cytellin and sclareol

Phytochemical investigation of n-hexane extract of Salvia sahendica by normal phase column chromatography resulted in the isolation of six compounds. Structures were established by 1D and 2D NMR spectroscopy, and HRMS, as a new norditerpene 1, and known terpenoids, sclareol (2), oleanolic acid (3), β-sitosterol (4), salvigenin (5) and 3α-hydroxy-11α,12α-epoxyoleanan-28,13β-olide (6). The absolute configuration of 1 was confirmed by a combination of X-ray single crystal analysis and electronic circular dichroism spectroscopy. In vitro cytotoxic activity on breast cancer cell line (MDA-MB-231) and also the antimicrobial activity of the pure compounds were tested against Staphylococcus aureus, Bacilus cereus and Escherichia coli.

Topics: Anti-Bacterial Agents; Antineoplastic Agents, Phytogenic; Breast Neoplasms; Cell Line, Tumor; Crystallography, X-Ray; Diterpenes; Female; Flavones; Hexanes; Humans; Magnetic Resonance Spectroscopy; Molecular Structure; Oleanolic Acid; Plant Extracts; Plant Leaves; Salvia; Sitosterols; Staphylococcus aureus

Topics: Diterpenes; Fatty Acids; Mevalonic Acid; Oleanolic Acid; Plants; Sitosterols; Sterols; Terpenes

Topics: Diterpenes; Fatty Acids; Lipid Metabolism; Mevalonic Acid; Sitosterols; Sterols; Terpenes