cytarabine has been researched along with thiazoles in 47 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 6 (12.77) | 18.2507 |
| 2000's | 21 (44.68) | 29.6817 |
| 2010's | 20 (42.55) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Senderoff, RI; Smith, DR; Sokoloski, TD; Weber, PA | 1 |
| Broekema, GJ; Dirven, MW; Hählen, K; Heyenbrok, MW; Huismans, DR; Loonen, AH; Pieters, R; Veerman, AJ | 1 |
| Hefti, F; Knüsel, B; Ohsawa, F; Widmer, HR | 1 |
| Chen, LM; Huang, SH; Hwang, WS; Tseng, MT; Wang, CC | 1 |
| Borg, AG; Burgess, R; Fisher, A; Grey, M; Wood, P; Yin, JA | 1 |
| Alton, P; Elgie, AW; Noordhuis, P; Peters, GJ; Sargent, JM; Taylor, CG; Williamson, CJ | 1 |
| Beauséjour, CM; Cournoyer, D; Delisle, JS; Létourneau, S; Momparler, RL; Palerme, JS | 1 |
| Horowitz, D; King, AG | 1 |
| Berridge, MV; Hood, KA; Miller, JH; Northcote, PT; West, LM | 1 |
| Huismans, DR; Imhof, SM; Loonen, AH; Moll, AC; Schouten-van Meeteren, AY; van der Linden, HC; van der Valk, P; Veerman, AJ | 1 |
| Akutsu, M; Furukawa, Y; Izumi, T; Kano, Y; Ohmine, K; Tsunoda, S | 1 |
| Creutzig, U; Hählen, K; Harbott, J; Huismans, DR; Kaspers, GJ; Pieters, R; Slater, RM; Veerman, AJ; Zimmermann, M; Zwaan, CM | 1 |
| Asou, K; Hirata, R; Ishikawa, M; Kanno, S; Shouji, A | 1 |
| Blazek, B; Hajduch, M; Janostakova, A; Kouzmina, G; Mihal, V; Noskova, V; Orel, M; Pospisilova, D; Safarova, M; Stary, J | 1 |
| Broekhuizen, AJ; Creutzig, U; Gibson, B; Hubeek, I; Kaspers, GJ; Peters, GJ; Schouten van Meeteren, AY; Talianidis, I; van Wering, ER | 1 |
| Broekhuizen, AJ; Hubeek, I; Kaspers, GJ; Peters, GJ | 1 |
| Schinköthe, T; Staib, P; Strunk, T; Tiehen, J | 1 |
| Champy, P; Duyckaerts, C; Féger, J; Hirsch, EC; Höglinger, GU; Khondiker, ME; Lannuzel, A; Lombes, A; Medja, F; Michel, PP; Oertel, WH; Prigent, A; Ruberg, M | 1 |
| Czyzewski, K; Styczynski, J; Wysocki, M | 1 |
| Lehtonen, S; Männistö, PT; Puttonen, KA; Raasmaja, A | 1 |
| Ainoon, O; Cheong, SK; Fazlina, N; Hamidah, H; Hamidah, NH; Jamal, R; Maha, A; Zarina, AL; Zulkifli, SZ | 1 |
| Agis, H; Aichberger, KJ; Esterbauer, H; Haas, OA; Herndlhofer, S; Jäger, U; Knöbl, P; Rabitsch, W; Schwarzinger, I; Sillaber, C; Sperr, WR; Thalhammer, R; Valent, P | 1 |
| Chi, HS; Choi, SJ; Im, HJ; Jang, S; Jun, KR; Lee, JH; Lee, KH; Moon, HN; Park, CJ; Seo, JJ | 1 |
| Beverloo, HB; Cornelissen, JJ; Deenik, W; Valk, PJ; van der Poel-van de Luytgaarde, SC; van Esser, JW; Wattel, MM | 1 |
| Tallman, M | 1 |
| Ayuk, F; Bacher, U; Brümmendorf, TH; Fiedler, W; Hochhaus, A; Iwanski, GB; Klyuchnikov, E; Kröger, N; Ocheni, S; Schafhausen, P; Schnittger, S; Zabelina, T; Zander, AR | 1 |
| Borthakur, G; Cortes, J; Jones, D; Kantarjian, HM; Luthra, R; Rios, MB; Verma, D; Verstovsek, S | 1 |
| Arbitrario, JP; Fox, JA; Hawtin, RE; Howlett, AR; Kumer, JL; Scatena, CD; Silverman, JA | 1 |
| Arslan, M; Erkut, M; Erkut, N; Ersoz, S; Sonmez, M | 1 |
| Burnett, AK; Coles, SJ; Knapper, S; Walsby, EJ | 1 |
| Burnett, AK; Lazenby, M; Pepper, C; Walsby, E | 1 |
| Akao, Y; Horiike, S; Kobayashi, S; Kobayashi, T; Kuroda, J; Matsumoto, Y; Nagoshi, H; Nishida, K; Sasaki, N; Shimura, Y; Taki, T; Taniwaki, M; Tsutsumi, Y; Yamamoto, M | 1 |
| Feldman, EJ | 1 |
| Apperley, J; Foroni, L; Ibrahim, A; Marin, D; Milojkovic, D; Reid, A | 1 |
| Negoro, E; Nishi, R; Takemura, H; Ueda, T; Yamauchi, T | 1 |
| Burger, JA; Challagundla, P; Champlin, RE; Cortes, JE; Estrov, Z; Faderl, S; Ferrajoli, A; Garris, R; Huang, X; Jorgensen, JL; Kantarjian, HM; Kebriaei, P; Luthra, R; O'Brien, S; Ravandi, F; Thomas, DA; Wang, SA; Wen, S | 1 |
| Abruzzo, L; Borthakur, G; Cortes, J; Faderl, S; Jabbour, E; Jorgensen, JL; Kantarjian, H; Konoplev, S; Luthra, R; O'Brien, S; Quintas-Cardama, A; Ravandi, F; Strati, P; Thomas, D | 1 |
| Baldus, CD; Bock, J; Hofmann, WK; Kühl, AA; Mochmann, LH; Neumann, M; Nowak, V; Ortiz-Tanchez, J; von der Heide, EK | 1 |
| Chen, T; Craig, AR; Cripe, LD; Fox, JA; Hawtin, R; Karp, JE; Lancet, JE; Leavitt, RD; Maris, MB; Michelson, GC; Ravandi, F; Roboz, GJ; Stuart, RK | 1 |
| Audemard, A; Bergot, E; Chantepie, S; de la Gastine, B; Gac, AC; Reman, O; Verger, H | 1 |
| Burnett, AK; Clark, RE; Dennis, M; Dignum, H; Hemmaway, C; Hills, RK; Kjeldsen, L; McMullin, MF; Milligan, D; Panoskaltsis, N; Russell, N; Thomas, IF | 1 |
| Hotinski, AK; Lewis, ID; Ross, DM | 1 |
| Bornhäuser, M | 1 |
| Acton, G; Carella, AM; Cortes, J; Craig, AR; Craig, MD; Damon, L; Derigs, HG; Erba, HP; Fox, JA; Gaidano, G; Havelange, V; Heuser, M; Hogge, D; Horst, HA; Jabbour, E; Kantarjian, HM; Klimek, VM; Lancet, JE; Maertens, J; Mehta, C; Odenike, O; Pigneux, A; Powell, BL; Ravandi, F; Recher, C; Ritchie, EK; Roboz, GJ; Sayar, H; Schiller, GJ; Smith, JA; Strickland, SA; Stuart, RK; Thomas, X; Vey, N; Ward, R; Wei, A | 1 |
| Fox, JA; Jamieson, GC; Poi, M; Strickland, SA | 1 |
| Acton, G; Carella, AM; Cortes, JE; Craig, AR; Craig, MD; Egyed, M; Fox, JA; Horst, HA; Jabbour, E; Kantarjian, HM; Klimek, VM; Krug, U; Lancet, JE; Pigneux, A; Ravandi, F; Récher, C; Ritchie, EK; Sayar, H; Schiller, GJ; Smith, JA; Strickland, SA; Stuart, RK; Vey, N; Ward, R | 1 |
| Che, F; Gui, C; Huang, J; Wang, C; Zhang, L | 1 |
3 review(s) available for cytarabine and thiazoles
| Article | Year |
|---|---|
Vosaroxin is a novel topoisomerase-II inhibitor with efficacy in relapsed and refractory acute myeloid leukaemia.
Topics: Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Clinical Trials as Topic; Cytarabine; Humans; Leukemia, Myeloid, Acute; Naphthyridines; Recurrence; Thiazoles; Topoisomerase Inhibitors; Treatment Failure | 2015 |
Molecular and Pharmacologic Properties of the Anticancer Quinolone Derivative Vosaroxin: A New Therapeutic Agent for Acute Myeloid Leukemia.
Topics: Aged; Aged, 80 and over; Animals; Antineoplastic Combined Chemotherapy Protocols; Cytarabine; Double-Blind Method; Haplorhini; Humans; Leukemia, Myeloid, Acute; Mice; Middle Aged; Naphthyridines; Quinolones; Rats; Thiazoles | 2016 |
A Bayesian Network Meta-Analysis Comparing the Efficacies of Eleven Novel Therapies with the Common Salvage Regimen for Relapsed or Refractory Acute Myeloid Leukemia.
Topics: Bayes Theorem; Cytarabine; Disease-Free Survival; Histone Deacetylase Inhibitors; Humans; Leukemia, Myeloid, Acute; Naphthyridines; Neoplasm Recurrence, Local; Odds Ratio; Pyrazoles; Pyrimidines; Remission Induction; Salvage Therapy; Survival Rate; Thiazoles | 2018 |
4 trial(s) available for cytarabine and thiazoles
| Article | Year |
|---|---|
A phase 1b/2 study of vosaroxin in combination with cytarabine in patients with relapsed or refractory acute myeloid leukemia.
Topics: Adolescent; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Cohort Studies; Cytarabine; Drug Resistance, Neoplasm; Female; Follow-Up Studies; Humans; Leukemia, Myeloid, Acute; Male; Maximum Tolerated Dose; Middle Aged; Naphthyridines; Neoplasm Recurrence, Local; Neoplasm Staging; Prognosis; Remission Induction; Salvage Therapy; Survival Rate; Thiazoles; Young Adult | 2015 |
Vosaroxin and vosaroxin plus low-dose Ara-C (LDAC) vs low-dose Ara-C alone in older patients with acute myeloid leukemia.
Topics: Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Cytarabine; Dose-Response Relationship, Drug; Female; Follow-Up Studies; Humans; Leukemia, Myeloid, Acute; Male; Middle Aged; Naphthyridines; Neoplasm Recurrence, Local; Neoplasm Staging; Prognosis; Prospective Studies; Remission Induction; Survival Rate; Thiazoles | 2015 |
Vosaroxin plus cytarabine versus placebo plus cytarabine in patients with first relapsed or refractory acute myeloid leukaemia (VALOR): a randomised, controlled, double-blind, multinational, phase 3 study.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Cytarabine; Disease-Free Survival; Double-Blind Method; Female; Humans; Kaplan-Meier Estimate; Leukemia, Myeloid, Acute; Male; Middle Aged; Naphthyridines; Neoplasm Recurrence, Local; Remission Induction; Thiazoles; Treatment Outcome | 2015 |
Phase 3 results for vosaroxin/cytarabine in the subset of patients ≥60 years old with refractory/early relapsed acute myeloid leukemia.
Topics: Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Cytarabine; Female; Humans; Leukemia, Myeloid, Acute; Male; Middle Aged; Naphthyridines; Recurrence; Thiazoles | 2018 |
40 other study(ies) available for cytarabine and thiazoles
| Article | Year |
|---|---|
Evaluation of antiproliferative agents using a cell-culture model.
Topics: Animals; Bleomycin; Cell Count; Cell Division; Cells, Cultured; Colorimetry; Cricetinae; Cytarabine; Drug Evaluation, Preclinical; Floxuridine; Fluorouracil; Tetrazolium Salts; Thiazoles; Time Factors; Uridine | 1990 |
In vitro drug sensitivity of cells from children with leukemia using the MTT assay with improved culture conditions.
Topics: Asparaginase; Cells, Cultured; Child; Coloring Agents; Culture Media; Cyclophosphamide; Cytarabine; Daunorubicin; Dose-Response Relationship, Drug; Drug Resistance; Drug Screening Assays, Antitumor; Humans; Mechlorethamine; Mercaptopurine; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisolone; Tetrazolium Salts; Thiazoles; Thioguanine; Vincristine | 1990 |
Down-regulation of phosphatidylinositol response to BDNF and NT-3 in cultures of cortical neurons.
Topics: Animals; Blotting, Western; Carbazoles; Cell Survival; Cells, Cultured; Cerebral Cortex; Cytarabine; Down-Regulation; Female; Humans; Hydrolysis; Immunohistochemistry; Indole Alkaloids; Nerve Growth Factors; Nerve Tissue Proteins; Neuroglia; Neurons; Neurotrophin 3; Phosphatidylinositols; Pregnancy; Protein Kinase C; Rats; Tetrazolium Salts; Thiazoles | 1993 |
Prediction of chemotherapy response in human leukemia using in vitro chemosensitivity test.
Topics: Adult; Aged; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow; Coloring Agents; Cytarabine; Daunorubicin; Drug Screening Assays, Antitumor; Female; Humans; Leukemia, Myeloid, Acute; Male; Middle Aged; Mitoxantrone; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisolone; Prognosis; Tetrazolium Salts; Thiazoles | 1993 |
Effect on cell kill of addition of multidrug resistance modifiers cyclosporin A and PSC 833 to cytotoxic agents in acute myeloid leukaemia.
Topics: Acute Disease; Adolescent; Adult; Aged; Antibiotics, Antineoplastic; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Cell Survival; Coloring Agents; Cyclosporine; Cyclosporins; Cytarabine; Daunorubicin; Drug Resistance, Neoplasm; Drug Synergism; Etoposide; Female; Humans; Idarubicin; Leukemia, Myeloid; Male; Middle Aged; Mitoxantrone; Tetrazolium Salts; Thiazoles; Tumor Cells, Cultured | 1997 |
Modulation of resistance to ara-C by bryostatin in fresh blast cells from patients with AML.
Topics: Acute Disease; Antineoplastic Agents; Arabinofuranosylcytosine Triphosphate; Bryostatins; Cell Death; Cytarabine; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Humans; Lactones; Leukemia, Myeloid; Leukocytes, Mononuclear; Macrolides; Tetrazolium Salts; Thiazoles | 1998 |
Coexpression of rat glutathione S-transferase A3 and human cytidine deaminase by a bicistronic retroviral vector confers in vitro resistance to nitrogen mustards and cytosine arabinoside in murine fibroblasts.
Topics: 3T3 Cells; Animals; Antimetabolites, Antineoplastic; Antineoplastic Agents, Alkylating; Blotting, Southern; Cell Division; Cytarabine; Cytidine Deaminase; DNA, Complementary; Drug Resistance, Neoplasm; Fibroblasts; Gene Transfer Techniques; Genetic Vectors; Glutathione Transferase; Humans; Mechlorethamine; Melphalan; Mice; Protein Biosynthesis; Rats; Retroviridae; Tetrazolium Salts; Thiazoles; Transduction, Genetic | 2000 |
Colorimetric determination of inhibition of hematopoietic progenitor cells in soft agar.
Topics: Animals; Antimetabolites; Antimetabolites, Antineoplastic; Antiviral Agents; Colony-Forming Units Assay; Colony-Stimulating Factors; Colorimetry; Coloring Agents; Cytarabine; Cytokines; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Female; Fluorouracil; Ganciclovir; Growth Inhibitors; Hematopoietic Stem Cells; Humans; Inhibitory Concentration 50; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Tetrazolium Salts; Thiazoles; Zidovudine | 2000 |
Induction of apoptosis by the marine sponge (Mycale) metabolites, mycalamide A and pateamine.
Topics: Animals; Annexin A5; Apoptosis; Cell Survival; Coloring Agents; Cycloheximide; Cytarabine; DNA; DNA Damage; Electrophoresis, Agar Gel; Enzyme Inhibitors; Epoxy Compounds; Flow Cytometry; Inhibitory Concentration 50; Macrolides; Models, Chemical; Porifera; Protein Synthesis Inhibitors; Puromycin; Pyrans; Tetrazolium Salts; Thiazoles; Trypan Blue | 2001 |
Histopathologic features of retinoblastoma and its relation with in vitro drug resistance measured by means of the MTT assay.
Topics: Antineoplastic Agents; Cell Differentiation; Cell Size; Cytarabine; Drug Resistance; Drug Screening Assays, Antitumor; Humans; Retinoblastoma; Tetrazolium Salts; Thiazoles; Tumor Cells, Cultured | 2001 |
Schedule-dependent synergism and antagonism between methotrexate and cytarabine against human leukemia cell lines in vitro.
Topics: Antineoplastic Combined Chemotherapy Protocols; Cell Cycle; Cytarabine; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Screening Assays, Antitumor; Drug Synergism; Humans; Leukemia; Methotrexate; Tetrazolium Salts; Thiazoles; Tumor Cells, Cultured | 2002 |
Cellular drug resistance in childhood acute myeloid leukemia is related to chromosomal abnormalities.
Topics: Acute Disease; Adolescent; Antibiotics, Antineoplastic; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Child; Child, Preschool; Chromosome Aberrations; Chromosome Inversion; Chromosomes, Human; Cladribine; Cytarabine; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Etoposide; Female; Humans; Infant; Leukemia, Myeloid; Male; Neoplastic Stem Cells; Recurrence; Remission Induction; Tetrazolium Salts; Thiazoles; Translocation, Genetic; Trisomy | 2002 |
Effects of naringin on cytosine arabinoside (Ara-C)-induced cytotoxicity and apoptosis in P388 cells.
Topics: Animals; Antimetabolites, Antineoplastic; Antioxidants; Apoptosis; Catalase; Cell Nucleus; Comet Assay; Cytarabine; DNA Fragmentation; Flavanones; Glutathione Peroxidase; Leukemia P388; Mice; Microscopy, Fluorescence; Reactive Oxygen Species; Superoxide Dismutase; Tetrazolium Salts; Thiazoles | 2004 |
The analysis of correlations between drug resistance and clinical/laboratory measures found in a group of children with all treated by ALL-BFM 90 protocol.
Topics: Adolescent; Age Factors; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Child; Child, Preschool; Coloring Agents; Cyclophosphamide; Cytarabine; Daunorubicin; Drug Resistance, Neoplasm; Female; Humans; In Vitro Techniques; Male; Mercaptopurine; Methotrexate; Multivariate Analysis; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Predictive Value of Tests; Prednisone; Remission Induction; Sex Factors; Tetrazolium Salts; Thiazoles; Vincristine | 2004 |
Immunocytochemical detection of deoxycytidine kinase in pediatric malignancies in relation to in vitro cytarabine sensitivity.
Topics: Antimetabolites, Antineoplastic; Brain; Brain Neoplasms; Cell Line, Tumor; Coloring Agents; Cytarabine; Deoxycytidine Kinase; Drug Resistance, Neoplasm; Humans; Immunohistochemistry; Leukemia; Neoplasms; Retinoblastoma; Tetrazolium Salts; Thiazoles | 2004 |
Modulation of cytarabine induced cytotoxicity using novel deoxynucleoside analogs in the HL60 cell line.
Topics: Antimetabolites, Antineoplastic; Antineoplastic Agents; Cell Line, Tumor; Cladribine; Coloring Agents; Cytarabine; Deoxycytidine; DNA; Gemcitabine; HL-60 Cells; Humans; Inhibitory Concentration 50; Nucleosides; Tetrazolium Salts; Thiazoles; Vidarabine | 2004 |
Determination of caspase-3 activation fails to predict chemosensitivity in primary acute myeloid leukemia blasts.
Topics: Adult; Aged; Antineoplastic Agents; Apoptosis; Bone Marrow Cells; Caspase 3; Caspases; Cell Death; Cell Line, Tumor; Cytarabine; Daunorubicin; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Enzyme Activation; Female; Humans; Kinetics; Leukemia, Myeloid, Acute; Male; Middle Aged; Spectrometry, Fluorescence; Tetrazolium Salts; Thiazoles | 2005 |
The mitochondrial complex I inhibitor rotenone triggers a cerebral tauopathy.
Topics: alpha-Synuclein; Amyloid beta-Peptides; Analysis of Variance; Animals; Antineoplastic Combined Chemotherapy Protocols; Behavior, Animal; Benzothiazoles; Body Weight; Caspase 3; Caspases; Cell Death; Cerebral Cortex; Cytarabine; Diagnostic Imaging; Dopamine and cAMP-Regulated Phosphoprotein 32; Doxorubicin; Dystonia; Electron Transport Complex III; Enzyme Activation; Glial Fibrillary Acidic Protein; Immunohistochemistry; Locomotion; Male; Microscopy, Electron, Transmission; Mitochondria; Neurons; Phosphopyruvate Hydratase; Phosphorylation; Posture; Psychomotor Performance; Rats; Rats, Inbred Lew; Rotenone; tau Proteins; Tauopathies; Thiazoles; Time Factors; Tyrosine; Tyrosine 3-Monooxygenase; Ubiquitin; Uncoupling Agents | 2005 |
Ex vivo activity of thalidomide in childhood acute leukemia.
Topics: Angiogenesis Inhibitors; Cell Cycle; Child; Child, Preschool; Cytarabine; Female; Humans; Immunophenotyping; Infant; Leukemia, Myeloid, Acute; Male; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisolone; Tetrazolium Salts; Thalidomide; Thiazoles | 2006 |
A prolyl oligopeptidase inhibitor, Z-Pro-Prolinal, inhibits glyceraldehyde-3-phosphate dehydrogenase translocation and production of reactive oxygen species in CV1-P cells exposed to 6-hydroxydopamine.
Topics: Actins; Blotting, Western; Cell Line; Cell Survival; Cytarabine; Dipeptides; Glyceraldehyde-3-Phosphate Dehydrogenases; Humans; Oxidopamine; Prolyl Oligopeptidases; Protease Inhibitors; Protein Transport; Proto-Oncogene Proteins c-bcl-2; Pyrrolidines; Reactive Oxygen Species; Serine Endopeptidases; Tetrazolium Salts; Thiazoles; Tumor Suppressor Protein p53 | 2006 |
Expression of multidrug resistance (MDR) proteins and in vitro drug resistance in acute leukemias.
Topics: Acute Disease; Adolescent; Adult; Age Factors; Aged; Aged, 80 and over; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B; Cell Survival; Child; Child, Preschool; Coloring Agents; Cytarabine; Daunorubicin; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Female; Humans; Infant; Inhibitory Concentration 50; Leukemia; Leukemia, Myeloid; Male; Methylphenazonium Methosulfate; Middle Aged; Neoplasm Proteins; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Recurrence; Staining and Labeling; Tetrazolium Salts; Thiazoles; Treatment Outcome; Tumor Cells, Cultured | 2007 |
Liposomal cytarabine for treatment of myeloid central nervous system relapse in chronic myeloid leukaemia occurring during imatinib therapy.
Topics: Aged; Antimetabolites, Antineoplastic; Benzamides; Central Nervous System Neoplasms; Cytarabine; Dasatinib; Drug Therapy, Combination; Female; Humans; Imatinib Mesylate; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Liposomes; Male; Middle Aged; Piperazines; Protein Kinase Inhibitors; Pyrimidines; Thiazoles; Treatment Outcome | 2007 |
Relationship between in vitro chemosensitivity assessed with MTT assay and clinical outcomes in 103 patients with acute leukemia.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antibiotics, Antineoplastic; Child; Child, Preschool; Coloring Agents; Cytarabine; Daunorubicin; Drug Evaluation, Preclinical; Drug Resistance, Neoplasm; Female; Humans; Infant; Leukemia, Biphenotypic, Acute; Leukemia, Myeloid, Acute; Male; Middle Aged; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Tetrazolium Salts; Thiazoles; Treatment Outcome | 2007 |
Rapid complete cytogenetic remission after upfront dasatinib monotherapy in a patient with a NUP214-ABL1-positive T-cell acute lymphoblastic leukemia.
Topics: Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Combined Modality Therapy; Cytarabine; Dasatinib; Daunorubicin; Granulocyte Colony-Stimulating Factor; Humans; In Situ Hybridization, Fluorescence; Male; Methotrexate; Mitoxantrone; Neoplasm Proteins; Neutropenia; Oncogene Proteins, Fusion; Peripheral Blood Stem Cell Transplantation; Precursor T-Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Pyrimidines; Remission Induction; Splenic Rupture; Thiazoles; Vincristine; Young Adult | 2009 |
Existing and emerging therapeutic options for the treatment of acute myeloid leukemia.
Topics: Adenine; Adenine Nucleotides; Aminoglycosides; Anti-Inflammatory Agents, Non-Steroidal; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Arabinonucleosides; Carbazoles; Clofarabine; Cytarabine; Dasatinib; Daunorubicin; fms-Like Tyrosine Kinase 3; Furans; Gemtuzumab; Humans; Leukemia, Myeloid, Acute; Naphthalimides; Organophosphonates; Prognosis; Protein Kinase Inhibitors; Pyrimidines; Sesquiterpenes; Staurosporine; Stem Cell Transplantation; Thiazoles; Tretinoin | 2008 |
Characterisation of extramedullary relapse in patients with chronic myeloid leukemia in advanced disease after allogeneic stem cell transplantation.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Benzamides; Cytarabine; Dasatinib; Dexamethasone; Female; Humans; Imatinib Mesylate; Immunotherapy, Adoptive; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Male; Middle Aged; Piperazines; Pyrimidines; Radiotherapy; Recurrence; Stem Cell Transplantation; Thiazoles; Transplantation, Homologous; Treatment Outcome | 2009 |
Chronic myeloid leukemia (CML) with P190 BCR-ABL: analysis of characteristics, outcomes, and prognostic significance.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Benzamides; Blast Crisis; Cyclophosphamide; Cytarabine; Dasatinib; Dexamethasone; Disease-Free Survival; Doxorubicin; Female; Fusion Proteins, bcr-abl; Humans; Idarubicin; Imatinib Mesylate; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Male; Middle Aged; Piperazines; Protein Kinase Inhibitors; Pyrimidines; Retrospective Studies; Survival Rate; Thiazoles; Vincristine | 2009 |
Voreloxin, a first-in-class anticancer quinolone derivative, acts synergistically with cytarabine in vitro and induces bone marrow aplasia in vivo.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Blood Platelets; Bone Marrow Cells; Cell Proliferation; Cytarabine; Disease Models, Animal; Drug Synergism; Female; HL-60 Cells; Humans; Leukemia, Promyelocytic, Acute; Leukocytes; Mice; Naphthyridines; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Thiazoles | 2010 |
A case of acute colitis with severe rectal bleeding in a patient with chronic myeloid leukemia after dasatinib use.
Topics: Acute Disease; Antineoplastic Combined Chemotherapy Protocols; Benzamides; Colitis; Cytarabine; Dasatinib; Female; Gastrointestinal Hemorrhage; Humans; Idarubicin; Imatinib Mesylate; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Male; Middle Aged; Piperazines; Pyrimidines; Rectal Diseases; Thiazoles | 2010 |
The topoisomerase II inhibitor voreloxin causes cell cycle arrest and apoptosis in myeloid leukemia cells and acts in synergy with cytarabine.
Topics: Apoptosis; Cell Culture Techniques; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Cytarabine; DNA Topoisomerases, Type II; Dose-Response Relationship, Drug; Drug Synergism; Female; Gene Deletion; Genes, p53; Humans; Lethal Dose 50; Leukemia, Myeloid, Acute; Male; Middle Aged; Myeloid Cells; Naphthyridines; Thiazoles; Topoisomerase II Inhibitors | 2011 |
The cyclin-dependent kinase inhibitor SNS-032 has single agent activity in AML cells and is highly synergistic with cytarabine.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Apoptosis; Cell Cycle; Cells, Cultured; Cyclin-Dependent Kinases; Cytarabine; Drug Synergism; Female; Humans; Leukemia, Myeloid, Acute; Male; Middle Aged; Oxazoles; Phosphorylation; Thiazoles | 2011 |
Bcl-2 is a better therapeutic target than c-Myc, but attacking both could be a more effective treatment strategy for B-cell lymphoma with concurrent Bcl-2 and c-Myc overexpression.
Topics: Aniline Compounds; Antineoplastic Agents; Blotting, Western; Cell Line, Tumor; Cell Survival; Chromosomes, Human, Pair 14; Chromosomes, Human, Pair 18; Cytarabine; Dose-Response Relationship, Drug; Doxorubicin; Drug Synergism; Etoposide; Gene Expression Regulation, Neoplastic; Humans; Lymphoma, Large B-Cell, Diffuse; MicroRNAs; Proto-Oncogene Proteins c-bcl-2; Proto-Oncogene Proteins c-myc; Reverse Transcriptase Polymerase Chain Reaction; Spectral Karyotyping; Sulfonamides; Thiazoles; Translocation, Genetic | 2011 |
Does therapy-related AML have a poor prognosis, independent of the cytogenetic/molecular determinants?
Topics: Adenine; Anthracyclines; Antineoplastic Agents; Biomarkers, Tumor; Cytarabine; Cytogenetics; Female; Germany; Humans; Leukemia, Myeloid, Acute; Middle Aged; Myelodysplastic Syndromes; Naphthalimides; Naphthyridines; Organophosphonates; Prognosis; Remission Induction; Retrospective Studies; Survival Rate; Thiazoles | 2011 |
Efficacy of combining dasatinib and FLAG-IDA for patients with chronic myeloid leukemia in blastic transformation.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Blast Crisis; Cytarabine; Dasatinib; Female; Granulocyte Colony-Stimulating Factor; Humans; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Male; Middle Aged; Pyrimidines; Thiazoles; Treatment Outcome; Vidarabine | 2012 |
Combination of guanine arabinoside and Bcl-2 inhibitor YC137 overcomes the cytarabine resistance in HL-60 leukemia cell line.
Topics: Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Arabinonucleosides; Cytarabine; Drug Resistance, Neoplasm; HL-60 Cells; Humans; Leukemia, Myeloid, Acute; Proto-Oncogene Proteins c-bcl-2; Thiazoles | 2013 |
Detection of MRD may predict the outcome of patients with Philadelphia chromosome-positive ALL treated with tyrosine kinase inhibitors plus chemotherapy.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Benzamides; Cyclophosphamide; Cytarabine; Dasatinib; Dexamethasone; Doxorubicin; Female; Flow Cytometry; Follow-Up Studies; Fusion Proteins, bcr-abl; Humans; Imatinib Mesylate; Immunoglobulin Heavy Chains; Male; Methotrexate; Middle Aged; Neoplasm Recurrence, Local; Neoplasm Staging; Neoplasm, Residual; Philadelphia Chromosome; Piperazines; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Prognosis; Pyrimidines; Real-Time Polymerase Chain Reaction; Remission Induction; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Survival Rate; Thiazoles; Vincristine; Young Adult | 2013 |
HCVAD plus imatinib or dasatinib in lymphoid blastic phase chronic myeloid leukemia.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Benzamides; Blast Crisis; Cyclophosphamide; Cytarabine; Dasatinib; Dexamethasone; Doxorubicin; Female; Hematopoietic Stem Cell Transplantation; Humans; Imatinib Mesylate; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Male; Methotrexate; Middle Aged; Piperazines; Pyrimidines; Thiazoles; Vincristine | 2014 |
ERG induces a mesenchymal-like state associated with chemoresistance in leukemia cells.
Topics: Antimetabolites, Antineoplastic; Apoptosis; Cytarabine; Dasatinib; DNA Repair; Drug Resistance, Neoplasm; Gene Expression Profiling; Humans; K562 Cells; Mesoderm; Precursor T-Cell Lymphoblastic Leukemia-Lymphoma; Prognosis; Protein-Tyrosine Kinases; Pyrimidines; Signal Transduction; Thiazoles; Trans-Activators; Transcriptional Regulator ERG | 2014 |
[Dasatinib-related pneumonia? An example of pharmacovigilance survey].
Topics: Antineoplastic Combined Chemotherapy Protocols; Blast Crisis; Cyclophosphamide; Cytarabine; Dasatinib; Dexamethasone; Doxorubicin; Filgrastim; Granulocyte Colony-Stimulating Factor; Humans; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Male; Methotrexate; Middle Aged; Pharmacovigilance; Pneumonia; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Protein Kinase Inhibitors; Pyrimidines; Recombinant Proteins; Thiazoles; Tomography, X-Ray Computed; Vincristine | 2015 |
Vosaroxin in acute myeloid leukaemia.
Topics: Cytarabine; Female; Humans; Leukemia, Myeloid, Acute; Male; Naphthyridines; Neoplasm Recurrence, Local; Thiazoles | 2015 |