Page last updated: 2024-08-17

cytidine and n(4)-hydroxycytidine

cytidine has been researched along with n(4)-hydroxycytidine in 31 studies

Research

Studies (31)

Timeframe	Studies, this research(%)	All Research%
pre-1990	4 (12.90)	18.7374
1990's	1 (3.23)	18.2507
2000's	5 (16.13)	29.6817
2010's	6 (19.35)	24.3611
2020's	15 (48.39)	2.80

Authors

Authors	Studies
Glickman, BW; Janion, C	1
Janion, C; Sledziewska-Gójska, E	2
Janion, C; Sledziewska, E	1
Brockman, HE; de Serres, FJ	1
Chu, CK; Hernandez-Santiago, BI; Jordan, R; Lostia, S; McBrayer, TR; Otto, MJ; Rachakonda, S; Ramesh, M; Schinazi, RF; Shi, J; Stuyver, LJ; Tharnish, PM; Watanabe, KA; Whitaker, T	1
Loakes, D; Maehara, D; Nakamura, S; Negishi, K; Negishi, T; Schaaper, RM; Seio, K; Sekine, M; Worth, L	1
Barnard, DL; Burton, J; Hubbard, VD; Morrey, JD; Otto, MJ; Sidwell, RW; Smee, DF	1
Beltran, T; Chu, CK; Hernandez-Santiago, BI; Schinazi, RF; Stuyver, L	1
Berkhout, B; Bosch, BJ; Dijkman, R; Jebbink, MF; Pyrc, K; Rottier, P; van der Hoek, L	1
Barclay, L; Costantini, VP; Lee, D; McBrayer, TR; Schinazi, RF; Vinjé, J; Whitaker, T	1
Bittner, F; Clement, B; Garbe-Schönberg, D; Havemeyer, A; Krischkowski, C; Krompholz, N; Mendel, RR; Reichmann, D	1
Alazard-Dany, N; Barateau, V; Cimarelli, A; Nguyen, XN; Reynard, O; Volchkov, VE	1
Amblard, F; Ehteshami, M; Hammond, E; Hsiao, HM; Jiang, Y; Merits, A; Russell, OO; Schinazi, RF; Tao, S; Zandi, K	1
Crossman, DK; Crowley, MR; Frolov, I; Frolova, EI; Guthrie, DB; Kolykhalov, AA; Kuznetsova, V; Lockwood, MA; Natchus, MG; Painter, GR; Sokratian, A; Urakova, N	1
Agostini, ML; Andres, EL; Baric, RS; Bluemling, GR; Chappell, JD; Denison, MR; Gribble, J; Kolykhalov, AA; Lockwood, MA; Lu, X; Natchus, MG; Painter, GR; Pruijssers, AJ; Saindane, M; Sheahan, TP; Sims, AC	1
Bluemling, GR; Guthrie, DB; Kolykhalov, AA; Lu, G; Marlow, J; Mitchell, DG; Moellering, L; Natchus, MG; Painter, GR; Sticher, ZM	1
Hampton, T	1
Agostini, ML; Baric, RS; Bluemling, GR; Brown, AJ; Chappell, JD; Denison, MR; Dinnon, KH; George, AS; Graham, RL; Harcourt, J; Hill, CS; Hughes, TM; Kolykhalov, AA; Leist, SR; Lu, X; Montgomery, SA; Natchus, MG; Painter, G; Pruijssers, AJ; Saindane, M; Schäfer, A; Sheahan, TP; Sims, AC; Stevens, LJ; Swanstrom, R; Tamin, A; Thornburg, NJ; Zhou, S	1
Baric, RS; Heise, MT; Hill, CS; Sarkar, S; Schinazi, RF; Sheahan, TP; Swanstrom, R; Tse, LV; Woodburn, BMD; Zhou, S	1
Gordon, CJ; Götte, M; Schinazi, RF; Tchesnokov, EP	1
Cherrington, NJ; Ekins, S; McGrath, ME; Miller, SR; Wright, SH; Zorn, KM	2
Kryszak, LA; Marzinke, MA; Parsons, TL	1
Hughes, C; Lewis, P; Warren, S; Waters, MD; Zhang, F	1
André, E; Chiu, W; De Jonghe, S; Jochmans, D; Leyssen, P; Maes, P; Neyts, J; Raymenants, J; Slechten, B; Vangeel, L	1
Johnson, EK	1
Schinazi, RF; Swanstrom, R	1
Amara, A; Bullock, K; Dickinson, L; Else, L; Ewings, S; FitzGerald, R; Fletcher, T; Greenhalf, W; Griffiths, G; Hale, C; Holman, W; Khoo, S; Lavelle-Langham, L; Lyon, R; Painter, W; Penchala, SD; Reynolds, H; Shaw, V; Walker, L	1
Cao, R; Chen, X; Dai, Q; Guo, X; Li, W; Li, Y; Liu, M; Wang, Z; Yan, Y; Yang, X; Zhong, W	1
Ahmed, A; Bhardwaj, M; Dhiman, S; Gour, A; Khajuria, P; Manhas, D; Mukherjee, D; Nandi, U; Wazir, P	1

Reviews

1 review(s) available for cytidine and n(4)-hydroxycytidine

Article	Year
Human genetic risk of treatment with antiviral nucleoside analog drugs that induce lethal mutagenesis: The special case of molnupiravir. Environmental and molecular mutagenesis, 2022, Volume: 63, Issue:1 Topics: Amides; Antiviral Agents; COVID-19 Drug Treatment; Cytidine; Deoxyuridine; DNA Damage; Genome, Human; Humans; Hydroxylamines; Mutagenesis; Nucleosides; Pyrazines; Ribavirin; SARS-CoV-2	2022

Trials

1 trial(s) available for cytidine and n(4)-hydroxycytidine

Article	Year
Pharmacokinetics of ß-d-N4-Hydroxycytidine, the Parent Nucleoside of Prodrug Molnupiravir, in Nonplasma Compartments of Patients With Severe Acute Respiratory Syndrome Coronavirus 2 Infection. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2022, 08-24, Volume: 75, Issue:1 Topics: Antiviral Agents; COVID-19 Drug Treatment; Cytidine; Humans; Hydroxylamines; Nucleosides; Parents; Prodrugs; SARS-CoV-2	2022

Article

Year

Pharmacokinetics of ß-d-N4-Hydroxycytidine, the Parent Nucleoside of Prodrug Molnupiravir, in Nonplasma Compartments of Patients With Severe Acute Respiratory Syndrome Coronavirus 2 Infection.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2022, 08-24, Volume: 75, Issue:1

Topics: Antiviral Agents; COVID-19 Drug Treatment; Cytidine; Humans; Hydroxylamines; Nucleosides; Parents; Prodrugs; SARS-CoV-2

2022

Other Studies

29 other study(ies) available for cytidine and n(4)-hydroxycytidine

Article	Year
N4-hydroxycytidine: a mutagen specific for AT to GC transitions. Mutation research, 1980, Volume: 72, Issue:1 Topics: Cytidine; DNA Repair; DNA-Directed DNA Polymerase; DNA, Bacterial; Escherichia coli; Lac Operon; Mutagens; RNA Polymerase I; RNA, Bacterial; Substrate Specificity	1980
Do DNA repair systems affect N4-hydroxycytidine-induced mutagenesis? Acta biochimica Polonica, 1983, Volume: 30, Issue:2 Topics: Cytidine; DNA Repair; Drug Resistance, Microbial; Escherichia coli; Lysogeny; Mutagens; Rifampin	1983
Effect of proofreading and dam-instructed mismatch repair systems on N4-hydroxycytidine-induced mutagenesis. Molecular & general genetics : MGG, 1982, Volume: 186, Issue:3 Topics: Alleles; Cytidine; DNA Ligases; DNA Repair; Escherichia coli; Exodeoxyribonuclease V; Exodeoxyribonucleases; Mutagens; Mutation	1982
Mutagenic specificity of N4-hydroxycytidine. Mutation research, 1980, Volume: 70, Issue:1 Topics: Base Sequence; Cytidine; DNA, Viral; Gene Frequency; Mutagens; Mutation; T-Phages	1980
Comparison of the spectra of genetic damage in N4-hydroxycytidine-induced ad-3 mutations between nucleotide excision repair-proficient and -deficient heterokaryons of Neurospora crassa. Mutation research, 1993, Volume: 285, Issue:2 Topics: Adenine; Alleles; Cytidine; Databases, Bibliographic; DNA Damage; DNA Repair; Escherichia coli; Genetic Complementation Test; Genotype; Mutagens; Mutation; Neurospora crassa	1993
Ribonucleoside analogue that blocks replication of bovine viral diarrhea and hepatitis C viruses in culture. Antimicrobial agents and chemotherapy, 2003, Volume: 47, Issue:1 Topics: Animals; Antiviral Agents; Cattle; Cells, Cultured; Cytidine; Diarrhea Viruses, Bovine Viral; Female; Hepacivirus; Mice; RNA, Viral; Virus Replication	2003
Binding specificities of the mismatch binding protein, MutS, to oligonucleotides containing modified bases. Nucleic acids research. Supplement (2001), 2001, Issue:1 Topics: 2-Aminopurine; Adenosine Triphosphatases; Bacterial Proteins; Base Pair Mismatch; Base Sequence; Cytidine; Deoxyribonucleosides; DNA-Binding Proteins; Escherichia coli Proteins; MutS DNA Mismatch-Binding Protein; Nucleic Acid Heteroduplexes; Oligonucleotides	2001
Inhibition of severe acute respiratory syndrome-associated coronavirus (SARSCoV) by calpain inhibitors and beta-D-N4-hydroxycytidine. Antiviral chemistry & chemotherapy, 2004, Volume: 15, Issue:1 Topics: Animals; Chlorocebus aethiops; Cytidine; Glycoproteins; Molecular Structure; Nucleosides; Severe Acute Respiratory Syndrome; Severe acute respiratory syndrome-related coronavirus; Vero Cells; Virus Replication	2004
Metabolism of the anti-hepatitis C virus nucleoside beta-D-N4-hydroxycytidine in different liver cells. Antimicrobial agents and chemotherapy, 2004, Volume: 48, Issue:12 Topics: Alkaline Phosphatase; Animals; Antiviral Agents; Biotransformation; Cell Line; Chromatography, High Pressure Liquid; Cytidine; Half-Life; Haplorhini; Hepacivirus; Hepatocytes; Humans; In Vitro Techniques; Liver; Mass Spectrometry; Nucleosides	2004
Inhibition of human coronavirus NL63 infection at early stages of the replication cycle. Antimicrobial agents and chemotherapy, 2006, Volume: 50, Issue:6 Topics: Animals; Antiviral Agents; Azauridine; Base Sequence; Cell Line; Cell Survival; Coronavirus; Coronavirus Infections; Cytidine; Cytopathogenic Effect, Viral; Humans; Inhibitory Concentration 50; Macaca mulatta; Molecular Structure; Neutralization Tests; Nucleosides; Receptors, Virus; RNA Interference; RNA, Small Interfering; RNA, Viral; Time Factors; Virus Replication	2006
Antiviral activity of nucleoside analogues against norovirus. Antiviral therapy, 2012, Volume: 17, Issue:6 Topics: Animals; Antiviral Agents; Cell Line, Tumor; Cytidine; Deoxycytidine; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Drug Synergism; Gastroenteritis; Humans; Lamivudine; Mice; Norovirus; Ribavirin; RNA, Viral; Time Factors; Virus Replication	2012
The mitochondrial Amidoxime Reducing Component (mARC) is involved in detoxification of N-hydroxylated base analogues. Chemical research in toxicology, 2012, Nov-19, Volume: 25, Issue:11 Topics: Adenine; Biocatalysis; Cytidine; Cytosine; Humans; Mitochondrial Proteins; Oxidation-Reduction; Oxidoreductases; Recombinant Proteins	2012
Identification of a New Ribonucleoside Inhibitor of Ebola Virus Replication. Viruses, 2015, Dec-01, Volume: 7, Issue:12 Topics: Animals; Antiviral Agents; Chlorocebus aethiops; Cytidine; Ebolavirus; Vero Cells; Virus Replication	2015
Characterization of β-d- Antimicrobial agents and chemotherapy, 2017, Volume: 61, Issue:4 Topics: Animals; Antiviral Agents; Cell Line; Chikungunya virus; Cytidine; Humans; Virus Replication	2017
β-d- Journal of virology, 2018, 02-01, Volume: 92, Issue:3 Topics: Alphavirus; Animals; Antiviral Agents; Cell Line; Chlorocebus aethiops; Cricetinae; Cytidine; Genome, Viral; Humans; Mutation; Ribavirin; Vero Cells; Viral Load; Viral Nonstructural Proteins	2018
Small-Molecule Antiviral β-d- Journal of virology, 2019, 12-15, Volume: 93, Issue:24 Topics: Animals; Antiviral Agents; Cell Line; Cell Line, Tumor; Chlorocebus aethiops; Coronaviridae Infections; Coronavirus Infections; Cytidine; Drug Resistance, Viral; Exoribonucleases; Mice; Middle East Respiratory Syndrome Coronavirus; Murine hepatitis virus; Mutagenesis; RNA-Dependent RNA Polymerase; Vero Cells; Viral Nonstructural Proteins; Virus Replication	2019
Analysis of the Potential for Antimicrobial agents and chemotherapy, 2020, 01-27, Volume: 64, Issue:2 Topics: Cell Survival; Culture Media; Cytidine; DNA-Directed RNA Polymerases; DNA, Mitochondrial; Gene Dosage; Hep G2 Cells; Humans; Lactic Acid; Mitochondria, Liver; Phosphates	2020
New Flu Antiviral Candidate May Thwart Drug Resistance. JAMA, 2020, Jan-07, Volume: 323, Issue:1 Topics: Animals; Antiviral Agents; Cytidine; Disease Models, Animal; Drug Resistance, Viral; Humans; Hydroxylamines; Influenza, Human; Macaca; Ribonucleosides	2020
An orally bioavailable broad-spectrum antiviral inhibits SARS-CoV-2 in human airway epithelial cell cultures and multiple coronaviruses in mice. Science translational medicine, 2020, 04-29, Volume: 12, Issue:541 Topics: Adenosine Monophosphate; Alanine; Animals; Antibiotic Prophylaxis; Antiviral Agents; Betacoronavirus; Cell Line; Coronavirus Infections; COVID-19; Cytidine; Disease Models, Animal; Drug Resistance, Viral; Humans; Hydroxylamines; Lung; Mice; Mice, Inbred C57BL; Middle East Respiratory Syndrome Coronavirus; Models, Molecular; Mutation; Pandemics; Pneumonia, Viral; Primary Cell Culture; Random Allocation; Respiratory System; Ribonucleosides; RNA-Dependent RNA Polymerase; RNA, Viral; SARS-CoV-2; Virus Replication	2020
β-d-N4-hydroxycytidine Inhibits SARS-CoV-2 Through Lethal Mutagenesis But Is Also Mutagenic To Mammalian Cells. The Journal of infectious diseases, 2021, 08-02, Volume: 224, Issue:3 Topics: Animals; Antiviral Agents; Cells, Cultured; CHO Cells; Cricetulus; Cytidine; Dose-Response Relationship, Drug; Mutagenesis; Mutagens; SARS-CoV-2; Virus Replication	2021
Molnupiravir promotes SARS-CoV-2 mutagenesis via the RNA template. The Journal of biological chemistry, 2021, Volume: 297, Issue:1 Topics: Antiviral Agents; COVID-19; Cytidine; Humans; Hydroxylamines; Mutagenesis; Point Mutation; RNA, Viral; SARS-CoV-2	2021
Remdesivir and EIDD-1931 Interact with Human Equilibrative Nucleoside Transporters 1 and 2: Implications for Reaching SARS-CoV-2 Viral Sanctuary Sites. Molecular pharmacology, 2021, Volume: 100, Issue:6 Topics: Adenosine Monophosphate; Alanine; Antiviral Agents; COVID-19; COVID-19 Drug Treatment; Cytidine; Dose-Response Relationship, Drug; Drug Interactions; Equilibrative Nucleoside Transporter 1; Equilibrative-Nucleoside Transporter 2; HeLa Cells; Humans; Protein Binding; SARS-CoV-2	2021
Development and validation of assays for the quantification of β-D-N Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2021, Oct-01, Volume: 1182 Topics: Cytidine; Humans; Reproducibility of Results	2021
Remdesivir, Molnupiravir and Nirmatrelvir remain active against SARS-CoV-2 Omicron and other variants of concern. Antiviral research, 2022, Volume: 198 Topics: Adenosine; Adenosine Monophosphate; Alanine; Animals; Antiviral Agents; Cell Line; Chlorocebus aethiops; Coronavirus 3C Proteases; COVID-19 Drug Treatment; Cytidine; Humans; Hydroxylamines; Lactams; Leucine; Microbial Sensitivity Tests; Nitriles; Proline; RNA-Dependent RNA Polymerase; SARS-CoV-2; Vero Cells; Virus Replication	2022
A Comment on "Remdesivir and EIDD-1931 Interact with Human Equilibrative Nucleoside Transporters 1 and 2: Implications for Reaching SARS-CoV-2 Viral Sanctuary Sites". Molecular pharmacology, 2022, Volume: 101, Issue:2 Topics: Adenosine Monophosphate; Alanine; COVID-19 Drug Treatment; Cytidine; Humans; Nucleosides; SARS-CoV-2	2022
Response to Comments on "Remdesivir and EIDD-1931 Interact with Human Equilibrative Nucleoside Transporters 1 and 2: Implications for Reaching SARS-CoV-2 Viral Sanctuary Sites". Molecular pharmacology, 2022, Volume: 101, Issue:2 Topics: Adenosine Monophosphate; Alanine; COVID-19 Drug Treatment; Cytidine; Humans; Nucleosides; SARS-CoV-2	2022
Lethal mutagenesis as an antiviral strategy. Science (New York, N.Y.), 2022, Feb-04, Volume: 375, Issue:6580 Topics: Animals; Antiviral Agents; COVID-19; COVID-19 Drug Treatment; Cytidine; DNA; Evolution, Molecular; Genome, Viral; Humans; Hydroxylamines; Mutagenesis; Mutagenicity Tests; Phosphorylation; Ribonucleosides; RNA Virus Infections; RNA Viruses; RNA, Viral; SARS-CoV-2	2022
Molnupiravir and Its Active Form, EIDD-1931, Show Potent Antiviral Activity against Enterovirus Infections In Vitro and In Vivo. Viruses, 2022, 05-25, Volume: 14, Issue:6 Topics: Animals; Antigens, Viral; Antiviral Agents; Child, Preschool; COVID-19; Cytidine; Enterovirus; Enterovirus A, Human; Enterovirus Infections; Humans; Hydroxylamines; Mice; Mice, Inbred ICR	2022
Impact of Disease States on the Oral Pharmacokinetics of EIDD-1931 (an Active Form of Molnupiravir) in Rats for Implication in the Dose Adjustment. Molecular pharmaceutics, 2023, 09-04, Volume: 20, Issue:9 Topics: Animals; COVID-19; Cytidine; Hydroxylamines; Rats	2023