Compounds > cytarabine

cytarabine and bryostatin 1

cytarabine has been researched along with bryostatin 1 in 18 studies

Research

Studies (18)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's15 (83.33)18.2507
2000's3 (16.67)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Gewirtz, DA; Grant, S; Jarvis, WD; Lin, PS; Pettit, GR; Swerdlow, PS; Traylor, RS; Turner, AJ; Wallace, HJ1
Grant, S; Jarvis, WD; Pettit, GR; Turner, AJ; Wallace, HJ1
Boise, L; Grant, S; Howe, C; McCrady, C; Pettit, GR; Turner, A; Westin, E1
Gewirtz, DA; Grant, S; Jarvis, WD; Pettit, GR; Povirk, LF; Traylor, RS; Turner, AJ1
Bear, HD; Chelliah, J; Freemerman, AJ; Grant, S; Jarvis, WD; Mikkelsen, R; Rao, AS1
Freemerman, AJ; Grant, S; Jarvis, WD; Kramer, L; Turner, AJ; Wang, Z1
Grant, S1
Chelliah, J; Freemerman, AJ; Grant, S; Jarvis, WD; Wu-Pong, S1
Bartimole, TM; Dent, P; Freemerman, AJ; Grant, S; Jarvis, WD; Kramer, LB; Krystal, G; Vrana, JA; Wang, S1
Grant, S; Jarvis, WD; Rao, AS; Vrana, JA; Wang, Z1
Alton, P; Elgie, AW; Noordhuis, P; Peters, GJ; Sargent, JM; Taylor, CG; Williamson, CJ1
Bittman, R; Dent, P; Erukulla, RK; Fornari, FA; Grant, S; Jarvis, WD; Schwartz, GK; Tombes, RM1
Grant, S; Jarvis, WD1
Dent, P; Grant, S; Kramer, LB; Povirk, LF; Saunders, AM; Vrana, JA; Zhang, XF1
Gschwendt, M; Häussermann, S; Johannes, FJ; Kittstein, W; Marks, F; Rincke, G1
Dai, Y; Grant, S; Wang, S; Wang, Z1
Andreeff, M; Cragg, LH; Feldman, E; Grant, S; Kramer, L; Murgo, A; Roberts, J; Roboz, G; Tombes, MB; Winning, M1
Grant, S; Wang, S; Wang, Z1

Reviews

2 review(s) available for cytarabine and bryostatin 1

ArticleYear
Modulation of ara-C induced apoptosis in leukemia by the PKC activator bryostatin 1.
    Frontiers in bioscience : a journal and virtual library, 1997, Jun-01, Volume: 2

    Topics: Antimetabolites, Antineoplastic; Antineoplastic Agents; Apoptosis; Bryostatins; Cell Differentiation; Cytarabine; Drug Interactions; Genes, myc; Humans; Macrolides; Proto-Oncogene Mas; Proto-Oncogene Proteins c-bcl-2; Signal Transduction

1997
Modulation of drug-induced apoptosis by interruption of the protein kinase C signal transduction pathway: a new therapeutic strategy.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 1996, Volume: 2, Issue:12

    Topics: Antineoplastic Agents; Apoptosis; Bryostatins; Cytarabine; Drug Synergism; Enzyme Inhibitors; Humans; Lactones; Macrolides; Neoplasms; Protein Kinase C; Protein-Tyrosine Kinases; Signal Transduction

1996

Trials

1 trial(s) available for cytarabine and bryostatin 1

ArticleYear
Phase I trial and correlative laboratory studies of bryostatin 1 (NSC 339555) and high-dose 1-B-D-arabinofuranosylcytosine in patients with refractory acute leukemia.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2002, Volume: 8, Issue:7

    Topics: Acute Disease; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Bryostatins; Cytarabine; Female; Humans; Infusions, Intravenous; Lactones; Leukemia, Myeloid; Macrolides; Male; Middle Aged; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Protein Kinase C; Tumor Cells, Cultured

2002

Other Studies

15 other study(ies) available for cytarabine and bryostatin 1

ArticleYear
Potentiation of the activity of 1-beta-D-arabinofuranosylcytosine by the protein kinase C activator bryostatin 1 in HL-60 cells: association with enhanced fragmentation of mature DNA.
    Cancer research, 1992, Nov-15, Volume: 52, Issue:22

    Topics: Adenosine Triphosphate; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Bryostatins; Calcitriol; Cytarabine; DNA; DNA Damage; DNA, Neoplasm; Drug Synergism; Humans; Lactones; Leukemia, Promyelocytic, Acute; Macrolides; NAD; Protein Kinase C; Thymidine; Time Factors; Tritium; Tumor Cells, Cultured

1992
Effects of bryostatin 1 and rGM-CSF on the metabolism of 1-beta-D-arabinofuranosylcytosine in human leukaemic myeloblasts.
    British journal of haematology, 1992, Volume: 82, Issue:3

    Topics: Antineoplastic Agents; Arabinofuranosylcytosine Triphosphate; Bryostatins; Cytarabine; Drug Interactions; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; Lactones; Leukemia, Myeloid, Acute; Macrolides; Recombinant Proteins; Time Factors

1992
In vitro effects of bryostatin 1 on the metabolism and cytotoxicity of 1-beta-D-arabinofuranosylcytosine in human leukemia cells.
    Biochemical pharmacology, 1991, Jul-25, Volume: 42, Issue:4

    Topics: Antineoplastic Agents; Arabinofuranosylcytosine Triphosphate; Bryostatins; Cell Count; Cytarabine; Diterpenes; DNA, Neoplasm; Humans; Kinetics; Lactones; Leukemia, Experimental; Leukemia, Myeloid; Macrolides; Phorbol 12,13-Dibutyrate; Phosphorylation; Terpenes; Time Factors; Tumor Cells, Cultured

1991
Effects of bryostatin 1 and other pharmacological activators of protein kinase C on 1-[beta-D-arabinofuranosyl]cytosine-induced apoptosis in HL-60 human promyelocytic leukemia cells.
    Biochemical pharmacology, 1994, Mar-02, Volume: 47, Issue:5

    Topics: Antineoplastic Agents; Apoptosis; Bryostatins; Cytarabine; DNA Damage; DNA, Neoplasm; Dose-Response Relationship, Drug; Drug Synergism; Humans; Lactones; Leukemia, Myeloid; Macrolides; Protein Kinase C; Tumor Cells, Cultured

1994
Effect of AS101 on bryostatin 1-mediated differentiation induction, cell cycle arrest, and modulation of drug-induced apoptosis in human myeloid leukemia cells.
    Leukemia, 1996, Volume: 10, Issue:7

    Topics: Antineoplastic Agents; Apoptosis; Blotting, Western; Bryostatins; Calcium; Cell Adhesion; Cell Cycle; Cell Differentiation; Cyclin-Dependent Kinase Inhibitor p21; Cyclins; Cytarabine; DNA Damage; Drug Synergism; Ethylenes; HL-60 Cells; Humans; Lactones; Leukemia, Promyelocytic, Acute; Macrolides; Macrophage-1 Antigen; Protein Kinase C; Proto-Oncogene Proteins c-myc; Tumor Stem Cell Assay

1996
Modulation of protein kinase C activity and calcium-sensitive isoform expression in human myeloid leukemia cells by bryostatin 1: relationship to differentiation and ara-C-induced apoptosis.
    Experimental cell research, 1996, Oct-10, Volume: 228, Issue:1

    Topics: Antimetabolites, Antineoplastic; Apoptosis; Bryostatins; Calcium; Carcinogens; Cell Differentiation; Cytarabine; Diterpenes; Enzyme Activation; HL-60 Cells; Humans; Isoenzymes; Lactones; Macrolides; Protein Kinase C; Signal Transduction; Terpenes; Tumor Cells, Cultured

1996
Potentiation of ara-C-induced apoptosis by the protein kinase C activator bryostatin 1 in human leukemia cells (HL-60) involves a process dependent upon c-Myc.
    Biochemical pharmacology, 1997, Sep-01, Volume: 54, Issue:5

    Topics: Antineoplastic Agents; Apoptosis; Bryostatins; Cell Cycle; Cytarabine; Diterpenes; DNA Fragmentation; Drug Synergism; Enzyme Activation; HL-60 Cells; Humans; Kinetics; Lactones; Macrolides; Oligonucleotides, Antisense; Phorbol 12,13-Dibutyrate; Protein Kinase C; Proto-Oncogene Proteins c-myc; Terpenes; Tetradecanoylphorbol Acetate; Thionucleotides

1997
Agents that down-regulate or inhibit protein kinase C circumvent resistance to 1-beta-D-arabinofuranosylcytosine-induced apoptosis in human leukemia cells that overexpress Bcl-2.
    Molecular pharmacology, 1997, Volume: 52, Issue:6

    Topics: Alkaloids; Antimetabolites, Antineoplastic; Antineoplastic Agents; Apoptosis; Blotting, Western; Bryostatins; Cytarabine; DNA, Neoplasm; Down-Regulation; Drug Resistance, Neoplasm; Drug Synergism; Endopeptidases; Enzyme Inhibitors; HL-60 Cells; Humans; Lactones; Macrolides; Phosphorylation; Protein Kinase C; Proto-Oncogene Proteins c-bcl-2; Staurosporine

1997
Effects of bryostatin 1 and calcium ionophore (A23187) on apoptosis and differentiation in human myeloid leukemia cells (HL-60) following 1-beta-D-arabinofuranosylcytosine exposure.
    International journal of oncology, 1998, Volume: 12, Issue:4

    Topics: Acetamides; Antineoplastic Agents; Apoptosis; Bryostatins; Calcimycin; Calcium; Cell Differentiation; Cytarabine; DNA Fragmentation; HL-60 Cells; Humans; Lactones; Macrolides; Tetradecanoylphorbol Acetate

1998
Modulation of resistance to ara-C by bryostatin in fresh blast cells from patients with AML.
    Leukemia research, 1998, Volume: 22, Issue:4

    Topics: Acute Disease; Antineoplastic Agents; Arabinofuranosylcytosine Triphosphate; Bryostatins; Cell Death; Cytarabine; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Humans; Lactones; Leukemia, Myeloid; Leukocytes, Mononuclear; Macrolides; Tetrazolium Salts; Thiazoles

1998
Evidence for involvement of mitogen-activated protein kinase, rather than stress-activated protein kinase, in potentiation of 1-beta-D-arabinofuranosylcytosine-induced apoptosis by interruption of protein kinase C signaling.
    Molecular pharmacology, 1998, Volume: 54, Issue:5

    Topics: Antimetabolites, Antineoplastic; Antineoplastic Agents; Apoptosis; Bryostatins; Calcium-Calmodulin-Dependent Protein Kinases; Cytarabine; Diglycerides; Down-Regulation; Enzyme Activation; Enzyme Inhibitors; Flavonoids; HL-60 Cells; Humans; Lactones; Macrolides; Protein Kinase Inhibitors; Protein Kinases; Signal Transduction; Sphingosine; Stereoisomerism

1998
Inhibition of protein kinase C activator-mediated induction of p21CIP1 and p27KIP1 by deoxycytidine analogs in human leukemia cells: relationship to apoptosis and differentiation.
    Biochemical pharmacology, 1999, Jul-01, Volume: 58, Issue:1

    Topics: Antimetabolites, Antineoplastic; Apoptosis; Bryostatins; Cell Cycle Proteins; Cell Differentiation; Cyclin-Dependent Kinase Inhibitor p21; Cyclin-Dependent Kinase Inhibitor p27; Cyclins; Cytarabine; Deoxycytidine; Drug Interactions; Enzyme Activation; Gemcitabine; Humans; Lactones; Leukemia; Macrolides; Microtubule-Associated Proteins; Mitogens; Protein Kinase C; Tetradecanoylphorbol Acetate; Tumor Suppressor Proteins; U937 Cells

1999
Proteolytic cleavage of protein kinase Cmu upon induction of apoptosis in U937 cells.
    FEBS letters, 1999, Dec-03, Volume: 462, Issue:3

    Topics: Apoptosis; Bryostatins; Caspase 3; Caspases; Cell-Free System; Cycloheximide; Cytarabine; Fructose-Bisphosphate Aldolase; Humans; Lactones; Macrolides; Oligopeptides; Protein Kinase C; Recombinant Proteins; Time Factors; Tumor Necrosis Factor-alpha; U937 Cells

1999
Bryostatin 1 increases 1-beta-D-arabinofuranosylcytosine-induced cytochrome c release and apoptosis in human leukemia cells ectopically expressing Bcl-x(L).
    The Journal of pharmacology and experimental therapeutics, 2002, Volume: 301, Issue:2

    Topics: Antineoplastic Agents; Apoptosis; bcl-X Protein; Bryostatins; Cytarabine; Cytochrome c Group; Drug Interactions; Humans; Lactones; Leukemia; Macrolides; Proto-Oncogene Proteins c-bcl-2; Tumor Cells, Cultured

2002
Bryostatin 1 and UCN-01 potentiate 1-beta-D-arabinofuranosylcytosine-induced apoptosis in human myeloid leukemia cells through disparate mechanisms.
    Molecular pharmacology, 2003, Volume: 63, Issue:1

    Topics: Alkaloids; Antineoplastic Agents; Apoptosis; Apoptosis Regulatory Proteins; Bryostatins; Carrier Proteins; Caspases; Cytarabine; Cytochrome c Group; Drug Synergism; Enzyme Activation; Gene Deletion; HL-60 Cells; Humans; Indoles; Intracellular Signaling Peptides and Proteins; Lactones; Leukemia, Myeloid; Macrolides; Maleimides; Mitochondrial Proteins; Mutation; Phosphorylation; Protein Kinase C; Proto-Oncogene Proteins c-bcl-2; Receptors, Tumor Necrosis Factor; Staurosporine; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha; U937 Cells

2003