cytarabine has been researched along with arabinofuranosylcytosine triphosphate in 202 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 94 (46.53) | 18.7374 |
| 1990's | 73 (36.14) | 18.2507 |
| 2000's | 26 (12.87) | 29.6817 |
| 2010's | 6 (2.97) | 24.3611 |
| 2020's | 3 (1.49) | 2.80 |
| Authors | Studies |
|---|---|
| Dave, C; Mayhew, E; Papahadjopoulos, D; Rustum, YM | 1 |
| Preisler, HD; Rustum, YM | 2 |
| Rustum, YM | 1 |
| Cadman, E; Eiferman, F | 1 |
| Smyth, JF | 1 |
| Abe, I; Sato, H | 1 |
| Arai, Y; Inoue, I; Kondo, K; Nagura, T | 1 |
| Hilliard, S; Peck, C; Roberts, D; Wingo, W | 1 |
| Mattoccia, LP; Sorrentino, R | 1 |
| Aherne, GW; Marks, VM; Piall, EM | 1 |
| Büchner, T; Hiddemann, W; Kewer, U; Reuter, C; Rolf, C; Schleyer, E; Uhrmeister, C; Unterhalt, M; Wörmann, B; Zühlsdorf, M | 1 |
| Gandhi, V; Plunkett, W | 3 |
| Grant, S; Jarvis, WD; Pettit, GR; Turner, AJ; Wallace, HJ | 1 |
| Oh-hara, T; Tsukahara, S; Tsuruo, T; Yusa, K | 1 |
| Büchner, T; Busemann, C; Hiddemann, W; Kiehl, M; Schleyer, E; Wörmann, B; Zühlsdorf, M | 1 |
| Tanaka, M | 2 |
| Busch, FW; Ehninger, G; Hiddemann, W; Jaschonek, K; Proksch, B; Schleyer, E; Schmidt, H; Schuler, U; Wanner, T | 1 |
| Balázová, E; Benesová, M; Novotný, L; Reichelová, V; Scheithauer, W; Ujházy, V | 1 |
| Arlin, Z; Bhalla, K; Grant, S; Holladay, C; Ibrado, AM; Jasiok, M | 1 |
| Boise, L; Grant, S; Howe, C; McCrady, C; Pettit, GR; Turner, A; Westin, E | 1 |
| Higashigawa, M; Hori, H; Kawasaki, H; Kuwabara, H; Ohkubo, T; Sakurai, M | 1 |
| Higashigawa, M; Hori, H; Ido, M; Kawasaki, H; Kuwabara, H; Nagao, Y; Ohkubo, T; Sakurai, M | 1 |
| Bhalla, K; Grant, S; Swerdlow, P | 1 |
| David, JC; Marquet, J; Zittoun, J | 1 |
| Bhalla, K; Grant, S; McCrady, C | 1 |
| Hamazaki, M; Higashigawa, M; Hori, H; Ido, M; Kawasaki, H; Kuwabara, H; Ohkubo, T; Sakurai, M; Taniguchi, K | 1 |
| Bhandal, AK; Hill, HZ; Reddy, KB; Studzinski, GP | 1 |
| Estey, E; Heinemann, V; Keating, M; Plunkett, W | 1 |
| Kamiya, K; Nakamura, T; Uchida, M; Ueda, T | 1 |
| Chiba, P; Eher, R; Knapp, W; Köller, U; Kraupp, M; Salamon, J; Szekeres, T; Tihan, T | 1 |
| Heinemann, V; Jehn, U | 1 |
| Bouffard, DY; Momparler, LF; Momparler, RL; Onetto-Pothier, N | 1 |
| Aul, CH; Büchner, T; Heinecke, A; Hiddemann, W; Maschmeyer, G; Schleyer, E; Uhrmeister, C | 1 |
| Higashigawa, M; Hori, H; Kawasaki, H; Ohkubo, T; Sakurai, M; Yoshizumi, T | 1 |
| Estey, EH; Freireich, EJ; Keating, MJ; McCredie, KB; Plunkett, W | 1 |
| Békássy, AN; Garwicz, S; Gulliksson, H; Liliemark, J; Peterson, C; Wiebe, T | 1 |
| Capizzi, RL; Wang, LM; White, JC | 1 |
| Jamieson, GP; Snook, MB; Wiley, JS | 1 |
| Fridland, A; Verhoef, V | 1 |
| Akiyama, Y; Kubota, M; Mikawa, H; Takimoto, T; Tanizawa, A | 1 |
| Avramis, VI; Holcenberg, JS; Mecum, RA; Nyce, J; Steele, DA | 1 |
| Gandhi, V; Keating, MJ; Nowak, B; Plunkett, W | 1 |
| Tanaka, M; Yoshida, S | 2 |
| Akiyama, Y; Kiriyama, Y; Kito, T; Kubota, M; Mikawa, H; Takimoto, T; Tanizawa, A | 1 |
| Akiyama, Y; Kiriyama, Y; Kitoh, T; Kubota, M; Mikawa, H; Takimoto, T; Tanizawa, A | 1 |
| Higashigawa, M; Kamiya, H; Kawasaki, H; Ohkubo, T; Sakurai, M | 1 |
| Estey, E; Heinemann, V; Keating, MJ; Plunkett, W | 1 |
| Chan, TC | 1 |
| Aherne, GW; Dawson, VM; Ford, J; Kees, UR; Piall, E | 1 |
| David, JC; Maniey, D; Marquet, J; Zittoun, J; Zittoun, R | 1 |
| Mitchell, BS; Shewach, DS | 1 |
| Bertoncello, I; Bradley, TR; Jamieson, GP; Snook, MB; Wiley, JS | 1 |
| Hamazaki, M; Higashigawa, M; Ido, M; Kamiya, H; Kawasaki, H; Ohkubo, T; Sakurai, M; Taniguchi, K | 1 |
| Cheng, YC; Chiou, JF; Huang, ES; Mar, EC | 1 |
| Hirai, J; Itoh, K; Kanno, M; Kobayashi, K; Matsuda, TT; Nakamura, S; Ohtake, S; Yoshida, T | 1 |
| Joneckis, CC; Ross, DD; Song, TH; Wu, RK | 1 |
| Kufe, D; Matsukage, A; Ohno, T; Ohno, Y; Spriggs, D | 1 |
| Grindey, GB; Heinemann, V; Hertel, LW; Plunkett, W | 1 |
| Iacoboni, S; Keating, MJ; Plunkett, W | 1 |
| Burke, PJ; Dole, GB; Donehower, RC; Karp, JE | 1 |
| Adams, TM; Estey, E; Kantarjian, H; Keating, MJ; Liliemark, JO; Nowak, B; Plunkett, W | 1 |
| Finch, LR; Jamieson, GP; Snook, M; Wiley, JS | 1 |
| Griffin, JD; Kufe, DW; Spriggs, DR | 1 |
| Burke, PJ; Donehower, RC; Karp, JE | 1 |
| Estey, E; Freireich, EJ; Keating, MJ; McCredie, KB; Plunkett, W | 1 |
| Danhauser, L; Gandhi, V; Iacoboni, S; Keating, M; Liliemark, J; Plunkett, W | 1 |
| Avramis, VI; Biener, R; Ettinger, L; Finklestein, J; Holcenberg, JS; Krailo, M; Siegel, SE; Willoughby, M | 1 |
| Liliemark, JO; Plunkett, W | 1 |
| Campbell, J; Mayhew, E; Radel, S; Rustum, YM | 1 |
| Firkin, FC; Jamieson, GP; Sawyer, WH; Wiley, JS; Woodruff, RK | 1 |
| Keating, MJ; Nowak, B; Plunkett, W | 1 |
| Preisler, HD; Riva, C; Rustum, YM | 1 |
| Estey, E; Keating, MJ; Liliemark, JO; Plunkett, W | 1 |
| Gahrton, G; Liliemark, JO; Paul, CY; Peterson, CO | 1 |
| Akman, SA; Joneckis, CC; Ross, DD; Schiffer, CA; Thompson, BW | 2 |
| Grindey, GB; Plunkett, W | 1 |
| Keating, M; Plunkett, W | 1 |
| Azarnia, N; Preisler, HD; Priore, R; Rustum, YM | 1 |
| Preisler, HD; Riva, CM; Rustum, YM | 1 |
| Andersson, B; Beran, M; Estey, E; Freireich, EJ; Iacoboni, S; Kantarjian, H; Keating, MJ; McCredie, KB; Plunkett, W; Walters, R | 1 |
| Finch, LR; Jamieson, GP; Sawyer, WH; Snook, M; Taupin, J; Wiley, JS | 1 |
| Capizzi, RL; Cooper, MR; Jackson, DV; Muss, HB; Powell, BL; Richards, F; Spurr, CL; Stuart, JJ; White, DR; Zekan, PJ | 1 |
| Drenthe-Schonk, A; Haanen, C; Muus, P; Raymakers, R; Salden, M; Wessels, J | 1 |
| Edelstein, M; Valeriote, F | 1 |
| Kufe, DW; Spriggs, DR | 1 |
| Gahrton, CG; Liliemark, JO; Paul, CY; Peterson, CO | 1 |
| Danhauser, L; Estey, E; Iacoboni, S; Keating, MJ; Liliemark, JO; Plunkett, W | 1 |
| Browman, G; Preisler, HD; Raza, A; Rustum, Y | 1 |
| Preisler, HD; Priore, RL; Rustum, Y | 1 |
| Dixon, DO; Liliemark, JO; Plunkett, W | 1 |
| Hirota, H; Kamiya, H; Kawasaki, H; Komada, M; Nobori, T; Okubo, T; Sako, T; Sakurai, M; Shimizu, N | 1 |
| Malick, NC; Snyder, RD | 1 |
| Chekunova, EV; Gorbovitskaya, GE; Kulak, TI; Marennikova, SS; Matsevich, GR; Mikhailopulo, IA; Nikulina, VG | 1 |
| Arnold, W; Hess, G; Meyer zum Büschenfelde, KH | 1 |
| Cadman, E; Rauscher, F | 1 |
| Cadman, E; Grant, S | 1 |
| Alexanian, R; Barlogie, B; Dreicer, R; Kantarjian, H; Plunkett, W | 1 |
| Abe, I; Hori, K; Saito, S; Sato, H; Suzuki, M | 2 |
| Egan, EM; Kufe, D; Munroe, D; Spriggs, D | 1 |
| Bowman, WP; Danks, MK; Look, AT; Ochs, J; Rivera, G; Sinkule, JA | 1 |
| Howell, SB; Pfeifle, CE; Streifel, JA | 1 |
| Grahame-Smith, DG; Harris, AL | 1 |
| Chubb, S; Hug, V; Keating, MJ; Plunkett, W | 1 |
| Barlogie, B; Chubb, S; Plunkett, W | 1 |
| Bunch, C; Grahame-Smith, DG; Harris, AL; Potter, CG | 1 |
| Richardson, VJ; Ryman, BE | 1 |
| Curt, GA; Richardson, VJ; Ryman, BE | 1 |
| Danks, MK | 1 |
| Bakshi, D; Buscaglia, D; Early, AP; Kelly, E; Preisler, H; Rustum, YM; Slocum, HK; Wang, G; Wrzosek, C | 1 |
| Campbell, J; Mayhew, E; Rustum, YM; Szoka, F | 1 |
| Abe, I; Saito, S; Sato, H; Suzuki, M | 1 |
| Danhauser, LL; Rustum, YM | 1 |
| Cadman, E; Grant, S; Lehman, C | 1 |
| Myers-Robfogel, MW; Spataro, AC | 1 |
| Mazrimas, JA; Pallavicini, MG | 1 |
| Grindey, GB; Kinahan, JJ; Kowal, EP | 1 |
| Estey, E; Gandhi, V; Plunkett, W | 1 |
| Horber, DH; Schott, H; Schwendener, RA | 2 |
| Bhalla, K; Huang, Y; Ibrado, AM; Mahoney, ME; Tang, C; Tourkina, E | 1 |
| Nakamura, T; Takauji, R; Tohyama, K; Ueda, T | 1 |
| Bauer, S; Cinatl, J; Köhl, U; Mainke, M; Mieth, B; Montag, E; Rohrbach, E; Schwabe, D; Weissflog, A | 1 |
| Grant, S; Nelms, P; Turner, A; Yanovich, S | 1 |
| Avramis, VI; Ramilo-Torno, LV | 1 |
| Case, LD; Gregory, BW; Kucera, GL; Powell, BL; Wang, LM | 1 |
| Cubitt, S; Enns, L; Karimian, K; Mirzayans, R; Paterson, MC; Radatus, B | 1 |
| Bartimole, TM; Grant, S; Jarvis, WD; Joe, VC; Nelms, PA; Turner, AJ | 1 |
| Kawai, Y; Nakamura, T; Ueda, T | 1 |
| Barra, Y; Carcassonne, Y; Iliadis, A; Ressayre, C; Riva-Lavieille, C | 1 |
| Du, M; Gandhi, V; Kantarjian, HM; Plunkett, W | 1 |
| Milano, GA; Peters, GJ; Schornagel, JH | 1 |
| Gandhi, V; Keating, MJ; Plunkett, W; Robertson, LE | 1 |
| Ameling, C; Auf der Landwehr, U; Büchner, T; Hiddemann, W; Reuter, C; Rolf, C; Schleyer, E; Wörmann, B; Zühlsdorf, M | 1 |
| Estey, E; Hagemeister, FB; Hall, R; Kantarjian, HM; Keating, MJ; McLaughlin, P; Plunkett, W; Robertson, LE | 1 |
| Bennett, J; Browman, GP; Goldberg, J; Kukla, C; Larson, RA; Miller, KA; Preisler, HD; Raza, A; Rustum, YM; Vogler, R | 1 |
| Björkholm, M; Gruber, A; Knochenhauer, E; Liliemark, J; Peterson, C; Pettersson, B | 1 |
| Brach, MA; Herrmann, F; Mertelsmann, RH | 1 |
| Estey, E; Gandhi, V; Keating, MJ; Plunkett, W | 1 |
| Estey, EH; Kantarjian, H; Keating, MJ; Plunkett, W; Rios, MB | 1 |
| Malmberg, M; Minderman, H; Raymakers, RA; Rustum, YM; Slocum, HK | 1 |
| Chucrallah, A; Estey, E; Gandhi, V; Keating, MJ; Plunkett, W | 1 |
| Buck, SA; Gurney, JG; Matherly, LH; Ravindranath, Y; Stout, ML; Taub, JW | 1 |
| Nakamura, T; Ueda, T; Yamauchi, T | 1 |
| Kasperrs, GJ; Kazemier, KM; Noordhuis, P; Peters, GJ | 1 |
| Cuddy, D; Hickey, R; Malkas, L; Ross, D; Wills, P | 1 |
| Estey, EH; Gandhi, V; Keating, MJ; Plunkett, W | 1 |
| Diaz-Perez, MJ; Price, GB; Wainer, IW; Zannis-Hadjopoulos, M | 1 |
| Cao, DC; Higashigawa, M; Hori, H; Ido, M; Kawasaki, H; Komada, Y; Kuwabara, H; Ohkubo, T; Sakurai, M | 1 |
| Andreeff, HM; Beran, M; Estey, E; Gandhi, V; Kantarjian, HM; Koller, CA; Kornblau, SM; O'Brien, S; Plunkett, W | 1 |
| Büchner, T; Hiddemann, W; Kern, W; Schleyer, E; Unterhalt, M | 1 |
| Iwasaki, H; Kamiya, K; Kawai, Y; Nakamura, T; Takauji, R; Tohyama, K; Ueda, T; Yamauchi, T | 1 |
| Akiyama, Y; Furusho, K; Kataoka, A; Koishi, S; Kubota, M; Lin, YW; Sawada, M; Usami, I; Watanabe, Ki | 1 |
| Berkovic, D; Breass, J; Fleer, EA; Hiddemann, W; Pförtner, J; Schleyer, E | 1 |
| Avramis, VI; Kowck, R; Krailo, MD; Liu-Mares, W; Ramilo-Torno, LV; Reaman, GH; Sato, JK; Sharpe, A; Wiersma, S | 1 |
| Heinemann, V; Issels, RD; Schulz, L; Wilmanns, W | 1 |
| Alton, P; Elgie, AW; Noordhuis, P; Peters, GJ; Sargent, JM; Taylor, CG; Williamson, CJ | 1 |
| Estey, E; Gandhi, V; Xu, YZ | 1 |
| Du, M; Estey, E; Gandhi, V; Keating, MJ; Plunkett, W | 1 |
| Gandhi, V; Huang, P; Plunkett, W; Seymour, JF | 1 |
| Boos, J; Freund, A; Gescher, A; Hohenlöchter, B; Jürgens, H; Lanvers, C; Rössig, C | 1 |
| Abdel-Aziz, W; Hickey, RJ; Jiang, HY; Malkas, LH | 2 |
| Braess, J; Hiddemann, W; Jahns-Streubel, G; Kern, W; Keye, S; Schleyer, E; Unterhalt, M; Wegendt, C | 1 |
| Hickey, R; Malkas, L; Wills, PW | 1 |
| Bergman, AM; Jensen, PB; Munch-Petersen, B; Peters, GJ; Pinedo, HM; Sehested, M; Smid, K; Veerman, G; Voorn, DA | 1 |
| Fukushima, T; Goto, N; Imamura, S; Iwasaki, H; Kawai, Y; Kishi, S; Masada, M; Tsutani, H; Ueda, T; Urasaki, Y; Yamauchi, T; Yoshida, A | 2 |
| Borutaite, V; Tolkovsky, AM; Xue, L | 1 |
| Elford, HL; Fritzer-Szekeres, M; Grusch, M; Höchtl, T; Horvath, Z; Jäger, W; Krupitza, G; Salamon, A; Steinbrugger, R; Szekeres, T | 1 |
| Behm, FG; Crews, KR; Gandhi, V; Plunkett, W; Pui, CH; Raimondi, SC; Razzouk, BI; Ribeiro, RC; Rubnitz, JE; Srivastava, DK; Stewart, CF; Tong, X | 1 |
| Armstrong, SA; den Boer, ML; Ebus, ME; Janka-Schaub, GE; Korsmeyer, SJ; Meijerink, JP; Noordhuis, P; Peters, GJ; Pieters, R; Stam, RW | 1 |
| Dai, Y; Decker, RH; Grant, S; Kramer, LB; Levin, J | 1 |
| Clarke, ML; Cros, E; Dumontet, C; Galmarini, CM; Gosselin, G; Jordheim, L; Mackey, JR; Perigaud, C; Santos, CL | 1 |
| Bauer, W; Elford, HL; Fritzer-Szekeres, M; Höchtl, T; Horvath, Z; Karl, D; Saiko, P; Szekeres, T | 1 |
| Biesma, DH; Daenen, SM; Delforge, M; Graveland, WJ; Löwenberg, B; Muus, P; Noordhuis, P; Ossenkoppele, GJ; Peters, GJ; Schaafsma, MR; Selleslag, D; Sonneveld, P; van der Holt, B; Verdonck, LF; Verhoef, GE; Westveer, PH | 1 |
| Abdel-Aziz, W; Hickey, RJ; Malkas, LH | 1 |
| Buck, S; Ge, Y; Jensen, TL; Matherly, LH; Ravindranath, Y; Stout, ML; Tatman, DA; Taub, JW; Thomas, RL | 1 |
| Kolb, JP | 1 |
| Barge, RM; de Vries, JF; Falkenburg, JH; Willemze, R | 1 |
| Nishi, R; Ueda, T; Yamauchi, T | 1 |
| Cinatl, J; Hollatz, G; Koehl, U; Kornhuber, B; Kreuter, J; Mutschler, E; Rohrbach, E; Schwabe, D; Visschedyk, K | 1 |
| Iwasaki, H; Kawai, Y; Kishi, S; Takemura, H; Ueda, T; Urasaki, Y; Yamamoto, S; Yamauchi, T; Yoshida, A | 1 |
| Bergman, AM; Hoebe, EK; Kamphuis, JA; Laan, AC; Peters, GJ; Sigmond, J | 1 |
| Galmarini, CM; Kohli, E; Mitin, A; Vinogradov, SV; Warren, G; Zeman, A | 1 |
| Iwasaki, H; Kishi, S; Negoro, E; Takagi, K; Ueda, T; Urasaki, Y; Yamauchi, T; Yoshida, A | 1 |
| Lamba, JK | 1 |
| Jiang, S; Qiao, X; Shao, Y; Shi, W; Tang, J; Xie, X; Zhang, X; Zhou, X | 1 |
| Alloush, H; Anderson, E; Conway, M; Lamont, J; Martin, A; Mehta, P; Ruddock, M; Salisbury, V; Smith, JG; Smith, MA | 1 |
| Alloush, H; Anderson, E; Conway, M; Fitzgerald, SP; Lamont, J; Martin, A; Mehta, P; O'Malley, K; Reid, C; Ruddock, M; Salisbury, V; Smith, JG; Smith, MA | 1 |
| Jiang, X; Liang, D; Wang, W; Yin, S | 1 |
| Anderson, E; Salisbury, V | 1 |
| Axelsson, H; Bladh, J; Bulli, L; Calderón-Montaño, JM; Grandér, D; Hagenkort, A; Helleday, T; Henter, JI; Herold, N; Heshmati, Y; Heyman, M; Höglund, A; Jemth, AS; Kogner, P; Kutzner, J; Lehmann, S; Ljungblad, L; Loseva, O; Lundbäck, T; Myrberg, IH; Page, BD; Paulin, CB; Rassidakis, G; Rudd, SG; Sanjiv, K; Schaller, T; Sundin, M; Tamm, KP; Tesi, B; Uhlin, M; Valerie, NC; Walfridsson, J; Warpman-Berglund, U; Wiita, E | 1 |
| Axelsson, H; Branca, RM; Bunten, SS; Coggins, SA; Grandér, D; Hed Myrberg, I; Helleday, T; Henter, JI; Herold, N; Heyman, M; Kim, B; Kutzner, J; Lee, S; Lehmann, S; Lehtiö, J; Lundbäck, T; Mäkelä, P; Mermelekas, G; Paulin, CB; Pokrovskaja Tamm, K; Qian, H; Rassidakis, GZ; Rasti, A; Rudd, SG; Sandhow, L; Sanjiv, K; Schaller, T; Schinazi, RF; Suman, S; Tao, S; Tsesmetzis, N; Walfridsson, J; Warpman-Berglund, U; Wiita, E; Zhang, SM | 1 |
| Huang, C; Huang, S; Liu, L; Liu, X; Miao, L; Song, L | 1 |
| Alonzo, TA; Aplenc, R; Cao, X; Elsayed, AH; Klco, JM; Kolb, EA; Lamba, JK; Ma, X; Marrero, RJ; Meshinchi, S; Pounds, SB; Ribeiro, RC; Ries, RE; Rubnitz, JE; Wu, H | 1 |
12 review(s) available for cytarabine and arabinofuranosylcytosine triphosphate
| Article | Year |
|---|---|
Pharmacologically directed design of leukemia therapy.
Topics: Antineoplastic Combined Chemotherapy Protocols; Arabinofuranosylcytosine Triphosphate; Arabinonucleotides; Cytarabine; Drug Evaluation; Humans; Leukemia; Leukemia, Myeloid, Acute; Mitoxantrone | 1990 |
Rationales for a pharmacologically optimized treatment of acute nonlymphocytic leukemia with cytosine arabinoside.
Topics: Arabinofuranosylcytosine Triphosphate; Biological Transport; Cytarabine; Deamination; Drug Administration Schedule; Drug Resistance; Humans; Infusions, Intravenous; Leukemia, Myeloid, Acute; Phosphorylation; Recurrence | 1990 |
Sequential high-dose ara-C and asparaginase in the therapy of previously treated and untreated patients with acute leukemia.
Topics: Aging; Animals; Antineoplastic Combined Chemotherapy Protocols; Arabinofuranosylcytosine Triphosphate; Asparaginase; Child; Clinical Trials as Topic; Cytarabine; Daunorubicin; DNA; Dose-Response Relationship, Drug; Drug Resistance; Humans; Kinetics; Leukemia; Leukemia, Lymphoid; Middle Aged; Time Factors | 1985 |
Studies on the cytotoxicity of cytosine arabinoside.
Topics: Adolescent; Adult; Arabinofuranosylcytosine Triphosphate; Bone Marrow; Cell Cycle; Cell Differentiation; Cells, Cultured; Clone Cells; Colony-Forming Units Assay; Cytarabine; DNA; Drug Resistance; Female; Granulocytes; Half-Life; Humans; Interphase; Kinetics; Leukemia; Male; Middle Aged; Phosphorylation; Recurrence | 1985 |
Cytosine arabinoside in experimental combination therapy.
Topics: Aminoacridines; Amsacrine; Animals; Antineoplastic Combined Chemotherapy Protocols; Arabinofuranosylcytosine Triphosphate; Cisplatin; Cyclophosphamide; Cytarabine; Daunorubicin; DNA; DNA Repair; Doxorubicin; Drug Interactions; Drug Resistance; Humans; Interphase; Leukemia; Mercaptopurine; Phosphorylation; Thioguanine; Thymidine; Time Factors | 1985 |
Biochemical and cellular pharmacology of cytosine arabinoside.
Topics: Animals; Aphidicolin; Arabinofuranosylcytosine Triphosphate; Binding, Competitive; Cell Line; Cell Survival; Centrifugation, Density Gradient; Cytarabine; Diterpenes; DNA; DNA Repair; DNA Replication; Fibroblasts; Granulocytes; Humans; Kinetics; Leukemia L1210; Leukemia, Myeloid, Acute; Nucleic Acid Synthesis Inhibitors; Templates, Genetic; Vidarabine | 1985 |
Modulation of arabinosylcytosine metabolism during leukemia therapy.
Topics: Antineoplastic Agents; Arabinofuranosylcytosine Triphosphate; Biotransformation; Cytarabine; Granulocyte Colony-Stimulating Factor; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; Leukemia; Vidarabine | 1994 |
Clinical pharmacokinetics of anti-metabolites.
Topics: Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Arabinofuranosylcytosine Triphosphate; Cytarabine; Fluorouracil; Humans; Mercaptopurine; Methotrexate; Neoplasms | 1993 |
Modulation of cytotoxicity and differentiation-inducing potential of arabinofuranosylcytosine in myeloid leukemia cells by hematopoietic cytokines.
Topics: Acute Disease; Arabinofuranosylcytosine Triphosphate; Cell Differentiation; Cell Division; Colony-Stimulating Factors; Cytarabine; Drug Combinations; Growth Inhibitors; Hematopoietic Cell Growth Factors; Humans; Interleukin-6; Leukemia Inhibitory Factor; Leukemia, Myeloid; Lymphokines; Tumor Cells, Cultured; Tumor Stem Cell Assay | 1993 |
Biochemical modulation of arabinosylcytosine for therapy of leukemias.
Topics: Antineoplastic Combined Chemotherapy Protocols; Arabinofuranosylcytosine Triphosphate; Cytarabine; Humans; Leukemia; Leukemia, Lymphocytic, Chronic, B-Cell; Leukemia, Myeloid, Acute; Vidarabine | 1993 |
Intracellular pharmacodynamics in leukemia therapy.
Topics: Antineoplastic Combined Chemotherapy Protocols; Arabinofuranosylcytosine Triphosphate; Cytarabine; Humans; Leukemia; Mitoxantrone; Vidarabine | 1996 |
Genetic factors influencing cytarabine therapy.
Topics: 5'-Nucleotidase; Antimetabolites, Antineoplastic; Arabinofuranosylcytosine Triphosphate; Cytarabine; Cytidine Deaminase; Deoxycytidine Kinase; Equilibrative Nucleoside Transporter 1; Forecasting; Genetic Variation; Humans; Leukemia, Myeloid, Acute; Nucleoside Deaminases; Pharmacogenetics; Ribonucleotide Reductases | 2009 |
9 trial(s) available for cytarabine and arabinofuranosylcytosine triphosphate
| Article | Year |
|---|---|
High-dose versus intermediate-dose cytosine arabinoside in combination with mitoxantrone for the treatment of relapsed and refractory acute myeloid leukemia--preliminary clinical and pharmacological data of a randomized comparison.
Topics: Antineoplastic Combined Chemotherapy Protocols; Arabinofuranosylcytosine Triphosphate; Cytarabine; Humans; Leukemia, Myeloid, Acute; Middle Aged; Mitoxantrone; Recurrence | 1990 |
Effect of amsacrine on ara-CTP cellular pharmacology in human leukemia cells during high-dose cytarabine therapy.
Topics: Acute Disease; Adult; Aged; Amsacrine; Antineoplastic Combined Chemotherapy Protocols; Arabinofuranosylcytosine Triphosphate; Arabinonucleotides; Cells, Cultured; Cytarabine; Female; Humans; Leukemia; Male; Middle Aged | 1987 |
Sequential high-dose ara-C and asparaginase in the therapy of previously treated and untreated patients with acute leukemia.
Topics: Aging; Animals; Antineoplastic Combined Chemotherapy Protocols; Arabinofuranosylcytosine Triphosphate; Asparaginase; Child; Clinical Trials as Topic; Cytarabine; Daunorubicin; DNA; Dose-Response Relationship, Drug; Drug Resistance; Humans; Kinetics; Leukemia; Leukemia, Lymphoid; Middle Aged; Time Factors | 1985 |
Chlorodeoxyadenosine and arabinosylcytosine in patients with acute myelogenous leukemia: pharmacokinetic, pharmacodynamic, and molecular interactions.
Topics: Adenosine Triphosphate; Adult; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Arabinofuranosylcytosine Triphosphate; Base Sequence; Biotransformation; Cladribine; Cytarabine; DNA Replication; DNA, Neoplasm; Humans; Leukemia, Myeloid, Acute; Molecular Sequence Data; Neoplasm Proteins; Neoplastic Stem Cells; Prodrugs; Ribonucleotide Reductases; Salvage Therapy | 1996 |
Heterogeneous effects of G-CSF and GM-CSF on cell growth and ara-C cytotoxicity in childhood leukemias which express myeloid markers.
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Arabinofuranosylcytosine Triphosphate; Cell Division; Child; Child, Preschool; Cytarabine; Drug Synergism; Female; Granulocyte Colony-Stimulating Factor; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; Immunophenotyping; Infant; Leukemia, Myeloid, Acute; Leukemia, Myelomonocytic, Acute; Leukemia, Promyelocytic, Acute; Male; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Thymidine; Tritium | 1996 |
Clinical and laboratory studies of 2-chlorodeoxyadenosine +/- cytosine arabinoside for relapsed or refractory acute myelogenous leukemia in adults.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Arabinofuranosylcytosine Triphosphate; Cladribine; Cytarabine; Humans; Leukemia, Myeloid, Acute; Middle Aged; Recurrence | 1996 |
Pharmacokinetic and pharmacodynamic studies of fludarabine and cytosine arabinoside administered as loading boluses followed by continuous infusions after a phase I/II study in pediatric patients with relapsed leukemias. The Children's Cancer Group.
Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Arabinofuranosylcytosine Triphosphate; Child; Child, Preschool; Cytarabine; Humans; Infant; Leukemia, Myeloid, Acute; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Vidarabine | 1998 |
Interim comparison of a continuous infusion versus a short daily infusion of cytarabine given in combination with cladribine for pediatric acute myeloid leukemia.
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Arabinofuranosylcytosine Triphosphate; Bone Marrow; Child; Child, Preschool; Cladribine; Cytarabine; Daunorubicin; Drug Administration Schedule; Etoposide; Female; Humans; Infant; Leukemia, Myeloid, Acute; Male; Remission Induction | 2002 |
The value of fludarabine in addition to ARA-C and G-CSF in the treatment of patients with high-risk myelodysplastic syndromes and AML in elderly patients.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Arabinofuranosylcytosine Triphosphate; Cytarabine; Disease-Free Survival; Female; Filgrastim; Granulocyte Colony-Stimulating Factor; Hematopoiesis; Humans; In Vitro Techniques; Leukemia, Myeloid, Acute; Male; Middle Aged; Myelodysplastic Syndromes; Prognosis; Recombinant Proteins; Risk Factors; Survival Rate; Vidarabine | 2004 |
182 other study(ies) available for cytarabine and arabinofuranosylcytosine triphosphate
| Article | Year |
|---|---|
Use of liposomes for the enhancement of the cytotoxic effects of cytosine arabinoside.
Topics: Animals; Arabinofuranosylcytosine Triphosphate; Cytarabine; Drug Synergism; Female; Leukemia L1210; Liposomes; Mice; Mice, Inbred DBA; Pharmaceutical Vehicles; Phosphatidylcholines; Phosphatidylserines; Pregnancy; Tissue Distribution | 1978 |
Correlation between leukemic cell retention of 1-beta-D-arabinofuranosylcytosine 5'-triphosphate and response to therapy.
Topics: Adult; Aged; Antineoplastic Agents; Arabinofuranosylcytosine Triphosphate; Arabinonucleotides; Bone Marrow; Cytarabine; Drug Therapy, Combination; Female; Humans; In Vitro Techniques; Leukemia, Myeloid, Acute; Male; Middle Aged; Remission, Spontaneous; Time Factors | 1979 |
Multiple determinants of antimetabolite action in humans.
Topics: Animals; Antimetabolites, Antineoplastic; Arabinofuranosylcytosine Triphosphate; Arabinofuranosyluracil; Cytarabine; Daunorubicin; Deamination; DNA; Doxorubicin; Drug Resistance; Humans; Leukemia, Myeloid, Acute; Neoplasms, Experimental | 1979 |
Mechanism of synergistic cell killing when methotrexate precedes cytosine arabinoside: study of L1210 and human leukemic cells.
Topics: Animals; Arabinofuranosylcytosine Triphosphate; Cell Survival; Cells, Cultured; Cytarabine; Deoxyribonucleotides; Drug Synergism; Humans; In Vitro Techniques; Leukemia L1210; Leukemia, Myeloid, Acute; Methotrexate; Mice | 1979 |
Prediction of therapeutic response in acute myelocytic leukemia.
Topics: Arabinofuranosylcytosine Triphosphate; Benzimidazoles; Biological Transport; Cytarabine; DNA, Neoplasm; Doxorubicin; Drug Therapy, Combination; Fluorescence; Fluorescent Dyes; Humans; Leukemia, Myeloid, Acute; Phosphorylation | 1979 |
Biochemical determinants for antileukemia drug treatment.
Topics: Adenosine Deaminase; Adenosine Deaminase Inhibitors; Arabinofuranosylcytosine Triphosphate; Coformycin; Cytarabine; Humans; Leukemia; Methotrexate; Pentostatin; Phosphorylation; Tissue Distribution | 1979 |
Dephosphorylation of nucleotides of 1-beta-D-arabinofuranosylcytosine in relation to the different drug sensitivity in tumor cells.
Topics: Adenosine Triphosphate; Animals; Arabinofuranosylcytosine Triphosphate; Arabinonucleotides; Cells, Cultured; Cytarabine; Depression, Chemical; Drug Resistance; Half-Life; Iodoacetates; Liver Neoplasms, Experimental; Mice; Phosphorylation; Rats | 1979 |
Studies on biologically active nucleosides and nucleotides. 5. Synthesis and antitumor activity of some 2,2'-anhydro-1-(3',5'-di-O-acyl-beta-D-arabinofuranosyl)cytosine salts and 2,2'-anhydro-1-(3'-O-acyl-beta-D-arabinofuranoxyl)cytosine 5'-phosphates.
Topics: Animals; Antineoplastic Agents; Arabinofuranosylcytosine Triphosphate; Arabinonucleotides; Cytarabine; Female; Leukemia L1210; Methods; Mice; Structure-Activity Relationship | 1979 |
Methotrexate-induced changes in the levels of 1-beta-D-arabinofuranosylcytosine triphosphate in L1210 cells.
Topics: Animals; Arabinofuranosylcytosine Triphosphate; Arabinofuranosyluracil; Arabinonucleotides; Cytarabine; Deoxycytidine Kinase; Drug Therapy, Combination; Female; Leukemia L1210; Methotrexate; Mice; Mice, Inbred Strains; Time Factors | 1979 |
Effect of cytosine arabinoside triphosphate on the incorporation of 3H-thymidine in mitochondria isolated from HeLa cells.
Topics: Arabinofuranosylcytosine Triphosphate; Arabinonucleotides; Cell-Free System; Cytarabine; Deoxycytidine; DNA, Mitochondrial; DNA, Neoplasm; Ethidium; HeLa Cells; Humans; Mitochondria; Thymidine | 1979 |
A radioimmunoassay for cytosine arabinoside.
Topics: Animals; Arabinofuranosylcytosine Triphosphate; Arabinofuranosyluracil; Cross Reactions; Cytarabine; Humans; Immune Sera; Ovalbumin; Radioimmunoassay; Sheep | 1979 |
Differences in the intracellular pharmacokinetics of cytosine arabinoside (AraC) between circulating leukemic blasts and normal mononuclear blood cells.
Topics: Acute Disease; Antineoplastic Combined Chemotherapy Protocols; Arabinofuranosylcytosine Triphosphate; Arabinofuranosyluracil; Cytarabine; Daunorubicin; Drug Administration Schedule; Humans; Leukemia, Myeloid; Leukocytes, Mononuclear; Lymphoma, Non-Hodgkin; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Thioguanine | 1992 |
Cell cycle-specific metabolism of arabinosyl nucleosides in K562 human leukemia cells.
Topics: Antineoplastic Agents; Arabinofuranosylcytosine Triphosphate; Arabinonucleotides; Cell Cycle; Cytarabine; Deoxycytidine Kinase; Drug Synergism; G1 Phase; G2 Phase; Humans; Intracellular Fluid; Leukemia, Lymphocytic, Chronic, B-Cell; Leukemia, Myeloid, Acute; Metaphase; Nucleotides; S Phase; Sensitivity and Specificity; Tumor Cells, Cultured; Vidarabine | 1992 |
Effects of bryostatin 1 and rGM-CSF on the metabolism of 1-beta-D-arabinofuranosylcytosine in human leukaemic myeloblasts.
Topics: Antineoplastic Agents; Arabinofuranosylcytosine Triphosphate; Bryostatins; Cytarabine; Drug Interactions; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; Lactones; Leukemia, Myeloid, Acute; Macrolides; Recombinant Proteins; Time Factors | 1992 |
Human immunodeficiency virus type 1 induces 1-beta-D-arabinofuranosylcytosine resistance in human H9 cell line.
Topics: Arabinofuranosylcytosine Triphosphate; Cell Division; Cell Line; Cell Survival; Cytarabine; Cytidine Deaminase; Deoxycytidine Kinase; Deoxyribonucleotides; Drug Resistance; HIV-1; Humans; Kinetics; Tetrahydrouridine | 1992 |
Granulocyte-macrophage colony-stimulating factor and interleukin-3 enhance the incorporation of cytosine arabinoside into the DNA of leukemic blasts and the cytotoxic effect on clonogenic cells from patients with acute myeloid leukemia.
Topics: Acute Disease; Arabinofuranosylcytosine Triphosphate; Blast Crisis; Cytarabine; DNA, Neoplasm; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; Interleukin-3; Leukemia, Myeloid; S Phase; Tumor Stem Cell Assay | 1992 |
Enhancement of the cytotoxicity of cytosine arabinoside by interleukin-3.
Topics: Acute Disease; Arabinofuranosylcytosine Triphosphate; Blast Crisis; Cytarabine; Drug Synergism; Feasibility Studies; Humans; Interleukin-1; Interleukin-3; Leukemia, Myeloid; Tumor Stem Cell Assay | 1992 |
Intracellular cytosine arabinoside accumulation and cytosine arabinoside triphosphate formation in leukemic blast cells is inhibited by etoposide and teniposide.
Topics: Acute Disease; Adult; Aged; Amsacrine; Arabinofuranosylcytosine Triphosphate; Cytarabine; Drug Interactions; Etoposide; Humans; Leukemia; Middle Aged; Neoplastic Stem Cells; Phosphorylation; Teniposide; Tumor Cells, Cultured | 1992 |
Biotransformation and in vitro activity of an arabinosylcytosine 5'-chloro-5'-deoxy analog.
Topics: Animals; Antineoplastic Agents; Arabinofuranosylcytosine Triphosphate; Biotransformation; Chromatography, High Pressure Liquid; Colorectal Neoplasms; Culture Media; Cytarabine; DNA, Neoplasm; Hydrogen-Ion Concentration; Leukemia L1210; Phosphorylation; Pyrimidine Nucleosides; Temperature; Tumor Cells, Cultured | 1991 |
Treatment with interleukin-3 plus granulocyte-macrophage colony-stimulating factors improves the selectivity of Ara-C in vitro against acute myeloid leukemia blasts.
Topics: Acute Disease; Arabinofuranosylcytosine Triphosphate; Blast Crisis; Bone Marrow Cells; Cells, Cultured; Colony-Forming Units Assay; Cytarabine; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; Interleukin-3; Kinetics; Leukemia, Myeloid; Monocytes; Recombinant Proteins; Reference Values; Stem Cells; Tumor Cells, Cultured | 1991 |
In vitro effects of bryostatin 1 on the metabolism and cytotoxicity of 1-beta-D-arabinofuranosylcytosine in human leukemia cells.
Topics: Antineoplastic Agents; Arabinofuranosylcytosine Triphosphate; Bryostatins; Cell Count; Cytarabine; Diterpenes; DNA, Neoplasm; Humans; Kinetics; Lactones; Leukemia, Experimental; Leukemia, Myeloid; Macrolides; Phorbol 12,13-Dibutyrate; Phosphorylation; Terpenes; Time Factors; Tumor Cells, Cultured | 1991 |
Intracellular dCTP/ara-CTP ratio and the cytotoxic effect of ara-C.
Topics: Arabinofuranosylcytosine Triphosphate; Cell Division; Chromatography, High Pressure Liquid; Culture Media; Cytarabine; Deoxycytosine Nucleotides; DNA, Neoplasm; Humans; Tumor Cells, Cultured | 1991 |
Decreased DNA polymerase sensitivity to 1-beta-D-arabinofuranosylcytosine 5'-triphosphate in P388 murine leukemic cells resistant to vincristine.
Topics: Animals; Arabinofuranosylcytosine Triphosphate; Blotting, Western; Cytarabine; DNA-Directed DNA Polymerase; Doxorubicin; Drug Resistance; Etoposide; Intracellular Fluid; Leukemia P388; Mice; Nucleic Acid Synthesis Inhibitors; Thymine Nucleotides; Tumor Cells, Cultured; Vincristine | 1991 |
Effects of thymidine and hydroxyurea on the metabolism and cytotoxicity of 1-B-D arabinofuranosylcytosine in highly resistant human leukemia cells.
Topics: Arabinofuranosylcytosine Triphosphate; Cell Cycle; Cell Survival; Cytarabine; DNA; Drug Resistance; Humans; Hydroxyurea; In Vitro Techniques; Leukemia, Myeloid; Thymidine; Tumor Cells, Cultured | 1991 |
Mechanism of inhibition of DNA ligase in Ara-C treated cells.
Topics: Adenosine Monophosphate; Arabinofuranosylcytosine Triphosphate; Cytarabine; DNA Ligases; Humans; Hydroxyurea; Leukemia, Myeloid; Tumor Cells, Cultured | 1991 |
Effect of tetrahydrouridine and deoxytetrahydrouridine on the interaction between 2'-deoxycytidine and 1-beta-D-arabinofuranosylcytosine in human leukemia cells.
Topics: Arabinofuranosylcytosine Triphosphate; Cell Division; Cytarabine; Cytidine Deaminase; DCMP Deaminase; Deamination; Deoxycytidine; Deoxycytosine Nucleotides; DNA, Neoplasm; Humans; Leukemia; Tetrahydrouridine; Tumor Cells, Cultured | 1991 |
Membrane transport of 1-beta-D-arabinofuranosylcytosine and accumulation of 1-beta-D-arabinofuranosylcytosine 5'-triphosphate in P388 murine leukemic cells resistant to vincristine.
Topics: Animals; Arabinofuranosylcytosine Triphosphate; Binding Sites; Biological Transport; Cell Membrane; Cytarabine; Drug Resistance; Leukemia P388; Mice; Mice, Inbred Strains; Thioinosine; Tumor Cells, Cultured; Vincristine | 1991 |
Potentiation of 1-beta-D-arabinofuranosylcytosine cytotoxicity to HL-60 cells by 1,25-dihydroxyvitamin D3 correlates with reduced rate of maturation of DNA replication intermediates.
Topics: Arabinofuranosylcytosine Triphosphate; Calcitriol; Cell Differentiation; Cell Survival; Cytarabine; DNA Damage; DNA Replication; Drug Administration Schedule; Drug Synergism; Humans; Structure-Activity Relationship; Tumor Cells, Cultured | 1991 |
[Studies on intracellular kinetics of ara-C triphosphate in HL-60, human leukemia cells in relation to reasonable administration of ara-C].
Topics: Arabinofuranosylcytosine Triphosphate; Biological Transport, Active; Biotransformation; Cytarabine; Humans; Leukemia, Myeloid, Acute; Tumor Cells, Cultured | 1990 |
Concordant changes of pyrimidine metabolism in blasts of two cases of acute myeloid leukemia after repeated treatment with ara-C in vivo.
Topics: Adolescent; Adult; Arabinofuranosylcytosine Triphosphate; Cytarabine; DCMP Deaminase; Deoxycytidine Kinase; Deoxycytosine Nucleotides; Drug Resistance; Female; Humans; Leukemia, Myeloid, Acute; Male; Pyrimidines; Thymine Nucleotides | 1990 |
Cellular pharmacology of 1-beta-D-arabinofuranosylcytosine in human myeloid, B-lymphoid and T-lymphoid leukemic cells.
Topics: Arabinofuranosylcytosine Triphosphate; Cell Line; Cells, Cultured; Chromatography, High Pressure Liquid; Cytarabine; Deoxycytidine Kinase; DNA, Neoplasm; Humans; Leukemia, B-Cell; Leukemia, Lymphoid; Leukemia, Myeloid; Leukemia, T-Cell; Phosphorylation | 1990 |
Deoxyribonucleoside triphosphate pools and Ara-CTP levels in P388 murine leukemic cells treated with 1-B-D-arabinofuranosylcytosine-5'-stearylphosphate which is a newly synthesized derivative of 1-B-D-arabinofuranosylcytosine.
Topics: Administration, Oral; Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Arabinofuranosylcytosine Triphosphate; Arabinonucleotides; Chromatography, High Pressure Liquid; Cytarabine; Cytidine Monophosphate; Deoxyribonucleotides; Leukemia P388; Male; Mice | 1990 |
Cellular ara-CTP pharmacokinetics, response, and karyotype in newly diagnosed acute myelogenous leukemia.
Topics: Amsacrine; Arabinofuranosylcytosine Triphosphate; Arabinonucleotides; Chromosome Deletion; Chromosome Inversion; Cytarabine; Drug Resistance; Humans; Karyotyping; Leukemia, Myeloid, Acute | 1990 |
Pharmacokinetics of cytosine arabinoside in cerebrospinal fluid and of its metabolite in leukemic cells.
Topics: Arabinofuranosylcytosine Triphosphate; Arabinonucleotides; Catheterization; Child; Cytarabine; Female; Humans; Hydrocortisone; Injections, Intraventricular; Lumbar Vertebrae; Meningeal Neoplasms; Neoplasm Recurrence, Local; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Time Factors | 1990 |
The effect of ara-C-induced inhibition of DNA synthesis on its cellular pharmacology.
Topics: Animals; Arabinofuranosylcytosine Triphosphate; Cytarabine; Depression, Chemical; DNA-Directed DNA Polymerase; DNA, Neoplasm; Leukemia L5178; Mice; Ribonucleoside Diphosphate Reductase; Thymidine; Thymidine Kinase; Thymine Nucleotides; Tumor Cells, Cultured; Tumor Stem Cell Assay | 1990 |
Saturation of intracellular cytosine arabinoside triphosphate accumulation in human leukemic blast cells.
Topics: Acute Disease; Arabinofuranosylcytosine Triphosphate; Arabinonucleotides; Binding Sites; Biological Transport; Cell Membrane; Cytarabine; Deoxycytidine Kinase; Extracellular Space; Humans; Leukemia; Lymphocytes; Nucleosides; Phosphorylation; Thioinosine; Tumor Cells, Cultured | 1990 |
Metabolic basis of arabinonucleoside selectivity for human leukemic T- and B-lymphoblasts.
Topics: Arabinofuranosylcytosine Triphosphate; Arabinonucleosides; B-Lymphocytes; Cell Line; Cell Survival; Cytarabine; Deoxyguanosine; Humans; Leukemia; Phosphorylation; T-Lymphocytes; Vidarabine; Vidarabine Phosphate | 1985 |
Differential modulation of 1-beta-D-arabinofuranosylcytosine metabolism by hydroxyurea in human leukemic cell lines.
Topics: Arabinofuranosylcytosine Triphosphate; Arabinonucleotides; B-Lymphocytes; Cell Line; Cytarabine; Deoxyadenine Nucleotides; Deoxyadenosines; Deoxycytidine; Deoxycytosine Nucleotides; Humans; Hydroxyurea; Leukemia; T-Lymphocytes; Thymine Nucleotides; Vidarabine Phosphate | 1988 |
Pharmacodynamic and DNA methylation studies of high-dose 1-beta-D-arabinofuranosyl cytosine before and after in vivo 5-azacytidine treatment in pediatric patients with refractory acute lymphocytic leukemia.
Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Arabinofuranosylcytosine Triphosphate; Azacitidine; Child; Child, Preschool; Cytarabine; Deoxycytidine Kinase; DNA, Neoplasm; Drug Resistance; Drug Screening Assays, Antitumor; Female; Gene Expression Regulation; Humans; Male; Methylation; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Remission Induction; Tumor Cells, Cultured | 1989 |
Modulation of arabinosylcytosine metabolism by arabinosyl-2-fluoroadenine in lymphocytes from patients with chronic lymphocytic leukemia: implications for combination therapy.
Topics: Antineoplastic Combined Chemotherapy Protocols; Arabinofuranosylcytosine Triphosphate; Arabinonucleotides; Cytarabine; Drug Evaluation; Humans; Leukemia, Lymphocytic, Chronic, B-Cell; Lymphocytes; Vidarabine Phosphate | 1989 |
Interaction of arabinosyl nucleotides in K562 human leukemia cells.
Topics: Arabinofuranosylcytosine Triphosphate; Arabinonucleosides; Arabinonucleotides; Cytarabine; Deoxyribonucleotides; Drug Interactions; Guanosine Triphosphate; Humans; Leukemia; Phosphorylation; Phosphotransferases; Tumor Cells, Cultured; Vidarabine; Vidarabine Phosphate | 1989 |
Efficient formation of cytosine arabinoside-5'-triphosphate in leukemic blasts of human T-cell acute lymphoblastic leukemia.
Topics: Adolescent; Adult; Antigens, CD; Arabinofuranosylcytosine Triphosphate; Arabinonucleotides; Cytarabine; Humans; Interphase; Leukemia-Lymphoma, Adult T-Cell; Leukemia, Myeloid, Acute; Middle Aged; Mitoxantrone | 1989 |
Sequential combination of methotrexate and 1-beta-D-arabinofuranosylcytosine shows synergistic effect on the generation of DNA strand breaks in a human promyelocytic leukemia cell line.
Topics: Arabinofuranosylcytosine Triphosphate; Cycloheximide; Cytarabine; DNA Damage; DNA, Neoplasm; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Synergism; Humans; Hypoxanthine; Hypoxanthines; Leucovorin; Leukemia, Promyelocytic, Acute; Methotrexate; Thymidine; Tumor Cells, Cultured | 1989 |
Ara-CTP metabolism following hydroxyurea or methotrexate treatment in human leukemia cell lines.
Topics: Arabinofuranosylcytosine Triphosphate; Arabinonucleotides; Cytarabine; Deoxycytidine; Deoxycytosine Nucleotides; Drug Synergism; Humans; Hydroxyurea; Leukemia; Leukemia, Promyelocytic, Acute; Methotrexate; Thymine Nucleotides; Tumor Cells, Cultured | 1989 |
Relationship between intracellular dCTP/ara-CTP ratio and cytotoxic effect of ara-C.
Topics: Animals; Arabinofuranosylcytosine Triphosphate; Arabinonucleotides; Cytarabine; Deoxycytosine Nucleotides; Dose-Response Relationship, Drug; Humans; Leukemia, Myeloid; Leukemia, T-Cell; Mice; Spleen; Time Factors; Tumor Cells, Cultured | 1989 |
Patient-specific dose rate for continuous infusion high-dose cytarabine in relapsed acute myelogenous leukemia.
Topics: Adult; Arabinofuranosylcytosine Triphosphate; Cytarabine; Drug Administration Schedule; Female; Humans; Leukemia, Myeloid, Acute; Male; Middle Aged | 1989 |
Augmentation of 1-beta-D-arabinofuranosylcytosine cytotoxicity in human tumor cells by inhibiting drug efflux.
Topics: Antineoplastic Combined Chemotherapy Protocols; Arabinofuranosylcytosine Triphosphate; Cytarabine; Dipyridamole; DNA Damage; Drug Synergism; Humans; Tumor Cells, Cultured | 1989 |
Development of resistance to 1-beta-D-arabinofuranosylcytosine after high-dose treatment in childhood lymphoblastic leukemia: analysis of resistance mechanism in established cell lines.
Topics: Arabinofuranosylcytosine Triphosphate; Arabinofuranosyluracil; Child; Cytarabine; Drug Resistance; Humans; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Time Factors; Tumor Cells, Cultured | 1989 |
A study of the mechanisms of cytotoxicity of Ara-C on three human leukemic cell lines.
Topics: Arabinofuranosylcytosine Triphosphate; Cytarabine; Deoxycytidine Kinase; Deoxycytosine Nucleotides; DNA; DNA Ligases; DNA Polymerase II; DNA, Neoplasm; Humans; Leukemia; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Leukemia, Promyelocytic, Acute; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Tumor Cells, Cultured; Tumor Stem Cell Assay | 1989 |
Differential metabolism of 9-beta-D-arabinofuranosylguanine in human leukemic cells.
Topics: Arabinofuranosylcytosine Triphosphate; Arabinonucleosides; Arabinonucleotides; Cell Division; Cytarabine; Guanine; Humans; In Vitro Techniques; Leukemia; T-Lymphocytes; Tumor Cells, Cultured | 1989 |
Transport and metabolism of 1-beta-D-arabinofuranosylcytosine in human ovarian adenocarcinoma cells.
Topics: Adenocarcinoma; Aged; Arabinofuranosylcytosine Triphosphate; Binding Sites; Cell Line; Cytarabine; Female; Humans; Leukemia, Myelomonocytic, Acute; Male; Ovarian Neoplasms; Thioinosine | 1989 |
Increased sensitivity to 1-beta-D-arabinofuranosylcytosine in P388 murine leukemic cells resistant to etoposide.
Topics: Animals; Arabinofuranosylcytosine Triphosphate; Cell Line; Cytarabine; Deoxyribonucleotides; Drug Resistance; Etoposide; Leukemia P388; Leukemia, Experimental; Mice | 1989 |
Human cytomegalovirus-induced DNA polymerase and its interaction with the triphosphates of 1-(2'-deoxy-2'-fluoro-beta-D-arabinofuranosyl)-5-methyluracil, -5-iodocytosine, and -5-methylcytosine.
Topics: Antiviral Agents; Arabinofuranosylcytosine Triphosphate; Arabinofuranosyluracil; Arabinonucleotides; Cytarabine; Cytomegalovirus; DNA Replication; DNA-Directed DNA Polymerase; Enzyme Induction; Humans; Kinetics; Nucleic Acid Synthesis Inhibitors; Substrate Specificity; Virus Replication | 1985 |
Formation of cytosine arabinoside-5'-triphosphate in cultured human leukemic cell lines correlates with nucleoside transport capacity.
Topics: Arabinofuranosylcytosine Triphosphate; Arabinonucleotides; Biological Transport; Cell Line; Cell Membrane; Cytarabine; Humans; Leukemia | 1987 |
[Relation between plasma Ara-C and intracellular Ara-CTP levels by intermediate dose and high dose Ara-C administration in the treatment of AML].
Topics: Adult; Aged; Arabinofuranosylcytosine Triphosphate; Arabinonucleotides; Bone Marrow; Bone Marrow Cells; Cytarabine; Humans; Leukemia, Myeloid, Acute; Middle Aged | 1988 |
Modulation of arabinosylnucleoside metabolism by arabinosylnucleotides in human leukemia cells.
Topics: Arabinofuranosylcytosine Triphosphate; Arabinonucleotides; Cytarabine; Humans; Leukemia; Phosphorylation; Tumor Cells, Cultured; Vidarabine | 1988 |
Bromodeoxyuridine enhancement of 1-beta-D-arabinofuranosylcytosine metabolic activation and toxicity in HL-60 leukemic cells.
Topics: Arabinofuranosylcytosine Triphosphate; Biotransformation; Bromodeoxyuridine; Cell Cycle; Cell Survival; Cytarabine; Deoxycytosine Nucleotides; Deoxyguanine Nucleotides; DNA, Neoplasm; Humans; Phosphorylation; Tumor Cells, Cultured | 1988 |
Effects of 1-beta-D-arabinofuranosylcytosine incorporation on elongation of specific DNA sequences by DNA polymerase beta.
Topics: Arabinofuranosylcytosine Triphosphate; Base Sequence; Cytarabine; Deoxycytosine Nucleotides; DNA; DNA Polymerase I | 1988 |
Comparison of the cellular pharmacokinetics and toxicity of 2',2'-difluorodeoxycytidine and 1-beta-D-arabinofuranosylcytosine.
Topics: Animals; Arabinofuranosylcytosine Triphosphate; Cell Line; Cell Survival; Clone Cells; Cytarabine; Deoxycytidine; Deoxycytidine Kinase; DNA Replication; Drug Evaluation, Preclinical; Gemcitabine; Kinetics | 1988 |
Cellular pharmacology and optimal therapeutic concentrations of 1-beta-D-arabinofuranosylcytosine 5'-triphosphate in leukemic blasts during treatment of refractory leukemia with high-dose 1-beta-D-arabinofuranosylcytosine.
Topics: Acute Disease; Arabinofuranosylcytosine Triphosphate; Arabinonucleotides; Biotransformation; Chromatography, High Pressure Liquid; Cytarabine; Humans; Kinetics; Leukemia; Leukemia, Myeloid; Leukemia, Myeloid, Acute | 1986 |
Correlation of drug-perturbed marrow cell growth kinetics and intracellular 1-B-D-arabinofuranosylcytosine metabolism with clinical response in adult acute myelogenous leukemia.
Topics: Arabinofuranosylcytosine Triphosphate; Bone Marrow; Bone Marrow Cells; Cell Cycle; Cells, Cultured; Cytarabine; DNA, Neoplasm; Drug Resistance; Humans; Leukemia, Myeloid, Acute; Prognosis | 1987 |
Saturation of 1-beta-D-arabinofuranosylcytosine 5'-triphosphate accumulation in leukemia cells during high-dose 1-beta-D-arabinofuranosylcytosine therapy.
Topics: Arabinofuranosylcytosine Triphosphate; Arabinonucleotides; Blast Crisis; Cytarabine; Dose-Response Relationship, Drug; Drug Administration Schedule; Humans; Infusions, Intravenous; Leukemia; Leukemia, Myeloid; Leukemia, Myeloid, Acute; Metabolic Clearance Rate | 1987 |
Degradation of 1-beta-D-arabinofuranosylcytosine 5'-triphosphate in human leukemic myeloblasts and lymphoblasts.
Topics: Arabinofuranosylcytosine Triphosphate; Arabinonucleotides; Cytarabine; DCMP Deaminase; Guanosine; Half-Life; Humans; Kinetics; Leukemia, Lymphoid; Leukemia, Myeloid, Acute; Lymphocytes; Phosphorylation; Thioinosine; Thionucleosides | 1987 |
Pharmacologic studies of low-dose and high-dose continuous infusion cytosine arabinoside.
Topics: Adult; Aged; Arabinofuranosylcytosine Triphosphate; Arabinofuranosyluracil; Cytarabine; DNA Replication; Dose-Response Relationship, Drug; Female; Humans; Infusions, Intravenous; Leukemia, Myeloid, Acute; Male; Middle Aged; Replicon; Thrombocytopenia | 1987 |
An in vitro model to predict clinical response in adult acute myelogenous leukemia.
Topics: Adult; Arabinofuranosylcytosine Triphosphate; Blood; Bone Marrow; Cell Cycle; Cells, Cultured; Culture Media; Cytarabine; DNA, Neoplasm; Humans; In Vitro Techniques; Leukemia, Myeloid, Acute; Time Factors | 1987 |
Continuous infusion high-dose cytosine arabinoside without anthracyclines as induction and intensification therapy in adults under age 50 with newly diagnosed acute myelogenous leukemia.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Arabinofuranosylcytosine Triphosphate; Cytarabine; Daunorubicin; Dose-Response Relationship, Drug; Humans; Infusions, Intravenous; Leukemia, Myeloid, Acute; Mercaptopurine; Methotrexate; Prednisone; Time Factors; Translocation, Genetic; Vincristine | 1987 |
Comparison between the plasma and intracellular pharmacology of 1-beta-D-arabinofuranosylcytosine and 9-beta-D-arabinofuranosyl-2-fluoroadenine 5'-monophosphate in patients with relapsed leukemia.
Topics: Adult; Arabinofuranosylcytosine Triphosphate; Arabinonucleotides; Cytarabine; DNA Replication; Drug Evaluation; Female; Half-Life; Humans; Leukemia; Leukemia, Myeloid; Leukemia, Myeloid, Acute; Male; Middle Aged; Recurrence; Vidarabine | 1987 |
Biochemical pharmacology of high dose 1-beta-D-arabinofuranosylcytosine in childhood acute leukemia.
Topics: Arabinofuranosylcytosine Triphosphate; Child; Cytarabine; Half-Life; Humans; Leukemia; Leukemia, Lymphoid; Neutropenia | 1987 |
Regulation of 1-beta-D-arabinofuranosylcytosine 5'-triphosphate accumulation in human leukemia cells by deoxycytidine 5'-triphosphate.
Topics: Arabinofuranosylcytosine Triphosphate; Arabinonucleotides; Cell Cycle; Cell Line; Cytarabine; Deoxycytosine Nucleotides; Humans; Interphase; Leukemia; Nucleotides; Phosphorylation; T-Lymphocytes | 1986 |
Approaches to overcome in vivo anti-cancer drug resistance.
Topics: 3-Deazauridine; Animals; Antineoplastic Agents; Arabinofuranosylcytosine Triphosphate; Cell Line; Cytarabine; Doxorubicin; Drug Resistance; Drug Synergism; Fluorouracil; Leucovorin; Leukemia L1210; Liposomes; Mice; Verapamil | 1986 |
Cytosine arabinoside in the treatment of T-cell acute lymphoblastic leukemia.
Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Arabinofuranosylcytosine Triphosphate; Combined Modality Therapy; Cytarabine; Female; Humans; Leukemia, Lymphoid; Male; Nucleosides; T-Lymphocytes | 1987 |
Pharmacokinetic parameters of 1-beta-D-arabinofuranosylcytosine (ara-C) and their relationship to intracellular metabolism of ara-C, toxicity, and response of patients with acute nonlymphocytic leukemia treated with conventional and high-dose ara-C.
Topics: Acute Disease; Animals; Arabinofuranosylcytosine Triphosphate; Arabinofuranosyluracil; Cytarabine; Drug Administration Schedule; Humans; Leukemia; Leukemia L1210; Metabolic Clearance Rate; Mice; Uridine Kinase | 1987 |
Saturation of ara-CTP accumulation during high-dose ara-C therapy: pharmacologic rationale for intermediate-dose ara-C.
Topics: Arabinofuranosylcytosine Triphosphate; Arabinonucleotides; Cytarabine; Dose-Response Relationship, Drug; Drug Administration Schedule; Humans; Infusions, Intravenous; Leukemia; Metabolic Clearance Rate | 1987 |
ara-C in plasma and ara-CTP in leukemic cells after subcutaneous injection and continuous intravenous infusion of ara-C in patients with acute nonlymphoblastic leukemia.
Topics: Acute Disease; Adult; Aged; Arabinofuranosylcytosine Triphosphate; Arabinonucleotides; Cytarabine; Female; Humans; Infusions, Intravenous; Injections, Subcutaneous; Leukemia; Male; Metabolic Clearance Rate; Middle Aged | 1987 |
Studies of ara-C metabolism in acute leukemia.
Topics: Acute Disease; Arabinofuranosylcytosine Triphosphate; Bromodeoxyuridine; Cell Line; Cytarabine; DNA, Neoplasm; Dose-Response Relationship, Drug; Drug Resistance; Humans; Leukemia; Thymidine | 1987 |
Pharmacokinetics of the 5'-triphosphates of arabinosylcytosine and 2',2'-difluorodeoxycytidine in L1210 cells.
Topics: Animals; Arabinofuranosylcytosine Triphosphate; Arabinonucleotides; Biological Transport; Cytarabine; Cytidine Triphosphate; Cytosine Nucleotides; Leukemia L1210; Mice; Structure-Activity Relationship | 1987 |
Metabolism of ara-C by blast cells from patients with ANLL.
Topics: Acute Disease; Antineoplastic Combined Chemotherapy Protocols; Arabinofuranosylcytosine Triphosphate; Cytarabine; DNA, Neoplasm; Dose-Response Relationship, Drug; Drug Resistance; Female; Humans; Leukemia; Male; Middle Aged | 1986 |
Effect of m-AMSA on the cellular pharmacology of ara-CTP in human leukemic cells during therapy with high-dose ara-C.
Topics: Amsacrine; Arabinofuranosylcytosine Triphosphate; Arabinonucleotides; Cytarabine; Dose-Response Relationship, Drug; Humans; Leukemia; Metabolic Clearance Rate | 1986 |
Abrogation of the prognostic significance of low leukemic cell retention of cytosine arabinoside triphosphate by intensification of therapy and by alteration in the dose and schedule of administration of cytosine arabinoside.
Topics: Acute Disease; Antineoplastic Combined Chemotherapy Protocols; Arabinofuranosylcytosine Triphosphate; Bone Marrow; Cytarabine; Doxorubicin; Humans; Leukemia; Middle Aged; Neoplasm Proteins; Phosphorylation; Prognosis | 1987 |
Pharmacokinetics and cellular determinants of response to 1-beta-arabinofuranosylcytosine (ara-C).
Topics: Animals; Arabinofuranosylcytosine Triphosphate; Bone Marrow; Cytarabine; Dose-Response Relationship, Drug; Drug Resistance; Humans; Leukemia; Leukemia L1210; Leukemia, Lymphoid; Leukemia, Myeloid, Acute; Mice; Mice, Inbred DBA | 1985 |
Evolution of clinical studies with high-dose cytosine arabinoside at the M.D. Anderson Hospital.
Topics: Arabinofuranosylcytosine Triphosphate; Chromosome Aberrations; Cytarabine; Drug Evaluation; Drug Resistance; Half-Life; Humans; Leukemia; Leukemia, Lymphoid; Leukemia, Myeloid; Leukemia, Myeloid, Acute; Prognosis; Time Factors | 1985 |
Cytosine arabinoside transport and metabolism in acute leukemias and T cell lymphoblastic lymphoma.
Topics: Adolescent; Adult; Aged; Arabinofuranosylcytosine Triphosphate; Biological Transport, Active; Biotransformation; Child; Child, Preschool; Cytarabine; Humans; In Vitro Techniques; Leukemia; Leukemia, Lymphoid; Leukemia, Myeloid, Acute; Lymphoma, Non-Hodgkin; Middle Aged; T-Lymphocytes | 1985 |
Pharmacokinetics of 1-beta-D-arabinofuranosylcytosine 5'-triphosphate in leukemic cells after intravenous and subcutaneous administration of 1-beta-D-arabinofuranosylcytosine.
Topics: Aged; Arabinofuranosylcytosine Triphosphate; Arabinonucleotides; Cytarabine; Female; Humans; Injections, Intravenous; Injections, Subcutaneous; Kinetics; Leukemia; Male; Middle Aged; Phosphorylation | 1985 |
Pharmacologically directed ara-C therapy for refractory leukemia.
Topics: Arabinofuranosylcytosine Triphosphate; Arabinonucleotides; Cytarabine; DNA; Drug Resistance; Humans; Kinetics; Leukemia | 1985 |
The treatment of patients with acute nonlymphocytic leukemia in remission.
Topics: Antineoplastic Combined Chemotherapy Protocols; Arabinofuranosylcytosine Triphosphate; Cytarabine; Humans; Kinetics; Leukemia; Prognosis; Recurrence; Time Factors | 1985 |
Relationship between leukemic cell retention of cytosine arabinoside triphosphate and the duration of remission in patients with acute non-lymphocytic leukemia.
Topics: Acute Disease; Adult; Arabinofuranosylcytosine Triphosphate; Arabinonucleotides; Cytarabine; Female; Humans; Leukemia; Male; Middle Aged; Phosphorylation; Time Factors | 1985 |
Relationship of 1-beta-D-arabinofuranosylcytosine in plasma to 1-beta-D-arabinofuranosylcytosine 5'-triphosphate levels in leukemic cells during treatment with high-dose 1-beta-D-arabinofuranosylcytosine.
Topics: Arabinofuranosylcytosine Triphosphate; Arabinonucleotides; Cytarabine; Humans; Kinetics; Leukemia | 1985 |
Enhanced production of intracellular ara-CTP after sequential use of methotrexate and 1-beta-D-arabinofuranosylcytosine.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Arabinofuranosylcytosine Triphosphate; Arabinonucleotides; Cytarabine; Deoxycytosine Nucleotides; Drug Administration Schedule; Leukemia L1210; Male; Methotrexate; Mice; Mice, Inbred Strains | 1985 |
Effects of hydroxyurea and thymidine derivatives on the uptake and metabolism of deoxycytidine and arabinofuranosylcytosine in log phase and contact-inhibited human diploid fibroblasts.
Topics: Arabinofuranosylcytosine Triphosphate; Cells, Cultured; Cytarabine; Deamination; Deoxycytidine; Deoxyuracil Nucleotides; Fibroblasts; Humans; Hydroxyurea; Thymidine; Thymine Nucleotides; Tritium | 1985 |
Therapeutic effect of bromvinyldeoxyuridine and several nucleotides during experimental herpetic infection.
Topics: Animals; Antiviral Agents; Arabinofuranosylcytosine Triphosphate; Bromodeoxyuridine; Cyclic CMP; Cytarabine; Guinea Pigs; Herpesviridae Infections; Rabbits; Rats | 1984 |
Inhibition of hepatitis B virus deoxyribonucleic acid polymerase by the 5'-triphosphates of 9-beta-D-arabinofuranosyladenine and 1-beta-D-arabinofuranosylcytosine.
Topics: Arabinofuranosylcytosine Triphosphate; Arabinonucleotides; Cytarabine; Hepatitis B virus; Nucleic Acid Synthesis Inhibitors; Time Factors; Vidarabine; Vidarabine Phosphate | 1981 |
Biochemical and cytokinetic modulation of L1210 and HL-60 cells by hydroxyurea and effect on 1-beta-D-arabinofuranosylcytosine metabolism and cytotoxicity.
Topics: Animals; Arabinofuranosylcytosine Triphosphate; Cell Line; Cell Survival; Cytarabine; Cytidine Triphosphate; DNA; Humans; Hydroxyurea; Kinetics; Leukemia L1210; Leukemia, Myeloid; Mice; RNA | 1983 |
Modulation of 1-beta-D-arabinofuranosylcytosine metabolism and cytotoxicity in L1210 cells by fluoropyrimidine pretreatment.
Topics: Animals; Arabinofuranosylcytosine Triphosphate; Cell Line; Cell Survival; Clone Cells; Cytarabine; Deoxyribonucleotides; Deoxyuridine; Drug Interactions; Floxuridine; Fluorodeoxyuridylate; Fluorouracil; Leukemia L1210; Mice; Uridine | 1982 |
High-dose cytosine arabinoside in multiple myeloma.
Topics: Aged; Arabinofuranosylcytosine Triphosphate; Blood Cell Count; Bone Marrow; Bone Marrow Diseases; Cell Count; Cytarabine; Drug Administration Schedule; Drug Evaluation; Female; Humans; Interphase; Male; Middle Aged; Multiple Myeloma | 1984 |
Prediction of sensitivity to 1-beta-D-arabinofuranosylcytosine by the plateau level of its 5'-triphosphate in human lymphoblastic cell lines in vitro.
Topics: Arabinofuranosylcytosine Triphosphate; Arabinonucleotides; Burkitt Lymphoma; Cell Line; Cytarabine; DNA; Humans; Leukemia, Lymphoid | 1983 |
Relationships among Ara-CTP pools, formation of (Ara-C)DNA, and cytotoxicity of human leukemic cells.
Topics: Arabinofuranosylcytosine Triphosphate; Cell Survival; Cytarabine; DNA; Humans; Leukemia, Myeloid, Acute; Tumor Stem Cell Assay | 1984 |
Continuous infusion high-dose cytosine arabinoside in refractory childhood leukemia.
Topics: Acute Disease; Adolescent; Arabinofuranosylcytosine Triphosphate; Bone Marrow; Child; Child, Preschool; Cytarabine; Deoxycytosine Nucleotides; Drug Administration Schedule; Humans; Infusions, Parenteral; Kinetics; Leukemia; Leukemia, Lymphoid | 1984 |
Modulation of the cellular pharmacology and clinical toxicity of 1-beta-D-arabinofuranosylcytosine.
Topics: Arabinofuranosylcytosine Triphosphate; Cell Line; Cytarabine; Deoxyribonucleotides; DNA; Drug Therapy, Combination; Humans; Hydroxyurea; Leukemia; Ribonucleotide Reductases; Ribonucleotides; Thymidine | 1982 |
Variation in sensitivity of DNA synthesis to ara-C in acute myeloid leukaemia.
Topics: Arabinofuranosylcytosine Triphosphate; Bone Marrow; Cells, Cultured; Cytarabine; DNA, Neoplasm; Dose-Response Relationship, Drug; Humans; Leukemia, Myeloid, Acute | 1980 |
Quantitation of 1-beta-D-arabinofuranosylcytosine 5'-triphosphate in the leukemic cells from bone marrow and peripheral blood of patients receiving 1-beta-D-arabinofuranosylcytosine therapy.
Topics: Arabinofuranosylcytosine Triphosphate; Arabinonucleotides; Bone Marrow; Cytarabine; Humans; Leukemia, Myeloid, Acute; Lymphocytes | 1980 |
Simultaneous determination of 1-beta-D-arabinofuranosylcytosine 5'-triphosphate and 3-deazauridine 5'-triphosphate in human leukemia cells by high-performance liquid chromatography.
Topics: 3-Deazauridine; Arabinofuranosylcytosine Triphosphate; Arabinonucleotides; Cells, Cultured; Chromatography, High Pressure Liquid; Cytarabine; Cytidine Triphosphate; Humans; Leukemia; Leukemia, Lymphoid; Leukemia, Myeloid, Acute; Uracil Nucleotides; Uridine; Uridine Triphosphate | 1980 |
Cytosine arabinoside deamination in human leukaemic myeloblasts and resistance to cytosine arabinoside therapy.
Topics: Adult; Arabinofuranosylcytosine Triphosphate; Arabinofuranosyluracil; Bone Marrow; Cells, Cultured; Cytarabine; Deamination; DNA, Neoplasm; Dose-Response Relationship, Drug; Drug Resistance; Humans; Leukemia, Myeloid, Acute; Tetrahydrouridine | 1981 |
Effect of liposomally trapped antitumour drugs on a drug-resistant mouse lymphoma in vivo.
Topics: Animals; Antineoplastic Agents; Arabinofuranosylcytosine Triphosphate; Cell Survival; Cytarabine; Dose-Response Relationship, Drug; Drug Resistance; Liposomes; Lymphoma; Methotrexate; Mice; Mice, Inbred CBA; Neoplasms, Experimental | 1982 |
Liposomally trapped AraCTP to overcome AraC resistance in a murine lymphoma in vitro.
Topics: Animals; Arabinofuranosylcytosine Triphosphate; Arabinonucleotides; Cell Line; Cytarabine; DNA, Neoplasm; Dose-Response Relationship, Drug; Drug Resistance; Liposomes; Lymphoma; Mice; Neoplasms, Experimental; Thymidine | 1982 |
Role of dephosphorylation in accumulation of 1-beta-D-arabinofuranosylcytosine 5'-triphosphate in human lymphoblastic cell lines with reference to their drug sensitivity.
Topics: Arabinofuranosylcytosine Triphosphate; Arabinonucleotides; Cell Division; Cell Line; Cells, Cultured; Cytarabine; DNA, Neoplasm; Humans; Hydroxyurea; Leukemia; Lymphoma; Phosphorylation; Thymidine | 1982 |
Two simple high-performance liquid chromatographic methods for simultaneous determination of 2'-deoxycytidine 5'-triphosphate and cytosine arabinoside 5'-triphosphate concentrations in biological samples.
Topics: Arabinofuranosylcytosine Triphosphate; Arabinonucleotides; Bone Marrow; Child; Chromatography, High Pressure Liquid; Cytarabine; Deoxycytosine Nucleotides; Humans; Leukemia; Spectrophotometry, Ultraviolet | 1982 |
Relationship between plasma Ara-C and intracellular Ara-CTP pools under conditions of continuous infusion and high-dose Ara-C treatment.
Topics: Arabinofuranosylcytosine Triphosphate; Arabinonucleotides; Cytarabine; Dose-Response Relationship, Drug; Humans; Kinetics; Leukemia | 1982 |
Inability of liposome encapsulated 1-beta-D-arabinofuranosylcytosine nucleotides to overcome drug resistance in L1210 cells.
Topics: Animals; Arabinofuranosylcytosine Triphosphate; Arabinonucleotides; Cells, Cultured; Cytarabine; Cytidine Monophosphate; DNA, Neoplasm; Drug Resistance; Female; Leukemia L1210; Liposomes; Mice; Mice, Inbred DBA | 1981 |
Increase in the cytotoxicity of 1-beta-D-arabinofuranosylcytosine due to inhibition of degradation of its triphosphate by hydroxyurea in Burkitt's lymphoma cells.
Topics: Animals; Arabinofuranosylcytosine Triphosphate; Arabinonucleotides; Burkitt Lymphoma; Cattle; Cells, Cultured; Cytarabine; Humans; Hydroxyurea | 1981 |
Effect of thymidine on the toxicity, antitumor activity, and metabolism of 1-beta-D-arabinofuranosylcytosine in rats bearing a chemically induced colon carcinoma.
Topics: Animals; Arabinofuranosylcytosine Triphosphate; Biotransformation; Colonic Neoplasms; Cytarabine; Deoxycytidine; Drug Interactions; Drug Therapy, Combination; Female; Neoplasms, Experimental; Rats; Thymidine; Tissue Distribution | 1980 |
Enhancement of 1-beta-D-arabinofuranosylcytosine accumulation within L1210 cells and increased cytotoxicity following thymidine exposure.
Topics: Animals; Arabinofuranosylcytosine Triphosphate; Cytarabine; Deoxycytidine; Deoxyribonucleotides; DNA, Neoplasm; Leukemia L1210; Mice; RNA, Neoplasm; Thymidine; Time Factors | 1980 |
1-beta-D-arabinofuranosylcytosine nucleotide inhibition of sialic acid metabolism in WI-38 cells.
Topics: Arabinofuranosylcytosine Triphosphate; Arabinonucleotides; Cell Line; Cells, Cultured; Cytarabine; Cytidine Monophosphate; Cytosine Nucleotides; Humans; Sialic Acids; Sialyltransferases; Transferases | 1980 |
High-performance liquid chromatographic analysis of cytosine arabinoside and metabolites in biological samples.
Topics: Animals; Arabinofuranosylcytosine Triphosphate; Arabinofuranosyluracil; Chromatography, High Pressure Liquid; Cytarabine; Female; Mice; Neoplasms, Experimental | 1980 |
Biochemical and antitumor effects of the combination of thymidine and 1-beta-D-arabinofuranosylcytosine against leukemia L1210.
Topics: Animals; Arabinofuranosylcytosine Triphosphate; Aspartic Acid; Cells, Cultured; Cytarabine; Cytidine; Drug Therapy, Combination; Leukemia L1210; Mice; Phosphonoacetic Acid; Thymidine | 1981 |
Cellular pharmacology of N4-hexadecyl-1-beta-D-arabinofuranosylcytosine in the human leukemic cell lines K-562 and U-937.
Topics: Antimetabolites, Antineoplastic; Antineoplastic Agents; Arabinofuranosylcytosine Triphosphate; Cell Differentiation; Cytarabine; Dipyridamole; DNA; Drug Carriers; Drug Interactions; Half-Life; Humans; Leukemia; Liposomes; Tumor Cells, Cultured | 1995 |
Effect of hemopoietic growth factors G-CSF and pIXY 321 on the activity of high dose Ara-C in human myeloid leukemia cells.
Topics: Arabinofuranosylcytosine Triphosphate; Cytarabine; DNA Damage; Gene Expression; Granulocyte Colony-Stimulating Factor; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; Interleukin-3; Leukemia, Myeloid; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Proto-Oncogenes; Recombinant Fusion Proteins; Tumor Cells, Cultured | 1993 |
Enhancement of cytosine arabinoside cytotoxicity by granulocyte/macrophage colony-stimulating factor and granulocyte colony-stimulating factor in a human myeloblastic leukemia cell line.
Topics: Antineoplastic Combined Chemotherapy Protocols; Arabinofuranosylcytosine Triphosphate; Cell Division; Child; Cytarabine; DNA, Neoplasm; Drug Synergism; Granulocyte Colony-Stimulating Factor; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; Hydrogen-Ion Concentration; Leukemia, Myeloid, Acute; RNA, Neoplasm; Solubility; Subcellular Fractions; Tumor Cells, Cultured | 1993 |
Formation of cytosine arabinoside-5'-triphosphate in different cultured lymphoblastic leukaemic cells with reference to their drug sensitivity.
Topics: Arabinofuranosylcytosine Triphosphate; Child; Cytarabine; Dose-Response Relationship, Drug; Humans; Leukemia, Lymphoid; Time Factors; Tumor Cells, Cultured | 1995 |
Cellular pharmacology of a liposomal preparation of N4-hexadecyl-1-beta-D-arabinofuranosylcytosine, a lipophilic derivative of 1-beta-D-arabinofuranosylcytosine.
Topics: Animals; Antineoplastic Agents; Arabinofuranosylcytosine Triphosphate; Cytarabine; Deamination; DNA; DNA, Neoplasm; Drug Resistance; Humans; Kinetics; Leukemia, Promyelocytic, Acute; Liposomes; Mice; Microsomes, Liver; Tumor Cells, Cultured | 1995 |
Characterization of a multidrug resistant human erythroleukemia cell line (K562) exhibiting spontaneous resistance to 1-beta-D-arabinofuranosylcytosine.
Topics: Arabinofuranosylcytosine Triphosphate; Cytarabine; Deoxycytidine Kinase; DNA, Neoplasm; Drug Resistance, Multiple; Humans; Leukemia, Erythroblastic, Acute; Phenotype; Thymidine; Tritium; Tumor Cells, Cultured | 1995 |
Intracellular pharmacodynamic studies of the synergistic combination of 6-mercaptopurine and cytosine arabinoside in human leukemia cell lines.
Topics: Arabinofuranosylcytosine Triphosphate; Cell Division; Cell Survival; Cytarabine; Deoxycytidine Kinase; DNA, Neoplasm; Dose-Response Relationship, Drug; Drug Resistance; Drug Synergism; Humans; Kinetics; Leukemia; Mercaptopurine; Tumor Cells, Cultured | 1995 |
GM-CSF and asparaginase potentiate ara-C cytotoxicity in HL-60 cells.
Topics: Arabinofuranosylcytosine Triphosphate; Asparaginase; Cell Division; Cytarabine; DNA, Neoplasm; Drug Synergism; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; Leukemia, Promyelocytic, Acute; Neoplastic Stem Cells; S Phase; Tumor Cells, Cultured; Tumor Stem Cell Assay | 1995 |
Effect of DNA polymerase inhibitors on repair of gamma ray-induced DNA damage in proliferating (intact versus permeable) human fibroblasts: evidence for differences in the modes of action of aphidicolin and 1-beta-D-arabinofuranosylcytosine.
Topics: Aphidicolin; Arabinofuranosylcytosine Triphosphate; Cells, Cultured; Child; Cytarabine; DNA Repair; Drug Combinations; Fibroblasts; Humans; Nucleic Acid Synthesis Inhibitors; Saponins | 1994 |
Modulation of 1-[beta-D-arabinofuranosyl] cytosine-induced apoptosis in human myeloid leukemia cells by staurosporine and other pharmacological inhibitors of protein kinase C.
Topics: Alkaloids; Apoptosis; Arabinofuranosylcytosine Triphosphate; Cytarabine; DNA Damage; Drug Synergism; Gene Expression; Genes, jun; Humans; Leukemia, Promyelocytic, Acute; Protein Kinase C; Staurosporine; Tumor Cells, Cultured | 1994 |
Modulation of the effect of 1-beta-D-arabinofuranosylcytosine by 6-mercaptopurine in L1210 cells.
Topics: Animals; Arabinofuranosylcytosine Triphosphate; Biological Transport; Cytarabine; Cytidine Deaminase; DNA, Neoplasm; Drug Synergism; In Vitro Techniques; Leukemia L1210; Mercaptopurine; Mice; Tumor Cells, Cultured | 1994 |
Calculation of individual dosage regimen of cytosine arabinoside (ara-C) based on metabolite levels in leukemic cells.
Topics: Arabinofuranosylcytosine Triphosphate; Cytarabine; Dose-Response Relationship, Drug; Humans; Leukemia, Myeloid, Acute | 1994 |
Effect of granulocyte-macrophage colony-stimulating factor on the metabolism of arabinosylcytosine triphosphate in blasts during therapy of patients with chronic myelogenous leukemia.
Topics: Arabinofuranosylcytosine Triphosphate; Blast Crisis; Cytarabine; Deoxycytosine Nucleotides; Drug Therapy, Combination; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Tumor Cells, Cultured | 1994 |
Combination of fludarabine and arabinosylcytosine for treatment of chronic lymphocytic leukemia: clinical efficacy and modulation of arabinosylcytosine pharmacology.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Arabinofuranosylcytosine Triphosphate; Arabinonucleotides; Cytarabine; Drug Administration Schedule; Drug Synergism; Female; Humans; Leukemia, Lymphocytic, Chronic, B-Cell; Male; Middle Aged; Survival Analysis; Treatment Outcome; Vidarabine | 1994 |
Modulation of intracellular metabolism of cytosine arabinoside in acute myeloid leukemia by granulocyte-macrophage colony-stimulating factor.
Topics: Adolescent; Adult; Aged; Arabinofuranosylcytosine Triphosphate; Cytarabine; Deoxycytidine Kinase; DNA Polymerase II; DNA-Directed DNA Polymerase; DNA, Neoplasm; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; Leukemia, Myeloid, Acute; Middle Aged; S Phase; Thymidine Kinase; Tumor Cells, Cultured | 1994 |
Recombinant GM-CSF modulates the metabolism of cytosine arabinoside in leukemic cells in bone marrow.
Topics: Arabinofuranosylcytosine Triphosphate; Bone Marrow; Bone Marrow Cells; Cytarabine; Deoxycytosine Nucleotides; DNA, Neoplasm; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; Intracellular Fluid; Kinetics; Leukemia, Myeloid, Acute; Leukocytes, Mononuclear; Recombinant Proteins; S Phase; Tritium; Tumor Cells, Cultured | 1993 |
High-dose cytosine arabinoside in chronic lymphocytic leukemia: a clinical and pharmacologic analysis.
Topics: Aged; Arabinofuranosylcytosine Triphosphate; Cytarabine; Female; Humans; Leukemia, Lymphocytic, Chronic, B-Cell; Male; Middle Aged | 1993 |
Long-term outcome of patients with acute myelogenous leukemia: the role of maintenance therapy, consolidation therapy and the predictive value of two in vitro assays.
Topics: Arabinofuranosylcytosine Triphosphate; Cytarabine; Humans; In Vitro Techniques; Leukemia, Myeloid, Acute; Predictive Value of Tests; Prognosis; Recurrence; Remission Induction; Treatment Outcome; Tumor Stem Cell Assay | 1993 |
On the interaction between cytosine arabinoside and etoposide in vivo and in vitro.
Topics: Antineoplastic Combined Chemotherapy Protocols; Arabinofuranosylcytosine Triphosphate; Cytarabine; Drug Interactions; Etoposide; Humans; In Vitro Techniques; Kinetics; Leukemia, Myeloid, Acute; Phosphorylation | 1993 |
Treatment of relapsed or refractory AML with intermediate-dose arabinosylcytosine (ara-C): confirmation of the importance of ara-C triphosphate formation in mediating response to ara-C.
Topics: Adult; Aged; Arabinofuranosylcytosine Triphosphate; Clinical Protocols; Cytarabine; Dose-Response Relationship, Drug; Humans; Leukemia, Myeloid, Acute; Middle Aged; Recurrence; Remission Induction | 1993 |
Characterization of tumor cell heterogeneity of a murine leukemia cell line (L1210) in response to arabinosylcytosine: quantitation using a computerized image analysis system.
Topics: Animals; Arabinofuranosylcytosine Triphosphate; Cell Division; Cytarabine; Image Processing, Computer-Assisted; Kinetics; Leukemia L1210; Mice; Tumor Cells, Cultured | 1993 |
Enhanced metabolism of 1-beta-D-arabinofuranosylcytosine in Down syndrome cells: a contributing factor to the superior event free survival of Down syndrome children with acute myeloid leukemia.
Topics: Acute Disease; Adolescent; Antineoplastic Combined Chemotherapy Protocols; Arabinofuranosylcytosine Triphosphate; Cell Line, Transformed; Cells, Cultured; Child; Child, Preschool; Chromosomes, Human, Pair 21; Cystathionine beta-Synthase; Cytarabine; Deoxycytosine Nucleotides; Disease-Free Survival; Down Syndrome; Female; Herpesvirus 4, Human; Homocysteine; Humans; Infant; Infant, Newborn; Leukemia, Megakaryoblastic, Acute; Leukemia, Myeloid; Male; Methotrexate; Myelodysplastic Syndromes; Neoplastic Stem Cells; Remission, Spontaneous; Survival Rate | 1996 |
A new sensitive method for determination of intracellular 1-beta-D-arabinofuranosylcytosine 5'-triphosphate content in human materials in vivo.
Topics: Alkaline Phosphatase; Arabinofuranosylcytosine Triphosphate; Blast Crisis; Cell Line; Chromatography, High Pressure Liquid; Chromatography, Thin Layer; Cytarabine; Humans; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Leukemia, Myeloid, Acute; Myelodysplastic Syndromes; Radioimmunoassay; Sensitivity and Specificity; Tumor Cells, Cultured | 1996 |
Modulation of metabolism and cytotoxicity of cytosine arabinoside with N-(phosphon)-acetyl-L-aspartate in human leukemic blast cells and cell lines.
Topics: Antimetabolites, Antineoplastic; Arabinofuranosylcytosine Triphosphate; Aspartic Acid; Cytarabine; Cytidine Triphosphate; DNA, Neoplasm; Drug Screening Assays, Antitumor; HL-60 Cells; Humans; Leukemia; Phosphonoacetic Acid; Tumor Cells, Cultured; Uridine Triphosphate | 1996 |
A novel in vitro model system for studying the action of ara-C.
Topics: Antimetabolites, Antineoplastic; Arabinofuranosylcytosine Triphosphate; Chromatography, High Pressure Liquid; Cytarabine; DNA Replication; DNA, Neoplasm; DNA, Viral; HeLa Cells; Humans; Models, Biological; Simian virus 40 | 1996 |
Application of an in vitro system in the study of chemotherapeutic drug effects on DNA replication.
Topics: Antibiotics, Antineoplastic; Arabinofuranosylcytosine Triphosphate; Cytarabine; DNA Replication; Doxorubicin; HeLa Cells; Humans; Phosphorylation; Plasmids; Progesterone; Receptors, Progesterone | 1996 |
Optimizing therapy for acute myeloid leukemia based on differences in intracellular metabolism of cytosine arabinoside between leukemic blasts and normal mononuclear blood cells.
Topics: Acute Disease; Antimetabolites, Antineoplastic; Arabinofuranosylcytosine Triphosphate; Arabinofuranosyluracil; Cytarabine; Female; Humans; Leukemia, Myeloid; Leukocytes, Mononuclear; Male | 1996 |
Intracellular pharmacodynamics of ara-C and flowcytometric analysis of cell cycle progression in leukemia chemotherapy.
Topics: Animals; Antimetabolites, Antineoplastic; Apoptosis; Arabinofuranosylcytosine Triphosphate; Biotransformation; Cell Cycle; Cell Survival; Cytarabine; Daunorubicin; DNA, Neoplasm; Flow Cytometry; Granulocyte Colony-Stimulating Factor; Granulocyte-Macrophage Colony-Stimulating Factor; HL-60 Cells; Humans; Kinetics; Leukemia L1210; Mercaptopurine; Mice; Tumor Cells, Cultured | 1997 |
Apoptosis-resistant phenotype selected by alternating exposure to camptothecin and etoposide.
Topics: Antineoplastic Agents; Apoptosis; Arabinofuranosylcytosine Triphosphate; ATP Binding Cassette Transporter, Subfamily B, Member 1; bcl-X Protein; Calcimycin; Camptothecin; Clone Cells; Cycloheximide; Cytarabine; DNA Fragmentation; Drug Resistance, Neoplasm; Etoposide; HL-60 Cells; Humans; Hydroxyurea; Kinetics; Nucleosomes; Phenotype; Proto-Oncogene Proteins c-bcl-2; Ultraviolet Rays | 1997 |
The influence of 1-beta-D-arabinofuranosylcytosine on the metabolism of phosphatidylcholine in human leukemic HL 60 and Raji cells.
Topics: Antimetabolites, Antineoplastic; Arabinofuranosylcytosine Triphosphate; Cell Survival; Cytarabine; HL-60 Cells; Humans; Lysophosphatidylcholines; Phosphatidylcholines | 1997 |
Regulation of deoxycytidine kinase by deoxycytidine and deoxycytidine 5' triphosphate in whole leukemia and tumor cells.
Topics: Animals; Arabinofuranosylcytosine Triphosphate; CHO Cells; Cricetinae; Cytarabine; Deoxycytidine; Deoxycytidine Kinase; Deoxycytosine Nucleotides; HL-60 Cells; Homeostasis; Humans; Leukemia; Ribonucleotide Reductases; Tumor Cells, Cultured | 1998 |
Modulation of resistance to ara-C by bryostatin in fresh blast cells from patients with AML.
Topics: Acute Disease; Antineoplastic Agents; Arabinofuranosylcytosine Triphosphate; Bryostatins; Cell Death; Cytarabine; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Humans; Lactones; Leukemia, Myeloid; Leukocytes, Mononuclear; Macrolides; Tetrazolium Salts; Thiazoles | 1998 |
Accumulation of arabinosyluracil 5'-triphosphate during arabinosylcytosine therapy in circulating blasts of patients with acute myelogenous leukemia.
Topics: Antimetabolites, Antineoplastic; Arabinofuranosylcytosine Triphosphate; Cytarabine; Humans; Leukemia, Myeloid, Acute; Uridine Triphosphate | 1998 |
Minimum dose of fludarabine for the maximal modulation of 1-beta-D-arabinofuranosylcytosine triphosphate in human leukemia blasts during therapy.
Topics: Acute Disease; Adult; Aged; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Arabinofuranosylcytosine Triphosphate; Arabinonucleotides; Cytarabine; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Granulocyte Colony-Stimulating Factor; Humans; Infusions, Intravenous; Leukemia, Myeloid; Male; Middle Aged; Neoplastic Stem Cells; Phosphorylation; Time Factors; Vidarabine | 1997 |
Influence of fludarabine on pharmacokinetics and pharmacodynamics of cytarabine: implications for a continuous infusion schedule.
Topics: Antimetabolites, Antineoplastic; Arabinofuranosylcytosine Triphosphate; Cytarabine; Dose-Response Relationship, Drug; Drug Administration Schedule; Humans; Infusions, Intravenous; K562 Cells; Vidarabine | 1996 |
All-trans-retinoic acid increases cytosine arabinoside cytotoxicity in HL-60 human leukemia cells in spite of decreased cellular ara-CTP accumulation.
Topics: Analysis of Variance; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Arabinofuranosylcytosine Triphosphate; Cytarabine; DNA Fragmentation; Drug Resistance, Neoplasm; Electrophoresis, Agar Gel; Flow Cytometry; HL-60 Cells; Humans; Tretinoin; Tumor Cells, Cultured | 1999 |
Ara-C affects formation of cancer cell DNA synthesome replication intermediates.
Topics: Antigens, Polyomavirus Transforming; Antimetabolites, Antineoplastic; Arabinofuranosylcytosine Triphosphate; Breast Neoplasms; Cell Division; Cytarabine; DNA Polymerase I; DNA Polymerase III; DNA Replication; DNA, Neoplasm; Humans; Replicon; Tumor Cells, Cultured | 2000 |
Effects of gemcitabine and araC on in vitro DNA synthesis mediated by the human breast cell DNA synthesome.
Topics: Antigens, Polyomavirus Transforming; Antimetabolites, Antineoplastic; Arabinofuranosylcytosine Triphosphate; Breast Neoplasms; Cloning, Molecular; Cytarabine; Deoxycytidine; DNA Polymerase I; DNA Polymerase III; DNA, Neoplasm; Gemcitabine; Humans; Replicon; Tumor Cells, Cultured | 2000 |
Successful modulation of high-dose cytosine arabinoside metabolism in acute myeloid leukaemia by haematopoietic growth factors: no effect of ribonucleotide reductase inhibitors fludarabine and gemcitabine.
Topics: Arabinofuranosylcytosine Triphosphate; Cytarabine; Deoxycytidine; Deoxycytidine Kinase; Drug Administration Schedule; Enzyme Inhibitors; Gemcitabine; Granulocyte Colony-Stimulating Factor; Granulocyte-Macrophage Colony-Stimulating Factor; Hematopoietic Cell Growth Factors; Humans; Immunosuppressive Agents; Leukemia, Myeloid; Ribonucleotide Reductases; Vidarabine | 2000 |
Ara-C differentially affects multiprotein forms of human cell DNA polymerase.
Topics: Antimetabolites, Antineoplastic; Arabinofuranosylcytosine Triphosphate; Cytarabine; DNA; DNA Polymerase I; DNA Primase; DNA Repair; DNA Replication; DNA-Directed DNA Polymerase; HeLa Cells; Humans; Macromolecular Substances; Multienzyme Complexes; Multiprotein Complexes; Protein Isoforms; Tritium | 2000 |
Collateral sensitivity to gemcitabine (2',2'-difluorodeoxycytidine) and cytosine arabinoside of daunorubicin- and VM-26-resistant variants of human small cell lung cancer cell lines.
Topics: Adenosine Triphosphate; Antimetabolites, Antineoplastic; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Arabinofuranosylcytosine Triphosphate; Carcinoma, Small Cell; Cell Survival; Cytarabine; Cytidine Deaminase; Daunorubicin; Deoxycytidine; Deoxycytidine Kinase; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Drug Synergism; Gemcitabine; Guanosine Triphosphate; Humans; Lung Neoplasms; Nucleoside Deaminases; Teniposide; Thymidine Kinase; Tumor Cells, Cultured; Uridine Triphosphate | 2001 |
Monitoring of intracellular 1-beta-D-arabinofuranosylcytosine 5'-triphosphate in 1-beta-D-arabinofuranosylcytosine therapy at low and conventional doses.
Topics: Adult; Aged; Aged, 80 and over; Arabinofuranosylcytosine Triphosphate; Cytarabine; Female; Half-Life; Humans; Infusions, Intravenous; Injections, Subcutaneous; Kinetics; Leukemia, Myeloid, Acute; Male; Middle Aged | 2001 |
Close correlation of 1-beta-D-arabinofuranosylcytosine 5'-triphosphate, an intracellular active metabolite, to the therapeutic efficacy of N(4)-behenoyl-1-beta-D-arabinofuranosylcytosine therapy for acute myelogenous leukemia.
Topics: Acute Disease; Adult; Aged; Aged, 80 and over; Antimetabolites, Antineoplastic; Arabinofuranosylcytosine Triphosphate; Area Under Curve; Biotransformation; Cytarabine; Female; Humans; Infusions, Intravenous; Intracellular Fluid; Leukemia, Myeloid; Male; Middle Aged; Neoplastic Stem Cells; Prodrugs; Remission Induction; Sensitivity and Specificity; Treatment Outcome | 2001 |
Inhibition of mitochondrial permeability transition and release of cytochrome c by anti-apoptotic nucleoside analogues.
Topics: Adenine; Animals; Arabinofuranosylcytosine Triphosphate; Cytarabine; Cytochrome c Group; Drug Interactions; Enzyme Inhibitors; Ion Channels; Kinetin; Male; Mitochondria, Heart; Mitochondria, Liver; Mitochondrial Membrane Transport Proteins; Mitochondrial Permeability Transition Pore; Nucleic Acid Synthesis Inhibitors; Purines; Rats; Rats, Wistar | 2002 |
Trimidox, an inhibitor of ribonucleotide reductase, synergistically enhances the inhibition of colony formation by Ara-C in HL-60 human promyelocytic leukemia cells.
Topics: Apoptosis; Arabinofuranosylcytosine Triphosphate; Benzamidines; Cell Division; Cytarabine; DNA; Drug Screening Assays, Antitumor; Drug Synergism; Enzyme Inhibitors; HL-60 Cells; Humans; Leukemia, Promyelocytic, Acute; Nucleic Acid Synthesis Inhibitors; Ribonucleotide Reductases | 2002 |
Differential mRNA expression of Ara-C-metabolizing enzymes explains Ara-C sensitivity in MLL gene-rearranged infant acute lymphoblastic leukemia.
Topics: Arabinofuranosylcytosine Triphosphate; Cell Survival; Child; Child, Preschool; Cytarabine; DCMP Deaminase; Deoxycytidine Kinase; DNA-Binding Proteins; Drug Resistance, Neoplasm; Equilibrative Nucleoside Transporter 1; Female; Gene Expression; Gene Rearrangement; Histone-Lysine N-Methyltransferase; Humans; Infant; Male; Myeloid-Lymphoid Leukemia Protein; Oligonucleotide Array Sequence Analysis; Polymerase Chain Reaction; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Proto-Oncogenes; Pyrimidine Nucleotides; RNA, Messenger; Transcription Factors; Tumor Cells, Cultured | 2003 |
Enforced expression of the tumor suppressor p53 renders human leukemia cells (U937) more sensitive to 1-[beta-D-arabinofuranosyl]cytosine (ara-C)-induced apoptosis.
Topics: Antimetabolites, Antineoplastic; Apoptosis; Arabinofuranosylcytosine Triphosphate; Cytarabine; Genes, p53; Genes, Tumor Suppressor; Humans; Leukemia; U937 Cells | 2003 |
Sensitization of ara-C-resistant lymphoma cells by a pronucleotide analogue.
Topics: Antimetabolites, Antineoplastic; Arabinofuranosylcytosine Triphosphate; Cell Division; Chromatography, High Pressure Liquid; Cytarabine; Deoxycytidine; Deoxycytidine Kinase; Drug Resistance, Neoplasm; Gemcitabine; Humans; Lymphoma, Follicular; Nucleic Acid Synthesis Inhibitors; Prodrugs; Tumor Cells, Cultured | 2003 |
Biochemical modulation of Ara-C effects by amidox, an inhibitor of ribonucleotide reductase in HL-60 promyelocytic human leukemia cells.
Topics: Antimetabolites, Antineoplastic; Arabinofuranosylcytosine Triphosphate; Cell Division; Colony-Forming Units Assay; Cytarabine; Deoxyribonucleotides; Growth Inhibitors; HL-60 Cells; Humans; Oximes; Ribonucleotide Reductases | 2004 |
An in vitro model system that can differentiate the stages of DNA replication affected by anticancer agents.
Topics: Antineoplastic Agents; Arabinofuranosylcytosine Triphosphate; Camptothecin; Cytarabine; DNA Replication; DNA-Directed DNA Polymerase; DNA, Viral; Doxorubicin; Electrophoresis, Agar Gel; Humans; Multienzyme Complexes; Simian virus 40 | 2004 |
GATA1, cytidine deaminase, and the high cure rate of Down syndrome children with acute megakaryocytic leukemia.
Topics: Antimetabolites, Antineoplastic; Arabinofuranosylcytosine Triphosphate; Arabinofuranosyluracil; Blotting, Western; Child; Cytarabine; Cytidine Deaminase; DNA-Binding Proteins; Down Syndrome; Erythroid-Specific DNA-Binding Factors; GATA1 Transcription Factor; Humans; Leukemia, Megakaryoblastic, Acute; Polymerase Chain Reaction; Time Factors; Transcription Factors; Transcription, Genetic; Transcriptional Activation; Up-Regulation | 2005 |
Ara-C induces apoptosis in resting B-CLL cells independent on cell proliferation, but involving Ara-CTP formation and inhibition of RNA synthesis.
Topics: Apoptosis; Arabinofuranosylcytosine Triphosphate; Cell Proliferation; Cytarabine; Humans; Leukemia, Lymphocytic, Chronic, B-Cell; RNA | 2006 |
The mechanisms of Ara-C-induced apoptosis of resting B-chronic lymphocytic leukemia cells.
Topics: Apoptosis; Arabinofuranosylcytosine Triphosphate; Cell Proliferation; Cytarabine; Female; Humans; Leukemia, Lymphocytic, Chronic, B-Cell; Male; RNA | 2006 |
A new, simple method for quantifying gemcitabine triphosphate in cancer cells using isocratic high-performance liquid chromatography.
Topics: Antimetabolites, Antineoplastic; Arabinofuranosylcytosine Triphosphate; Chromatography, High Pressure Liquid; Cytarabine; Deoxycytidine; Gemcitabine; HL-60 Cells; Humans; Leukemia, Lymphocytic, Chronic, B-Cell; Sensitivity and Specificity | 2006 |
Pharmacology of intracellular cytosine-arabinoside-5'-triphosphate in malignant cells of pediatric patients with initial or relapsed leukemia and in normal lymphocytes.
Topics: Adolescent; Arabinofuranosylcytosine Triphosphate; Cell Line; Cell Line, Tumor; Child; Child, Preschool; Chromatography, High Pressure Liquid; Cytarabine; Half-Life; Humans; Infant; Inhibitory Concentration 50; Lymphocytes; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Recurrence | 2007 |
Fludarabine-mediated circumvention of cytarabine resistance is associated with fludarabine triphosphate accumulation in cytarabine-resistant leukemic cells.
Topics: Arabinofuranosylcytosine Triphosphate; Cytarabine; Drug Resistance, Neoplasm; Drug Synergism; HL-60 Cells; Humans; Leukemia, Myeloid, Acute; Vidarabine | 2007 |
The synergistic interaction of gemcitabine and cytosine arabinoside with the ribonucleotide reductase inhibitor triapine is schedule dependent.
Topics: Animals; Antimetabolites, Antineoplastic; Arabinofuranosylcytosine Triphosphate; Cytarabine; Deoxycytidine; DNA; Drug Synergism; Gemcitabine; Humans; Pyridines; Ribonucleotide Reductases; Thiosemicarbazones; Tumor Cells, Cultured | 2007 |
Polymeric nanogels containing the triphosphate form of cytotoxic nucleoside analogues show antitumor activity against breast and colorectal cancer cell lines.
Topics: Animals; Antineoplastic Agents; Arabinofuranosylcytosine Triphosphate; Breast Neoplasms; Cell Cycle; Cell Death; Cell Line, Tumor; Cell Proliferation; Chemistry, Pharmaceutical; Colorectal Neoplasms; Cytarabine; Deoxycytidine; Drug Carriers; Drug Screening Assays, Antitumor; Flow Cytometry; Gemcitabine; Humans; Mice; Nanogels; Nucleosides; Polyethylene Glycols; Polyethyleneimine; Polymers; Polyphosphates | 2008 |
Intracellular cytarabine triphosphate production correlates to deoxycytidine kinase/cytosolic 5'-nucleotidase II expression ratio in primary acute myeloid leukemia cells.
Topics: 5'-Nucleotidase; Arabinofuranosylcytosine Triphosphate; Cytarabine; Deoxycytidine Kinase; Drug Resistance, Neoplasm; Equilibrative Nucleoside Transporter 1; HL-60 Cells; Humans; Leukemia, Myeloid, Acute; Predictive Value of Tests; RNA, Messenger | 2009 |
Long term cultured HL-60 cells are intrinsically resistant to Ara-C through high CDA activity.
Topics: Arabinofuranosylcytosine Triphosphate; Arabinofuranosyluracil; Cytarabine; Cytidine Deaminase; Drug Resistance, Neoplasm; HL-60 Cells; Humans; RNA, Messenger; RNA, Neoplasm | 2012 |
A novel bioluminescent bacterial biosensor for measurement of Ara-CTP and cytarabine potentiation by fludarabine in seven leukaemic cell lines.
Topics: Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Arabinofuranosylcytosine Triphosphate; Bacterial Proteins; Biosensing Techniques; Cell Line, Tumor; Cytarabine; HL-60 Cells; Humans; K562 Cells; Leukemia; Luminescent Measurements; Luminescent Proteins; Treatment Outcome; Vidarabine | 2013 |
Investigation and verification of a bioluminescent biosensor for the quantitation of ara-CTP generation: a biomarker for cytosine arabinoside sensitivity in acute myeloid leukaemia.
Topics: Arabinofuranosylcytosine Triphosphate; Biomarkers, Tumor; Biosensing Techniques; Cytarabine; Humans; Leukemia, Myeloid, Acute; Limit of Detection; Luminescent Measurements | 2014 |
Simultaneous determination of 1-β-d-Arabinofuranosylcytosine and two metabolites, 1-β-d-Arabinofuranosyluracil and 1-β-d-Arabinofuranosylcytosine triphosphate in leukemic cell by HPLC-MS/MS and the application to cell pharmacokinetics.
Topics: Adult; Antimetabolites, Antineoplastic; Arabinofuranosylcytosine Triphosphate; Arabinofuranosyluracil; Cell Line, Tumor; Chromatography, High Pressure Liquid; Cytarabine; Humans; Limit of Detection; Middle Aged; Tandem Mass Spectrometry; Young Adult | 2014 |
Rapid in-vitro testing for chemotherapy sensitivity in leukaemia patients.
Topics: Antimetabolites, Antineoplastic; Arabinofuranosylcytosine Triphosphate; Biological Assay; Biosensing Techniques; Cell Line, Tumor; Cytarabine; Drug Screening Assays, Antitumor; Escherichia coli; Genes, Reporter; Genetic Engineering; Humans; Leukemia, Myeloid, Acute; Limit of Detection; Luciferases, Bacterial; Luminescent Measurements; Operon; Phosphorylation | 2014 |
Targeting SAMHD1 with the Vpx protein to improve cytarabine therapy for hematological malignancies.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Animals; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Arabinofuranosylcytosine Triphosphate; Child; Child, Preschool; Cytarabine; Disease Models, Animal; Female; Humans; In Vitro Techniques; Infant; Leukemia, Myeloid, Acute; Male; Mice; Molecular Targeted Therapy; Monomeric GTP-Binding Proteins; Prognosis; SAM Domain and HD Domain-Containing Protein 1; Viral Regulatory and Accessory Proteins | 2017 |
Ribonucleotide reductase inhibitors suppress SAMHD1 ara-CTPase activity enhancing cytarabine efficacy.
Topics: Animals; Arabinofuranosylcytosine Triphosphate; Cytarabine; Leukemia, Myeloid, Acute; Mice; Pyrophosphatases; Ribonucleotide Reductases; SAM Domain and HD Domain-Containing Protein 1 | 2020 |
Development and application of a rapid and sensitive liquid chromatography-mass spectrometry method for simultaneous analysis of cytarabine, cytarabine monophosphate, cytarabine diphosphate and cytarabine triphosphate in the cytosol and nucleus.
Topics: Arabinofuranosylcytosine Triphosphate; Chromatography, High Pressure Liquid; Cytarabine; Cytosol; Diphosphates; Humans; Tandem Mass Spectrometry | 2022 |
SAMHD1 single nucleotide polymorphisms impact outcome in children with newly diagnosed acute myeloid leukemia.
Topics: Arabinofuranosylcytosine Triphosphate; Child; Cytarabine; Humans; Leukemia, Myeloid, Acute; Polymorphism, Single Nucleotide; SAM Domain and HD Domain-Containing Protein 1 | 2023 |