cytidine has been researched along with azacitidine in 104 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 51 (49.04) | 18.7374 |
| 1990's | 7 (6.73) | 18.2507 |
| 2000's | 21 (20.19) | 29.6817 |
| 2010's | 23 (22.12) | 24.3611 |
| 2020's | 2 (1.92) | 2.80 |
| Authors | Studies |
|---|---|
| Karon, M; Lee, T; Monparler, RL | 1 |
| Anderson, JE; Giblett, ER; Teng, YS | 1 |
| Karon, MR; Lee, TT | 1 |
| Lee, TT; Momparier, RL | 1 |
| Chabner, BA; Drake, JC; Stoller, RG | 1 |
| Presant, CA; Valeriote, F; Vietti, TJ | 1 |
| Goodman, J; Momparler, RL | 1 |
| Abbasi, MM; Beisler, JA; Voytek, P; Wolpert-DeFilippes, MK | 1 |
| Abraham, D; Behrens, M; Plagemann, PG | 1 |
| Lu, LJ; Randerath, K | 1 |
| Anderson, EP; Liacouras, AS | 1 |
| Cihák, A; Veselý, J | 3 |
| Laliberté, J; Marquez, VE; Momparler, RL | 1 |
| Call, KM; Thilly, WG | 1 |
| Allegra, CJ; Grem, JL | 1 |
| Veselý, J | 1 |
| Ahluwalia, GS; Arnold, ST; Balzarini, J; Cohen, MB; Cooney, DA; Dalal, M; Johns, DG; Kang, GJ; McMahon, JB; Wilson, YA | 1 |
| Amacher, DE; Turner, GN | 1 |
| Bhagwat, AS; Roberts, RJ | 1 |
| Frahm, J; Hoshino, J; Kröger, H | 1 |
| Bernheim, J; Buyssens, N; Cortvrindt, R; Roobol, K | 1 |
| el Halawani, ME; Fehrer, SC; Guise, KS; Silsby, JL | 1 |
| Cihák, A; Filippovich, IV; Greger, J; Veselý, J | 1 |
| Kittler, L | 1 |
| Doskocil, J | 1 |
| Benedict, WF; Karon, M | 1 |
| Burchenal, JH; Carter, SK | 1 |
| Heby, O; Russell, DH | 1 |
| Adams, RL; Imrie, RC; Zain, BS | 1 |
| Fucík, V; Jurovcík, M; Sormová, Z; Zadrazil, S | 1 |
| Broucek, J; Cihák, A | 1 |
| Dulmadge, EA; Lloyd, HH; Wilkoff, LJ | 1 |
| Hahn, RG; Moertel, CG; Reitemeier, RJ; Schutt, AJ | 1 |
| Cihák, A; Seifertová, M; Sorm, F; Vesselý, J | 1 |
| Cihák, A; Seifertová, M; Sorm, F; Veselý, J | 1 |
| Cihák, A; Inoue, H; Pitot, HC; Veselý, J | 1 |
| Cihák, A; Seifertová, M; Veselý, J | 1 |
| Bellet, RE; Custer, RP; Engstrom, PF; Mastrangelo, MJ | 1 |
| Finklestein, JZ; Karon, M; Leimbrock, S; Nesbit, ME; Sieger, L; Swaney, JJ | 1 |
| Cihak, A; Lamar, C; Pitot, HC | 1 |
| Chabner, BA; Drake, JC; Johns, DG | 1 |
| Pitot, HC; Weiss, JW | 1 |
| Karon, M; Lee, T; Momparler, RL | 1 |
| Grundmann, E; Löbbecke, EA; Voigt, WH | 1 |
| Jones, PA; Taylor, SM | 2 |
| Chiang, GH; Lu, LJ; Randerath, K | 1 |
| Cadman, E; Grant, S; Jakubowski, A; Rauscher, F | 1 |
| Niwa, O; Sugahara, T | 1 |
| Harris, JS; Lu, LJ; Randerath, K; Tseng, WC | 1 |
| Schmidt, SY | 1 |
| Constantinides, PA; Jones, PA; Taylor, SM | 1 |
| Nohmi, T; Ohta, T; Watanabe, M | 1 |
| Novotný, L; Pískala, A; Vachálková, A | 1 |
| Bouffard, DY; Momparler, LF; Momparler, RL | 1 |
| Doi, K; Kajikawa, S; Nakayama, H; Shinozuka, J; Su, WP | 1 |
| Ohta, T; Watanabe-Akanuma, M; Yamagata, H | 1 |
| Berru, M; Ronai, D; Shulman, MJ | 1 |
| Leone, G; Lübbert, M; Teofili, L; Voso, MT | 1 |
| Cappellacci, L; Montgomery, JA; Secrist, JA; Tiwari, KN | 1 |
| Cheng, JC; Gonzales, FA; Hu, YG; Jones, PA; Liang, G; Marquez, VE; Weisenberger, DJ; Xu, GL | 1 |
| Alleman, WG; Aprelikova, ON; Chandramouli, GV; Linehan, WM; Mendoza, A; Rodgers, C; Rogers, C; Sopko, NA; Tabios, RL; Torres-Cabala, C; Vasselli, JR | 1 |
| Cheng, JC; Jones, PA; Yoo, CB | 1 |
| Bernstein, ML; Lemaire, M; Marquez, VE; Momparler, LF; Momparler, RL | 1 |
| Cherry, JC; Farrar, WL; Fox, SD; Hodge, DR; Hurt, EM; Kelley, JA; Munroe, DJ; Peng, B | 1 |
| Balch, C; Craft, T; Huang, TH; Nephew, KP; Skalnik, DG; Yan, P; Young, S | 1 |
| Chuang, JC; Jones, PA; Kwan, JM; Li, TW; Liang, G; Yang, AS; Yoo, CB | 1 |
| Baylin, SB; Eguchi, S; Esteller, M; Fraga, MF; Fuks, F; Griffioen, AW; Hellebrekers, DM; Hoebers, NT; Jair, KW; van Engeland, M; Viré, E | 1 |
| Brueckner, B; Lyko, F; Musch, T; Stopper, H; Stresemann, C | 1 |
| Chen, Y; Costa, E; Grayson, DR; Kundakovic, M | 1 |
| Christoph, F; Kempkensteffen, C; Köllermann, J; Krause, H; Miller, K; Schostak, M; Schrader, M; Weikert, S | 1 |
| Berger, C; Bernasconi, M; Nadal, D; Rao, SP; Rechsteiner, MP; Sigrist, JA | 1 |
| Bernstein, ML; Lemaire, M; Momparler, LF; Momparler, RL; Raynal, NJ | 1 |
| Issa, JP; Oki, Y | 1 |
| Issa, JP | 1 |
| Batz, C; Claus, R; Flotho, C; Ihde, S; Lübbert, M; Niemeyer, CM; Plass, C; Sandrock, I; Schneider, M | 1 |
| Billam, M; Davidson, NE; Sobolewski, MD | 1 |
| Betham, B; Bhagwat, AS; Marquez, VE; Shalhout, S | 1 |
| Assaraf, YG; Bram, EE; Raz, S; Stark, M | 1 |
| Chan, JY; Ho, WK; Man, OY; To, VS; Tsang, CM; Tsang, RK; Tsao, SW; Wei, WI; Wong, TS | 1 |
| Arimondo, PB; Champion, C; Guianvarc'h, D; Guieysse-Peugeot, AL; Jeltsch, A; Jurkowska, RZ; Ponger, L; Sénamaud-Beaufort, C | 1 |
| Farkas, DL; Gertych, A; Tajbakhsh, J | 1 |
| Morales, JC; Rodríguez-Vargas, JM; Ruiz-Magaña, MJ; Ruiz-Ruiz, C; Saldivia, MA; Schulze-Osthoff, K | 1 |
| Bianco-Miotto, T; Butler, LM; Centenera, MM; Chiam, K; Tilley, WD | 1 |
| Barišić, D; Bosnar, MH; Horvat, T; Mužinić, A; Zoldoš, V | 1 |
| Chie, EK; Kim, HJ; Kim, IA; Kim, IH; Kim, JH; Young, PD | 1 |
| Haneef, K; Iqbal, H; Jamall, S; Kabir, N; Naeem, N; Salim, A | 1 |
| Chan, K; Covey, J; Ebrahem, Q; Engelke, KJ; Gu, X; Jankowska, A; Ling, Y; Maciejewski, J; Mahfouz, RZ; Radivoyevitch, T; Saunthararajah, Y; Sekeres, MA; Tabarroki, A; Terse, P; Tiu, R; Visconte, V | 1 |
| Gertych, A; Oh, JH; Tajbakhsh, J; Wawrowsky, KA; Weisenberger, DJ | 1 |
| Peng, M; Rothstein, SJ; Yaish, MW | 1 |
| Flis, K; Flis, S; Gnyszka, A | 1 |
| Arimany-Nardi, C; Errasti-Murugarren, E; Gorboulev, V; Koepsell, H; Martinez-Picado, J; Minuesa, G; Pastor-Anglada, M | 1 |
| Campbell, RR; Dang, D; Ono, K; Schmidt, BL; Viet, CT; Ye, Y | 1 |
| Levine, A; Sun, Y; Yi, L | 1 |
| D'Souza, S; Kang, TM; Lam, K; Miller, JH; Song, LY; Yeh, P | 1 |
| Griffin, PT; Niederhuth, CE; Schmitz, RJ | 1 |
| Ang, J; D'Souza, S; Hong, IL; Luhar, R; Miller, JH; Song, LY; Yung, M | 1 |
| Anglard, P; Befort, K; Filliol, D; Fonteneau, M; Romieu, P; Zwiller, J | 1 |
| Butter, R; Linnekamp, JF; Medema, JP; Spijker, R; van Laarhoven, HWM | 1 |
| Bohnsack, MT; Haag, S; Kretschmer, J; Sloan, KE | 1 |
| Dvořák Tomaštíková, E; Ercan, U; Finke, A; Krečmerová, M; Niezgodzki, I; Nowicka, A; Otmar, M; Pecinka, A; Poppenberger, B; Procházková, K; Rozhon, W; Schubert, I; Tokarz, B; Zwyrtková, J | 1 |
| Abd Elmageed, ZY; Ali, HEA; Buttolph, T; Carraway, HE; Cen, Y; Denvir, J; Fan, J; Fandy, TE; Malkaram, SA; Primerano, DA; Shatnawi, A | 1 |
7 review(s) available for cytidine and azacitidine
| Article | Year |
|---|---|
Mode of action and effects of 5-azacytidine and of its derivatives in eukaryotic cells.
Topics: Animals; Antimetabolites, Antineoplastic; Azacitidine; Cells; Cytidine; Drug Resistance; Enzyme Activation; Eukaryotic Cells; Humans; Leukemia, Experimental; Liver Regeneration; Uridine Kinase | 1985 |
New cancer chemotherapeutic agents.
Topics: Aldehydes; Amides; Amines; Animals; Antineoplastic Agents; Asparaginase; Azacitidine; Azaguanine; Bleomycin; Carmustine; Chlorides; Cyclization; Cyclohexanes; Cytarabine; Cytidine; Doxorubicin; Glycosides; Humans; Hydroxyurea; Imidazoles; Leukemia, Lymphoid; Leukemia, Myeloid; Mice; Nitrosourea Compounds; Picolinic Acids; Platinum; Podophyllotoxin; Streptozocin; Thiosemicarbazones; Triazenes | 1972 |
5-Azacytidine, DNA methylation, and differentiation.
Topics: 5-Methylcytosine; Azacitidine; Cell Differentiation; Cytidine; Cytosine; DNA; DNA (Cytosine-5-)-Methyltransferases; Dosage Compensation, Genetic; Female; Gene Expression Regulation; Genes, Viral; Methylation; Methyltransferases; Nucleic Acids; Phosphorylation; RNA, Transfer; X Chromosome | 1984 |
Inhibitors of DNA methylation in the treatment of hematological malignancies and MDS.
Topics: Acetylation; Azacitidine; Cytidine; Decitabine; DNA Methylation; Hematologic Neoplasms; Histones; Humans; Leukemia, Myeloid; Myelodysplastic Syndromes | 2003 |
Zebularine: a new drug for epigenetic therapy.
Topics: Azacitidine; Cytidine; DNA Methylation; Epigenesis, Genetic; Genetic Therapy; Humans; Neoplasms; Pyrimidine Nucleosides | 2004 |
Review: recent clinical trials in epigenetic therapy.
Topics: Animals; Antimetabolites, Antineoplastic; Azacitidine; Clinical Trials as Topic; Cytidine; Decitabine; DNA Methylation; Epigenesis, Genetic; Genetic Therapy; Histone Deacetylases; Humans; Myelodysplastic Syndromes | 2006 |
Clinical and biological effects of demethylating agents on solid tumours - A systematic review.
Topics: Antimetabolites, Antineoplastic; Azacitidine; Cytidine; Decitabine; DNA Methylation; Humans; Hydralazine; Immune System; Methylation; Neoplasms; Procaine; Treatment Outcome | 2017 |
2 trial(s) available for cytidine and azacitidine
| Article | Year |
|---|---|
Phase II study of 5-azacytidine (NSC-102816) in the treatment of advanced gastrointestinal cancer.
Topics: Adenocarcinoma; Adult; Aged; Azacitidine; Blood Cell Count; Blood Platelets; Clinical Trials as Topic; Cytidine; Female; Gastrointestinal Neoplasms; Humans; Leukocyte Count; Male; Middle Aged; Nausea; Triazines; Vomiting | 1972 |
5-Azacytidine: a new active agent for the treatment of acute leukemia.
Topics: Adolescent; Azacitidine; Bone Marrow Examination; Child; Child, Preschool; Chlorpromazine; Clinical Trials as Topic; Cytidine; Digestive System; Humans; Leukemia, Lymphoid; Leukemia, Myeloid, Acute; Nausea; Remission, Spontaneous; Triazines | 1973 |
95 other study(ies) available for cytidine and azacitidine
| Article | Year |
|---|---|
Cellular phosphorylation of 1-beta-D-arabinofuranosylcytosine 5-azacytidine with intact fibrosarcoma and leukemic cells.
Topics: Animals; Azacitidine; Binding, Competitive; Cells, Cultured; Cricetinae; Cytarabine; Cytidine; Deoxycytidine; Drug Resistance; Fibrosarcoma; Kinetics; Leukemia, Experimental; Mice; Phosphorus; Sarcoma, Experimental | 1975 |
Cytidine deaminase: a new genetic polymorphism demonstrated in human granulocytes.
Topics: Azacitidine; Cytarabine; Cytidine; Cytidine Deaminase; Cytosine; Electrophoresis, Starch Gel; Female; Granulocytes; Humans; Leukocytes; Male; Nucleoside Deaminases; Pedigree; Phenotype; Polymorphism, Genetic | 1975 |
Inhibition of protein synthesis in 5-azacytidine-treated HeLa cells.
Topics: Amino Acyl-tRNA Synthetases; Azacitidine; Cytidine; Depression, Chemical; HeLa Cells; Humans; Neoplasm Proteins; RNA, Neoplasm; RNA, Transfer; Uridine; Valine | 1976 |
Inhibition of uridine-cytidine kinase by 5-azacytidine 5'-triphosphate.
Topics: Azacitidine; Cytidine; Cytosine Nucleotides; Depression, Chemical; Feedback; Kinetics; Nucleotides; Phosphotransferases; Uridine Kinase | 1976 |
Characteristics of the enzyme uridine-cytidine kinase isolated from a cultured human cell line.
Topics: Azacitidine; Cell Line; Cytidine; Humans; Kinetics; Leukemia, Lymphoid; Phosphotransferases; Uridine; Uridine Kinase | 1977 |
Biological characterization of a prolonged antileukemic effect of 5-azacytidine.
Topics: Animals; Azacitidine; Bone Marrow; Bone Marrow Cells; Cell Division; Cell Survival; Cytidine; Dose-Response Relationship, Drug; Immunity; Leukemia L1210; Mice; Mice, Inbred DBA; Neoplasm Transplantation; Thymidine; Time Factors; Transplantation, Isogeneic | 1977 |
In vitro cytotoxic and biochemical effects of 5-aza-2'-deoxycytidine.
Topics: Azacitidine; Cell Division; Cell Survival; Cells, Cultured; Cytidine; Deoxycytidine; DNA, Neoplasm; Fibrosarcoma; Neoplasm Proteins; Neoplasms, Experimental; RNA, Neoplasm | 1977 |
Comparative studies of the cytostatic action and metabolism of 5-azacytidine and 5,6-dihydro-5-azacytidine.
Topics: Animals; Azacitidine; Cell Division; Cells, Cultured; Cytidine; Cytidine Deaminase; Deoxycytidine; Drug Synergism; Kinetics; Leukemia L1210; Oxidative Phosphorylation; Tetrahydrouridine; Thymidine; Uridine | 1977 |
Metabolism and cytotoxicity of 5-azacytidine in cultured Novikoff rat hepatoma and P388 mouse leukemia cells and their enhancement by preincubation with pyrazofurin.
Topics: Amides; Animals; Antibiotics, Antineoplastic; Azacitidine; Carcinoma, Hepatocellular; Cell Division; Cell Survival; Cytidine; DNA, Neoplasm; Drug Synergism; Leukemia, Experimental; Liver Neoplasms; Neoplasm Proteins; Neoplasms, Experimental; Phosphates; Pyrazoles; Ribonucleosides; Ribose; RNA, Neoplasm; Uridine | 1978 |
Effects of 5-azacytidine on transfer RNA methyltransferases.
Topics: Animals; Azacitidine; Cytidine; Dose-Response Relationship, Drug; Liver; Male; Mice; Mice, Inbred BALB C; RNA, Transfer; Time Factors; tRNA Methyltransferases | 1979 |
Uridine-cytidine kinase. IV. Kinetics of the competition between 5-azacytidine and the two natural substrates.
Topics: Animals; Azacitidine; Cytidine; In Vitro Techniques; Kinetics; Liver Neoplasms, Experimental; Mice; Models, Biological; Phosphotransferases; Substrate Specificity; Uridine; Uridine Kinase | 1979 |
Depression of DNA synthesis in mouse spleen after treatment with 5-aza-2'-deoxycytidine.
Topics: Animals; Azacitidine; Cytidine; Deoxycytidine; DNA; Female; Male; Mice; Nucleoside-Phosphate Kinase; Spleen; Thymidine; Thymidine Monophosphate | 1979 |
Potent inhibitors for the deamination of cytosine arabinoside and 5-aza-2'-deoxycytidine by human cytidine deaminase.
Topics: Antineoplastic Agents; Azacitidine; Azepines; Cytarabine; Cytidine; Cytidine Deaminase; Deamination; Decitabine; Humans; Kinetics; Pyrimidine Nucleosides; Tetrahydrouridine | 1992 |
5-Azacytidine inhibits the induction of transient TK-deficient cells by 5-bromodeoxyuridine. A novel hypothesis for the facilitation of hypermethylation by 5-bromodeoxyuridine.
Topics: Azacitidine; Bromodeoxyuridine; Cell Cycle; Chromatography, High Pressure Liquid; Cytidine; Deoxycytidine; DNA; Dose-Response Relationship, Drug; Drug Antagonism; Gene Expression Regulation; Humans; In Vitro Techniques; Methylation; Mutation; Thymidine Kinase | 1991 |
Sequence-dependent interaction of 5-fluorouracil and arabinosyl-5-azacytosine or 1-beta-D-arabinofuranosylcytosine.
Topics: Antineoplastic Combined Chemotherapy Protocols; Azacitidine; Cell Division; Cell Line; Cell Nucleus; Cell Survival; Colonic Neoplasms; Cytarabine; Cytidine; Deoxycytosine Nucleotides; DNA, Neoplasm; Drug Administration Schedule; Drug Interactions; Fluorouracil; Humans; Nucleic Acids; Thymine Nucleotides; Tumor Stem Cell Assay | 1991 |
Arabinosyl-5-azacytosine: mechanisms of native and acquired resistance.
Topics: Animals; Azacitidine; Biological Transport; Colonic Neoplasms; Cytidine; Deoxycytidine; Deoxycytidine Kinase; DNA; Drug Resistance; Humans; Leukemia P388; Mice; Phosphorylation | 1986 |
The mutagenicity of 5-azacytidine and other inhibitors of replicative DNA synthesis in the L5178Y mouse lymphoma cell.
Topics: Animals; Aphidicolin; Azacitidine; Cell Line; Cytidine; Diterpenes; Drug Resistance; Leukemia L5178; Leukemia, Experimental; Mice; Mutagens; Thymidine; Trifluridine | 1987 |
Genetic analysis of the 5-azacytidine sensitivity of Escherichia coli K-12.
Topics: Azacitidine; Cytidine; DNA (Cytosine-5-)-Methyltransferases; DNA Repair; DNA, Bacterial; Escherichia coli; Genes, Bacterial; Mutation; Phosphorylation; Rec A Recombinases; Recombination, Genetic; Uracil; Uridine | 1987 |
Suppression of nuclear ADP-ribosyltransferase activity in regenerating rat liver by 5-azacytidine and its relevance to the nuclear methylating activities.
Topics: Animals; Azacitidine; Cell Nucleus; Cytidine; DNA; Dose-Response Relationship, Drug; Female; Liver; Liver Regeneration; Methylation; Methyltransferases; Poly(ADP-ribose) Polymerase Inhibitors; Proteins; Rats; Rats, Inbred Strains; RNA | 1987 |
5-Azacytidine and 5-aza-2'-deoxycytidine behave as different antineoplastic agents in B16 melanoma.
Topics: Animals; Antineoplastic Agents; Azacitidine; Cell Survival; Cells, Cultured; Cytidine; Decitabine; Drug Resistance; Melanoma; Mice; Mutation; Uridine | 1987 |
5-azacytidine-induced increase in plasma prolactin levels of immature turkeys.
Topics: Animals; Azacitidine; Cytidine; Injections, Intravenous; Prolactin; Turkeys | 1988 |
Effect of different factors on liver thymidine monophosphate kinase in vivo and the synthesis of thymidine 5'-triphosphate in vitro.
Topics: Administration, Oral; Animals; Azacitidine; Cell-Free System; Cytidine; Enzyme Induction; Female; Hepatectomy; Leukemia, Experimental; Liver; Liver Regeneration; Mice; Mice, Inbred Strains; Rats; Thymidine Kinase; Thymine Nucleotides; Time Factors; Triazines; Tryptophan | 1972 |
[Photochemistry of anomalous nucleic acid building blocks. 8. Photochemistry of 6-azacytosine and 6-azacytidine].
Topics: Aza Compounds; Azacitidine; Chromatography; Cytidine; Cytosine; Photochemistry; Polarography; Spectrophotometry; Triazines | 1972 |
The components of the nucleoside-transporting system in Escherichia coli.
Topics: Adenosine; Azacitidine; Biological Transport; Carbon Isotopes; Cell Membrane; Coliphages; Cytidine; Deamination; Deoxyadenosines; Drug Resistance, Microbial; Escherichia coli; Kinetics; Mutation; Nucleosides; Osmosis; Phosphoric Acids; Thymidine; Tritium | 1972 |
Chromatid breakage: differential effect of inhibitors of DNA synthesis during G 2 phase.
Topics: Animals; Azacitidine; Azaguanine; Cell Line; Chromatids; Chromosome Aberrations; Cricetinae; Cytarabine; Cytidine; DNA; DNA Nucleotidyltransferases; Hydroxyurea; Lung; Mitosis; Oxidoreductases; Pyridines; Ribonucleotides; Thiosemicarbazones; Triazines | 1972 |
Depression of polyamine synthesis in L1210 leukemic mice during treatment with a potent antileukemic agent, 5-azacytidine.
Topics: Animals; Antineoplastic Agents; Azacitidine; Carboxy-Lyases; Cytidine; Depression, Chemical; Enzyme Repression; Injections, Intraperitoneal; Leukemia L1210; Liver; Male; Mice; Mice, Inbred Strains; Neoplasm Transplantation; Organ Size; Ornithine; Polyamines; Putrescine; S-Adenosylmethionine; Spermidine; Spleen; Triazines | 1973 |
Effect of 5-azacytidine on phytohemagglutinin-stimulated horse lymphocytes and cultured mouse L929 cells.
Topics: Animals; Antineoplastic Agents; Azacitidine; Cell Fractionation; Cells, Cultured; Cytidine; DNA; Dose-Response Relationship, Drug; Horses; L Cells; Lectins; Lymphocytes; Phosphorus Isotopes; Plasma Cells; Protein Biosynthesis; Proteins; RNA; Stimulation, Chemical; Time Factors; Triazines | 1973 |
Mechanism of resistance to 5-azacytidine in Bacillus subtilis. I. Isolation and some properties of mutants resistant to 5-azacytidine and 5-aza-2'-deoxycytidine.
Topics: Azacitidine; Bacillus subtilis; Culture Media; Cytidine; DNA, Bacterial; Drug Resistance, Microbial; Mutation; Transformation, Genetic; Triazines | 1972 |
Dual effect of 5-azacytidine on the synthesis of liver ribonucleic acids. Lack of the relationship between metabolic transformation of orotic acid in vitro and its incorporation in vivo.
Topics: Animals; Azacitidine; Biotransformation; Carbon Isotopes; Carboxy-Lyases; Cell-Free System; Cytidine; In Vitro Techniques; Isotope Labeling; Liver; Orotic Acid; Pentosyltransferases; Phosphotransferases; Rats; RNA; RNA, Ribosomal; RNA, Transfer; Time Factors; Triazines; Uridine | 1972 |
Prolongation of the lag period preceding the enhancement of thymidine and thymidylate kinase activity in regenerating rat liver by 5-azacytidine.
Topics: Animals; Azacitidine; Carbon Isotopes; Centrifugation, Density Gradient; Cytidine; DNA; Female; Hepatectomy; In Vitro Techniques; Liver; Liver Regeneration; Phosphotransferases; Protein Biosynthesis; Rats; Ribosomes; Sucrose; Thymidine; Thymidine Kinase; Thymine Nucleotides; Time Factors; Triazines; Valine | 1972 |
Enhanced uridine kinase in rat liver following 5-azacytidine administration. In vivo characterization and properties of partially purified enzyme.
Topics: Adrenal Glands; Animals; Azacitidine; Cell-Free System; Cytidine; Dactinomycin; DNA; Dose-Response Relationship, Drug; Drug Stability; Injections, Intraperitoneal; Liver; Male; Nucleotidases; Phosphoric Monoester Hydrolases; Phosphotransferases; Protein Biosynthesis; Rats; RNA; Time Factors; Triazines; Uracil Nucleotides; Uridine | 1973 |
Kinetics of the reduction in viability of cultured L1210 leukemia cells exposed to 5-azacytidine (NSC-102816).
Topics: Animals; Azacitidine; Cell Division; Cell Survival; Cells, Cultured; Chromatography, Paper; Cytidine; Hydrolysis; Kinetics; Leukemia L1210; Mice; Time Factors; Triazines | 1972 |
Pycnotic degeneration of ventricular cells in embryonic brain following transplacental exposure to 5-azacytidine.
Topics: Animals; Autoradiography; Azacitidine; Brain; Cell Nucleus; Cerebral Ventricles; Cytidine; DNA; Embryo, Mammalian; Female; Male; Maternal-Fetal Exchange; Mice; Mitosis; Pregnancy; Thymidine; Triazines; Tritium | 1972 |
Metabolic alterations of liver regeneration. 8. Enhanced synthesis of DNA in the liver of 5-azacytidine-treated rats subjected to partial hepatectomy.
Topics: Animals; Autoradiography; Azacitidine; Carbon Isotopes; Cell Division; Cytidine; Depression, Chemical; DNA; Female; Hepatectomy; Liver; Liver Regeneration; Methods; Orotic Acid; Pyrimidine Nucleotides; Rats; RNA; Stimulation, Chemical; Thymine Nucleotides; Time Factors; Triazines; Tritium; Uridine | 1972 |
Effects of 5-azacytidine on dietary and hormone induction of serine dehydratase and tyrosine aminotransferase in rat liver.
Topics: Adrenal Glands; Adrenalectomy; Animals; Azacitidine; Cortisone; Cytidine; Diet; Enzyme Induction; Kinetics; L-Serine Dehydratase; Leucine; Liver; Male; Precipitin Tests; Rabbits; Rats; Time Factors; Triazines; Tritium; Tryptophan; Tyrosine Transaminase | 1972 |
Effect of 5-azacytidine and 6-azauridine on the synthesis of DNA in embryonic mouse brain mitotic activity and migration of ventricular cells.
Topics: Animals; Autoradiography; Azacitidine; Azauridine; Brain; Cell Movement; Cerebral Ventricles; Cytidine; DNA; Female; Mice; Mitosis; Pregnancy; Thymidine; Time Factors; Triazines; Tritium | 1973 |
Hepatotoxicity of 5-azacytidine (NSC-102816) (a clinical and pathologic study).
Topics: Acute Disease; Adult; Aged; Azacitidine; Chemical and Drug Induced Liver Injury; Cytidine; Female; Humans; Kupffer Cells; Liver; Male; Middle Aged; Neoplasms; Triazines | 1973 |
Studies on the mechanism of the stimulation of tyrosine aminotransferase activity in vivo by pyrimidine analogs: the role of enzyme synthesis and degradation.
Topics: Adrenalectomy; Animals; Azacitidine; Carbon Isotopes; Caseins; Cortisone; Cytidine; Drug Stability; Enzyme Induction; Fasting; Immunodiffusion; L-Serine Dehydratase; Liver; Male; Orotic Acid; Protein Hydrolysates; Rabbits; Rats; Time Factors; Triazines; Tritium; Tyrosine Transaminase | 1973 |
Deamination of 5-azacytidine by a human leukemia cell cytidine deaminase.
Topics: Aminohydrolases; Azacitidine; Blood Proteins; Carbon Radioisotopes; Chromatography, Ion Exchange; Cytarabine; Cytidine; Deamination; Humans; In Vitro Techniques; Kinetics; Leukemia, Myeloid; Leukocytes; Spectrophotometry, Ultraviolet | 1973 |
Inhibition of ribosomal ribonucleic acid maturation by 5-azacytidine and 8-azaguanine in Novikoff hepatoma cells.
Topics: Animals; Azacitidine; Azaguanine; Carcinoma, Hepatocellular; Cells, Cultured; Cytidine; Dactinomycin; Electrophoresis, Polyacrylamide Gel; Fluorouracil; Guanosine; Isotope Labeling; Liver; Liver Neoplasms; Neoplasms, Experimental; Rats; RNA, Neoplasm; RNA, Ribosomal; Spectrophotometry, Ultraviolet; Time Factors; Tritium; Uridine | 1974 |
Kinetic studies on phosphorylation of 5-azacytidine with the purified uridine-cytidine kinase from calf thymus.
Topics: Animals; Azacitidine; Carbon Radioisotopes; Cattle; Chromatography, DEAE-Cellulose; Cytidine; Cytosine Nucleotides; Kinetics; Magnesium; Oxidative Phosphorylation; Phosphotransferases; Thymus Gland; Uracil Nucleotides; Uridine | 1974 |
[Morphological-physiological investigation on the effect of 5-azacytidine in the nucleolus].
Topics: Animals; Autoradiography; Azacitidine; Cell Nucleolus; Cytidine; HeLa Cells; Histocytochemistry; Humans; In Vitro Techniques; Liver; Mice; Microscopy, Electron; Tritium | 1973 |
Cellular differentiation, cytidine analogs and DNA methylation.
Topics: Adipose Tissue; Animals; Azacitidine; Cell Differentiation; Cells, Cultured; Cytarabine; Cytidine; Decitabine; Deoxycytidine; DNA; DNA (Cytosine-5-)-Methyltransferases; Methylation; Methyltransferases; Mice; Muscles; Structure-Activity Relationship | 1980 |
Effects of 5-azacytidine on transfer RNA modification: comparative study on normal and malignant tissues.
Topics: Animals; Azacitidine; Cytidine; Mice; Neoplasms, Experimental; Rats; RNA, Transfer; tRNA Methyltransferases | 1980 |
Effect of N-(phosphonacetyl)-L-aspartate on 5-azacytidine metabolism in P388 and L1210 cells.
Topics: Animals; Aspartate Carbamoyltransferase; Aspartic Acid; Azacitidine; Cell Division; Cytidine; DNA, Neoplasm; Leukemia L1210; Leukemia, Experimental; Mice; Neoplasm Proteins; Organophosphorus Compounds; Phosphonoacetic Acid; RNA, Neoplasm; Uridine | 1981 |
5-Azacytidine induction of mouse endogenous type C virus and suppression of DNA methylation.
Topics: Animals; Azacitidine; Bromodeoxyuridine; Cell Line; Cytidine; Deoxycytidine; DNA Replication; DNA, Viral; Dose-Response Relationship, Drug; Kinetics; Mice; Mice, Inbred BALB C; Retroviridae; Virus Replication | 1981 |
Mechanism of action of eukaryotic DNA methyltransferase. Use of 5-azacytosine-containing DNA.
Topics: Animals; Azacitidine; Cells, Cultured; Cytidine; DNA (Cytosine-5-)-Methyltransferases; DNA, Single-Stranded; Methylation; Methyltransferases; Mice; Osmolar Concentration | 1982 |
Specific effects of 5-fluoropyrimidines and 5-azapyrimidines on modification of the 5 position of pyrimidines, in particular the synthesis of 5-methyluracil and 5-methylcytosine in nucleic acids.
Topics: 5-Methylcytosine; Animals; Azacitidine; Cytidine; Cytosine; DNA; Liver; Methylation; Mice; Pyrimidines; RNA, Transfer; Thymine | 1983 |
Cytidine metabolism in photoreceptor cells of the rat.
Topics: Animals; Autoradiography; Azacitidine; Cytidine; Cytidine Diphosphate Diglycerides; Dactinomycin; Light; Nucleoside Diphosphate Sugars; Phosphatidylinositols; Photoreceptor Cells; Rats; Retina; RNA | 1983 |
Effects of the umuDC, mucAB, and samAB operons on the mutational specificity of chemical mutagenesis in Escherichia coli: II. Base substitution mutagenesis.
Topics: Aminacrine; Azacitidine; Cross-Linking Reagents; Cytidine; DNA Mutational Analysis; DNA, Bacterial; Escherichia coli; Furylfuramide; Intercalating Agents; Lac Operon; Methylnitronitrosoguanidine; Mitomycin; Mutagenesis, Site-Directed; Mutagens; Nitrogen Mustard Compounds; Operon; Plasmids; Point Mutation; SOS Response, Genetics; Suppression, Genetic; Ultraviolet Rays | 1994 |
Polarographic reduction and carcinogenic index tg alpha of 5-aza nucleosides possessing antileukemic activity.
Topics: Antineoplastic Agents; Azacitidine; Carcinogens; Cytarabine; Cytidine; Molecular Structure; Oxidation-Reduction; Polarography; Structure-Activity Relationship | 1993 |
Enhancement of the antileukemic activity of 5-aza-2'-deoxycytidine by cyclopentenyl cytosine in HL-60 leukemic cells.
Topics: Antineoplastic Agents; Azacitidine; Cell Division; Cytidine; Cytidine Deaminase; Decitabine; Deoxycytosine Nucleotides; DNA, Neoplasm; Drug Synergism; Humans; Leukemia, Experimental; Tumor Cells, Cultured | 1994 |
Possible involvement of DNA methylation in 5-azacytidine-induced neuronal cell apoptosis.
Topics: Animals; Apoptosis; Azacitidine; Cytidine; DNA Methylation; Female; Mice; Mice, Inbred ICR; Neurons; Nucleosides; PC12 Cells; Rats | 1999 |
A comparison of mutation spectra detected by the Escherichia coli lac(+) reversion assay and the Salmonella typhimurium his(+) reversion assay.
Topics: 2-Aminopurine; 4-Nitroquinoline-1-oxide; Alkylating Agents; Azacitidine; Benzene Derivatives; Cytidine; DNA; DNA Mutational Analysis; Dose-Response Relationship, Drug; Escherichia coli; Ethylnitrosourea; Formaldehyde; Furans; Furylfuramide; Glyoxal; Histidine; Lac Operon; Methylnitronitrosoguanidine; Mutagenicity Tests; Mutagens; Oxidants; Phosmet; Plasmids; Point Mutation; Salmonella typhimurium; Sodium Azide; tert-Butylhydroperoxide; Uracil | 2000 |
Positive and negative transcriptional states of a variegating immunoglobulin heavy chain (IgH) locus are maintained by a cis-acting epigenetic mechanism.
Topics: Alleles; Animals; Azacitidine; Cell Differentiation; Cell Fusion; Cell Line; Clone Cells; Cytidine; DNA Methylation; Enhancer Elements, Genetic; Genetic Markers; Hybridomas; Immunoglobulin Class Switching; Immunoglobulin Heavy Chains; Immunoglobulin mu-Chains; Introns; Locus Control Region; Matrix Attachment Region Binding Proteins; Mice; Transcription, Genetic; Transgenes | 2002 |
Synthesis and anti-cancer activity of some novel 5-azacytosine nucleosides.
Topics: Antineoplastic Agents; Azacitidine; Carbohydrate Conformation; Cell Line, Tumor; Cell Survival; Cytidine; Cytosine; Drug Screening Assays, Antitumor; Humans; Magnetic Resonance Spectroscopy; Molecular Structure; Pentoses; Pyrimidine Nucleosides; Sulfur Compounds | 2003 |
Continuous zebularine treatment effectively sustains demethylation in human bladder cancer cells.
Topics: Azacitidine; Cytidine; Decitabine; DNA; DNA (Cytosine-5-)-Methyltransferase 1; DNA (Cytosine-5-)-Methyltransferases; DNA Methylation; Enzyme Inhibitors; Gene Silencing; Genes, p16; Humans; Pyrimidine Nucleosides; Urinary Bladder Neoplasms | 2004 |
The in vitro and in vivo effects of re-expressing methylated von Hippel-Lindau tumor suppressor gene in clear cell renal carcinoma with 5-aza-2'-deoxycytidine.
Topics: Adenocarcinoma, Clear Cell; Animals; Antimetabolites, Antineoplastic; Azacitidine; Cytidine; Decitabine; Disease Models, Animal; DNA Methylation; Gene Silencing; Humans; Kidney Neoplasms; Mice; Pyrimidine Nucleosides; Reverse Transcriptase Polymerase Chain Reaction; Transfection; Transplantation, Heterologous; Tumor Cells, Cultured; Tumor Suppressor Proteins; Ubiquitin-Protein Ligases; Von Hippel-Lindau Tumor Suppressor Protein | 2004 |
Enhancement of antineoplastic action of 5-aza-2'-deoxycytidine by zebularine on L1210 leukemia.
Topics: Animals; Antimetabolites, Antineoplastic; Azacitidine; Cell Line, Tumor; Cytidine; Cytidine Deaminase; Decitabine; DNA Methylation; Dose-Response Relationship, Drug; Drug Interactions; Humans; Leukemia L1210; Male; Mice; Pyrimidine Nucleosides; Reverse Transcriptase Polymerase Chain Reaction; Tumor Stem Cell Assay | 2005 |
Interleukin 6 supports the maintenance of p53 tumor suppressor gene promoter methylation.
Topics: Apoptosis; Azacitidine; Base Sequence; Cell Cycle; Cell Line, Tumor; Cytidine; Decitabine; Deoxycytidine; DNA (Cytosine-5-)-Methyltransferase 1; DNA (Cytosine-5-)-Methyltransferases; DNA Methylation; Gene Silencing; Genes, p53; Humans; Interleukin-6; Molecular Sequence Data; Multiple Myeloma; Promoter Regions, Genetic; Sulfites; Tumor Suppressor Protein p53 | 2005 |
Antimitogenic and chemosensitizing effects of the methylation inhibitor zebularine in ovarian cancer.
Topics: Antineoplastic Combined Chemotherapy Protocols; Azacitidine; Cell Growth Processes; Cell Line, Tumor; Cisplatin; Cytidine; Decitabine; DNA Methylation; Drug Synergism; Female; Gene Expression Regulation, Neoplastic; Gene Silencing; Genes, Tumor Suppressor; Humans; Ovarian Neoplasms | 2005 |
Comparison of biological effects of non-nucleoside DNA methylation inhibitors versus 5-aza-2'-deoxycytidine.
Topics: Antimetabolites, Antineoplastic; Azacitidine; Carcinoma, Transitional Cell; Catechin; Cell Line, Tumor; Colorectal Neoplasms; Cytidine; Decitabine; Deoxycytidine; DNA Methylation; DNA Modification Methylases; Enzyme Inhibitors; Female; Gene Silencing; HT29 Cells; Humans; Hydralazine; Male; Procainamide; Prostatic Neoplasms; Reverse Transcriptase Polymerase Chain Reaction | 2005 |
Angiostatic activity of DNA methyltransferase inhibitors.
Topics: Acetylation; Angiogenesis Inhibitors; Animals; Azacitidine; Cell Movement; Cytidine; DNA Modification Methylases; Endothelial Cells; Enzyme Inhibitors; Gene Expression; Histones; Humans; Hydroxamic Acids; Insulin-Like Growth Factor Binding Protein 3; Melanoma, Experimental; Mice; Mice, Mutant Strains; Neovascularization, Pathologic; Neovascularization, Physiologic; Thrombospondin 1 | 2006 |
Functional diversity of DNA methyltransferase inhibitors in human cancer cell lines.
Topics: Azacitidine; Catechin; Cell Line, Tumor; Cytidine; Decitabine; DNA (Cytosine-5-)-Methyltransferases; DNA Methylation; Enzyme Inhibitors; Humans; Indoles; Jurkat Cells; Phthalimides; Procaine; Propionates; Tryptophan | 2006 |
DNA methyltransferase inhibitors coordinately induce expression of the human reelin and glutamic acid decarboxylase 67 genes.
Topics: Acetylation; Azacitidine; Cell Adhesion Molecules, Neuronal; Cells, Cultured; Cytidine; Decitabine; DNA (Cytosine-5-)-Methyltransferase 1; DNA (Cytosine-5-)-Methyltransferases; Dose-Response Relationship, Drug; Doxorubicin; Enzyme Inhibitors; Extracellular Matrix Proteins; Gene Expression Regulation; Glutamate Decarboxylase; Histones; Humans; Isoenzymes; Methyl-CpG-Binding Protein 2; Nerve Tissue Proteins; Reelin Protein; RNA, Messenger; Serine Endopeptidases | 2007 |
Methylation of tumour suppressor genes APAF-1 and DAPK-1 and in vitro effects of demethylating agents in bladder and kidney cancer.
Topics: Aged; Antimetabolites, Antineoplastic; Apoptosis Regulatory Proteins; Apoptotic Protease-Activating Factor 1; Azacitidine; Calcium-Calmodulin-Dependent Protein Kinases; Carcinoma, Renal Cell; Carcinoma, Transitional Cell; Cells, Cultured; Cytidine; Death-Associated Protein Kinases; DNA Methylation; Female; Gene Expression Regulation, Neoplastic; Humans; In Vitro Techniques; Kidney; Kidney Neoplasms; Male; Promoter Regions, Genetic; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Urinary Bladder; Urinary Bladder Neoplasms | 2006 |
Zebularine reactivates silenced E-cadherin but unlike 5-Azacytidine does not induce switching from latent to lytic Epstein-Barr virus infection in Burkitt's lymphoma Akata cells.
Topics: Antineoplastic Agents; Azacitidine; Burkitt Lymphoma; Cadherins; Cytidine; Gene Silencing; Herpesvirus 4, Human; Humans; Tumor Cells, Cultured; Virus Latency | 2007 |
Inhibition of cytidine deaminase by zebularine enhances the antineoplastic action of 5-aza-2'-deoxycytidine.
Topics: 3T3 Cells; Animals; Antineoplastic Agents; Azacitidine; Cytidine; Cytidine Deaminase; Decitabine; Drug Synergism; Enzyme Inhibitors; Leukemia, Experimental; Male; Mice; Mice, Inbred BALB C; Mice, Inbred DBA | 2009 |
Cancer prevention: epigenetics steps up to the plate.
Topics: Antimetabolites, Antineoplastic; Azacitidine; Cell Transformation, Neoplastic; Chemoprevention; Cytidine; Decitabine; DNA (Cytosine-5-)-Methyltransferases; DNA Methylation; Enzyme Inhibitors; Epigenesis, Genetic; Humans; Models, Biological; Neoplasms | 2008 |
The DNA methyltransferase inhibitors azacitidine, decitabine and zebularine exert differential effects on cancer gene expression in acute myeloid leukemia cells.
Topics: Antimetabolites, Antineoplastic; Apoptosis; Azacitidine; Cell Differentiation; Cell Line, Tumor; Cell Proliferation; Cytidine; Decitabine; DNA Methylation; DNA Modification Methylases; Enzyme Inhibitors; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Humans; Leukemia, Myeloid, Acute | 2009 |
Effects of a novel DNA methyltransferase inhibitor zebularine on human breast cancer cells.
Topics: Adenocarcinoma; Apoptosis Regulatory Proteins; Azacitidine; Breast Neoplasms; Cell Cycle Proteins; Cell Line, Tumor; Chromatin Immunoprecipitation; Cytidine; Cytidine Deaminase; Decitabine; DNA (Cytosine-5-)-Methyltransferases; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Drug Synergism; Enzyme Inhibitors; Female; Gene Expression Regulation, Neoplastic; Humans; Hydroxamic Acids; Neoplasm Proteins; Receptors, Estrogen; S Phase; Tumor Stem Cell Assay; Vorinostat | 2010 |
Use of Drosophila deoxynucleoside kinase to study mechanism of toxicity and mutagenicity of deoxycytidine analogs in Escherichia coli.
Topics: Animals; Antineoplastic Agents; Azacitidine; Cytidine; Deoxycytidine; DNA; DNA Methylation; DNA Mismatch Repair; Drosophila melanogaster; Escherichia coli; Fluorescence; Microbial Sensitivity Tests; Mutagenesis; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor) | 2010 |
Chemotherapeutic drug-induced ABCG2 promoter demethylation as a novel mechanism of acquired multidrug resistance.
Topics: Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Azacitidine; Cell Line, Tumor; Cell Proliferation; Cytidine; Decitabine; DNA Methylation; Drug Resistance, Neoplasm; Gene Expression Regulation, Neoplastic; Humans; Jurkat Cells; K562 Cells; Neoplasm Proteins; Precursor T-Cell Lymphoblastic Leukemia-Lymphoma; Promoter Regions, Genetic; Reverse Transcriptase Polymerase Chain Reaction | 2009 |
MicroRNA let-7 suppresses nasopharyngeal carcinoma cells proliferation through downregulating c-Myc expression.
Topics: Azacitidine; Carcinoma; Cell Growth Processes; Cell Line, Tumor; Cytidine; DNA Methylation; Down-Regulation; Gene Expression Regulation, Neoplastic; Humans; Immunohistochemistry; MicroRNAs; Nasopharyngeal Carcinoma; Nasopharyngeal Neoplasms; Proto-Oncogene Proteins c-myc; Transfection; Up-Regulation | 2011 |
Mechanistic insights on the inhibition of c5 DNA methyltransferases by zebularine.
Topics: Animals; Azacitidine; Base Sequence; Cytidine; Decitabine; DNA; DNA (Cytosine-5-)-Methyltransferases; Enzyme Inhibitors; Humans; Methylation; Mice | 2010 |
Measuring topology of low-intensity DNA methylation sites for high-throughput assessment of epigenetic drug-induced effects in cancer cells.
Topics: Antineoplastic Agents; Azacitidine; Cell Line, Tumor; Cell Nucleus; Cytidine; Cytosine; DNA Methylation; DNA, Neoplasm; Epigenesis, Genetic; Fluorescence; High-Throughput Screening Assays; Humans; Indoles; Neoplasms; Nucleic Acid Conformation | 2010 |
The DNA methyltransferase inhibitors zebularine and decitabine induce mitochondria-mediated apoptosis and DNA damage in p53 mutant leukemic T cells.
Topics: Apoptosis; Azacitidine; Caspase 9; Cell Cycle; Cell Line, Tumor; Cytidine; Decitabine; DNA (Cytosine-5-)-Methyltransferases; DNA Damage; Genes, p53; Humans; Leukemia, T-Cell; Mitochondria; Mutation; Reactive Oxygen Species; T-Lymphocytes | 2012 |
GSTP1 DNA methylation and expression status is indicative of 5-aza-2'-deoxycytidine efficacy in human prostate cancer cells.
Topics: Azacitidine; Biomarkers, Tumor; Cell Death; Cell Line, Tumor; Cell Proliferation; Cell Survival; Cytidine; Decitabine; DNA Methylation; Dose-Response Relationship, Drug; Drug Discovery; Enzyme Inhibitors; Gene Expression Regulation, Neoplastic; Gene Silencing; Glutathione S-Transferase pi; Humans; Male; Promoter Regions, Genetic; Prostate-Specific Antigen; Prostatic Neoplasms; Time Factors | 2011 |
Epigenetic modulation of the HeLa cell membrane N-glycome.
Topics: Antineoplastic Agents; Azacitidine; Butyrates; Carbohydrate Sequence; Cytidine; Decitabine; DNA Methylation; Epigenesis, Genetic; Gene Expression Regulation, Neoplastic; Glycomics; HeLa Cells; Histone Deacetylase Inhibitors; Humans; Hydroxamic Acids; Molecular Sequence Data; Polysaccharides | 2012 |
DNMT (DNA methyltransferase) inhibitors radiosensitize human cancer cells by suppressing DNA repair activity.
Topics: Azacitidine; Caspase 3; Catechin; Cell Line, Tumor; Cytidine; Decitabine; Disulfides; DNA (Cytosine-5-)-Methyltransferase 1; DNA (Cytosine-5-)-Methyltransferases; DNA Breaks, Double-Stranded; DNA Methyltransferase 3A; DNA Methyltransferase 3B; DNA Repair; Enzyme Induction; Gene Expression Regulation, Neoplastic; Glioblastoma; Histones; Humans; Hydralazine; Inhibitory Concentration 50; Lung Neoplasms; Neoplasm Proteins; Radiation-Sensitizing Agents; Tumor Stem Cell Assay; Tyrosine | 2012 |
DNA methylation inhibitors, 5-azacytidine and zebularine potentiate the transdifferentiation of rat bone marrow mesenchymal stem cells into cardiomyocytes.
Topics: Animals; Azacitidine; Bone Marrow Cells; Cell Fusion; Cell Transdifferentiation; Cells, Cultured; Coculture Techniques; Cytidine; DNA Methylation; DNA Modification Methylases; Dose-Response Relationship, Drug; Enzyme Inhibitors; Female; GATA4 Transcription Factor; Gene Expression Regulation; Homeobox Protein Nkx-2.5; Homeodomain Proteins; Male; Mesenchymal Stem Cells; Myocytes, Cardiac; Rats; Rats, Sprague-Dawley; RNA, Messenger; Transcription Factors; Troponin T | 2013 |
Increased CDA expression/activity in males contributes to decreased cytidine analog half-life and likely contributes to worse outcomes with 5-azacytidine or decitabine therapy.
Topics: Animals; Azacitidine; Cytarabine; Cytidine; Cytidine Deaminase; Decitabine; DNA (Cytosine-5-)-Methyltransferase 1; DNA (Cytosine-5-)-Methyltransferases; Female; Gene Expression Regulation, Neoplastic; Humans; Leukemia, Myeloid, Acute; Male; Mice; Myelodysplastic Syndromes; Polymorphism, Single Nucleotide; Survival Analysis; Treatment Outcome | 2013 |
3-D DNA methylation phenotypes correlate with cytotoxicity levels in prostate and liver cancer cell models.
Topics: 5-Methylcytosine; Antibodies, Monoclonal; Antineoplastic Agents; Apoptosis; Azacitidine; Cell Line, Tumor; Cell Survival; Cytidine; DNA Methylation; Humans; Liver Neoplasms; Male; Phenotype; Prostatic Neoplasms | 2013 |
Global DNA methylation analysis using methyl-sensitive amplification polymorphism (MSAP).
Topics: Arabidopsis; Azacitidine; Base Sequence; Cytidine; Decitabine; DNA Methylation; DNA, Plant; Polymerase Chain Reaction; Polymorphism, Genetic; Seeds | 2014 |
DNA methyltransferase inhibitors improve the effect of chemotherapeutic agents in SW48 and HT-29 colorectal cancer cells.
Topics: Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Azacitidine; Cell Cycle; Cell Line, Tumor; Colorectal Neoplasms; Cytidine; Decitabine; DNA Damage; DNA-Cytosine Methylases; Enzyme Inhibitors; Fluorouracil; Humans; Membrane Potential, Mitochondrial; Organoplatinum Compounds; Oxaliplatin | 2014 |
Nucleoside transporters and human organic cation transporter 1 determine the cellular handling of DNA-methyltransferase inhibitors.
Topics: Animals; Azacitidine; Biological Transport; Cell Survival; Cytidine; Decitabine; DNA Modification Methylases; Dogs; HeLa Cells; Humans; Madin Darby Canine Kidney Cells; Nucleoside Transport Proteins; Oocytes; Organic Cation Transporter 1; Xenopus laevis | 2014 |
Demethylating drugs as novel analgesics for cancer pain.
Topics: Analgesics, Opioid; Animals; Antineoplastic Agents; Azacitidine; Carcinoma, Squamous Cell; Cytidine; Decitabine; Disease Models, Animal; DNA Methylation; Heterografts; Humans; Immunohistochemistry; In Situ Hybridization; Mice; Mouth Neoplasms; Neurons; Pain; Receptors, Opioid, mu; Reverse Transcriptase Polymerase Chain Reaction; Transduction, Genetic; Trigeminal Ganglion | 2014 |
Selected drugs that inhibit DNA methylation can preferentially kill p53 deficient cells.
Topics: Animals; Anticarcinogenic Agents; Azacitidine; Catechin; Cell Line, Tumor; Cell Proliferation; Cytidine; Decitabine; DNA Methylation; Humans; Lung Neoplasms; Mice; Mice, Inbred C57BL; Mice, Knockout; Mutation; Neoplasm Transplantation; Phthalimides; Tryptophan; Tumor Suppressor Protein p53; Xenograft Model Antitumor Assays | 2014 |
Exploring Synergy between Classic Mutagens and Antibiotics To Examine Mechanisms of Synergy and Antibiotic Action.
Topics: 2-Aminopurine; 4-Nitroquinoline-1-oxide; Anti-Bacterial Agents; Azacitidine; Bromodeoxyuridine; Chloramphenicol; Ciprofloxacin; Cytidine; DNA Breaks, Double-Stranded; Drug Synergism; Erythromycin; Escherichia coli; Gentamicins; Microbial Sensitivity Tests; Mutagens; Tetracycline; Trimethoprim; Vancomycin | 2015 |
A Comparative Analysis of 5-Azacytidine- and Zebularine-Induced DNA Demethylation.
Topics: Arabidopsis; Azacitidine; Cytidine; DNA Methylation; Gene Expression Regulation, Plant; Gene Silencing; Transcriptome | 2016 |
Mutagen Synergy: Hypermutability Generated by Specific Pairs of Base Analogs.
Topics: Azacitidine; Base Pairing; Bromodeoxyuridine; Cytidine; Drug Synergism; Escherichia coli; Escherichia coli Proteins; Mutagens; Mutation | 2016 |
Inhibition of DNA methyltransferases regulates cocaine self-administration by rats: a genome-wide DNA methylation study.
Topics: Animals; Azacitidine; Brain; Cocaine; Cocaine-Related Disorders; CpG Islands; Cytidine; Decitabine; DNA; DNA Methylation; DNA Modification Methylases; Enzyme Inhibitors; Epigenesis, Genetic; Genome; Male; Phosphatidylinositol 3-Kinases; Promoter Regions, Genetic; Rats; Rats, Wistar; Reinforcement, Psychology; Self Administration | 2017 |
Crosslinking Methods to Identify RNA Methyltransferase Targets In Vivo.
Topics: Azacitidine; Chromatography, Affinity; Computational Biology; Cytidine; High-Throughput Nucleotide Sequencing; Methyltransferases; RNA; Statistics as Topic; Substrate Specificity; Ultraviolet Rays | 2017 |
Comparative analysis of epigenetic inhibitors reveals different degrees of interference with transcriptional gene silencing and induction of DNA damage.
Topics: Adenosine; Arabidopsis; Azacitidine; Chromosome Aberrations; Cytidine; Decitabine; DNA Damage; DNA Methylation; DNA Repair; Epigenesis, Genetic; Gene Silencing; Heterochromatin; RNA Interference; Tandem Repeat Sequences | 2020 |
Activation of SIRT6 by DNA hypomethylating agents and clinical consequences on combination therapy in leukemia.
Topics: Acetylation; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Azacitidine; Bone Marrow; Cell Line, Tumor; Cytidine; Decitabine; DNA Methylation; Histones; Humans; Leukemia, Myeloid, Acute; Sirtuins | 2020 |