cytellin and ursane

cytellin has been researched along with ursane* in 2 studies

Other Studies

2 other study(ies) available for cytellin and ursane

Article	Year
New triterpenic acids produced in callus culture from fruit pulp of Acca sellowiana (O. Berg) Burret. Food research international (Ottawa, Ont.), 2019, Volume: 119 The aim of this work was the study of the best conditions for obtaining a callus culture from the pulp of Acca sellowiana, and to perform a quali-quantitative analysis of the secondary metabolites yielded by the in vitro callus culture. To this end, callus was induced on both Murashige and Skoog and Gamborg B5 media containing various combinations of growth regulators. Three previously undescribed ursane-type triterpenoids, 2α,3β,6α,23-tetrahydroxy-18α,19α-urs-20-en-28-oic acid, 2α,3β,23-trihydroxy-18α,19α-urs-20-en-28-oic acid and 2α,3β,6β,23-tetrahydroxy-18α,19α-urs-20-en-28-oic acid were isolated from the methanolic extract of A. sellowiana culture and characterized by 1D and 2D NMR experiments. Moreover, the quali-quantitative analysis (ESI-MS Topics: Fruit; Gas Chromatography-Mass Spectrometry; Myrtaceae; Oleanolic Acid; Phlorhizin; Phytochemicals; Plant Extracts; Secondary Metabolism; Sitosterols; Triterpenes; Ursolic Acid	2019
Seco-ursane-type Triterpenoids from Salvia urmiensis with Apoptosis-inducing Activity. Planta medica, 2015, Volume: 81, Issue:14 Fractionation of an acetone extract of the aerial parts of Salvia urmiensis led to the isolation of a new (1) and a known (2) E-seco-ursane-type triterpenoid, together with four other known compounds. Their structures were established by 1D and 2D nuclear magnetic resonance as well as high-resolution electrospray ionization mass spectrometry. The effect of compounds 1 and 2 on cell viability of HeLa and HepG2 cells was investigated with the MTT assay. We also report the mechanism of action of compound 2 as a potential anticancer agent in HeLa cells. Bcl-2, Bax, and caspases signaling pathway expression in HeLa cells was analyzed. HeLa cells treated with compound 2 were assayed for the cleavage of poly-(ADP-ribose)-polymerase and DNA fragmentation resulting in nuclear shrinkage. Taken together, these results suggest that treatment of HeLa cells with compound 2 can induce apoptosis by regulating Bcl-2 family members and by suppressing caspase cascade activation. Topics: Antineoplastic Agents, Phytogenic; Apigenin; Apoptosis; bcl-2-Associated X Protein; Caspases; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; HeLa Cells; Hep G2 Cells; Humans; Magnetic Resonance Spectroscopy; Molecular Structure; Oleanolic Acid; Proto-Oncogene Proteins c-bcl-2; Salvia; Sitosterols; Triterpenes	2015

Article

Year

New triterpenic acids produced in callus culture from fruit pulp of Acca sellowiana (O. Berg) Burret.

Food research international (Ottawa, Ont.), 2019, Volume: 119

The aim of this work was the study of the best conditions for obtaining a callus culture from the pulp of Acca sellowiana, and to perform a quali-quantitative analysis of the secondary metabolites yielded by the in vitro callus culture. To this end, callus was induced on both Murashige and Skoog and Gamborg B5 media containing various combinations of growth regulators. Three previously undescribed ursane-type triterpenoids, 2α,3β,6α,23-tetrahydroxy-18α,19α-urs-20-en-28-oic acid, 2α,3β,23-trihydroxy-18α,19α-urs-20-en-28-oic acid and 2α,3β,6β,23-tetrahydroxy-18α,19α-urs-20-en-28-oic acid were isolated from the methanolic extract of A. sellowiana culture and characterized by 1D and 2D NMR experiments. Moreover, the quali-quantitative analysis (ESI-MS

Topics: Fruit; Gas Chromatography-Mass Spectrometry; Myrtaceae; Oleanolic Acid; Phlorhizin; Phytochemicals; Plant Extracts; Secondary Metabolism; Sitosterols; Triterpenes; Ursolic Acid

2019

Seco-ursane-type Triterpenoids from Salvia urmiensis with Apoptosis-inducing Activity.

Planta medica, 2015, Volume: 81, Issue:14

Fractionation of an acetone extract of the aerial parts of Salvia urmiensis led to the isolation of a new (1) and a known (2) E-seco-ursane-type triterpenoid, together with four other known compounds. Their structures were established by 1D and 2D nuclear magnetic resonance as well as high-resolution electrospray ionization mass spectrometry. The effect of compounds 1 and 2 on cell viability of HeLa and HepG2 cells was investigated with the MTT assay. We also report the mechanism of action of compound 2 as a potential anticancer agent in HeLa cells. Bcl-2, Bax, and caspases signaling pathway expression in HeLa cells was analyzed. HeLa cells treated with compound 2 were assayed for the cleavage of poly-(ADP-ribose)-polymerase and DNA fragmentation resulting in nuclear shrinkage. Taken together, these results suggest that treatment of HeLa cells with compound 2 can induce apoptosis by regulating Bcl-2 family members and by suppressing caspase cascade activation.

Topics: Antineoplastic Agents, Phytogenic; Apigenin; Apoptosis; bcl-2-Associated X Protein; Caspases; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; HeLa Cells; Hep G2 Cells; Humans; Magnetic Resonance Spectroscopy; Molecular Structure; Oleanolic Acid; Proto-Oncogene Proteins c-bcl-2; Salvia; Sitosterols; Triterpenes

2015