cytarabine has been researched along with arabinofuranosyluracil in 106 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 68 (64.15) | 18.7374 |
| 1990's | 24 (22.64) | 18.2507 |
| 2000's | 3 (2.83) | 29.6817 |
| 2010's | 10 (9.43) | 24.3611 |
| 2020's | 1 (0.94) | 2.80 |
| Authors | Studies |
|---|---|
| De Clercq, E; Descamps, J; Kulikowski, T; Shugar, D; Zawadzki, Z | 1 |
| Guinan, M; Huang, N; Miller, GJ; Smith, M | 1 |
| Mihara, S; Moffatt, JG; Okabayashi, T | 1 |
| Mihara, S; Moffatt, JG; Okabayashi, T; Repke, DB | 1 |
| Gizoni, C; Gordon, C; Kreis, W; Woodcock, T | 1 |
| Benvenuto, J; Brown, NS; Buckels, D; Freireich, EJ; Ho, DH; McCredie, KB | 1 |
| Rustum, YM | 1 |
| Hilliard, S; Peck, C; Roberts, D; Wingo, W | 1 |
| Chu, CK; Fox, JJ; Reichman, U; Watanabe, KA | 1 |
| Aherne, GW; Marks, VM; Piall, EM | 1 |
| Hutchison, DJ; Mehta, BM | 1 |
| Gordon, C; Greenspan, A; Kreis, W; Woodcock, T | 1 |
| Darzynkiewicz, E; Dworak, A; Remin, M; Shugar, D | 1 |
| Chuang, LF; Chuang, RY | 1 |
| Ashida, N; Baba, M; Ikeda, T; Machida, H; Sakata, S; Shigeta, S | 1 |
| Büchner, T; Hiddemann, W; Kewer, U; Reuter, C; Rolf, C; Schleyer, E; Uhrmeister, C; Unterhalt, M; Wörmann, B; Zühlsdorf, M | 1 |
| Capizzi, RL; Chandrasekaran, B; Kute, TE | 1 |
| Akerman, S; Arlin, Z; Baskind, P; Budman, DR; DeAngelis, L; Feldman, EJ; Kreis, W; Lesser, M | 1 |
| Budman, DR; Kreis, W | 1 |
| Fourel, I; Fox, JJ; Hantz, O; Jacquet, C; Li, J; Trépo, C | 1 |
| King, DH | 1 |
| Akerman, S; Chan, K; Dantis, E; DeAngelis, LM; Kreis, W | 1 |
| Damon, LE; Linker, CA; Plunkett, W | 1 |
| Balasubramaniam, NK; Gentry, GA; Veerisetty, V | 1 |
| Cleary, SM; Howell, SB; Kirmani, S; Mowry, J; Zimm, S | 1 |
| Zimmerman, CL | 1 |
| Chomel, B; Fourel, I; Fox, JJ; Hantz, O; Jacquet, C; Trepo, C; Watanabe, KA | 1 |
| Adachi, S; Hirooka, C; Ichijo, M; Kiyozuka, Y; Noda, T; Oku, M; Yamamoto, T | 1 |
| Lasorella, A; Riccardi, A; Riccardi, R; Servidei, T | 1 |
| Aherne, GW; Dawson, VM; Ford, J; Kees, UR; Piall, E | 1 |
| Capizzi, RL; Chandrasekaran, B; Dimling, J; Kute, TE; Morgan, T | 1 |
| Hassan, FM; Pesce, AJ; Pruemer, JM; Warner, A; Wermeling, JR | 1 |
| Domae, N; Kagawa, D; Nakamura, T; Sasada, M; Sugiyama, M; Uchida, M; Uchino, H; Ueda, T; Ueda, Y | 1 |
| Capizzi, RL; Wang, LM; White, JC; Woodward, CN | 1 |
| Engle, KK; Higuchi, T; Liversidge, GG; Nishihata, T | 1 |
| Campbell, NL; Matthews, TR; Smee, DF | 1 |
| Cheng, YC; Chiou, JF; Huang, ES; Mar, EC | 1 |
| Burns, WH; Chen, MS; Ghazzouli, I; McLaren, C; Saral, R | 1 |
| Machida, H | 1 |
| Rollinson, EA | 1 |
| Fox, JJ; Harada, K; Matulic-Adamic, J; Price, RW; Schinazi, RF; Watanabe, KA | 1 |
| Bentele, B; Betz, JL; Mitchell, DH; Pizer, LI | 1 |
| Capizzi, RL; Cooper, MR; Cuttner, J; Davis, R; Dillman, R; Dupre, E; Ellison, RR; Major, WB; McIntyre, OR; Powell, B | 1 |
| Muus, P; Punt, K; Roelofs, JM; van Prooijen, HC | 1 |
| Griffin, JD; Kufe, DW; Spriggs, DR | 1 |
| Bauch, HJ; Pielken, HJ; Preusser, P | 1 |
| Sougawa, M; Tanaka, Y; Yoshii, G | 1 |
| Preisler, HD; Riva, C; Rustum, YM | 1 |
| Avramis, VI; Powell, W | 1 |
| Chen, MS; Oshana, SC; Van Nostrand, M | 1 |
| Balzarini, J | 1 |
| Colly, LP; Edelbroek, PM; Honders, W; vd Hoorn, F; Willemze, R | 1 |
| Capizzi, RL; Cheng, E; Cheng, YC; Kute, T; Rathmell, JP; White, JC; Yang, JL | 1 |
| Chou, TC; Fanucchi, MP; Fox, JJ; Watanabe, KA | 1 |
| Capizzi, RL; Cheng, EH; Cheng, YC; Kute, T; Yang, JL | 1 |
| Calnek, BW; Schat, KA; Schinazi, RF | 1 |
| Agarwal, RP; Lopez, JA | 1 |
| Bouchard, J; Chabot, GG; Momparler, RL | 1 |
| Friedman-Kien, AE; Klein, RJ | 1 |
| Hsiung, GD; Mayo, DR | 1 |
| Chou, TC; Feinberg, A; Fox, JJ; Philips, FS; Su, TL; Vidal, PM; Watanabe, KA | 1 |
| Cheng, YC; Lin, JC; Pagano, JS; Smith, MC | 1 |
| Kodama, K; Kuninaka, A; Morozumi, M; Sato, T; Yoshino, H | 1 |
| Evans, WE; Sinkule, JA | 1 |
| Chatterji, D; Collins, JM; Miser, J; Poplack, DG; Zimm, S | 1 |
| Agarwal, RP; Beardsley, GP; Krikorian, JG; Lopez, JA; Mortara, RW | 1 |
| Nahmias, AJ; Peters, J; Schinazi, RF; Sokol, MK | 1 |
| Cortese, M; Higuchi, T; Liversidge, GG; Nishihata, T; Shaffer, R | 1 |
| Bjornsson, T; Capizzi, RL; Cheng, E; Cheng, YC; Sahasrabudhe, D; Tan, RS; Yang, JL | 1 |
| Fox, JJ; Last-Barney, K; Merluzzi, VJ | 1 |
| Howell, SB; King, ME; Pfeifle, CE | 1 |
| Akiyama, Y; Ando, S; Johno, I; Kagawa, D; Nakamura, T; Sasada, M; Uchino, H; Ueda, T | 1 |
| Bunch, C; Grahame-Smith, DG; Harris, AL; Potter, CG | 1 |
| Grahame-Smith, DG; Harris, AL | 1 |
| Marquardt, H; Westendorf, J | 1 |
| Burchenal, JH; Chou, TC; Fox, JJ; Lokys, L; Smith, RS; Su, TL; Watanabe, KA | 1 |
| Hirobe, M; Makino, Y; Matsubara, Y; Watanabe, K | 1 |
| Breithaupt, H; Eckhardt, T; Löffler, H; Pralle, H; Schick, J; von Hattingberg, M | 1 |
| Braun, TJ; Burchenal, JH; Chou, TC; Fox, JJ; Philips, FS; Schmid, FA; Su, TL; Watanabe, KA | 1 |
| Fox, JJ; Philips, FS; Price, RW; Rottenberg, DA; Saito, Y; Su, TL; Watanabe, KA | 1 |
| Drenthe-Schonk, A; Haanen, C; Linssen, P; Wessels, H | 1 |
| Breithaupt, H; Schick, J | 1 |
| Mazrimas, JA; Pallavicini, MG | 1 |
| Braess, J; Hiddemann, W; Kaufmann, C; Ramsauer, B; Schleyer, E; Schüssler, M; Unterhalt, M; Wilde, S | 1 |
| Burk, M; Fartash, K; Schneider, W; Volmer, M | 1 |
| Kanno, M; Kobayashi, K; Matano, S; Matuda, T; Nakamura, S; Ohtake, S; Okabe, Y; Okumura, H; Takeda, Y; Yoshida, T | 1 |
| Klaus, G; Ludwig, R; Mehls, O; Pöschl, JM; Querfeld, U | 1 |
| Gordon, M | 1 |
| Büchner, T; Hiddemann, W; Kern, W; Schleyer, E; Unterhalt, M | 1 |
| Avramis, VI; Periclou, AP | 1 |
| Arning, M; Burk, M; Fartash, K; Heyll, A; Schneider, W; Volmer, M | 1 |
| Fukushima, T; Gotoh, N; Kishi, S; Masada, M; Matsuyama, S; Nakamura, T; Tsutani, H; Ueda, T; Yamauchi, T | 1 |
| Balzarini, J; Baraldi, PG; Buzzoni, V; De Clercq, E; Durini, E; Karlsson, A; Manfredini, S; Thelander, L; Vertuani, S | 1 |
| Bousquet, B; Deschamps, F; Dombret, H; Gourmel, B; Houzé, P | 1 |
| Buck, S; Ge, Y; Jensen, TL; Matherly, LH; Ravindranath, Y; Stout, ML; Tatman, DA; Taub, JW; Thomas, RL | 1 |
| Ehninger, G; Hiddemann, W; Illmer, T; Karsch, C; Kiani, A; Lindner, LH; Ostermann, H; Platzbecker, U; Schleyer, E; Würfel, M | 1 |
| Cain, M; Cull, GM; Hackett, LP; Ilett, KF; Radeski, D | 1 |
| Blaha, L; Dott, W; Kovalova, L; Zounkova, R | 1 |
| Alauddin, M; Chan, PC; Chang, WT; Chang, WY; Chen, CL; Chen, FD; Lin, WJ; Liu, RS; Wang, HE; Wu, CY | 1 |
| Jiang, S; Qiao, X; Shao, Y; Shi, W; Tang, J; Xie, X; Zhang, X; Zhou, X | 1 |
| Kambhampati, SP; Kannan, RM; Lesniak, WG; Mishra, MK; Sk, UH; Zhang, F | 1 |
| Hara, S; Jimi, S; Matsumoto, T; Ogata, K; Takamatsu, Y; Tamura, K; Uchiyama, M | 1 |
| Jiang, X; Liang, D; Wang, W; Yin, S | 1 |
| Andrei, G; Coen, N; Duraffour, S; Snoeck, R; Topalis, D | 1 |
| Qian, W; Wang, D; Xiao, Q; Yang, J; Yang, W | 1 |
| Berda-Haddad, Y; Ciccolini, J; Costello, R; Donnette, M; Fanciullino, R; Farnault, L; Giocanti, M; Hau, LTT; Lacarelle, B; Ouafik, L; Solas, C; Venton, G | 1 |
2 review(s) available for cytarabine and arabinofuranosyluracil
| Article | Year |
|---|---|
Fluorinated pyrimidines: a new change for old drugs.
Topics: Acquired Immunodeficiency Syndrome; Antiviral Agents; Arabinofuranosyluracil; Bone Marrow Transplantation; Cytarabine; Cytomegalovirus; Cytomegalovirus Infections; Pyrimidines; Structure-Activity Relationship | 1991 |
Dose-related pharmacologic effects of high-dose ara-C and its self-potentiation.
Topics: Aging; Animals; Arabinofuranosyluracil; Biological Transport; Bone Marrow; Cell Line; Cell Membrane; Clinical Trials as Topic; Cytarabine; DNA; Dose-Response Relationship, Drug; Drug Resistance; Half-Life; Humans; Interphase; Leukemia; Leukemia L5178; Time Factors | 1985 |
4 trial(s) available for cytarabine and arabinofuranosyluracil
| Article | Year |
|---|---|
Synergy between high-dose cytarabine and asparaginase in the treatment of adults with refractory and relapsed acute myelogenous leukemia--a Cancer and Leukemia Group B Study.
Topics: Antineoplastic Combined Chemotherapy Protocols; Arabinofuranosyluracil; Asparaginase; Cytarabine; Humans; Leukemia, Myeloid, Acute | 1988 |
Dose-related pharmacologic effects of high-dose ara-C and its self-potentiation.
Topics: Aging; Animals; Arabinofuranosyluracil; Biological Transport; Bone Marrow; Cell Line; Cell Membrane; Clinical Trials as Topic; Cytarabine; DNA; Dose-Response Relationship, Drug; Drug Resistance; Half-Life; Humans; Interphase; Leukemia; Leukemia L5178; Time Factors | 1985 |
Pharmacokinetics of Ara-CMP-Stearate (YNK01): phase I study of the oral Ara-C derivative.
Topics: Administration, Oral; Antineoplastic Agents; Arabinofuranosyluracil; Arabinonucleotides; Cytarabine; Cytidine Monophosphate; Dose-Response Relationship, Drug; Half-Life; Humans; Leukemia, Myeloid, Acute; Lymphoma, Non-Hodgkin; Statistics, Nonparametric | 1995 |
Clinical pharmacology of intermediate and low-dose cytosine arabinoside (ara-C) therapy in patients with hematologic malignancies.
Topics: Aged; Aged, 80 and over; Antimetabolites, Antineoplastic; Arabinofuranosyluracil; Cytarabine; Dose-Response Relationship, Drug; Female; Hematologic Neoplasms; Humans; Male; Metabolic Clearance Rate; Middle Aged | 1998 |
101 other study(ies) available for cytarabine and arabinofuranosyluracil
| Article | Year |
|---|---|
Synthesis and antiviral activities of arabinofuranosyl-5-ethylpyrimidine nucleosides. Selective antiherpes activity of 1-(beta-D-arabinofuranosyl)-5-ethyluracil.
Topics: Antiviral Agents; Arabinofuranosyluracil; Circular Dichroism; Cytarabine; Cytopathogenic Effect, Viral; Deamination; Magnetic Resonance Spectroscopy; Simplexvirus; Uridine; Vaccinia virus; Vesicular stomatitis Indiana virus | 1979 |
Design, chemical synthesis and antiviral evaluation of 2'-deoxy-2'-fluoro-2'-C-methyl-4'-thionucleosides.
Topics: Antiviral Agents; Dose-Response Relationship, Drug; Drug Design; Hepacivirus; Microbial Sensitivity Tests; Molecular Structure; Structure-Activity Relationship; Thionucleosides; Virus Replication | 2022 |
A radioimmunoassay method for 1-beta-D-arabinofuranosyluracil using antibodies directed against 1-beta-D-arabinofuranosylcytosine.
Topics: Animals; Antibodies; Arabinofuranosyluracil; Chemical Phenomena; Chemistry; Cross Reactions; Cytarabine; Hydrogen-Ion Concentration; Mice; Nucleosides; Nucleotides; Pyrimidine Nucleosides; Radioimmunoassay | 1977 |
A radioimmunoassay for 1-beta-D-arabinofuranosyluracil with reference to cross-reactivity of 1-beta-D-arabinofuranosylcytosine with an antibody.
Topics: Antibodies; Antibody Specificity; Arabinofuranosyluracil; Binding Sites, Antibody; Cross Reactions; Cytarabine; Hydrogen-Ion Concentration; Pyrimidine Nucleosides; Radioimmunoassay | 1977 |
Extraction and analytic procedures for cytosine arabinoside and 1-beta-D-arabinofuranosyluracil and their 5'-mono-, di-, and tri-phosphates.
Topics: Animals; Arabinofuranosyluracil; Chromatography, High Pressure Liquid; Chromatography, Paper; Cytarabine; Cytosine Nucleotides; Methods; Mice; Perchlorates; Pyrimidine Nucleosides; Trichloroacetic Acid; Uracil Nucleotides | 1977 |
Pharmacologic studies of continuous infusion of arabinosylcytosine by liquid infusion system.
Topics: Arabinofuranosyluracil; Cytarabine; Humans; Infusions, Parenteral; Leukemia, Myeloid, Acute; Methods | 1977 |
Multiple determinants of antimetabolite action in humans.
Topics: Animals; Antimetabolites, Antineoplastic; Arabinofuranosylcytosine Triphosphate; Arabinofuranosyluracil; Cytarabine; Daunorubicin; Deamination; DNA; Doxorubicin; Drug Resistance; Humans; Leukemia, Myeloid, Acute; Neoplasms, Experimental | 1979 |
Methotrexate-induced changes in the levels of 1-beta-D-arabinofuranosylcytosine triphosphate in L1210 cells.
Topics: Animals; Arabinofuranosylcytosine Triphosphate; Arabinofuranosyluracil; Arabinonucleotides; Cytarabine; Deoxycytidine Kinase; Drug Therapy, Combination; Female; Leukemia L1210; Methotrexate; Mice; Mice, Inbred Strains; Time Factors | 1979 |
Nucleosides. 107. Synthesis of 5-(beta-D-arabinofuranosyl)isocytosine and related C-nucleosides.
Topics: Animals; Arabinofuranosyluracil; Cells, Cultured; Cytarabine; Isomerism; Leukemia L1210; Methods | 1978 |
A radioimmunoassay for cytosine arabinoside.
Topics: Animals; Arabinofuranosylcytosine Triphosphate; Arabinofuranosyluracil; Cross Reactions; Cytarabine; Humans; Immune Sera; Ovalbumin; Radioimmunoassay; Sheep | 1979 |
Inhibition of microorganisms by pyrimidine nucleosides.
Topics: Arabinofuranosyluracil; Cell Survival; Cytarabine; Drug Resistance, Microbial; Enterococcus faecalis; Methotrexate; Pyrimidine Nucleosides; Species Specificity; Structure-Activity Relationship | 1975 |
Separation of 5'-mono-, di- and triphosphates of 1-beta-D-arabinofuranosylcytosine and of 1-beta-D-arabinofuranosyluracil by thin-layer and high pressure liquid chromatography.
Topics: Arabinofuranosyluracil; Chromatography, High Pressure Liquid; Chromatography, Thin Layer; Cytarabine; Cytosine Nucleotides; Pyrimidine Nucleosides; Time Factors; Uracil Nucleotides | 1976 |
Proton magnetic resonance studies of the effects of sugar hydroxyl dissociation on nucleoside conformation. Arabinosyl nucleosides with an intramolecular hydrogen bond between the pentose O(5') and O(2').
Topics: Arabinofuranosyluracil; Cytarabine; Magnetic Resonance Spectroscopy; Molecular Conformation; Pyrimidine Nucleosides; Structure-Activity Relationship | 1976 |
Inhibition of RNA polymerase as a possible anti-leukaemic action of cytosine arabinoside.
Topics: Arabinofuranosyluracil; Cell-Free System; Cells, Cultured; Cytarabine; DNA-Directed RNA Polymerases; Kinetics; Leukemia; Structure-Activity Relationship | 1976 |
In vitro drug combination of 1-beta-D-arabinofuranosyl-E-5-(2-bromovinyl)uracil with anti-human immunodeficiency virus or anticancer nucleosides.
Topics: Antiviral Agents; Arabinofuranosyluracil; Bromouracil; Cytarabine; Drug Combinations; Floxuridine; Fluorouracil; Herpesvirus 3, Human; HIV-1; Humans; Zidovudine | 1992 |
Differences in the intracellular pharmacokinetics of cytosine arabinoside (AraC) between circulating leukemic blasts and normal mononuclear blood cells.
Topics: Acute Disease; Antineoplastic Combined Chemotherapy Protocols; Arabinofuranosylcytosine Triphosphate; Arabinofuranosyluracil; Cytarabine; Daunorubicin; Drug Administration Schedule; Humans; Leukemia, Myeloid; Leukocytes, Mononuclear; Lymphoma, Non-Hodgkin; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Thioguanine | 1992 |
Deoxypyrimidine-induced inhibition of the cytokinetic effects of 1-beta-D-arabinofuranosyluracil.
Topics: Animals; Arabinofuranosyluracil; Cell Cycle; Cytarabine; Deoxycytidine Kinase; DNA, Neoplasm; Dose-Response Relationship, Drug; Drug Synergism; Flow Cytometry; Leukemia L1210; Mice; Nucleosides; Pyrimidines; S Phase; Thymidine Kinase | 1992 |
Phenotypic analysis of 1-B-D-arabinofuranosylcytosine deamination in patients treated with high doses and correlation with response.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Arabinofuranosyluracil; Cytarabine; Deamination; Dose-Response Relationship, Drug; Female; Humans; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Leukemia, Myeloid, Acute; Leukocyte Count; Male; Middle Aged; Phenotype; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Serum Albumin, Bovine; Sex Factors | 1992 |
Correspondence Re: L.E. Damon et al., Plasma and cerebrospinal fluid pharmacokinetics of 1-beta-D-arabinofuranosylcytosine and 1-beta-D-arabinofuranosyluracil following the repeated intravenous administration of high- and intermediate-dose 1-beta-D-arabin
Topics: Arabinofuranosyluracil; Cytarabine; Cytidine Deaminase; Humans | 1992 |
Effects of 2'-fluorinated arabinosyl-pyrimidine nucleosides on duck hepatitis B virus DNA level in serum and liver of chronically infected ducks.
Topics: Animals; Antiviral Agents; Arabinofuranosyluracil; Cytarabine; DNA, Viral; Drug Evaluation, Preclinical; Ducks; Hepatitis B Virus, Duck; Hepatitis, Viral, Animal; Liver; Virus Replication | 1992 |
Pharmacokinetics of ara-C and ara-U in plasma and CSF after high-dose administration of cytosine arabinoside.
Topics: Arabinofuranosyluracil; Central Nervous System Neoplasms; Combined Modality Therapy; Cytarabine; Female; Half-Life; Humans; Lymphoma; Male; Metabolic Clearance Rate; Middle Aged | 1992 |
Plasma and cerebrospinal fluid pharmacokinetics of 1-beta-D-arabinofuranosylcytosine and 1-beta-D-arabinofuranosyluracil following the repeated intravenous administration of high- and intermediate-dose 1-beta-D-arabinofuranosylcytosine.
Topics: Adult; Arabinofuranosyluracil; Cytarabine; Dose-Response Relationship, Drug; Female; Humans; Leukemia, Myeloid, Acute; Male; Middle Aged; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Regression Analysis | 1991 |
Equine herpes virus 1 and pseudorabies virus resistance to 2'-fluoropyrimidine analogs and to bromovinyldeoxyuridine: implications for dTMP kinase activity.
Topics: Animals; Antiviral Agents; Arabinofuranosyluracil; Bromodeoxyuridine; Cytarabine; Drug Resistance, Microbial; Herpesviridae; Herpesvirus 1, Suid; Horses; Nucleoside-Phosphate Kinase; Pseudorabies; Pyrimidine Nucleosides; Substrate Specificity | 1990 |
Extremely prolonged continuous intraperitoneal infusion of cytosine arabinoside.
Topics: Adult; Aged; Arabinofuranosyluracil; Ascitic Fluid; Colonic Neoplasms; Cytarabine; Female; Humans; Infusion Pumps, Implantable; Infusions, Parenteral; Leukopenia; Metabolic Clearance Rate; Middle Aged; Ovarian Neoplasms; Peritonitis; Thrombocytopenia; Time Factors | 1990 |
The disposition of cytosine arabinoside and its metabolite after single doses to rabbits.
Topics: Animals; Arabinofuranosyluracil; Cytarabine; Dose-Response Relationship, Drug; Drug Administration Schedule; Injections, Intravenous; Male; Rabbits | 1990 |
Inhibitory effects of 2'-fluorinated arabinosyl-pyrimidine nucleosides on woodchuck hepatitis virus replication in chronically infected woodchucks.
Topics: Administration, Oral; Animals; Antiviral Agents; Arabinofuranosyluracil; Chronic Disease; Cytarabine; Hepadnaviridae; Hepatitis, Viral, Animal; Uridine; Virus Replication | 1990 |
[Intraperitoneal (i.p.) chemotherapy in the management of ovarian cancer--pharmacokinetics and methods of sequential i.p. chemotherapy].
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Arabinofuranosyluracil; Carcinoma, Squamous Cell; Child; Cisplatin; Cystadenocarcinoma; Cytarabine; Drug Administration Schedule; Etoposide; Female; Follow-Up Studies; Humans; Infusion Pumps; Infusions, Parenteral; Middle Aged; Ovarian Neoplasms; Teratoma | 1990 |
High-performance liquid chromatographic assay for cytosine arabinoside and uracil arabinoside in cerebrospinal fluid and plasma.
Topics: Arabinofuranosyluracil; Chromatography, High Pressure Liquid; Cytarabine; Humans; Leukemia; Spectrophotometry, Ultraviolet; Uridine | 1989 |
Development of resistance to 1-beta-D-arabinofuranosylcytosine after high-dose treatment in childhood lymphoblastic leukemia: analysis of resistance mechanism in established cell lines.
Topics: Arabinofuranosylcytosine Triphosphate; Arabinofuranosyluracil; Child; Cytarabine; Drug Resistance; Humans; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Time Factors; Tumor Cells, Cultured | 1989 |
Modulation of the metabolism and pharmacokinetics of 1-beta-D-arabinofuranosylcytosine by 1-beta-D-arabinofuranosyluracil in leukemic mice.
Topics: Animals; Arabinofuranosyluracil; Cytarabine; Cytidine Deaminase; Kidney; Kinetics; Leukemia L5178; Leukemia, Experimental; Liver; Male; Mice; Mice, Inbred Strains; Uridine | 1989 |
Liquid-chromatographic monitoring of cytosine arabinoside and its metabolite, uracil arabinoside, in serum.
Topics: Aged; Arabinofuranosyluracil; Chromatography, High Pressure Liquid; Cytarabine; Female; Humans; Leukemia, Myeloid, Acute; Male; Spectrophotometry, Ultraviolet; Uridine | 1989 |
Clinical pharmacology of N4-palmitoyl-1-beta-D-arabinofuranosylcytosine in patients with hematologic malignancies.
Topics: Adult; Aged; Antineoplastic Agents; Arabinofuranosyluracil; Cytarabine; Female; Hematologic Diseases; Humans; Leukemia; Male; Middle Aged; Polycythemia Vera | 1989 |
Determination of 3H-labelled cytosine arabinoside and eight metabolites in cell extracts by high-performance liquid chromatography and scintillation spectrometry.
Topics: Arabinofuranosyluracil; Cell Line; Chromatography, High Pressure Liquid; Cytarabine; Humans; Hydrogen-Ion Concentration; Leukemia; Scintillation Counting; Spectrophotometry, Ultraviolet; Tumor Cells, Cultured | 1989 |
Enhanced serum concentrations of Ara-C using suppositories containing tetrahydrouridine as a deamination inhibitor of Ara-C.
Topics: Animals; Arabinofuranosyluracil; Biological Availability; Cytarabine; Deamination; Dogs; Kinetics; Salicylates; Salicylic Acid; Suppositories; Tetrahydrouridine; Uridine | 1986 |
Comparative anti-herpesvirus activities of 9-(1,3-dihydroxy-2-propoxymethyl)guanine, acyclovir, and two 2'-fluoropyrimidine nucleosides.
Topics: Acyclovir; Animals; Antiviral Agents; Arabinofuranosyluracil; Brain Diseases; Cell Line; Chlorocebus aethiops; Cytarabine; Encephalitis; Female; Ganciclovir; Guinea Pigs; Herpes Genitalis; Herpes Simplex; Kidney; Mice; Simplexvirus; Structure-Activity Relationship | 1985 |
Human cytomegalovirus-induced DNA polymerase and its interaction with the triphosphates of 1-(2'-deoxy-2'-fluoro-beta-D-arabinofuranosyl)-5-methyluracil, -5-iodocytosine, and -5-methylcytosine.
Topics: Antiviral Agents; Arabinofuranosylcytosine Triphosphate; Arabinofuranosyluracil; Arabinonucleotides; Cytarabine; Cytomegalovirus; DNA Replication; DNA-Directed DNA Polymerase; Enzyme Induction; Humans; Kinetics; Nucleic Acid Synthesis Inhibitors; Substrate Specificity; Virus Replication | 1985 |
Drug resistance patterns of herpes simplex virus isolates from patients treated with acyclovir.
Topics: Acyclovir; Adult; Animals; Antiviral Agents; Arabinofuranosyluracil; Bromodeoxyuridine; Cytarabine; Drug Resistance, Microbial; Female; Ganciclovir; Humans; Male; Mice; Mice, Inbred BALB C; Simplexvirus; Stomatitis, Herpetic; Thymidine Kinase; Virulence | 1985 |
Susceptibility of varicella-zoster virus to thymidine analogues.
Topics: Acyclovir; Antiviral Agents; Arabinofuranosyluracil; Cytarabine; Deoxyuridine; Fibroblasts; Herpesvirus 3, Human; Humans; Neutralization Tests; Simplexvirus; Thymidine | 1986 |
Comparative efficacy of three 2'-fluoropyrimidine nucleosides and 9-(1,3-dihydroxy-2-propoxymethyl)guanine (BW B759U) against pseudorabies and equine rhinopneumonitis virus infection in vitro and in laboratory animals.
Topics: Acyclovir; Animals; Antiviral Agents; Arabinofuranosyluracil; Cricetinae; Cytarabine; Ganciclovir; Herpesviridae Infections; Herpesvirus 1, Equid; Herpesvirus 1, Suid; Male; Mice; Pseudorabies; Pyrimidine Nucleosides | 1987 |
Nucleosides. 139. Synthesis and anticytomegalovirus and antiherpes simplex virus activity of 5'-modified analogues of 2'-fluoroarabinosylpyrimidine nucleosides.
Topics: Animals; Antiviral Agents; Arabinofuranosyluracil; Cytarabine; Cytomegalovirus; Drug Evaluation, Preclinical; Fluorine; Indicators and Reagents; Magnetic Resonance Spectroscopy; Simplexvirus; Structure-Activity Relationship; Uridine; Vero Cells | 1987 |
A mammalian cell line designed to test the mutagenic activity of anti-herpes nucleosides.
Topics: Acyclovir; Animals; Antiviral Agents; Arabinofuranosyluracil; Cell Division; Cell Line; Cricetinae; Cricetulus; Cytarabine; DNA, Viral; Idoxuridine; Mutagenicity Tests; Nucleosides; Simplexvirus; Thymidine Kinase; Transfection; Trifluridine | 1987 |
Does the metabolite uracil arabinoside inhibit cytosine arabinoside (Ara-C) penetration into the cerebrospinal fluid during high-dose Ara-C therapy?
Topics: Adult; Arabinofuranosyluracil; Biological Transport; Blood-Brain Barrier; Cytarabine; Half-Life; Humans; Kinetics; Leukemia, Myeloid, Acute; Male; Uridine | 1986 |
Pharmacologic studies of low-dose and high-dose continuous infusion cytosine arabinoside.
Topics: Adult; Aged; Arabinofuranosylcytosine Triphosphate; Arabinofuranosyluracil; Cytarabine; DNA Replication; Dose-Response Relationship, Drug; Female; Humans; Infusions, Intravenous; Leukemia, Myeloid, Acute; Male; Middle Aged; Replicon; Thrombocytopenia | 1987 |
Pharmacokinetic study of cytosine arabinoside in patients with acute myelogeneous leukemia.
Topics: Antineoplastic Combined Chemotherapy Protocols; Arabinofuranosyluracil; Cytarabine; Daunorubicin; Humans; Kinetics; Leukemia, Myeloid, Acute; Mitoxantrone; Thioguanine | 1987 |
[Radiosensitization effects of nucleoside analogs].
Topics: Acyclovir; Animals; Antineoplastic Agents; Arabinofuranosyluracil; Cytarabine; Mammary Neoplasms, Experimental; Mice; Mice, Inbred C3H; Nucleosides; Radiation-Sensitizing Agents; Vidarabine; Whole-Body Irradiation | 1986 |
Pharmacokinetic parameters of 1-beta-D-arabinofuranosylcytosine (ara-C) and their relationship to intracellular metabolism of ara-C, toxicity, and response of patients with acute nonlymphocytic leukemia treated with conventional and high-dose ara-C.
Topics: Acute Disease; Animals; Arabinofuranosylcytosine Triphosphate; Arabinofuranosyluracil; Cytarabine; Drug Administration Schedule; Humans; Leukemia; Leukemia L1210; Metabolic Clearance Rate; Mice; Uridine Kinase | 1987 |
Pharmacology of combination chemotherapy of cytosine arabinoside (ara-C) and uracil arabinoside (ara-U) or tetrahydrouridine (THU) against murine leukemia L1210/0 in tumor-bearing mice.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Arabinofuranosyluracil; Cytarabine; Deamination; Leukemia L1210; Male; Mice; Tetrahydrouridine; Time Factors; Uridine | 1987 |
Quantitative determination of antiviral nucleoside analog in DNA.
Topics: Animals; Antiviral Agents; Arabinofuranosyluracil; Cells, Cultured; Chlorocebus aethiops; Chromatography, High Pressure Liquid; Cytarabine; DNA, Viral; Herpesviridae; Hydrolysis; Nucleosides | 1986 |
Role of thymidylate synthetase in the cytostatic activity of pyrimidine nucleoside analogues.
Topics: Animals; Antineoplastic Agents; Arabinofuranosyluracil; Cytarabine; Deoxycytidine; Deoxyuridine; Leukemia L1210; Mice; Pyrimidine Nucleosides; Thymidylate Synthase | 1985 |
In vivo studies on high-dose 1-beta-D-arabinofuranosylcytosine (HDara-C) and 1-beta-D-arabinofuranosyluracil (ara-U) with respect to pharmacokinetics, cell kinetics, and cytotoxicity in a rat myelocytic leukemia model (BNML).
Topics: Animals; Arabinofuranosyluracil; Cell Cycle; Colony-Forming Units Assay; Cytarabine; Cytidine Deaminase; Disease Models, Animal; Half-Life; Humans; Kinetics; Leukemia, Myeloid, Acute; Nucleoside Deaminases; Rats; Uridine | 1985 |
Kinetics and substrate specificity of human and canine cytidine deaminase.
Topics: Animals; Arabinofuranosyluracil; Cytarabine; Cytidine; Cytidine Deaminase; Deoxycytidine; Dogs; Humans; Kinetics; Liver; Nucleoside Deaminases; Substrate Specificity | 1986 |
Effect of uracil arabinoside on metabolism and cytotoxicity of cytosine arabinoside in L5178Y murine leukemia.
Topics: Animals; Arabinofuranosyluracil; Cytarabine; Cytotoxicity, Immunologic; Drug Interactions; Humans; Kinetics; Leukemia L5178; Leukemia, Experimental; Tumor Stem Cell Assay; Uridine | 1985 |
Cell-specific antiviral activity of 1-(2-fluoro-2-deoxy-beta-D-arabinofuranosyl)-5-iodocytosine (FIAC) against Marek's disease herpesvirus and turkey herpesvirus.
Topics: Animals; Antineoplastic Agents; Antiviral Agents; Arabinofuranosyluracil; Cells, Cultured; Cytarabine; Cytidine Deaminase; Herpesviridae Infections; Herpesvirus 2, Gallid; Marek Disease; Nucleoside Deaminases; Thymidine Kinase; Turkeys; Virus Replication | 1984 |
Acute cerebellar toxicity after high-dose cytarabine associated with CNS accumulation of its metabolite, uracil arabinoside.
Topics: Arabinofuranosyluracil; Carcinoma, Small Cell; Cerebellar Diseases; Cytarabine; Humans; Lung Neoplasms; Male; Middle Aged; Uridine | 1984 |
Kinetics of deamination of 5-aza-2'-deoxycytidine and cytosine arabinoside by human liver cytidine deaminase and its inhibition by 3-deazauridine, thymidine or uracil arabinoside.
Topics: 3-Deazauridine; Adult; Arabinofuranosyluracil; Azacitidine; Cytarabine; Cytidine Deaminase; Cytosine; Decitabine; Humans; Kinetics; Liver; Nucleoside Deaminases; Substrate Specificity; Thymidine | 1983 |
Effect of eight antiviral drugs on the reactivation of herpes simplex virus in explant cultures of latently infected mouse trigeminal ganglia.
Topics: Acyclovir; Animals; Antibodies, Viral; Antiviral Agents; Arabinofuranosyluracil; Arabinonucleosides; Bromodeoxyuridine; Culture Media; Culture Techniques; Cytarabine; Foscarnet; Mice; Mice, Hairless; Neutralization Tests; Phosphonoacetic Acid; Simplexvirus; Thymidine; Trigeminal Nerve; Vidarabine Phosphate; Virus Activation | 1984 |
Treatment of primary acute genital herpes in guinea pigs by intraperitoneal administration of fluoropyrimidines.
Topics: Acyclovir; Animals; Antiviral Agents; Arabinofuranosyluracil; Cytarabine; Female; Foscarnet; Guinea Pigs; Herpes Genitalis; Injections, Intraperitoneal; Male; Phosphonoacetic Acid; Uridine; Virus Replication | 1984 |
Distribution, metabolism, and excretion of 1-(2-fluoro-2-deoxy-beta-D- arabinofuranosyl)thymine and 1-(2-fluoro-2-deoxy-beta-D-arabinofuranosyl)-5- iodocytosine.
Topics: Absorption; Animals; Arabinofuranosyluracil; Chromatography, High Pressure Liquid; Cytarabine; Digestive System; Dogs; Female; Kidney; Male; Metabolic Clearance Rate; Mice; Rats; Simplexvirus; Species Specificity; Tissue Distribution; Uridine; Virus Replication | 1983 |
Epstein-Barr virus: inhibition of replication by three new drugs.
Topics: Acyclovir; Antiviral Agents; Arabinofuranosyluracil; Bromodeoxyuridine; Cytarabine; DNA Replication; Herpesvirus 4, Human; Uridine; Virus Replication | 1983 |
Sensitive radioimmunoassay for cytarabine and uracil arabinoside in plasma.
Topics: Animals; Antibody Specificity; Arabinofuranosyluracil; Cross Reactions; Cytarabine; Haptens; Metabolic Clearance Rate; Mice; Radioimmunoassay; Uridine | 1984 |
High-performance liquid chromatographic assay for cytosine arabinoside, uracil arabinoside and some related nucleosides.
Topics: Arabinofuranosyluracil; Child; Chromatography, High Pressure Liquid; Cytarabine; Cytidine; Deoxycytidine; Humans; Infusions, Parenteral; Kinetics; Leukemia, Myeloid, Acute; Uridine | 1983 |
Cytosine arabinoside cerebrospinal fluid kinetics.
Topics: Adolescent; Arabinofuranosyluracil; Child; Cytarabine; Female; Humans; Injections, Intraventricular; Kinetics; Leukemia, Lymphoid; Male; Meningeal Neoplasms; Metabolic Clearance Rate | 1984 |
Cerebrospinal fluid and plasma pharmacokinetics of high doses of 1-beta-D-arabinofuranosylcytosine in nonhuman primates.
Topics: Animals; Arabinofuranosyluracil; Chromatography, High Pressure Liquid; Cytarabine; Dose-Response Relationship, Drug; Kinetics; Macaca mulatta; Papio | 1983 |
Therapeutic activities of 1-(2-fluoro-2-deoxy-beta-D-arabinofuranosyl)-5-iodocytosine and -thymine alone and in combination with acyclovir and vidarabine in mice infected intracerebrally with herpes simplex virus.
Topics: Acyclovir; Administration, Oral; Animals; Antiviral Agents; Arabinofuranosyluracil; Brain; Cytarabine; Drug Therapy, Combination; Encephalitis; Female; Herpes Simplex; Injections, Intraperitoneal; Mice; Uridine; Vidarabine | 1983 |
Simultaneous analysis of 1-beta-D-arabinofuranosylcytosine, 1-beta-D-arabinofuranosyluracil and sodium salicylate in biological samples by high-performance liquid chromatography.
Topics: Animals; Arabinofuranosyluracil; Chromatography, High Pressure Liquid; Cytarabine; Dogs; Sodium Salicylate; Suppositories; Time Factors; Uridine | 1983 |
Alteration of the pharmacokinetics of high-dose ara-C by its metabolite, high ara-U in patients with acute leukemia.
Topics: Acute Disease; Arabinofuranosyluracil; Chromatography, High Pressure Liquid; Cytarabine; Cytidine Deaminase; Dose-Response Relationship, Drug; Humans; Infusions, Parenteral; Kinetics; Leukemia; Models, Biological; Nucleoside Deaminases; Radioimmunoassay; Time Factors; Uridine | 1983 |
Comparison of 2'-fluoro-arabinosyl pyrimidine nucleosides and 1-beta-D-arabinofuranosylcytosine on immunological parameters in vitro.
Topics: Animals; Antibody Formation; Antibody-Producing Cells; Arabinofuranosyluracil; Cell Survival; Cytarabine; Immune Tolerance; Mice; Spleen; Uridine | 1983 |
Intraperitoneal cytosine arabinoside therapy in ovarian carcinoma.
Topics: Adult; Aged; Arabinofuranosyluracil; Cytarabine; Female; Humans; Injections, Intraperitoneal; Kinetics; Middle Aged; Ovarian Neoplasms; Peritoneal Dialysis; Tumor Stem Cell Assay | 1984 |
Pharmacokinetics of N4-behenoyl-1-beta-D-arabinofuranosylcytosine in patients with acute leukemia.
Topics: Acute Disease; Adult; Antineoplastic Agents; Arabinofuranosyluracil; Bone Marrow; Child; Child, Preschool; Chromatography, High Pressure Liquid; Cytarabine; Erythrocytes; Gas Chromatography-Mass Spectrometry; Humans; Infant; Infusions, Parenteral; Kinetics; Leukemia; Middle Aged; Time Factors | 1983 |
Cytosine arabinoside deamination in human leukaemic myeloblasts and resistance to cytosine arabinoside therapy.
Topics: Adult; Arabinofuranosylcytosine Triphosphate; Arabinofuranosyluracil; Bone Marrow; Cells, Cultured; Cytarabine; Deamination; DNA, Neoplasm; Dose-Response Relationship, Drug; Drug Resistance; Humans; Leukemia, Myeloid, Acute; Tetrahydrouridine | 1981 |
The relationship of Ara-C metabolism in vitro to therapeutic response in acute myeloid leukaemia.
Topics: Arabinofuranosyluracil; Bone Marrow Cells; Cytarabine; Cytidine Triphosphate; Deamination; Humans; Leukemia, Myeloid, Acute; Phosphorylation; Time Factors | 1982 |
Potent antiviral 2'-fluoro-arabinosyl pyrimidine nucleosides: lack of mutagenic activity.
Topics: Animals; Antiviral Agents; Arabinofuranosyluracil; Cell Line; Cricetinae; Cricetulus; Cytarabine; DNA; Liver; Mutagenicity Tests; Rats; Rats, Inbred Strains; Salmonella typhimurium; Uridine | 1982 |
Activity of 2-fluoro-5-methylarabinofuranosyluracil against mouse leukemias sensitive to and resistant to 1-beta-D-arabinofuranosylcytosine.
Topics: Animals; Arabinofuranosyluracil; Cells, Cultured; Cytarabine; Humans; Leukemia L1210; Leukemia P388; Leukemia, Experimental; Mice; Pyrimidine Nucleosides | 1982 |
[The simultaneous determination of Ara-U and Ara-C, urinary metabolites of N4-behenoyl-1-beta-D-arabinofuranosylcytosine by mass fragmentography (author's transl)].
Topics: Antineoplastic Agents; Arabinofuranosyluracil; Cytarabine; Gas Chromatography-Mass Spectrometry; Humans; Uridine | 1982 |
Clinical results and pharmacokinetics of high-dose cytosine arabinoside (HD ARA-C).
Topics: Adult; Arabinofuranosyluracil; Cytarabine; Drug Administration Schedule; Female; Gastrointestinal Diseases; Half-Life; Humans; Kinetics; Leukemia; Male; Metabolic Clearance Rate; Middle Aged; Teratoma; Time Factors | 1982 |
Biochemical effects of 2'-fluoro-5-methyl-1-beta-D-arabinofuranosyluracil and 2'-fluoro-5-iodo-1-beta-D-arabinofuranosylcytosine in mouse leukemic cells sensitive and resistant to 1-beta-D-arabinofuranosylcytosine.
Topics: Animals; Arabinofuranosyluracil; Cell Survival; Cytarabine; Deoxycytidine; DNA Replication; Kinetics; Leukemia L1210; Leukemia, Experimental; Mice; Thymidine; Uridine | 1982 |
Quantitative autoradiographic mapping of herpes simplex virus encephalitis with a radiolabeled antiviral drug.
Topics: Animals; Antiviral Agents; Arabinofuranosyluracil; Autoradiography; Cytarabine; Encephalitis; Herpes Simplex; Rats; Uridine | 1982 |
Determination of 1-beta-D-arabinofuranosylcytosine and 1-beta-D-arabinofuranosyluracil in human plasma by high-performance liquid chromatography.
Topics: Arabinofuranosyluracil; Chromatography, High Pressure Liquid; Cytarabine; Humans; Leukemia; Uridine | 1981 |
Determination of cytarabine and uracil arabinoside in human plasma and cerebrospinal fluid by high-performance liquid chromatography.
Topics: Arabinofuranosyluracil; Chromatography, High Pressure Liquid; Cytarabine; Humans; Leukemia; Time Factors; Uridine | 1981 |
High-performance liquid chromatographic analysis of cytosine arabinoside and metabolites in biological samples.
Topics: Animals; Arabinofuranosylcytosine Triphosphate; Arabinofuranosyluracil; Chromatography, High Pressure Liquid; Cytarabine; Female; Mice; Neoplasms, Experimental | 1980 |
Ion-pair liquid chromatography of cytarabine and uracil-arabinoside in human plasma.
Topics: Adult; Arabinofuranosyluracil; Chromatography, High Pressure Liquid; Chromatography, Liquid; Cytarabine; Half-Life; Humans; Infusions, Intravenous; Quality Control; Spectrophotometry, Ultraviolet | 1995 |
Plasma and leukemic cell pharmacokinetics of high-dose N4-behenoyl-1-beta-D-arabinofuranosylcytosine in acute leukemia patients.
Topics: Antineoplastic Agents; Arabinofuranosyluracil; Chromatography, High Pressure Liquid; Cytarabine; Half-Life; Humans; Infusions, Intravenous; Leukemia, Myeloid, Acute; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 1994 |
Chemotherapy with cytosine arabinoside in a child with Burkitt's lymphoma on maintenance hemodialysis and hemofiltration.
Topics: Arabinofuranosyluracil; Burkitt Lymphoma; Child; Cytarabine; Hemofiltration; Humans; Infusions, Intravenous; Kidney Failure, Chronic; Male; Renal Dialysis; Ultraviolet Rays | 1993 |
Severe toxicity of fialuridine (FIAU)
Topics: Antiviral Agents; Arabinofuranosyluracil; Chronic Disease; Cytarabine; Drug Approval; Hepatitis B; Humans | 1996 |
Optimizing therapy for acute myeloid leukemia based on differences in intracellular metabolism of cytosine arabinoside between leukemic blasts and normal mononuclear blood cells.
Topics: Acute Disease; Antimetabolites, Antineoplastic; Arabinofuranosylcytosine Triphosphate; Arabinofuranosyluracil; Cytarabine; Female; Humans; Leukemia, Myeloid; Leukocytes, Mononuclear; Male | 1996 |
NONMEM population pharmacokinetic studies of cytosine arabinoside after high-dose and after loading bolus followed by continuous infusion of the drug in pediatric patients with leukemias.
Topics: Adolescent; Adult; Arabinofuranosyluracil; Child; Child, Preschool; Chromatography, High Pressure Liquid; Cytarabine; Half-Life; Humans; Infant; Infusions, Intravenous; Leukemia; Metabolic Clearance Rate; Models, Biological | 1996 |
Pharmacokinetics of high-dose cytarabine and its deamination product--a reappraisal.
Topics: Acute Disease; Adult; Aged; Antimetabolites, Antineoplastic; Arabinofuranosyluracil; Cytarabine; Deamination; Dose-Response Relationship, Drug; Female; Humans; Leukemia; Male; Middle Aged; Myelodysplastic Syndromes | 1997 |
5'-Phosphoramidates and 5'-diphosphates of 2'-O-allyl-beta-D-arabinofuranosyluracil, -cytosine, and -adenine: inhibition of ribonucleotide reductase.
Topics: Animals; Antineoplastic Agents; Arabinofuranosyluracil; Cytarabine; Deoxycytidine Kinase; Drug Screening Assays, Antitumor; Humans; Mice; Models, Molecular; Phosphorylation; Prodrugs; Recombinant Proteins; Ribonucleotide Reductases; Structure-Activity Relationship; Thymidine Kinase; Tumor Cells, Cultured; Vidarabine | 1999 |
Micellar electrokinetic capillary chromatography quantification of cytosine arabinoside and its metabolite, uracil arabinoside, in human serum.
Topics: Antimetabolites, Antineoplastic; Arabinofuranosyluracil; Chromatography, Micellar Electrokinetic Capillary; Cytarabine; Humans; Leukemia, Myeloid; Osmolar Concentration; Reproducibility of Results; Sensitivity and Specificity; Temperature | 2001 |
GATA1, cytidine deaminase, and the high cure rate of Down syndrome children with acute megakaryocytic leukemia.
Topics: Antimetabolites, Antineoplastic; Arabinofuranosylcytosine Triphosphate; Arabinofuranosyluracil; Blotting, Western; Child; Cytarabine; Cytidine Deaminase; DNA-Binding Proteins; Down Syndrome; Erythroid-Specific DNA-Binding Factors; GATA1 Transcription Factor; Humans; Leukemia, Megakaryoblastic, Acute; Polymerase Chain Reaction; Time Factors; Transcription Factors; Transcription, Genetic; Transcriptional Activation; Up-Regulation | 2005 |
AraU accumulation in patients with renal insufficiency as a potential mechanism for cytarabine neurotoxicity.
Topics: Aged; Antimetabolites, Antineoplastic; Arabinofuranosyluracil; Cytarabine; Female; Half-Life; Humans; Kidney Failure, Chronic; Leukemia, Myeloid, Acute; Male; Middle Aged; Neurotoxicity Syndromes | 2008 |
Effective clearance of Ara-U the major metabolite of cytosine arabinoside (Ara-C) by hemodialysis in a patient with lymphoma and end-stage renal failure.
Topics: Antimetabolites, Antineoplastic; Arabinofuranosyluracil; Chromatography, High Pressure Liquid; Cytarabine; Female; Humans; Kidney Failure, Chronic; Lymphoma, Mantle-Cell; Middle Aged; Neurotoxicity Syndromes; Renal Dialysis | 2011 |
Ecotoxicity and genotoxicity assessment of cytotoxic antineoplastic drugs and their metabolites.
Topics: Animals; Antineoplastic Agents; Arabinofuranosyluracil; beta-Alanine; Chlorophyta; Cytarabine; Daphnia; Deoxycytidine; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Fluorouracil; Gemcitabine; Growth Inhibitors; Mutagenicity Tests; Mutagens; Pseudomonas; Salmonella; Toxicity Tests | 2010 |
Evaluation of F-18-labeled 5-iodocytidine (18F-FIAC) as a new potential positron emission tomography probe for herpes simplex virus type 1 thymidine kinase imaging.
Topics: Animals; Arabinofuranosyluracil; Cell Line, Tumor; Cytarabine; Female; Fluorine Radioisotopes; Herpesvirus 1, Human; Mice; Positron-Emission Tomography; Sarcoma; Thymidine Kinase; Transfection | 2011 |
Long term cultured HL-60 cells are intrinsically resistant to Ara-C through high CDA activity.
Topics: Arabinofuranosylcytosine Triphosphate; Arabinofuranosyluracil; Cytarabine; Cytidine Deaminase; Drug Resistance, Neoplasm; HL-60 Cells; Humans; RNA, Messenger; RNA, Neoplasm | 2012 |
Enhancing the efficacy of Ara-C through conjugation with PAMAM dendrimer and linear PEG: a comparative study.
Topics: Arabinofuranosyluracil; Cell Line, Tumor; Chemical Phenomena; Chromatography, High Pressure Liquid; Cytarabine; Cytidine Deaminase; Dendrimers; Humans; Hydrogen-Ion Concentration; Leukemia, Myeloid, Acute; Magnetic Resonance Spectroscopy; Particle Size; Polyethylene Glycols; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization | 2013 |
Simultaneous determination of cytosine arabinoside and its metabolite, uracil arabinoside, in human plasma using hydrophilic interaction liquid chromatography with UV detection.
Topics: Arabinofuranosyluracil; Chromatography, High Pressure Liquid; Cytarabine; Humans; Hydrophobic and Hydrophilic Interactions; Limit of Detection; Linear Models; Male; Middle Aged; Reproducibility of Results; Spectrophotometry, Ultraviolet | 2013 |
Simultaneous determination of 1-β-d-Arabinofuranosylcytosine and two metabolites, 1-β-d-Arabinofuranosyluracil and 1-β-d-Arabinofuranosylcytosine triphosphate in leukemic cell by HPLC-MS/MS and the application to cell pharmacokinetics.
Topics: Adult; Antimetabolites, Antineoplastic; Arabinofuranosylcytosine Triphosphate; Arabinofuranosyluracil; Cell Line, Tumor; Chromatography, High Pressure Liquid; Cytarabine; Humans; Limit of Detection; Middle Aged; Tandem Mass Spectrometry; Young Adult | 2014 |
Spectrum of activity and mechanisms of resistance of various nucleoside derivatives against gammaherpesviruses.
Topics: Acyclovir; Amino Acid Sequence; Animals; Antiviral Agents; Arabinofuranosyluracil; Bromodeoxyuridine; Cytarabine; DNA-Directed DNA Polymerase; Drug Resistance, Viral; Foscarnet; Ganciclovir; Guanine; Herpesvirus 4, Human; Herpesvirus 8, Human; Humans; Molecular Sequence Data; Protein Kinases; Rhadinovirus; Sequence Alignment; Structure-Activity Relationship; Thymidine Kinase; Viral Proteins | 2014 |
HPLC-MS/MS method for the simultaneous determination of MB07133 and its metabolites, cytarabine and arabinofuranosyluracil, in rat plasma.
Topics: Animals; Arabinofuranosyluracil; Chromatography, High Pressure Liquid; Cytarabine; Male; Rats; Rats, Sprague-Dawley; Tandem Mass Spectrometry | 2016 |
Simultaneous determination of cytosine arabinoside and its metabolite uracil arabinoside in human plasma by LC-MS/MS: Application to pharmacokinetics-pharmacogenetics pilot study in AML patients.
Topics: Antimetabolites, Antineoplastic; Arabinofuranosyluracil; Chromatography, High Pressure Liquid; Cytarabine; Drug Monitoring; Humans; Leukemia, Myeloid, Acute; Linear Models; Pilot Projects; Reproducibility of Results; Sensitivity and Specificity; Tandem Mass Spectrometry | 2019 |