cystine has been researched along with sulfasalazine in 21 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (4.76) | 18.2507 |
| 2000's | 4 (19.05) | 29.6817 |
| 2010's | 9 (42.86) | 24.3611 |
| 2020's | 7 (33.33) | 2.80 |
| Authors | Studies |
|---|---|
| Adler, G; Liptay, S; Schmid, RM; Wahl, C | 1 |
| Chung, WJ; Gillespie, GY; Gladson, CL; Hamza, H; Lyons, SA; Nelson, GM; Sontheimer, H | 1 |
| Buckley, AR; Cunha, GR; Cutz, JC; Doxsee, DW; Gout, PW; Karp, CM; Kurita, T; Lo, M; Wang, Y; Wang, YZ; Xue, H | 1 |
| Buckley, AR; Dockery, P; Gout, PW; Guan, J; Karp, CM; Lam, S; Lo, M; Mahon, S; Wang, YZ | 1 |
| Bernier, J; D'Elia, M; Dupras, C; Patenaude, J | 1 |
| Alvarado, O; Blower, PE; Gout, PW; Huang, Y; Pham, AN; Ravula, R | 1 |
| Alt, J; Ferraris, DV; Hin, N; Rojas, C; Sattler, R; Shukla, K; Slusher, BS; Thomas, AG; Tsukamoto, T | 1 |
| Baba, H; Furuhashi, S; Hirashima, K; Ishimoto, T; Kitagawa, Y; Masuko, T; Nagano, O; Oshima, H; Oshima, M; Saya, H; Seishima, R; Tsuchihashi, K; Wada, T; Wright, NA; Yoshikawa, M | 1 |
| Dodoo, E; Enger, PØ; Førde, HE; Heggdal, JI; Leiss, L; Netland, IA; Pedersen, PH; Selheim, F; Skeie, BS; Sleire, L; Wang, J | 1 |
| Hansen, H; Hashizume, Y; Loiacono, KA; Rojas, C; Sahni, V; Sattler, R; Slusher, BS; Tendyke, K; Thomas, AG | 1 |
| Abe, S; Akashi, K; Akiyama, T; Baba, E; Furnari, FB; Ishikawa, M; Iwasaki, Y; Masuko, T; Morikawa, T; Nagane, M; Nagano, O; Ohmura, M; Okazaki, S; Onishi, N; Sampetrean, O; Saya, H; Seishima, R; Shimizu, M; Suematsu, M; Takao, A; Tsuchihashi, K; Wakimoto, H; Yoshikawa, M | 1 |
| Jang, HJ; Kim, EH; Park, JY; Roh, JL; Shin, D | 1 |
| Kanai, E; Maruo, T; Nagane, M; Shibata, Y; Shimizu, T; Yamashita, T; Yoshioka, C | 1 |
| Cai, A; Chen, R; Chen, Z; Ganapathy, V; Kou, L; Sun, R; Xiao, S; Yao, Q; Zheng, H; Zheng, Y | 1 |
| Kim, D; Lee, J; Roh, JL; Shin, D; You, JH | 1 |
| Fang, B; Gan, B; Koppula, P; Lee, H; Lei, G; Li, W; Lim, EW; Liu, X; Metallo, CM; Olszewski, K; Poyurovsky, MV; Shi, J; You, MJ; Zhang, J; Zhang, X; Zhang, Y; Zhuang, L | 1 |
| Gan, B; Koppula, P; Zhuang, L | 1 |
| Gaitskell-Phillips, G; Gil, MC; Martín-Cano, FE; Masot, J; Ortega-Ferrusola, C; Ortiz-Rodríguez, JM; Peña, FJ; Redondo, E; Silva, A; Tapia, JA | 1 |
| Nagase, S; Ohta, T; Seino, M; Sendo, K | 1 |
| Adès, L; Alexe, G; Belloucif, Y; Benaksas, C; Berrou, J; Braun, T; Castelli, FA; Chat, L; Chauvel, C; Clappier, E; Dal Bello, R; de Thé, H; Dombret, H; Duchmann, M; Fenaille, F; Fenouille, N; Forget, A; Gardin, C; Huntly, BJ; Itzykson, R; Joudinaud, R; Laiguillon, MC; Ling, F; Lobry, C; Meduri, E; Pacchiardi, K; Pardieu, B; Pasanisi, J; Penneroux, J; Puissant, A; Raffoux, E; Sodaro, G; Stegmaier, K; Su, A; Vaganay, C; Vasseur, L; Wu, HC | 1 |
| Horikirizono, H; Itamoto, K; Itoh, H; Nakaichi, M; Nemoto, Y; Sunahara, H; Tani, K | 1 |
1 review(s) available for cystine and sulfasalazine
| Article | Year |
|---|---|
Cystine transporter SLC7A11/xCT in cancer: ferroptosis, nutrient dependency, and cancer therapy.
Topics: Amino Acid Transport System y+; Antineoplastic Agents; Cystine; DNA Methylation; Ferroptosis; Gene Expression Regulation, Neoplastic; Glucose; Glutamine; Glutathione; Histones; Humans; Molecular Targeted Therapy; Neoplasms; Piperazines; Signal Transduction; Sorafenib; Sulfasalazine | 2021 |
20 other study(ies) available for cystine and sulfasalazine
| Article | Year |
|---|---|
Sulfasalazine: a potent and specific inhibitor of nuclear factor kappa B.
Topics: Anti-Infective Agents; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Aspirin; Blotting, Western; Cells, Cultured; Colonic Diseases; Cystine; Epithelial Cells; Fluorescent Antibody Technique, Indirect; Humans; Immunosuppression Therapy; Lipopolysaccharides; Mesalamine; NF-kappa B; Phorbol Esters; Phosphorylation; Plasmids; Proline; Recombinant Proteins; Recombination, Genetic; Sulfapyridine; Sulfasalazine; Thiocarbamates; Transcription Factor AP-1; Transfection; Tumor Necrosis Factor-alpha | 1998 |
Inhibition of cystine uptake disrupts the growth of primary brain tumors.
Topics: Amino Acid Transport Systems; Animals; Apoptosis; Benzoates; Brain Neoplasms; Caspases; Cell Division; Cystine; DNA, Neoplasm; Glutathione; Glycine; Humans; Rats; Rats, Sprague-Dawley; Sulfasalazine; Time Factors; Tumor Cells, Cultured | 2005 |
Sulfasalazine-induced cystine starvation: potential use for prostate cancer therapy.
Topics: Amino Acid Transport System ASC; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Cystine; Dose-Response Relationship, Drug; Humans; Male; Mice; Mice, Inbred NOD; Mice, SCID; Prostatic Neoplasms; Reverse Transcriptase Polymerase Chain Reaction; Sulfasalazine; Xenograft Model Antitumor Assays | 2007 |
The xc- cystine/glutamate antiporter as a potential therapeutic target for small-cell lung cancer: use of sulfasalazine.
Topics: Amino Acid Transport System y+; Animals; Anti-Inflammatory Agents, Non-Steroidal; Biological Transport; Carcinoma, Small Cell; Cell Line, Tumor; Cystine; Drug Delivery Systems; Gene Expression Regulation, Neoplastic; Glutathione; Humans; Inhibitory Concentration 50; Lung Neoplasms; Male; Mice; Mice, Inbred NOD; Mice, SCID; Sodium Glutamate; Sulfasalazine; Xenograft Model Antitumor Assays | 2009 |
Burn injury induces the expression of cystine/glutamate transporter (x(c)(-)) in mouse T cells.
Topics: Amino Acid Transport System y+; Animals; Biological Transport, Active; Burns; Cell Proliferation; Cells, Cultured; Cystine; Fusion Regulatory Protein-1; Gene Expression Regulation; Interleukin-2 Receptor alpha Subunit; Male; Mice; Mice, Inbred C57BL; Oxidative Stress; Protein Binding; Spleen; Sulfasalazine; T-Lymphocytes | 2009 |
Pharmacogenomic approach reveals a role for the x(c)- cystine/glutamate antiporter in growth and celastrol resistance of glioma cell lines.
Topics: Amino Acid Transport System y+; Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cell Proliferation; Cystine; Drug Resistance, Neoplasm; Gene Expression Profiling; Glioma; Humans; Oligonucleotide Array Sequence Analysis; Pentacyclic Triterpenes; Pharmacogenetics; RNA, Small Interfering; Sulfasalazine; Triterpenes | 2010 |
Inhibition of xc⁻ transporter-mediated cystine uptake by sulfasalazine analogs.
Topics: Amino Acid Transport System X-AG; Antiporters; Cell Line; Cystine; Humans; Structure-Activity Relationship; Sulfasalazine | 2011 |
Functional role of CD44v-xCT system in the development of spasmolytic polypeptide-expressing metaplasia.
Topics: Adenocarcinoma; Amino Acid Transport System y+; Animals; Biomarkers, Tumor; Cell Transformation, Neoplastic; Cocarcinogenesis; Cystine; Disease Progression; Gastric Mucosa; Helicobacter Infections; Humans; Hyaluronan Receptors; Intercellular Signaling Peptides and Proteins; Metaplasia; Mice; Mice, Inbred C57BL; Mice, Transgenic; Neoplasm Proteins; Peptides; Precancerous Conditions; Protein Isoforms; Stomach Neoplasms; Sulfasalazine | 2013 |
Drug repurposing: sulfasalazine sensitizes gliomas to gamma knife radiosurgery by blocking cystine uptake through system Xc-, leading to glutathione depletion.
Topics: Amino Acid Transport System y+; Animals; Brain Neoplasms; Cell Line, Tumor; Cystine; DNA; Drug Repositioning; Glioblastoma; Glutathione; Humans; Radiation-Sensitizing Agents; Radiosurgery; Rats; Sulfasalazine; Xenograft Model Antitumor Assays | 2015 |
High-Throughput Assay Development for Cystine-Glutamate Antiporter (xc-) Highlights Faster Cystine Uptake than Glutamate Release in Glioma Cells.
Topics: Amino Acid Transport System y+; Benzoates; Brain Neoplasms; Cell Line, Tumor; Cystine; Databases, Chemical; Gene Expression Regulation, Neoplastic; Glioma; Glutamic Acid; Glycine; High-Throughput Screening Assays; Humans; Inhibitory Concentration 50; Models, Biological; RNA, Messenger; Sulfasalazine; Time Factors | 2015 |
The EGF Receptor Promotes the Malignant Potential of Glioma by Regulating Amino Acid Transport System xc(-).
Topics: Amino Acid Transport System y+; Animals; Antioxidants; Apoptosis; Brain Neoplasms; Cell Membrane; Cell Movement; Cell Proliferation; Cystine; ErbB Receptors; Gene Expression Regulation, Neoplastic; Glioma; Glutamic Acid; Humans; Mice; Mice, Inbred NOD; Mice, Nude; Mice, SCID; Reactive Oxygen Species; Sulfasalazine; Tumor Cells, Cultured; Xenograft Model Antitumor Assays | 2016 |
Induction of ferroptotic cell death for overcoming cisplatin resistance of head and neck cancer.
Topics: Amino Acid Transport System y+; Animals; Antineoplastic Agents; Cell Death; Cell Line, Tumor; Cisplatin; Cystine; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm; Glutamine; Glutathione; Head and Neck Neoplasms; Humans; Male; Mice, Inbred BALB C; Mice, Nude; Piperazines; Reactive Oxygen Species; RNA Interference; Sulfasalazine; Transfection; Xenograft Model Antitumor Assays | 2016 |
Sulfasalazine, an inhibitor of the cystine-glutamate antiporter, reduces DNA damage repair and enhances radiosensitivity in murine B16F10 melanoma.
Topics: Animals; Antiporters; Cell Cycle; Cell Survival; Comet Assay; Cystine; DNA Damage; DNA Repair; Female; Fibroblasts; Glutamic Acid; Hydrogen Peroxide; Melanoma, Experimental; Mice; Mice, Inbred C57BL; Oxidative Stress; Radiation Tolerance; Reactive Oxygen Species; RNA Interference; RNA, Small Interfering; Sulfasalazine; X-Rays | 2018 |
Ambidextrous Approach To Disrupt Redox Balance in Tumor Cells with Increased ROS Production and Decreased GSH Synthesis for Cancer Therapy.
Topics: Antineoplastic Agents; Cell Death; Cell Line, Tumor; Cell Proliferation; Cell Survival; Cysteine; Cystine; Glutathione; Humans; Nanoparticles; Neoplasms; Oxidation-Reduction; Oxidative Stress; Reactive Oxygen Species; Sulfasalazine; Zinc Oxide | 2019 |
Dihydrolipoamide dehydrogenase regulates cystine deprivation-induced ferroptosis in head and neck cancer.
Topics: Animals; Cell Line, Tumor; Cystine; Dihydrolipoamide Dehydrogenase; Drug Resistance, Neoplasm; Ferroptosis; Gene Silencing; Head and Neck Neoplasms; Humans; Lipid Peroxidation; Male; Membrane Potential, Mitochondrial; Mice; Neoplasm Transplantation; Reactive Oxygen Species; Sulfasalazine | 2020 |
Cystine transporter regulation of pentose phosphate pathway dependency and disulfide stress exposes a targetable metabolic vulnerability in cancer.
Topics: Amino Acid Transport System y+; Animals; Biological Transport; Carcinoma, Renal Cell; Cell Death; Cell Line, Tumor; Cystine; Disulfides; Gastrointestinal Agents; Gene Expression Regulation, Neoplastic; Glucose; Glucose Transporter Type 1; Glucose Transporter Type 3; Glucosephosphate Dehydrogenase; Humans; Kidney Neoplasms; Mice; Mice, Nude; Pentose Phosphate Pathway; Phosphogluconate Dehydrogenase; Pyrazoles; Quinolines; Stress, Physiological; Sulfasalazine; Survival Analysis; Xenograft Model Antitumor Assays | 2020 |
The SLC7A11: sperm mitochondrial function and non-canonical glutamate metabolism.
Topics: Amino Acid Transport System y+; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cystine; Glutamates; Glutathione; Horses; Male; Metabolome; Mitochondria; Oxidative Stress; Spermatozoa; Sulfasalazine | 2020 |
Impact of the glutathione synthesis pathway on sulfasalazine-treated endometrial cancer.
Topics: Amino Acid Transport System y+; Antioxidants; Antiporters; Carcinoma, Endometrioid; Cell Line, Tumor; Cisplatin; Cystathionine gamma-Lyase; Cysteine; Cystine; Female; Glutathione; Humans; Methionine; Reactive Oxygen Species; Sulfasalazine | 2022 |
Cystine uptake inhibition potentiates front-line therapies in acute myeloid leukemia.
Topics: Cell Line, Tumor; Cysteine; Cystine; Daunorubicin; Humans; Leukemia, Myeloid, Acute; Nuclear Proteins; Sulfasalazine | 2022 |
Sulfasalazine, a potent cystine-glutamate transporter inhibitor, enhances osteogenic differentiation of canine adipose-derived stem cells.
Topics: Amino Acid Transport System X-AG; Animals; Cell Differentiation; Cystine; Dogs; Glutathione; Osteogenesis; RNA, Messenger; Stem Cells; Sulfasalazine | 2023 |