cytellin and 4-hydroxybenzoic-acid

Insulin secretion and GLUT4 expression are two critical events in glucose regulation. The receptors G-protein-coupled receptor 40 (GPR40) and peroxisome proliferator-activated receptor-gamma (PPAR

Topics: Animals; Cucurbita; Diabetes Mellitus, Experimental; Hypoglycemic Agents; Insulin; Liver Glycogen; Parabens; Plant Extracts; PPAR gamma; RNA, Messenger; Secretagogues; Sitosterols

To study the chemical constituents from Macaranga denticulata Root.. The chemical constituents were isolated and purified by silica-gel column chromatography and recrystallization, and their structures were identified by physicochemical properties and spectral data.. Nine compounds were isolated and identified as: gheddic acid (1), aleuritolic acid-3-acetate (2), β-sitosterol (3), stigmast-4-en-6β-ol-3 -one (4), 2α-hydroxyaleuritolic acid 3-p-hydroxybenzoate (5), scopoletin (6), daucosterol (7), 2, 6-dimethoxy-1,4-benzoquinone (8) and maslinic acid(9).. Compounds 1-9 are obtained from this plant for the first time.

Topics: Benzoquinones; Euphorbiaceae; Parabens; Phytochemicals; Plant Roots; Plants, Medicinal; Scopoletin; Sitosterols; Stigmasterol; Triterpenes

To study the chemical constituents of Asarum himalaicum, fifteen compounds were isolated from a 70% ethanol extract by using a combination of various chromatographic techniques including column chromatography over silica gel, Sephadex LH-20, and semi-preparative HPLC. By spectroscopic techniques including 1H NMR, 13C NMR, and HR-ESI-MS, these compounds were identified as 4-demethoxyaristolochic acid BII (1), aristolochic acid I (2), aristolochic acid Ia (3), 7-hydroxyaristolochic acid I (4), aristolochic acid IV (5), aristolic acid II (6), debilic acid (7), aristololactam I (8), 9-hydroxyaristololactam I (9), 7-methoxyaristololactam IV (10), (2S)-narigenin-5, 7-di-O-beta-D-pyranosylglucoside (11), 4-hydroxybenzoic acid (12), 3, 4-dihydroxybenzoic acid (13), 4-hydroxycinnamic acid (14), and beta-sitosterol (15). All of these compounds (1-15) were obtained from A. himalaicum for the first time. Among them, 1 was identified as a new compound, and compounds 3-6, 9, 12-14 were isolated from Asarum genus for the first time. Since the kidney toxicity of aristolochic acids and aristololactams has been reported, the result of this investigation suggests that it should be cautioned to use A. himalaicum as a medicine.

Topics: Aristolochic Acids; Asarum; Chromatography, High Pressure Liquid; Coumaric Acids; Hydroxybenzoates; Magnetic Resonance Spectroscopy; Molecular Structure; Parabens; Plants, Medicinal; Propionates; Sitosterols; Spectrometry, Mass, Electrospray Ionization

Paniculacin (1), a new coumarin derivative, has been isolated from the ethyl acetate soluble fraction of the ethanolic extract of Murraya paniculata along with umbelliferone, scopoletin, 4-hydroxybenzoic acid, trans-cinnamic acid, and β-sitosterol. Their structures were elucidated on the basis of spectral data.

Topics: Cinnamates; Coumarins; Molecular Structure; Murraya; Nuclear Magnetic Resonance, Biomolecular; Pakistan; Parabens; Scopoletin; Sitosterols

To study the chemical constituent from the antithrombus activity extract of Radix Aerio Fici Microcarpae.. The isolation and purification of the extract were conducted by means of silica gel column chromatography, polyamide column chromatography and recrytallization. The structures of these compounds were elucidated based on the physicochemical properties and spectroscopic analysis.. 7 compounds were isolated from the extract. They were identified as isovanillic acid (1), 4-hydroxybenzoic acid(2),3,4-dihydroxybenzoic acid (3), friedelane (4), alpha-amyrin acetate (5), lanosterol (6) and beta-sitosterol (7) .. Compound 3,4 and 7 are isolated from this plant for the first time.

Topics: Fibrinolytic Agents; Ficus; Hydroxybenzoates; Lanosterol; Molecular Structure; Oleanolic Acid; Parabens; Plant Roots; Sitosterols; Triterpenes; Vanillic Acid

Two new diterpenoids, 14,18-dihydroxyabieta-8,11,13-trien-7-one (1) and 13-acetyl-14,18-dihydroxy-podocarpa-8,11,13-triene (2), together with eight known compounds, i.e., gaultheric acid (3), vanillic acid (4), 4-hydroxybenzoic acid (5), cinnamic acid (6), stearic acid (7), palmitic acid (8), beta-sitosterol (9), and stigmasterol (10), were isolated from the MeOH extract of the whole plant of Gaultheria itoana Hayata (Ericaceae). The structures of the new constituents were elucidated by spectroscopic methods (UV, IR, and 1D- and 2D-NMR) and by mass spectrometry (HR-ESI-MS). Among them, 1 and 2 were demonstrated to exhibit significant cytotoxic activity against the LNCaP cell line.

Topics: Antineoplastic Agents, Phytogenic; Cell Line, Tumor; Cinnamates; Diterpenes; Gaultheria; Humans; Lung Neoplasms; Magnetic Resonance Spectroscopy; Methanol; Molecular Structure; Palmitic Acid; Parabens; Plant Extracts; Sitosterols; Spectrometry, Mass, Electrospray Ionization; Stearic Acids; Stigmasterol; Vanillic Acid

To study the chemical constituents of the fruit of Xylocarpus granatum.. The chemical constituents were isolated by chromatographic methods and their structures were elucidated by NMR spectra and physicochemical properties.. Ten compounds were isolated from the fruit of Xylocarpus granatum and the structures of them were identified as spicatin (1), xyloccensin K(2), 6-acetoxycedrodorin (3), aurantiamide acetate (4), (+)-catechin (5), alpha-tocopherol (6), abscisic acid (7), daucosterol (8), 4-hydroxybenzoic acid (9) and ethyl 3,4-dihydroxybenzoate (10).. Compound 4 -10 are isolated from this plant for the first time.

Topics: Abscisic Acid; alpha-Tocopherol; Catechin; Dipeptides; Ethanol; Fruit; Meliaceae; Parabens; Plants, Medicinal; Sitosterols

To research the chemical constituents from Daphne tangutica.. Column chromatography with silica gel, ODS-C18, Sephadex LH-20 and re-crystallization were employed to isolate and purify the constituents. According to physical and chemical properties and spectral data to identify the structure of compounds.. Eight compounds were isolated and identified as palmitic acid (1), laurostearic acid(2), beta-sitosterol(3), 7-methoxy-8-hydroxycumarin(4), daphnetin(5), genkwanin(6), hydroxygenkwanin(7), p-hydroxybenzoic acid(8).. Compounds 1,2,7 and 8 are isolated from Daphne tangutica for the first time.

Topics: Daphne; Flavones; Flavonoids; Magnetic Resonance Spectroscopy; Palmitic Acid; Parabens; Plant Bark; Plants, Medicinal; Sitosterols

To study the chemical constituents of Litsea lancifolia.. AU compounds were isolated from the diethyl ether extract of the title herb by sillica gel column chromatogrphy, and their structures were identified by physical and chemical evidences and spectral methods.. Seven compounds were isolated and identified as (-)-aristortetralone (1), dehydrodiisoeugenol ( 2), dihydrodehydrodiconifery alcohol ( 3) , 5,7-dimethoxy-3', 4'-methylenedioxyflavan-3-ol (4), p-hydroxy-benzoic acid (5), vanillin(6), p-sitosterol (7), respectively.. All compounds are isolated from this plant for the first time.

Topics: Benzaldehydes; Eugenol; Lignin; Litsea; Parabens; Plant Leaves; Plant Stems; Plants, Medicinal; Sitosterols

To study the chemical constituents of Dendobium crystallinum.. Compounds were isolated and purified by silica gel and Sephadex LH-20 column chromatography. Their structures were identified by physicochemical properties and spectral analyses.. Nine compounds were obtained and identified as: 4, 4'-dihydroxy-3, 5-dimethoxybi-benzyl (1), gigantol (2), naringenin (3) , p-hydroxybenzoic acid (4), n-tetracosyl trans-p-cou-marate (5), n-octacosy trans-p-coumarate (6), n-hexacosyl trans-ferulate (7), stigmasterol (8), daucosterol (9).. All these compounds were obtained from this plant for the first time, compounds 1 and 4 were isolated firstly from the genus.

Topics: Bibenzyls; Chromatography; Dendrobium; Drugs, Chinese Herbal; Flavanones; Guaiacol; Magnetic Resonance Spectroscopy; Parabens; Sitosterols; Stigmasterol

Five compounds were isolated from the fruits of Vitex trifolia and identified on the basis of spectral data and chemical methods to be rho-hydroxybenzoic acid, beta-sitosterol, beta-sitosterol-3-O-glucoside, casticin and, 3,6,7-trimethylquercetagetin. Except beta-sitosterol all of the compounds were obtained from the fruits of the plant for the first time.

Topics: Drugs, Chinese Herbal; Fruit; Parabens; Sitosterols