cytellin and 1-triacontanol

Leishmaniasis is a neglected tropical disease caused by Leishmania parasitic protozoa, which currently lacks efficient treatment. Natural products have shown promise as a potential source for antiprotozoal drugs. This work focuses on the antileishmanial potential of Sassafras albidum (Lauraceae) bark extract. The crude bark extract of S. albidum showed excellent antileishmanial activity with an IC50 value less than 12.5 μg/mL against promastigotes of L. amazonensis. The chloroform stem bark extract of S. albidum was subjected to preparative column chromatography. Five compounds were isolated, purified by recrystallization, and identified as sesamin, spinescin, β-sitosterol, hexatriacontanal, and 1-triacontanol. Antileishmanial and cytotoxic screening were performed on these compounds. Sesamin exhibited the best activity against L. amazonensis with an IC50 of 15.8 μg/mL and was not cytotoxic to mouse macrophage cells (CC50 > 100 μg/mL).

Topics: Dioxoles; Fatty Alcohols; Leishmania; Lignans; Microbial Sensitivity Tests; Plant Extracts; Sassafras; Sitosterols; Trypanocidal Agents

A new lactone was isolated from the leaves of Xylocarpus granatum, along with three known compounds: triacontanol, beta-sitosterol and kaempferol-3-O-beta-D-glucoside. Its structure was elucidated as 3-(1-hydroxyethyl)-4,4-dimethyl-4-butyrolactone (1) by infrared, (1)H and (13)C NMR and ESI-MS data. At a concentration of 20 microg mL(-1), the new lactone gave a 67.4% inhibition rate against wheat powdery mildew.

Topics: Ascomycota; Fatty Alcohols; Fungicides, Industrial; Glucosides; Magnetic Resonance Spectroscopy; Meliaceae; Microbial Sensitivity Tests; Molecular Structure; Mycelium; Plant Diseases; Sitosterols; Spectrometry, Mass, Electrospray Ionization; Spectrophotometry, Infrared; Triticum

To study the chemical constituents of flower buds of Lonicera macranthoides.. The 90% EtOH extract of Lonicera macranthoides. was successively partitioned with petroleum ether and ethyl acetete.. Repeated column chromatography of the ethyl acetete fraction afforded the following compounds (1-9): ginnol (1), triacontanol (2), ursolic acid (3), beta-sitosterol (4), triacontane (5), palmitic acid (6), beta-daucosterol (7), 3-decyl-3-octyldocosan-1-ol (8), 3-dodecyl-3-nonyldocosan-1-ol (9). All compounds except 4 are isolated from this plant for the first time while compounds 2, 3, 5, 8 and 9 are their first time been isolated from genus Lonicera.

Topics: Fatty Alcohols; Flowers; Lonicera; Magnetic Resonance Spectroscopy; Palmitic Acid; Paraffin; Plants, Medicinal; Sitosterols; Triterpenes; Ursolic Acid

An ethyl acetate extract of Oryza sativa (rice) hulls yielded seven compounds: hentriacontane, 1-tetratriacontanol, beta-sitosterol, momilactone A, momilactone B, tricin (a flavonoid), and beta-sitosterol-3-O-beta-D-glucoside. The structures of these compounds were elucidated with 500 MHz nuclear magnetic resonance (NMR), using 1D and 2D spectral methods, aided by electron ionization mass spectrometry (EI-MS), fast atom bombardment mass spectrometry (FAB-MS), infrared (IR), and ultraviolet (UV) spectrophotometry. The complete 1H NMR assignments for momilactone A and B and 13C NMR assignments for tricin are discussed. To the best of our knowledge, hentriacontane, 1-tetratriacontanol, and beta-sitosterol-3-O-beta-D-glucoside were identified for the first time in rice hulls. In biological activity tests using these identified compounds, momilactone A and B showed potent inhibitory activity against duckweed (Lemna paucicostata). 1-Tetratriacontanol and beta-sitosterol-3-O-beta-D-glucoside also showed about 13-20% inhibitory activity based on chlorophyll reduction. Hentriacontane and beta-sitosterol did not show any herbicidal activity. In a germination assay of three weed species (Leptochloa chinenesis L., Amaranthus retroflexus L., and Cyperus difformis L.) in culture tubes both momilactones A and B had high inhibitory effects. Momilactone B completely inhibited germination of all three weed species at 20 ppm. Germination of L. chinensis L. was completely inhibited by a 4 ppm solution of momilactone B.

Topics: Amaranthus; Cyperus; Diterpenes; Fatty Alcohols; Flavonoids; Germination; Herbicides; Hydrocarbons; Lactones; Oryza; Plant Development; Plants; Sitosterols; Spectrum Analysis

From the ethanol extract of Lysimachia pentapetala, six compounds have been isolated. These compounds were identified as triacontanol, beta-sitosterol, glycerol monopalmitate, succinic acid, flavonol glycosides and hitrite upon the date of mp, IR, MS and 1HNMR tests.

Topics: Drugs, Chinese Herbal; Fatty Alcohols; Plants, Medicinal; Primulaceae; Sitosterols; Succinic Acid

To study the chemical constituents in the air-dried part of Conyza blinii.. The constituent isolation was done by solvent-extraction together with column chromatography. Several methods, such as IR, 1HNMR, 13CNMR and MS, were used to determine the structures of the isolated constituents.. Three compounds were isolated from the air-dried part of Conyza blinii and identified as friedelinol, n-triacontanol and daucosterol on the basis of physical and chemical properties and spectroscopic analysis.. These compounds have not been discovered previously in this plant.

Topics: Asteraceae; Drugs, Chinese Herbal; Fatty Alcohols; Molecular Structure; Oleanolic Acid; Plant Shoots; Plants, Medicinal; Sitosterols

Four chemical constituents were isolated from the stems and leaves of Illicium dunnianum: beta-sitosterol (I), 1-triacontanal (II), quercitrin (III) and shikimic acid (IV), and identified on the basis of spectral analysis. Pharmacological experiments have shown that shikimic acid possesses analgesic activities.

Topics: Analgesics; Drugs, Chinese Herbal; Fatty Alcohols; Quercetin; Shikimic Acid; Sitosterols