Compounds > cytidine
Page last updated: 2024-08-17

cytidine and 2'-c-methylcytidine

cytidine has been researched along with 2'-c-methylcytidine in 37 studies

Research

Studies (37)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's14 (37.84)29.6817
2010's21 (56.76)24.3611
2020's2 (5.41)2.80

Authors

AuthorsStudies
Bao, H; Furman, PA; McBrayer, TR; Micolochick Steuer, HM; Murakami, E; Obikhod, A; Otto, MJ; Ramesh, M; Schinazi, RF; Stuyver, LJ; Whitaker, T1
Bao, H; Furman, PA; Micolochick Steuer, HM; Murakami, E; Nachman, T; Niu, C; Otto, MJ; Sofia, MA; Wang, P; Whitaker, T1
Ichikawa, S; Matsuda, A; Minakawa, N; Sasaki, T; Shuto, S; Tanaka, M1
Ali, S; Cammack, N; Jiang, S; Jiang, WR; Kang, H; Klumpp, K; Le Pogam, S; Leveque, V; Ma, H; Nájera, I; Rajyaguru, S; Singer, M; Smith, D; Symons, J1
Boretto, J; Bussetta, C; Canard, B; Dutartre, H1
Bartenschlager, R; Coelmont, L; De Clercq, E; Neyts, J; Paeshuyse, J; Windisch, MP1
De Clercq, K; De Palma, A; Goris, N; Musch, I; Neyts, J; Toussaint, JF1
Amador, A; Benzaria, S; Bridges, EG; Cretton-Scott, E; D'Amours, M; Gosselin, G; Mao, J; Mathieu, S; Moussa, A; Pierra, C; Sommadossi, JP; Standring, DN; Storer, R1
Cellai, L; D'Abramo, CM; Deval, J; Götte, M; Powdrill, MH1
Bassit, L; Bennett, M; Grier, J; Schinazi, RF1
Elazar, M; Glenn, JS; Korba, BE; Lui, P; Rossignol, JF1
Attenni, B; Donghi, M; Fiore, F; Gardelli, C; Giuliano, C; Laufer, R; Leone, JF; Marco, AD; Narjes, F; Pucci, V; Rowley, M1
Altamura, S; Bazzo, R; Di Marco, A; Fiore, F; Gardelli, C; Giuliano, C; Gonzalez-Paz, O; Koch, U; Koeplinger, KA; Laufer, R; Leone, JF; Meppen, M; Narjes, F; Pacini, B; Pucci, V; Rowley, M1
Attenni, B; Di Marco, A; Donghi, M; Fiore, F; Gardelli, C; Gennari, N; Giuliano, C; Harper, S; Laufer, R; Leone, JF; MacCoss, M; Marcucci, I; Meppen, M; Narjes, F; Olsen, DB; Pacini, B; Pucci, V; Rowley, M1
Cretton-Scott, E; Danehy, FT; Fellows, R; Golitsina, NL; Standring, DN1
Choi, JA; Chu, CK; Jha, AK; Julander, JG; Jung, KH; Morrey, JD; Smee, DF1
Attenni, B; Cianetti, S; Cooper, VB; Fiore, F; Gardelli, C; Giuliano, C; Laufer, R; Monteagudo, E; Narjes, F; Pearce, GE; Pucci, V; Rowley, M1
Boyer, SH; Carroll, SS; Erion, MD; Fujitaki, JM; Handt, L; Hecker, SJ; Koeplinger, K; Linemeyer, DL; MacCoss, M; Olsen, DB; Reddy, KR; Sun, Z; van Poelje, PD; Vavrek, M; Zhang, NR1
Chang, FR; Chiu, CC; Lee, JC; Tseng, CK; Wu, SF; Wu, YC1
Costa, I; Cunha, R; Dallmeier, K; Jochmans, D; Leyssen, P; Nascimento, MS; Neyts, J; Rocha-Pereira, J1
Billiet, A; De Clercq, K; De Vleeschauwer, AR; Goris, N; Kollanur, D; Lefebvre, DJ; Murao, L; Neyts, J1
Debing, Y; Jochmans, D; Nascimento, MS; Neyts, J; Rocha-Pereira, J; Verbeken, E1
Feigelstock, DA; Mihalik, KB1
De Clercq, K; De Vleeschauwer, AR; Goris, N; Kollanur, D; Lefebvre, DJ; Murao, LE; Neyts, J; Osiceanu, AM; Swinnen, J1
Bird, BH; Dodd, KA; Flint, M; Khristova, ML; McMullan, LK; Nichol, ST; Spiropoulou, CF1
Hilgenfeld, R; Jochmans, D; Ma, Q; Nascimento, MS; Neyts, J; Rocha-Pereira, J1
Jochmans, D; Neyts, J; Rocha-Pereira, J1
Chen, WC; Kaushik-Basu, N; Lee, JC; Lin, CK; Tseng, CK; Wu, HN; Wu, YH1
Černý, J; De Clercq, E; Eyer, L; Gil, VA; Hřebabecký, H; Nencka, R; Palus, M; Růžek, D; Šála, M; Salát, J; Valdés, JJ1
Behera, I; Beigelman, L; Deval, J; Dyatkina, N; Jin, Z; Kao, CC; Lin, X; Rajwanshi, VK; Shaw, K; Symons, J; Tan, H; Tucker, K; Wang, G1
Neyts, J; Rocha-Pereira, J; Van Dycke, J1
Backlund, A; Chang, FR; Chen, SR; Cheng, YB; Hu, HC; Lee, JC; Wu, YC; Wu, YH1
Pan, Q; Peppelenbosch, MP; Qu, C; Wang, W; Xu, L; Yin, Y1
Fumian, TM; Lun, JH; Netzler, NE; Russo, AG; Tuipulotu, DE; White, PA; Yan, GJH1
Ackermann-Gäumann, R; Engler, O; Grandgirard, D; Leib, SL; Lenz, N1
Choi, BS; Choi, MS; Kim, DE; Kim, HG; Kim, K; Park, CM; Shin, Y; Yoon, CH1
Barrs, VR; Beatty, JA; Bordicchia, M; Carrai, M; Fumian, TM; Holmes, EC; Le, SJ; Martella, V; Pesavento, PA; Russo, AG; Shi, M; Van Brussel, K; White, P1

Other Studies

37 other study(ies) available for cytidine and 2'-c-methylcytidine

ArticleYear
Mechanism of activation of beta-D-2'-deoxy-2'-fluoro-2'-c-methylcytidine and inhibition of hepatitis C virus NS5B RNA polymerase.
    Antimicrobial agents and chemotherapy, 2007, Volume: 51, Issue:2

    Topics: Antiviral Agents; Catalysis; Deoxycytidine; Hepacivirus; Hepatitis C; Humans; Mutation; Phosphorylation; RNA-Dependent RNA Polymerase; RNA, Viral; Structure-Activity Relationship; Viral Nonstructural Proteins; Virus Replication

2007
The mechanism of action of beta-D-2'-deoxy-2'-fluoro-2'-C-methylcytidine involves a second metabolic pathway leading to beta-D-2'-deoxy-2'-fluoro-2'-C-methyluridine 5'-triphosphate, a potent inhibitor of the hepatitis C virus RNA-dependent RNA polymerase.
    Antimicrobial agents and chemotherapy, 2008, Volume: 52, Issue:2

    Topics: Antiviral Agents; Cell Line; Cytidine; Deoxycytidine; Hepacivirus; Humans; Microbial Sensitivity Tests; Phosphorylation; Replicon; RNA-Dependent RNA Polymerase; Structure-Activity Relationship; Uridine Triphosphate

2008
Synthesis of 3'-beta-carbamoylmethylcytidine (CAMC) and its derivatives as potential antitumor agents.
    Organic & biomolecular chemistry, 2006, Apr-07, Volume: 4, Issue:7

    Topics: Antineoplastic Agents; Carbamates; Cell Division; Cytidine; Indicators and Reagents; Magnetic Resonance Spectroscopy; Models, Molecular; Molecular Conformation

2006
In vitro selected Con1 subgenomic replicons resistant to 2'-C-methyl-cytidine or to R1479 show lack of cross resistance.
    Virology, 2006, Aug-01, Volume: 351, Issue:2

    Topics: Antiviral Agents; Cell Line; Cytidine; Drug Resistance, Viral; Genome, Viral; Hepacivirus; Humans; Interferon-alpha; Molecular Structure; RNA, Viral; Virus Replication

2006
General catalytic deficiency of hepatitis C virus RNA polymerase with an S282T mutation and mutually exclusive resistance towards 2'-modified nucleotide analogues.
    Antimicrobial agents and chemotherapy, 2006, Volume: 50, Issue:12

    Topics: Binding Sites; Cytidine; Drug Resistance, Viral; Hepacivirus; Humans; Kinetics; Models, Molecular; Mutation; Nucleotides; RNA-Dependent RNA Polymerase; RNA, Viral

2006
Ribavirin antagonizes the in vitro anti-hepatitis C virus activity of 2'-C-methylcytidine, the active component of valopicitabine.
    Antimicrobial agents and chemotherapy, 2006, Volume: 50, Issue:10

    Topics: Antiviral Agents; Cell Line, Tumor; Cytidine; Drug Antagonism; Drug Therapy, Combination; Hepacivirus; Humans; Ribavirin; Virus Replication

2006
2'-C-methylcytidine as a potent and selective inhibitor of the replication of foot-and-mouth disease virus.
    Antiviral research, 2007, Volume: 73, Issue:3

    Topics: Animals; Antiviral Agents; Cricetinae; Cytidine; Enterovirus B, Human; Foot-and-Mouth Disease; Foot-and-Mouth Disease Virus; Reverse Transcriptase Polymerase Chain Reaction; RNA, Viral; Swine; Swine Vesicular Disease; Virus Replication

2007
Synthesis and pharmacokinetics of valopicitabine (NM283), an efficient prodrug of the potent anti-HCV agent 2'-C-methylcytidine.
    Journal of medicinal chemistry, 2006, Nov-02, Volume: 49, Issue:22

    Topics: Animals; Antiviral Agents; Biological Availability; Chemical Phenomena; Chemistry, Physical; Chromatography, High Pressure Liquid; Cytidine; Cytosol; Hepacivirus; Humans; Liver; Magnetic Resonance Spectroscopy; Prodrugs; Protein Binding; Pyrimidine Nucleosides; Rats; Rats, Sprague-Dawley; Solubility

2006
Pyrophosphorolytic excision of nonobligate chain terminators by hepatitis C virus NS5B polymerase.
    Antimicrobial agents and chemotherapy, 2007, Volume: 51, Issue:8

    Topics: Cytidine; Deoxycytosine Nucleotides; Diphosphates; Hepacivirus; Humans; RNA-Dependent RNA Polymerase; RNA, Viral; Viral Nonstructural Proteins

2007
Combinations of 2'-C-methylcytidine analogues with interferon-alpha2b and triple combination with ribavirin in the hepatitis C virus replicon system.
    Antiviral chemistry & chemotherapy, 2008, Volume: 19, Issue:1

    Topics: Antiviral Agents; Cells, Cultured; Computer Simulation; Cytidine; Deoxycytidine; Drug Synergism; Drug Therapy, Combination; Hepacivirus; Humans; Interferon alpha-2; Interferon-alpha; Models, Chemical; Monte Carlo Method; Polymerase Chain Reaction; Recombinant Proteins; Replicon; Ribavirin; RNA, Ribosomal; RNA, Viral

2008
Potential for hepatitis C virus resistance to nitazoxanide or tizoxanide.
    Antimicrobial agents and chemotherapy, 2008, Volume: 52, Issue:11

    Topics: Antiviral Agents; Cell Line; Cytidine; Drug Resistance, Viral; Hepacivirus; Hepatitis C, Chronic; Humans; Interferon alpha-2; Interferon-alpha; Nitro Compounds; Recombinant Proteins; Replicon; Ribavirin; Thiazoles; Virus Replication

2008
Synthesis and evaluation of novel phosphoramidate prodrugs of 2'-methyl cytidine as inhibitors of hepatitis C virus NS5B polymerase.
    Bioorganic & medicinal chemistry letters, 2009, Mar-01, Volume: 19, Issue:5

    Topics: Amides; Animals; Cells, Cultured; Cytidine; Dogs; Drug Evaluation, Preclinical; Hepacivirus; Hepatocytes; Humans; Phosphoric Acids; Prodrugs; Rabbits; Rats; RNA-Dependent RNA Polymerase; Viral Nonstructural Proteins

2009
Cyclic phosphoramidates as prodrugs of 2'-C-methylcytidine.
    European journal of medicinal chemistry, 2009, Volume: 44, Issue:9

    Topics: Animals; Antiviral Agents; Cricetinae; Cytidine; Drug Stability; Hepacivirus; Hepatitis C; Hepatocytes; Humans; Prodrugs; Structure-Activity Relationship

2009
Phosphoramidate prodrugs of 2'-C-methylcytidine for therapy of hepatitis C virus infection.
    Journal of medicinal chemistry, 2009, Sep-10, Volume: 52, Issue:17

    Topics: Amides; Animals; Antiviral Agents; Cell Line; Cytidine; Hepacivirus; Hepatitis C; Hepatocytes; Humans; Phosphoric Acids; Polyphosphates; Prodrugs; Structure-Activity Relationship; Virus Replication

2009
Evaluation of the role of three candidate human kinases in the conversion of the hepatitis C virus inhibitor 2'-C-methyl-cytidine to its 5'-monophosphate metabolite.
    Antiviral research, 2010, Volume: 85, Issue:3

    Topics: Antiviral Agents; Biotransformation; Cell Line; Cytidine; Cytidine Monophosphate; Deoxycytidine Kinase; Gene Silencing; Hepacivirus; Humans; Prodrugs; RNA, Small Interfering; Uridine Kinase

2010
Efficacy of 2'-C-methylcytidine against yellow fever virus in cell culture and in a hamster model.
    Antiviral research, 2010, Volume: 86, Issue:3

    Topics: Alanine Transaminase; Animals; Antiviral Agents; Aspartate Aminotransferases; Body Weight; Chlorocebus aethiops; Cricetinae; Cytidine; Female; Liver; Mesocricetus; Survival Analysis; Treatment Outcome; Vero Cells; Viral Load; Yellow Fever; Yellow fever virus

2010
Enhancement of intestinal absorption of 2-methyl cytidine prodrugs.
    Drug delivery, 2010, Volume: 17, Issue:4

    Topics: Animals; Caco-2 Cells; Cytidine; Drug Synergism; Humans; Intestinal Absorption; Male; Mice; Mice, Knockout; Prodrugs; Rats; Rats, Sprague-Dawley

2010
Antiviral efficacy upon administration of a HepDirect prodrug of 2'-C-methylcytidine to hepatitis C virus-infected chimpanzees.
    Antimicrobial agents and chemotherapy, 2011, Volume: 55, Issue:8

    Topics: Animals; Antiviral Agents; Cytidine; Cytidine Monophosphate; Female; Hepacivirus; Hepatitis C; Hepatocytes; Macaca mulatta; Male; Pan troglodytes; Prodrugs; Pyrimidine Nucleosides; Rats; Rats, Sprague-Dawley; Viral Load

2011
San-Huang-Xie-Xin-Tang extract suppresses hepatitis C virus replication and virus-induced cyclooxygenase-2 expression.
    Journal of viral hepatitis, 2011, Volume: 18, Issue:7

    Topics: Antiviral Agents; Catechin; Cell Line; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cytidine; Drug Therapy, Combination; Drugs, Chinese Herbal; Hepacivirus; Humans; Interferon-alpha; NF-kappa B; Oligopeptides; Signal Transduction; Viral Nonstructural Proteins; Virus Replication

2011
Inhibition of norovirus replication by the nucleoside analogue 2'-C-methylcytidine.
    Biochemical and biophysical research communications, 2012, Nov-02, Volume: 427, Issue:4

    Topics: Animals; Antiviral Agents; Cell Line; Cytidine; Drug Resistance, Viral; Mice; Norovirus; Ribavirin; Virus Replication

2012
Proof of concept for the inhibition of foot-and-mouth disease virus replication by the anti-viral drug 2'-C-methylcytidine in severe combined immunodeficient mice.
    Transboundary and emerging diseases, 2014, Volume: 61, Issue:6

    Topics: Animals; Antiviral Agents; Cytidine; Disease Models, Animal; Foot-and-Mouth Disease; Foot-and-Mouth Disease Virus; Mice; Mice, SCID; RNA, Viral

2014
The viral polymerase inhibitor 2'-C-methylcytidine inhibits Norwalk virus replication and protects against norovirus-induced diarrhea and mortality in a mouse model.
    Journal of virology, 2013, Volume: 87, Issue:21

    Topics: Animal Structures; Animals; Antiviral Agents; Body Weight; Caliciviridae Infections; Cytidine; Diarrhea; Disease Models, Animal; Feces; Female; Male; Mice; Norovirus; Norwalk virus; RNA, Viral; Survival Analysis; Viral Load; Virus Replication

2013
Sensitivity of a ribavirin resistant mutant of hepatitis C virus to other antiviral drugs.
    PloS one, 2013, Volume: 8, Issue:9

    Topics: Amino Acid Substitution; Antiviral Agents; Cell Line; Cytidine; Drug Resistance, Viral; Fluorouracil; Hepacivirus; Hepatitis C, Chronic; Humans; Kinetics; Microbial Sensitivity Tests; Mutation; Ribavirin; Viral Proteins; Virus Replication

2013
In vitro surrogate models to aid in the development of antivirals for the containment of foot-and-mouth disease outbreaks.
    Antiviral research, 2014, Volume: 105

    Topics: Animals; Antiviral Agents; Aphthovirus; Benzimidazoles; Cattle; Cell Line; Chlorocebus aethiops; Cytidine; Cytopathogenic Effect, Viral; Drug Discovery; Foot-and-Mouth Disease; Models, Theoretical; Oximes; Ribavirin; RNA, Viral; Sulfonamides; Virus Cultivation; Virus Replication

2014
Inhibitors of the tick-borne, hemorrhagic fever-associated flaviviruses.
    Antimicrobial agents and chemotherapy, 2014, Volume: 58, Issue:6

    Topics: Amino Acid Substitution; Antiviral Agents; Cell Line; Cytidine; Cytopathogenic Effect, Viral; Drug Resistance, Viral; Flavivirus; Hemorrhagic Fevers, Viral; Humans; Models, Molecular; Mutation; Tick-Borne Diseases; Virus Replication

2014
The enterovirus protease inhibitor rupintrivir exerts cross-genotypic anti-norovirus activity and clears cells from the norovirus replicon.
    Antimicrobial agents and chemotherapy, 2014, Volume: 58, Issue:8

    Topics: Amides; Antiviral Agents; Cell Line; Cysteine Endopeptidases; Cytidine; Drug Combinations; Drug Synergism; Hepatocytes; Humans; Isoxazoles; Molecular Docking Simulation; Norwalk virus; Papain; Phenylalanine; Pyrazines; Pyrrolidinones; Replicon; RNA-Dependent RNA Polymerase; Valine; Viral Proteins; Virus Replication

2014
Prophylactic treatment with the nucleoside analogue 2'-C-methylcytidine completely prevents transmission of norovirus.
    The Journal of antimicrobial chemotherapy, 2015, Volume: 70, Issue:1

    Topics: Animals; Antiviral Agents; Caliciviridae Infections; Chemoprevention; Cytidine; Diarrhea; Disease Models, Animal; Female; Male; Mice; Norovirus; Survival Analysis

2015
Characterization of the activity of 2'-C-methylcytidine against dengue virus replication.
    Antiviral research, 2015, Volume: 116

    Topics: Animals; Antiviral Agents; Biological Assay; Chlorocebus aethiops; Cytidine; Dengue; Dengue Virus; Disease Models, Animal; Mice; Replicon; RNA, Viral; Transplantation, Heterologous; Vero Cells; Virus Replication

2015
Nucleoside inhibitors of tick-borne encephalitis virus.
    Antimicrobial agents and chemotherapy, 2015, Volume: 59, Issue:9

    Topics: Adenosine; Animals; Antiviral Agents; Cell Line; Cytidine; Encephalitis Viruses, Tick-Borne; Humans; Nucleosides; Swine; Tubercidin; Virus Replication

2015
Biochemical Evaluation of the Inhibition Properties of Favipiravir and 2'-C-Methyl-Cytidine Triphosphates against Human and Mouse Norovirus RNA Polymerases.
    Antimicrobial agents and chemotherapy, 2015, Volume: 59, Issue:12

    Topics: Amides; Animals; Antiviral Agents; Cell Line, Tumor; Cytidine; DNA-Directed RNA Polymerases; Escherichia coli; Gene Expression Regulation, Viral; Hepatocytes; Host Specificity; Humans; Kinetics; Mice; Norovirus; Pyrazines; Recombinant Proteins; Ribonucleotides; Transcription, Genetic; Viral Proteins; Virus Replication

2015
Treatment with a Nucleoside Polymerase Inhibitor Reduces Shedding of Murine Norovirus in Stool to Undetectable Levels without Emergence of Drug-Resistant Variants.
    Antimicrobial agents and chemotherapy, 2015, Dec-28, Volume: 60, Issue:3

    Topics: Amides; Animals; Caliciviridae Infections; Cytidine; Disease Models, Animal; Feces; Gastroenteritis; Mice; Mice, Knockout; Norovirus; Pyrazines; Receptors, Interferon; Transplant Recipients; Virus Shedding

2015
Anti-Dengue Virus Constituents from Formosan Zoanthid Palythoa mutuki.
    Marine drugs, 2016, Aug-09, Volume: 14, Issue:8

    Topics: Animals; Anthozoa; Antiviral Agents; Carotenoids; Circular Dichroism; Cytidine; Dengue Virus; Ecdysteroids; Inhibitory Concentration 50; Molecular Structure; Nuclear Magnetic Resonance, Biomolecular; Principal Component Analysis; Tetrazolium Salts; Thiazoles

2016
Nucleoside analogue 2'-C-methylcytidine inhibits hepatitis E virus replication but antagonizes ribavirin.
    Archives of virology, 2017, Volume: 162, Issue:10

    Topics: Antiviral Agents; Cell Line; Cytidine; Hepatitis E virus; Humans; Ribavirin; Virus Replication

2017
Potential Therapeutic Agents for Feline Calicivirus Infection.
    Viruses, 2018, 08-16, Volume: 10, Issue:8

    Topics: Animals; Antiviral Agents; Caliciviridae Infections; Calicivirus, Feline; Cat Diseases; Cats; Cell Line; Cytidine; DNA-Directed RNA Polymerases; Epithelial Cells; Flavones; Gene Expression; High-Throughput Screening Assays; Inhibitory Concentration 50; Nitro Compounds; Peptide Hydrolases; Polyproteins; Pyridoxal Phosphate; Recombinant Proteins; Respiratory Tract Infections; Sulfonic Acids; Thiazoles

2018
Evaluation of antivirals against tick-borne encephalitis virus in organotypic brain slices of rat cerebellum.
    PloS one, 2018, Volume: 13, Issue:10

    Topics: Adenosine; Animals; Antiviral Agents; Cell Line; Cerebellum; Cytidine; Encephalitis Viruses, Tick-Borne; Epithelial Cells; Humans; Kidney; Microtomy; Rats; Rats, Wistar; Swine; Tubercidin; Viral Load; Virus Replication

2018
Identification of novel compounds against Tat-mediated human immunodeficiency virus-1 transcription by high-throughput functional screening assay.
    Biochemical and biophysical research communications, 2020, 03-05, Volume: 523, Issue:2

    Topics: 3-Deazauridine; Anti-HIV Agents; Cell Line; Cytidine; Deoxycytidine; Drug Repositioning; Gemcitabine; High-Throughput Screening Assays; HIV-1; Humans; Roscovitine; Small Molecule Libraries; tat Gene Products, Human Immunodeficiency Virus; Transcription, Genetic; Virus Replication

2020
Feline Calicivirus Virulent Systemic Disease: Clinical Epidemiology, Analysis of Viral Isolates and In Vitro Efficacy of Novel Antivirals in Australian Outbreaks.
    Viruses, 2021, 10-09, Volume: 13, Issue:10

    Topics: Animals; Antiviral Agents; Australia; Caliciviridae Infections; Calicivirus, Feline; Capsid; Cat Diseases; Cats; Cytidine; Disease Outbreaks; Female; Male; Metagenome; Nitro Compounds; Phylogeny; Thiazoles

2021