Page last updated: 2024-08-17

cytidine and cyclopentenyl cytosine

cytidine has been researched along with cyclopentenyl cytosine in 63 studies

Research

Studies (63)

Timeframe	Studies, this research(%)	All Research%
pre-1990	5 (7.94)	18.7374
1990's	26 (41.27)	18.2507
2000's	28 (44.44)	29.6817
2010's	4 (6.35)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Allegra, CJ; Grem, JL; Trepel, JB; Yee, LK	1
Adamson, PC; Balis, FM; Blaney, SM; Cole, DE; Grem, J; Poplack, DG	1
De Clercq, E; Marquez, VE; Murase, J	1
Ahluwalia, GS; Cooney, DA; Dobyns, KA; Ford, H; Hao, Z; Hicks, L; Johns, DG; Rommel, ME; Tomaszewski, JE	1
Hartman, NR; Hegedus, L; Kelley, JA; Tomaszewski, JE; Zaharko, DS	1
Grem, JL; Harrison, SD; Hawkins, MJ; Plowman, J; Rubinstein, L	1
Bodenteich, M; Copp, RR; Lim, BB; Marquez, VE	1
Jordan, VC; Murphy, CS; Pink, JJ	1
Balis, FM; Blaney, SM; Hegedus, L; Heideman, RL; Kelley, JA; McCully, C; Murphy, RF; Poplack, DG	1
Cooney, DA; Johns, DG; Kang, GJ; Kelley, JA; Kim, HY; Marquez, VE; Moyer, JD	1
Driscoll, JS; Kaskar, B; Khan, MS; Lim, MI; Markovac, A; Marquez, VE; Plowman, J; Priest, MA; Treanor, SP	1
Cohen, MB; Glazer, RI; Hartman, KD; Knode, MC; Lim, MI; Marquez, VE	1
Malinowski, NM; Marquez, VE; Moyer, JD; Treanor, SP	1
Glazer, RI; Knode, MC; Lim, MI; Marquez, VE	1
Bouffard, DY; Momparler, LF; Momparler, RL	1
Allegra, CJ; Bastian, A; Chen, AP; Dahut, W; Ford, H; Hamilton, JM; Kelley, JA; Politi, PM; Setser, A; Xie, F	1
Bodlaender, JM; Slingerland, RJ; Van Gennip, AH; Van Kuilenburg, AB; Voûte, PA	2
Ahluwalia, G; Cooney, DA; Ford, H; Johns, DG; Zhang, H; Zhang, MH	1
Anderson, JO; Dobyns, KA; Driscoll, JS; Ford, H; Hao, Z; Johns, DG; Plowman, J; Rommel, ME; Stowe, E; Waud, WR	1
Agbaria, R; Johns, DG; Kelley, JA; Oldfield, EH; Oshiro, EM; Ram, Z; Viola, JJ; Walbridge, S	1
Driscoll, JS; Marquez, VE	1
Du, DL; Grieshaber, CK; Murphy, MJ; Volpe, DA	1
Agbaria, R; Allegra, CJ; Cooney, DA; Ford, H; Grem, JL; Johns, DG; Kelley, JA; Marquez, VE; Politi, P; Xie, F	1
Adamson, PC; Balis, FM; Blaney, SM; Cole, DE; Grem, JL; Poplack, DG	1
McClarty, G; Tipples, G; Wang, LL; Wylie, JL	1
Hatch, GM; McClarty, G	1
Ford, H; Hartman, NR; Hegedus, L; Kelley, JA	1
Agbaria, R; Jackman, J; Johns, DG; Kelley, JA; Oldfield, E; Ram, Z; Viola, JJ	1
Carman, GM; Gorman, JA; O'Brien, DJ; Ostrander, DB	1
Fritzer-Szekeres, M; Gharehbaghi, K; Jayaram, HN; Szekeres, T; Zhen, W	1
Elzinga, L; Leen, R; Muller, EJ; Van Gennip, AH; Van Kuilenburg, AB; Verschuur, AC; Voûte, PA	1
Leen, R; Meinsma, R; Van Gennip, AH; van Kuilenburg, AB; Verschuur, AC; Voute, PA	1
Fritzer-Szekeres, M; Gharehbaghi, K; Jayaram, HN; Pommier, YG; Szekeres, T; Yalowitz, JA	1
Parry, TE	1
Brinkman, J; Evers, LM; Leen, R; Van Gennip, AH; Van Kuilenburg, AB; Verschuur, AC; Vet, RJ; Voûte, PA	1
Bierau, J; Helleman, J; van Gennip, AH; van Kuilenburg, AB	1
Bierau, J; van Gennip, AH; van Kuilenburg, AB	1
Leen, R; van Gennip, AH; van Kuilenburg, AB; Verschuur, AC; Voûte, PA	1
Brinkman, J; van Gennip, AH; van Kuilenburg, AB; Verschuur, AC; Voûte, PA	1
Brinkman, J; Leen, R; Van Gennip, AH; Van Kuilenburg, AB; Verschuur, AC; Voûte, PA	1
Morrey, JD; Sidwell, RW; Smee, DF; Tseng, C	1
Bierau, J; Caron, HN; Leen, R; van Gennip, AH; van Kuilenburg, AB	1
Baker, RO; Chu, CK; Huggins, J; Jin, YH	1
Bierau, J; Caron, HN; Helleman, J; Leen, R; Van Gennip, AH; Van Kuilenburg, AB	1
Li, ML; Lin, YH; Simmonds, HA; Stollar, V	1
Collins, M; Graves, LM; Huang, M; Wang, Y	1
Leen, R; Van Gennip, AH; Van Kuilenburg, AB; Verschuur, AC	1
Bennink, R; de Bruin, K; Guchelaar, HJ; Leen, R; Pfaffendorf, M; Sand, K; Schimmel, K; Steinmetz, N; van den Hoff, M; van Kuilenburg, A; Vanderheyden, JL; Verschuur, A	1
Bierau, J; Caron, HN; Leen, R; Meinsma, R; van Gennip, AH; van Kuilenburg, AB	1
Guchelaar, HJ; Schimmel, K; van Kan, E	1
Falkenburg, JH; Guchelaar, HJ; Nijmeijer, BA; Schimmel, KJ; van Schie, ML	1
van Bree, C; van Kuilenburg, AB	1
Gelderblom, H; Guchelaar, HJ; Schimmel, KJ	1
Bemelman, FJ; Nikolaeva, N; ten Berge, IJ; van Lier, RA; Verschuur, A; Yong, SL	1
Leen, R; Medema, J; Rodermond, H; van Bree, C; van Kuilenburg, A	1
Guchelaar, HJ; Kulik, W; Leen, R; Schimmel, K; van Kuilenburg, A; van Lenthe, H; Verschuur, A	1
Gordon, YJ; Romanowski, EG	1
Barten-Van Rijbroek, AD; Kal, HB; Leen, R; Rodermond, HM; Van Bree, C; Van Kuilenburg, AB	1
Huang, M; Lewicki, P; Mitchell, BS; Whang, P	1
Chen, SY; Cui, XB; Tang, R; Wang, JN	1
Sata, M; Tanaka, K	1
Chen, SY; Tang, R; Zhang, G	1

Reviews

1 review(s) available for cytidine and cyclopentenyl cytosine

Article	Year
Cyclopentenyl cytosine (CPEC): an overview of its in vitro and in vivo activity. Current cancer drug targets, 2007, Volume: 7, Issue:5 Topics: Animals; Antineoplastic Agents; Carbon-Nitrogen Ligases; Cell Line, Tumor; Cytidine; Enzyme Inhibitors; Humans	2007

Trials

1 trial(s) available for cytidine and cyclopentenyl cytosine

Article	Year
Phase I clinical trial of continuous infusion cyclopentenyl cytosine. Cancer chemotherapy and pharmacology, 1995, Volume: 36, Issue:6 Topics: Adult; Aged; Antineoplastic Agents; Bone Marrow; Carbon-Nitrogen Ligases; Chromatography, High Pressure Liquid; Cytidine; Female; Humans; Hypotension; Infusions, Intravenous; Ligases; Male; Metabolic Clearance Rate; Middle Aged; Neoplasms	1995

Other Studies

61 other study(ies) available for cytidine and cyclopentenyl cytosine

Article	Year
Metabolism and RNA incorporation of cyclopentenyl cytosine in human colorectal cancer cells. Biochemical pharmacology, 1992, Apr-01, Volume: 43, Issue:7 Topics: Adenosine; Cell Survival; Colorectal Neoplasms; Cytidine; DNA, Neoplasm; Dose-Response Relationship, Drug; Humans; Leukemia; Methanol; Ribonucleotides; RNA, Neoplasm; Time Factors; Tumor Cells, Cultured	1992
Modulation of the cytotoxic effect of cyclopentenylcytosine by its primary metabolite, cyclopentenyluridine. Cancer research, 1992, Jun-15, Volume: 52, Issue:12 Topics: Cell Survival; Cytidine; Dose-Response Relationship, Drug; Drug Administration Schedule; Humans; Leukemia; Tumor Cells, Cultured; Uracil	1992
Broad-spectrum antiviral and cytocidal activity of cyclopentenylcytosine, a carbocyclic nucleoside targeted at CTP synthetase. Biochemical pharmacology, 1991, Jun-15, Volume: 41, Issue:12 Topics: Adenosine; Amides; Antiviral Agents; Azauridine; Carbon-Nitrogen Ligases; Cell Division; Cytarabine; Cytidine; Deoxycytidine; Drug Synergism; Fluorouracil; HeLa Cells; Humans; Ligases; Nucleosides; Pyrazoles; Ribavirin; Ribonucleosides; Ribose; Thymidine; Tumor Cells, Cultured; Uracil; Virus Replication; Viruses	1991
Cellular pharmacology of cyclopentenyl cytosine in Molt-4 lymphoblasts. Cancer research, 1991, Jul-15, Volume: 51, Issue:14 Topics: Antineoplastic Agents; Cell Line; Cytidine; Cytidine Triphosphate; DNA; Humans; Lymphocytes; Protein Biosynthesis; RNA	1991
Cyclopentenyl cytosine: interspecies predictions based on rodent plasma and urine kinetics. Investigational new drugs, 1991, Volume: 9, Issue:1 Topics: Animals; Antineoplastic Agents; Computer Simulation; Cytidine; Dogs; Drug Administration Schedule; Injections, Intravenous; Mice; Models, Biological; Rats; Species Specificity	1991
Modulation of cytosine arabinoside toxicity by 3-deazauridine in a murine leukemia model. Leukemia research, 1991, Volume: 15, Issue:4 Topics: 3-Deazauridine; Animals; Antineoplastic Combined Chemotherapy Protocols; Cytarabine; Cytidine; Drug Resistance; Drug Synergism; Female; Leukemia L1210; Male; Mice; Mice, Inbred Strains; Remission Induction; Survival Rate	1991
Synthesis and biological activity of novel carbocyclic nucleosides. Nucleic acids symposium series, 1990, Issue:22 Topics: Adenosine; Antibiotics, Antineoplastic; Antineoplastic Agents; Cytidine; Molecular Structure; Nucleosides	1990
Characterization of a receptor-negative, hormone-nonresponsive clone derived from a T47D human breast cancer cell line kept under estrogen-free conditions. Cancer research, 1990, Nov-15, Volume: 50, Issue:22 Topics: Blotting, Northern; Breast Neoplasms; Cell Division; Clone Cells; Cytidine; DNA Fingerprinting; DNA, Neoplasm; ErbB Receptors; Estradiol; Gene Expression; Humans; In Vitro Techniques; Polyunsaturated Alkamides; Receptors, Estrogen; Receptors, Progesterone; RNA, Messenger; Tamoxifen; Transforming Growth Factor alpha; Transforming Growth Factor beta; Tumor Cells, Cultured	1990
Pharmacokinetics and metabolism of cyclopentenyl cytosine in nonhuman primates. Cancer research, 1990, Dec-15, Volume: 50, Issue:24 Topics: Animals; Cytidine; Dogs; Female; Infusions, Intravenous; Injections, Intravenous; Macaca mulatta; Male; Metabolic Clearance Rate; Mice; Molecular Structure; Rats; Species Specificity	1990
Cyclopentenylcytosine triphosphate. Formation and inhibition of CTP synthetase. The Journal of biological chemistry, 1989, Jan-15, Volume: 264, Issue:2 Topics: Animals; Carbon-Nitrogen Ligases; Cytidine; Cytidine Triphosphate; Cytosine Nucleotides; Kinetics; Leukemia L1210; Leukemia P388; Ligases; Mass Spectrometry; Mice; Phosphorylation	1989
Cyclopentenylcytosine. A carbocyclic nucleoside with antitumor and antiviral properties. Journal of medicinal chemistry, 1988, Volume: 31, Issue:9 Topics: 3-Deazauridine; Animals; Antineoplastic Agents; Antiviral Agents; Chemical Phenomena; Chemistry; Cytidine; DNA Viruses; Humans; Leukemia L1210; Leukemia P388; Lung Neoplasms; Mammary Neoplasms, Experimental; Melanoma; Mice; Mice, Nude; Neoplasm Transplantation; Neoplasms, Experimental; Orthomyxoviridae; RNA Viruses; Sarcoma, Experimental; Viruses	1988
Induction of differentiation in the human promyelocytic leukemia cell line HL-60 by the cyclopentenyl analogue of cytidine. Biochemical pharmacology, 1986, Jun-01, Volume: 35, Issue:11 Topics: Cell Differentiation; Cell Division; Cell Line; Cytidine; Humans; Kinetics; Leukemia, Myeloid, Acute; Nucleic Acid Hybridization; Oncogenes; Ribonucleosides; Ribonucleotides; RNA, Messenger; Structure-Activity Relationship	1986
Antitumor activity and biochemical effects of cyclopentenyl cytosine in mice. Cancer research, 1986, Volume: 46, Issue:7 Topics: Animals; Cells, Cultured; Cytidine; Cytosine Nucleotides; Dose-Response Relationship, Drug; Leukemia L1210; Leukemia P388; Melanoma; Mice; Neoplasms, Experimental	1986
Cyclopentenyl cytidine analogue. An inhibitor of cytidine triphosphate synthesis in human colon carcinoma cells. Biochemical pharmacology, 1985, Jul-15, Volume: 34, Issue:14 Topics: Antineoplastic Agents; Cell Line; Cell Survival; Colonic Neoplasms; Cytidine; Cytidine Triphosphate; Cytosine Nucleotides; DNA, Neoplasm; Humans; RNA, Neoplasm; Uridine	1985
Enhancement of the antileukemic activity of 5-aza-2'-deoxycytidine by cyclopentenyl cytosine in HL-60 leukemic cells. Anti-cancer drugs, 1994, Volume: 5, Issue:2 Topics: Antineoplastic Agents; Azacitidine; Cell Division; Cytidine; Cytidine Deaminase; Decitabine; Deoxycytosine Nucleotides; DNA, Neoplasm; Drug Synergism; Humans; Leukemia, Experimental; Tumor Cells, Cultured	1994
Cyclopentenyl cytosine and neuroblastoma SK-N-BE(2)-C cell line cells. European journal of cancer (Oxford, England : 1990), 1995, Volume: 31A, Issue:4 Topics: Antineoplastic Agents; Cell Cycle; Cell Survival; Chromatography, High Pressure Liquid; Cytidine; Drug Screening Assays, Antitumor; Humans; Neuroblastoma; Tumor Cells, Cultured	1995
The effect of cyclopentenyl cytosine on human SK-N-BE(2)-C neuroblastoma cells. Biochemical pharmacology, 1995, Jul-17, Volume: 50, Issue:2 Topics: Antineoplastic Agents; Apoptosis; Cell Survival; Cytidine; DNA, Neoplasm; Humans; Neuroblastoma; Tumor Cells, Cultured	1995
Resistance to cyclopentenylcytosine in murine leukemia L1210 cells. Cancer research, 1993, Dec-01, Volume: 53, Issue:23 Topics: Animals; Antineoplastic Agents; Carbon-Nitrogen Ligases; Cytidine; Cytidine Triphosphate; Deamination; Drug Resistance; Leukemia L1210; Ligases; Mice; Phosphorylation; RNA; Tumor Cells, Cultured	1993
Reversal by cytidine of cyclopentenyl cytosine-induced toxicity in mice without compromise of antitumor activity. Biochemical pharmacology, 1995, Jan-18, Volume: 49, Issue:2 Topics: Animals; Antineoplastic Agents; Cytidine; Cytidine Triphosphate; Drug Interactions; Leukemia L1210; Male; Mice; Survival Analysis; Tumor Cells, Cultured	1995
In situ cyclopentenyl cytosine infusion for the treatment of experimental brain tumors. Cancer research, 1995, Mar-15, Volume: 55, Issue:6 Topics: Animals; Antineoplastic Agents; Biotransformation; Brain Neoplasms; Cytidine; Cytidine Triphosphate; Drug Stability; Gliosarcoma; Rats; Rats, Inbred F344; Tissue Distribution	1995
The design and synthesis of a new anticancer drug based on a natural product lead compound: from neplanocin A to cyclopentenyl cytosine (CPE-C). Stem cells (Dayton, Ohio), 1994, Volume: 12, Issue:1 Topics: Adenosine; Antiviral Agents; Cytidine; Drug Design; Humans; In Vitro Techniques	1994
In vitro characterization of the myelotoxicity of cyclopentenyl cytosine. Cancer chemotherapy and pharmacology, 1994, Volume: 34, Issue:2 Topics: Animals; Antineoplastic Agents; Bone Marrow; Bone Marrow Cells; Carmustine; Cell Count; Clone Cells; Colony-Forming Units Assay; Cytidine; Dose-Response Relationship, Drug; Hematopoietic Stem Cells; Humans; Mice; Time Factors	1994
Measurement of cyclopentenyl cytosine 5'-triphosphate in vitro and in vivo by multidimensional high-performance liquid chromatography. Analytical biochemistry, 1993, Aug-15, Volume: 213, Issue:1 Topics: Animals; Antineoplastic Agents; Cattle; Chromatography, High Pressure Liquid; Cytidine; Cytidine Triphosphate; Humans; Intracellular Fluid; Leukocytes, Mononuclear; Phosphates; Reference Standards; Reproducibility of Results; T-Lymphocytes	1993
Mechanism of resistance to cyclopentenyl cytosine (CPE-C) in Molt-4 lymphoblasts. Biochemical pharmacology, 1993, Apr-06, Volume: 45, Issue:7 Topics: Antineoplastic Agents; Cell Survival; Cytidine; Cytidine Deaminase; Dose-Response Relationship, Drug; Drug Resistance; Humans; Lymphocytes; Middle Aged; Ribonucleotides; Tumor Cells, Cultured; Uridine Kinase	1993
A single point mutation in CTP synthetase of Chlamydia trachomatis confers resistance to cyclopentenyl cytosine. The Journal of biological chemistry, 1996, Jun-28, Volume: 271, Issue:26 Topics: Amino Acid Sequence; Antimetabolites, Antineoplastic; Carbon-Nitrogen Ligases; Chlamydia trachomatis; Cytidine; DNA, Bacterial; Drug Resistance, Microbial; Feedback; Fluorouracil; Ligases; Molecular Sequence Data; Point Mutation; Structure-Activity Relationship	1996
Regulation of cardiolipin biosynthesis in H9c2 cardiac myoblasts by cytidine 5'-triphosphate. The Journal of biological chemistry, 1996, Oct-18, Volume: 271, Issue:42 Topics: Animals; Antineoplastic Agents; Cardiolipins; Cell Line; Chromatography, Thin Layer; Cytidine; Cytidine Diphosphate Diglycerides; Cytidine Triphosphate; DNA Replication; Linoleic Acid; Linoleic Acids; Myocardium; Nucleotidyltransferases; Phosphatidic Acids; Phosphatidylcholines; Phosphatidylethanolamines; Phosphatidylglycerols; Phosphatidylinositols; Rats; RNA; Triglycerides	1996
Reversed-phase high-performance liquid chromatographic determination of the new antitumor agent cyclopentenyl cytosine in biological fluids. Journal of chromatography. B, Biomedical sciences and applications, 1997, Apr-25, Volume: 692, Issue:1 Topics: Animals; Antineoplastic Agents; Blood Proteins; Chromatography, High Pressure Liquid; Cytidine; Dogs; Drug Stability; Female; Humans; Hydrogen-Ion Concentration; Hydrolysis; Male; Protein Binding; Rats; Rats, Sprague-Dawley; Spectrophotometry, Ultraviolet	1997
Antiproliferative effects of cyclopentenyl cytosine (NSC 375575) in human glioblastoma cells. Oncology research, 1997, Volume: 9, Issue:3 Topics: Adult; Antimetabolites, Antineoplastic; Cell Division; Cytidine; Cytidine Triphosphate; Dose-Response Relationship, Drug; Glioblastoma; Growth Inhibitors; Humans; Male; Nucleotides; Tumor Cells, Cultured	1997
Effect of CTP synthetase regulation by CTP on phospholipid synthesis in Saccharomyces cerevisiae. The Journal of biological chemistry, 1998, Jul-24, Volume: 273, Issue:30 Topics: Amino Acid Substitution; Antineoplastic Agents; Carbon-Nitrogen Ligases; Cytidine; Cytidine Triphosphate; Glutamine; Lysine; Mutagenesis, Site-Directed; Phospholipids; Pyrimidines; Saccharomyces cerevisiae	1998
Studies on the antitumor activity and biochemical actions of cyclopentenyl cytosine against human colon carcinoma HT-29 in vitro and in vivo. Life sciences, 1999, Volume: 64, Issue:2 Topics: Adenosine Triphosphate; Animals; Antineoplastic Agents; Cell Survival; Chromatography, High Pressure Liquid; Colonic Neoplasms; Cytidine; Cytidine Triphosphate; Dose-Response Relationship, Drug; Guanosine Triphosphate; HT29 Cells; Humans; Mice; Mice, Nude; Time Factors; Uridine Triphosphate	1999
Cyclopentenyl cytosine inhibits cytidine triphosphate synthetase in paediatric acute non-lymphocytic leukaemia: a promising target for chemotherapy. European journal of cancer (Oxford, England : 1990), 2000, Volume: 36, Issue:5 Topics: Adolescent; Antineoplastic Agents; Carbon-Nitrogen Ligases; Child; Child, Preschool; Cytidine; Female; Humans; Leukemia, Myeloid, Acute; Male; Neoplasm Proteins; Tumor Cells, Cultured	2000
In vitro inhibition of cytidine triphosphate synthetase activity by cyclopentenyl cytosine in paediatric acute lymphocytic leukaemia. British journal of haematology, 2000, Volume: 110, Issue:1 Topics: Adult; Antigens, CD34; Carbon-Nitrogen Ligases; Case-Control Studies; Cells, Cultured; Child; Child, Preschool; Cytidine; Dose-Response Relationship, Drug; Enzyme Inhibitors; Female; Hematopoietic Stem Cells; Humans; Lymphocytes; Male; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Ribonucleotides; RNA, Messenger; Statistics, Nonparametric	2000
Sensitizing human colon carcinoma HT-29 cells to cisplatin by cyclopentenylcytosine, in vitro and in vivo. Life sciences, 2000, Nov-24, Volume: 68, Issue:1 Topics: Animals; Antineoplastic Agents; Cisplatin; Cytidine; Drug Synergism; HT29 Cells; Humans; Mice; Neoplasm Transplantation	2000
Comments on: cylopentenyl cytosine inhibits cytidine triphosphate synthetase in paediatric acute non-lymphocytic leukaemia: a promising target for chemotherapy. A.C. Verschuur et al. Eur J Cancer 2000, 36, 627-635. European journal of cancer (Oxford, England : 1990), 2001, Volume: 37, Issue:2 Topics: Carbon-Nitrogen Ligases; Child; Cytidine; Humans; Leukemia, Myeloid, Acute; Neoplasm Proteins	2001
Cyclopentenyl cytosine induces apoptosis and increases cytarabine-induced apoptosis in a T-lymphoblastic leukemic cell-line. Leukemia research, 2001, Volume: 25, Issue:10 Topics: Annexin A5; Antimetabolites, Antineoplastic; Antineoplastic Agents; Apoptosis; Cell Division; Cytarabine; Cytidine; Dose-Response Relationship, Drug; Drug Synergism; Humans; Leukemia, T-Cell; Necrosis; Tumor Cells, Cultured	2001
The cytostatic- and differentiation-inducing effects of cyclopentenyl cytosine on neuroblastoma cell lines. Biochemical pharmacology, 2001, Oct-15, Volume: 62, Issue:8 Topics: Antineoplastic Agents; Carbon-Nitrogen Ligases; Cell Cycle; Cell Differentiation; Cell Division; Cytidine; Cytidine Triphosphate; Humans; Neuroblastoma; Tumor Cells, Cultured	2001
Recovery of SK-N-BE(2)c cells from treatment with cyclopentenyl cytosine. Advances in experimental medicine and biology, 2000, Volume: 486 Topics: Antineoplastic Agents; Cytidine; Cytidine Triphosphate; Humans; Neuroblastoma; Tumor Cells, Cultured	2000
Cyclopentenyl cytosine increases the phosphorylation and incorporation into dna of arabinofu-ranosyl cytosine in a myeloid leukemic cell-line. Advances in experimental medicine and biology, 2000, Volume: 486 Topics: Antimetabolites, Antineoplastic; Antineoplastic Agents; Carbon-Nitrogen Ligases; Cytarabine; Cytidine; Cytidine Diphosphate; Cytidine Monophosphate; Deoxycytosine Nucleotides; DNA; Dose-Response Relationship, Drug; Enzyme Inhibitors; HL-60 Cells; Humans; Leukemia, Myeloid; Phosphorylation	2000
Cyclopentenyl cytosine induces apoptosis and secondary necrosis in a T-lymphoblastic leukemic cell-line. Advances in experimental medicine and biology, 2000, Volume: 486 Topics: Amino Acid Chloromethyl Ketones; Antineoplastic Agents; Apoptosis; Carbon-Nitrogen Ligases; Caspase Inhibitors; Cell Line; Cysteine Proteinase Inhibitors; Cytidine; Enzyme Inhibitors; Humans; Leukemia-Lymphoma, Adult T-Cell; Time Factors	2000
Cyclopentenyl cytosine increases the phosphorylation and incorporation into DNA of 1-beta-D-arabinofuranosyl cytosine in a human T-lymphoblastic cell line. International journal of cancer, 2002, Apr-01, Volume: 98, Issue:4 Topics: Antineoplastic Agents; Apoptosis; Cell Division; Cytarabine; Cytidine; Cytidine Triphosphate; Deoxycytosine Nucleotides; DNA; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm; Humans; Phosphorylation; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Time Factors; Tumor Cells, Cultured	2002
Identification of active antiviral compounds against a New York isolate of West Nile virus. Antiviral research, 2002, Volume: 55, Issue:1 Topics: Amides; Animals; Antiviral Agents; Azauridine; Chlorocebus aethiops; Cytidine; Cytopathogenic Effect, Viral; Enzyme Inhibitors; Inhibitory Concentration 50; Mycophenolic Acid; New York; Pyrazoles; Ribavirin; Ribonucleosides; Ribose; Thiouridine; Vero Cells; Virus Replication; West Nile virus	2002
Retinoic acid reduces the cytotoxicity of cyclopentenyl cytosine in neuroblastoma cells. FEBS letters, 2002, Sep-11, Volume: 527, Issue:1-3 Topics: Antineoplastic Agents; Apoptosis; Cell Differentiation; Cell Division; Cytidine; Cytidine Triphosphate; Drug Interactions; Humans; Neuroblastoma; Polyphosphates; Tretinoin; Tumor Cells, Cultured	2002
Antiviral activity of cyclopentenyl nucleosides against orthopox viruses (Smallpox, monkeypox and cowpox). Bioorganic & medicinal chemistry letters, 2003, Jan-06, Volume: 13, Issue:1 Topics: Adenosine; Animals; Antiviral Agents; Cell Line; Cell Survival; Cowpox virus; Cytidine; Monkeypox virus; Nucleosides; Orthopoxvirus; Structure-Activity Relationship; Variola virus	2003
Cyclopentenyl cytosine primes SK-N-BE(2)c neuroblastoma cells for cytarabine toxicity. International journal of cancer, 2003, Jan-20, Volume: 103, Issue:3 Topics: Antimetabolites, Antineoplastic; Apoptosis; Carbon-Nitrogen Ligases; Cell Cycle; Cell Division; Cytarabine; Cytidine; DNA, Neoplasm; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm; Drug Synergism; Enzyme Inhibitors; Humans; Neuroblastoma; Phosphorylation; Tumor Cells, Cultured	2003
A mutant of Sindbis virus which is able to replicate in cells with reduced CTP makes a replicase/transcriptase with a decreased Km for CTP. Journal of virology, 2004, Volume: 78, Issue:18 Topics: Aedes; Amides; Animals; Cell Line; Cytidine; Cytidine Triphosphate; Drug Resistance, Viral; Genes, Viral; Kinetics; Mutation; Pyrazoles; Ribonucleosides; Ribose; RNA-Dependent RNA Polymerase; RNA-Directed DNA Polymerase; Sindbis Virus; Virus Replication	2004
CPEC induces erythroid differentiation of human myeloid leukemia K562 cells through CTP depletion and p38 MAP kinase. Leukemia, 2004, Volume: 18, Issue:11 Topics: Affinity Labels; Carbon-Nitrogen Ligases; Cell Differentiation; Cytidine; Cytidine Triphosphate; Dipyridamole; Enzyme Inhibitors; Equilibrative Nucleoside Transporter 1; Erythroid Precursor Cells; Humans; Isoxazoles; K562 Cells; Leflunomide; Leukemia, Myeloid; p38 Mitogen-Activated Protein Kinases; Phosphodiesterase Inhibitors; Pyrimidines; RNA, Small Interfering; S Phase; Thioinosine	2004
Increased cytotoxicity of 2',2'-difluoro-2'-deoxycytidine in human leukemic cell-lines after a preincubation with cyclopentenyl cytosine. Nucleosides, nucleotides & nucleic acids, 2004, Volume: 23, Issue:8-9 Topics: Antimetabolites, Antineoplastic; Antineoplastic Agents; Apoptosis; Carbon-Nitrogen Ligases; Cell Line, Tumor; Cell Separation; Clinical Trials as Topic; Cytidine; Deoxycytidine; DNA; Dose-Response Relationship, Drug; Flow Cytometry; Gemcitabine; HL-60 Cells; Humans; Necrosis; Neoplasms; Time Factors	2004
Absence of cardiotoxicity of the experimental cytotoxic drug cyclopentenyl cytosine (CPEC) in rats. Archives of toxicology, 2005, Volume: 79, Issue:5 Topics: Animals; Annexin A5; Antineoplastic Agents; Apoptosis; Cardiomyopathies; Cytidine; Disease Models, Animal; Heart; Heart Atria; In Situ Nick-End Labeling; Male; Myocardial Contraction; Myocardium; Organotechnetium Compounds; Rats; Rats, Wistar; Tomography, Emission-Computed, Single-Photon; Troponin T	2005
Cyclopentenyl cytosine-induced activation of deoxycytidine kinase increases gemcitabine anabolism and cytotoxicity in neuroblastoma. Cancer chemotherapy and pharmacology, 2006, Volume: 57, Issue:1 Topics: Antineoplastic Agents; Cell Differentiation; Cell Line, Tumor; Cell Survival; Cytidine; Deoxycytidine; Deoxycytidine Kinase; Dose-Response Relationship, Drug; Drug Synergism; Enzyme Activation; Gemcitabine; Humans; Immunoblotting; N-Myc Proto-Oncogene Protein; Neuroblastoma; Nuclear Proteins; Oncogene Proteins	2006
Formulation, quality control and shelf life of the experimental cytostatic drug cyclopentenyl cytosine. Drug development and industrial pharmacy, 2006, Volume: 32, Issue:4 Topics: Antineoplastic Agents; Chemistry, Pharmaceutical; Cytidine; Drug Stability; Drug Storage; Drugs, Investigational; Molecular Structure; Quality Control	2006
Limited antitumor-effect associated with toxicity of the experimental cytotoxic drug cyclopentenyl cytosine in NOD/scid mice with acute lymphoblastic leukemia. Leukemia research, 2007, Volume: 31, Issue:11 Topics: Animals; Antineoplastic Agents; Cytidine; Humans; Karyotyping; Mice; Mice, Inbred BALB C; Mice, Inbred NOD; Mice, SCID; Precursor Cell Lymphoblastic Leukemia-Lymphoma	2007
Will cyclopentenyl cytosine (CPEC) ever have a future in the clinic? Leukemia research, 2008, Volume: 32, Issue:2 Topics: Animals; Antineoplastic Agents; Clinical Trials as Topic; Cytidine; Humans; Medical Oncology; Precursor Cell Lymphoblastic Leukemia-Lymphoma	2008
The pyrimidin analogue cyclopentenyl cytosine induces alloantigen-specific non-responsiveness of human T lymphocytes. Clinical and experimental immunology, 2008, Volume: 151, Issue:2 Topics: Animals; Apoptosis; CD4-Positive T-Lymphocytes; CD8-Positive T-Lymphocytes; Cell Proliferation; Cells, Cultured; Clonal Anergy; Cytidine; Cytotoxicity, Immunologic; Dose-Response Relationship, Immunologic; Enzyme Inhibitors; Graft Survival; Humans; Immunosuppressive Agents; Isoantigens; Lymphocyte Activation; Mice; Mice, Inbred Strains; Skin Transplantation; T-Lymphocyte Subsets	2008
Cyclopentenyl cytosine increases gemcitabine radiosensitisation in human pancreatic cancer cells. British journal of cancer, 2008, Apr-08, Volume: 98, Issue:7 Topics: Apoptosis; Cell Line, Tumor; Cell Survival; Cytidine; Cytidine Triphosphate; Deoxycytidine; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Drug Synergism; Gemcitabine; Humans; Lung Neoplasms; Pancreatic Neoplasms; Radiation Tolerance; Radiation-Sensitizing Agents	2008
Quantitative analysis of the experimental cytotoxic drug cyclopentenyl cytosine and its metabolite in plasma with HPLC tandem mass spectrometry. Biomedical chromatography : BMC, 2008, Volume: 22, Issue:12 Topics: Chromatography, High Pressure Liquid; Cytidine; Humans; Molecular Structure; Reproducibility of Results; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry; Uracil	2008
Update on antiviral treatment of adenoviral ocular infections. American journal of ophthalmology, 2008, Volume: 146, Issue:5 Topics: Adenoviridae Infections; Animals; Antiviral Agents; Cytidine; Eye Infections; Humans; Immunoglobulins, Intravenous; Zalcitabine	2008
Cyclopentenyl cytosine has biological and anti-tumour activity, but does not enhance the efficacy of gemcitabine and radiation in two animal tumour models. International journal of oncology, 2009, Volume: 34, Issue:3 Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Cell Line, Tumor; Combined Modality Therapy; Cytidine; Cytidine Triphosphate; Deoxycytidine; Disease Models, Animal; Drug Synergism; Female; Gemcitabine; Humans; Lung Neoplasms; Mice; Mice, Nude; Middle Aged; Pancreatic Neoplasms; Rats; Rats, Inbred BN	2009
Cyclopentenyl cytosine induces senescence in breast cancer cells through the nucleolar stress response and activation of p53. Molecular pharmacology, 2011, Volume: 80, Issue:1 Topics: Antineoplastic Agents; Breast Neoplasms; Cell Line, Tumor; Cell Nucleolus; Cellular Senescence; Cyclin-Dependent Kinase Inhibitor p21; Cytidine; Cytidine Triphosphate; Female; Gene Silencing; Genes, p53; Histones; Humans; Immunohistochemistry; RNA, Small Interfering	2011
CTP synthase 1, a smooth muscle-sensitive therapeutic target for effective vascular repair. Arteriosclerosis, thrombosis, and vascular biology, 2013, Volume: 33, Issue:10 Topics: Angioplasty, Balloon; Animals; Carbon-Nitrogen Ligases; Carotid Artery Injuries; Cell Cycle; Cell Proliferation; Cells, Cultured; Cytidine; Disease Models, Animal; Dose-Response Relationship, Drug; Endothelial Cells; Enzyme Inhibitors; Genetic Therapy; Male; Mice; Mice, Inbred C57BL; Molecular Targeted Therapy; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Neointima; NM23 Nucleoside Diphosphate Kinases; Rats; Rats, Sprague-Dawley; RNA Interference; Time Factors; Vascular System Injuries	2013
Blockade of cytidine triphosphate synthase regulates smooth muscle cell and endothelial cell proliferation differentially. Arteriosclerosis, thrombosis, and vascular biology, 2013, Volume: 33, Issue:10 Topics: Animals; Carbon-Nitrogen Ligases; Carotid Artery Injuries; Cytidine; Enzyme Inhibitors; Genetic Therapy; Male; Molecular Targeted Therapy; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Vascular System Injuries	2013
Smooth Muscle Cell Proangiogenic Phenotype Induced by Cyclopentenyl Cytosine Promotes Endothelial Cell Proliferation and Migration. The Journal of biological chemistry, 2016, Dec-23, Volume: 291, Issue:52 Topics: Animals; Antineoplastic Agents; Aorta; Cell Movement; Cell Proliferation; Cells, Cultured; Coculture Techniques; Culture Media, Conditioned; Cytidine; Endothelium, Vascular; Male; Myocytes, Smooth Muscle; Neointima; Neovascularization, Physiologic; Phenotype; Rats; Rats, Sprague-Dawley; Signal Transduction	2016