cytellin and syringin

Topics: Anticholesteremic Agents; Antioxidants; Ascorbic Acid; Carotenoids; Cell Line, Tumor; Cell Survival; Cytotoxins; Enzyme Inhibitors; Fatty Acids; Glucosides; Humans; Phenylpropionates; Phytochemicals; Phytosterols; Plant Extracts; Polyphenols; Receptors, LDL; Riboflavin; Saponins; Sitosterols; Urticaceae

To study the chemical constituents from the leaves of "Chuju" Chrysanthemum morifolium.. All compounds were separated and purified by column chromatography over silica gel, Sephadex LH-20 and preparative HPLC. Their structures were identified by spectral methods including 1H-NMR and 13C-NMR.. 21 compounds were isolated and identified as octa-cosyl alcohol (1), β-sitosterol (2), lupeol (3), α-amyrin (4), daucosterol (5), ineupatorolide B (6), syringin (7), chlorogenic acid (8), petasiphenol (9), physcion (10), acacetin (11), eupatilin (12), quercetin (13), diosmetin (14), luteolin (15), apigenin (16), apigenin- 7-O-β-D-glucopyranoside (17), quercetin-3-O-β-D-glucopyranoside (18), luteolin-7-O-β-D-gluco pyranoside (19), apigenin-7-O-β-D- neospheroside (20), and acacetin-7-O-β-D-glucoside (21).. Compounds 1-12, 18 and 20 are isolated from this plant for the first time. Compounds 10, 13, 14, 15 and 16 have shown strong antioxidant activities by DPPH · scavenging activity better than Vit C.

Topics: Antioxidants; Apigenin; Chlorogenic Acid; Chrysanthemum; Flavones; Flavonoids; Glucosides; Luteolin; Phenylpropionates; Phytochemicals; Plant Leaves; Plants, Medicinal; Quercetin; Sitosterols

Not only neuronal death but also neuritic atrophy and synaptic loss underlie the pathogenesis of Alzheimer's disease as direct causes of the memory deficit. Extracts of Siberian ginseng (the rhizome of Eleutherococcus senticosus) were shown to have protective effects on the regeneration of neurites and the reconstruction of synapses in rat cultured cortical neurons damaged by amyloid β (Aβ)(25-35), and eleutheroside B was one of the active constituents. In this study, a comprehensive evaluation of constituents was conducted to explore active components from Siberian ginseng which can protect against neuritic atrophy induced by Aβ(25-35) in cultured rat cortical neurons. The ethyl acetate, n-butanol and water fractions from the methanol extract of Siberian ginseng showed protective effects against Aβ-induced neuritic atrophy. Twelve compounds were isolated from the active fractions and identified. Among them, eleutheroside B, eleutheroside E and isofraxidin showed obvious protective effects against Aβ(25-35)-induced atrophies of axons and dendrites at 1 and 10 μM.

Topics: Amyloid beta-Peptides; Animals; Atrophy; Axons; Benzaldehydes; Cells, Cultured; Cerebral Cortex; Coumarins; Dendrites; Eleutherococcus; Fatty Acids; Female; Glucosides; Lignans; Magnetic Resonance Spectroscopy; Neurites; Neurons; Phenylpropionates; Plant Extracts; Pregnancy; Rats; Rats, Sprague-Dawley; Sitosterols; Spectrometry, Mass, Electrospray Ionization; Stigmasterol

To study the chemical constituents of Exochorda racemosa.. Compounds were isolated and purified by silica gel, Sephadex LH-20, MCI gel and RP-18 column chromatography, and their structures were determined by spectroscopic analysis.. Twenty compounds were isolated and identified as N-p-coumaroyl-N'-caffeoylputrescine (1), sutherlandin trans-p-coumarate (2), apigenin 7-O-methylglucuronide (3), astragalin (4), nicotiflorin (5), kaempferol 3-neohesperidoside (6), rutin (7), apigenin (8), luteolin (9), linalool-1-oic acid (10), betulalbuside A (11), ursolic acid (12) , corosolic acid (13), gynuramide II (14), beta-sitosterol (15), daucosterol (16), uridine (17), adenosine (18), syringin (19), and trans4-hydroxycinnamic acid (20), respectively.. All compounds were obtained from this plant for the first time, moreover, 1 was reported as a new natural product, and 2 is a naturally rare cyanogenic glycoside.

Topics: Apigenin; Flavonoids; Glucosides; Glucuronides; Kaempferols; Luteolin; Magnetic Resonance Spectroscopy; Phenols; Phenylpropionates; Rosaceae; Sitosterols; Triterpenes; Ursolic Acid

To study the chemical constituents from the stems of Acanthopanax gracilistylus.. The chemical constituents of the plant were isolated and puried by column chromatography and their structures were elucidated on the basis of physico-chemical properties and spectral data.. Sixteen compounds were isolated and identified as (2S,3S, 4R, 8E)-2-[(2'R)-2'-hydroxy-pentadecanoylamino]-heptacosane-1,3,4-triol-8-ene(1a),(2S,3S,4R,8E)-2-[(2'R)-2'-hydroxy-octadecanoylamino]-lignocer-ane-1,3,4-triol-8-ene(1b), (2S, 3S, 4R, 8E) -2-[(2'R) -2'-hydroxy-heneicosanoylamino]-heneicosane-1,3,4-triol-8-ene (1c), (2S, 3S,4R, 8E)-2-[(2'R) -2'-hydroxy-docosanoylamino] -eicosane-1,3,4-triol-8-ene (1d), (2S, 3S, 4R, 8E)-2-[(2'R)-2'-hydroxy-trico-sanoylamino]-nonadecane-1,3,4-triol-8-ene (1e), (2S,3S,4R,8E)-2-[(2'R)-2'-hydroxy-lignocera-noylamino]-cctadecane-1,3,4-tri-ol-8-ene(1f), 1-O-beta-D-glucopyranosyl-(2S, 3S, 4R, 8E)-2-[(2'R)-2'-hydroxy-pentadecanoylamino]-nonadecane-1, 3, 4-triol-8-ene (2), 16alpha-hydroxy-ent-kauran-19-ocid (3), 16alphaH, 17-isovaleryloxy-ent-kauran-19-oic acid (4), coniferin (5), syringin (6), eleutheroside D (7), stigmasterol (8), beta-sitosterol (9), daucosterol (10), pentacosanoic acid (11).. Compounds 1a - f, 2 are isolated from this genus for the first time, and compounds 4, 5, 11 are firstly obtained from Acanthopanax gracilistylus.

Topics: Cinnamates; Eleutherococcus; Glucosides; Magnetic Resonance Spectroscopy; Molecular Structure; Phenylpropionates; Plant Extracts; Plant Stems; Plants, Medicinal; Sitosterols; Stigmasterol

To investigate the chemical constituents of the aerial parts of Ammopiptanthus mongolicus.. The chemical constituents were isolated by various column chromatographic methods. The structures were identified by spectral data.. Ten compounds were isolated and identified as m-hydroxybenzoic acid (1), 1-(4-hydroxyphenyl) ethanone (2), beta-sitosterol (3), (-)-syringaresinol (4), (+)-lariciresinol (5), blumenol A (6), blumenol B (7), beta-daucosterol (8), coniferin (9), syringin (10).. The ten compounds were obtained from the genus Ammopiptanthus for the first time.

Topics: Cinnamates; Cyclohexanones; Drugs, Chinese Herbal; Fabaceae; Glucosides; Magnetic Resonance Spectroscopy; Phenylpropionates; Plant Components, Aerial; Sitosterols

Five constituents were isolated from the stems of Oplopanax elatus. They were identified as syringin, daucosterol, beta-sitosterol, L-rhamnose and surcose.

Topics: Drugs, Chinese Herbal; Glucosides; Phenylpropionates; Rhamnose; Sitosterols

Topics: Drugs, Chinese Herbal; Glucosides; Phenylpropionates; Sitosterols

Experiments were carried out on mice and the subjects irradiated for cancer therapy to evaluate the protective efficacy of a Chinese medicinal herb-compound (CMHC). The lethality and the degree of leucopenia caused by radiation in mice medicated with CMHC were significantly less in comparison with control mice (p less than 0.01 and p less than 0.001, respectively). CMHC significantly improved the WBC and the thrombocytes in irradiated workers (p less than 0.01 and p less than 0.001, respectively). The WBC count of 40 patients under radiotherapy while treated with CMHC recovered from 3450 +/- 77/c.mm to 5425 +/- 264/c.mm (p less than 0.001); whereas, in the control group, without any medication, the WBC count dropped significantly (p less than 0.001). Our results revealed the applicabilities of CMHC in protection against radiation damage in spaceflight and in other fields.

Topics: Animals; Asparagine; Drugs, Chinese Herbal; Glucosides; Hemostatics; Humans; Incidence; Leukopenia; Mice; Neoplasms; Phenylpropionates; Radiation Injuries, Experimental; Radiotherapy; Sitosterols