine 5'-triphosphate, a potent inhibitor of the hepatitis C virus RNA-dependent RNA polymerase.
Topics: Antiviral Agents; Cell Line; Cytidine; Deoxycytidine; Hepacivirus; Humans; Microbial Sensitivity Tests; Phosphorylation; Replicon; RNA-Dependent RNA Polymerase; Structure-Activity Relationship; Uridine Triphosphate | 2008 |
Potent inhibitors for the deamination of cytosine arabinoside and 5-aza-2'-deoxycytidine by human cytidine deaminase.
Topics: Antineoplastic Agents; Azacitidine; Azepines; Cytarabine; Cytidine; Cytidine Deaminase; Deamination; Decitabine; Humans; Kinetics; Pyrimidine Nucleosides; Tetrahydrouridine | 1992 |
Antitumor properties of 2(1H)-pyrimidinone riboside (zebularine) and its fluorinated analogues.
Topics: Administration, Oral; Animals; Antineoplastic Agents; Arabinonucleosides; Cytidine; Drug Screening Assays, Antitumor; Injections, Intraperitoneal; Injections, Subcutaneous; Leukemia L1210; Leukemia P388; Mice; Pyrimidine Nucleosides; Pyrimidinones; Structure-Activity Relationship | 1991 |
Binding of pyrimidin-2-one ribonucleoside by cytidine deaminase as the transition-state analogue 3,4-dihydrouridine and the contribution of the 4-hydroxyl group to its binding affinity.
Topics: Cytidine; Cytidine Deaminase; Electrophoresis, Polyacrylamide Gel; Escherichia coli; Molecular Structure; Nucleoside Deaminases; Pyrimidine Nucleosides; Pyrimidinones; Ribonucleosides; Spectrophotometry, Ultraviolet; Thermodynamics; Uridine | 1989 |
The mechanism of inhibition of DNA synthesis in Escherichia coli by pyrimidin-2-one beta-D-ribofuranoside.
Topics: Animals; Biological Transport; Carbon Radioisotopes; Cattle; Chromatography, Paper; Cytidine; Deoxyribonucleosides; Deoxyribonucleotides; DNA, Bacterial; Electrophoresis, Paper; Escherichia coli; Kinetics; Methyltransferases; Mutation; Pentosyltransferases; Pyrimidine Nucleosides; Pyrimidinones; Ribonucleosides; Thymidylate Synthase; Thymus Gland; Time Factors | 1973 |
Improved synthesis of zebularine [1-(beta-D-ribofuranosyl)-dihydropyrimidin-2-one] nucleotides as inhibitors of human deoxycytidylate deaminase.
Topics: Cell Line; Chromatography, High Pressure Liquid; Cytidine; DCMP Deaminase; Deoxyribonucleotides; Drug Stability; Enzyme Inhibitors; Humans; Hydrogen-Ion Concentration; Kinetics; Lymphocytes; Magnetic Resonance Spectroscopy; Pyrimidine Nucleosides; Pyrimidine Nucleotides; Structure-Activity Relationship | 1995 |
Carbocyclic analogues of the potent cytidine deaminase inhibitor 1-(beta-D-ribofuranosyl)-1,2-dihydropyrimidin-2-one (zebularine).
Topics: Animals; Cytidine; Cytidine Deaminase; Enzyme Inhibitors; Humans; Mice; Pyrimidine Nucleosides; Structure-Activity Relationship | 1998 |
Substrate connectivity effects in the transition state for cytidine deaminase.
Topics: Binding Sites; Cytidine; Cytidine Deaminase; Drug Synergism; Enzyme Inhibitors; Escherichia coli; Hydroxides; Kinetics; Ligands; Models, Chemical; Pyrimidine Nucleosides; Substrate Specificity | 1998 |
Zebularine: a novel DNA methylation inhibitor that forms a covalent complex with DNA methyltransferases.
Topics: Antineoplastic Agents; Base Sequence; Crystallography, X-Ray; Cytidine; DNA; DNA Methylation; DNA-Cytosine Methylases; Haemophilus; Hydrogen Bonding; Models, Molecular; Molecular Structure; Nucleic Acid Conformation; Protein Conformation; Pyrimidine Nucleosides | 2002 |
Inhibition of DNA methylation and reactivation of silenced genes by zebularine.
Topics: Administration, Oral; Animals; Blotting, Southern; Cinnamates; Cytidine; DNA Methylation; DNA, Neoplasm; Dose-Response Relationship, Drug; Drug Administration Schedule; Embryo, Mammalian; Gene Expression Regulation, Fungal; Gene Expression Regulation, Neoplastic; Gene Silencing; Humans; Hygromycin B; Infusions, Parenteral; Mice; Mice, Inbred BALB C; Mice, Nude; Neurospora crassa; Phosphotransferases (Alcohol Group Acceptor); Pyrimidine Nucleosides; Reverse Transcriptase Polymerase Chain Reaction; Time Factors; Tumor Cells, Cultured; Urinary Bladder Neoplasms | 2003 |
Human cytomegalovirus requires cellular deoxycytidylate deaminase for replication in quiescent cells.
Topics: Cells, Cultured; Cytidine; Cytidine Deaminase; Cytomegalovirus; DNA, Viral; Enzyme Inhibitors; Humans; Interphase; Nucleoside Deaminases; Pyrimidine Nucleosides; Pyrophosphatases; Virus Replication | 2003 |
Drug reactivates genes to inhibit cancer.
Topics: Animals; Cytidine; DNA Methylation; Genes, Tumor Suppressor; Pyrimidine Nucleosides; Technology, Pharmaceutical | 2003 |
Synthesis, stability, and protonation studies of a self-complementary dodecamer containing the modified nucleoside 2'-deoxyzebularine.
Topics: Chromatography, High Pressure Liquid; Cytidine; DNA; Hydrogen-Ion Concentration; Kinetics; Mass Spectrometry; Models, Theoretical; Nucleic Acid Conformation; Oligodeoxyribonucleotides; Protons; Pyrimidine Nucleosides; Spectrometry, Fluorescence; Temperature; Time Factors | 2004 |
Mutagenicity of the cytidine analog zebularine in Escherichia coli.
Topics: Base Pair Mismatch; Base Pairing; Cytidine; DNA Repair; DNA-Directed RNA Polymerases; DNA, Bacterial; Escherichia coli; Frameshift Mutation; Mutagenesis; Mutagens; Pyrimidine Nucleosides | 2004 |
Continuous zebularine treatment effectively sustains demethylation in human bladder cancer cells.
Topics: Azacitidine; Cytidine; Decitabine; DNA; DNA (Cytosine-5-)-Methyltransferase 1; DNA (Cytosine-5-)-Methyltransferases; DNA Methylation; Enzyme Inhibitors; Gene Silencing; Genes, p16; Humans; Pyrimidine Nucleosides; Urinary Bladder Neoplasms | 2004 |
Potent inhibition of HhaI DNA methylase by the aglycon of 2-(1H)-pyrimidinone riboside (zebularine) at the GCGC recognition domain.
Topics: Antineoplastic Agents; Cytidine; Cytidine Deaminase; DNA; DNA (Cytosine-5-)-Methyltransferases; DNA-Cytosine Methylases; Protein Structure, Tertiary; Pyrimidine Nucleosides; Structure-Activity Relationship | 2003 |
Microarray analysis of epigenetic silencing of gene expression in the KAS-6/1 multiple myeloma cell line.
Topics: Cell Line, Tumor; Cytidine; DNA Methylation; Gene Expression Regulation, Neoplastic; Gene Silencing; Genome, Human; Humans; Multiple Myeloma; Oligonucleotide Array Sequence Analysis; Pyrimidine Nucleosides; Reverse Transcriptase Polymerase Chain Reaction; Ribonucleases | 2004 |
Scientists probe shutting down cancer cells by awakening silenced genes.
Topics: Animals; Antineoplastic Agents; Cytidine; DNA Methylation; Gene Expression Regulation, Neoplastic; Gene Silencing; Genes, Tumor Suppressor; Humans; Neoplasms; Pyrimidine Nucleosides | 2004 |
Preferential response of cancer cells to zebularine.
Topics: Antineoplastic Agents; Cell Division; Cell Line, Tumor; Cytidine; DNA (Cytosine-5-)-Methyltransferases; DNA Methylation; DNA, Neoplasm; Fibroblasts; Gene Expression Regulation, Neoplastic; Gene Silencing; Genes, p16; Humans; Neoplasms; Pyrimidine Nucleosides | 2004 |
Zebularine: a candidate for epigenetic cancer therapy.
Topics: Antineoplastic Agents; Cytidine; Epigenesis, Genetic; Humans; Neoplasms; Pyrimidine Nucleosides | 2004 |
The in vitro and in vivo effects of re-expressing methylated von Hippel-Lindau tumor suppressor gene in clear cell renal carcinoma with 5-aza-2'-deoxycytidine.
Topics: Adenocarcinoma, Clear Cell; Animals; Antimetabolites, Antineoplastic; Azacitidine; Cytidine; Decitabine; Disease Models, Animal; DNA Methylation; Gene Silencing; Humans; Kidney Neoplasms; Mice; Pyrimidine Nucleosides; Reverse Transcriptase Polymerase Chain Reaction; Transfection; Transplantation, Heterologous; Tumor Cells, Cultured; Tumor Suppressor Proteins; Ubiquitin-Protein Ligases; Von Hippel-Lindau Tumor Suppressor Protein | 2004 |
Three-dimensional structure of the R115E mutant of T4-bacteriophage 2'-deoxycytidylate deaminase.
Topics: Allosteric Regulation; Amino Acid Substitution; Arginine; Bacteriophage T4; Binding Sites; Crystallization; Crystallography, X-Ray; Cytidine; Cytidine Deaminase; DCMP Deaminase; Glutamic Acid; Models, Molecular; Mutagenesis, Site-Directed; Nucleoside Deaminases; Protein Structure, Quaternary; Protein Subunits; Pyrimidine Nucleosides; Substrate Specificity; Viral Proteins; Zinc | 2004 |
Epigenetic silencing of the human nucleotide excision repair gene, hHR23B, in interleukin-6-responsive multiple myeloma KAS-6/1 cells.
Topics: Base Sequence; Cell Line, Tumor; CpG Islands; Culture Media; Cytidine; Cytosine; DNA; DNA Damage; DNA Methylation; DNA Repair; DNA Repair Enzymes; DNA-Binding Proteins; DNA, Complementary; Dose-Response Relationship, Radiation; Down-Regulation; Gene Expression Regulation; Gene Expression Regulation, Neoplastic; Gene Silencing; Genes, Reporter; Humans; Interleukin-6; Karyotyping; Kinetics; Molecular Sequence Data; Multiple Myeloma; Plasmids; Promoter Regions, Genetic; Pyrimidine Nucleosides; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sulfites; Transcription, Genetic; Ultraviolet Rays | 2005 |
Enhancement of antineoplastic action of 5-aza-2'-deoxycytidine by zebularine on L1210 leukemia.
Topics: Animals; Antimetabolites, Antineoplastic; Azacitidine; Cell Line, Tumor; Cytidine; Cytidine Deaminase; Decitabine; DNA Methylation; Dose-Response Relationship, Drug; Drug Interactions; Humans; Leukemia L1210; Male; Mice; Pyrimidine Nucleosides; Reverse Transcriptase Polymerase Chain Reaction; Tumor Stem Cell Assay | 2005 |
Origin of tight binding of a near-perfect transition-state analogue by cytidine deaminase: implications for enzyme catalysis.
Topics: Cytidine; Cytidine Deaminase; Escherichia coli; Escherichia coli Proteins; Models, Molecular; Pyrimidine Nucleosides; Quantum Theory | 2005 |
Metabolic activation of zebularine, a novel DNA methylation inhibitor, in human bladder carcinoma cells.
Topics: Animals; Biotransformation; Cell Division; Cell Line, Tumor; Cytidine; DNA; DNA Methylation; Dose-Response Relationship, Drug; Enzyme Inhibitors; Humans; Male; Mice; Mice, Inbred BALB C; Phosphorylation; RNA; Urinary Bladder Neoplasms | 2005 |
Plasma pharmacokinetics, oral bioavailability, and interspecies scaling of the DNA methyltransferase inhibitor, zebularine.
Topics: Administration, Oral; Animals; Area Under Curve; Biological Availability; Chromatography, High Pressure Liquid; Cytidine; DNA Modification Methylases; Female; Infusions, Intravenous; Macaca mulatta; Male; Mice; Rats | 2005 |
Interleukin 6 supports the maintenance of p53 tumor suppressor gene promoter methylation.
Topics: Apoptosis; Azacitidine; Base Sequence; Cell Cycle; Cell Line, Tumor; Cytidine; Decitabine; Deoxycytidine; DNA (Cytosine-5-)-Methyltransferase 1; DNA (Cytosine-5-)-Methyltransferases; DNA Methylation; Gene Silencing; Genes, p53; Humans; Interleukin-6; Molecular Sequence Data; Multiple Myeloma; Promoter Regions, Genetic; Sulfites; Tumor Suppressor Protein p53 | 2005 |
Enhancement of in vitro and in vivo tumor cell radiosensitivity by the DNA methylation inhibitor zebularine.
Topics: 14-3-3 Proteins; Animals; Apoptosis; Biomarkers, Tumor; Cell Line, Tumor; Cell Survival; Combined Modality Therapy; Cytidine; DNA Methylation; DNA-Binding Proteins; Dose-Response Relationship, Radiation; Exonucleases; Exoribonucleases; Gene Expression Regulation, Neoplastic; Humans; Kruppel-Like Transcription Factors; Male; Mice; Mice, Nude; Neoplasm Proteins; Neoplasms, Experimental; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Time Factors; Transcription Factors; Tumor Suppressor Proteins; Xenograft Model Antitumor Assays | 2005 |
Zebularine metabolism by aldehyde oxidase in hepatic cytosol from humans, monkeys, dogs, rats, and mice: influence of sex and inhibitors.
Topics: Aldehyde Oxidase; Animals; Chromatography, High Pressure Liquid; Cytidine; Cytosol; Dogs; Enzyme Inhibitors; Female; Haplorhini; Humans; Liver; Macaca fascicularis; Male; Mice; Rats | 2006 |
Antimitogenic and chemosensitizing effects of the methylation inhibitor zebularine in ovarian cancer.
Topics: Antineoplastic Combined Chemotherapy Protocols; Azacitidine; Cell Growth Processes; Cell Line, Tumor; Cisplatin; Cytidine; Decitabine; DNA Methylation; Drug Synergism; Female; Gene Expression Regulation, Neoplastic; Gene Silencing; Genes, Tumor Suppressor; Humans; Ovarian Neoplasms | 2005 |
Comparison of biological effects of non-nucleoside DNA methylation inhibitors versus 5-aza-2'-deoxycytidine.
Topics: Antimetabolites, Antineoplastic; Azacitidine; Carcinoma, Transitional Cell; Catechin; Cell Line, Tumor; Colorectal Neoplasms; Cytidine; Decitabine; Deoxycytidine; DNA Methylation; DNA Modification Methylases; Enzyme Inhibitors; Female; Gene Silencing; HT29 Cells; Humans; Hydralazine; Male; Procainamide; Prostatic Neoplasms; Reverse Transcriptase Polymerase Chain Reaction | 2005 |
The novel DNA methylation inhibitor zebularine is effective against the development of murine T-cell lymphoma.
Topics: Animals; Antineoplastic Agents; Cell Transformation, Neoplastic; Cytidine; DNA Methylation; Drug Evaluation, Preclinical; Gene Silencing; Injections, Intraperitoneal; Lymphoma, T-Cell; Mice; Neoplasms, Experimental | 2006 |
Quantitative determination of zebularine (NSC 309132), a DNA methyltransferase inhibitor, and three metabolites in murine plasma by high-performance liquid chromatography coupled with on-line radioactivity detection.
Topics: Animals; Carbon Radioisotopes; Chromatography, High Pressure Liquid; Cytidine; DNA Modification Methylases; Drug Stability; Male; Mice; Mice, Inbred Strains; Online Systems; Reproducibility of Results; Sensitivity and Specificity; Specific Pathogen-Free Organisms; Spectrophotometry, Ultraviolet; Uracil; Uridine | 2006 |
Cytosine-thymine addition product from DNA irradiated with ultraviolet light.
Topics: Cytidine; Cytosine; DNA; Magnetic Resonance Spectroscopy; Mass Spectrometry; Photochemistry; Thymine; Ultraviolet Rays | 1967 |
Angiostatic activity of DNA methyltransferase inhibitors.
Topics: Acetylation; Angiogenesis Inhibitors; Animals; Azacitidine; Cell Movement; Cytidine; DNA Modification Methylases; Endothelial Cells; Enzyme Inhibitors; Gene Expression; Histones; Humans; Hydroxamic Acids; Insulin-Like Growth Factor Binding Protein 3; Melanoma, Experimental; Mice; Mice, Mutant Strains; Neovascularization, Pathologic; Neovascularization, Physiologic; Thrombospondin 1 | 2006 |
Functional diversity of DNA methyltransferase inhibitors in human cancer cell lines.
Topics: Azacitidine; Catechin; Cell Line, Tumor; Cytidine; Decitabine; DNA (Cytosine-5-)-Methyltransferases; DNA Methylation; Enzyme Inhibitors; Humans; Indoles; Jurkat Cells; Phthalimides; Procaine; Propionates; Tryptophan | 2006 |
p53 expression after treatment with zebularine is not due to demethylation.
Topics: Cell Line, Tumor; Cytidine; DNA Methylation; Humans; Multiple Myeloma; Sequence Analysis, DNA; Tumor Suppressor Protein p53 | 2006 |
Reversal of p53 epigenetic silencing in multiple myeloma permits apoptosis by a p53 activator.
Topics: Amino Acid Sequence; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Cell Line, Tumor; Cytidine; DNA Methylation; Drug Synergism; Epigenesis, Genetic; Gene Silencing; Genes, p53; Humans; Molecular Sequence Data; Multiple Myeloma; Peptides; Promoter Regions, Genetic; Tumor Suppressor Protein p53 | 2006 |
Reactivation of p53 function with a demethylating agent.
Topics: Cell Line, Tumor; Cytidine; DNA Methylation; Gene Expression Regulation; Genes, p53; Humans; Tumor Suppressor Protein p53 | 2006 |
A mass balance and disposition study of the DNA methyltransferase inhibitor zebularine (NSC 309132) and three of its metabolites in mice.
Topics: Animals; Chromatography, High Pressure Liquid; Cytidine; DNA Modification Methylases; Male; Mice; Uracil; Uridine | 2006 |
DNA methyltransferase inhibitors coordinately induce expression of the human reelin and glutamic acid decarboxylase 67 genes.
Topics: Acetylation; Azacitidine; Cell Adhesion Molecules, Neuronal; Cells, Cultured; Cytidine; Decitabine; DNA (Cytosine-5-)-Methyltransferase 1; DNA (Cytosine-5-)-Methyltransferases; Dose-Response Relationship, Drug; Doxorubicin; Enzyme Inhibitors; Extracellular Matrix Proteins; Gene Expression Regulation; Glutamate Decarboxylase; Histones; Humans; Isoenzymes; Methyl-CpG-Binding Protein 2; Nerve Tissue Proteins; Reelin Protein; RNA, Messenger; Serine Endopeptidases | 2007 |
Epigenetic regulation of tumor endothelial cell anergy: silencing of intercellular adhesion molecule-1 by histone modifications.
Topics: Acetylation; Animals; Cell Adhesion; Clonal Anergy; Cytidine; DNA Modification Methylases; Down-Regulation; Endothelial Cells; Epigenesis, Genetic; Gene Silencing; Histone Deacetylase Inhibitors; Histone Deacetylases; Histones; Humans; Intercellular Adhesion Molecule-1; Leukocytes; Melanoma, Experimental; Methylation; Mice; Mice, Inbred C57BL | 2006 |
Methylation of tumour suppressor genes APAF-1 and DAPK-1 and in vitro effects of demethylating agents in bladder and kidney cancer.
Topics: Aged; Antimetabolites, Antineoplastic; Apoptosis Regulatory Proteins; Apoptotic Protease-Activating Factor 1; Azacitidine; Calcium-Calmodulin-Dependent Protein Kinases; Carcinoma, Renal Cell; Carcinoma, Transitional Cell; Cells, Cultured; Cytidine; Death-Associated Protein Kinases; DNA Methylation; Female; Gene Expression Regulation, Neoplastic; Humans; In Vitro Techniques; Kidney; Kidney Neoplasms; Male; Promoter Regions, Genetic; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Urinary Bladder; Urinary Bladder Neoplasms | 2006 |
Apoptosis, proliferation and differentiation patterns are influenced by Zebularine and SAHA in pancreatic cancer models.
Topics: Animals; Antineoplastic Agents; Apoptosis; bcl-2-Associated X Protein; Cell Differentiation; Cell Proliferation; Cytidine; DNA, Neoplasm; Epigenesis, Genetic; Histone Deacetylase Inhibitors; Humans; Hydroxamic Acids; Immunohistochemistry; Male; Mice; Mice, Nude; Neoplasm Proteins; Pancreatic Neoplasms; Tumor Cells, Cultured; Vorinostat | 2007 |
Zebularine reactivates silenced E-cadherin but unlike 5-Azacytidine does not induce switching from latent to lytic Epstein-Barr virus infection in Burkitt's lymphoma Akata cells.
Topics: Antineoplastic Agents; Azacitidine; Burkitt Lymphoma; Cadherins; Cytidine; Gene Silencing; Herpesvirus 4, Human; Humans; Tumor Cells, Cultured; Virus Latency | 2007 |
Zebularine inhibits human acute myeloid leukemia cell growth in vitro in association with p15INK4B demethylation and reexpression.
Topics: Acetylation; Acute Disease; Apoptosis; Cell Division; Cell Line, Tumor; Cell Proliferation; Cyclin-Dependent Kinase Inhibitor p15; Cytidine; DNA Methylation; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; G2 Phase; Gene Expression Profiling; Histones; HL-60 Cells; Humans; Hydroxamic Acids; Leukemia, Myeloid; Phosphorylation; Promoter Regions, Genetic; Reverse Transcriptase Polymerase Chain Reaction | 2007 |
Low dose Zebularine treatment enhances immunogenicity of tumor cells.
Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Cytidine; Cytokines; DNA Methylation; Dose-Response Relationship, Drug; Immunosuppressive Agents; Male; Neoplasms; Rats; Reverse Transcriptase Polymerase Chain Reaction; Spleen; Transfection | 2007 |
Epigenetic regulation of chemosensitivity to 5-fluorouracil and cisplatin by zebularine in oral squamous cell carcinoma.
Topics: Antineoplastic Agents; Apoptosis; Carcinoma, Squamous Cell; Cell Cycle; Cell Line, Tumor; Cisplatin; Cytidine; DNA Methylation; Epigenesis, Genetic; Fluorouracil; Humans; Hydroxamic Acids; Mouth Neoplasms; Vorinostat | 2007 |
Inhibition of DNA methylation is involved in transdifferentiation of myoblasts into smooth muscle cells.
Topics: Animals; Cell Transdifferentiation; Cells, Cultured; Cyclin D1; Cytidine; DNA Methylation; Enzyme Induction; Epigenesis, Genetic; Mice; Muscle, Smooth; Myoblasts; p21-Activated Kinases | 2007 |
Incorporation of zebularine from its 2'-deoxyribonucleoside triphosphate derivative and activity as a template-coding nucleobase.
Topics: Base Pairing; Cytidine; DNA-Cytosine Methylases; Enzyme Inhibitors; Models, Molecular; Oligonucleotides; Sequence Analysis, DNA | 2008 |
Inhibition of cytidine deaminase by zebularine enhances the antineoplastic action of 5-aza-2'-deoxycytidine.
Topics: 3T3 Cells; Animals; Antineoplastic Agents; Azacitidine; Cytidine; Cytidine Deaminase; Decitabine; Drug Synergism; Enzyme Inhibitors; Leukemia, Experimental; Male; Mice; Mice, Inbred BALB C; Mice, Inbred DBA | 2009 |
Epigenetic regulation of human buccal mucosa mitochondrial superoxide dismutase gene expression by diet.
Topics: Adult; Aged, 80 and over; Aging; Caco-2 Cells; Cheek; CpG Islands; Cytidine; Diet; Diet, Vegetarian; DNA Methylation; Enzyme Inhibitors; Epigenesis, Genetic; Female; Gene Expression Regulation, Enzymologic; Humans; Male; Methyltransferases; Mitochondria; Mouth Mucosa; Superoxide Dismutase; Telomerase; Young Adult | 2009 |
Effective, homogeneous and transient interference with cytosine methylation in plant genomic DNA by zebularine.
Topics: Arabidopsis; Cytidine; Cytosine; Deoxycytidine; DNA Methylation; DNA, Plant; Dose-Response Relationship, Drug; Genome, Plant; Medicago sativa | 2009 |
Zebularine suppresses the apoptotic potential of 5-fluorouracil via cAMP/PKA/CREB pathway against human oral squamous cell carcinoma cells.
Topics: Adjuvants, Immunologic; Antimetabolites, Antineoplastic; Antineoplastic Agents; Apoptosis; Benzoquinones; Blotting, Western; Carcinoma, Squamous Cell; Cell Line, Tumor; Cisplatin; Cyclic AMP Response Element-Binding Protein; Cyclic AMP-Dependent Protein Kinases; Cytidine; DNA (Cytosine-5-)-Methyltransferases; Fluorouracil; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; HSP90 Heat-Shock Proteins; Humans; In Situ Nick-End Labeling; Lactams, Macrocyclic; Lithium Chloride; Mouth Neoplasms; NF-kappa B; Phosphorylation; Proto-Oncogene Proteins c-bcl-2; Signal Transduction | 2009 |
Activation of p16 gene silenced by DNA methylation in cancer cells by phosphoramidate derivatives of 2'-deoxyzebularine.
Topics: Adenocarcinoma; Amides; Cytidine; DCMP Deaminase; DNA Methylation; Dose-Response Relationship, Drug; Gene Silencing; Genes, p16; Humans; Molecular Structure; Pancreatic Neoplasms; Phosphoric Acids; Reverse Transcriptase Polymerase Chain Reaction; Stereoisomerism; Thymidylate Synthase; Tumor Cells, Cultured | 2008 |
Cancer prevention: epigenetics steps up to the plate.
Topics: Antimetabolites, Antineoplastic; Azacitidine; Cell Transformation, Neoplastic; Chemoprevention; Cytidine; Decitabine; DNA (Cytosine-5-)-Methyltransferases; DNA Methylation; Enzyme Inhibitors; Epigenesis, Genetic; Humans; Models, Biological; Neoplasms | 2008 |
Long-term epigenetic therapy with oral zebularine has minimal side effects and prevents intestinal tumors in mice.
Topics: Administration, Oral; Animals; Antimetabolites, Antineoplastic; Carcinoma; Cytidine; DNA Methylation; Epigenesis, Genetic; Female; Gene Expression Profiling; Genes, APC; Intestinal Mucosa; Intestinal Neoplasms; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Oligonucleotide Array Sequence Analysis; Organ Specificity; Sex Characteristics; Time Factors | 2008 |
Lasting epigenetic influence of early-life adversity on the BDNF gene.
Topics: Animals; Animals, Newborn; Brain-Derived Neurotrophic Factor; Cytidine; DNA Methylation; Epigenesis, Genetic; Female; Gene Expression; Hippocampus; Injections, Intraventricular; Male; Maternal Behavior; Models, Animal; Prefrontal Cortex; Rats; Rats, Long-Evans; Stress, Psychological | 2009 |
The DNA methyltransferase inhibitors azacitidine, decitabine and zebularine exert differential effects on cancer gene expression in acute myeloid leukemia cells.
Topics: Antimetabolites, Antineoplastic; Apoptosis; Azacitidine; Cell Differentiation; Cell Line, Tumor; Cell Proliferation; Cytidine; Decitabine; DNA Methylation; DNA Modification Methylases; Enzyme Inhibitors; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Humans; Leukemia, Myeloid, Acute | 2009 |
Effects of a novel DNA methyltransferase inhibitor zebularine on human breast cancer cells.
Topics: Adenocarcinoma; Apoptosis Regulatory Proteins; Azacitidine; Breast Neoplasms; Cell Cycle Proteins; Cell Line, Tumor; Chromatin Immunoprecipitation; Cytidine; Cytidine Deaminase; Decitabine; DNA (Cytosine-5-)-Methyltransferases; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Drug Synergism; Enzyme Inhibitors; Female; Gene Expression Regulation, Neoplastic; Humans; Hydroxamic Acids; Neoplasm Proteins; Receptors, Estrogen; S Phase; Tumor Stem Cell Assay; Vorinostat | 2010 |
DNA (Cytosine-C5) methyltransferase inhibition by oligodeoxyribonucleotides containing 2-(1H)-pyrimidinone (zebularine aglycon) at the enzymatic target site.
Topics: Binding Sites; Cytidine; Cytosine; DNA; DNA (Cytosine-5-)-Methyltransferase 1; DNA (Cytosine-5-)-Methyltransferases; Models, Molecular; Nucleic Acid Conformation; Oligodeoxyribonucleotides; Protein Conformation; Structure-Activity Relationship | 2009 |
Profiling the repertoire of phenotypes influenced by environmental cues that occur during asexual reproduction.
Topics: Adaptation, Physiological; Animals; Aphids; CpG Islands; Cytidine; DNA Methylation; Electrophoresis, Gel, Two-Dimensional; Epigenesis, Genetic; Female; Founder Effect; Genetic Variation; Genome, Insect; Insect Proteins; Male; Methyltransferases; Parthenogenesis; Phenotype; Seasons; Sexual Behavior, Animal | 2009 |
Methylation of zebularine: a quantum mechanical study incorporating interactive 3D pdf graphs.
Topics: Computer Graphics; Cytidine; Methylation; Models, Molecular; Molecular Structure; Quantum Theory | 2009 |
Specific promoter methylation identifies different subgroups of MLL-rearranged infant acute lymphoblastic leukemia, influences clinical outcome, and provides therapeutic options.
Topics: Cell Line, Tumor; Cell Survival; Chromosomes, Human, Pair 11; Chromosomes, Human, Pair 19; Chromosomes, Human, Pair 4; Chromosomes, Human, Pair 9; Cluster Analysis; CpG Islands; Cytidine; DNA Methylation; Dose-Response Relationship, Drug; Gene Expression Profiling; Gene Expression Regulation, Leukemic; Humans; Infant; Jurkat Cells; Myeloid-Lymphoid Leukemia Protein; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Survival Analysis; Translocation, Genetic; Treatment Outcome | 2009 |
The liver X-receptor gene promoter is hypermethylated in a mouse model of prenatal protein restriction.
Topics: Animals; Base Sequence; Birth Weight; Body Weight; Chlorocebus aethiops; COS Cells; CpG Islands; Cytidine; Diet; DNA Methylation; Epigenesis, Genetic; Female; Lipid Metabolism; Liver; Liver X Receptors; Male; Mice; Mice, Inbred C57BL; Molecular Sequence Data; Oligonucleotide Array Sequence Analysis; Orphan Nuclear Receptors; Pregnancy; Prenatal Exposure Delayed Effects; Promoter Regions, Genetic; Protein-Energy Malnutrition | 2010 |
DNA-dependent protein kinase (DNA-PK)-deficient human glioblastoma cells are preferentially sensitized by Zebularine.
Topics: Apoptosis; Blotting, Western; Brain Neoplasms; Cell Cycle; Cell Proliferation; Cytidine; DNA Adducts; DNA Methylation; DNA-Activated Protein Kinase; Drug Resistance, Neoplasm; Glioblastoma; Humans; Promoter Regions, Genetic; Tumor Cells, Cultured | 2010 |
Use of Drosophila deoxynucleoside kinase to study mechanism of toxicity and mutagenicity of deoxycytidine analogs in Escherichia coli.
Topics: Animals; Antineoplastic Agents; Azacitidine; Cytidine; Deoxycytidine; DNA; DNA Methylation; DNA Mismatch Repair; Drosophila melanogaster; Escherichia coli; Fluorescence; Microbial Sensitivity Tests; Mutagenesis; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor) | 2010 |
Chemotherapeutic drug-induced ABCG2 promoter demethylation as a novel mechanism of acquired multidrug resistance.
Topics: Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Azacitidine; Cell Line, Tumor; Cell Proliferation; Cytidine; Decitabine; DNA Methylation; Drug Resistance, Neoplasm; Gene Expression Regulation, Neoplastic; Humans; Jurkat Cells; K562 Cells; Neoplasm Proteins; Precursor T-Cell Lymphoblastic Leukemia-Lymphoma; Promoter Regions, Genetic; Reverse Transcriptase Polymerase Chain Reaction | 2009 |
MicroRNA let-7 suppresses nasopharyngeal carcinoma cells proliferation through downregulating c-Myc expression.
Topics: Azacitidine; Carcinoma; Cell Growth Processes; Cell Line, Tumor; Cytidine; DNA Methylation; Down-Regulation; Gene Expression Regulation, Neoplastic; Humans; Immunohistochemistry; MicroRNAs; Nasopharyngeal Carcinoma; Nasopharyngeal Neoplasms; Proto-Oncogene Proteins c-myc; Transfection; Up-Regulation | 2011 |
DNA methylation regulates cocaine-induced behavioral sensitization in mice.
Topics: Animals; Cocaine; Cytidine; DNA (Cytosine-5-)-Methyltransferases; DNA Methylation; DNA Methyltransferase 3A; DNA Methyltransferase 3B; Down-Regulation; Drug Interactions; Male; Methyl-CpG-Binding Protein 2; Mice; Mice, Inbred C57BL; Motor Activity; Nucleus Accumbens; Promoter Regions, Genetic; Protein Phosphatase 1; Proto-Oncogene Proteins c-fos; Up-Regulation | 2010 |
Mechanistic insights on the inhibition of c5 DNA methyltransferases by zebularine.
Topics: Animals; Azacitidine; Base Sequence; Cytidine; Decitabine; DNA; DNA (Cytosine-5-)-Methyltransferases; Enzyme Inhibitors; Humans; Methylation; Mice | 2010 |
Enhanced growth inhibition by combined DNA methylation/HDAC inhibitors in lung tumor cells with silenced CDKN2A.
Topics: Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Proliferation; CpG Islands; Cytidine; Depsipeptides; DNA Methylation; DNA Modification Methylases; Dose-Response Relationship, Drug; Drug Synergism; Enzyme Inhibitors; Gene Deletion; Gene Expression Regulation, Neoplastic; Gene Silencing; Genes, p16; Histone Deacetylase Inhibitors; Humans; Lung Neoplasms; Precision Medicine; Time Factors | 2010 |
Measuring topology of low-intensity DNA methylation sites for high-throughput assessment of epigenetic drug-induced effects in cancer cells.
Topics: Antineoplastic Agents; Azacitidine; Cell Line, Tumor; Cell Nucleus; Cytidine; Cytosine; DNA Methylation; DNA, Neoplasm; Epigenesis, Genetic; Fluorescence; High-Throughput Screening Assays; Humans; Indoles; Neoplasms; Nucleic Acid Conformation | 2010 |
The effect of epigenetic regulation of fucosylation on TRAIL-induced apoptosis.
Topics: Apoptosis; Caspase 8; Cell Line, Tumor; Cytidine; DNA Methylation; Drug Synergism; Enzyme Activation; Enzyme Inhibitors; Epigenesis, Genetic; Fucose; Glycosylation; Humans; Protein Processing, Post-Translational; Receptors, TNF-Related Apoptosis-Inducing Ligand; Signal Transduction; TNF-Related Apoptosis-Inducing Ligand | 2010 |
An integrated genomic and epigenomic approach predicts therapeutic response to zebularine in human liver cancer.
Topics: Animals; Antineoplastic Agents; Carcinoma, Hepatocellular; Cell Line, Tumor; CpG Islands; Cytidine; DNA Methylation; Epigenesis, Genetic; Gene Expression Profiling; Genome, Human; Humans; Liver Neoplasms; Mice; Transplantation, Heterologous | 2010 |
Hypermethylation of specific microRNA genes in MLL-rearranged infant acute lymphoblastic leukemia: major matters at a micro scale.
Topics: Chromosomes, Human, Pair 11; Chromosomes, Human, Pair 4; CpG Islands; Cytidine; DNA (Cytosine-5-)-Methyltransferase 1; DNA (Cytosine-5-)-Methyltransferases; DNA Methylation; Gene Rearrangement; Histone-Lysine N-Methyltransferase; Homeodomain Proteins; Humans; Infant; MicroRNAs; Myeloid-Lymphoid Leukemia Protein; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Repressor Proteins; Translocation, Genetic; Zinc Finger E-box Binding Homeobox 2 | 2011 |
Insights into mutagenesis using Escherichia coli chromosomal lacZ strains that enable detection of a wide spectrum of mutational events.
Topics: Amino Acid Sequence; Base Sequence; Chromosomes, Bacterial; Cytidine; DNA Mutational Analysis; DNA Replication; DNA, Bacterial; Escherichia coli; Escherichia coli Proteins; Frameshift Mutation; Hydroxyurea; Inverted Repeat Sequences; Lac Operon; Molecular Sequence Data; Mutagenesis; Mutation; Nucleic Acid Conformation; Nucleic Acid Synthesis Inhibitors; Sequence Deletion | 2011 |
The DNA methyltransferase inhibitors zebularine and decitabine induce mitochondria-mediated apoptosis and DNA damage in p53 mutant leukemic T cells.
Topics: Apoptosis; Azacitidine; Caspase 9; Cell Cycle; Cell Line, Tumor; Cytidine; Decitabine; DNA (Cytosine-5-)-Methyltransferases; DNA Damage; Genes, p53; Humans; Leukemia, T-Cell; Mitochondria; Mutation; Reactive Oxygen Species; T-Lymphocytes | 2012 |
Methylation of zebularine investigated using density functional theory calculations.
Topics: Cytidine; Methylation; Molecular Dynamics Simulation; Pyrimidinones; Spectrum Analysis, Raman | 2011 |
Human hepatic cancer stem cells are characterized by common stemness traits and diverse oncogenic pathways.
Topics: Animals; Cell Line, Tumor; Cytidine; Epigenesis, Genetic; Gene Expression Profiling; Humans; Liver Neoplasms; Mice; Neoplastic Stem Cells | 2011 |
Epigenetic changes by zebularine leading to enhanced differentiation of human promyelocytic leukemia NB4 and KG1 cells.
Topics: Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Cell Differentiation; Cell Line, Tumor; Cytidine; DNA (Cytosine-5-)-Methyltransferase 1; DNA (Cytosine-5-)-Methyltransferases; Dose-Response Relationship, Drug; Drug Synergism; Epigenesis, Genetic; Humans; Leukemia, Promyelocytic, Acute; Tretinoin | 2012 |
Hypomethylating drugs efficiently decrease cytosine methylation in telomeric DNA and activate telomerase without affecting telomere lengths in tobacco cells.
Topics: Adenine; Cells, Cultured; Cytidine; DNA Methylation; DNA, Plant; Enzyme Activation; Epigenesis, Genetic; Nicotiana; Nucleosomes; Plant Proteins; Telomerase; Telomere; Transcription, Genetic | 2011 |
GSTP1 DNA methylation and expression status is indicative of 5-aza-2'-deoxycytidine efficacy in human prostate cancer cells.
Topics: Azacitidine; Biomarkers, Tumor; Cell Death; Cell Line, Tumor; Cell Proliferation; Cell Survival; Cytidine; Decitabine; DNA Methylation; Dose-Response Relationship, Drug; Drug Discovery; Enzyme Inhibitors; Gene Expression Regulation, Neoplastic; Gene Silencing; Glutathione S-Transferase pi; Humans; Male; Promoter Regions, Genetic; Prostate-Specific Antigen; Prostatic Neoplasms; Time Factors | 2011 |
Zebularine suppresses TGF-beta-induced lens epithelial cell-myofibroblast transdifferentiation by inhibiting MeCP2.
Topics: Actins; Blotting, Western; Capsule Opacification; Cataract Extraction; Cell Transdifferentiation; Cells, Cultured; Cytidine; Dose-Response Relationship, Drug; Epithelial Cells; Gene Expression; Gene Silencing; Humans; Methyl-CpG-Binding Protein 2; Microscopy, Confocal; Myofibroblasts; Posterior Capsule of the Lens; RNA, Small Interfering; Transforming Growth Factor beta | 2011 |
Epigenetic modulation of the HeLa cell membrane N-glycome.
Topics: Antineoplastic Agents; Azacitidine; Butyrates; Carbohydrate Sequence; Cytidine; Decitabine; DNA Methylation; Epigenesis, Genetic; Gene Expression Regulation, Neoplastic; Glycomics; HeLa Cells; Histone Deacetylase Inhibitors; Humans; Hydroxamic Acids; Molecular Sequence Data; Polysaccharides | 2012 |
DNA methyltransferase inhibitor, zebularine, delays tumor growth and induces apoptosis in a genetically engineered mouse model of breast cancer.
Topics: Administration, Oral; Animals; Antigens, Polyomavirus Transforming; Apoptosis; Breast Neoplasms; Cytidine; Disease Models, Animal; DNA (Cytosine-5-)-Methyltransferase 1; DNA (Cytosine-5-)-Methyltransferases; DNA Methylation; DNA Methyltransferase 3B; Female; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Humans; Immunoblotting; Mammary Neoplasms, Experimental; Mammary Tumor Virus, Mouse; Mice; Mice, Transgenic; Necrosis; Oligonucleotide Array Sequence Analysis; Reverse Transcriptase Polymerase Chain Reaction; Tumor Burden | 2012 |
Effects of a novel DNA methyltransferase inhibitor Zebularine on human lens epithelial cells.
Topics: Capsule Opacification; Cell Adhesion; Cell Movement; Cell Proliferation; Cell Transdifferentiation; Cells, Cultured; Cytidine; DNA (Cytosine-5-)-Methyltransferase 1; DNA (Cytosine-5-)-Methyltransferases; DNA Methylation; Enzyme Inhibitors; Epithelial Cells; Gene Expression Regulation; Humans; Lens Capsule, Crystalline; Mitogen-Activated Protein Kinase 3; Phosphorylation; Proto-Oncogene Proteins c-akt; Signal Transduction; Transforming Growth Factor beta | 2012 |
An epigenetic mechanism for high, synergistic expression of indoleamine 2,3-dioxygenase 1 (IDO1) by combined treatment with zebularine and IFN-γ: potential therapeutic use in autoimmune diseases.
Topics: Animals; Autoimmune Diseases; Cells, Cultured; Cytidine; DNA Methylation; Drug Synergism; Epigenesis, Genetic; Gene Expression; Gene Expression Regulation; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Interferon Regulatory Factor-1; Interferon-gamma; Promoter Regions, Genetic; Rats; Real-Time Polymerase Chain Reaction; Reverse Transcriptase Polymerase Chain Reaction; STAT1 Transcription Factor | 2012 |
DNMT (DNA methyltransferase) inhibitors radiosensitize human cancer cells by suppressing DNA repair activity.
Topics: Azacitidine; Caspase 3; Catechin; Cell Line, Tumor; Cytidine; Decitabine; Disulfides; DNA (Cytosine-5-)-Methyltransferase 1; DNA (Cytosine-5-)-Methyltransferases; DNA Breaks, Double-Stranded; DNA Methyltransferase 3A; DNA Methyltransferase 3B; DNA Repair; Enzyme Induction; Gene Expression Regulation, Neoplastic; Glioblastoma; Histones; Humans; Hydralazine; Inhibitory Concentration 50; Lung Neoplasms; Neoplasm Proteins; Radiation-Sensitizing Agents; Tumor Stem Cell Assay; Tyrosine | 2012 |
Epigenomic silencing of the BMP-4 gene in pituitary adenomas: a potential target for epidrug-induced re-expression.
Topics: Animals; Bone Morphogenetic Protein 4; Cell Line; Chromatin Immunoprecipitation; CpG Islands; Cytidine; DNA Methylation; Enzyme-Linked Immunosorbent Assay; Epigenesis, Genetic; Gene Silencing; Histones; Humans; In Vitro Techniques; Mice; Pituitary Neoplasms; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction | 2012 |
Zebularine inhibits the growth of HeLa cervical cancer cells via cell cycle arrest and caspase-dependent apoptosis.
Topics: Antineoplastic Agents; Apoptosis; Caspase Inhibitors; Caspases; Cell Proliferation; Cytidine; DNA Modification Methylases; Drug Screening Assays, Antitumor; Female; Glutathione; HeLa Cells; Humans; Inhibitory Concentration 50; Membrane Potential, Mitochondrial; Oligopeptides; Reactive Oxygen Species; S Phase Cell Cycle Checkpoints; Uterine Cervical Neoplasms | 2012 |
Transgenerational effects of stress exposure on offspring phenotypes in apomictic dandelion.
Topics: Biological Evolution; Biomass; Cytidine; Gene-Environment Interaction; Genotype; Phenotype; Quantitative Trait Loci; Stress, Physiological; Taraxacum | 2012 |
DNA methylation mediates the discriminatory power of associative long-term memory in honeybees.
Topics: Animals; Bees; Cytidine; DNA (Cytosine-5-)-Methyltransferases; DNA Methylation; Epigenesis, Genetic; Learning; Memory, Long-Term; Olfactory Perception; Time Factors | 2012 |
Flight of a cytidine deaminase complex with an imperfect transition state analogue inhibitor: mass spectrometric evidence for the presence of a trapped water molecule.
Topics: Calorimetry; Cytidine; Cytidine Deaminase; Deamination; Dimerization; Enzyme Inhibitors; Fourier Analysis; Hydrolysis; Hydrophobic and Hydrophilic Interactions; Kinetics; Mass Spectrometry; Protein Binding; Pyrimidine Nucleosides; Thermodynamics; Water | 2012 |
Antileukemic activity of combined epigenetic agents, DNMT inhibitors zebularine and RG108 with HDAC inhibitors, against promyelocytic leukemia HL-60 cells.
Topics: Acetylation; Cadherins; CD11b Antigen; Cell Differentiation; Cell Proliferation; CpG Islands; Cytidine; Enzyme Inhibitors; Epigenesis, Genetic; Histone Deacetylase Inhibitors; Histones; HL-60 Cells; Humans; Indoles; Leukemia, Promyelocytic, Acute; Methylation; Phthalimides; Promoter Regions, Genetic; Propionates; Tretinoin; Tryptophan | 2012 |
Down-regulation and CpG island hypermethylation of CRYAA in age-related nuclear cataract.
Topics: Age Factors; Aged; Blotting, Western; Cataract; Cell Line; CpG Islands; Crystallins; Cytidine; DNA Methylation; Dose-Response Relationship, Drug; Down-Regulation; Epithelial Cells; Gene Expression; Humans; Lens, Crystalline; Middle Aged; Promoter Regions, Genetic; Reverse Transcriptase Polymerase Chain Reaction | 2012 |
DNA methylation inhibitors, 5-azacytidine and zebularine potentiate the transdifferentiation of rat bone marrow mesenchymal stem cells into cardiomyocytes.
Topics: Animals; Azacitidine; Bone Marrow Cells; Cell Fusion; Cell Transdifferentiation; Cells, Cultured; Coculture Techniques; Cytidine; DNA Methylation; DNA Modification Methylases; Dose-Response Relationship, Drug; Enzyme Inhibitors; Female; GATA4 Transcription Factor; Gene Expression Regulation; Homeobox Protein Nkx-2.5; Homeodomain Proteins; Male; Mesenchymal Stem Cells; Myocytes, Cardiac; Rats; Rats, Sprague-Dawley; RNA, Messenger; Transcription Factors; Troponin T | 2013 |
Combinatorial treatment of DNA and chromatin-modifying drugs cause cell death in human and canine osteosarcoma cell lines.
Topics: Amino Acid Chloromethyl Ketones; Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Cell Line, Tumor; Chromatin; Cytidine; DNA; DNA Methylation; Dogs; Drug Screening Assays, Antitumor; Epigenesis, Genetic; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Histone Deacetylase Inhibitors; Humans; Hydroxamic Acids; Osteosarcoma; Vorinostat | 2012 |
The DNA methyltransferase inhibitor zebularine induces mitochondria-mediated apoptosis in gastric cancer cells in vitro and in vivo.
Topics: Animals; Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cell Proliferation; Cyclin-Dependent Kinase Inhibitor p16; Cytidine; DNA (Cytosine-5-)-Methyltransferases; Enzyme Inhibitors; Humans; Mice; Mice, Nude; Mitochondria; Neoplasm Transplantation; Stomach Neoplasms | 2013 |
Reactivation of the silenced thyroid hormone receptor β gene expression delays thyroid tumor progression.
Topics: Animals; Blotting, Western; Cell Line; Cell Movement; Cell Proliferation; Cytidine; DNA Methylation; Humans; Immunohistochemistry; Male; Mice; Mice, Nude; Reverse Transcriptase Polymerase Chain Reaction; Thyroid Hormone Receptors beta; Thyroid Neoplasms; Xenograft Model Antitumor Assays | 2013 |
Folic acid acts through DNA methyltransferases to induce the differentiation of neural stem cells into neurons.
Topics: Animals; Cell Differentiation; Cytidine; DNA (Cytosine-5-)-Methyltransferases; Folic Acid; Intracellular Space; Neural Stem Cells; Neurons; Rats; S-Adenosylhomocysteine; S-Adenosylmethionine | 2013 |
DNA methyltransferase inhibitor zebularine inhibits human hepatic carcinoma cells proliferation and induces apoptosis.
Topics: Antineoplastic Agents; Apoptosis; Carcinoma, Hepatocellular; Caspases; Cell Proliferation; Cytidine; DNA (Cytosine-5-)-Methyltransferases; DNA Methylation; Hep G2 Cells; Humans; Liver Neoplasms; MAP Kinase Signaling System; Phosphorylation | 2013 |
Reversibility of membrane N-glycome of HeLa cells upon treatment with epigenetic inhibitors.
Topics: Butyrates; Cell Membrane; Cytidine; Epigenesis, Genetic; HeLa Cells; Histone Deacetylase Inhibitors; Humans; Hydroxamic Acids; Polysaccharides | 2013 |
Zebularine-induced apoptosis in Calu-6 lung cancer cells is influenced by ROS and GSH level changes.
Topics: Apoptosis; Blotting, Western; Caspases; Cell Cycle; Cell Proliferation; Cytidine; Glutathione; Humans; Lung Neoplasms; Membrane Potential, Mitochondrial; Reactive Oxygen Species; Tumor Cells, Cultured | 2013 |
3-D DNA methylation phenotypes correlate with cytotoxicity levels in prostate and liver cancer cell models.
Topics: 5-Methylcytosine; Antibodies, Monoclonal; Antineoplastic Agents; Apoptosis; Azacitidine; Cell Line, Tumor; Cell Survival; Cytidine; DNA Methylation; Humans; Liver Neoplasms; Male; Phenotype; Prostatic Neoplasms | 2013 |
Preincubation of pituitary tumor cells with the epidrugs zebularine and trichostatin A are permissive for retinoic acid-augmented expression of the BMP-4 and D2R genes.
Topics: Adenoma; Animals; Bone Morphogenetic Protein 4; Cell Culture Techniques; Cytidine; Drug Synergism; Epigenesis, Genetic; Gene Expression Regulation, Neoplastic; Histone Deacetylase Inhibitors; Humans; Hydroxamic Acids; Mice; Pituitary Neoplasms; Prodrugs; Receptors, Dopamine D2; Time Factors; Tretinoin; Tumor Cells, Cultured | 2013 |
Zebularine regulates early stages of mESC differentiation: effect on cardiac commitment.
Topics: Animals; Biomarkers; Cell Differentiation; Cell Line; Cytidine; DNA Methylation; Embryoid Bodies; Gene Expression Profiling; Gene Expression Regulation, Developmental; Humans; Metabolic Networks and Pathways; Mice; Myocytes, Cardiac; Real-Time Polymerase Chain Reaction | 2013 |
Epigenetic switching by the metabolism-sensing factors in the generation of orexin neurons from mouse embryonic stem cells.
Topics: Acetylation; Animals; Cell Differentiation; Cytidine; Deoxycytidine; DNA Methylation; DNA-Cytosine Methylases; Embryonic Stem Cells; Epigenesis, Genetic; Female; Glycosylation; Hexosamines; Histone Deacetylase Inhibitors; Histones; Hydroxamic Acids; Intracellular Signaling Peptides and Proteins; Mice; Mice, Inbred C57BL; Neurons; Neuropeptides; Orexins; Protein Processing, Post-Translational; Sequence Analysis, DNA; Sirtuin 1; Spheroids, Cellular; Transcription Initiation Site | 2013 |
Zebularine inhibits the growth of A549 lung cancer cells via cell cycle arrest and apoptosis.
Topics: Acetylcysteine; Antioxidants; Apoptosis; Caspase 3; Caspase 8; Cell Line, Tumor; Cell Proliferation; Cytidine; DNA Modification Methylases; Down-Regulation; Fibroblasts; G1 Phase Cell Cycle Checkpoints; Glutathione; Humans; Lung Neoplasms; Membrane Potential, Mitochondrial; Proto-Oncogene Proteins c-bcl-2; Reactive Oxygen Species; RNA Interference; RNA, Small Interfering; S Phase Cell Cycle Checkpoints; Thioredoxin Reductase 1; Tumor Suppressor Protein p53 | 2014 |
Zebularine partially reverses GST methylation in prostate cancer cells and restores sensitivity to the DNA minor groove binder brostallicin.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Cell Line, Tumor; Cytidine; DNA Methylation; Gene Expression Regulation, Neoplastic; Glutathione Transferase; Guanidines; Humans; Male; Mice; Prostatic Neoplasms; Pyrroles; Random Allocation; Xenograft Model Antitumor Assays | 2013 |
Zebularine and scriptaid significantly improve epigenetic reprogramming of yak fibroblasts and cloning efficiency.
Topics: Animals; Cattle; Cell Proliferation; Cells, Cultured; Cellular Reprogramming; Cloning, Organism; Cytidine; Embryo Culture Techniques; Epigenesis, Genetic; Female; Fibroblasts; Histone Deacetylase Inhibitors; Hydroxylamines; Nuclear Transfer Techniques; Quinolines | 2013 |
Status epilepticus triggers early and late alterations in brain-derived neurotrophic factor and NMDA glutamate receptor Grin2b DNA methylation levels in the hippocampus.
Topics: Animals; Brain-Derived Neurotrophic Factor; Cytidine; DNA (Cytosine-5-)-Methyltransferases; DNA Methylation; Electroencephalography; Epilepsy, Temporal Lobe; Hippocampus; Kainic Acid; Male; Rats; Receptors, N-Methyl-D-Aspartate; Seizures; Status Epilepticus; Transcription Factor AP-2 | 2013 |
Zebularine induces long-term survival of pancreatic islet allotransplants in streptozotocin treated diabetic rats.
Topics: Animals; Blood Glucose; Cytidine; Diabetes Mellitus, Experimental; Gene Expression Regulation, Enzymologic; Graft Survival; Indoleamine-Pyrrole 2,3,-Dioxygenase; Islets of Langerhans Transplantation; Male; Rats; Rats, Inbred F344; Rats, Inbred Lew; Rats, Wistar; Reverse Transcriptase Polymerase Chain Reaction; Spleen; Time Factors; Transplantation, Homologous; Treatment Outcome | 2013 |
Treatment of fetal fibroblasts with DNA methylation inhibitors and/or histone deacetylase inhibitors improves the development of porcine nuclear transfer-derived embryos.
Topics: Animals; Cloning, Organism; Cytidine; DNA Methylation; Embryo Culture Techniques; Embryonic Development; Epigenomics; Fibroblasts; Histone Deacetylase Inhibitors; Nuclear Transfer Techniques; Phthalimides; Swine; Tryptophan | 2013 |
Zebularine induces chemosensitization to methotrexate and efficiently decreases AhR gene methylation in childhood acute lymphoblastic leukemia cells.
Topics: Antineoplastic Agents; Apoptosis; Basic Helix-Loop-Helix Transcription Factors; Cell Line, Tumor; Cytidine; DNA Modification Methylases; Drug Antagonism; Drug Resistance, Neoplasm; Drug Synergism; Humans; Methotrexate; Methylation; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Receptors, Aryl Hydrocarbon; Vincristine | 2014 |
Global DNA methylation analysis using methyl-sensitive amplification polymorphism (MSAP).
Topics: Arabidopsis; Azacitidine; Base Sequence; Cytidine; Decitabine; DNA Methylation; DNA, Plant; Polymerase Chain Reaction; Polymorphism, Genetic; Seeds | 2014 |
Zebularine inhibits tumorigenesis and stemness of colorectal cancer via p53-dependent endoplasmic reticulum stress.
Topics: Animals; Autophagy; Carcinogenesis; Cell Death; Cell Line; Cell Line, Tumor; Colorectal Neoplasms; Cytidine; DNA Damage; DNA Methylation; Down-Regulation; Endoplasmic Reticulum; Endoplasmic Reticulum Chaperone BiP; Endoplasmic Reticulum Stress; HCT116 Cells; HeLa Cells; Humans; Male; MCF-7 Cells; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Nude; Proto-Oncogene Proteins c-mdm2; Ribosomal Proteins; Signal Transduction; Tumor Suppressor Protein p53; Unfolded Protein Response; Up-Regulation | 2013 |
Zebularine significantly sensitises MEC1 cells to external irradiation and radiopharmaceutical therapy when administered sequentially in vitro.
Topics: Apoptosis; Cell Line, Tumor; Chemoradiotherapy; Cytidine; DNA (Cytosine-5-)-Methyltransferase 1; DNA (Cytosine-5-)-Methyltransferases; Humans; Neoplasms; Octreotide; Organometallic Compounds | 2014 |
Epigenetic reprogramming modulates malignant properties of human liver cancer.
Topics: Animals; Carcinogenesis; Carcinoma, Hepatocellular; Cell Line, Tumor; Cytidine; DNA (Cytosine-5-)-Methyltransferase 1; DNA (Cytosine-5-)-Methyltransferases; DNA Methylation; Gene Expression; Gene Knockdown Techniques; Humans; Liver Neoplasms; Mice; Mice, Inbred NOD; Mice, SCID; Neoplasms, Experimental; Neoplastic Stem Cells; Spheroids, Cellular | 2014 |
An epigenetic screen unmasks metallothioneins as putative contributors to renal cell carcinogenesis.
Topics: Adult; Aged; Biomarkers, Tumor; Carcinoma, Renal Cell; Cell Line, Tumor; Cell Transformation, Neoplastic; Cytidine; DNA Modification Methylases; Dose-Response Relationship, Drug; Enzyme Inhibitors; Epigenesis, Genetic; Female; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Humans; Kidney Neoplasms; Male; Metallothionein; Middle Aged; Oligonucleotide Array Sequence Analysis; Polymerase Chain Reaction; RNA, Messenger; Time Factors; Transcription, Genetic | 2015 |
DNA methyltransferase inhibitors improve the effect of chemotherapeutic agents in SW48 and HT-29 colorectal cancer cells.
Topics: Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Azacitidine; Cell Cycle; Cell Line, Tumor; Colorectal Neoplasms; Cytidine; Decitabine; DNA Damage; DNA-Cytosine Methylases; Enzyme Inhibitors; Fluorouracil; Humans; Membrane Potential, Mitochondrial; Organoplatinum Compounds; Oxaliplatin | 2014 |
Zebularine induces prolonged apoptosis effects via the caspase-3/PARP pathway in head and neck cancer cells.
Topics: Antineoplastic Agents; Apoptosis; Caspase 3; Cell Cycle; Cell Line, Tumor; Checkpoint Kinase 1; Cyclin-Dependent Kinase Inhibitor p21; Cytidine; Delayed-Action Preparations; DNA Methylation; Dose-Response Relationship, Drug; Gene Expression Regulation, Neoplastic; Head and Neck Neoplasms; Humans; Promoter Regions, Genetic; Protein Kinases; Signal Transduction | 2014 |
Processes of DNA methylation are involved in the mechanisms of amnesia induction and conditioned food aversion memory reconsolidation.
Topics: Amnesia; Animals; Conditioning, Psychological; Cytidine; Dizocilpine Maleate; DNA Methylation; DNA-Cytosine Methylases; Helix, Snails; Learning; Phthalimides; Receptors, N-Methyl-D-Aspartate; Tryptophan | 2014 |
Nucleoside transporters and human organic cation transporter 1 determine the cellular handling of DNA-methyltransferase inhibitors.
Topics: Animals; Azacitidine; Biological Transport; Cell Survival; Cytidine; Decitabine; DNA Modification Methylases; Dogs; HeLa Cells; Humans; Madin Darby Canine Kidney Cells; Nucleoside Transport Proteins; Oocytes; Organic Cation Transporter 1; Xenopus laevis | 2014 |
Demethylating drugs as novel analgesics for cancer pain.
Topics: Analgesics, Opioid; Animals; Antineoplastic Agents; Azacitidine; Carcinoma, Squamous Cell; Cytidine; Decitabine; Disease Models, Animal; DNA Methylation; Heterografts; Humans; Immunohistochemistry; In Situ Hybridization; Mice; Mouth Neoplasms; Neurons; Pain; Receptors, Opioid, mu; Reverse Transcriptase Polymerase Chain Reaction; Transduction, Genetic; Trigeminal Ganglion | 2014 |
Selected drugs that inhibit DNA methylation can preferentially kill p53 deficient cells.
Topics: Animals; Anticarcinogenic Agents; Azacitidine; Catechin; Cell Line, Tumor; Cell Proliferation; Cytidine; Decitabine; DNA Methylation; Humans; Lung Neoplasms; Mice; Mice, Inbred C57BL; Mice, Knockout; Mutation; Neoplasm Transplantation; Phthalimides; Tryptophan; Tumor Suppressor Protein p53; Xenograft Model Antitumor Assays | 2014 |
The role of DNA methylation in the mechanisms of memory reconsolidation and development of amnesia.
Topics: Amnesia; Animals; Avoidance Learning; Cytidine; DNA Methylation; DNA Modification Methylases; Enzyme Inhibitors; Helix, Snails; Memory, Long-Term; Phthalimides; Tryptophan | 2015 |
6-Thioguanine and zebularine down-regulate DNMT1 and globally demethylate canine malignant lymphoid cells.
Topics: Animals; Antineoplastic Agents; Apoptosis; Blotting, Western; Cell Line, Tumor; Cell Proliferation; Cytidine; DNA-Cytosine Methylases; Dog Diseases; Dogs; Dose-Response Relationship, Drug; Down-Regulation; Leukemia, B-Cell; Leukemia, T-Cell; Lymphoma; Thioguanine | 2014 |
Epidrug mediated re-expression of miRNA targeting the HMGA transcripts in pituitary cells.
Topics: Adenoma; Animals; Antineoplastic Agents; Cell Line; Chromatin Assembly and Disassembly; CpG Islands; Cytidine; DNA Methylation; Epigenesis, Genetic; Gene Expression Regulation, Neoplastic; Histone Deacetylase Inhibitors; HMGA Proteins; HMGA2 Protein; Humans; Hydroxamic Acids; MicroRNAs; Pituitary Gland; Pituitary Neoplasms; Rats; Rats, Sprague-Dawley; Up-Regulation | 2015 |
Characterization of a potato activation-tagged mutant, nikku, and its partial revertant.
Topics: 5-Methylcytosine; Biological Assay; Blotting, Southern; Cytidine; DNA Methylation; DNA, Bacterial; Enhancer Elements, Genetic; Gene Dosage; Gene Expression Regulation, Plant; Mutagenesis; Mutation; Phenotype; Plant Tubers; RNA, Messenger; Solanum tuberosum; Stress, Physiological | 2015 |
DNA methyltransferase inhibitor zebularine induces human cholangiocarcinoma cell death through alteration of DNA methylation status.
Topics: Antineoplastic Agents; Apoptosis; beta Catenin; Bile Duct Neoplasms; Cell Line, Tumor; Cell Proliferation; Cell Survival; Cholangiocarcinoma; CpG Islands; Cytidine; DNA (Cytosine-5-)-Methyltransferase 1; DNA (Cytosine-5-)-Methyltransferases; DNA Damage; DNA Methylation; Dose-Response Relationship, Drug; Enzyme Inhibitors; Gene Expression Regulation, Neoplastic; Gene Knockdown Techniques; Humans; Up-Regulation; Wnt Signaling Pathway | 2015 |
Brain feminization requires active repression of masculinization via DNA methylation.
Topics: Animals; Brain; Copulation; CpG Islands; Cytidine; Disorders of Sex Development; DNA (Cytosine-5-)-Methyltransferases; DNA Methylation; DNA Methyltransferase 3A; DNA, Intergenic; Estradiol; Female; Gene Expression Regulation, Developmental; Male; Mice; Microfilament Proteins; Nerve Tissue Proteins; Phthalimides; Preoptic Area; Protein Isoforms; Rats; Rats, Sprague-Dawley; Sex Characteristics; Sex Differentiation; Testosterone; Tryptophan | 2015 |
DNA Methylation Inhibitor Zebularine Confers Stroke Protection in Ischemic Rats.
Topics: Analysis of Variance; Animals; Brain Infarction; Cytidine; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme Inhibitors; Infarction, Middle Cerebral Artery; Male; Rats; Rats, Wistar; Reperfusion | 2015 |
G-quadruplex functionalized nano mesoporous silica for assay of the DNA methyltransferase activity.
Topics: Biosensing Techniques; Cytidine; DNA Methylation; DNA-Cytosine Methylases; Electrochemical Techniques; Enzyme Assays; G-Quadruplexes; Humans; Limit of Detection; Methylene Blue; Porosity; Silicon Dioxide | 2015 |
Repair of DNA Damage Induced by the Cytidine Analog Zebularine Requires ATR and ATM in Arabidopsis.
Topics: Arabidopsis; Arabidopsis Proteins; Ataxia Telangiectasia Mutated Proteins; Cell Cycle; Cytidine; DNA Damage; DNA Repair; DNA Replication | 2015 |
Pyrimidinone: versatile Trojan horse in DNA photodamage?
Topics: Cytidine; DNA; DNA Damage; Hydrogen; Light; Methanol; Molecular Structure; Photochemical Processes; Pyrimidinones; Spectrum Analysis; Water | 2015 |
Pharmacokinetics and toxicity of the novel oral demethylating agent zebularine in laboratory and tumor bearing dogs.
Topics: Administration, Oral; Aldehyde Oxidase; Animals; Chromatography, High Pressure Liquid; Cytidine; Cytosol; DNA Methylation; Dog Diseases; Dogs; Female; Half-Life; Indiana; Liver; Macrolides; Male; Neoplasms; Neutropenia; Schools, Veterinary | 2017 |
Instability of the Arabidopsis mutant csn5a-2 caused by epigenetic modification of intronic T-DNA.
Topics: Arabidopsis; Arabidopsis Proteins; Blotting, Western; COP9 Signalosome Complex; Cytidine; DNA Methylation; DNA, Bacterial; Epigenesis, Genetic; Gene Expression Regulation, Plant; Introns; Kanamycin Resistance; Mutagenesis, Insertional; Mutation; Phenotype; Protein Binding; rho GTP-Binding Proteins; RNA, Messenger; Two-Hybrid System Techniques | 2015 |
Dnmts and Tet target memory-associated genes after appetitive olfactory training in honey bees.
Topics: Animals; Bees; Cyclic AMP Response Element-Binding Protein; Cytidine; DNA; DNA (Cytosine-5-)-Methyltransferases; DNA Methylation; DNA-Binding Proteins; Epigenesis, Genetic; Memory, Long-Term; Phthalimides; Smell; Tryptophan; Up-Regulation | 2015 |
Exploring Synergy between Classic Mutagens and Antibiotics To Examine Mechanisms of Synergy and Antibiotic Action.
Topics: 2-Aminopurine; 4-Nitroquinoline-1-oxide; Anti-Bacterial Agents; Azacitidine; Bromodeoxyuridine; Chloramphenicol; Ciprofloxacin; Cytidine; DNA Breaks, Double-Stranded; Drug Synergism; Erythromycin; Escherichia coli; Gentamicins; Microbial Sensitivity Tests; Mutagens; Tetracycline; Trimethoprim; Vancomycin | 2015 |
Promoting effect of small molecules in cardiomyogenic and neurogenic differentiation of rat bone marrow-derived mesenchymal stem cells.
Topics: Animals; Bone Marrow Cells; Cell Differentiation; Cytidine; Mercaptoethanol; Mesenchymal Stem Cells; Myocytes, Cardiac; Neurons; Rats; Rats, Sprague-Dawley; RNA, Messenger | 2016 |
Creation of zebularine-resistant human cytidine deaminase mutants to enhance the chemoprotection of hematopoietic stem cells.
Topics: Amino Acid Sequence; Cytarabine; Cytidine; Cytidine Deaminase; Drug Resistance; Escherichia coli; Hematopoietic Stem Cell Transplantation; Humans; Mutagenesis; Mutation; Protein Engineering | 2016 |
Chromosome aberrations induced by zebularine in triticale.
Topics: Centromere; Chromosome Aberrations; Chromosome Deletion; Chromosomes, Plant; Cytidine; DNA Methylation; Genome, Plant; Seeds; Translocation, Genetic; Triticale; Triticum | 2016 |
A Comparative Analysis of 5-Azacytidine- and Zebularine-Induced DNA Demethylation.
Topics: Arabidopsis; Azacitidine; Cytidine; DNA Methylation; Gene Expression Regulation, Plant; Gene Silencing; Transcriptome | 2016 |
Mutagen Synergy: Hypermutability Generated by Specific Pairs of Base Analogs.
Topics: Azacitidine; Base Pairing; Bromodeoxyuridine; Cytidine; Drug Synergism; Escherichia coli; Escherichia coli Proteins; Mutagens; Mutation | 2016 |
CpG site methylation in CRYAA promoter affect transcription factor Sp1 binding in human lens epithelial cells.
Topics: Cells, Cultured; CpG Islands; Crystallins; Cytidine; DNA Methylation; Epithelial Cells; Humans; Lens, Crystalline; Promoter Regions, Genetic; Real-Time Polymerase Chain Reaction; RNA, Messenger; Sp1 Transcription Factor | 2016 |
Zebularine enhances apoptosis of human osteosarcoma cells by suppressing methylation of ARHI.
Topics: Apoptosis; Cell Line, Tumor; Cell Survival; CpG Islands; Cytidine; DNA (Cytosine-5-)-Methyltransferase 1; DNA (Cytosine-5-)-Methyltransferases; DNA Methylation; Epigenesis, Genetic; Gene Expression Regulation, Neoplastic; Gene Silencing; Histocompatibility Antigens; Histone-Lysine N-Methyltransferase; Humans; Osteosarcoma; Protein Binding; rho GTP-Binding Proteins | 2016 |
Inhibition of DNA methyltransferases regulates cocaine self-administration by rats: a genome-wide DNA methylation study.
Topics: Animals; Azacitidine; Brain; Cocaine; Cocaine-Related Disorders; CpG Islands; Cytidine; Decitabine; DNA; DNA Methylation; DNA Modification Methylases; Enzyme Inhibitors; Epigenesis, Genetic; Genome; Male; Phosphatidylinositol 3-Kinases; Promoter Regions, Genetic; Rats; Rats, Wistar; Reinforcement, Psychology; Self Administration | 2017 |
Suppression of iASPP-dependent aggressiveness in cervical cancer through reversal of methylation silencing of microRNA-124.
Topics: Base Sequence; Cell Line, Tumor; Cell Proliferation; Cytidine; DNA Methylation; Epithelial-Mesenchymal Transition; Female; Gene Expression Regulation, Neoplastic; Gene Silencing; Humans; Intracellular Signaling Peptides and Proteins; MicroRNAs; Models, Biological; Neoplasm Invasiveness; Neoplasm Metastasis; Neoplastic Stem Cells; Oncogenes; Phenotype; Protein Binding; Repressor Proteins; Transcription, Genetic; Tumor Suppressor Protein p53; Uterine Cervical Neoplasms | 2016 |
The DNA methyltransferase inhibitor zebularine exerts antitumor effects and reveals BATF2 as a poor prognostic marker for childhood medulloblastoma.
Topics: Adolescent; Adult; Antineoplastic Agents; Apoptosis; Basic-Leucine Zipper Transcription Factors; Biomarkers; Cell Cycle Proteins; Cell Line, Tumor; Cerebellar Neoplasms; Child; Child, Preschool; Cisplatin; Cytidine; DNA Modification Methylases; Drug Interactions; Female; Gene Expression Regulation, Neoplastic; Humans; Infant; Infant, Newborn; Male; Medulloblastoma; Oligonucleotide Array Sequence Analysis; Prognosis; Tumor Suppressor Proteins; Vincristine; Young Adult | 2017 |
Zebularine upregulates expression of CYP genes through inhibition of DNMT1 and PKR in HepG2 cells.
Topics: Apoptosis; Cyclophilins; Cytidine; DNA (Cytosine-5-)-Methyltransferase 1; DNA Methylation; eIF-2 Kinase; Gene Expression Regulation, Neoplastic; Hep G2 Cells; Hepatocytes; Humans | 2017 |
Neonatal Inhibition of DNA Methylation Alters Cell Phenotype in Sexually Dimorphic Regions of the Mouse Brain.
Topics: Animals; Animals, Newborn; Brain; Cytidine; DNA (Cytosine-5-)-Methyltransferase 1; DNA (Cytosine-5-)-Methyltransferases; DNA Methylation; Down-Regulation; Female; Male; Mice; Mice, Inbred C57BL; Neurons; Phenotype; Sex Characteristics; Sex Determination Processes; Time Factors | 2017 |
Effects of Zebularine on Invasion Activity and Intracellular Expression Level of let-7b in Colorectal Cancer Cells.
Topics: Cell Line, Tumor; Cell Proliferation; Colorectal Neoplasms; Cytidine; DNA Methylation; DNA Modification Methylases; Drug Resistance, Neoplasm; Enzyme Inhibitors; Exosomes; Humans; MicroRNAs; Neoplasm Invasiveness; Organoplatinum Compounds; Oxaliplatin; Transfection; Up-Regulation | 2017 |
Zebularine induces replication-dependent double-strand breaks which are preferentially repaired by homologous recombination.
Topics: Animals; Cell Line; Cricetulus; Cytidine; DNA; DNA Breaks, Double-Stranded; DNA Breaks, Single-Stranded; DNA Modification Methylases; DNA Repair; DNA Replication; Female; Recombinational DNA Repair | 2017 |
Prebiotic stereoselective synthesis of purine and noncanonical pyrimidine nucleotide from nucleobases and phosphorylated carbohydrates.
Topics: Adenine; Carbohydrates; Chromatography, High Pressure Liquid; Cytidine; Evolution, Chemical; Hypoxanthine; Magnetic Resonance Spectroscopy; Organophosphates; Origin of Life; Phosphorylation; Purine Nucleotides; Pyrimidine Nucleotides | 2017 |
Zebularine treatment is associated with deletion of FT-B1 leading to an increase in spikelet number in bread wheat.
Topics: Bread; Cytidine; DNA Methylation; Flowers; Gene Deletion; Gene Expression Regulation, Plant; Genes, Plant; Genomics; Inheritance Patterns; Mutation; Plant Dormancy; Temperature; Triticum | 2018 |
Zebularine exerts its antiproliferative activity through S phase delay and cell death in human malignant mesothelioma cells.
Topics: Apoptosis; Cell Line, Tumor; Cell Proliferation; Cytidine; DNA (Cytosine-5-)-Methyltransferase 1; Dose-Response Relationship, Drug; Fibroblasts; Glyceraldehyde-3-Phosphate Dehydrogenases; Humans; Mesothelioma; S Phase; Tumor Suppressor Protein p53 | 2018 |
Effect of DNA and Histone Methyl Transferase Inhibitors on Outcomes of Buffalo-Bovine Interspecies Somatic Cell Nuclear Transfer.
Topics: Acetylation; Animals; Azepines; Blastocyst; Buffaloes; Cattle; Cell Survival; Cells, Cultured; Cellular Reprogramming; Cytidine; DNA; DNA Modification Methylases; Embryo, Mammalian; Embryonic Development; Epigenesis, Genetic; Female; Histone-Lysine N-Methyltransferase; Histones; Nuclear Transfer Techniques; Quinazolines | 2018 |
Telomere elongation upon transfer to callus culture reflects the reprogramming of telomere stability control in Arabidopsis.
Topics: Arabidopsis; Arabidopsis Proteins; Chromatin; Cytidine; Ecotype; Epigenesis, Genetic; Genes, Plant; Histones; Mutation; Nicotiana; Regeneration; RNA, Messenger; Species Specificity; Telomerase; Telomere; Telomere Homeostasis; Tissue Culture Techniques | 2018 |
Zebularine significantly improves the preimplantation development of ovine somatic cell nuclear transfer embryos.
Topics: Animals; Cellular Reprogramming; Cytidine; DNA Methylation; Embryonic Development; Enzyme Inhibitors; Female; Methyltransferases; Nanog Homeobox Protein; Nuclear Transfer Techniques; Octamer Transcription Factor-3; Promoter Regions, Genetic; Sheep; SOXB1 Transcription Factors | 2019 |
Translation of non-standard codon nucleotides reveals minimal requirements for codon-anticodon interactions.
Topics: 2-Aminopurine; Anticodon; Bacteriophage T7; Base Sequence; Codon; Cytidine; DNA-Directed RNA Polymerases; Escherichia coli; HEK293 Cells; Humans; Hydrogen Bonding; Inosine; Protein Biosynthesis; Pyridones; Receptor, Serotonin, 5-HT2C; Ribosomes; RNA, Transfer, Gly; Viral Proteins | 2018 |
Continuous zebularine treatment enhances hepatic differentiation of mesenchymal stem cells under liver-specific factors induction in vitro.
Topics: Animals; Bone Marrow Cells; Cell Differentiation; Culture Media; Cytidine; DNA Methylation; Flow Cytometry; Gene Expression Profiling; Glycogen; Immunophenotyping; Liver; Mesenchymal Stem Cells; Rabbits; Time Factors; Urea | 2018 |
A Dual-Bioresponsive Drug-Delivery Depot for Combination of Epigenetic Modulation and Immune Checkpoint Blockade.
Topics: Animals; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Calcium Carbonate; Cell Line, Tumor; Cytidine; Drug Delivery Systems; Drug Liberation; Drug Therapy, Combination; Humans; Hydrogen-Ion Concentration; Immunosuppressive Agents; Immunotherapy; Melanoma; Nanoparticles; Programmed Cell Death 1 Receptor; Reactive Oxygen Species; Tumor Microenvironment | 2019 |
A requirement for epigenetic modifications during noradrenergic stabilization of heterosynaptic LTP in the hippocampus.
Topics: Adrenergic beta-Antagonists; Animals; CA1 Region, Hippocampal; Cytidine; DNA Methylation; Epigenesis, Genetic; Excitatory Postsynaptic Potentials; Histone Acetyltransferases; Histone Deacetylase Inhibitors; Long-Term Potentiation; Male; Mice; Mice, Inbred C57BL; Norepinephrine; Propranolol; Receptors, Adrenergic, beta; Signal Transduction | 2019 |
Enhancement of epigenetic reprogramming status of porcine cloned embryos with zebularine, a DNA methyltransferase inhibitor.
Topics: Animals; Cellular Reprogramming; Cloning, Organism; Cytidine; DNA Modification Methylases; Embryo, Mammalian; Enzyme Inhibitors; Epigenesis, Genetic; Swine | 2019 |
Epigenetic inhibitor zebularine activates ear pinna wound closure in the mouse.
Topics: Animals; Biomarkers; Cell Proliferation; CpG Islands; Cytidine; DNA Methylation; Ear Auricle; Epigenesis, Genetic; Keratinocytes; Mice; Regenerative Medicine; Tretinoin; Wound Healing | 2019 |
Pharmacological manipulation of DNA methylation normalizes maternal behavior, DNA methylation, and gene expression in dams with a history of maltreatment.
Topics: Animals; Animals, Newborn; Behavior, Animal; Brain-Derived Neurotrophic Factor; Cytidine; DNA Methylation; Female; Gene Expression Regulation; Male; Maternal Behavior; Preoptic Area; Rats, Long-Evans; Sex Ratio | 2019 |
The DNA Methylation Inhibitor Zebularine Controls CD4
Topics: Animals; Autoimmune Diseases; CD4-Positive T-Lymphocytes; Cells, Cultured; Cytidine; DNA Methylation; Female; Forkhead Transcription Factors; Humans; Inflammation; Interferon-gamma; Interleukin-17; Mice; Mice, Inbred C57BL; Principal Component Analysis; Uveitis | 2019 |
Metabolic targeting of HIF-1α potentiates the therapeutic efficacy of oxaliplatin in colorectal cancer.
Topics: Animals; Antineoplastic Agents; Colorectal Neoplasms; Cytidine; Down-Regulation; Drug Resistance, Neoplasm; Drug Synergism; Female; Gene Expression Regulation, Neoplastic; HCT116 Cells; Humans; Hydroxylation; Hypoxia-Inducible Factor 1, alpha Subunit; Mice; Molecular Targeted Therapy; Neovascularization, Pathologic; Oxaliplatin; Protein Stability; Proteolysis; Vascular Endothelial Growth Factor A; Xenograft Model Antitumor Assays | 2020 |
Comparative analysis of epigenetic inhibitors reveals different degrees of interference with transcriptional gene silencing and induction of DNA damage.
Topics: Adenosine; Arabidopsis; Azacitidine; Chromosome Aberrations; Cytidine; Decitabine; DNA Damage; DNA Methylation; DNA Repair; Epigenesis, Genetic; Gene Silencing; Heterochromatin; RNA Interference; Tandem Repeat Sequences | 2020 |
Neonatal Inhibition of DNA Methylation Disrupts Testosterone-Dependent Masculinization of Neurochemical Phenotype.
Topics: Animals; Animals, Newborn; Brain; Brain Chemistry; Calbindins; Cytidine; DNA Methylation; Estrogen Receptor alpha; Female; Kisspeptins; Male; Mice, Inbred C57BL; Neurons; Sex Differentiation; Sex Factors; Testosterone | 2020 |
A plant pentatricopeptide repeat protein with a DYW-deaminase domain is sufficient for catalyzing C-to-U RNA editing
Topics: Adenosine Triphosphate; Biocatalysis; Bryopsida; Cytidine; Cytosine; Ions; Magnesium; Mutation; Plant Extracts; Plant Proteins; Protein Aggregates; Protein Domains; Protein Multimerization; Recombinant Proteins; Repetitive Sequences, Amino Acid; RNA Editing; Substrate Specificity; Temperature; Tetrahydrouridine; Uracil; Zea mays; Zinc | 2020 |
Zebularine-induced myeloma cell death is accompanied by decreased c-Myc expression.
Topics: Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cell Proliferation; Cytidine; DNA Methylation; Humans; Multiple Myeloma; Proto-Oncogene Proteins c-myc | 2020 |
Activation of SIRT6 by DNA hypomethylating agents and clinical consequences on combination therapy in leukemia.
Topics: Acetylation; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Azacitidine; Bone Marrow; Cell Line, Tumor; Cytidine; Decitabine; DNA Methylation; Histones; Humans; Leukemia, Myeloid, Acute; Sirtuins | 2020 |
Investigation of the Effect of Zebularine in Comparison to and in Combination with Trichostatin A on p21Cip1/Waf1/ Sdi1, p27Kip1, p57Kip2, DNA Methyltransferases and Histone Deacetylases in Colon Cancer LS 180 Cell Line.
Topics: Biomarkers, Tumor; Cell Proliferation; Colonic Neoplasms; Cyclin-Dependent Kinase Inhibitor p21; Cyclin-Dependent Kinase Inhibitor p27; Cyclin-Dependent Kinase Inhibitor p57; Cytidine; Gene Expression Regulation, Neoplastic; Histone Deacetylases; Humans; Methyltransferases; Tumor Cells, Cultured | 2020 |
Effect of Zebularine in Comparison to and in Combination with Trichostatin A on CIP/KIP Family (p21Cip1/Waf1/Sdi1, p27Kip1, and p57Kip2), DNMTs (DNMT1, DNMT3a, and DNMT3b), Class I HDACs (HDACs 1, 2, 3) and Class II HDACs (HDACs 4, 5, 6) Gene Expression,
Topics: Apoptosis; Biomarkers, Tumor; Calcium-Binding Proteins; Cell Proliferation; Colonic Neoplasms; Cyclin-Dependent Kinase Inhibitor p21; Cytidine; DNA (Cytosine-5-)-Methyltransferases; Gene Expression Regulation, Neoplastic; Histone Deacetylase Inhibitors; Histone Deacetylases; Humans; Hydroxamic Acids; Tumor Cells, Cultured | 2020 |
The effect of zebularine on the heat-activated retrotransposon ONSEN in Arabidopsis thaliana and Vigna angularis.
Topics: Arabidopsis; Cytidine; DNA Methylation; DNA Transposable Elements; Heat-Shock Response; Vigna | 2020 |
Effect of valproic acid and zebularine on SOCS-1 and SOCS-3 gene expression in colon carcinoma SW48 cell line.
Topics: Apoptosis; Cell Line, Tumor; Cell Proliferation; Cell Survival; Cells, Cultured; Colonic Neoplasms; Cytidine; Dose-Response Relationship, Drug; Flow Cytometry; Gene Expression Regulation, Neoplastic; Humans; Suppressor of Cytokine Signaling 1 Protein; Suppressor of Cytokine Signaling 3 Protein; Valproic Acid | 2020 |
Distinct Responses of Arabidopsis Telomeres and Transposable Elements to Zebularine Exposure.
Topics: Arabidopsis; Cytidine; Cytosine; DNA Methylation; DNA Transposable Elements; Epigenesis, Genetic; Plant Cells; Telomere; Telomere Homeostasis; Telomere Shortening; Transcriptional Activation | 2021 |
Zebularine elevates STING expression and enhances cGAMP cancer immunotherapy in mice.
Topics: Administration, Oral; Animals; CD8-Positive T-Lymphocytes; Cell Line, Tumor; Cell Proliferation; Cell Survival; Cytidine; Drug Synergism; Humans; Killer Cells, Natural; Melanoma, Experimental; Membrane Proteins; Mice; Mice, Nude; Nucleotides, Cyclic; Nucleotidyltransferases; Promoter Regions, Genetic; THP-1 Cells; Tumor Microenvironment; Xenograft Model Antitumor Assays | 2021 |
Zebularine suppressed gemcitabine-induced senescence and improved the cellular and plasma pharmacokinetics of gemcitabine, augmented by liposomal co-delivery.
Topics: Animals; Cell Line, Tumor; Cytidine; Deoxycytidine; Drug Resistance, Neoplasm; Gemcitabine; Liposomes; Pancreatic Neoplasms; Rats | 2021 |
In vitro assessment of a synergistic combination of gemcitabine and zebularine in pancreatic cancer cells.
Topics: Antimetabolites, Antineoplastic; Apoptosis Regulatory Proteins; Carcinoma, Pancreatic Ductal; Cell Line, Tumor; Cytidine; Cytidine Deaminase; Deoxycytidine; Gemcitabine; Humans; Pancreas; Pancreatic Neoplasms | 2021 |
Genomic impact of stress-induced transposable element mobility in Arabidopsis.
Topics: Arabidopsis; Arabidopsis Proteins; Cytidine; Epigenesis, Genetic; Exons; Gene Expression Regulation, Plant; Genome, Plant; Heat-Shock Response; Histone Code; Histones; Phenotype; Retroelements; Transcriptome | 2021 |
Combination of epigenetic regulation with gene therapy-mediated immune checkpoint blockade induces anti-tumour effects and immune response in vivo.
Topics: Animals; B7-H1 Antigen; Cell Line, Tumor; Combined Modality Therapy; Cytidine; DNA Methylation; Epigenesis, Genetic; Genetic Therapy; Humans; Immune Checkpoint Inhibitors; Immunity; Immunotherapy; Methyltransferases; Neoplasm Metastasis; Neoplasms; T-Lymphocytes; Tumor Escape; Tumor Microenvironment | 2021 |
Zebularine induces enzymatic DNA-protein crosslinks in 45S rDNA heterochromatin of Arabidopsis nuclei.
Topics: Arabidopsis; Arabidopsis Proteins; Cell Cycle Proteins; Cytidine; DNA (Cytosine-5-)-Methyltransferases; DNA-Binding Proteins; Drug Resistance; Heterochromatin; Membrane Transport Proteins; Mutagens; Mutation; RNA, Ribosomal; Transcription Factors | 2022 |
Zebularine protects against blood-brain-barrier (BBB) disruption through increasing the expression of zona occludens-1 (ZO-1) and vascular endothelial (VE)-cadherin.
Topics: AMP-Activated Protein Kinases; Animals; Blood-Brain Barrier; Cadherins; Cytidine; Endothelium, Vascular; Inflammation; Mice; Protective Agents; Stroke; Zonula Occludens-1 Protein | 2022 |
Possible Involvement of DNA Methylation and Protective Effect of Zebularine on Neuronal Cell Death after Glutamate Excitotoxity.
Topics: Brain Ischemia; Cell Death; Cytidine; DNA Methylation; Glutamic Acid; Humans; Receptors, N-Methyl-D-Aspartate; RNA, Small Interfering | 2022 |
Role of Wnt/β-catenin pathway in cardiac lineage commitment of human umbilical cord mesenchymal stem cells by zebularine and 2'-deoxycytidine.
Topics: beta Catenin; Cell Differentiation; Cytidine; Deoxycytidine; Humans; Mesenchymal Stem Cells; Myocytes, Cardiac; Umbilical Cord; Wnt Signaling Pathway | 2022 |
Zebularine, a DNA Methylation Inhibitor, Activates Anthocyanin Accumulation in Grapevine Cells.
Topics: Anthocyanins; Cytidine; DNA Methylation; Gene Expression Regulation, Plant; Plant Proteins | 2022 |