cytarabine has been researched along with deoxycytidine in 297 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 102 (34.34) | 18.7374 |
| 1990's | 64 (21.55) | 18.2507 |
| 2000's | 66 (22.22) | 29.6817 |
| 2010's | 57 (19.19) | 24.3611 |
| 2020's | 8 (2.69) | 2.80 |
| Authors | Studies |
|---|---|
| Chen, MS; Prusoff, WH; Schinazi, RF | 1 |
| Bobek, M; Cheng, YC; Dutschman, G; Grill, S; Kavai, I; Sharma, RA | 1 |
| Cook, PD; McNamara, DJ | 1 |
| Avery, TL; Chwang, TL; Fridland, A | 1 |
| Björck, L; Clausen, AR; Piskur, J; Sandrini, MP; Shannon, O | 1 |
| Kreis, W; Meyers, MB | 2 |
| Boldogh, I; Roubal, J; Vejsada, J; Vonka, V; Závada, V | 1 |
| Karon, M; Lee, T; Monparler, RL | 1 |
| Chabner, BA; Coleman, CN; Drake, JC; Stoller, RG | 1 |
| Buchman, VM; Lichinitser, MR; Mkheidze, DM; Svet-Moldavsky, GJ | 1 |
| Chu, BC; Lawley, PD | 1 |
| Chu, MY; Fischer, GA; Hoovis, ML | 1 |
| Cohen, A; Ho, L | 1 |
| Chabner, BA; Coleman, CN; Johns, DG | 1 |
| Brockman, RW; Nelson, JA; Rose, LM; Schabel, FM; Shaddix, SC; Williams, M | 1 |
| Feltkamp-Vroom, TM; Helder, AW; Lucas, CJ; Splinter, TA | 1 |
| Carlevarini, LA; Krakoff, IH; Kreis, W; Meyers, MB; Woodcock, TM | 1 |
| Marz, R; Plagemann, PG; Wohlhueter, RM | 1 |
| Bukhman, VM; Lichinitser, MR; Mkheidze, DM; Svet-Moldavskiĭ, GIa | 1 |
| Barkhotkina, MF; Basieva, TKh; Bukhman, VM | 1 |
| Dunn, WC; Regan, JD | 1 |
| Barkhotkina, MF; Belyanchikova, NI; Buchman, VM; Lichinitser, MR; Litovchenko, TA; Mkheidze, DM; Svet-Moldavsky, GJ | 1 |
| Mattoccia, LP; Sorrentino, R | 1 |
| Mak, TW; Wan, CW | 1 |
| Belianchikova, NI; Bukhman, VM; Svet-Moldavskiĭ, GIa; Vyshinskaia, GIa | 1 |
| Buchman, VM; Lichinitser, MR; Mkheidze, DM; Svet-Maoldavsky, GJ | 1 |
| Baguley, BC; Falkenhaug, EM | 1 |
| Furner, RL; Herren, TC; Mellett, LB | 1 |
| Chou, TC; Hutchison, DJ; Philips, FS; Schmid, FA | 1 |
| Krajewska, E; Shugar, D | 1 |
| Adamson, DJ; Carpenter, JW; Nelson, JA; Rose, LM | 1 |
| Harrap, KR; Mulder, JH | 1 |
| Glässer, D; Iwig, M | 1 |
| Chan, TS; Green, H; Long, C | 1 |
| Fischer, GA; Theiss, JC | 1 |
| Schrek, R; Stefani, SS | 1 |
| Mancini, WR | 1 |
| Sasvári-Székely, M; Spasokukotskaja, T; Staub, M; Taljanidisz, J | 2 |
| Fujita, H; Okamoto, M | 1 |
| Gococo, KO; Lass, JH; Lazarus, HM | 1 |
| Bhalla, K; Bullock, G; Holladay, C; Ibrado, AM; Jasiok, M; Lutzky, J; Singh, S | 1 |
| Birnbaum, GI; Cheng, YC; Clarke-Katzenburg, RH; Gabe, EJ; Giziewicz, J; Lin, TS; Liu, MC; Luo, MZ; Mancini, WR; Prusoff, WH | 1 |
| Nakamura, T; Ueda, T | 1 |
| Balzarini, J; De Clercq, E; Neyts, J; Snoeck, R | 1 |
| Johnson, EM; Martin, DP; Wallace, TL | 1 |
| Chou, TC; Kong, XB; Tong, WP | 1 |
| De Clercq, E; Marquez, VE; Murase, J | 1 |
| Chubb, S; Grindey, GB; Hertel, LW; Huang, P; Plunkett, W | 1 |
| Cuddy, DP; de Valeriola, DL; Egorin, MJ; Forrest, A; Ross, DD | 1 |
| Mejer, J | 2 |
| Bouffard, DY; Momparler, LF; Momparler, RL | 1 |
| Arita, M; Fujii, A; Matsuda, A; Okumoto, T; Sakata, S; Sasaki, T; Ueda, T; Yamagami, K | 1 |
| Bhalla, K; Grant, S; McCrady, C | 1 |
| Arlin, Z; Bhalla, K; Grant, S; Howe, CW | 1 |
| Grant, S; Howe, C; Kuczynski, T | 1 |
| Gandhi, V; Plunkett, W | 1 |
| Bhalla, K; Gleyzer, M; Grant, S | 1 |
| Akiyama, Y; Kubota, M; Mikawa, H; Takimoto, T; Tanizawa, A | 1 |
| Botti, RE; Imperia, PS; Lass, JH; Lazarus, HM; Mack, RJ | 1 |
| Mejer, J; Mortensen, BT | 1 |
| Akiyama, Y; Kiriyama, Y; Kitoh, T; Kubota, M; Mikawa, H; Takimoto, T; Tanizawa, A | 1 |
| Shirai, T; Umeda, M | 1 |
| Johnson, EM; Wallace, TL | 1 |
| Heinemann, V; Plunkett, W | 1 |
| Kopper, L; Pogany, G; Sasvári-Székely, M; Soóki-Tóth, A; Spasokukotskaja, T; Staub, M | 1 |
| Benczur, M; Spasokukotskaja, T; Staub, M; Taljanidisz, J | 1 |
| Guschlbauer, W; Hay, J; Jamieson, AT; Mengel, R; Wohlrab, F | 1 |
| Arnett, G; Coburn, WC; O'Dell, CA; Riordan, JM; Shannon, WM; Shealy, YF; Thorpe, MC | 1 |
| Downes, CS; Elliott, GC | 1 |
| Deknudt, G; Kalina, I; Léonard, A | 1 |
| Hartnett, ME; Lass, JH; Lazarus, HM; Murphy, BF; Reed, MD | 1 |
| Fujii, A; Matsuda, A; Sasaki, T; Takenuki, K; Ueda, T; Yamagami, K | 1 |
| Grindey, GB; Heinemann, V; Hertel, LW; Plunkett, W | 1 |
| Gauglitz, G; Hommel, U; Schott, H | 1 |
| Jekunen, A | 1 |
| Ariatti, M; Jones, PA | 1 |
| Arlin, Z; Baker, M; Bhalla, K; Cole, J; Graham, G; Grant, S; MacLaughlin, W | 1 |
| Gressel, M; Hajek, AS; Mallick, KS; Parrish, RK | 1 |
| Balzarini, J | 1 |
| Ashman, CR; Davidson, RL; Kaufman, ER | 1 |
| Coquin, Y | 1 |
| Chou, TC; Fanucchi, MP; Fox, JJ; Watanabe, KA | 1 |
| Ayusawa, D; Balzarini, J; De Clercq, E; Seno, T | 1 |
| Malick, NC; Snyder, RD | 1 |
| Cihák, A; Veselỳ, J | 1 |
| Hosono, H; Kuno, S | 1 |
| Yoshirkura, H | 1 |
| Buttin, G; de Saint-Vincent, BR | 1 |
| Karran, P | 1 |
| Ganeshaguru, K; Hoffbrand, AV; Tattersall, MH | 1 |
| Chang, SY; Derge, JG; Hampar, B; Nonoyama, M; Showalter, SD; Tagamets, A | 1 |
| Sato, K; Shiomi, T | 1 |
| Gentry, GA; Jamieson, AT; Subak-Sharpe, JH | 1 |
| Green, H; Meuth, M | 1 |
| Ho, DH | 1 |
| Cunningham, DD; Remo, RA | 1 |
| Bloch, A; Sharma, RA; Wang, MC | 1 |
| Berger, AE; Kuentzel, SL; Neil, GL | 1 |
| Boggs, DR; Boggs, SS; Neil, GL; Sartiano, G | 1 |
| Akao, T; Fujimoto, S; Ito, B; Miyoshi, T; Nomura, Y | 1 |
| Chou, TC; Colacino, JM; Feinberg, A; Fox, JJ; Lopez, C; Philips, FS; Watanabe, KA | 1 |
| Jones, PA; Taylor, SM | 1 |
| Fox, JJ; Lopez, C; Watanabe, KA | 1 |
| Mathews, CK; North, TW | 1 |
| Balzarini, J; De Clercq, E | 1 |
| Downes, CS; Johnson, RT; Yew, FF | 1 |
| Evans, WE; Sinkule, JA | 1 |
| Lin, TS; Mancini, WR | 1 |
| Green, CG; Mettes, HJ; Shearer, WT | 1 |
| Jones, SP; Sawyer, WH; Wiley, JS | 1 |
| Andreeff, M; Blumenreich, MS; Chou, TC; Clarkson, BD; Vale, K; Young, CW | 1 |
| Renis, HE | 1 |
| Cysyk, RL; Hoerauf, RM; Karle, JM | 1 |
| Goz, B; Orr, C; Wharton, W | 1 |
| Chen, TS | 1 |
| Braun, TJ; Burchenal, JH; Chou, TC; Fox, JJ; Philips, FS; Schmid, FA; Su, TL; Watanabe, KA | 1 |
| Barkhotkina, MF; Belianchikova, NI; Bukhman, VM | 1 |
| Danhauser, LL; Rustum, YM | 1 |
| Cadman, E; Grant, S; Lehman, C | 1 |
| Barkhotkina, MF; Bukhman, VM | 1 |
| Cuddy, DP; Ross, DD | 2 |
| Csoka, K; Larsson, R; Liliemark, J; Nygren, P | 1 |
| Bøyum, A; Løvhaug, D; Nordlie, EM; Seeberg, E | 1 |
| Ben-Ari, Y; Charriaut-Marlangue, C; Dessi, F; Moreau, J; Pollard, H | 1 |
| Parson, SH; Price, JF; Ribchester, RR | 1 |
| Honders, MW; Kester, MG; Landegent, JE; Stegmann, AP; Willemze, R | 1 |
| Chu, JL; Netland, PA; Shields, SR | 1 |
| Findenig, G; Fritzer, M; Lhotka, C; Schön, HJ; Szekeres, T | 1 |
| Kalman, TI; Kerr, SG | 1 |
| Plunkett, W; Xu, YZ | 1 |
| Baker, M; Bhalla, K; Grant, S | 1 |
| Dan, A; Matsuda, A; Minakawa, N; Okazaki, S; Sasaki, T; Sugimoto, Y; Tregear, SJ | 1 |
| Chalovich, JM; Cory, AH; Cory, JG; Shibley, IA | 1 |
| Tsukagoshi, S | 3 |
| Bouffard, DY; Momparler, RL | 1 |
| Smith, G | 1 |
| Bernabei, PA; D'Ippolito, G; Ermini, A; Rossi-Ferrini, P; Santini, V; Zoccolante, A | 1 |
| Blau, CA; Neff, T | 1 |
| Alvord, WG; Gazdar, AF; Gray-Goodrich, M; Koo, HM; McWilliams, MJ; Mikheev, A; Monks, A; Oie, HK; Paull, KD; Rubinstein, LV; Vande Woude, GF; Zarbl, H | 1 |
| Fujii, A; Hosoya, M; Matsuda, A; Okumoto, T; Ono, T; Sakata, S; Sasaki, T; Yamagami, K | 1 |
| Boder, GB; Grindey, GB; Hertel, LW; Houghton, JA; Houghton, PJ; Merriman, RL; Rutherford, PG; Schultz, RM; Tanzer, LR | 1 |
| Wiley, JS | 1 |
| Boix, J; Comella, JX; Sanz-Rodriguez, C | 1 |
| Huang, P; Iwasaki, H; Keating, MJ; Plunkett, W | 1 |
| Cohen, JD; Katz, TB; Marcel, PD; Strock, DJ; Teik, JE | 1 |
| Matsuda, A | 1 |
| Cory, AH; Cory, JG; Nelson, TO; Somerville, L | 1 |
| Heinemann, V; Issels, RD; Schulz, L; Wilmanns, W | 1 |
| Cohen, JD; LaGuardia, EA; Mao, Z; Strock, DJ; Teik, JE | 1 |
| Cournoyer, D; Eliopoulos, N; Momparler, RL | 1 |
| Geisen, F; Konwalinka, G; Schirmer, M; Stegmann, AP | 1 |
| Bergman, AM; Brouwer, M; Eriksson, S; Jongsma, AP; Leyva, A; Peters, GJ; Pinedo, HM; Ruiz van Haperen, VW; Veerman, G | 1 |
| Cree, IA; Foss, AJ; Hungerford, JL; Kurbacher, CM; Myatt, N; Neale, MH; Plowman, PN | 1 |
| Beauséjour, C; Eliopoulos, N; Momparler, RL | 1 |
| Hanaoka, K; Hisaoka, M; Ikeda, T; Iwabuchi, H; Kaneko, M; Kobayashi, T; Kurakata, S; Matsuda, A; Mitsuhashi, Y; Miura, S; Nakagawa, A; Nomura, T; Sasaki, T; Shibayama, T; Suzuki, M; Tanaka, K; Tanzawa, F; Tomida, A; Tsuruo, T; Wataya, Y | 1 |
| Dent, P; Grant, S; Kramer, LB; Povirk, LF; Saunders, AM; Vrana, JA; Zhang, XF | 1 |
| Callet Bauchu, E; Dumontet, C; Fabianowska-Majewska, K; Fang, X; Gandhi, V; Gazzo, S; Lepoivre, M; MacKey, J; Mantincic, D; Peters, GJ; Rolland, MO; Tigaud, I; Vanier-Viornery, A; Voorn, DA; Wyczechowska, D | 1 |
| Johansson, M; Karlsson, A; Van Rompay, AR | 1 |
| Endo, M; Machida, H; Miura, S; Sasaki, T; Satoh, H; Yoshimura, Y | 1 |
| Abdel-Aziz, W; Hickey, RJ; Jiang, HY; Malkas, LH | 1 |
| Allegra, CJ; Chabner, BA; Chu, E; Grem, JL; Johnston, PG; Multani, P; Ryan, D; Takimoto, CH | 1 |
| Braess, J; Hiddemann, W; Jahns-Streubel, G; Kern, W; Keye, S; Schleyer, E; Unterhalt, M; Wegendt, C | 1 |
| Korycka, A; Lech-Maranda, E; Robak, T | 1 |
| Cheng, YC; Chou, KM; Kukhanova, M | 1 |
| Johansson, M; Karlsson, A; Zheng, X | 1 |
| Parker, WB; Rose, LM; Secrist, JA; Shaddix, SC; Shewach, DS; Tiwari, KN; Waud, WR | 1 |
| Lee, C; Tannock, IF | 1 |
| Honma, Y; Ishii, Y; Matsuda, A; Niitsu, N | 1 |
| Azuma, A; Huang, P; Matsuda, A; Plunkett, W | 1 |
| Bergman, AM; Jensen, PB; Munch-Petersen, B; Peters, GJ; Pinedo, HM; Sehested, M; Smid, K; Veerman, G; Voorn, DA | 1 |
| Izuta, S; Miura, S; Satoh, H; Yoshimura, Y | 1 |
| Dumontet, C; Galmarini, CM; Mackey, JR | 1 |
| Kodama, T; Matsuda, A; Nomura, M; Shuto, S | 1 |
| Endo, Y; Matsuda, A; Obata, T; Sasaki, T; Tanaka, M; Uchida, H | 1 |
| Johnson, SA | 1 |
| Cass, CE; Clarke, ML; Gourdeau, H; Jolivet, J; Lafrenière, RG; Lee, N; Mackey, JR; Mowles, D; Ouellet, F; Richard, A; Selner, M; Young, JD | 1 |
| Johansson, M; Karlsson, A; Sanda, A; Zhu, C | 1 |
| Beauséjour, CM; Eliopoulos, N; Le, NL; Momparler, L; Momparler, RL | 1 |
| Cinatl, J; Doerr, HW; Gosselin, G; Gröschel, B; Imbach, JL; Périgaud, C | 1 |
| Bethe, U; Cornely, OA; Pels, H; Ritzkowsky, A; Seibold, M; Soehngen, D; Toepelt, K | 1 |
| Kelly, S; Nguyen, M; Sun, D; Urrabaz, R; Weitman, S | 1 |
| Berger, MR; Georgieva, MC; Konstantinov, SM; Topashka-Ancheva, M | 1 |
| Beauséjour, CM; Gagnon, J; Momparler, RL; Primeau, M | 1 |
| Hojo, K; Maekawa, R; Matsumoto, M; Nishitani, Y; Takeda, Y; Wada, T; Yoshioka, T | 1 |
| Higashihara, M; Honma, Y; Niitsu, N | 1 |
| Chamorey, AL; Milano, G; Thyss, A | 1 |
| Baldwin, SA; Cass, CE; Clarke, ML; Mackey, JR; Young, JD | 1 |
| Parker, WB; Secrist, JA; Shaddix, SC; Someya, H; Tiwari, KN | 1 |
| Clarke, ML; Cros, E; Dumontet, C; Galmarini, CM; Gosselin, G; Jordheim, L; Mackey, JR; Perigaud, C; Santos, CL | 1 |
| Alexander, RL; Fleming, RA; Ishaq, KS; Kucera, GL; Morris-Natschke, SL | 1 |
| EVANS, JS; MENGEL, GD | 1 |
| Ge, Y; Jensen, TL; Matherly, LH; Taub, JW | 1 |
| Bajramovic, JJ; Gonzalez-Dunia, D; Pochet, S; Syan, S; Volmer, R | 1 |
| Bendele, RA; Kuchta, RD; Moore, CL; Richardson, FC; Richardson, KA; Rohloff, JC; Tomkinson, B; Vega, TP | 1 |
| Broekhuizen, AJ; Hubeek, I; Kaspers, GJ; Peters, GJ | 1 |
| Bergman, AM; Hendriks, HR; Kuiper, CM; Myhren, F; Peters, GJ; Sandvold, ML | 1 |
| Dumontet, C; Galmarini, CM; Jordheim, LP | 1 |
| Crump, M; Lin, B; Shepherd, L | 1 |
| Arlander, SJ; Baek, YU; Chen, J; Cliby, WA; Flatten, KS; Hackbarth, JS; Hopkins, KM; Karnitz, LM; Kaufmann, SH; Lieberman, HB; Loegering, D; Thomas, MB; Vroman, BT; Wagner, JM | 1 |
| Bardenheuer, W; Brueckner, A; Flasshove, M; Lehmberg, K; Moritz, T; Rattmann, I; Schneider, A; Seeber, S; Sorg, UR | 1 |
| Crump, M; Keating, A; Kuruvilla, J; Nagy, T; Pintilie, M; Tsang, R | 1 |
| Escherich, G; Hassenpflug, WA; Horstmann, MA; Janka, G; Kabisch, H; zur Stadt, U | 1 |
| Funakoshi, A; Sumii, T | 1 |
| Gardner, J; Gonen, M; Heaney, M; O'Connor, OA; Sirotnak, F; Smith, EA; Teruya-Feldstein, J; Toner, LE; Vrhovac, R | 1 |
| Cavallo, D; Colombi, A; Giglio, M; Iavicoli, S; Marinaccio, A; Ursini, CL | 1 |
| Fujimoto, S; Hotta, A; Koma, M; Nagai, K; Nagasawa, K | 1 |
| Bardenheuer, W; Brueckner, A; Flasshove, M; Hilger, RA; Kleff, V; Moritz, T; Opalka, B; Rattmann, I; Seeber, S; Sorg, UR | 1 |
| Fangusaro, J; Finlay, J; Rook, J; Rosser, T | 1 |
| Balzarotti, M; Bramanti, S; Castagna, L; Magagnoli, M; Mazza, R; Nozza, A; Russo, F; Santoro, A; Sarina, B; Siracusano, L; Timofeeva, I; Todisco, E | 1 |
| Nishi, R; Ueda, T; Yamauchi, T | 1 |
| Bergman, AM; Eijk, PP; Peters, GJ; Smid, K; van den Ijssel, P; van Haperen, VW; Veerman, G; Ylstra, B | 1 |
| Bergman, AM; Hoebe, EK; Kamphuis, JA; Laan, AC; Peters, GJ; Sigmond, J | 1 |
| Benhadji, K; Calvo, F; Chiao, J; Cvitkovic, E; Faivre, S; Galmarini, CM; Ghoul, A; Green, SR; Le Tourneau, C; Raymond, E; Serova, M | 1 |
| Lansiaux, A; Lokiec, F | 1 |
| Couvreur, P; Desmaële, D; Dubernet, C; Marque, PE; Mouelhi, SL; Reddy, LH | 1 |
| Adams, DJ; Giles, F; Jacobsen, TF; Myhren, F; Rizzieri, DA; Sandvold, ML | 1 |
| Ames, M; Batzler, A; Fridley, B; Hildebrandt, M; Jenkins, G; Kalari, K; Li, L; Safgren, S; Schaid, D; Wang, L | 1 |
| Galmarini, CM; Kohli, E; Mitin, A; Vinogradov, SV; Warren, G; Zeman, A | 1 |
| Galmarini, CM; Myhren, F; Sandvold, ML | 1 |
| Chen, ZS; Hopper-Borge, E; Kruh, GD; Shen, T; Shi, Z; Xu, X | 1 |
| Hazra, S; Konrad, M; Lavie, A; Ort, S; Sabini, E | 1 |
| Bulusu, R; Camilleri, D; Follows, G; Marcus, R; Raj, S; Stafford, G; Todd, T; Williams, M | 1 |
| Brody, JR; Costantino, CL; Cozzitorto, JA; Dasgupta, A; Gorospe, M; Keen, JC; Kennedy, EP; Kuwano, Y; Witkiewicz, AK; Yeo, CJ | 1 |
| Aksoy, P; Eckloff, BW; Kalari, KR; Moon, I; Pelleymounter, LL; Wang, L; Weinshilboum, RM; Wieben, ED; Yee, VC; Zhu, MJ | 1 |
| Batzler, A; Fridley, BL; Jenkins, G; Kalari, K; Li, L; Wang, L; Weinshilboum, RM | 1 |
| García-Sanz, R; González-López, TJ; Graciani, IF; Hermida, G; San Miguel, JF; Vázquez, L | 1 |
| Adema, AD; Fichtner, I; Laan, AC; Myhren, F; Peters, GJ; Sandvold, ML; Verheul, HM | 1 |
| Hasegawa, R; Kamatani, N; Kaniwa, N; Kawamoto, M; Kim, SR; Kim, WY; Lee, SJ; Lee, SS; Okuda, H; Saito, Y; Sawada, J; Shin, JG; Sugiyama, E; Tohkin, M | 1 |
| Chou, KM; Garcia-Diaz, M; Kunkel, TA; Murray, MS | 1 |
| Adams, J; Blaszkowsky, LS; DeLaney, TF; Fernandez-Del Castillo, C; Hong, TS; Kwak, EL; Mamon, HJ; Mino-Kenudson, M; Ryan, DP; Winrich, B; Yeap, B | 1 |
| Eckert, KA; Polizzi, JM; Prakasha Gowda, AS; Spratt, TE | 1 |
| Chini, EN; Escande, C; Hartman, WR; Kalari, K; Liu, M; Moon, I; Nin, V; Pelleymounter, LL; Weinshilboum, RM; Wu, TY | 1 |
| Chai, HS; Hebbring, SJ; Kalari, KR; Kocher, JP; Li, L; Wang, L; Weinshilboum, RM | 1 |
| Galmarini, C; Myhren, F; Peters, G; Sandvold, ML | 1 |
| Adema, AD; Kathmann, I; Losekoot, N; Myhren, F; Peters, GJ; Sandvold, ML; Smid, K | 1 |
| Galmarini, CM; Senanayake, MT; Vinogradov, SV; Warren, G | 1 |
| Blaha, L; Dott, W; Kovalova, L; Zounkova, R | 1 |
| Alba, L; Antinori, A; Bibas, M; Del Nonno, F; Grisetti, S; Picchi, G | 1 |
| Hu, W; Li, L; Sheng, Y; Shi, J; Su, D; Wang, CK | 1 |
| Barbarat, A; Houlgatte, R; Raharijaona, M; Rolland, D; Thieblemont, C | 1 |
| Bartal, A; Liszkay, G; Mátrai, Z; Szûcs, A | 1 |
| Bonnabry, P; Fleury-Souverain, S; Geiser, L; Hochstrasser, D; Nussbaumer, S; Sadeghipour, F; Veuthey, JL | 1 |
| Adema, AD; Honeywell, RJ; Losekoot, N; Myhren, F; Peters, GJ; Sandvold, ML; Smid, K; Verheul, HM | 1 |
| Fritzer-Szekeres, M; Golakoti, T; Graser, G; Jaeger, W; Krupitza, G; Madlener, S; Saiko, P; Schwarz, S; Somepalli, V; Szekeres, T | 1 |
| Chung, I; Eastman, A; Garner, KM; Montano, R; Parry, D | 1 |
| Campbell, DO; Czernin, J; Lee, JT; Radu, CG; Satyamurthy, N | 1 |
| Botteri, E; Calabrese, L; Cocorocchio, E; Martinelli, G; Peccatori, F; Piperno, G; Preda, L; Travaini, L; Vanazzi, A | 1 |
| Aznar Oroval, E; García-Lozano, T; Juan Bañón, JL; Lorente Alegre, P | 1 |
| Liu, XJ; Nowak, B; Plunkett, W; Wang, YQ | 1 |
| Bocchia, M; Cencini, E; Defina, M; Fabbri, A; Fontanelli, G; Gozzetti, A; Mazzei, MA; Pietrini, A; Volterrani, L | 1 |
| Baker, JA; Dantzig, AH; Guo, Y; Hall, SD; Li, CH; Oluyedun, OA; Qian, YW; Ring, BJ; Wickremsinhe, ER; Wrighton, SA | 1 |
| Annereau, JP; Bailly, C; Bonnet, D; Brel, V; Créancier, L; Currie, E; Fournier, E; Gomes, B; Guilbaud, N; Guminski, Y; Kruczynski, A; Pillon, A; Vandenberghe, I | 1 |
| Altuntaş, F; Bozdağ, SC; Demiriz, IŞ; Durgun, G; Koçubaba, S; Sarıca, A; Tekgündüz, E | 1 |
| Asou, H; Kiyosawa, K; Maeda, K; Takeuchi, K; Taniai, H | 1 |
| Abo, RP; Batzler, A; Fridley, BL; Jenkins, G; Kalari, K; Li, L; Niu, N; Schaid, D; Wang, L | 1 |
| Kato, K | 1 |
| Ciccolini, J; Etienne-Grimaldi, MC; Giovannetti, E; Honeywell, RJ; Losekoot, N; Maulandi, M; Milano, G; Peters, GJ; Serdjebi, C | 1 |
| Hernandez, F; Jaksa, R; Klanova, M; Klener, P; Kulvait, V; Lateckova, L; Lorkova, L; Maswabi, B; Mavis, C; Molinsky, J; Petrak, J; Pospisilova, J; Trneny, M; Vejmelkova, D; Vit, O; Vockova, P; Vokurka, M | 1 |
| Dong, Z; Qin, L; Zhang, JT | 1 |
| Baetz, T; Buckstein, R; Chen, BE; Couban, S; Crump, M; Di Renzo, N; Djurfeldt, MS; Federico, M; Hay, AE; Howson-Jan, K; Imrie, KR; Kaizer, L; Kouroukis, CT; Kukreti, V; Kuruvilla, J; MacDonald, DA; Meyer, RM; Olney, HJ; Rubinger, M; Shepherd, LE; Sussman, J; Turner, AR; Voralia, M | 1 |
| Ashworth, MT; Daud, AI; Freshwater, T; Goldman, JW; Grabowsky, JA; Isaacs, R; Kang, SP; Loechner, S; Mendelson, D; Munster, PN; Parry, D; Rosen, LS; Shanahan, F; Shumway, S; Sorge, C; Springett, G; Strosberg, J; Venook, AP | 1 |
| Terui, Y | 1 |
| Berda, Y; Ciccolini, J; Costello, R; Fanciullino, R; Fina, F; Lacarelle, B; Mercier, C; Ouafik, L; Serdjebi, C | 1 |
| Allegrini, S; Camici, M; Cividini, F; Filoni, DN; Pesi, R; Tozzi, MG | 1 |
| Baetz, T; Chen, BE; Cheung, MC; Couban, S; Crump, M; Desjardins, P; Hassan, S; Hay, AE; Imrie, KR; Kouroukis, CT; Kukreti, V; Le, A; MacDonald, D; Meyer, RM; Mittmann, N; Risebrough, N; Shepherd, L; Song, Y; Sussman, J; Szwajcer, D | 1 |
| Alamoudi, S; Anglin, P; Baetz, T; Chen, BE; Cheung, M; Couban, S; Crump, M; Djurfeldt, MS; Hay, AE; Ismail, WS; Kouroukis, CT; Kuruvilla, J; Luminari, S; MacDonald, DA; Meyer, RM; Olney, HJ; Seftel, M; Shepherd, L; Turner, AR | 1 |
| Brayé, M; Coulibaly, ST; Kretzschmar, FK; Lener, D; Martin, DP; Negroni, M; Rossolillo, P; Winter, F | 1 |
| Chen, CC; Teng, CL; Yeh, SP | 1 |
| Allorge, D; Barthelemy, C; Bonnabry, P; Décaudin, B; Humbert, L; Lebecque, M; Odou, P; Pinturaud, M; Richeval, C; Sidikou, O; Simon, N; Soichot, M; Vasseur, M | 1 |
| Borsky, M; Brychtova, Y; Bryja, V; Collakova, J; Dzimkova, M; Hylse, O; Janovska, P; Jaskova, Z; Kasparkova, M; Kohoutek, J; Oltova, A; Paruch, K; Trbusek, M; Verner, J; Vesely, P; Zaprazna, K; Zemanova, J | 1 |
| Baker, SD; Blum, W; Drenberg, CD; Du, G; Gibson, AA; Gruber, TA; Hu, S; Li, L; Nies, AT; Pabla, N; Pounds, SB; Rhinehart, DP; Schwab, M; Shi, L; Sparreboom, A | 1 |
| Chen, BE; Crump, M; Djurfeldt, M; Good, D; Hay, AE; Kuruvilla, J; Laferriere, N; LeBrun, D; Luminari, S; Meyer, RM; Reiman, T; Savage, KJ; Sehn, LH; Shepherd, LE; Skamene, T; Soulières, D; Stakiw, J; Zhu, L | 1 |
| Alexander, PM; Caudell, DL; Kucera, GL; Pardee, TS; Pladna, KM | 1 |
| Agostoni, V; Couvreur, P; Gref, R; Lampropoulou, M; Lazarou, YG; Maksimenko, A; Rodriguez-Ruiz, V; Salzano, G; Yannakopoulou, K | 1 |
| Fukuda, M; Hosokawa, M; Iwakawa, S; Masuda, A; Tanaka, S; Ueda, K | 1 |
| Eshima, K; Fukushima, M; Iizuka, K; Jin, C; Zhang, C | 1 |
| Ahmed, S; Alousi, A; Anderlini, P; Andersson, BS; Champlin, R; Dabaja, B; Fanale, M; Gulbis, A; Hosing, C; Jones, RB; Kebriaei, P; Ma, J; Milgrom, S; Myers, A; Nieto, Y; Oki, Y; Pinnix, C; Popat, U; Qazilbash, M; Shpall, EJ; Thall, PF; Timmons, M; Valdez, BC | 1 |
| Fujiwara, H; Higuchi, T; Ishino, M; Iwamura, H; Kakinuma, C; Kito, N; Kuniyoshi, H; Matsumoto, T; Mima, S; Nishikawa, H; Paradiso, LJ; Saeki, K; Shimada, Y; Uematsu, R; Yamada, T | 1 |
| Gangangari, KK; Humm, JL; Larson, SM; Pillarsetty, NVK | 1 |
| Aggarwal, AK; Buku, A; Choudhury, JR; Prakash, L; Prakash, S; Rechkoblit, O | 1 |
| Beltran, BE; Conlon, K; Cook, L; Dwyer, K; Feldman, T; Fields, PA; Gonsky, J; Hermine, O; Horwitz, SM; Humphrey, J; Kurman, M; Leoni, M; Moriya, J; Pereira, J; Phillips, AA; Ramos, JC; Sawas, A; Taylor, GP; Wandroo, F | 1 |
| Bradbury, PA; Chan, KK; Chen, BE; Cheung, M; Cheung, WY; Ding, K; Hay, AE; Kornelsen, EA; Leighl, NB; Mittmann, N; Ng, RCH; Pater, JL; Tu, D | 1 |
| Baker, SD; Buelow, DR; Cotton, A; Dang, J; Drenberg, CD; Fu, Q; Gruber, TA; Guy, RK; Hu, S; Inaba, H; Jeon, JY; Li, M; Orwick, SJ; Pioso, M; Ribeiro, RC; Rubnitz, JE; Shelat, A | 1 |
| Acramel, A; Chouquet, T; Goldwirt, L; Jouenne, F; Mourah, S; Plé, A; Sauvageon, H | 1 |
| Arora, R; Hildebrandt, GC; Munker, R; Qasrawi, A; Ramlal, R | 1 |
| Barcinska, E; Inkielewicz-Stepniak, I; Sobczak, K; Steckiewicz, KP; Tomczyk, E; Wojcik, M | 1 |
| Chen, Q; Dong, M; Wu, S; Yang, Z; Zhang, M; Zhang, X | 1 |
| Beijnen, JH; Derissen, EJB | 1 |
| Canonge, JM; Claraz, P; Cretu, Y; Grand, A; Hennebelle, I; Perriat, S; Puisset, F; Riff, I; Vert, C; Wolff, E | 1 |
| Aoki, T; Hayakawa, F; Hikita, T; Iwamoto, E; Kagaya, Y; Kiyoi, H; Kunou, S; Oneyama, C; Sakamoto, A; Sanada, M; Shimada, K; Shimada, S; Takai, M | 1 |
| Huitema, ADR; Otten, HM; Verkerk, K | 1 |
20 review(s) available for cytarabine and deoxycytidine
| Article | Year |
|---|---|
Bromodeoxyuridine mutagenesis and deoxyribonucleotide pool imbalance in mammalian cells.
Topics: Animals; Base Composition; Bromodeoxyuridine; Cell Line; Cricetinae; Cytarabine; Deoxyadenosines; Deoxycytidine; Deoxyguanosine; Deoxyribonucleotides; DNA; Drug Resistance; Fluorouracil; Hydroxyurea; Melanoma; Mutation; Ribonucleotide Reductases; Sister Chromatid Exchange; Thymidine | 1985 |
Resistance of mammalian tumour cells toward pyrimidine analogues. A review.
Topics: Animals; Antimetabolites; Azacitidine; Azauridine; Bromouracil; Carcinoma, Ehrlich Tumor; Cell Line; Cricetinae; Cytarabine; Deoxycytidine; Drug Resistance; Fluorouracil; Genetic Code; Leukemia, Experimental; Leukemia, Lymphoid; Mast-Cell Sarcoma; Mice; Mutation; Neoplasms, Experimental; Oncogenic Viruses; Phosphotransferases; Pyrimidines; Sarcoma, Experimental; Selection, Genetic; Thymidine Kinase; Uracil; Virus Replication | 1973 |
Pyrimidines and their nucleosides.
Topics: Antiviral Agents; Carbohydrates; Chemical Phenomena; Chemistry; Cytarabine; Deoxycytidine; Deoxyuridine; Pyrimidine Nucleosides; Pyrimidines; Trifluridine | 1980 |
[Development of antimetabolites, II].
Topics: Aminopterin; Animals; Antimetabolites, Antineoplastic; Antineoplastic Agents; Cytarabine; Deoxycytidine; Humans; Leukemia L1210; Methotrexate; Mice; Trimetrexate | 1993 |
[Recent development of antitumor antimetabolites in Japan--cytosine arabinoside analogues].
Topics: Animals; Antimetabolites, Antineoplastic; Arabinonucleotides; Carcinoma, Non-Small-Cell Lung; Clinical Trials, Phase I as Topic; Clinical Trials, Phase II as Topic; Cytarabine; Cytidine Monophosphate; Deoxycytidine; Gemcitabine; Humans; Lung Neoplasms; Mice; Neoplasm Transplantation | 1997 |
[Nucleoside kinases and new types of antitumor nucleosides].
Topics: Antimetabolites, Antineoplastic; Cytarabine; Deoxycytidine; Gemcitabine; Humans; Nucleic Acid Synthesis Inhibitors; Phosphotransferases | 1997 |
Chemoprotection against cytosine nucleoside analogs using the human cytidine deaminase gene.
Topics: Antimetabolites, Antineoplastic; Azacitidine; Cytarabine; Cytidine Deaminase; Decitabine; Deoxycytidine; Drug Resistance; Gemcitabine; Humans | 1999 |
Antimetabolites.
Topics: Animals; Antimetabolites, Antineoplastic; Cladribine; Cytarabine; Deoxycytidine; Drug Resistance, Neoplasm; Fluorouracil; Gemcitabine; Humans; Methotrexate | 1999 |
Nucleoside analogues: mechanisms of drug resistance and reversal strategies.
Topics: 2-Chloroadenosine; 5'-Nucleotidase; Acute Disease; Animals; Antimetabolites, Antineoplastic; Arabinonucleosides; Biological Transport; Carrier Proteins; Cytarabine; Cytidine Deaminase; Cytosine; Deoxyadenosines; Deoxycytidine; Deoxycytidine Kinase; Dioxolanes; DNA Repair; DNA Replication; DNA-Directed DNA Polymerase; Drug Resistance, Neoplasm; Gemcitabine; Hematopoietic Cell Growth Factors; Humans; Leukemia, Myeloid; Lymphoproliferative Disorders; Neoplastic Stem Cells; Nucleosides; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor); Remission Induction; Ribonucleotide Reductases; Vidarabine | 2001 |
Nucleoside analogues in the treatment of haematological malignancies.
Topics: Antimetabolites, Antineoplastic; Arabinonucleosides; Biological Transport; Cladribine; Clinical Trials as Topic; Cytarabine; Cytosine; Deoxycytidine; Dioxolanes; Economics, Pharmaceutical; Gemcitabine; Guidelines as Topic; Hematologic Neoplasms; Humans; Molecular Structure; Nucleosides; Pentostatin; Vidarabine | 2001 |
[Clinical pharmacology of nucleoside analogues].
Topics: Antimetabolites; Antimetabolites, Antineoplastic; Biotransformation; Cytarabine; Cytidine Deaminase; DCMP Deaminase; Deoxycytidine; Deoxycytidine Kinase; Female; Gemcitabine; Half-Life; Humans; Male; Metabolic Clearance Rate; Neoplasm Proteins; Phosphorylation; Prodrugs; Vidarabine | 2002 |
The role of membrane transporters in cellular resistance to anticancer nucleoside drugs.
Topics: Antimetabolites, Antineoplastic; Antineoplastic Agents; Biological Transport; Capecitabine; Cell Membrane; Cladribine; Cytarabine; Deoxycytidine; Drug Resistance, Neoplasm; Fluorouracil; Gemcitabine; Humans; Tumor Cells, Cultured; Vidarabine | 2002 |
[Metabolism, mechanism of action and resistance to cytotoxic nucleoside analogues].
Topics: Antimetabolites, Antineoplastic; Apoptosis; Cladribine; Cytarabine; Deoxycytidine; Deoxycytidine Kinase; Drug Resistance, Neoplasm; Gemcitabine; Humans; Nucleoside Transport Proteins; Nucleosides; Phosphorylation; Vidarabine | 2005 |
[Chemotherapy for biliary tract cancers: general remarks].
Topics: Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Biliary Tract Neoplasms; Clinical Trials as Topic; Cytarabine; Deoxycytidine; Doxorubicin; Drug Therapy; Gemcitabine; Humans; Tegafur; Treatment Outcome | 2006 |
[Gemcitabine: from preclinic to clinic passing by pharmacokinetics].
Topics: Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Cytarabine; Deoxycytidine; Gemcitabine | 2007 |
[Main treatment and preventive measures for hand-foot syndrome, a dermatologic side effect of cancer therapy].
Topics: Antineoplastic Agents; Capecitabine; Cytarabine; Deoxycytidine; Docetaxel; Doxorubicin; Fluorouracil; Foot Dermatoses; Hand Dermatoses; Humans; Neoplasms; Peripheral Nervous System; Quality of Life; Severity of Illness Index; Skin; Syndrome; Taxoids | 2011 |
[Chemotherapy using gemcitabine hydrochloride for malignant lymphoma].
Topics: Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Cytarabine; Deoxycytidine; Gemcitabine; Humans; Lymphoma; Practice Guidelines as Topic | 2013 |
[Malignant lymphoma and adult T-cell leukemia-lymphoma].
Topics: Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Cyclophosphamide; Cytarabine; Deoxycytidine; Dexamethasone; Doxorubicin; Etoposide; Genetic Markers; Genetic Testing; Hodgkin Disease; Humans; Leukemia-Lymphoma, Adult T-Cell; Lymphoma, Non-Hodgkin; Methylprednisolone; Positron-Emission Tomography; Prednisone; Vincristine | 2014 |
Relapsed and refractory subcutaneous panniculitis-like T-cell lymphoma with excellent response to cyclosporine: a case report and literature review.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Cyclosporine; Cytarabine; Deoxycytidine; Dexamethasone; Drug Resistance, Neoplasm; Etoposide; Gemcitabine; Humans; Immunosuppressive Agents; Lymphoma, T-Cell, Cutaneous; Male; Methylprednisolone; Multimodal Imaging; Panniculitis; Positron-Emission Tomography; Recurrence; Remission Induction; Salvage Therapy; Skin Neoplasms; Subcutaneous Fat; Tomography, X-Ray Computed | 2016 |
Intracellular Pharmacokinetics of Pyrimidine Analogues used in Oncology and the Correlation with Drug Action.
Topics: Cytarabine; Deoxycytidine; Fluorouracil; Gemcitabine; Humans; Neoplasms; Phosphorylation; Prodrugs; Pyrimidines | 2020 |
14 trial(s) available for cytarabine and deoxycytidine
| Article | Year |
|---|---|
The use of prophylactic eye drops during high-dose cytosine arabinoside therapy.
Topics: Administration, Topical; Cytarabine; Deoxycytidine; Double-Blind Method; Humans; Keratoconjunctivitis; Ophthalmic Solutions; Prednisolone; Prospective Studies | 1992 |
An in vitro method which assesses corneal epithelial toxicity due to antineoplastic, preservative and antimicrobial agents.
Topics: Adult; Aged; Aminoglycosides; Animals; Antineoplastic Agents; Antiviral Agents; Cells, Cultured; Cornea; Cytarabine; Deoxycytidine; Double-Blind Method; Epithelium; Female; Hodgkin Disease; Humans; Keratitis; Leukemia; Male; Middle Aged; Preservatives, Pharmaceutical; Rabbits; Thymidine; Toxicology | 1989 |
Comparison of the prophylactic effects of 2-deoxycytidine and prednisolone for high-dose intravenous cytarabine-induced keratitis.
Topics: Administration, Topical; Adult; Aged; Animals; Clinical Trials as Topic; Cornea; Cytarabine; Deoxycytidine; Double-Blind Method; Female; Humans; Infusions, Intravenous; Keratitis; Male; Middle Aged; Prednisolone; Rabbits; Random Allocation | 1987 |
Phase I study of a continuous infusion of high-dose ara-C in conjunction with a fixed dose of 2'-deoxycytidine (IND 28108) in patients with refractory leukemia: an interim report.
Topics: Adult; Aged; Blast Crisis; Cytarabine; Deoxycytidine; Drug Administration Schedule; Female; Humans; Infusions, Intravenous; Leukemia; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Leukemia, Myeloid, Acute; Male; Middle Aged; Neutropenia; Remission Induction; Thrombocytopenia | 1993 |
A randomized phase III study of gemcitabine, dexamethasone, and cisplatin versus dexamethasone, cytarabine, and cisplatin as salvage chemotherapy followed by posttransplantation rituximab maintenance therapy versus observation for treatment of aggressive
Topics: Antibodies, Monoclonal; Antibodies, Monoclonal, Murine-Derived; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Clinical Trials as Topic; Cytarabine; Deoxycytidine; Dexamethasone; Gemcitabine; Humans; Lymphoma, B-Cell; Lymphoma, T-Cell; Rituximab | 2005 |
Evaluation of early DNA damage in healthcare workers handling antineoplastic drugs.
Topics: Adult; Analysis of Variance; Antineoplastic Agents; Biomarkers; Cancer Care Facilities; Comet Assay; Cyclophosphamide; Cytarabine; Deoxycytidine; DNA Damage; Environmental Monitoring; Epidemiological Monitoring; Female; Fluorouracil; Gemcitabine; Humans; Ifosfamide; Italy; Lymphocytes; Male; Middle Aged; Mouth Mucosa; Nursing Staff, Hospital; Occupational Exposure; Pharmacy Service, Hospital | 2006 |
Phase I study of preoperative short-course chemoradiation with proton beam therapy and capecitabine for resectable pancreatic ductal adenocarcinoma of the head.
Topics: Aged; Aged, 80 and over; Capecitabine; Carcinoma, Pancreatic Ductal; Combined Modality Therapy; Cytarabine; Deoxycytidine; Feasibility Studies; Female; Fluorouracil; Humans; Length of Stay; Male; Middle Aged; Pancreatic Neoplasms; Pancreaticoduodenectomy; Prescriptions; Prospective Studies; Proton Therapy; Radiography; Radiotherapy Dosage; Radiotherapy Planning, Computer-Assisted | 2011 |
Clinical study of adjuvant capecitabine monotherapy in Chinese elderly patients (aged 55-70) with stage IIa breast cancer.
Topics: Administration, Oral; Aged; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Capecitabine; China; Cyclophosphamide; Cytarabine; Deoxycytidine; Epirubicin; Female; Fluorouracil; Humans; Middle Aged; Neoplasm Staging; Treatment Outcome | 2010 |
Randomized comparison of gemcitabine, dexamethasone, and cisplatin versus dexamethasone, cytarabine, and cisplatin chemotherapy before autologous stem-cell transplantation for relapsed and refractory aggressive lymphomas: NCIC-CTG LY.12.
Topics: Adolescent; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Cytarabine; Deoxycytidine; Dexamethasone; Female; Hematopoietic Stem Cell Transplantation; Humans; Lymphoma; Male; Middle Aged; Quality of Life; Survival Rate; Transplantation, Autologous; Treatment Outcome | 2014 |
Phase I dose-escalation trial of checkpoint kinase 1 inhibitor MK-8776 as monotherapy and in combination with gemcitabine in patients with advanced solid tumors.
Topics: Adenocarcinoma; Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Checkpoint Kinase 1; Cohort Studies; Cytarabine; Deoxycytidine; Female; Gemcitabine; Histones; Humans; Infusions, Intravenous; K562 Cells; Male; Melanoma; Middle Aged; Neoplasms; Protein Kinase Inhibitors; Protein Kinases; Pyrazoles; Pyrimidines; Sarcoma; Time Factors | 2015 |
Salvage chemotherapy and autologous stem cell transplantation for transformed indolent lymphoma: a subset analysis of NCIC CTG LY12.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Cytarabine; Deoxycytidine; Dexamethasone; Etoposide; Female; Follow-Up Studies; Gemcitabine; Hematopoietic Stem Cell Transplantation; Humans; Lymphoma, Large B-Cell, Diffuse; Lymphoma, Non-Hodgkin; Male; Middle Aged; Multivariate Analysis; Prognosis; Recurrence; Salvage Therapy; Survival Analysis; Time Factors; Transplantation, Autologous | 2015 |
Salvage chemotherapy and autologous stem cell transplantation for peripheral T-cell lymphoma: a subset analysis of the Canadian Cancer Trials Group LY.12 randomized phase 3 study
Topics: Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Cytarabine; Deoxycytidine; Gemcitabine; Hematopoietic Stem Cell Transplantation; Humans; Lymphoma, T-Cell, Peripheral; Salvage Therapy; Transplantation, Autologous | 2017 |
Phase II Trial of High-Dose Gemcitabine/Busulfan/Melphalan with Autologous Stem Cell Transplantation for Primary Refractory or Poor-Risk Relapsed Hodgkin Lymphoma.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Busulfan; Carmustine; Cytarabine; Deoxycytidine; Etoposide; Gemcitabine; Hematopoietic Stem Cell Transplantation; Hodgkin Disease; Humans; Melphalan; Middle Aged; Salvage Therapy; Survival Analysis; Transplantation, Autologous; Young Adult | 2018 |
Mogamulizumab
Topics: Adult; Aged; Aged, 80 and over; Aminopterin; Antibodies, Monoclonal, Humanized; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Cytarabine; Deoxycytidine; Dexamethasone; Drug Resistance, Neoplasm; Female; Follow-Up Studies; Gemcitabine; Humans; International Agencies; Leukemia-Lymphoma, Adult T-Cell; Male; Middle Aged; Neoplasm Recurrence, Local; Oxaliplatin; Prognosis; Retrospective Studies; Salvage Therapy; Survival Rate; Young Adult | 2019 |
263 other study(ies) available for cytarabine and deoxycytidine
| Article | Year |
|---|---|
Synthesis and biological activities of some uronic acids, uronates, uronamides, and urononitriles of pyrimidine nucleosides.
Topics: Animals; Cell Division; Cells, Cultured; Chick Embryo; Pyrimidine Nucleosides; Sarcoma 180; Simplexvirus; Streptococcus; Structure-Activity Relationship; Substrate Specificity; Thymidine Kinase; Thymidylate Synthase; Uronic Acids; Virus Replication | 1978 |
Acetylenic nucleosides. 4. 1-beta-D-arabinofuranosyl-5-ethynylcytosine. Improved synthesis and evaluation of biochemical and antiviral properties.
Topics: Antiviral Agents; Cytarabine; Deamination; Phosphorylation; Simplexvirus | 1987 |
Synthesis and antitumor activity of fluorine-substituted 4-amino-2(1H)-pyridinones and their nucleosides. 3-Deazacytosines.
Topics: Animals; Antimetabolites, Antineoplastic; Cytosine; Drug Evaluation, Preclinical; Indicators and Reagents; Leukemia L1210; Magnetic Resonance Spectroscopy; Mass Spectrometry; Mice; Spectrophotometry; Structure-Activity Relationship | 1987 |
2'-O-nitro-1-beta-D-arabinofuranosylcytosine. A new derivative of 1-beta-D-arabinofuranosylcytosine that resists enzymatic deamination and has antileukemic activity.
Topics: Animals; Antimetabolites, Antineoplastic; Cytarabine; Drug Evaluation, Preclinical; Female; Leukemia L1210; Mice; Mice, Inbred Strains | 1983 |
Deoxyribonucleoside kinases activate nucleoside antibiotics in severely pathogenic bacteria.
Topics: Animals; Anti-Bacterial Agents; Deoxycytidine; Female; Gemcitabine; Humans; Mice; Mice, Inbred BALB C; Microbial Sensitivity Tests; Molecular Sequence Data; Nucleosides; Phosphotransferases (Alcohol Group Acceptor); Staphylococcal Infections; Staphylococcus aureus; Streptococcal Infections; Streptococcus pyogenes | 2007 |
Comparison of enzymatic activities of two deoxycytidine kinases purified from cells sensitive (P815) or resistant (P815/ara-C) to 1-beta-D-arabinofuranosylcytosine.
Topics: Animals; Cytarabine; Deoxycytidine; Drug Resistance; Hydrogen-Ion Concentration; In Vitro Techniques; Isoenzymes; Kinetics; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Neoplasms, Experimental; Phosphotransferases; Substrate Specificity; Temperature | 1978 |
Effects of cytosine arabinoside on the incorporation of pyrimidine nucleosides into hamster cells transformed by herpes simplex type 1 and type 2 viruses and by human cytomegalovirus.
Topics: Animals; Cell Line; Cell Transformation, Viral; Cricetinae; Cytarabine; Cytomegalovirus; Deoxycytidine; Humans; Phosphorylation; Pyrimidine Nucleosides; Simplexvirus; Thymidine | 1979 |
Cellular phosphorylation of 1-beta-D-arabinofuranosylcytosine 5-azacytidine with intact fibrosarcoma and leukemic cells.
Topics: Animals; Azacitidine; Binding, Competitive; Cells, Cultured; Cricetinae; Cytarabine; Cytidine; Deoxycytidine; Drug Resistance; Fibrosarcoma; Kinetics; Leukemia, Experimental; Mice; Phosphorus; Sarcoma, Experimental | 1975 |
Deoxycytidine kinase: properties of the enzyme from human leukemic granulocytes.
Topics: Azacitidine; Blood Proteins; Cell Separation; Cell-Free System; Cytarabine; Cytidine Deaminase; Deoxycytidine; Granulocytes; Humans; Leukemia; Leukemia, Myeloid; Leukemia, Myeloid, Acute; Leukocytes; Molecular Weight; Phosphates; Phosphotransferases; Tissue Extracts; Uridine Kinase | 1975 |
Deoxycytidine and lethal doses of cytarabine in advanced murine leukaemia.
Topics: Administration, Oral; Animals; Cytarabine; Deoxycytidine; Drug Antagonism; Drug Therapy, Combination; Female; Injections, Intraperitoneal; Leukemia L1210; Leukemia, Lymphoid; Leukemia, Myeloid, Acute; Male; Mice | 1977 |
Increased urinary excretion of nucleic acid and nicotinamide derivatives by rats after treatment with alkylating agents.
Topics: 2-Acetylaminofluorene; Alkylating Agents; Animals; Benz(a)Anthracenes; Busulfan; Chromatography, Thin Layer; Cytarabine; Deoxycytidine; Dichlorvos; Dimethylnitrosamine; Ethyl Methanesulfonate; Female; Fluorouracil; Hydrocarbons, Brominated; Mechlorethamine; Methylguanidine; Niacinamide; Nitrosourea Compounds; Rats; Thymidine; Uric Acid | 1975 |
Effects of 5-fluorodeoxyuridine on cell viability and uptake of deoxycytidine and (3H)cytosine arabinoside in L5178Y cells.
Topics: Animals; Cells, Cultured; Cytarabine; Deoxycytidine; DNA; Floxuridine; Kinetics; Leukemia; Mice; RNA | 1976 |
Stability of simian virus 40 (SV40) mRNA species.
Topics: Cell Line; Cytarabine; Deoxycytidine; DNA, Viral; Nucleic Acid Hybridization; Polyribosomes; RNA, Messenger; RNA, Viral; Simian virus 40; Time Factors | 1975 |
Studies on mechanisms of resistance to cytosine arabinoside: problems in the determination of related enzyme activities in leukemic cells.
Topics: Bone Marrow; Bone Marrow Cells; Cytarabine; Cytidine Deaminase; Deoxycytidine; Drug Resistance; Erythrocytes; Granulocytes; Humans; Kinetics; Leukemia, Myeloid; Leukemia, Myeloid, Acute; Nucleoside Deaminases; Phosphotransferases; Tetrahydrouridine | 1975 |
The mechanism of action of 3-deazauridine in tumor cells sensitive and resistant to arabinosylcytosine.
Topics: 3-Deazauridine; Adenocarcinoma; Animals; Cell Line; Cytarabine; Deoxycytidine; Deoxyribonucleotides; DNA, Neoplasm; Drug Resistance; Leukemia L1210; Liver; Mice; Neoplasms, Experimental; Orotic Acid; Phosphotransferases; Pyrimidine Nucleotides; Ribonucleotide Reductases; Ribonucleotides; RNA, Neoplasm; Uracil Nucleotides; Uridine | 1975 |
Tubuloreticular structures in human lymphoid cell lines. A cell biological study.
Topics: Antigens, Viral; Bromodeoxyuridine; Cell Line; Cells, Cultured; Cytarabine; Deoxycytidine; DNA; Herpesvirus 4, Human; Humans; Inclusion Bodies; Lymphocytes; Temperature; Thymidine | 1975 |
Physiologic disposition of cytosine arabinoside and its derivatives in man.
Topics: Administration, Oral; Cytarabine; Deamination; Deoxycytidine; Humans; In Vitro Techniques; Injections, Intravenous; Neoplasms, Experimental; Phosphotransferases; Time Factors | 1977 |
Transport and metabolism of deoxycytidine and 1-beta-D-arabinofuranosylcytosine into cultured Novikoff rat hepatoma cells, relationship to phosphorylation, and regulation of triphosphate synthesis.
Topics: Animals; Biological Transport, Active; Carcinoma, Hepatocellular; Cells, Cultured; Cytarabine; Deoxycytidine; Deoxyribonucleotides; DNA, Neoplasm; Feedback; Hydroxyurea; Liver Neoplasms; Neoplasms, Experimental; Oxidative Phosphorylation; Rats; Thymidine | 1978 |
[Selective treatment of leukemia L1210 with combination of deoxycytidine and lethal doses of cytosine arabinoside].
Topics: Administration, Oral; Animals; Cytarabine; Deoxycytidine; Drug Evaluation; Drug Therapy, Combination; Injections, Intraperitoneal; Leukemia L1210; Leukemia, Lymphoid; Leukemia, Myeloid, Acute; Mice | 1978 |
[Selective inhibition of the primary humoral immune response in mice with a combination of deoxycytidine with Cytosar].
Topics: Animals; Antibody Formation; Cytarabine; Deoxycytidine; Dose-Response Relationship, Immunologic; Drug Combinations; Female; Hemagglutinins; Immunization; Immunosuppressive Agents; Mathematics; Mice; Mice, Inbred C57BL | 1979 |
Inhibition of DNA excision repair in human cells by arabinofuranosyl cytosine: effect on normal and xeroderma pigmentosum cells.
Topics: Cytarabine; Deoxycytidine; DNA Repair; Humans; In Vitro Techniques; Ultraviolet Rays; Xeroderma Pigmentosum | 1979 |
2'-Deoxycytidine hydrochloride protection of mice against the lethal toxicity of cytosine arabinoside. Absence of protection of bone marrow lymphocytes.
Topics: Animals; Antibody Formation; Bone Marrow; Bone Marrow Cells; Cytarabine; Deoxycytidine; Female; Immunity, Cellular; Leukemia L1210; Lymphocytes; Male; Mice; Mice, Inbred Strains; Time Factors | 1979 |
Effect of cytosine arabinoside triphosphate on the incorporation of 3H-thymidine in mitochondria isolated from HeLa cells.
Topics: Arabinofuranosylcytosine Triphosphate; Arabinonucleotides; Cell-Free System; Cytarabine; Deoxycytidine; DNA, Mitochondrial; DNA, Neoplasm; Ethidium; HeLa Cells; Humans; Mitochondria; Thymidine | 1979 |
Structural comparison of deoxycytidine kinases purified from cells sensitive (P815) or resistant (P815/ara-C) to 1-beta-D-arabinofuranosylcytosine.
Topics: Amino Acids; Animals; Chloromercuribenzoates; Cyanogen Bromide; Cytarabine; Deoxycytidine; Drug Resistance; Isoenzymes; Mice; Molecular Weight; Neoplasms, Experimental; Phosphotransferases; Structure-Activity Relationship | 1978 |
Deoxycytidine kinase and cytosine nucleoside deaminase activities in synchronized cultures of normal rat kidney cells.
Topics: Cell Cycle; Cell Survival; Cells, Cultured; Cytarabine; Cytidine; Cytosine; Deoxycytidine; Nucleoside Deaminases; Phosphotransferases; Substrate Specificity | 1978 |
[Protection of the mouse digestive tract from the toxic effect of cytosine-arabinoside].
Topics: Animals; Cytarabine; Deoxycytidine; Digestive System; Drug Combinations; Drug Interactions; Female; Mice; Mice, Inbred C57BL; Suspensions; Time Factors | 1977 |
Selective chemotherapy for advanced murine L 1210 leukemia by combination of 2' deoxycytidine and lethal doses of cytosine-arabinoside.
Topics: Animals; Cytarabine; Deoxycytidine; Dose-Response Relationship, Drug; Drug Interactions; Drug Therapy, Combination; Female; Leukemia L1210; Male; Mice | 1977 |
Plasma half-life of cytosine arabinoside in patients with leukaemia--the effect of uridine.
Topics: Administration, Oral; Aminohydrolases; Animals; Cell Count; Cytarabine; Deoxycytidine; DNA, Neoplasm; Dose-Response Relationship, Drug; Half-Life; Humans; Leukemia L1210; Leukemia, Myeloid; Leukocytes; Mice; Uridine | 1975 |
Influence of tetrahydrouridine on the phosphorylation of 1-beta-D-arabinofuranosyl-cytosine (ara-C) by enzymes from solid tumors in vitro.
Topics: Adenocarcinoma; Animals; Bone Neoplasms; Cytarabine; Cytidine Deaminase; Deoxycytidine; Female; In Vitro Techniques; Kinetics; L Cells; Liver; Lung Neoplasms; Male; Mice; Neoplasm Transplantation; Neoplasms, Experimental; Osteosarcoma; Phosphorus; Phosphotransferases; Sarcoma 180; Spleen; Tetrahydrouridine; Uridine | 1975 |
Occurrence of deaminated monophosphate nucleotide in extracellular sites after giving arabinofuranosylcytosine or deoxycytidine to mice.
Topics: Animals; Blood Platelets; Cytarabine; Deoxycytidine; Intestine, Small; Leukemia L1210; Leukocytes; Liver; Mice; Myocardium; Nucleosides; Nucleotides; Spleen; Thymus Gland | 1975 |
Alkylated cytosine nucleosides: substrate and inhibitor properties in enzymatic deamination.
Topics: Alkylation; Chemical Phenomena; Chemistry; Chromatography; Chromatography, Paper; Cytarabine; Cytidine; Cytidine Deaminase; Deoxycytidine; Kinetics; Nucleoside Deaminases; Pyrimidines; Salmonella typhimurium | 1975 |
Mechanisms of action of 6-thioguanine, 6-mercaptopurine, and 8-azaguanine.
Topics: Azaguanine; Azauridine; Carcinoma, Squamous Cell; Cell Line; Cell Survival; Cytarabine; Deoxycytidine; DNA, Neoplasm; Guanine; Hypoxanthines; Imidazoles; Mercaptopurine; Methylthioinosine; Purines; RNA, Neoplasm; Thioguanine; Thymidine | 1975 |
Cytosine arabinoside uptake by tumour cells in vitro.
Topics: Animals; Cytarabine; Deoxycytidine; Diffusion; Female; In Vitro Techniques; Kinetics; Leukemia L1210; Leukemia, Experimental; Neoplasms, Experimental; Rats; Sarcoma, Yoshida | 1975 |
[DNA and protein synthesis in cultured lens epithelial cells. II. Activity of synthetic effectors].
Topics: Animals; Antimetabolites; Cattle; Cells, Cultured; Crystallins; Cytarabine; Dactinomycin; Deoxycytidine; DNA; Epithelial Cells; Epithelium; Lens, Crystalline; Puromycin; RNA, Messenger | 1975 |
A human-mouse somatic hybrid line selected for human deoxycytidine deaminase.
Topics: Aminopterin; Animals; Bromodeoxycytidine; Chromosome Mapping; Chromosomes; Culture Media; Cytarabine; Deoxycytidine; Fibroblasts; Humans; Hybrid Cells; Hypoxanthines; In Vitro Techniques; Isoenzymes; Mice; Mutation; Nucleoside Deaminases | 1975 |
Inhibition of intracellular pyrimidine ribonucleotide reduction by deoxycytidine, arabinosylcytosine and hydroxyurea.
Topics: Cell Line; Cytarabine; Deoxycytidine; Hydroxyurea; Oxidation-Reduction; Pyrimidine Nucleotides; Uridine | 1976 |
Cytarabine: cytocidal effect on normal and leukemic lymphocytes. Synergism with x rays and comparison with mechlorethamine.
Topics: Cytarabine; Deoxycytidine; Humans; Leukemia, Lymphoid; Lymphocytes; Mechlorethamine; Radiation Effects; Temperature | 1976 |
The role of deoxycytidine-metabolizing enzymes in the cytotoxicity induced by 3'-amino-2',3'-dideoxycytidine and cytosine arabinoside.
Topics: Animals; Antineoplastic Agents; Cell Count; Cell Division; Cytarabine; Cytidine Deaminase; Deoxycytidine; HeLa Cells; Humans; Leukemia L1210; Mice; Nucleoside Deaminases; Sensitivity and Specificity; Tumor Cells, Cultured; Zalcitabine | 1992 |
Compartmentation of dCTP pools disappears after hydroxyurea or araC treatment in lymphocytes.
Topics: Cytarabine; Deoxycytidine; Deoxycytosine Nucleotides; DNA; G1 Phase; Humans; Hydroxyurea; Lymphocytes; Palatine Tonsil; Phospholipids; S Phase; Thymidine | 1992 |
[Pharmacokinetic studies of dFdC (2',2'-difluorodeoxycytidine), ara-C and BH-AC (N4-behenoyl ara-C) in experimental animals].
Topics: Animals; Antimetabolites, Antineoplastic; Antineoplastic Agents; Cytarabine; Deoxycytidine; Gemcitabine; Half-Life; Liver; Mice; Rabbits; Sarcoma, Experimental | 1992 |
Deoxycytidine protects normal bone marrow progenitors against Ara-C and gemcitabine cytotoxicity without compromising their activity against cisplatin-resistant human ovarian cancer cells.
Topics: Antimetabolites, Antineoplastic; Blotting, Western; Bone Marrow Cells; Cisplatin; Cystadenocarcinoma; Cytarabine; Deoxycytidine; Dose-Response Relationship, Drug; Female; Gemcitabine; Glutathione Transferase; Humans; Injections, Intraperitoneal; Injections, Intravenous; Ovarian Neoplasms; RNA, Messenger; Stem Cells; Tumor Cells, Cultured | 1992 |
Synthesis and anticancer and antiviral activities of various 2'- and 3'-methylidene-substituted nucleoside analogues and crystal structure of 2'-deoxy-2'-methylidenecytidine hydrochloride.
Topics: Animals; Antineoplastic Agents; Antiviral Agents; Chemical Phenomena; Chemistry; Crystallization; Cytarabine; Deoxycytidine; Female; Humans; Leukemia L1210; Leukemia P388; Leukemia, Lymphoid; Mice; Molecular Structure; Nucleosides; Sarcoma 180; Simplexvirus; Tumor Cells, Cultured; X-Ray Diffraction | 1991 |
[Clinical application of enzyme inhibitors--hematologic malignancies].
Topics: Cytarabine; Deoxycytidine; DNA Topoisomerases, Type I; Etoposide; Gemcitabine; Humans; Leukemia; Mercaptopurine; Methotrexate; Purines; Pyrimidines; Thioguanine; Topoisomerase I Inhibitors | 1991 |
Particular characteristics of the anti-human cytomegalovirus activity of (S)-1-(3-hydroxy-2-phosphonylmethoxypropyl)cytosine (HPMPC) in vitro.
Topics: Animals; Antiviral Agents; Cidofovir; Cytarabine; Cytidine; Cytomegalovirus; Cytosine; Deoxycytidine; DNA, Viral; Ganciclovir; Humans; Organophosphonates; Organophosphorus Compounds; Tumor Cells, Cultured; Virus Replication | 1991 |
Cytosine arabinoside kills postmitotic neurons in a fashion resembling trophic factor deprivation: evidence that a deoxycytidine-dependent process may be required for nerve growth factor signal transduction.
Topics: Animals; Antineoplastic Agents; Cell Survival; Cells, Cultured; Cytarabine; Deoxycytidine; Mitosis; Nerve Growth Factors; Nerve Tissue Proteins; Neurons; Neurotoxins; RNA; Signal Transduction; Sympathetic Nervous System | 1990 |
Induction of deoxycytidine kinase by 5-azacytidine in an HL-60 cell line resistant to arabinosylcytosine.
Topics: Azacitidine; Base Sequence; Cytarabine; Deoxycytidine; Deoxycytidine Kinase; DNA, Neoplasm; Drug Resistance; Enzyme Induction; Humans; Kinetics; Leukemia, Experimental; Leukemia, Myeloid; Methylation; Molecular Sequence Data; Time Factors; Tritium; Tumor Cells, Cultured | 1991 |
Broad-spectrum antiviral and cytocidal activity of cyclopentenylcytosine, a carbocyclic nucleoside targeted at CTP synthetase.
Topics: Adenosine; Amides; Antiviral Agents; Azauridine; Carbon-Nitrogen Ligases; Cell Division; Cytarabine; Cytidine; Deoxycytidine; Drug Synergism; Fluorouracil; HeLa Cells; Humans; Ligases; Nucleosides; Pyrazoles; Ribavirin; Ribonucleosides; Ribose; Thymidine; Tumor Cells, Cultured; Uracil; Virus Replication; Viruses | 1991 |
Action of 2',2'-difluorodeoxycytidine on DNA synthesis.
Topics: Antimetabolites, Antineoplastic; Base Sequence; Cells, Cultured; Cytarabine; Deoxycytidine; Deoxycytidine Monophosphate; Deoxycytosine Nucleotides; DNA; Gemcitabine; Humans; Molecular Sequence Data; RNA | 1991 |
Use of plasma cytotoxic activity to model cytotoxic pharmacodynamics of anticancer drugs.
Topics: Adult; Aged; Cytarabine; Daunorubicin; Deoxycytidine; Female; Humans; Leukemia, Myeloid, Acute; Leukemia, Promyelocytic, Acute; Male; Middle Aged; Tumor Cells, Cultured | 1991 |
The impact of selected nucleosides on the cytotoxicity of Ara-C in HL60 cells.
Topics: Cell Line; Cell Survival; Cytarabine; Cytidine; Deoxyadenosines; Deoxycytidine; Deoxyguanosine; Drug Interactions; Humans; Kinetics; Leukemia, Promyelocytic, Acute; Nucleosides; Tetrahydrouridine; Uridine | 1991 |
Comparison of antineoplastic activity of 2',2'-difluorodeoxycytidine and cytosine arabinoside against human myeloid and lymphoid leukemic cells.
Topics: Antimetabolites, Antineoplastic; Cell Division; Cytarabine; Deoxycytidine; DNA, Neoplasm; Gemcitabine; Humans; Kinetics; Leukemia, Experimental; Leukemia, Lymphoid; Leukemia, Myeloid; Phenotype; Tumor Cells, Cultured | 1991 |
Deoxycytidine is salvaged not only into DNA but also into phospholipid precursors. III. dCOP-diacylglycerol formation in tonsillar lymphocytes.
Topics: Chlorpromazine; Chromatography, Thin Layer; Cytarabine; Cytidine Diphosphate Diglycerides; Deoxycytidine; DNA; Humans; Infant; Kinetics; Lymphocytes; Palatine Tonsil; Phosphatidylinositols; Thymidine | 1991 |
Antitumor activity of 2'-deoxy-2'-methylidenecytidine, a new 2'-deoxycytidine derivative.
Topics: Animals; Cytarabine; Deoxycytidine; Drug Administration Schedule; Drug Screening Assays, Antitumor; Female; Humans; Leukemia P388; Male; Melanoma; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Inbred DBA; Neoplasms; Tumor Cells, Cultured | 1991 |
Effect of tetrahydrouridine and deoxytetrahydrouridine on the interaction between 2'-deoxycytidine and 1-beta-D-arabinofuranosylcytosine in human leukemia cells.
Topics: Arabinofuranosylcytosine Triphosphate; Cell Division; Cytarabine; Cytidine Deaminase; DCMP Deaminase; Deamination; Deoxycytidine; Deoxycytosine Nucleotides; DNA, Neoplasm; Humans; Leukemia; Tetrahydrouridine; Tumor Cells, Cultured | 1991 |
The effect of a prolonged in vitro exposure to 1-beta-D arabinofuranosylcytosine and deoxycytidine on the survival of normal (CFU-GM) and leukemic (L-CFU) human myeloid progenitor cells in suspension culture.
Topics: Cell Survival; Culture Media; Cyclophosphamide; Cytarabine; Deoxycytidine; Hematopoietic Stem Cells; Humans; Leukemia, Myeloid; Neoplastic Stem Cells; Phytohemagglutinins; Suspensions; Tumor Cells, Cultured | 1990 |
Selective eradication of leukemic (L-CFU) versus normal (CFU-GM) myeloid progenitors in suspension culture utilizing a prolonged exposure to 1-B-D arabinofuranosylcytosine (Ara-C) and deoxycytidine (dCyd).
Topics: Antineoplastic Combined Chemotherapy Protocols; Cell Separation; Cells, Cultured; Cytarabine; Deoxycytidine; Granulocytes; Humans; Leukemia, Myeloid, Acute; Macrophages; Neoplastic Stem Cells; Stem Cells; Tumor Cells, Cultured | 1990 |
Modulatory activity of 2',2'-difluorodeoxycytidine on the phosphorylation and cytotoxicity of arabinosyl nucleosides.
Topics: Arabinonucleosides; Arabinonucleotides; Cytarabine; Deoxycytidine; Gemcitabine; Humans; Leukemia; Phosphorylation; Tumor Cells, Cultured; Vidarabine | 1990 |
Interaction of deoxycytidine and deoxycytidine analogs in normal and leukemic human myeloid progenitor cells.
Topics: Azacitidine; Cell Division; Cell Line; Colony-Forming Units Assay; Cytarabine; Decitabine; Deoxycytidine; Hematopoietic Stem Cells; Humans; Leukemia, Myeloid, Acute | 1986 |
Differential modulation of 1-beta-D-arabinofuranosylcytosine metabolism by hydroxyurea in human leukemic cell lines.
Topics: Arabinofuranosylcytosine Triphosphate; Arabinonucleotides; B-Lymphocytes; Cell Line; Cytarabine; Deoxyadenine Nucleotides; Deoxyadenosines; Deoxycytidine; Deoxycytosine Nucleotides; Humans; Hydroxyurea; Leukemia; T-Lymphocytes; Thymine Nucleotides; Vidarabine Phosphate | 1988 |
Reduction of ara-C cytotoxicity in HL 60 cells by addition of deoxycytidine, cytidine or increased level of cytidine deaminase.
Topics: Bone Marrow; Bone Marrow Cells; Cell Division; Cytarabine; Cytidine; Cytidine Deaminase; Deoxycytidine; Deoxycytidine Kinase; Humans; Leukemia, Promyelocytic, Acute; Nucleoside Deaminases; Phosphotransferases; Tetrahydrouridine; Tretinoin; Tumor Cells, Cultured | 1989 |
Ara-CTP metabolism following hydroxyurea or methotrexate treatment in human leukemia cell lines.
Topics: Arabinofuranosylcytosine Triphosphate; Arabinonucleotides; Cytarabine; Deoxycytidine; Deoxycytosine Nucleotides; Drug Synergism; Humans; Hydroxyurea; Leukemia; Leukemia, Promyelocytic, Acute; Methotrexate; Thymine Nucleotides; Tumor Cells, Cultured | 1989 |
[Relationship between Ara-C sensitivity of leukemic-colony forming units (L-CFU) and [3H] deoxycytidine suicide test of L-CFU].
Topics: Adult; Aged; Cell Survival; Cytarabine; Deoxycytidine; Female; Humans; Leukemia; Male; Middle Aged; Neoplastic Stem Cells; Thymidine; Tritium; Tumor Stem Cell Assay | 1989 |
Cytosine arabinoside kills postmitotic neurons: evidence that deoxycytidine may have a role in neuronal survival that is independent of DNA synthesis.
Topics: Animals; Antineoplastic Agents; Cell Survival; Chick Embryo; Ciliary Body; Cytarabine; Deoxycytidine; DNA; Dose-Response Relationship, Drug; Ganglia, Spinal; Insulin; Mitosis; Nerve Growth Factors; Neurons; Parasympathetic Nervous System; Thioinosine | 1989 |
Modulation of deoxynucleotide metabolism by the deoxycytidylate deaminase inhibitor 3,4,5,6-tetrahydrodeoxyuridine.
Topics: Cell Line; Cytarabine; Cytidine Diphosphate; DCMP Deaminase; Deoxycytidine; Deoxycytidine Kinase; Deoxycytosine Nucleotides; Deoxyuridine; Hydroxyurea; Kinetics; Nucleotide Deaminases; Ribonucleotide Reductases; T-Lymphocytes; Tetrahydrouridine; Thymine Nucleotides | 1989 |
Deoxycytidine is salvaged not only into DNA but also into phospholipid precursors. II. Ara-C does not inhibit the later process in lymphoid cells.
Topics: AraC Transcription Factor; Bacterial Proteins; Choline; Cytarabine; Deoxycytidine; DNA; Humans; Infant; Lymphoid Tissue; Lymphoma; Phospholipids; Repressor Proteins; Thymidine; Transcription Factors; Tumor Cells, Cultured | 1989 |
5-fluorodeoxyuridine decreases the effect of arabinofuranosyl-cytosine in undifferentiated human B lymphocytes.
Topics: B-Lymphocytes; Centrifugation, Density Gradient; Child, Preschool; Cytarabine; Deoxycytidine; DNA; Floxuridine; Humans; T-Lymphocytes; Thymidine; Tritium | 1988 |
The effect of 2'-fluoro-2'-deoxycytidine on herpes virus growth.
Topics: Animals; Cell Division; Cricetinae; Cytarabine; Cytidine; Deoxycytidine; Herpesvirus 1, Equid; Herpesvirus 1, Suid; Humans; Phosphorylation; Simplexvirus; Thymidine Kinase | 1985 |
Carbocyclic analogues of 5-halocytosine nucleosides.
Topics: Bromodeoxycytidine; Chemical Phenomena; Chemistry; Cytarabine; Cytidine; Deoxycytidine; Halogens; Simplexvirus; Virus Replication | 1986 |
Qualitative differences between replicative and repair synthesis of DNA in normal and transformed mouse cells as measured by precursor discrimination.
Topics: Animals; Aphidicolin; Bromodeoxyuridine; Cell Line; Cell Transformation, Neoplastic; Chromosome Aberrations; Cytarabine; Deoxycytidine; Diterpenes; DNA; DNA Damage; DNA Polymerase II; DNA Repair; DNA Replication; Embryo, Mammalian; Mice; Substrate Specificity; Ultraviolet Rays | 1986 |
[Effect of cytosine arabinoside on the cell cycle and level of radiation-induced chromosome anomalies in lymphocytes of mammals].
Topics: Animals; Cell Cycle; Chromosome Aberrations; Cytarabine; Deoxycytidine; Humans; Lymphocyte Activation; Lymphocytes; Rabbits; Swine; Time Factors | 1985 |
Design, synthesis, and antineoplastic activity of 2'-deoxy-2'-methylidenecytidine.
Topics: Antineoplastic Agents; Cytarabine; Deoxycytidine; Fluorouracil; Humans; Tumor Cells, Cultured | 1988 |
Comparison of the cellular pharmacokinetics and toxicity of 2',2'-difluorodeoxycytidine and 1-beta-D-arabinofuranosylcytosine.
Topics: Animals; Arabinofuranosylcytosine Triphosphate; Cell Line; Cell Survival; Clone Cells; Cytarabine; Deoxycytidine; Deoxycytidine Kinase; DNA Replication; Drug Evaluation, Preclinical; Gemcitabine; Kinetics | 1988 |
Examination of the photokinetics of 1-beta-D-arabinofuranosylcytosine and deoxyribocytidine.
Topics: Cytarabine; Deoxycytidine; Kinetics; Photochemistry; Ultraviolet Rays | 1988 |
Deamination rates of 1-beta-D-arabinofuranosylcytosine, deoxycytidine and 5-methyl-2'-deoxycytidine in seven hematopoietic cell lines.
Topics: Animals; Cell Line; Cytarabine; Cytidine Deaminase; Deamination; Deoxycytidine; Hematopoietic Stem Cells; Humans; Leukemia, Experimental; Nucleoside Deaminases; Sonication | 1987 |
N4-chloroacetylcytosine arabinoside--a possible pro-drug of cytosine arabinoside.
Topics: Animals; Cell Line; Cell Survival; Cricetinae; Cytarabine; Deoxycytidine; Drug-Related Side Effects and Adverse Reactions; Fibrosarcoma; Prodrugs; Sarcoma, Experimental | 1987 |
Deoxycytidine preferentially protects normal versus leukemic myeloid progenitor cells from cytosine arabinoside-mediated cytotoxicity.
Topics: Antineoplastic Agents; Bone Marrow; Bone Marrow Cells; Cytarabine; Deoxycytidine; DNA; Humans; Leukemia; Neoplastic Stem Cells; Phosphates; Stem Cells | 1987 |
In vitro inhibition of ocular cell proliferation with ara-C: blockage of the antiproliferative effect with 2'-deoxycytidine.
Topics: Cell Division; Cells, Cultured; Cytarabine; Deoxycytidine; Fibroblasts; Humans; Pigment Epithelium of Eye; Sclera | 1986 |
Role of thymidylate synthetase in the cytostatic activity of pyrimidine nucleoside analogues.
Topics: Animals; Antineoplastic Agents; Arabinofuranosyluracil; Cytarabine; Deoxycytidine; Deoxyuridine; Leukemia L1210; Mice; Pyrimidine Nucleosides; Thymidylate Synthase | 1985 |
[Antiviral drugs].
Topics: Acyclovir; Amantadine; Antiviral Agents; Biguanides; Bromodeoxycytidine; Cytarabine; Deoxycytidine; Humans; Idoxuridine; Methisazone; Morpholines; Trifluridine; Vidarabine | 1985 |
Kinetics and substrate specificity of human and canine cytidine deaminase.
Topics: Animals; Arabinofuranosyluracil; Cytarabine; Cytidine; Cytidine Deaminase; Deoxycytidine; Dogs; Humans; Kinetics; Liver; Nucleoside Deaminases; Substrate Specificity | 1986 |
Incorporation of 5-substituted pyrimidine nucleoside analogues into DNA of a thymidylate synthetase-deficient murine FM3A carcinoma cell line.
Topics: Animals; Cell Line; Cytarabine; Deoxycytidine; DNA, Neoplasm; Mammary Neoplasms, Experimental; Methyltransferases; Mice; Pyrimidine Nucleosides; Stimulation, Chemical; Thymidylate Synthase | 1985 |
Effects of hydroxyurea and thymidine derivatives on the uptake and metabolism of deoxycytidine and arabinofuranosylcytosine in log phase and contact-inhibited human diploid fibroblasts.
Topics: Arabinofuranosylcytosine Triphosphate; Cells, Cultured; Cytarabine; Deamination; Deoxycytidine; Deoxyuracil Nucleotides; Fibroblasts; Humans; Hydroxyurea; Thymidine; Thymine Nucleotides; Tritium | 1985 |
The purification and properties of cytidine deaminase from Escherichia coli.
Topics: Aminohydrolases; Chromatography; Cytarabine; Cytidine; Deamination; Deoxycytidine; Deoxyribonucleosides; Edetic Acid; Electrophoresis; Escherichia coli; Hydrogen-Ion Concentration; Metals; Molecular Weight; Pyrimidine Nucleosides; Ribonucleosides; Sulfhydryl Reagents; Urea | 1973 |
Effect of arabinosyl-cytosine on the G1-arrested cells which were subsequently induced to divide by medium change.
Topics: Animals; Cell Line; Cells, Cultured; Culture Media; Cytarabine; Deoxycytidine; DNA; Ethidium; Floxuridine; Kidney; Mice; Mice, Inbred Strains; Mitosis; Thymidine; Time Factors; Tritium | 1974 |
Studies on 1-beta-D-arabinofuranosyl-cytosine-resistant mutants of Chinese-hamster fibroblasts. A mitochondrial deoxycytidine kinase devoid of activity on arabino-cytosine.
Topics: Animals; Cell Line; Cell Nucleus; Centrifugation, Density Gradient; Chromatography, DEAE-Cellulose; Cricetinae; Cytarabine; Deoxycytidine; DNA; DNA, Circular; DNA, Mitochondrial; Drug Resistance; Drug Stability; Fibroblasts; Lung; Mitochondria; Phosphotransferases; Temperature; Tritium | 1973 |
The repair of methyl methanesulphonate-induced lesions in the DNA of a murine lymphoma cell.
Topics: Animals; Cell Line; Centrifugation, Density Gradient; Cytarabine; Deoxycytidine; DNA Repair; DNA Replication; DNA, Single-Stranded; Hydroxyurea; Lymphocytes; Lymphoma; Mesylates; Mice; Mice, Inbred Strains; Radiation Effects; Spectrophotometry, Ultraviolet; Tritium | 1973 |
Mechanisms of resistance of human acute leukaemia cells to cytosine arabinoside.
Topics: Adult; Aminohydrolases; Bone Marrow; Bone Marrow Cells; Cytarabine; Deoxycytidine; Deoxyribonucleosides; Drug Resistance; Humans; Kinetics; Leukemia, Myeloid, Acute; Phosphotransferases; Tritium | 1974 |
Programming of events in Epstein-Barr virus-activated cells induced by 5-iododeoxyuridine.
Topics: Antigens, Viral; Autoradiography; Burkitt Lymphoma; Cell Line; Cells, Cultured; Cytarabine; Deoxycytidine; DNA Replication; DNA, Neoplasm; DNA, Viral; Fluorescent Antibody Technique; Herpesvirus 4, Human; Humans; Hydroxyurea; Idoxuridine; Mitosis; Thymidine; Time Factors; Tritium; Viral Proteins; Virus Replication | 1974 |
Isolation of temperature-sensitive mutants from murine leukemic cells (L5178Y).
Topics: Agar; Animals; Cell Line; Cell Separation; Cell Survival; Cytarabine; Deoxycytidine; DNA, Neoplasm; Leucine; Leukemia, Lymphoid; Mesylates; Mice; Mutagens; Mutation; Neoplasm Proteins; RNA, Neoplasm; Temperature; Tritium; Uridine | 1974 |
Induction of both thymidine and deoxycytidine kinase activity by herpes viruses.
Topics: Animals; Bromodeoxyuridine; Cell Line; Cell-Free System; Cricetinae; Cytarabine; Deoxycytidine; Drug Resistance, Microbial; Enzyme Induction; Herpesviridae; Herpesvirus 1, Suid; Horses; Kidney; Mutation; Phosphotransferases; Simplexvirus; Thymidine; Thymidine Kinase; Tritium; Vaccinia virus; Viral Plaque Assay | 1974 |
Alterations leading to increased ribonucleotide reductase in cells selected for resistance to deoxynucleosides.
Topics: Animals; Autoradiography; Cell Line; Cell-Free System; Cells, Cultured; Chromatography, Ion Exchange; Clone Cells; Cytarabine; Deoxyadenosines; Deoxycytidine; Deoxyribonucleosides; Deoxyribonucleotides; DNA; Drug Resistance; Fibroblasts; Guanosine; Mice; Phosphotransferases; Ribonucleotide Reductases; Thymidine; Thymidine Kinase; Tritium | 1974 |
Distribution of kinase and deaminase of 1-beta-D-arabinofuranosylcytosine in tissues of man and mouse.
Topics: Aminohydrolases; Animals; Bone Marrow; Bone Marrow Cells; Cytarabine; Deoxycytidine; Humans; Kidney; Leukemia, Lymphoid; Leukemia, Myeloid; Leukemia, Myeloid, Acute; Leukocytes; Liver; Mice; Phosphotransferases; Spleen; Uridine | 1973 |
Specific increase in pyrimidine deoxynucleoside transport at the time of deoxyribonucleic acid synthesis in 3T3 mouse cells.
Topics: Animals; Biological Transport; Cell Line; Culture Media; Cycloheximide; Cytarabine; Dactinomycin; Deoxyadenosines; Deoxycytidine; Deoxyribonucleosides; DNA; Electrophoresis, Paper; Fibroblasts; Guanosine; Hydroxyurea; Kinetics; Mice; Mitomycins; Mutation; Phosphates; Phosphorus Isotopes; Thymidine; Thymidine Kinase; Time Factors; Tritium | 1973 |
Studies on the mode of action of 2,2'-anhydro-1- -D-arabinofuranosylcytosine.
Topics: Adenosine Triphosphate; Animals; Antineoplastic Agents; Carbon Isotopes; Carcinoma, Ehrlich Tumor; Cell-Free System; Chromatography, Paper; Cytarabine; Deamination; Deoxycytidine; Drug Resistance; Electrophoresis, Paper; Escherichia coli; Female; Hydrogen-Ion Concentration; Hydrolysis; Leukemia L1210; Mice; Mice, Inbred Strains; Oxidative Phosphorylation | 1973 |
A microbiological assay for cyclocytidine--disposition studies in mice.
Topics: Animals; Biological Assay; Cytarabine; Cytidine; Deoxycytidine; Enterococcus faecalis; Female; Mice; Nucleosides; Uridine | 1973 |
Cycling characteristics of endogenous spleen colony-forming cells as measured with cytosine arabinoside and methotrexate.
Topics: Animals; Cell Survival; Cesium Isotopes; Cytarabine; Deoxycytidine; Erythropoiesis; Female; Hematopoiesis; Iron Radioisotopes; Male; Methotrexate; Mice; Radioisotopes; Spleen | 1973 |
Intra-arterial cancer chemotherapy with combined anticancer agents.
Topics: Adult; Antineoplastic Agents; Cyclophosphamide; Cytarabine; Deoxycytidine; Drug Therapy, Combination; Fluorouracil; Humans; Injections, Intra-Arterial; Leukopenia; Liver Neoplasms; Methotrexate; Middle Aged; Mitomycins; Neoplasms, Connective Tissue; Pyridoxal Phosphate; Stomach Neoplasms; Vinblastine; Vincristine | 1973 |
Metabolic competition studies of 2'-fluoro-5-iodo-1-beta-d-arabinofuranosylcytosine in vero cells and herpes simplex type 1-infected vero cells.
Topics: Animals; Antiviral Agents; Cell Line; Cell Transformation, Viral; Chlorocebus aethiops; Cytarabine; Deoxycytidine; DNA Replication; Idoxuridine; Kidney; Kinetics; Simplexvirus | 1984 |
Cellular differentiation, cytidine analogs and DNA methylation.
Topics: Adipose Tissue; Animals; Azacitidine; Cell Differentiation; Cells, Cultured; Cytarabine; Cytidine; Decitabine; Deoxycytidine; DNA; DNA (Cytosine-5-)-Methyltransferases; Methylation; Methyltransferases; Mice; Muscles; Structure-Activity Relationship | 1980 |
2'-fluoro-5-iodo-aracytosine, a potent and selective anti-herpesvirus agent.
Topics: Antiviral Agents; Cytarabine; Deoxycytidine; Herpesvirus 3, Human; Microbial Sensitivity Tests; Simplexvirus; Thymidine; Thymidine Kinase | 1980 |
Tetrahydrouridine specifically facilitates deoxycytidine incorporation into herpes simplex virus DNA.
Topics: Cytarabine; Deoxycytidine; DNA, Viral; HeLa Cells; Simplexvirus; Tetrahydrouridine; Uridine | 1981 |
Role of deoxycytidine kinase in the inhibitory activity of 5-substituted 2'-deoxycytidines and cytosine arabinosides on tumor cell growth.
Topics: Animals; Antimetabolites, Antineoplastic; Bromodeoxyuridine; Cell Division; Cytarabine; Deoxycytidine; Deoxycytidine Kinase; DNA, Neoplasm; Leukemia L1210; Mice; Phosphotransferases; Thymidine Kinase | 1983 |
Effects of conditioned medium on nucleoside uptake, cell cycle progression and apparent DNA repair.
Topics: Animals; Arvicolinae; Cell Cycle; Cell Line; Cells, Cultured; Cricetinae; Culture Media; Cytarabine; Deoxycytidine; DNA Repair; Fibroblasts; Humans; Mice; Nucleosides; Thymidine; Time Factors | 1983 |
High-performance liquid chromatographic assay for cytosine arabinoside, uracil arabinoside and some related nucleosides.
Topics: Arabinofuranosyluracil; Child; Chromatography, High Pressure Liquid; Cytarabine; Cytidine; Deoxycytidine; Humans; Infusions, Parenteral; Kinetics; Leukemia, Myeloid, Acute; Uridine | 1983 |
Ribo- and deoxyribonucleoside effect on 3'-amino-2',3'-dideoxycytidine-induced cytotoxicity in cultured L1210 cells.
Topics: Animals; Antineoplastic Agents; Cell Survival; Cells, Cultured; Cytarabine; Deamination; Deoxycytidine; Deoxyribonucleosides; DNA, Neoplasm; Leukemia L1210; Ribonucleosides; Zalcitabine | 1983 |
Modulation of metabolism of cytosine arabinoside in L cells by antibody and complement.
Topics: Animals; Antibodies; Cell Line; Complement System Proteins; Cytarabine; Deoxycytidine; Deoxycytidine Kinase; L Cells; Mice; Nucleosides; Thymidine | 1983 |
Cytosine arabinoside transport by human leukaemic cells.
Topics: Acute Disease; Adolescent; Adult; Aged; Biological Transport; Cell Membrane; Child; Child, Preschool; Cytarabine; Deoxycytidine; Humans; Infant; Kinetics; Leukemia; Leukocytes; Middle Aged; Phloretin; Thioinosine | 1983 |
Thymidine as a kinetic and biochemical modulator of 1-beta-D-arabinofuranosylcytosine in human acute nonlymphocytic leukemia.
Topics: Acute Disease; Adult; Cytarabine; Deoxycytidine; Female; Humans; Interphase; Kinetics; Leukemia; Male; Middle Aged; Phosphorylation; Thymidine | 1984 |
Labelling of the thymidine and deoxycytidine bases of DNA by [2-14C]deoxycytidine in cultured L1210 cells.
Topics: 3-Deazauridine; Animals; Carbon Radioisotopes; Cytarabine; Cytidine; Deoxycytidine; DNA; Leukemia L1210; Mice; Tetrahydrouridine; Thymidine | 1983 |
Inhibition by deoxycytidine, cytidine, and beta-cytosine arabinoside of the induction of alkaline phosphatase activity in HeLa cells.
Topics: Alkaline Phosphatase; Cytarabine; Cytidine; Deoxycytidine; DNA; Enzyme Induction; HeLa Cells; Hot Temperature; Humans; Idoxuridine; Kinetics | 1980 |
Enzymatic studies on possible improvement of cytosine arabinoside treatment.
Topics: Adult; Cell Extracts; Cytarabine; Cytidine Deaminase; Deamination; Deoxycytidine; Deoxycytidine Kinase; Female; Humans; Leukemia, Myeloid; Leukocytes; Male; Middle Aged; Phosphorylation | 1981 |
Effects of arabinosyl cytosine and 5-azacytidine on the intestinal absorption of nutrients.
Topics: Amino Acids; Animals; Cytarabine; Cytidine; Deoxycytidine; Electrolytes; Glucose; Intestinal Absorption; Male; Mice; Mice, Inbred Strains | 1982 |
Biochemical effects of 2'-fluoro-5-methyl-1-beta-D-arabinofuranosyluracil and 2'-fluoro-5-iodo-1-beta-D-arabinofuranosylcytosine in mouse leukemic cells sensitive and resistant to 1-beta-D-arabinofuranosylcytosine.
Topics: Animals; Arabinofuranosyluracil; Cell Survival; Cytarabine; Deoxycytidine; DNA Replication; Kinetics; Leukemia L1210; Leukemia, Experimental; Mice; Thymidine; Uridine | 1982 |
[Features of hematopoiesis in mice protected from the lethal effect of cytosar by deoxycytidine].
Topics: Animals; Bone Marrow Diseases; Colony-Forming Units Assay; Cytarabine; Deoxycytidine; Female; Hematologic Diseases; Hematopoietic System; Mice; Mice, Inbred C57BL; Splenic Diseases; Thymus Gland | 1981 |
Effect of thymidine on the toxicity, antitumor activity, and metabolism of 1-beta-D-arabinofuranosylcytosine in rats bearing a chemically induced colon carcinoma.
Topics: Animals; Arabinofuranosylcytosine Triphosphate; Biotransformation; Colonic Neoplasms; Cytarabine; Deoxycytidine; Drug Interactions; Drug Therapy, Combination; Female; Neoplasms, Experimental; Rats; Thymidine; Tissue Distribution | 1980 |
Enhancement of 1-beta-D-arabinofuranosylcytosine accumulation within L1210 cells and increased cytotoxicity following thymidine exposure.
Topics: Animals; Arabinofuranosylcytosine Triphosphate; Cytarabine; Deoxycytidine; Deoxyribonucleotides; DNA, Neoplasm; Leukemia L1210; Mice; RNA, Neoplasm; Thymidine; Time Factors | 1980 |
[Effect of deoxycytidine on the efficacy of cytosine arabinoside in BALB/C mice with Rauscher erythroblastic leukemia].
Topics: Animals; Cytarabine; Deoxycytidine; Drug Combinations; Female; Leukemia, Experimental; Mice; Mice, Inbred BALB C; Organ Size; Rauscher Virus; Spleen | 1980 |
Consequences of 2',2'-difluorodeoxycytidine (gemcitabine) on replicative DNA synthesis in intact HL-60 cells.
Topics: Antimetabolites, Antineoplastic; Cytarabine; Cytidine Triphosphate; Deoxycytidine; DNA Replication; DNA, Neoplasm; Dose-Response Relationship, Drug; Gemcitabine; Guanosine Triphosphate; Half-Life; HL-60 Cells; Humans; Nucleosides; Peptide Chain Elongation, Translational; Thymine | 1995 |
Evaluation of the cytotoxic activity of gemcitabine in primary cultures of tumor cells from patients with hematologic or solid tumors.
Topics: Antibiotics, Antineoplastic; Antimetabolites, Antineoplastic; Antineoplastic Agents; Breast Neoplasms; Cisplatin; Cladribine; Colorectal Neoplasms; Cytarabine; Deoxycytidine; Dose-Response Relationship, Drug; Doxorubicin; Etoposide; Female; Gemcitabine; Humans; In Vitro Techniques; Leukemia; Lung Neoplasms; Lymphoma; Ribonucleotide Reductases; Tumor Cells, Cultured; Urogenital Neoplasms | 1995 |
Identification of cytidine deaminase as inhibitor of granulocyte-macrophage colony formation.
Topics: Animals; Azacitidine; Bone Marrow Cells; Cell Division; Cytarabine; Cytidine Deaminase; Deoxycytidine; Deoxyuridine; DNA; Female; Granulocytes; Hematopoietic Stem Cells; Macrophages; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Thymidine | 1994 |
Cytosine arabinoside induces apoptosis in cerebellar neurons in culture.
Topics: Animals; Apoptosis; Cell Nucleus; Cells, Cultured; Cerebellum; Cytarabine; Deoxycytidine; DNA; Neurons; Nucleosomes; Protein Biosynthesis; Proteins; Rats; RNA | 1995 |
Cell viability and laminin-induced neurite outgrowth in cultures of embryonic chick neural tube cells: effects of cytosine-B-D-arabinofuranoside.
Topics: Animals; Biological Assay; Cell Survival; Cells, Cultured; Central Nervous System; Chick Embryo; Cytarabine; Cytosine; Deoxycytidine; Laminin; Neurites; Neurons | 1995 |
Role of deoxycytidine kinase in an in vitro model for AraC- and DAC-resistance: substrate-enzyme interactions with deoxycytidine, 1-beta-D-arabinofuranosylcytosine and 5-aza-2'-deoxycytidine.
Topics: Acute Disease; Animals; Antineoplastic Agents; Azacitidine; Binding, Competitive; Cytarabine; Decitabine; Deoxycytidine; Deoxycytidine Kinase; Drug Resistance; In Vitro Techniques; Kinetics; Leukemia, Myeloid; Rats; Rats, Inbred BN; Tumor Cells, Cultured | 1993 |
Enhancement of filtration surgery with cytosine arabinoside and reversal of toxicity with 2'-deoxycytidine.
Topics: Animals; Chemotherapy, Adjuvant; Cornea; Corneal Diseases; Cytarabine; Deoxycytidine; Epithelium; Filtering Surgery; Glaucoma; Injections; Intraocular Pressure; Rabbits; Scleroplasty | 1994 |
[Synergistic cytotoxic effects of chemotherapy in colon tumor cells by simultaneous inhibition of de novo and salvage energy metabolism pathways].
Topics: Allopurinol; Antimetabolites, Antineoplastic; Benzamidines; Cell Line; Cell Survival; Colonic Neoplasms; Cytarabine; Deoxycytidine; Dose-Response Relationship, Drug; Drug Synergism; Gemcitabine; Humans; Hypoxanthine; Hypoxanthines; Ribavirin; Ribonucleotide Reductases; Tumor Cells, Cultured; Tumor Stem Cell Assay | 1994 |
Molecular effects of 2',2'-difluorodeoxycytidine (Gemcitabine) on DNA replication in intact HL-60 cells.
Topics: Antimetabolites, Antineoplastic; Cell Death; Cytarabine; Deoxycytidine; Deoxycytosine Nucleotides; Deoxyguanine Nucleotides; DNA Replication; DNA, Neoplasm; Dose-Response Relationship, Drug; Drug Stability; Gemcitabine; Humans; Hydrogen-Ion Concentration; Tumor Cells, Cultured | 1994 |
N4-(dialkylamino)methylene derivatives of 2'-deoxycytidine and arabinocytidine: physicochemical studies for potential prodrug applications.
Topics: Animals; Chemical Phenomena; Chemistry, Physical; Cytarabine; Deoxycytidine; Drug Stability; Half-Life; Hydrolysis; Kinetics; Leukemia L1210; Lipids; Mice; Prodrugs; Solubility | 1994 |
Regulation of thymidine kinase and thymidylate synthase in intact human lymphoblast CCRF-CEM cells.
Topics: Aphidicolin; Carbon Radioisotopes; Cell Cycle; Cytarabine; Deoxycytidine; Deoxyuridine; DNA Replication; DNA, Neoplasm; Hydroxyurea; Kinetics; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Thymidine Kinase; Thymidylate Synthase; Time Factors; Tritium; Tumor Cells, Cultured | 1993 |
Nucleosides and nucleotides. 123. Synthesis of 1-(2-deoxy-2-isocyano-beta-D-arabinofuranosyl)cytosine and related nucleosides as potential antitumor agents.
Topics: Animals; Antineoplastic Agents; Cytarabine; Deoxycytidine; Drug Stability; Humans; Isocyanates; Leukemia L1210; Lung Neoplasms; Mice; Molecular Structure; Mouth Neoplasms; Stomach Neoplasms; Thymine; Tumor Cells, Cultured; Uracil | 1993 |
Deoxyguanosine-resistant leukemia L1210 cells. Loss of specific deoxyribonucleoside kinase activity.
Topics: Animals; Antineoplastic Agents; Cell Division; Cytarabine; Deoxycytidine; Deoxyguanosine; Drug Resistance; Kinetics; Leukemia L1210; Mice; Nucleosides; Phosphotransferases; Phosphotransferases (Alcohol Group Acceptor); Tumor Cells, Cultured | 1993 |
Comparison of the induction of apoptosis in human leukemic cell lines by 2',2'-difluorodeoxycytidine (gemcitabine) and cytosine arabinoside.
Topics: Alkaloids; Antimetabolites, Antineoplastic; Apoptosis; Blotting, Northern; Cytarabine; Deoxycytidine; DNA Damage; DNA, Neoplasm; Drug Synergism; Enzyme Inhibitors; Gemcitabine; Gene Expression; Genes, fos; Genes, jun; HL-60 Cells; Humans; Leukemia, T-Cell; Protein Kinase C; Staurosporine; Tumor Cells, Cultured | 1995 |
In vitro sensitivity of macropodid herpesvirus 2 to selected anti-herpetic compounds.
Topics: Acyclovir; Animals; Antiviral Agents; Arabinonucleosides; Bromodeoxycytidine; Bromodeoxyuridine; Cell Line; Cytarabine; Deoxycytidine; Herpesviridae; Herpesviridae Infections; Idoxuridine; Macropodidae; Microbial Sensitivity Tests; Neutralization Tests; Thymidine; Trifluridine; Vidarabine | 1996 |
Effects of fludarabine and gemcitabine on human acute myeloid leukemia cell line HL 60: direct comparison of cytotoxicity and cellular Ara-C uptake enhancement.
Topics: Antimetabolites, Antineoplastic; Antineoplastic Agents; Apoptosis; Cell Division; Cell Survival; Cytarabine; Deoxycytidine; Drug Interactions; Gemcitabine; HL-60 Cells; Humans; Thymidine; Vidarabine | 1996 |
Forced expression of cytidine deaminase confers resistance to cytosine arabinoside and gemcitabine.
Topics: 3T3 Cells; Animals; Antimetabolites, Antineoplastic; Cytarabine; Cytidine Deaminase; Deoxycytidine; Drug Resistance; Gemcitabine; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Gene Transfer Techniques; Humans; Mice | 1996 |
Enhanced sensitivity to 1-beta-D-arabinofuranosylcytosine and topoisomerase II inhibitors in tumor cell lines harboring activated ras oncogenes.
Topics: Antibiotics, Antineoplastic; Antimetabolites, Antineoplastic; Carcinoma, Non-Small-Cell Lung; Colonic Neoplasms; Cytarabine; Daunorubicin; Deoxycytidine; DNA Mutational Analysis; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Gemcitabine; Gene Expression Regulation, Neoplastic; Genes, ras; Humans; Lung Neoplasms; Software; Topoisomerase II Inhibitors; Tumor Cells, Cultured | 1996 |
Cell kill kinetics of an antineoplastic nucleoside, 1-(2-deoxy-2-methylene-beta-D-erythro-pentofuranosyl)cytosine.
Topics: Antineoplastic Agents; Cell Cycle; Cell Death; Cytarabine; Deoxycytidine; Deoxycytosine Nucleotides; Humans; Kinetics; Phosphorylation; S Phase; Tumor Cells, Cultured | 1996 |
Comparison of the antitumor activity of gemcitabine and ara-C in a panel of human breast, colon, lung and pancreatic xenograft models.
Topics: Animals; Antimetabolites, Antineoplastic; Breast Neoplasms; Colonic Neoplasms; Cytarabine; Deoxycytidine; Gemcitabine; Humans; Lung Neoplasms; Mice; Mice, Nude; Models, Biological; Molecular Structure; Pancreatic Neoplasms; Transplantation, Heterologous; Treatment Outcome | 1996 |
Seeking the nucleoside transporter.
Topics: Animals; Antimetabolites, Antineoplastic; Carrier Proteins; Cell Membrane; Cladribine; Cloning, Molecular; Cytarabine; Deoxycytidine; Erythrocytes; Gemcitabine; Glucose Transporter Type 1; Humans; Leukemia; Lymphoma; Membrane Proteins; Monosaccharide Transport Proteins; Nucleosides; Oocytes; Recombinant Proteins; Uridine; Vidarabine; Xenopus | 1997 |
Cytosine arabinoside is neurotoxic to chick embryo spinal cord motoneurons in culture.
Topics: Animals; Antimetabolites, Antineoplastic; Cells, Cultured; Chick Embryo; Cytarabine; Deoxycytidine; Dose-Response Relationship, Drug; Motor Neurons; Neurotoxins; Osmolar Concentration; Spinal Cord | 1997 |
Differential incorporation of ara-C, gemcitabine, and fludarabine into replicating and repairing DNA in proliferating human leukemia cells.
Topics: Antineoplastic Agents; Binding Sites; Cytarabine; Deoxycytidine; DNA Repair; DNA Replication; DNA, Neoplasm; Gemcitabine; Humans; Leukemia; Tumor Cells, Cultured; Vidarabine | 1997 |
Deoxycytidine in human plasma: potential for protecting leukemic cells during chemotherapy.
Topics: Adult; Cladribine; Cytarabine; Deoxycytidine; Deoxycytosine Nucleotides; Humans; Male; Middle Aged; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Vidarabine | 1997 |
Alterations in the properties of mouse leukemia L1210 cell lines selected by different methods for resistance to deoxyguanosine.
Topics: Animals; Cell Division; Cladribine; Cytarabine; Deoxycytidine; Deoxycytidine Kinase; Deoxyguanosine; Drug Resistance, Neoplasm; Kinetics; Leukemia L1210; Mice; Phosphotransferases (Alcohol Group Acceptor); Tumor Cells, Cultured | 1997 |
Regulation of deoxycytidine kinase by deoxycytidine and deoxycytidine 5' triphosphate in whole leukemia and tumor cells.
Topics: Animals; Arabinofuranosylcytosine Triphosphate; CHO Cells; Cricetinae; Cytarabine; Deoxycytidine; Deoxycytidine Kinase; Deoxycytosine Nucleotides; HL-60 Cells; Homeostasis; Humans; Leukemia; Ribonucleotide Reductases; Tumor Cells, Cultured | 1998 |
Protection of leukemic cells by deoxycytidine: in vitro measures of protection against cytosine arabinoside.
Topics: Cell Survival; Cytarabine; Deoxycytidine; DNA; Dose-Response Relationship, Drug; Formazans; Humans; Intracellular Fluid; Leukemia-Lymphoma, Adult T-Cell; Tetrazolium Salts; Tumor Cells, Cultured | 1998 |
Drug resistance to 5-aza-2'-deoxycytidine, 2',2'-difluorodeoxycytidine, and cytosine arabinoside conferred by retroviral-mediated transfer of human cytidine deaminase cDNA into murine cells.
Topics: 3T3 Cells; Animals; Antimetabolites; Antimetabolites, Antineoplastic; Azacitidine; Colony-Forming Units Assay; Cytarabine; Cytidine Deaminase; Decitabine; Deoxycytidine; DNA, Complementary; Drug Resistance; Enzyme Inhibitors; Fibroblasts; Gemcitabine; Gene Transfer Techniques; Genetic Vectors; Humans; Mice; Phenotype; Retroviridae; Tetrahydrouridine | 1998 |
Lack of cross-resistance with gemcitabine and cytarabine in cladribine-resistant HL60 cells with elevated 5'-nucleotidase activity.
Topics: 5'-Nucleotidase; Adenosine Triphosphate; Antimetabolites, Antineoplastic; Antineoplastic Agents; Blotting, Northern; Cladribine; Cytarabine; Cytoplasm; Deoxycytidine; Deoxycytidine Kinase; Drug Resistance, Neoplasm; Gemcitabine; HL-60 Cells; Humans; RNA, Messenger | 1998 |
Decreased resistance to gemcitabine (2',2'-difluorodeoxycitidine) of cytosine arabinoside-resistant myeloblastic murine and rat leukemia cell lines: role of altered activity and substrate specificity of deoxycytidine kinase.
Topics: Animals; Antimetabolites, Antineoplastic; Cell Division; Cytarabine; Cytidine Deaminase; Deoxycytidine; Deoxycytidine Kinase; DNA; Drug Resistance; Gemcitabine; Leukemia L1210; Mice; Nucleoside Deaminases; Polyphosphates; Rats; Rats, Inbred BN; Substrate Specificity; Thymidine Kinase; Tumor Cells, Cultured | 1999 |
[Non-clinical studies of gemcitabine--the mode of action and antitumor activities].
Topics: Animals; Antimetabolites, Antineoplastic; Cytarabine; Deoxycytidine; Gemcitabine; Humans; Mice; Mice, Nude; Tumor Cells, Cultured | 1999 |
Combination chemotherapy for choroidal melanoma: ex vivo sensitivity to treosulfan with gemcitabine or cytosine arabinoside.
Topics: Adenosine Triphosphate; Antineoplastic Combined Chemotherapy Protocols; Busulfan; Choroid Neoplasms; Cytarabine; Deoxycytidine; Gemcitabine; Humans; Melanoma; Paclitaxel; Tumor Stem Cell Assay | 1999 |
Antitumor activity and novel DNA-self-strand-breaking mechanism of CNDAC (1-(2-C-cyano-2-deoxy-beta-D-arabino-pentofuranosyl) cytosine) and its N4-palmitoyl derivative (CS-682).
Topics: Administration, Oral; Animals; Antimetabolites, Antineoplastic; Arabinonucleosides; Biotransformation; Breast Neoplasms; Cisplatin; Cytarabine; Cytosine; Deoxycytidine; Deoxycytidine Kinase; DNA Damage; DNA, Neoplasm; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Female; Fluorouracil; Humans; KB Cells; Leukemia P388; Mice; Mice, Inbred BALB C; Mice, Inbred DBA; Mice, Nude; Mitomycin; Molecular Structure; Neoplasm Proteins; Neoplasm Transplantation; Neoplasms, Experimental; Rats; Rats, Nude; Specific Pathogen-Free Organisms; Stomach Neoplasms; Tumor Cells, Cultured; Vincristine | 1999 |
Inhibition of protein kinase C activator-mediated induction of p21CIP1 and p27KIP1 by deoxycytidine analogs in human leukemia cells: relationship to apoptosis and differentiation.
Topics: Antimetabolites, Antineoplastic; Apoptosis; Bryostatins; Cell Cycle Proteins; Cell Differentiation; Cyclin-Dependent Kinase Inhibitor p21; Cyclin-Dependent Kinase Inhibitor p27; Cyclins; Cytarabine; Deoxycytidine; Drug Interactions; Enzyme Activation; Gemcitabine; Humans; Lactones; Leukemia; Macrolides; Microtubule-Associated Proteins; Mitogens; Protein Kinase C; Tetradecanoylphorbol Acetate; Tumor Suppressor Proteins; U937 Cells | 1999 |
Common resistance mechanisms to deoxynucleoside analogues in variants of the human erythroleukaemic line K562.
Topics: Antineoplastic Agents; Cladribine; Cytarabine; Deoxycytidine; Deoxycytidine Kinase; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Gemcitabine; Humans; K562 Cells; Leukemia, Erythroblastic, Acute; Phenotype; Vidarabine | 1999 |
Phosphorylation of deoxycytidine analog monophosphates by UMP-CMP kinase: molecular characterization of the human enzyme.
Topics: Amino Acid Sequence; Antimetabolites, Antineoplastic; Base Sequence; Blotting, Northern; Chromosome Mapping; Chromosomes, Human, Pair 1; Cloning, Molecular; Cytarabine; Deoxycytidine; DNA, Complementary; Gemcitabine; Humans; Molecular Sequence Data; Nucleoside-Phosphate Kinase; Phosphorylation; Recombinant Proteins; Sequence Homology, Amino Acid; Subcellular Fractions | 1999 |
Comparison of 1-(2-deoxy-2-fluoro-4-thio-beta-D-arabinofuranosyl)cytosine with gemcitabine in its antitumor activity.
Topics: Animals; Antimetabolites, Antineoplastic; Antineoplastic Agents; Colonic Neoplasms; Cytarabine; Deoxycytidine; Drug Screening Assays, Antitumor; Female; Gemcitabine; Humans; Mice; Mice, Inbred BALB C; Mice, Nude; Neoplasm Transplantation; Stomach Neoplasms; Transplantation, Heterologous; Tumor Cells, Cultured | 1999 |
Effects of gemcitabine and araC on in vitro DNA synthesis mediated by the human breast cell DNA synthesome.
Topics: Antigens, Polyomavirus Transforming; Antimetabolites, Antineoplastic; Arabinofuranosylcytosine Triphosphate; Breast Neoplasms; Cloning, Molecular; Cytarabine; Deoxycytidine; DNA Polymerase I; DNA Polymerase III; DNA, Neoplasm; Gemcitabine; Humans; Replicon; Tumor Cells, Cultured | 2000 |
Successful modulation of high-dose cytosine arabinoside metabolism in acute myeloid leukaemia by haematopoietic growth factors: no effect of ribonucleotide reductase inhibitors fludarabine and gemcitabine.
Topics: Arabinofuranosylcytosine Triphosphate; Cytarabine; Deoxycytidine; Deoxycytidine Kinase; Drug Administration Schedule; Enzyme Inhibitors; Gemcitabine; Granulocyte Colony-Stimulating Factor; Granulocyte-Macrophage Colony-Stimulating Factor; Hematopoietic Cell Growth Factors; Humans; Immunosuppressive Agents; Leukemia, Myeloid; Ribonucleotide Reductases; Vidarabine | 2000 |
The interaction of gemcitabine and cytarabine on murine leukemias L1210 or P388 and on human normal and leukemic cell growth in vitro.
Topics: Animals; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Cell Culture Techniques; Cytarabine; Deoxycytidine; Gemcitabine; Humans; Leukemia, Experimental; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Male; Mice; Mice, Inbred Strains; Stem Cells; Tumor Cells, Cultured | 2000 |
A novel action of human apurinic/apyrimidinic endonuclease: excision of L-configuration deoxyribonucleoside analogs from the 3' termini of DNA.
Topics: Anions; Antineoplastic Agents; Antiviral Agents; Blotting, Western; Carbon-Oxygen Lyases; Cations; Chromatography, Agarose; Chromatography, Ion Exchange; Cytarabine; Cytosine; Deoxycytidine; Deoxycytidine Monophosphate; Deoxyribonuclease IV (Phage T4-Induced); Dioxolanes; DNA; DNA-(Apurinic or Apyrimidinic Site) Lyase; Electrophoresis, Polyacrylamide Gel; Endonucleases; Humans; Oligonucleotides; Recombinant Proteins; Reverse Transcriptase Inhibitors; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Stereoisomerism; Thionucleosides; Tumor Cells, Cultured; Zalcitabine | 2000 |
Retroviral transduction of cancer cell lines with the gene encoding Drosophila melanogaster multisubstrate deoxyribonucleoside kinase.
Topics: Adenocarcinoma; Animals; Antimetabolites, Antineoplastic; Antineoplastic Agents; Antiviral Agents; Arabinonucleosides; Bromodeoxyuridine; Catalysis; Cell Division; Cell Nucleus; Cladribine; Cytarabine; Deoxycytidine; Drosophila melanogaster; Gemcitabine; Humans; Inhibitory Concentration 50; Kinetics; Osteosarcoma; Pancreatic Neoplasms; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor); Promoter Regions, Genetic; Retroviridae; Substrate Specificity; Thymidine; Thymidine Kinase; Transduction, Genetic; Tumor Cells, Cultured | 2000 |
Metabolism of 4'-thio-beta-D-arabinofuranosylcytosine in CEM cells.
Topics: Animals; Antineoplastic Agents; Arabinonucleosides; Biological Transport; Cell Division; Cytarabine; Cytidine Deaminase; Deamination; Deoxycytidine; Deoxycytidine Kinase; Deoxycytosine Nucleotides; DNA; Humans; Male; Mice; Mice, Nude; Thionucleosides; Tumor Cells, Cultured | 2000 |
Evidence against apoptosis as a major mechanism for reproductive cell death following treatment of cell lines with anti-cancer drugs.
Topics: Animals; Antineoplastic Agents; Apoptosis; bcl-2-Associated X Protein; Cell Division; Cell Survival; CHO Cells; Cisplatin; Cricetinae; Cytarabine; Deoxycytidine; Doxorubicin; Etoposide; Gemcitabine; Genes, bcl-2; Humans; In Situ Nick-End Labeling; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Transfection; Tumor Cells, Cultured | 2001 |
Induction of differentiation of acute promyelocytic leukemia cells by a cytidine deaminase-resistant analogue of 1-beta-D-arabinofuranosylcytosine, 1-(2-deoxy-2-methylene-beta-D-erythro-pentofuranosyl)cytidine.
Topics: Antimetabolites, Antineoplastic; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Cell Differentiation; Cell Division; Cytarabine; Cytidine Deaminase; Deoxycytidine; Drug Resistance, Neoplasm; Drug Synergism; Female; Growth Inhibitors; HL-60 Cells; Humans; Leukemia, Promyelocytic, Acute; Male; Middle Aged; Tretinoin; Tumor Cells, Cultured; U937 Cells | 2001 |
2'-C-cyano-2'-deoxy-1-beta-D-arabino-pentofuranosylcytosine: a novel anticancer nucleoside analog that causes both DNA strand breaks and G(2) arrest.
Topics: Antineoplastic Agents; CDC2 Protein Kinase; Chromosome Breakage; Cyclin B; Cyclin B1; Cytarabine; Deoxycytidine; DNA, Neoplasm; G2 Phase; Gemcitabine; Humans; Leukemia, Myeloid, Acute; Lymphocytes; Phosphorylation; RNA; Tumor Cells, Cultured | 2001 |
Collateral sensitivity to gemcitabine (2',2'-difluorodeoxycytidine) and cytosine arabinoside of daunorubicin- and VM-26-resistant variants of human small cell lung cancer cell lines.
Topics: Adenosine Triphosphate; Antimetabolites, Antineoplastic; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Arabinofuranosylcytosine Triphosphate; Carcinoma, Small Cell; Cell Survival; Cytarabine; Cytidine Deaminase; Daunorubicin; Deoxycytidine; Deoxycytidine Kinase; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Drug Synergism; Gemcitabine; Guanosine Triphosphate; Humans; Lung Neoplasms; Nucleoside Deaminases; Teniposide; Thymidine Kinase; Tumor Cells, Cultured; Uridine Triphosphate | 2001 |
The antitumor mechanism of 1-(2-deoxy-2-fluoro-4-thio-beta-D-arabinofuranosyl)-cytosine: effects of its triphosphate on mammalian DNA polymerases.
Topics: Antineoplastic Agents; Carcinoma, Squamous Cell; Cell Death; Cell Division; Cytarabine; Deoxycytidine; DNA Polymerase I; Drug Interactions; Drug Synergism; Enzyme Inhibitors; Gemcitabine; Kinetics; Mouth Neoplasms; Nucleic Acid Synthesis Inhibitors; Tumor Cells, Cultured | 2001 |
An efficient method for the preparation of 1'alpha-branched-chain sugar pyrimidine ribonucleosides from uridine: the first conversion of a natural nucleoside into 1'-substituted ribonucleosides.
Topics: Cyclization; Cytarabine; Cytidine; Deoxycytidine; Glycosylation; Molecular Structure; Organoselenium Compounds; Pyrimidine Nucleosides; Ribonucleosides; Selenium; Silicon; Stereoisomerism; Structure-Activity Relationship; Uridine; Vinyl Compounds | 2001 |
Deletion mutants of human deoxycytidine kinase mRNA in cells resistant to antitumor cytosine nucleosides.
Topics: Antimetabolites, Antineoplastic; Cytarabine; Deoxycytidine; Deoxycytidine Kinase; Drug Resistance, Neoplasm; Fibrosarcoma; Gene Deletion; Gene Expression; Humans; Inhibitory Concentration 50; Melanoma; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Tumor Cells, Cultured | 2001 |
Mechanisms of uptake and resistance to troxacitabine, a novel deoxycytidine nucleoside analogue, in human leukemic and solid tumor cell lines.
Topics: Amino Acid Sequence; Antineoplastic Agents; Biological Transport; Carrier Proteins; Cytarabine; Cytidine Deaminase; Cytosine; Deoxycytidine; Deoxycytidine Kinase; Dioxolanes; Drug Resistance, Neoplasm; Gemcitabine; Humans; Leukemia; Male; Membrane Proteins; Molecular Sequence Data; Nucleoside Transport Proteins; Phosphorylation; Prostatic Neoplasms; Sequence Homology, Amino Acid; Sodium; Stereoisomerism; Tritium; Tumor Cells, Cultured; Uridine | 2001 |
Bystander effects of nucleoside analogs phosphorylated in the cytosol or mitochondria.
Topics: Animals; CHO Cells; Cricetinae; Cytarabine; Cytosol; Deoxycytidine; Deoxycytidine Kinase; Gemcitabine; Genetic Therapy; Mitochondria; Neoplasms; Nucleosides; Phosphorylation | 2001 |
Selection of drug-resistant transduced cells with cytosine nucleoside analogs using the human cytidine deaminase gene.
Topics: Antimetabolites, Antineoplastic; Azacitidine; Bone Marrow Cells; Colony-Forming Units Assay; Cytarabine; Cytidine Deaminase; Decitabine; Deoxycytidine; DNA Modification Methylases; Drug Evaluation; Drug Resistance; Enzyme Inhibitors; Flow Cytometry; Gene Transfer Techniques; Genetic Vectors; Green Fluorescent Proteins; Humans; Leukemia; Luminescent Proteins; Retroviridae; Transgenes | 2001 |
S-acyl-2-thioethyl (SATE) pronucleotides are potent inhibitors of HIV-1 replication in T-lymphoid cells cross-resistant to deoxycytidine and thymidine analogs.
Topics: Anti-HIV Agents; Antiviral Agents; Cell Division; Cell Line; Cytarabine; Deoxycytidine; Deoxycytidine Kinase; Drug Resistance; HIV Infections; HIV-1; Humans; Microbial Sensitivity Tests; Prodrugs; Reverse Transcriptase Inhibitors; T-Lymphocytes; Thymidine; Thymidine Kinase; Virus Replication | 2002 |
A novel type of metastatically spreading subcutaneous aspergillosis without epidermal lesions following allogeneic stem cell transplantation.
Topics: Adult; Amphotericin B; Antifungal Agents; Antineoplastic Combined Chemotherapy Protocols; Aspergillosis; Bleomycin; Carmustine; Combined Modality Therapy; Cyclophosphamide; Cytarabine; Dacarbazine; Deoxycytidine; Dexamethasone; Doxorubicin; Etoposide; Fatal Outcome; Gemcitabine; Hematopoietic Stem Cell Transplantation; Hodgkin Disease; Humans; Immunocompromised Host; Klebsiella Infections; Klebsiella pneumoniae; Lung Diseases, Fungal; Male; Melphalan; Neoplasm Recurrence, Local; Opportunistic Infections; Pneumonia, Bacterial; Pneumonia, Pneumocystis; Prednisone; Procarbazine; Salvage Therapy; Skin; Transplantation, Homologous; Vinblastine; Vincristine | 2001 |
Enhancement of DNA ligase I level by gemcitabine in human cancer cells.
Topics: Antimetabolites, Antineoplastic; Blotting, Western; Cell Cycle; Cytarabine; Deoxycytidine; DNA Ligase ATP; DNA Ligases; Dose-Response Relationship, Drug; Enzyme Activation; Fluorouracil; Gemcitabine; Humans; Hydroxyurea; Tumor Cells, Cultured | 2002 |
Combination effects of alkylphosphocholines and gemcitabine in malignant and normal hematopoietic cells.
Topics: Antimetabolites, Antineoplastic; Apoptosis; Cell Survival; Cell-Free System; Cytarabine; Deoxycytidine; Dose-Response Relationship, Drug; Drug Synergism; Gemcitabine; Hematopoietic Stem Cells; HL-60 Cells; Humans; K562 Cells; Phosphorylcholine; Reference Values; Tumor Cells, Cultured | 2002 |
Cytotoxic activity of 2',2'-difluorodeoxycytidine, 5-aza-2'-deoxycytidine and cytosine arabinoside in cells transduced with deoxycytidine kinase gene.
Topics: 3T3 Cells; Animals; Azacitidine; Cell Death; Cell Line; Cytarabine; Cytidine Deaminase; Decitabine; Deoxycytidine; Deoxycytidine Kinase; DNA, Complementary; Dose-Response Relationship, Drug; Gemcitabine; Genetic Vectors; Humans; Mice; Phenotype; Phosphorylation; Retroviridae; Thymidine Kinase; Tumor Cells, Cultured | 2002 |
Preclinical combination chemotherapy of nedaplatin with gemcitabine against gemcitabine-refractory human lung cancer.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP-Binding Cassette Transporters; Cytarabine; Deoxycytidine; Gemcitabine; Humans; Lung Neoplasms; Mice; Mice, Inbred BALB C; Mice, Nude; Neoplasm Transplantation; Organoplatinum Compounds; Transplantation, Heterologous; Tumor Cells, Cultured; Vault Ribonucleoprotein Particles | 2002 |
The catalytic DNA topoisomerase II inhibitor ICRF-193 and all-trans retinoic acid cooperatively induce granulocytic differentiation of acute promyelocytic leukemia cells: candidate drugs for chemo-differentiation therapy against acute promyelocytic leukem
Topics: Antineoplastic Agents; Catalysis; Cell Cycle; Cell Differentiation; Cell Division; Cyclin-Dependent Kinase Inhibitor p21; Cyclins; Cytarabine; Daunorubicin; Deoxycytidine; Diketopiperazines; Drug Screening Assays, Antitumor; Drug Synergism; Enzyme Inhibitors; Granulocytes; HL-60 Cells; Humans; Leukemia, Promyelocytic, Acute; Neoplasm Proteins; Neoplastic Stem Cells; Piperazines; Razoxane; Receptors, Retinoic Acid; Retinoic Acid Receptor alpha; RNA, Messenger; RNA, Neoplasm; Topoisomerase II Inhibitors; Tretinoin; Tumor Cells, Cultured; U937 Cells | 2002 |
Phosphorylation of 4'-thio-beta-D-arabinofuranosylcytosine and its analogs by human deoxycytidine kinase.
Topics: Adenosine Triphosphate; Arabinonucleosides; Cell Division; Cell Extracts; Cytarabine; Deoxycytidine; Deoxycytidine Kinase; Humans; Phosphoric Monoester Hydrolases; Phosphorylation; Tumor Cells, Cultured; Uridine Triphosphate | 2003 |
Sensitization of ara-C-resistant lymphoma cells by a pronucleotide analogue.
Topics: Antimetabolites, Antineoplastic; Arabinofuranosylcytosine Triphosphate; Cell Division; Chromatography, High Pressure Liquid; Cytarabine; Deoxycytidine; Deoxycytidine Kinase; Drug Resistance, Neoplasm; Gemcitabine; Humans; Lymphoma, Follicular; Nucleic Acid Synthesis Inhibitors; Prodrugs; Tumor Cells, Cultured | 2003 |
Synthesis and cytotoxic activity of two novel 1-dodecylthio-2-decyloxypropyl-3-phosphatidic acid conjugates with gemcitabine and cytosine arabinoside.
Topics: Antineoplastic Agents; Buffers; Cell Line; Cytarabine; Deoxycytidine; Gemcitabine; Humans; Inhibitory Concentration 50; Phosphatidic Acids; Ribonucleotide Reductases; Solubility | 2003 |
THE REVERSAL OF CYTOSINE ARABINOSIDE ACTIVITY IN VIVO BY DEOXYCYTIDINE.
Topics: Animals; Antineoplastic Agents; Carcinoma, Ehrlich Tumor; Cytarabine; Cytosine; Deoxycytidine; Leukemia; Leukemia, Experimental; Neoplasms; Neoplasms, Experimental; Nucleosides; Pharmacology; Research; Sarcoma 180 | 1964 |
Physical and functional interactions between USF and Sp1 proteins regulate human deoxycytidine kinase promoter activity.
Topics: Animals; Antimetabolites, Antineoplastic; Base Sequence; Blotting, Western; Cell Line; Cell Line, Tumor; Cell Nucleus; Chromatin; Cytarabine; Deoxycytidine; Deoxycytidine Kinase; DNA-Binding Proteins; Drosophila; Gemcitabine; Gene Deletion; Gene Expression Regulation, Enzymologic; Humans; Molecular Sequence Data; Mutagenesis, Site-Directed; Plasmids; Precipitin Tests; Promoter Regions, Genetic; Protein Binding; Protein Structure, Tertiary; Sp1 Transcription Factor; Transcription Factors; Transfection; Upstream Stimulatory Factors | 2003 |
2'-fluoro-2'-deoxycytidine inhibits Borna disease virus replication and spread.
Topics: Animals; Antiviral Agents; Borna Disease; Borna disease virus; Chlorocebus aethiops; Cytarabine; Deoxycytidine; RNA, Viral; Vero Cells; Virus Replication | 2004 |
Polymerization of the triphosphates of AraC, 2',2'-difluorodeoxycytidine (dFdC) and OSI-7836 (T-araC) by human DNA polymerase alpha and DNA primase.
Topics: Arabinonucleosides; Cytarabine; Deoxycytidine; DNA Polymerase I; DNA Primase; Gemcitabine; Humans; Polymers; Polyphosphates | 2004 |
Modulation of cytarabine induced cytotoxicity using novel deoxynucleoside analogs in the HL60 cell line.
Topics: Antimetabolites, Antineoplastic; Antineoplastic Agents; Cell Line, Tumor; Cladribine; Coloring Agents; Cytarabine; Deoxycytidine; DNA; Gemcitabine; HL-60 Cells; Humans; Inhibitory Concentration 50; Nucleosides; Tetrazolium Salts; Thiazoles; Vidarabine | 2004 |
Antiproliferative activity and mechanism of action of fatty acid derivatives of arabinosylcytosine (ara-C) in leukemia and solid tumor cell lines.
Topics: Animals; Antimetabolites, Antineoplastic; Cell Line, Tumor; Cell Proliferation; Cytarabine; Deoxycytidine; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm; Fatty Acids; Gemcitabine; Humans; Inhibitory Concentration 50; Leukemia; Mice; Neoplasms; Rats; Time Factors | 2004 |
Gemcitabine-induced activation of checkpoint signaling pathways that affect tumor cell survival.
Topics: Ataxia Telangiectasia Mutated Proteins; Cell Cycle Proteins; Cell Line, Tumor; Cell Survival; Checkpoint Kinase 1; Checkpoint Kinase 2; Cytarabine; Deoxycytidine; DNA-Binding Proteins; Dose-Response Relationship, Drug; Gemcitabine; Humans; Protein Kinases; Protein Serine-Threonine Kinases; Signal Transduction; Tumor Suppressor Proteins | 2005 |
Resistance to cytarabine and gemcitabine and in vitro selection of transduced cells after retroviral expression of cytidine deaminase in human hematopoietic progenitor cells.
Topics: Cells, Cultured; Cytarabine; Cytidine Deaminase; Deoxycytidine; Dose-Response Relationship, Drug; Drug Resistance, Multiple; Erythroid Precursor Cells; Gemcitabine; Hematopoietic Stem Cells; Humans; Myeloid Progenitor Cells; Retroviridae; Transduction, Genetic | 2005 |
Similar response rates and superior early progression-free survival with gemcitabine, dexamethasone, and cisplatin salvage therapy compared with carmustine, etoposide, cytarabine, and melphalan salvage therapy prior to autologous stem cell transplantation
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Carmustine; Cisplatin; Cytarabine; Deoxycytidine; Dexamethasone; Disease Progression; Disease-Free Survival; Etoposide; Female; Gemcitabine; Hematopoietic Stem Cell Transplantation; Hodgkin Disease; Humans; Male; Melphalan; Middle Aged; Prognosis; Recurrence; Retrospective Studies; Salvage Therapy; Treatment Outcome | 2006 |
Amsacrine combined with etoposide and high-dose methylprednisolone as salvage therapy in acute lymphoblastic leukemia in children.
Topics: Adolescent; Amsacrine; Antineoplastic Combined Chemotherapy Protocols; Child; Child, Preschool; Combined Modality Therapy; Cytarabine; Deoxycytidine; Dexamethasone; Drug Evaluation; Drug Synergism; Etoposide; Female; Filgrastim; Granulocyte Colony-Stimulating Factor; Humans; Idarubicin; Infant; Leukemia-Lymphoma, Adult T-Cell; Male; Methylprednisolone; Neoplasm, Residual; Peripheral Blood Stem Cell Transplantation; Precursor B-Cell Lymphoblastic Leukemia-Lymphoma; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prognosis; Recombinant Proteins; Remission Induction; Retrospective Studies; Salvage Therapy; Survival Analysis; Thiotepa; Topotecan; Treatment Outcome; Vidarabine; Vinblastine | 2005 |
The schedule-dependent effects of the novel antifolate pralatrexate and gemcitabine are superior to methotrexate and cytarabine in models of human non-Hodgkin's lymphoma.
Topics: Aminopterin; Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Cell Cycle; Cytarabine; Deoxycytidine; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Evaluation, Preclinical; Gemcitabine; Humans; In Vitro Techniques; Lymphoma, Non-Hodgkin; Methotrexate; Mice; Mice, SCID; Time Factors; Xenograft Model Antitumor Assays | 2006 |
Cytidine is a novel substrate for wild-type concentrative nucleoside transporter 2.
Topics: Amino Acid Substitution; Animals; Antimetabolites, Antineoplastic; Biological Transport; Chlorocebus aethiops; COS Cells; Cytarabine; Cytidine; Deoxycytidine; Dose-Response Relationship, Drug; Gemcitabine; Genotype; Kinetics; Male; Membrane Transport Proteins; Mice; Thymidine; Transfection; Tritium; Uridine | 2006 |
Gene transfer of cytidine deaminase protects myelopoiesis from cytidine analogs in an in vivo murine transplant model.
Topics: 3T3 Cells; Animals; Bone Marrow Transplantation; Colony-Forming Units Assay; Cytarabine; Cytidine Deaminase; Deoxycytidine; Gemcitabine; Gene Transfer Techniques; Graft Survival; Leukocyte Count; Mice; Models, Animal; Platelet Count; Recombinant Fusion Proteins | 2006 |
Acute transient encephalopathy following paclitaxel treatment in an adolescent with a recurrent suprasellar germinoma.
Topics: Adolescent; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Brain Diseases; Carboplatin; Cerebral Ventricle Neoplasms; Combined Modality Therapy; Consciousness Disorders; Cranial Irradiation; Cyclophosphamide; Cytarabine; Dacarbazine; Deoxycytidine; Etoposide; Female; Gemcitabine; Germinoma; Hematopoietic Stem Cell Transplantation; Humans; Hypophysectomy; Neoplasm Recurrence, Local; Organoplatinum Compounds; Oxaliplatin; Paclitaxel; Pituitary Neoplasms; Temozolomide; Thiotepa; Topotecan | 2008 |
Tandem high-dose chemotherapy and autologous stem cell transplantation in refractory/relapsed Hodgkin's lymphoma: a monocenter prospective study.
Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Carmustine; Cytarabine; Deoxycytidine; Disease-Free Survival; Etoposide; Female; Gemcitabine; Hodgkin Disease; Humans; Ifosfamide; Male; Melphalan; Middle Aged; Peripheral Blood Stem Cell Transplantation; Podophyllotoxin; Prospective Studies; Recurrence; Remission Induction; Retrospective Studies; Salvage Therapy; Survival Rate; Transplantation, Autologous; Vinblastine; Vinorelbine | 2007 |
A new, simple method for quantifying gemcitabine triphosphate in cancer cells using isocratic high-performance liquid chromatography.
Topics: Antimetabolites, Antineoplastic; Arabinofuranosylcytosine Triphosphate; Chromatography, High Pressure Liquid; Cytarabine; Deoxycytidine; Gemcitabine; HL-60 Cells; Humans; Leukemia, Lymphocytic, Chronic, B-Cell; Sensitivity and Specificity | 2006 |
Micro-array analysis of resistance for gemcitabine results in increased expression of ribonucleotide reductase subunits.
Topics: Antineoplastic Agents; Cell Line, Tumor; Cisplatin; Cladribine; Cytarabine; Deoxycytidine; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Gemcitabine; Gene Expression Regulation, Neoplastic; Glutamates; Guanine; Humans; Inhibitory Concentration 50; Oligonucleotide Array Sequence Analysis; Pemetrexed; Reverse Transcriptase Polymerase Chain Reaction; Ribonucleotide Reductases | 2006 |
The synergistic interaction of gemcitabine and cytosine arabinoside with the ribonucleotide reductase inhibitor triapine is schedule dependent.
Topics: Animals; Antimetabolites, Antineoplastic; Arabinofuranosylcytosine Triphosphate; Cytarabine; Deoxycytidine; DNA; Drug Synergism; Gemcitabine; Humans; Pyridines; Ribonucleotide Reductases; Thiosemicarbazones; Tumor Cells, Cultured | 2007 |
Antiproliferative effects of sapacitabine (CYC682), a novel 2'-deoxycytidine-derivative, in human cancer cells.
Topics: 5'-Nucleotidase; Antineoplastic Agents; Apoptosis; Arabinonucleosides; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Cell Survival; Cisplatin; Cytarabine; Cytosine; Deoxycytidine; Docetaxel; Drug Resistance, Neoplasm; Drug Synergism; Equilibrative Nucleoside Transporter 1; Gemcitabine; Gene Expression Regulation, Neoplastic; HCT116 Cells; HT29 Cells; Humans; Inhibitory Concentration 50; Molecular Structure; Neoplasms; Reverse Transcriptase Polymerase Chain Reaction; Taxoids | 2007 |
Preclinical toxicology (subacute and acute) and efficacy of a new squalenoyl gemcitabine anticancer nanomedicine.
Topics: Animals; Antineoplastic Agents; Cytarabine; Deoxycytidine; Drug Evaluation, Preclinical; Gemcitabine; Leukemia; Mice; Mice, Inbred DBA; Nanomedicine; Nanostructures; Squalene; Treatment Outcome | 2008 |
Anti proliferative activity of ELACY (CP-4055) in combination with cloretazine (VNP40101M), idarubicin, gemcitabine, irinotecan and topotecan in human leukemia and lymphoma cells.
Topics: Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Cell Line, Tumor; Cytarabine; Deoxycytidine; Drug Interactions; Drug Screening Assays, Antitumor; Gemcitabine; Humans; Hydrazines; Idarubicin; Irinotecan; Leukemia; Lymphoma; Sulfonamides; Topotecan | 2008 |
Gemcitabine and cytosine arabinoside cytotoxicity: association with lymphoblastoid cell expression.
Topics: Antineoplastic Agents; Blotting, Western; Cell Line, Tumor; Cytarabine; Deoxycytidine; Gemcitabine; Humans; Lymphocytes; Reverse Transcriptase Polymerase Chain Reaction; RNA Interference | 2008 |
Polymeric nanogels containing the triphosphate form of cytotoxic nucleoside analogues show antitumor activity against breast and colorectal cancer cell lines.
Topics: Animals; Antineoplastic Agents; Arabinofuranosylcytosine Triphosphate; Breast Neoplasms; Cell Cycle; Cell Death; Cell Line, Tumor; Cell Proliferation; Chemistry, Pharmaceutical; Colorectal Neoplasms; Cytarabine; Deoxycytidine; Drug Carriers; Drug Screening Assays, Antitumor; Flow Cytometry; Gemcitabine; Humans; Mice; Nanogels; Nucleosides; Polyethylene Glycols; Polyethyleneimine; Polymers; Polyphosphates | 2008 |
CP-4055 and CP-4126 are active in ara-C and gemcitabine-resistant lymphoma cell lines.
Topics: Cell Line, Tumor; Cell Membrane; Cytarabine; Deoxycytidine; Drug Resistance, Neoplasm; Gemcitabine; Humans; Lymphoma | 2009 |
Human multidrug resistance protein 7 (ABCC10) is a resistance factor for nucleoside analogues and epothilone B.
Topics: Acrylates; Animals; Antineoplastic Agents; Cell Line; Cytarabine; Deoxycytidine; Drug Resistance, Neoplasm; Epothilones; Fibroblasts; Gemcitabine; Humans; Mice; Multidrug Resistance-Associated Proteins; Polymers; Pyrimidine Nucleosides | 2009 |
Extending thymidine kinase activity to the catalytic repertoire of human deoxycytidine kinase.
Topics: Adenosine Diphosphate; Biocatalysis; Crystallography, X-Ray; Cytarabine; Deoxyadenosines; Deoxycytidine; Deoxycytidine Kinase; Deoxyguanosine; Gemcitabine; Humans; Kinetics; Mutant Proteins; Mutation; Protein Structure, Secondary; Static Electricity; Substrate Specificity; Thymidine; Thymidine Kinase | 2009 |
Intermediate dose gemcitabine-cisplatin combination chemotherapy without treatment delay for cytopenia followed by autografting--a new standard of care in relapsed or refractory Hodgkin lymphoma?
Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Blood Transfusion; Cisplatin; Combined Modality Therapy; Cytarabine; Deoxycytidine; Dexamethasone; Disease-Free Survival; Drug Administration Schedule; Drug Evaluation; Drug Resistance, Neoplasm; Etoposide; Female; Follow-Up Studies; Gemcitabine; Hematopoietic Cell Growth Factors; Hematopoietic Stem Cell Transplantation; Hodgkin Disease; Humans; Male; Methylprednisolone; Middle Aged; Neutropenia; Recurrence; Retrospective Studies; Salvage Therapy; Transplantation, Autologous; Young Adult | 2009 |
The role of HuR in gemcitabine efficacy in pancreatic cancer: HuR Up-regulates the expression of the gemcitabine metabolizing enzyme deoxycytidine kinase.
Topics: Antigens, Surface; Antimetabolites, Antineoplastic; Biomarkers, Tumor; Carcinoma, Pancreatic Ductal; Cytarabine; Deoxycytidine; Deoxycytidine Kinase; Drug Resistance, Neoplasm; ELAV Proteins; ELAV-Like Protein 1; Gemcitabine; Gene Expression Regulation, Neoplastic; Humans; Inactivation, Metabolic; Pancreatic Neoplasms; RNA-Binding Proteins; Time Factors; Treatment Outcome; Tumor Cells, Cultured; Up-Regulation | 2009 |
Cytosolic 5'-nucleotidase III (NT5C3): gene sequence variation and functional genomics.
Topics: 5'-Nucleotidase; Animals; Antimetabolites, Antineoplastic; Cell Line, Tumor; Chlorocebus aethiops; COS Cells; Cytarabine; Deoxycytidine; DNA; Gemcitabine; Genetic Variation; Glycoproteins; Haplotypes; Humans; Kinetics; Models, Genetic; Pharmacogenetics | 2009 |
Gemcitabine and arabinosylcytosin pharmacogenomics: genome-wide association and drug response biomarkers.
Topics: Antimetabolites, Antineoplastic; Biomarkers; Cytarabine; Deoxycytidine; Ethnicity; Gemcitabine; Genetic Variation; Genome-Wide Association Study; Humans; Inhibitory Concentration 50; Linkage Disequilibrium; Neoplasms; Oligonucleotide Array Sequence Analysis; Pharmacogenetics; Polymorphism, Single Nucleotide; RNA, Messenger | 2009 |
The combination of thalidomide, cyclophosphamide and dexamethasone is potentially useful in highly resistant Hodgkin's lymphoma.
Topics: Adult; Antibodies, Monoclonal; Antibodies, Monoclonal, Murine-Derived; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Carmustine; Cisplatin; Combined Modality Therapy; Cyclophosphamide; Cytarabine; Dacarbazine; Deoxycytidine; Dexamethasone; Doxorubicin; Drug Resistance, Neoplasm; Etoposide; Hodgkin Disease; Humans; Male; Mechlorethamine; Melphalan; Organoplatinum Compounds; Paclitaxel; Peripheral Blood Stem Cell Transplantation; Prednisolone; Prednisone; Procarbazine; Remission Induction; Rituximab; Salvage Therapy; Thalidomide; Topotecan; Transplantation, Autologous; Vidarabine; Vinblastine; Vincristine | 2010 |
Cell cycle effects of fatty acid derivatives of cytarabine, CP-4055, and of gemcitabine, CP-4126, as basis for the interaction with oxaliplatin and docetaxel.
Topics: Animals; Antineoplastic Agents; Cell Cycle; Cell Line, Tumor; Chemistry, Pharmaceutical; Cytarabine; Deoxycytidine; Docetaxel; Drug Design; Drug Screening Assays, Antitumor; Fatty Acids; Humans; Inhibitory Concentration 50; Mice; Neoplasm Metastasis; Neoplasm Transplantation; Organoplatinum Compounds; Oxaliplatin; Taxoids | 2010 |
Ethnic differences of two non-synonymous single nucleotide polymorphisms in CDA gene.
Topics: Alleles; Antimetabolites, Antineoplastic; Antirheumatic Agents; Asian People; Black or African American; Black People; Cytarabine; Cytidine Deaminase; Deoxycytidine; Gemcitabine; Gene Frequency; Genetic Predisposition to Disease; Genotype; Humans; Pharmacogenetics; Polymorphism, Genetic; Polymorphism, Single Nucleotide; White People | 2009 |
Interaction between DNA Polymerase lambda and anticancer nucleoside analogs.
Topics: Animals; Antineoplastic Agents; Cytarabine; Deoxycytidine; DNA; DNA Polymerase beta; DNA Repair; DNA Replication; DNA-Directed DNA Polymerase; Dose-Response Relationship, Drug; Gemcitabine; Humans; Kinetics; Mice; Models, Molecular; Nucleosides; Nucleotides | 2010 |
Incorporation of gemcitabine and cytarabine into DNA by DNA polymerase beta and ligase III/XRCC1.
Topics: Antimetabolites, Antineoplastic; Catalysis; Cytarabine; Deoxycytidine; DNA Damage; DNA Ligase ATP; DNA Ligases; DNA Polymerase beta; DNA Repair; DNA-Binding Proteins; Gemcitabine; Humans; Kinetics; Poly-ADP-Ribose Binding Proteins; Signal Transduction; Substrate Specificity; X-ray Repair Cross Complementing Protein 1; Xenopus Proteins | 2010 |
CD38 expression, function, and gene resequencing in a human lymphoblastoid cell line-based model system.
Topics: ADP-ribosyl Cyclase 1; Antimetabolites, Antineoplastic; Biomarkers; Blotting, Western; Cells, Cultured; Cytarabine; Deoxycytidine; Electrophoretic Mobility Shift Assay; Gemcitabine; Gene Expression Profiling; Humans; Lymphocytes; Models, Biological; Oligonucleotide Array Sequence Analysis; Polymorphism, Single Nucleotide; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger | 2010 |
Copy number variation and cytidine analogue cytotoxicity: a genome-wide association approach.
Topics: Antineoplastic Agents; Base Sequence; Cell Line; Cell Transformation, Viral; Cytarabine; Deoxycytidine; DNA Copy Number Variations; Female; Gemcitabine; Genome-Wide Association Study; Herpesvirus 4, Human; Histone-Lysine N-Methyltransferase; Humans; Inhibitory Concentration 50; Male; Nucleic Acid Amplification Techniques; Polymorphism, Single Nucleotide; Reproducibility of Results | 2010 |
The activity of the lipophilic nucleoside derivatives elacytarabine and CP-4126 in a panel of tumor cell lines resistant to nucleoside analogues.
Topics: Antineoplastic Agents; Caco-2 Cells; Cell Line, Tumor; Cytarabine; Deoxycytidine; Drug Resistance, Neoplasm; HT29 Cells; Humans; Pyrimidines | 2010 |
Induction of resistance to the lipophilic cytarabine prodrug elacytarabine (CP-4055) in CEM leukemic cells.
Topics: Antineoplastic Agents; Cell Line, Tumor; Cytarabine; Cytidine Deaminase; Deoxycytidine; Drug Resistance, Neoplasm; Gemcitabine; Humans; Leukemia; Nucleoside Deaminases; Polymerase Chain Reaction | 2010 |
Efficient overcoming of drug resistance to anticancer nucleoside analogs by nanodelivery of active phosphorylated drugs.
Topics: Animals; Antimetabolites, Antineoplastic; Apoptosis; Biological Transport; Cell Cycle; Cell Line, Tumor; Cell Survival; Chemistry, Pharmaceutical; Cytarabine; Deoxycytidine; Dose-Response Relationship, Drug; Drug Carriers; Drug Resistance; Drug Resistance, Neoplasm; Gels; Gemcitabine; Humans; Inhibitory Concentration 50; Mice; Mice, Inbred BALB C; Mice, Nude; Nanoparticles; Nanotechnology; Phosphorylation; Protein Tyrosine Phosphatase, Non-Receptor Type 22; Technology, Pharmaceutical; Time Factors; Tumor Burden; Xenograft Model Antitumor Assays | 2010 |
Ecotoxicity and genotoxicity assessment of cytotoxic antineoplastic drugs and their metabolites.
Topics: Animals; Antineoplastic Agents; Arabinofuranosyluracil; beta-Alanine; Chlorophyta; Cytarabine; Daphnia; Deoxycytidine; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Fluorouracil; Gemcitabine; Growth Inhibitors; Mutagenicity Tests; Mutagens; Pseudomonas; Salmonella; Toxicity Tests | 2010 |
Patient with HIV-associated plasmablastic lymphoma responding to bortezomib alone and in combination with dexamethasone, gemcitabine, oxaliplatin, cytarabine, and pegfilgrastim chemotherapy and lenalidomide alone.
Topics: Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Antiretroviral Therapy, Highly Active; Boronic Acids; Bortezomib; Cytarabine; Deoxycytidine; Dexamethasone; Filgrastim; Gemcitabine; Granulocyte Colony-Stimulating Factor; HIV Infections; Humans; Lenalidomide; Lymphoma, Large-Cell, Immunoblastic; Male; Neoplasm Staging; Organoplatinum Compounds; Oxaliplatin; Polyethylene Glycols; Pyrazines; Recombinant Proteins; Thalidomide; Young Adult | 2010 |
Inhibition of GST-pi nuclear transfer increases mantle cell lymphoma sensitivity to cisplatin, cytarabine, gemcitabine, bortezomib and doxorubicin.
Topics: Active Transport, Cell Nucleus; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Boronic Acids; Bortezomib; Cell Growth Processes; Cell Line, Tumor; Cisplatin; Cytarabine; Deoxycytidine; Doxorubicin; Drug Screening Assays, Antitumor; Gemcitabine; Glutathione S-Transferase pi; Humans; Lectins; Lymphoma, Mantle-Cell; Pyrazines | 2010 |
Wipe sampling procedure coupled to LC-MS/MS analysis for the simultaneous determination of 10 cytotoxic drugs on different surfaces.
Topics: Antineoplastic Agents; Camptothecin; Chromatography, Liquid; Cyclophosphamide; Cytarabine; Deoxycytidine; Doxorubicin; Epirubicin; Etoposide; Gemcitabine; Ifosfamide; Irinotecan; Methotrexate; Organophosphorus Compounds; Surface Properties; Tandem Mass Spectrometry; Vincristine | 2012 |
Metabolism and accumulation of the lipophilic deoxynucleoside analogs elacytarabine and CP-4126.
Topics: Antineoplastic Agents; Cell Line; Cytarabine; Deoxycytidine; Deoxycytidine Kinase; Dipyridamole; Drug Resistance, Neoplasm; Gemcitabine; Humans; Leukemia; Nucleoside Transport Proteins; Nucleotidases | 2012 |
Combination effects of digalloylresveratrol with arabinofuranosylcytosine and difluorodeoxycytidine in human leukemia and pancreatic cancer cells.
Topics: Antineoplastic Combined Chemotherapy Protocols; Cell Proliferation; Cytarabine; Deoxycytidine; Gallic Acid; Gemcitabine; HL-60 Cells; Humans; Leukemia; Pancreatic Neoplasms; Stilbenes; Tumor Stem Cell Assay | 2011 |
Preclinical development of the novel Chk1 inhibitor SCH900776 in combination with DNA-damaging agents and antimetabolites.
Topics: Antimetabolites; Antineoplastic Agents; Blotting, Western; Camptothecin; Cell Cycle Checkpoints; Cell Line; Cell Line, Tumor; Cell Proliferation; Cell Survival; Checkpoint Kinase 1; Cytarabine; Deoxycytidine; DNA Breaks, Double-Stranded; DNA Damage; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Drug Synergism; Flow Cytometry; Gemcitabine; Humans; Hydroxyurea; Irinotecan; Molecular Structure; Phosphorylation; Protein Kinase Inhibitors; Protein Kinases; Pyrazoles; Pyrimidines; Staurosporine | 2012 |
Stratification of nucleoside analog chemotherapy using 1-(2'-deoxy-2'-18F-fluoro-β-D-arabinofuranosyl)cytosine and 1-(2'-deoxy-2'-18F-fluoro-β-L-arabinofuranosyl)-5-methylcytosine PET.
Topics: Adenine Nucleotides; Animals; Arabinonucleosides; Cell Line, Tumor; Clofarabine; Cytarabine; Cytidine Deaminase; Cytosine; Deoxycytidine; Deoxycytidine Kinase; Fluorine Radioisotopes; Gemcitabine; Gene Expression Regulation, Neoplastic; Leukemia, Lymphoid; Mice; Positron-Emission Tomography; Treatment Outcome | 2012 |
High-dose chemotherapy in relapsed or refractory Hodgkin lymphoma patients: a reappraisal of prognostic factors.
Topics: Adolescent; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow Transplantation; Cisplatin; Combined Modality Therapy; Cytarabine; Deoxycytidine; Dexamethasone; Disease-Free Survival; Etoposide; Female; Fluorine Radioisotopes; Fluorodeoxyglucose F18; Gemcitabine; Hodgkin Disease; Humans; Ifosfamide; Kaplan-Meier Estimate; Male; Methylprednisolone; Middle Aged; Neoplasm Staging; Peripheral Blood Stem Cell Transplantation; Positron-Emission Tomography; Prognosis; Radiopharmaceuticals; Recurrence; Remission Induction; Retrospective Studies; Salvage Therapy; Transplantation Conditioning; Transplantation, Autologous; Treatment Outcome; Vinblastine; Vinorelbine; Young Adult | 2013 |
[First case in Spain of bacteremia by Methylobacterium thiocyanatum from Hickmann catheter in an immunosuppressed patient with Hodgkin's lymphoma].
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Bacteremia; Biofilms; Bleomycin; Carmustine; Catheter-Related Infections; Central Venous Catheters; Cisplatin; Cross Infection; Cytarabine; Dacarbazine; Deoxycytidine; Doxorubicin; Drug Resistance, Multiple, Bacterial; Equipment Contamination; Etoposide; Female; Gemcitabine; Gram-Negative Bacterial Infections; Hodgkin Disease; Humans; Immunocompromised Host; Melphalan; Methylobacterium; Prednisone; Ribotyping; Spain; Vinblastine | 2012 |
Sapacitabine, the prodrug of CNDAC, is a nucleoside analog with a unique action mechanism of inducing DNA strand breaks.
Topics: Animals; Antimetabolites, Antineoplastic; Arabinonucleosides; CHO Cells; Cricetinae; Cricetulus; Cytarabine; Cytosine; Deoxycytidine; DNA Breaks, Double-Stranded; DNA Repair; DNA-Binding Proteins; Gemcitabine; Homologous Recombination; Inhibitory Concentration 50; Prodrugs | 2012 |
Impressive activity of lenalidomide monotherapy in refractory angioimmunoblastic T-cell lymphoma: report of a case with long-term follow-up.
Topics: Angiogenesis Inhibitors; Antineoplastic Combined Chemotherapy Protocols; Clinical Trials as Topic; Combined Modality Therapy; Cytarabine; Deoxycytidine; Dexamethasone; Doxorubicin; Drug Resistance, Neoplasm; Drugs, Investigational; Follow-Up Studies; Gemcitabine; Humans; Ifosfamide; Immunologic Factors; Lenalidomide; Lymphoma, T-Cell, Peripheral; Male; Middle Aged; Organoplatinum Compounds; Polyethylene Glycols; Prednisone; Remission Induction; Salvage Therapy; Thalidomide; Vinblastine; Vinorelbine | 2013 |
Pharmacogenomics of gemcitabine metabolism: functional analysis of genetic variants in cytidine deaminase and deoxycytidine kinase.
Topics: Antimetabolites, Antineoplastic; Biotransformation; Catalysis; Cytarabine; Cytidine Deaminase; Deoxycytidine; Deoxycytidine Kinase; Gemcitabine; Genetic Variation; Genotype; Humans; Kinetics; Models, Biological; Nonlinear Dynamics; Pharmacogenetics; Phenotype; Phosphorylation; Recombinant Proteins; Substrate Specificity | 2013 |
F14512, a polyamine-vectorized anti-cancer drug, currently in clinical trials exhibits a marked preclinical anti-leukemic activity.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Blotting, Western; Boronic Acids; Bortezomib; Cell Proliferation; Cytarabine; Deoxycytidine; Doxorubicin; Fetal Blood; Flow Cytometry; Gemcitabine; Humans; Hydroxamic Acids; Immunoenzyme Techniques; Interleukin Receptor Common gamma Subunit; Leukemia, Myeloid, Acute; Mice; Mice, Inbred NOD; Mice, SCID; Podophyllotoxin; Pyrazines; Real-Time Polymerase Chain Reaction; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Survival Rate; Tumor Cells, Cultured; Vorinostat; Xenograft Model Antitumor Assays | 2013 |
Which regimen is better for stem cell mobilization of lymphoma patients?
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Cyclophosphamide; Cytarabine; Deoxycytidine; Doxorubicin; Female; Gemcitabine; Granulocyte Colony-Stimulating Factor; Hematopoietic Stem Cell Mobilization; Hematopoietic Stem Cell Transplantation; Humans; Lymphoma; Male; Methylprednisolone; Methylprednisolone Hemisuccinate; Middle Aged; Procarbazine; Retrospective Studies; Salvage Therapy; Treatment Outcome; Vinblastine; Vinorelbine | 2013 |
Discovery of genetic biomarkers contributing to variation in drug response of cytidine analogues using human lymphoblastoid cell lines.
Topics: Apoptosis; Cell Line, Tumor; Cytarabine; Deoxycytidine; Gemcitabine; Genetic Markers; Genome-Wide Association Study; Genotype; Humans; Linkage Disequilibrium; Mannosyltransferases; Polymorphism, Single Nucleotide; Regulatory Elements, Transcriptional; RNA Interference; RNA, Small Interfering | 2014 |
Selection of the best blood compartment to measure cytidine deaminase activity to stratify for optimal gemcitabine or cytarabine treatment.
Topics: Adult; Cost-Benefit Analysis; Cytarabine; Cytidine Deaminase; Deoxycytidine; Enzyme Assays; Female; Gemcitabine; Humans; Male; Middle Aged; Reproducibility of Results; Young Adult | 2014 |
Downregulation of deoxycytidine kinase in cytarabine-resistant mantle cell lymphoma cells confers cross-resistance to nucleoside analogs gemcitabine, fludarabine and cladribine, but not to other classes of anti-lymphoma agents.
Topics: Animals; Antibodies, Monoclonal, Murine-Derived; Antineoplastic Agents; Blotting, Western; Cell Line, Tumor; Cladribine; Clone Cells; Cytarabine; Deoxycytidine; Deoxycytidine Kinase; Down-Regulation; Drug Resistance, Neoplasm; Electrophoresis, Gel, Two-Dimensional; Gemcitabine; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Humans; Lymphoma, Mantle-Cell; Mass Spectrometry; Mice; Proteomics; Rituximab; Vidarabine; Xenograft Model Antitumor Assays | 2014 |
Reversible epigenetic regulation of 14-3-3σ expression in acquired gemcitabine resistance by uhrf1 and DNA methyltransferase 1.
Topics: 14-3-3 Proteins; CCAAT-Enhancer-Binding Proteins; Cell Line, Tumor; Cytarabine; Deoxycytidine; DNA; DNA (Cytosine-5-)-Methyltransferase 1; DNA (Cytosine-5-)-Methyltransferases; Drug Resistance, Neoplasm; Epigenesis, Genetic; Gemcitabine; Gene Expression Regulation, Neoplastic; Humans; MCF-7 Cells; Pancreatic Neoplasms; Ribonucleotide Reductases; Ubiquitin-Protein Ligases; Up-Regulation | 2014 |
[Cytidine].
Topics: Antineoplastic Agents; Arabinonucleosides; Cytarabine; Cytidine; Deoxycytidine; Gemcitabine; Humans; Neoplasms | 2015 |
Lethal toxicity after administration of azacytidine: implication of the cytidine deaminase-deficiency syndrome.
Topics: Antimetabolites, Antineoplastic; Azacitidine; Cytarabine; Cytidine Deaminase; Deoxycytidine; Fatal Outcome; Gemcitabine; Humans; Inactivation, Metabolic; Leukemia, Myeloid, Acute; Male; Middle Aged; Myelodysplastic Syndromes; Polymorphism, Single Nucleotide | 2015 |
IMP-GMP specific cytosolic 5'-nucleotidase regulates nucleotide pool and prodrug metabolism.
Topics: 5'-Nucleotidase; Antineoplastic Agents; Cell Survival; Cytarabine; Deoxycytidine; Dose-Response Relationship, Drug; Drug Resistance; Gemcitabine; Green Fluorescent Proteins; Guanosine Monophosphate; HEK293 Cells; Humans; Immunoblotting; Inosine Monophosphate; Nucleotides; Phosphorylation; Prodrugs; Substrate Specificity; Vidarabine | 2015 |
Gemcitabine/dexamethasone/cisplatin vs cytarabine/dexamethasone/cisplatin for relapsed or refractory aggressive-histology lymphoma: cost-utility analysis of NCIC CTG LY.12.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Canada; Cisplatin; Clinical Trials as Topic; Cost Savings; Cost-Benefit Analysis; Cytarabine; Deoxycytidine; Dexamethasone; Female; Gemcitabine; Hospital Charges; Hospital Costs; Humans; Lymphoma; Male; Middle Aged; Quality-Adjusted Life Years; Recurrence | 2015 |
Potent Sensitisation of Cancer Cells to Anticancer Drugs by a Quadruple Mutant of the Human Deoxycytidine Kinase.
Topics: Antineoplastic Agents; Cell Line, Tumor; Cytarabine; Deoxycytidine; Deoxycytidine Kinase; Drug Resistance, Neoplasm; Gemcitabine; HEK293 Cells; Humans; Mutation; Promoter Regions, Genetic | 2015 |
Effectiveness of a Closed-System Transfer Device in Reducing Surface Contamination in a New Antineoplastic Drug-Compounding Unit: A Prospective, Controlled, Parallel Study.
Topics: Antineoplastic Agents; Camptothecin; Cyclophosphamide; Cytarabine; Deoxycytidine; Drug Compounding; Drug Contamination; Fluorouracil; Ganciclovir; Gemcitabine; Humans; Ifosfamide; Irinotecan; Methotrexate; Occupational Exposure; Prospective Studies | 2016 |
Chk1 inhibition significantly potentiates activity of nucleoside analogs in TP53-mutated B-lymphoid cells.
Topics: Animals; Apoptosis; B-Lymphocytes; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Cell Survival; Checkpoint Kinase 1; Cytarabine; Deoxycytidine; Drug Screening Assays, Antitumor; Gemcitabine; Humans; Leukemia, Lymphocytic, Chronic, B-Cell; Mice; Mice, Transgenic; Mitosis; Mutation; Nucleosides; Pyrazoles; Pyrimidines; Signal Transduction; Tumor Suppressor Protein p53; Vidarabine | 2016 |
OCTN1 Is a High-Affinity Carrier of Nucleoside Analogues.
Topics: Animals; Antimetabolites, Antineoplastic; Child; CHO Cells; Cohort Studies; Cricetulus; Cytarabine; Deoxycytidine; Dipyridamole; Drug Resistance, Neoplasm; Gemcitabine; Gene Expression Profiling; HEK293 Cells; HeLa Cells; Humans; Leukemia, Myeloid, Acute; Organic Cation Transport Proteins; Symporters | 2017 |
The novel phospholipid mimetic KPC34 is highly active against preclinical models of Philadelphia chromosome positive acute lymphoblastic leukemia.
Topics: Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Cell Line, Tumor; Cytarabine; Deoxycytidine; DNA Damage; Dose-Response Relationship, Drug; Doxorubicin; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Gemcitabine; Glycerophosphates; Humans; Mice, Inbred C57BL; Mice, Transgenic; Neoplasm Transplantation; Philadelphia Chromosome; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Protein Kinase C; Random Allocation; Tumor Burden | 2017 |
Positively charged cyclodextrins as effective molecular transporters of active phosphorylated forms of gemcitabine into cancer cells.
Topics: Antimetabolites, Antineoplastic; Biological Transport; Breast Neoplasms; Cyclodextrins; Cytarabine; Deoxycytidine; Drug Resistance, Neoplasm; Female; Gemcitabine; Humans; Lymphoma, T-Cell; Models, Theoretical; Phosphorylation; Tumor Cells, Cultured | 2017 |
Monophosphorylation by deoxycytidine kinase affects apparent cellular uptake of decitabine in HCT116 colon cancer cells.
Topics: Antimetabolites, Antineoplastic; Azacitidine; Camptothecin; Colonic Neoplasms; Cytarabine; Decitabine; Deoxycytidine; Deoxycytidine Kinase; Equilibrative Nucleoside Transporter 1; Etoposide; Gemcitabine; HCT116 Cells; Humans; Irinotecan; Phosphorylation | 2017 |
Analysis of the prolonged infusion of DFP-10917, a deoxycytidine analog, as a therapeutic strategy for the treatment of human tumor xenografts in vivo.
Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Cytarabine; Deoxycytidine; DNA Breaks, Double-Stranded; DNA, Neoplasm; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; G2 Phase Cell Cycle Checkpoints; Gemcitabine; Humans; Infusions, Intravenous; Isoflurophate; Male; Mice; Mice, Inbred BALB C; Mice, Nude; Mice, SCID; Neoplasms; Paclitaxel; Xenograft Model Antitumor Assays | 2018 |
FF-10502, an Antimetabolite with Novel Activity on Dormant Cells, Is Superior to Gemcitabine for Targeting Pancreatic Cancer Cells.
Topics: Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Cytarabine; Deoxycytidine; Gemcitabine; Humans; Molecular Targeted Therapy; Pancreatic Neoplasms | 2018 |
TMSOTf assisted synthesis of 2'-deoxy-2'-[18F]fluoro-β-D-arabinofuranosylcytosine ([18F]FAC).
Topics: Cytarabine; Deoxycytidine; Deoxycytidine Kinase; Fluorine Radioisotopes; Gemcitabine; Mesylates; Radiochemistry; Radiopharmaceuticals; Trimethylsilyl Compounds | 2018 |
Structural basis for polymerase η-promoted resistance to the anticancer nucleoside analog cytarabine.
Topics: Antineoplastic Agents; Crystallization; Cytarabine; Cytidine; Deoxycytidine; DNA Repair; DNA Replication; DNA-Directed DNA Polymerase; Humans; Molecular Structure; X-Ray Diffraction | 2018 |
The economic impact of the transition from branded to generic oncology drugs.
Topics: Antineoplastic Agents; Cetuximab; Cisplatin; Cost-Benefit Analysis; Cytarabine; Deoxycytidine; Dexamethasone; Drug Costs; Drugs, Generic; Erlotinib Hydrochloride; Gemcitabine; Humans; Lung Neoplasms; Lymphoma; Randomized Controlled Trials as Topic; Vinorelbine | 2019 |
A high-throughput screen indicates gemcitabine and JAK inhibitors may be useful for treating pediatric AML.
Topics: Adult; Animals; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow; Bone Marrow Transplantation; Cell Line, Tumor; Child; Child, Preschool; Cytarabine; Deoxycytidine; Disease-Free Survival; Female; Gemcitabine; High-Throughput Screening Assays; Humans; Infant; Janus Kinase Inhibitors; Leukemia, Experimental; Leukemia, Myeloid, Acute; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Taxoids; Whole-Body Irradiation; Xenograft Model Antitumor Assays; Young Adult | 2019 |
Development and validation of a liquid chromatography tandem mass spectrometry quantification method for 14 cytotoxic drugs in environmental samples.
Topics: Antineoplastic Agents; Chromatography, High Pressure Liquid; Cyclophosphamide; Cytarabine; Deoxycytidine; Doxorubicin; Environmental Pollutants; Gemcitabine; Occupational Exposure; Paclitaxel; Sensitivity and Specificity; Tandem Mass Spectrometry | 2020 |
Allogenic hematopoietic stem cell transplantation for prolonged bone marrow aplasia after chimeric antigen receptor (CAR) T-cell therapy for relapsed diffuse large B-cell lymphoma.
Topics: Adrenal Cortex Hormones; Allografts; Anemia, Aplastic; Antibodies, Monoclonal, Humanized; Antigens, CD19; Antineoplastic Combined Chemotherapy Protocols; Biological Products; Carmustine; Combined Modality Therapy; Cyclophosphamide; Cytarabine; Deoxycytidine; Doxorubicin; Etoposide; Gemcitabine; Hematopoietic Stem Cell Transplantation; Humans; Immunotherapy, Adoptive; Lymphoma, Large B-Cell, Diffuse; Male; Melphalan; Middle Aged; Oxaliplatin; Prednisone; Recurrence; Rituximab; Salvage Therapy; Transplantation, Autologous; Vincristine | 2020 |
Assessment of Anti-Tumor potential and safety of application of Glutathione stabilized Gold Nanoparticles conjugated with Chemotherapeutics.
Topics: Chromatography, High Pressure Liquid; Cytarabine; Deoxycytidine; Doxorubicin; Gemcitabine; Glutathione; Gold; Humans; MCF-7 Cells; Metal Nanoparticles; Microscopy, Electron, Transmission; Neoplasms; Osteoblasts; Telomerase | 2020 |
sATP‑binding cassette subfamily G member 2 enhances the multidrug resistance properties of human nasal natural killer/T cell lymphoma side population cells.
Topics: Antineoplastic Agents; Asparaginase; ATP Binding Cassette Transporter, Subfamily G, Member 2; Cell Line, Tumor; Cell Proliferation; Cytarabine; Deoxycytidine; Doxorubicin; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Gemcitabine; Gene Expression Regulation, Neoplastic; Humans; Lymphoma, Extranodal NK-T-Cell; Neoplasm Proteins | 2020 |
Assessment of efficacy of postinfusion tubing flushing in reducing risk of cytotoxic contamination.
Topics: Antineoplastic Agents; Chromatography, High Pressure Liquid; Cytarabine; Decontamination; Deoxycytidine; Gemcitabine; Health Personnel; Humans; Infusions, Parenteral; Occupational Exposure; Paclitaxel | 2020 |
Exosomes secreted from cancer-associated fibroblasts elicit anti-pyrimidine drug resistance through modulation of its transporter in malignant lymphoma.
Topics: Animals; Antimetabolites, Antineoplastic; Cancer-Associated Fibroblasts; Cell Line, Tumor; Cell Proliferation; Cytarabine; Deoxycytidine; Drug Resistance, Neoplasm; Equilibrative-Nucleoside Transporter 2; Exosomes; Gemcitabine; Humans; Lymphoma; Male; Mice; Mice, Inbred NOD; Mice, SCID; MicroRNAs; Primary Cell Culture; Tumor Microenvironment; Xenograft Model Antitumor Assays | 2021 |
Idiopathic hyperammonemic encephalopathy secondary to gemcitabine-cisplatin treatment.
Topics: Antineoplastic Agents; Asparaginase; Brain Diseases; Cisplatin; Cytarabine; Deoxycytidine; Fluorouracil; Gemcitabine; Humans; Hyperammonemia; Neurotoxicity Syndromes | 2022 |