cytarabine and tetrahydrouridine

cytarabine has been researched along with tetrahydrouridine in 35 studies

Research

Studies (35)

Timeframe	Studies, this research(%)	All Research%
pre-1990	26 (74.29)	18.7374
1990's	9 (25.71)	18.2507
2000's	0 (0.00)	29.6817
2010's	0 (0.00)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Wentworth, DF; Wolfenden, R	1
Furner, RL; Mellett, LB	1
Chabner, BA; Coleman, CN; Johns, DG	1
Ho, DH	1
Cohen, SS	1
Arlin, Z; Chou, TC; Clarkson, BD; Phillips, FS	1
Burchenal, JH; Currie, VE; Krakoff, IH; Mackey, RW; Tan, CT; Wong, PP; Young, CW	1
Chabner, BA; Drake, JC; Hande, KR	1
Mak, TW; Wan, CW	1
Gordon, CS; Krakoff, IH; Kreis, W; Woodcock, TM	1
Hession, C; Kreis, W; Scully, K; Soricelli, A	1
Furner, RL; Herren, TC; Mellett, LB	1
Barra, Y; Cano, JP; Carcassonne, Y; Riva, C; Rustum, Y	1
Laliberté, J; Marquez, VE; Momparler, RL	1
Oh-hara, T; Tsukahara, S; Tsuruo, T; Yusa, K	1
Mejer, J	1
Akerman, S; Allen, SL; Budman, DR; Chan, K; Freeman, J; Kreis, W; Lichtman, S; Schulman, P; Schuster, M; Weiselberg, L	1
Bhalla, K; Grant, S; McCrady, C	1
Mejer, J; Mortensen, BT	1
Heinemann, V; Plunkett, W	1
Engle, KK; Higuchi, T; Liversidge, GG; Nishihata, T	1
Allen, S; Budman, DR; Chan, K; Deere, M; Freeman, J; Henderson, V; Kreis, W; Lichtman, S; Schulman, P; Weiselberg, L	1
Avramis, VI; Powell, W	1
Driscoll, JS; Kelley, JA; Marquez, VE; McCormack, JJ; Roth, JS	1
Benhura, MA	1
Benjamin, RS; Bodey, GP; Brown, NS; Carter, CJ; Freireich, EJ; Hester, J; Ho, DH; McCredie, K	1
Mathews, CK; North, TW	1
Cysyk, RL; Hoerauf, RM; Karle, JM	1
Chabner, B; Glaubiger, DL; Poplack, DG; Riccardi, R; Wood, J	1
Bunch, C; Grahame-Smith, DG; Harris, AL; Potter, CG	1
Harris, AL	1
Chou, TC; Feinberg, A; Fox, JJ; Grant, AJ; Philips, FS; Reichman, U; Vidal, P; Watanabe, KA	1
Oh-hara, T; Tsuruo, T; Yusa, K	1
Akerman, S; Allen, SL; Barile, B; Budman, DR; DeMarco, LC; Kreis, W; Marsh, JH; Schulman, P; Schuster, MW	1
Cournoyer, D; Eliopoulos, N; Momparler, RL	1

Reviews

2 review(s) available for cytarabine and tetrahydrouridine

Article	Year
The mechanisms of lethal action of arabinosyl cytosine (araC) and arabinosyl adenine (araA). Cancer, 1977, Volume: 40, Issue:1 Suppl Topics: Adenine; Adenosine Deaminase Inhibitors; Adenosine Monophosphate; Adenosine Triphosphate; Animals; Azepines; Cell Division; Cell Survival; Cells, Cultured; Cytarabine; Cytidine Deaminase; Cytosine Nucleotides; Deoxyribonucleosides; DNA; Humans; Inosine Nucleotides; Leukemia; Tetrahydrouridine; Vidarabine; Virus Diseases	1977
Metabolism of 1-beta-D-arabinofuranosylcytosine in human leukemic cells. Cancer research, 1977, Volume: 37, Issue:10 Topics: Bone Marrow; Cytarabine; DNA, Neoplasm; Drug Therapy, Combination; Female; Humans; In Vitro Techniques; Leukemia; Leukemia, Lymphoid; Leukemia, Myeloid; Male; RNA, Neoplasm; Tetrahydrouridine; Thymidine	1977

Article

Year

The mechanisms of lethal action of arabinosyl cytosine (araC) and arabinosyl adenine (araA).

Cancer, 1977, Volume: 40, Issue:1 Suppl

Topics: Adenine; Adenosine Deaminase Inhibitors; Adenosine Monophosphate; Adenosine Triphosphate; Animals; Azepines; Cell Division; Cell Survival; Cells, Cultured; Cytarabine; Cytidine Deaminase; Cytosine Nucleotides; Deoxyribonucleosides; DNA; Humans; Inosine Nucleotides; Leukemia; Tetrahydrouridine; Vidarabine; Virus Diseases

1977

Metabolism of 1-beta-D-arabinofuranosylcytosine in human leukemic cells.

Cancer research, 1977, Volume: 37, Issue:10

Topics: Bone Marrow; Cytarabine; DNA, Neoplasm; Drug Therapy, Combination; Female; Humans; In Vitro Techniques; Leukemia; Leukemia, Lymphoid; Leukemia, Myeloid; Male; RNA, Neoplasm; Tetrahydrouridine; Thymidine

1977

Trials

2 trial(s) available for cytarabine and tetrahydrouridine

Article	Year
Phase I evaluation of tetrahydrouridine combined with cytosine arabinoside. Cancer treatment reports, 1979, Volume: 63, Issue:8 Topics: Bone Marrow; Clinical Trials as Topic; Cytarabine; Drug Evaluation; Drug Synergism; Drug Therapy, Combination; Humans; Leukemia; Lymphoma; Middle Aged; Neoplasms; Nucleoside Deaminases; Pyrimidine Nucleosides; Tetrahydrouridine; Uridine	1979
Therapy of refractory/relapsed acute leukemia with cytosine arabinoside plus tetrahydrouridine (an inhibitor of cytidine deaminase)--a pilot study. Leukemia, 1991, Volume: 5, Issue:11 Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Cytarabine; Drug Administration Schedule; Drug Evaluation; Female; Humans; Leukemia; Male; Metabolic Clearance Rate; Middle Aged; Tetrahydrouridine	1991

Article

Year

Phase I evaluation of tetrahydrouridine combined with cytosine arabinoside.

Cancer treatment reports, 1979, Volume: 63, Issue:8

Topics: Bone Marrow; Clinical Trials as Topic; Cytarabine; Drug Evaluation; Drug Synergism; Drug Therapy, Combination; Humans; Leukemia; Lymphoma; Middle Aged; Neoplasms; Nucleoside Deaminases; Pyrimidine Nucleosides; Tetrahydrouridine; Uridine

1979

Therapy of refractory/relapsed acute leukemia with cytosine arabinoside plus tetrahydrouridine (an inhibitor of cytidine deaminase)--a pilot study.

Leukemia, 1991, Volume: 5, Issue:11

Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Cytarabine; Drug Administration Schedule; Drug Evaluation; Female; Humans; Leukemia; Male; Metabolic Clearance Rate; Middle Aged; Tetrahydrouridine

1991

Other Studies

31 other study(ies) available for cytarabine and tetrahydrouridine

Article	Year
On the interaction of 3,4,5,6-tetrahydrouridine with human liver cytidine deaminase. Biochemistry, 1975, Nov-18, Volume: 14, Issue:23 Topics: Azacitidine; Binding Sites; Cytarabine; Cytidine Deaminase; Humans; Kinetics; Liver; Nucleoside Deaminases; Protein Binding; Tetrahydrouridine; Uridine	1975
Kinase and deaminase activity in a variety of subcutaneous mouse tumors. Cancer research, 1975, Volume: 35, Issue:7 Topics: Adenocarcinoma; Aminohydrolases; Animals; Cell Line; Chick Embryo; Cytarabine; Freezing; Glioma; Lung Neoplasms; Mammary Neoplasms, Experimental; Melanoma; Mice; Mice, Inbred AKR; Mice, Inbred C3H; Mice, Inbred C57BL; Mice, Inbred DBA; Neoplasms, Experimental; Osteosarcoma; Phosphotransferases; Pyrimidine Nucleotides; Sarcoma 180; Tetrahydrouridine; Uridine	1975
Studies on mechanisms of resistance to cytosine arabinoside: problems in the determination of related enzyme activities in leukemic cells. Annals of the New York Academy of Sciences, 1975, Aug-08, Volume: 255 Topics: Bone Marrow; Bone Marrow Cells; Cytarabine; Cytidine Deaminase; Deoxycytidine; Drug Resistance; Erythrocytes; Granulocytes; Humans; Kinetics; Leukemia, Myeloid; Leukemia, Myeloid, Acute; Nucleoside Deaminases; Phosphotransferases; Tetrahydrouridine	1975
Potential advances in the clinical use of arabinosyl cytosine. Cancer treatment reports, 1977, Volume: 61, Issue:4 Topics: Adult; Cytarabine; Delayed-Action Preparations; Drug Resistance; Humans; In Vitro Techniques; Infusions, Parenteral; Leukemia, Myeloid, Acute; Tetrahydrouridine	1977
Ara-C metabolism: implications for drug resistance and drug interactions. Bulletin du cancer, 1979, Volume: 66, Issue:1 Topics: 3-Deazauridine; Animals; Cytarabine; Cytidine Deaminase; Drug Interactions; Drug Resistance; Humans; Mice; Neoplasms; Tetrahydrouridine	1979
Effect of tetrahydrouridine on the action of 1-beta-D-arabinofuranosylcytosine in synchronized cultures of normal rat kidney cells. Cancer research, 1979, Volume: 39, Issue:10 Topics: Animals; Cell Cycle; Cell Survival; Cells, Cultured; Cytarabine; Cytidine Deaminase; DNA; Drug Synergism; Interphase; Kidney; Rats; Tetrahydrouridine; Time Factors; Uridine	1979
Tetrahydrouridine: Physiologic disposition and effect upon deamination of cytosine arabinoside in man. Cancer treatment reports, 1977, Volume: 61, Issue:7 Topics: Administration, Oral; Biological Availability; Cytarabine; Cytidine Deaminase; Deamination; Dose-Response Relationship, Drug; Drug Therapy, Combination; Half-Life; Humans; Injections, Intravenous; Neoplasms; Tetrahydrouridine; Uridine	1977
Combinations of tetrahydrouridine and cytosine arabinoside in mouse tumors. Cancer treatment reports, 1977, Volume: 61, Issue:7 Topics: Adenocarcinoma; Animals; Cytarabine; Cytidine Deaminase; Deamination; Drug Evaluation; Drug Therapy, Combination; Female; Lung Neoplasms; Mice; Neoplasms, Experimental; Phosphotransferases; Sarcoma, Experimental; Tetrahydrouridine; Tritium; Uridine	1977
Influence of tetrahydrouridine on the phosphorylation of 1-beta-D-arabinofuranosyl-cytosine (ara-C) by enzymes from solid tumors in vitro. The Journal of pharmacology and experimental therapeutics, 1975, Volume: 194, Issue:1 Topics: Adenocarcinoma; Animals; Bone Neoplasms; Cytarabine; Cytidine Deaminase; Deoxycytidine; Female; In Vitro Techniques; Kinetics; L Cells; Liver; Lung Neoplasms; Male; Mice; Neoplasm Transplantation; Neoplasms, Experimental; Osteosarcoma; Phosphorus; Phosphotransferases; Sarcoma 180; Spleen; Tetrahydrouridine; Uridine	1975
Effect of tetrahydrouridine on metabolism and transport of 1-beta-D-arabinofuranosylcytosine in human cells. Chemotherapy, 1992, Volume: 38, Issue:5 Topics: Cells, Cultured; Cytarabine; Humans; Leukemia, Experimental; Liver; Nucleoside Deaminases; Tetrahydrouridine; Tumor Cells, Cultured	1992
Potent inhibitors for the deamination of cytosine arabinoside and 5-aza-2'-deoxycytidine by human cytidine deaminase. Cancer chemotherapy and pharmacology, 1992, Volume: 30, Issue:1 Topics: Antineoplastic Agents; Azacitidine; Azepines; Cytarabine; Cytidine; Cytidine Deaminase; Deamination; Decitabine; Humans; Kinetics; Pyrimidine Nucleosides; Tetrahydrouridine	1992
Human immunodeficiency virus type 1 induces 1-beta-D-arabinofuranosylcytosine resistance in human H9 cell line. The Journal of biological chemistry, 1992, Aug-25, Volume: 267, Issue:24 Topics: Arabinofuranosylcytosine Triphosphate; Cell Division; Cell Line; Cell Survival; Cytarabine; Cytidine Deaminase; Deoxycytidine Kinase; Deoxyribonucleotides; Drug Resistance; HIV-1; Humans; Kinetics; Tetrahydrouridine	1992
The impact of selected nucleosides on the cytotoxicity of Ara-C in HL60 cells. Advances in experimental medicine and biology, 1991, Volume: 309A Topics: Cell Line; Cell Survival; Cytarabine; Cytidine; Deoxyadenosines; Deoxycytidine; Deoxyguanosine; Drug Interactions; Humans; Kinetics; Leukemia, Promyelocytic, Acute; Nucleosides; Tetrahydrouridine; Uridine	1991
Effect of tetrahydrouridine and deoxytetrahydrouridine on the interaction between 2'-deoxycytidine and 1-beta-D-arabinofuranosylcytosine in human leukemia cells. Leukemia research, 1991, Volume: 15, Issue:4 Topics: Arabinofuranosylcytosine Triphosphate; Cell Division; Cytarabine; Cytidine Deaminase; DCMP Deaminase; Deamination; Deoxycytidine; Deoxycytosine Nucleotides; DNA, Neoplasm; Humans; Leukemia; Tetrahydrouridine; Tumor Cells, Cultured	1991
Reduction of ara-C cytotoxicity in HL 60 cells by addition of deoxycytidine, cytidine or increased level of cytidine deaminase. Advances in experimental medicine and biology, 1989, Volume: 253B Topics: Bone Marrow; Bone Marrow Cells; Cell Division; Cytarabine; Cytidine; Cytidine Deaminase; Deoxycytidine; Deoxycytidine Kinase; Humans; Leukemia, Promyelocytic, Acute; Nucleoside Deaminases; Phosphotransferases; Tetrahydrouridine; Tretinoin; Tumor Cells, Cultured	1989
Modulation of deoxynucleotide metabolism by the deoxycytidylate deaminase inhibitor 3,4,5,6-tetrahydrodeoxyuridine. Biochemical pharmacology, 1989, Nov-15, Volume: 38, Issue:22 Topics: Cell Line; Cytarabine; Cytidine Diphosphate; DCMP Deaminase; Deoxycytidine; Deoxycytidine Kinase; Deoxycytosine Nucleotides; Deoxyuridine; Hydroxyurea; Kinetics; Nucleotide Deaminases; Ribonucleotide Reductases; T-Lymphocytes; Tetrahydrouridine; Thymine Nucleotides	1989
Enhanced serum concentrations of Ara-C using suppositories containing tetrahydrouridine as a deamination inhibitor of Ara-C. The Journal of pharmacy and pharmacology, 1986, Volume: 38, Issue:3 Topics: Animals; Arabinofuranosyluracil; Biological Availability; Cytarabine; Deamination; Dogs; Kinetics; Salicylates; Salicylic Acid; Suppositories; Tetrahydrouridine; Uridine	1986
Effect of tetrahydrouridine on the clinical pharmacology of 1-beta-D-arabinofuranosylcytosine when both drugs are coinfused over three hours. Cancer research, 1988, Mar-01, Volume: 48, Issue:5 Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow; Cytarabine; Deamination; Female; Half-Life; Humans; Male; Middle Aged; Tetrahydrouridine; Uridine	1988
Pharmacology of combination chemotherapy of cytosine arabinoside (ara-C) and uracil arabinoside (ara-U) or tetrahydrouridine (THU) against murine leukemia L1210/0 in tumor-bearing mice. Cancer investigation, 1987, Volume: 5, Issue:4 Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Arabinofuranosyluracil; Cytarabine; Deamination; Leukemia L1210; Male; Mice; Tetrahydrouridine; Time Factors; Uridine	1987
Furanose-pyranose isomerization of reduced pyrimidine and cyclic urea ribosides. Journal of medicinal chemistry, 1986, Volume: 29, Issue:11 Topics: Cytarabine; Cytidine Deaminase; Gas Chromatography-Mass Spectrometry; Gastric Acidity Determination; Hydrogen-Ion Concentration; Kinetics; Magnetic Resonance Spectroscopy; Nucleoside Deaminases; Nucleosides; Tetrahydrouridine; Uridine	1986
Metabolism of cytosine arabinoside in Tetrahymena pyriformis. Comparative biochemistry and physiology. B, Comparative biochemistry, 1985, Volume: 80, Issue:4 Topics: Animals; Cell Division; Cytarabine; DNA Replication; Kinetics; Nucleoside Deaminases; Tetrahydrouridine; Tetrahymena pyriformis	1985
Effects of tetrahydrouridine on the uptake and metabolism of 1-beta-D-arabinofuranosylcytosine in human normal and leukemic cells. Cancer research, 1980, Volume: 40, Issue:7 Topics: Bone Marrow; Cells, Cultured; Cytarabine; Humans; Leukemia; Leukemia, Lymphoid; Leukemia, Myeloid; Leukemia, Myeloid, Acute; Leukocytes; Phosphotransferases; Tetrahydrouridine; Uridine	1980
Tetrahydrouridine specifically facilitates deoxycytidine incorporation into herpes simplex virus DNA. Journal of virology, 1981, Volume: 37, Issue:3 Topics: Cytarabine; Deoxycytidine; DNA, Viral; HeLa Cells; Simplexvirus; Tetrahydrouridine; Uridine	1981
Labelling of the thymidine and deoxycytidine bases of DNA by [2-14C]deoxycytidine in cultured L1210 cells. Cancer letters, 1983, Volume: 19, Issue:2 Topics: 3-Deazauridine; Animals; Carbon Radioisotopes; Cytarabine; Cytidine; Deoxycytidine; DNA; Leukemia L1210; Mice; Tetrahydrouridine; Thymidine	1983
Influence of tetrahydrouridine on the pharmacokinetics of intrathecally administered 1-beta-D-arabinofuranosylcytosine. Cancer research, 1982, Volume: 42, Issue:5 Topics: Animals; Cytarabine; Cytidine Deaminase; Half-Life; Injections, Intravenous; Injections, Spinal; Macaca mulatta; Male; Tetrahydrouridine; Uridine	1982
Cytosine arabinoside deamination in human leukaemic myeloblasts and resistance to cytosine arabinoside therapy. Clinical science (London, England : 1979), 1981, Volume: 60, Issue:2 Topics: Adult; Arabinofuranosylcytosine Triphosphate; Arabinofuranosyluracil; Bone Marrow; Cells, Cultured; Cytarabine; Deamination; DNA, Neoplasm; Dose-Response Relationship, Drug; Drug Resistance; Humans; Leukemia, Myeloid, Acute; Tetrahydrouridine	1981
1-beta-D-arabinofuranosylcytosine (ara-C) deamination in human leukemic myeloblasts is not a mechanism of resistance to ara-C therapy. Cancer research, 1981, Volume: 41, Issue:7 Topics: Bone Marrow; Cells, Cultured; Cytarabine; Deamination; Humans; Leukemia, Myeloid, Acute; Tetrahydrouridine	1981
Pharmacological disposition and metabolic fate of 2'-fluoro-5-iodo-1-beta-D-arabinofuranosylcytosine in mice and rats. Cancer research, 1981, Volume: 41, Issue:9 Pt 1 Topics: Animals; Chromatography, High Pressure Liquid; Cytarabine; Deamination; Feces; Injections, Intravenous; Mice; Rats; Tetrahydrouridine; Time Factors; Tissue Distribution	1981
Induction of resistance to 1-beta-D-arabinofuranosylcytosine in human H9 cell line by simian immunodeficiency virus. Biochemical and biophysical research communications, 1995, Jan-17, Volume: 206, Issue:2 Topics: Cell Division; Cell Line; Cell Survival; Cytarabine; Cytidine Deaminase; Drug Resistance; Fluorouracil; Humans; Leukemia-Lymphoma, Adult T-Cell; Mercaptopurine; Simian Immunodeficiency Virus; Tetrahydrouridine; Tumor Cells, Cultured; Vidarabine; Zalcitabine; Zidovudine	1995
Therapy of refractory/relapsed acute myeloid leukemia and blast crisis of chronic myeloid leukemia with the combination of cytosine arabinoside, tetrahydrouridine, and carboplatin. Cancer chemotherapy and pharmacology, 1993, Volume: 31, Issue:6 Topics: Acute Disease; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Blast Crisis; Carboplatin; Cytarabine; Drug Resistance; Female; Humans; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Leukemia, Myeloid; Male; Middle Aged; Recurrence; Tetrahydrouridine; Treatment Outcome	1993
Drug resistance to 5-aza-2'-deoxycytidine, 2',2'-difluorodeoxycytidine, and cytosine arabinoside conferred by retroviral-mediated transfer of human cytidine deaminase cDNA into murine cells. Cancer chemotherapy and pharmacology, 1998, Volume: 42, Issue:5 Topics: 3T3 Cells; Animals; Antimetabolites; Antimetabolites, Antineoplastic; Azacitidine; Colony-Forming Units Assay; Cytarabine; Cytidine Deaminase; Decitabine; Deoxycytidine; DNA, Complementary; Drug Resistance; Enzyme Inhibitors; Fibroblasts; Gemcitabine; Gene Transfer Techniques; Genetic Vectors; Humans; Mice; Phenotype; Retroviridae; Tetrahydrouridine	1998