cytellin and taraxerol

A phytochemical study of Ficus thonningii has led to the isolation of two previously unreported compounds, thonningiiflavanonol A and thonningiiflavanonol B together with 16 known compounds: shuterin, naringenin, syringic acid, p-hydroxybenzoic acid, genistein, 5,7,3',4',5'-pentahydroxyflavanone, luteolin, methylparaben, aromadendrin, garbanzol, dihydroquercetin, 5,7,3'-trihydroxyflavanone, β-sitosterol, sitosterolglucoside, lupeol acetate, and taraxerol. Their structures were elucidated on the basis of spectroscopic data. The new compounds and extracts displayed potent antioxidant activity.

Topics: Antioxidants; Ficus; Flavanones; Flavonoids; Gallic Acid; Genistein; Luteolin; Magnetic Resonance Spectroscopy; Molecular Structure; Oleanolic Acid; Parabens; Plant Bark; Plant Extracts; Plant Roots; Plant Stems; Quercetin; Sitosterols

To investigate the chemical constituents of the leaves of Clerodendrum trichotomum.. The chemical constituents of petroleum ether extract of the leaves of Clerodendrum trichotomum were isolated and purified by various chromatographic techniques, such as silica gel, ODS, Sephadex LH-20, semi-preparative HPLC and recrystallization. The structures of these isolated compounds were identified by spectroscopic analysis (1 H-NMR,13 C-NMR,2D-NMR and MS).. Ten compounds were isolated and identified from petroleum ether extract, containing four triterpenes, lupeol(1), friedelin(2), betulinic acid(3) and taraxerol(4); four sterols, 22-dehydroclerosterol(5), clerosterol(6), stigmasterol(7) and sitosterol(8); one diterpenoid, transphytol(9), and one alkaloid, 1H-indole-3-carboxylic acid(10).. Compound 10 is obtained from the genus Clerodendrum for the first time, and seven compounds (1,3-4, and 7-10) are firstly isolated from this plant.

Topics: Betulinic Acid; Clerodendrum; Indoles; Oleanolic Acid; Pentacyclic Triterpenes; Plant Leaves; Sitosterols; Sterols; Stigmasterol; Triterpenes

To study the chemical constituents from root bark of Discocleidion rufescens.. Column chromatography and spectral analysis were used to isolate and identify the constituents.. Ten compounds were obtained and identified from root bark of Discocleidion rufescens including beta-sitosterol (I), scopoletin (II), daucosterol (III), ricinine (IV), chrysophanol (V), aphyscion (VI), taraxerol (VII), pigenin (VIII), luteolin (IX), gallic acid (X).. Ten compounds are isolated for the first time from root bark of Discocleidion rufescens. The monomer of Compounds II is isolated from this genus for the first time.

Topics: Alkaloids; Anthraquinones; Euphorbiaceae; Gallic Acid; Luteolin; Molecular Structure; Oleanolic Acid; Plant Bark; Plant Roots; Pyridones; Scopoletin; Sitosterols; Spectrophotometry, Infrared

Bioassay-guided fractionation of the N-hexane and CHCl₃ phases of the methanol extract of the roots of Conyza canadensis (L.) Cronquist led to the isolation of two new dihydropyranones named conyzapyranone A (1) and B (2), and the known 4 Z,8 Z-matricaria- γ-lactone (3), 4 E,8 Z-matricaria- γ-lactone (4), 9,12,13-trihydroxy-10(E)-octadecenoic acid (5), epifriedelanol (6), friedeline (7), taraxerol (8), simiarenol (9), spinasterol (10), stigmasterol, β-sitosterol, and apigenin. The structures were determined by means of ESIMS and 1D and 2D NMR spectroscopy, including ¹H-¹H COSY, NOESY, HSQC, and HMBC experiments. The isolated compounds were evaluated for their antiproliferative activities and were demonstrated to exert considerable cell growth-inhibitory activity against human cervix adenocarcinoma (HeLa), skin carcinoma (A431), and breast adenocarcinoma (MCF-7) cells. Some of the active components, including 2, 4, and 10, proved to be substantially more potent against these cell lines than against noncancerous human foetal fibroblasts (MRC-5) and can therefore be considered selective antiproliferative natural products.

Topics: Antineoplastic Agents, Phytogenic; Apigenin; Cell Line, Tumor; Chemical Fractionation; Chromatography, High Pressure Liquid; Conyza; Female; Humans; Hydroxy Acids; Magnetic Resonance Spectroscopy; Molecular Structure; Oils, Volatile; Oleanolic Acid; Oleic Acids; Plant Extracts; Plant Roots; Pyrones; Sitosterols; Stigmasterol

To study the chemical constituents of Uvaria microcarpa.. The constituents were repeatedly separated and purified with silica gel column and Sephadex LH-20 column, and identified by physico-chemical properties and spectral methods.. Nine compounds were separated and identified as beta-sitosterol palmitate (I), euphorginol (II), beta-sitosterol (III), benzoic acid(IV), stigmasterol-3-O-beta-D-glucopyranoside (V), taraxerol (VI), emodin (VII), aristololactam A II (VI), beta-daucosterol (IX) .. Compounds I, II, V, V are isolated from this plant for the first time.

Topics: Emodin; Glucosides; Molecular Structure; Oleanolic Acid; Plant Stems; Plants, Medicinal; Sitosterols; Spectrophotometry, Ultraviolet; Stigmasterol; Uvaria

To study the chemical constituents from the aerial part of Euphorbia chrysocoma.. All compounds were isolated and purified by many methods, including siliga gel and reversed phase RP-18 column chromatographies, preparative thin layer chromatography, Sephadex LH-20, and recrystallization. Their structures were mainly elucidated by ESI-MS and NMR spectra and their physical characters.. Six compounds were isolated from the petroleum ether section from 75% ethanol extraction of the material. Their structures were identified as taraxerol (1), epitaraxerol (2), beta-sistosterol (3), beta-sitostenone (4), jolkinolide E (5), and sesamin (6).. Compounds 1, 2, 4, 5, and 6 are isolated from this plant for the first time.

Topics: Dioxoles; Diterpenes; Euphorbia; Lignans; Molecular Structure; Oleanolic Acid; Plant Components, Aerial; Plants, Medicinal; Sitosterols

Two new triterpenoids taraxer-14-ene-1alpha,3beta-diol (1) and 3beta-hydroxytaraxer-14-ene-1-one (2), together with the known triterpenes taraxerol (3), betulin (4), betulinic acid (5), sumaresinolic acid (6), and 5-hydroxy-2-methoxy-1,4-naphthoquinone (7), 5,7-dihydroxy-6,8-dimethylchromone (8), alpha-monpalmitin (9), palmitic acid (10), 6beta-hydroxystigmast-4-en-3-one (11), beta-sitostero1 (12), have been isolated from the petroleum ether fraction of the ethanolic extract of Pterospermum heterophyllum. Their structures were established by spectroscopic methods including IR, MS, 1D, and 2D NMR experiments. Compounds 1-8 were evaluated against several human cancer cell lines. Compound 1 showed in vitro selective cytotoxicity against human lung cancer cell lines (A549) with an IC(50) value of 1.22 microM. Compound 7 showed significant cytotoxicity against the A549, HCT-8, Bel7402, BGC-823, and A2780 cancer cell lines with IC(50) values of 0.21, 0.55, 0.40, 0.59, and 0.34 microM, respectively. However, the other compounds were inactive (IC(50)>10 microM).

Topics: Antineoplastic Agents, Phytogenic; Betulinic Acid; Drug Screening Assays, Antitumor; Drugs, Chinese Herbal; Female; Humans; Malvaceae; Molecular Structure; Nuclear Magnetic Resonance, Biomolecular; Oleanolic Acid; Palmitic Acid; Pentacyclic Triterpenes; Plant Roots; Sitosterols; Stereoisomerism; Terpenes; Triterpenes

To study the chemical constituents of Excoecaria agallocha L.. The constituents were isolated and purified by repeated column chromatography and their structures were elucidated by spectroscopic analysis.. Six triterpenoids including taraxerone (1), beta-amyrin acetate (2), 3beta-[(2E,4E)-6-oxo-decadienoyloxy]-olean-12-ene (3), taraxerol (4), acetylaleuritolic acid (5), and cycloart-22-ene-3beta, 25-diol (6), and three steroids including beta-sitostenone (7), (24R)-24-ethylcholesta-4,22-dien-3-one (8), and beta-sitosterol (9) were isolated and identified from the stems and twigs of the mangrove plant E. agallocha.. Compounds 5-8 were isolated from E. agallocha for the first time.

Topics: Euphorbiaceae; Magnetic Resonance Spectroscopy; Oleanolic Acid; Sitosterols; Steroids; Triterpenes

To study the chemical constituents from the roots of Pterospermum heterophyllum.. The chemical constituents of P. heterophyllum were isolated and purified by silica gel and sephadex LH-20 column chromatography. Their structures were identified on the basis of spectroscopic data and physicochemical properties.. Nine compounds were isolated and identified as taraxerol (1), betulin (2), betulinic acid (3), sumaresinolic acid (4), 2-methoxy-5-hydroxy-1, 4-naphthoquinone (5), 5, 7-dihydroxy-6, 8-dimethylchromone (6), alpha-monpalmitin (7), palmitic acid (8), beta-sitosterol (9).. Compounds 2-7 were isolated from this genus for the first time.

Topics: Betulinic Acid; Chromatography; Malvaceae; Naphthoquinones; Oleanolic Acid; Palmitic Acid; Pentacyclic Triterpenes; Plant Roots; Sitosterols; Triterpenes

7 compounds were isolated from the ethyl-acetate extract of Vaccinium iteophyllum Hance by using repeated silical gel column chromatography. These 7 compounds were identified by means of physico-chemical propertic and spectroscopic analysis as beta-sitosterol (I), ursolic acid (II), taraxerol (III), taraxerone (IV), friedelin (V), friedelinol (VI), 19,24-dihydroxyurs-12-en-3-one-28-oic acid (VII). The chemical constituents from this plant were reported here for the first time.

Topics: Acetates; Drugs, Chinese Herbal; Oleanolic Acid; Plant Leaves; Plant Stems; Plants, Medicinal; Sitosterols; Triterpenes; Vaccinium

Twelve compounds were isolated from the EtOAc-soluble and ButOH-soluble portions of the EtOH extract from the bark of Mitragyna rotundifolia. These compounds were identified by their spectral data as dauricine (1), 3,4-dihydroxybezoic acid (2), beta-sitosterol (3), scopleton (4),3,4,5-trimethyoxyphenol-1-glucopyranoside (5), taraxerol (6), 4-hydroxy-3-methyloxybenzoic acid (7), 3-hydroxy-4-methyloxybenzoic acid (8), caffeic acid (9), gambirine (10), gambireine (11),1,1-dimetheyl-2-acetl-diethyl ether (12), respectively. All compounds were isolated from this genus for the first time.

Topics: Alkaloids; Caffeic Acids; Mitragyna; Oleanolic Acid; Plant Bark; Plants, Medicinal; Sitosterols; Spectrophotometry, Ultraviolet

The compounds from the root of Rhododendron molle G. Don were isolated, purified by various chromatographic techniques, and their structures were identified according to the physical and chemical features and spectral data. Three compounds were separated from the root of Rhododendron molle G. Don and identified as Rhodojaponin-III, taraxerol, beta-sitosterol for the first time.

Topics: Diterpenes; Drugs, Chinese Herbal; Oleanolic Acid; Plant Roots; Rhododendron; Sitosterols

To study the constituents from Clerodendrum bungei.. The constituents were isolated and purified with chromatographic methods, and identified by NMR, MS and IR.. Five compounds were isolated, beta-sitosterol (1), taraxerol (2), glochidone (3), glochidonol (4), glochidiol (5).. Compounds (3), (4) and (5) were isolated for the first time from C. bungei.

Topics: Clerodendrum; Oleanolic Acid; Plant Roots; Plants, Medicinal; Sitosterols

To study the chemical constituents from Uvaria macrophylla Roxb. (Annonaceae).. Various chromatography techniques were used to separate and purify the constituents. Their structures were elucidated by UV, IR, MS, 1HNMR, 13CNMR, 1H-1H COSY, HMQC and HMBC spectral analysis.. Seven compounds have been isolated from the CHCl3 extract of the roots of the U. macrophylla. They were identified as macrophyllin (1), onysilin (2), taraxerol (3), 3,5-dimethoxy benzyl benzoic acid ester (4), benzoic acid (5), beta-sitosterol (6) and daucosterol (7).. Compound 1 is a new compound. Compounds 2-7 were obtained from this plant for the first time.

Topics: Flavonoids; Molecular Structure; Oleanolic Acid; Plant Roots; Plants, Medicinal; Sitosterols; Uvaria

To investigate the chemical constituents of Tetrastigma hemsleyanum native to China.. Compounds were separated by column chronatography with silica gel and elucidated by chemical evidence and spectral analysis.. Four compounds were isolated from the petroleum ether extract. Their structures were identifies as taraxerone, taraxerol,beta-sitosterol and ergosterol.. These compounds were isolated from the plant for the first time.

Topics: Ergosterol; Oleanolic Acid; Plants, Medicinal; Sitosterols; Vitaceae

Eleven crystalline constituents have been isolated from the leaves of Mangifera persiciformis, of which five were identified as taraxerol, friedelin, beta-sitosterol, mangiferin and quercetin by comparing their physicochemical and spectroscopic data. They were isolated from this plant for the first time.

Topics: Antiviral Agents; Drugs, Chinese Herbal; Oleanolic Acid; Plant Leaves; Plants, Medicinal; Sitosterols; Xanthenes; Xanthones