cystine has been researched along with glutamic acid in 190 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 22 (11.58) | 18.7374 |
| 1990's | 43 (22.63) | 18.2507 |
| 2000's | 58 (30.53) | 29.6817 |
| 2010's | 45 (23.68) | 24.3611 |
| 2020's | 22 (11.58) | 2.80 |
| Authors | Studies |
|---|---|
| Daniel, V; Drings, P; Eck, HP; Fätkenheuer, G; Mertens, T; Näher, H; Petzoldt, D; Pohl, C; Rosokat, H; Schrappe, M | 1 |
| Kato, S; Kuo, CH; Mawatari, K; Negishi, K | 1 |
| Mann, DF; Patel, M; Van Winkle, LJ; Wasserlauf, HG | 1 |
| Fujimoto, S; Hashimoto, K; Hatayama, T; Horie, Y; Imahara, H; Inoue, E; Kitamura, T; Kuroda, S; Ohara, A; Wakatsuki, T | 1 |
| Albano, A; Brandi, G; Cantoni, O; Cattabeni, F; Giacomoni, P; Luzzi, L | 1 |
| Dröge, W; Eck, HP; Mihm, S | 2 |
| Bannai, S; Ishii, T; Miura, K; Nakayama, K; Sato, H; Sugita, Y; Yamada, K; Yamada, M | 1 |
| Dröge, W; Eck, HP; Gmünder, H | 1 |
| Bannai, S; Cho, Y | 1 |
| Berry, BW; Boland, LM; Dingledine, R; Hoch, DB | 1 |
| Gargano, AD; Imaki, H; Messing, JM; Rerecich, M; Rudelli, R; Sturman, JA | 1 |
| Coyle, JT; Miyamoto, M; Murphy, TH; Sastre, A; Schnaar, RL | 1 |
| Bussolati, O; Dall'Asta, V; Foà, PP; Franchi-Gazzola, R; Gazzola, GC; Guidotti, GG; Longo, N | 1 |
| Forster, S; Lloyd, JB | 1 |
| Askanazi, J; Elwyn, DH; Gil, KM; Gump, FE; Kinney, JM; Starker, PM | 1 |
| Bannai, S; Kasuga, H | 1 |
| Gray, PN; May, PC | 1 |
| Bannai, S | 2 |
| Bannai, S; Hishinuma, I; Ishii, T; Watanabe, H | 1 |
| Bowring, MA; Foreman, JW; Lee, J; McNamara, PD; Rea, C; Segal, S | 1 |
| Bannai, S; Watanabe, H | 1 |
| Bannai, S; Ishii, T | 2 |
| Deneke, SM; Fanburg, BL | 1 |
| Cho, ES; Sahyoun, N; Stegink, LD | 1 |
| Bannai, S; Kitamura, E | 2 |
| Aurich, H; Danew, P; Friedrich, E; Marquardt, I | 1 |
| Aurich, H; Danew, P; Farr, W; Friedrich, E; Haschen, RJ; Marquardt, I | 1 |
| Bannai, S; Takada, A | 1 |
| Shinagawa, S | 1 |
| Johnson, CG; Johnson, CL | 1 |
| Almahbobi, G; de Kretser, DM; Kim, YH; McFarlane, JR; Stanton, PG; Temple-Smith, PD | 1 |
| Bannai, S; Fujiwara, K; Sagara, J; Sato, H | 1 |
| Gritsuk, AI | 1 |
| Baraban, JM; Ratan, RR | 1 |
| Bockstette, M; Dröge, W; Mihm, S; Roth, S | 1 |
| Bannai, S; Miura, K; Sagara, J | 1 |
| Dröge, W; Eck, HP; Fischbach, T; Hartung, S; Kinscherf, R; Murthy, KK; Peterhans, E; Plesker, R; Rouse, S; Stahl-Hennig, C | 1 |
| Ishita, S; Kato, S; Mawatari, K; Sugawara, K | 1 |
| Belliveau, MJ; Oka, A; Rosenberg, PA; Volpe, JJ | 1 |
| Olszewski, J; Sparrow, CP | 1 |
| Benrabh, H; Lefauconnier, JM | 1 |
| Kato, S; Mawatari, K; Sugitani, K; Takadera, T; Yasui, Y | 1 |
| Bärtsch, P; Dröge, W; Edler, L; Fischbach, T; Friedmann, B; Hack, V; Kinscherf, R; Weiss, C | 1 |
| Dringen, R; Hamprecht, B; Kranich, O | 1 |
| Abbas, AK; Jardemark, K; Lehmann, A; Sandberg, M; Weber, SG | 1 |
| Boustani, MR; Fanburg, BL; Hertig, IA; Maloney, EK; White, AC | 1 |
| Duval, D; Froissard, P; Monrocq, H | 1 |
| Oliveira, CR; Pereira, CM | 1 |
| Flohé, L; Han, D; Handelman, G; Kobuchi, H; Marcocci, L; Packer, L; Roy, S; Sen, CK; Tritschler, HJ | 1 |
| Conejero, C; Dillon-Carter, O; Freed, WJ; Poltorak, M; Tornatore, C | 1 |
| Alam, Z; Coombes, N; Steventon, GB; Waring, RH; Williams, AC | 1 |
| Hoang, MV; Sansom, CE; Turner, AJ | 1 |
| Abcouwer, SF; Collins, CL; Souba, WW; Wasa, M | 1 |
| Li, Y; Maher, P; Schubert, D | 1 |
| Chambers, D; Dargusch, R; Davis, J; Maher, P; Sagara, Y; Schubert, D | 1 |
| Huster, D; Paasche, G; Reichenbach, A | 1 |
| Beers, K; Bottje, WG; Cawthon, D; Evenson, C; McNew, R; Wang, S | 1 |
| Attwell, D; Takahashi, M; Warr, O | 1 |
| Li, H; Marshall, ZM; Whorton, AR | 1 |
| Iguchi, H; Konishi, K; Nakagawa, T; Sunami, K; Takayama, M; Yamane, H | 1 |
| Rothstein, JD; Sontheimer, H; Ye, ZC | 1 |
| Flynn, J; McBean, GJ | 1 |
| Evert, BO; Klockgether, T; Kovar, KA; Rundfeldt, C; Schulz, JB; Seyfried, J; Wüllner, U | 1 |
| Buckley, BJ; Whorton, AR | 1 |
| Bridges, CC; Ganapathy, V; Huang, W; Kekuda, R; Mehta, P; Prasad, PD; Smith, SB; Wang, H | 1 |
| Bannai, S; Kuriyama-Matsumura, K; Okuno, S; Sato, H; Tamba, M | 1 |
| Iwata, S; Nakamura, H; Sasada, T; Takabayashi, A; Ueda, S; Ueno, M; Yodoi, J | 1 |
| Allen, JW; Aschner, M; Shanker, G | 1 |
| Murphy, TH; Shih, AY | 1 |
| Hosoya, K; Saeki, S; Terasaki, T | 1 |
| Abdulrazzaq, YM; Ibrahim, A | 1 |
| Beitz, AJ; Chase, LA; Koerner, JF; Roon, RJ; Wellman, L | 1 |
| Piasecki, D; Schubert, D | 1 |
| Clayette, P; Dormont, D; Gras, G; Mialocq, P; Rimaniol, AC | 1 |
| Antolín, I; Herrera, F; Martín, V; Mayo, JC; Rodriguez, C; Sainz, RM | 1 |
| Bluvshtein, E; Komlosh, A; Oesch, F; Porat, N; Stark, AA; Steinberg, P; Tuby, C; Volohonsky, G | 2 |
| Doi, M; Kubo, Y; Kudo, A; Ogasawara, K; Ogawa, A; Sugawara, A; Suzuki, M; Suzuki, T; Yoshida, K | 1 |
| Endou, H; Hosoya, K; Kanai, Y; Naito, M; Ohtsuki, S; Saeki, S; Takanaga, H; Terasaki, T; Tomi, M; Tsuruo, T | 1 |
| Dargusch, R; Schubert, D | 1 |
| Baker, DA; Kalivas, PW; Shen, H | 1 |
| Baker, DA; Kalivas, PW; Ramamoorthy, S; Samuvel, DJ; Shen, H; Xi, ZX | 1 |
| Bannai, S; Kimata, M; Sakamoto, K; Sato, H; Tamba, M; Wang, H | 1 |
| Baker, DA; Kalivas, PW; Lake, RW; McFarland, K; Shen, H; Tang, XC; Toda, S | 1 |
| Abukawa, H; Funaki, T; Hosoya, K; Katayama, K; Kondo, T; Obinata, M; Ohtsuki, S; Terasaki, T; Tomi, M; Ueda, M | 1 |
| Berfield, JL; Chen, N; Reith, ME; Rickey, J | 1 |
| Bridges, RJ; Patel, SA; Rhoderick, JF; Warren, BA | 1 |
| Britton, J; Broadfield, E; Fogarty, A; Lawson, N; Lewis, S | 1 |
| Bordey, A; Huang, H | 1 |
| Bates, TE; Rosin, C; Skaper, SD | 1 |
| Bridges, RJ; Nunn, PB; Patel, SA; Warren, BA | 1 |
| Bannai, S; Maebara, K; Nomura, S; Sato, H; Sato, K; Tamba, M | 1 |
| Hayes, D; McBean, GJ; Rauen, T; Wiessner, M | 1 |
| Bukowska, B | 1 |
| Kalivas, PW; McFarland, K; Melendez, RI; Moran, MM; Seamans, JK | 1 |
| Bridges, CC; Zalups, RK | 1 |
| Dickinson, DA; Fando, JL; Forman, HJ; Martín del Río, R; Martín, ME; Muñoz, FM; Salinas, M | 1 |
| Arakawa, M; Ishige, K; Ito, Y; Saito, H; Tanaka, M | 1 |
| Hinoi, E; Nakamichi, N; Takemori, A; Wang, L; Yoneda, Y | 1 |
| Erb, H; Kalivas, PW; Murphy, TH; Shih, AY; Sun, X; Toda, S | 1 |
| Hinoi, E; Inoue, M; Murafuji, Y; Takarada, T; Uno, K; Yoneda, Y | 1 |
| La Bella, V; Piccoli, F; Piccoli, T; Valentino, F | 1 |
| Domercq, M; Etxebarria, E; Fern, R; Matute, C; Sánchez-Gómez, MV; Sherwin, C | 1 |
| Hinoi, E; Iemata, M; Takarada, T; Taniura, H; Yoneda, Y | 1 |
| Adeyeye, EI; Aluko, AO; Asaolu, SS | 1 |
| Banjac, A; Bannai, S; Bornkamm, GW; Conrad, M; Daniel, PT; Issels, RD; Kölle, P; Perisic, T; Sato, H; Seiler, A; Tschoep, K; Weiss, N | 1 |
| Donaldson, PJ; Jacobs, MD; Kistler, J; Li, L; Lim, J | 1 |
| Akiyama, Y; Arisaka, H; Kurihara, S; Shibahara, S | 1 |
| Gout, PW; Lo, M; Wang, YZ | 1 |
| Sontheimer, H | 1 |
| Abdulhameed, O; Baker, DA; Grier, MD; Kau, KS; Madayag, A; Mantsch, JR | 1 |
| Steketee, JD; Xie, X | 1 |
| Lewerenz, J; Lozano, C; Maher, P; Torres, JL | 1 |
| Banerjee, R; Garg, SK; Vitvitsky, V | 1 |
| Kalivas, PW; Mohan, A; Nair, SS; Pendyam, S | 1 |
| Liu, X; Lobner, D; Rush, T; Zapata, J | 1 |
| Eyüpoglu, IY; Hahnen, E; Savaskan, NE | 1 |
| Kalivas, PW; Knackstedt, LA; Melendez, RI | 1 |
| Lobner, D | 1 |
| Jiang, ZL; Liang, AH; Liang, YY; Liu, QY | 1 |
| Albrecht, P; Dittmer, S; Lewerenz, J; Maher, P; Methner, A; Noack, R | 1 |
| Bamann, C; Bamberg, E; Gossing, M; Heberle, J; Nack, M; Radu, I; von Mollard, GF | 1 |
| Dargusch, R; Lewerenz, J; Maher, P | 1 |
| Lobner, D; Seidler, FJ; Slotkin, TA | 1 |
| Hori, O; Nakamura, Y; Nakatani, E; Takarada, T; Takarada-Iemata, M; Yoneda, Y | 1 |
| Aw, TY; Circu, ML; D'Angelo, JA; Dehlink, E; Dickinson, BL; Dwyer, P; Fiebiger, E; Garay, J; Platzer, B | 1 |
| Eyüpoglu, IY; Hahnen, E; Hauke, J; Savaskan, NE; Seufert, S; Tränkle, C | 1 |
| Bannai, S; Beck, H; Conrad, M; De Bundel, D; Fernando, R; Kim, SW; Kobayashi, S; Massie, A; Michotte, Y; Plesnila, N; Sato, H; Schallier, A; Smolders, I; Vermoesen, K | 1 |
| Fujita, H; Hinoi, E; Nakamura, Y; Takarada, T; Uno, K; Yoneda, Y | 1 |
| Conrad, M; Sato, H | 1 |
| Bridges, RJ; Natale, NR; Patel, SA | 1 |
| Bridges, RJ; Patel, SA; Seib, TM | 1 |
| Domercq, M; Matute, C; Pampliega, O; Rodríguez-Antigüedad, A; Soria, FN; Villoslada, P | 1 |
| Fritz, K; Furey, A; Lobner, D; Pauly, K | 1 |
| Fukushima, K; Inoue, J; Kakazu, E; Kimura, O; Kondo, Y; Ninomiya, M; Shimosegawa, T; Tamai, K; Ueno, Y; Wakui, Y | 1 |
| Ankeny, DP; Banerjee, R; Garg, SK; Guan, Z; Kigerl, KA; Lai, W; McTigue, DM; Popovich, PG; Wei, P | 1 |
| Kalivas, BC; Kalivas, PW; Kolokithas, R; Kupchik, YM; Moussawi, K; Ogburn, KB; Tang, XC; Wang, X | 1 |
| Ganapathy, V; Gout, PW; Hewett, SJ; Huang, Y; Kalivas, PW; Lambros, M; Lewerenz, J; Maher, P; Massie, A; Methner, A; Pergande, M; Smith, SB; Smolders, I | 1 |
| D'Angelo, JA; Dickinson, BL; Fiebiger, E; Mattox, ML | 1 |
| Baker, DA; Bridges, R; Lobner, D; Lutgen, V | 1 |
| Braden, MR; Bridges, RJ; Matti, AA; Mirzaei, J; Natale, NR; Newell, JL; Patel, SA; Rudolph, J; Smith, SA | 1 |
| Ichihara, N; Kanemaki, N; Maruo, T; Ochiai, H; Onda, K; Sato, R | 1 |
| Albano, R; Liu, X; Lobner, D | 1 |
| Dixon, SJ; Gleason, CE; Hayano, M; Lee, ED; Patel, DN; Skouta, R; Slusher, BS; Stockwell, BR; Tatonetti, NP; Thomas, AG; Welsch, M | 1 |
| Gardner, LB; Martin, L | 1 |
| Mao, QX; Yang, TD | 1 |
| Gunning, P; Haftchenary, S; Linher-Melville, K; Singh, G | 1 |
| Corn, CK; Hayano, M; Pagano, NC; Stockwell, BR; Yang, WS | 1 |
| Hansen, H; Hashizume, Y; Loiacono, KA; Rojas, C; Sahni, V; Sattler, R; Slusher, BS; Tendyke, K; Thomas, AG | 1 |
| Accart, N; Arigoni, M; Aurisicchio, L; Barrera, G; Bolli, E; Calogero, RA; Cavallo, F; Conti, L; Lanzardo, S; Macagno, M; Pizzimenti, S; Rooke, R; Ruiu, R | 1 |
| Albano, R; Baker, DA; Choi, S; Kong, L; Lobner, D; Madayag, A; Mantsch, JR; Raddatz, N | 1 |
| Alam, M; Hasegawa, M; Hiraki, M; Kufe, D; Maeda, T; Rajabi, H; Sukhatme, VP; Suzuki, Y; Tagde, A; Takahashi, H; Yin, L | 1 |
| Abe, S; Akashi, K; Akiyama, T; Baba, E; Furnari, FB; Ishikawa, M; Iwasaki, Y; Masuko, T; Morikawa, T; Nagane, M; Nagano, O; Ohmura, M; Okazaki, S; Onishi, N; Sampetrean, O; Saya, H; Seishima, R; Shimizu, M; Suematsu, M; Takao, A; Tsuchihashi, K; Wakimoto, H; Yoshikawa, M | 1 |
| Gera, R; Ghosh, D; Kushwaha, R; Patnaik, S; Sharma, AK; Singh, V | 1 |
| Castelán, F; Chi-Castañeda, D; Guillem, AM; Hernández-Kelly, LC; Martínez-Lozada, Z; Méndez-Flores, OG; Najimi, M; Olivares-Bañuelos, TN; Ortega, A; Suárez-Pozos, E | 1 |
| Carelli, V; Chan, DC; D'Aurelio, M; Jain, M; Mishra, P; Shin, CS; Watrous, JD | 1 |
| Asara, JM; Geck, RC; Ghisolfi, L; Lien, EC; Toker, A | 1 |
| Kanai, E; Maruo, T; Nagane, M; Shibata, Y; Shimizu, T; Yamashita, T; Yoshioka, C | 1 |
| Chen, KY; Diehl, AM; Shen, X | 1 |
| Acuña, L; Chehín, R; Del-Bel, E; Dos-Santos-Pereira, M; González-Lizárraga, F; Hamadat, S; Michel, PP; Raisman-Vozari, R; Rocca, J; Sepulveda-Diaz, J | 1 |
| Katoh, H; Teramoto, K | 1 |
| Sáenz, JB | 1 |
| Anirudh, CR; Sharma, M | 1 |
| Cormerais, Y; Pouysségur, J; Vucetic, M | 1 |
| Bowles, C; Chase, LA; Engelsman, SB; Flores, G; King, AG; Robinson, AE; Rothstein, J; Schiller, N; Smith, SL; VerHeulen Kleyn, M | 1 |
| Delfarah, A; Graham, NA; Joly, JH; Parrish, S; Phung, PS | 1 |
| Ashraf, A; Jeandriens, J; Parkes, HG; So, PW | 1 |
| Arckens, L; Bentea, E; Churchill, MJ; De Pauw, L; Declerck, NB; DePasquale, EAK; Funk, AJ; Hermans, E; Janssen, P; Lara, O; Massie, A; McCullumsmith, RE; Meshul, CK; Moore, C; O'Donovan, SM; Ris, L; Sato, H; Verbruggen, L; Villers, A | 1 |
| Amaral, VCS; Laverde, CF; Marin, MT; Morais-Silva, G | 1 |
| Gudbrandsen, OA; Rønnevik, AK | 1 |
| Deng, J; Guo, W; Hu, M; Jing, B; Kuang, Y; Li, K; Li, Q; Liao, Y; Lin, SH; Ling, J; Liu, S; Song, H; Sun, B; Tong, L; Wang, Q; Wang, T; Wu, Y; Xu, D; Yao, F; Yin, H; Zhou, BP | 1 |
| Bucci, D; Galeati, G; Mari, G; Mislei, B; Nerozzi, C; Ortiz-Rodriguez, JM; Peña, FJ; Spinaci, M; Tamanini, C | 1 |
| De Swert, K; Gilloteaux, J; Janssen, P; Massie, A; Nicaise, C; Rooman, I; Sprimont, L; Van Bulck, M | 1 |
| Donaldson, PJ; Li, B; Lim, JC; Martis, RM | 1 |
| Hung, CC; Lane, HY; Lin, CH | 1 |
| Biggin, PC; Deme, JC; Kolokouris, D; Kuteyi, G; Lea, SM; Newstead, S; Parker, JL | 1 |
| Itahana, K; Itahana, Y; Lee, Y; Ong, CC | 1 |
| Chen, K; He, J; Wang, J; Wang, X; Zhang, M | 1 |
| Germán-Acacio, JM; Gómez-Martín, D; Maravillas-Montero, JL; Mejía-Domínguez, NR; Páez-Franco, JC; Pérez-Fragoso, A; Ponce-de-León, A; Tamez-Torres, KM; Torres-Ruiz, J; Ulloa-Aguirre, A | 1 |
| Chen, L; Chen, P; Guo, H; Han, Z; He, Y; Hu, X; Li, Q; Liu, D; Liu, W; Luo, Y; Qi, L; Wu, Q; Zhang, X; Zhu, X | 1 |
| Acosta, ML; Black, J; Donaldson, PJ; Ji, LCL; Knight, LJ; Lim, JC; Martis, RM; Ng, R | 1 |
| Dahlmanns, JK; Dahlmanns, M; Savaskan, N; Steiner, HH; Yakubov, E | 1 |
| Böni-Schnetzler, M; de Baat, A; Donath, MY; Fontana, A; Meier, DT; Rachid, L | 1 |
| Aboushousha, R; Erickson, C; Hamilton, N; Janssen-Heininger, YMW; Li, J; MacPherson, M; Peng, Z; Reynaert, NL; Seward, DJ; van der Velden, J; White, S; Wouters, EFM | 1 |
| Böni-Schnetzler, M; de Baat, A; Donath, MY; Fontana, A; Meier, DT | 1 |
| Barger, SW; Gajewski, MP | 1 |
15 review(s) available for cystine and glutamic acid
| Article | Year |
|---|---|
HIV-induced cysteine deficiency and T-cell dysfunction--a rationale for treatment with N-acetylcysteine.
Topics: Acetylcysteine; Cysteine; Cystine; Glutamates; Glutamic Acid; Glutathione; HIV; HIV Infections; Humans; Hydrogen Peroxide; Oxidation-Reduction; Oxygen; Palliative Care; Superoxides; T-Lymphocytes | 1992 |
Apoptotic death in an in vitro model of neuronal oxidative stress.
Topics: Apoptosis; Cells, Cultured; Central Nervous System Diseases; Cystine; Free Radicals; Glutamic Acid; Glutathione; Humans; Neurons; Oxidative Stress; Reactive Oxygen Species | 1995 |
[Glutathione: its biosynthesis, induction agents and concentrations in selected diseases].
Topics: Animals; Cysteine; Cystine; Glutamic Acid; Glutathione; Glycine; Humans; Male; Neoplasms | 2004 |
The x(c)- cystine/glutamate antiporter: a potential target for therapy of cancer and other diseases.
Topics: Amino Acid Transport Systems; Animals; Antiporters; Cystine; Glutamic Acid; Humans; Neoplasms | 2008 |
A role for glutamate in growth and invasion of primary brain tumors.
Topics: Amino Acid Transport System X-AG; Animals; Antineoplastic Agents; Brain Neoplasms; Cystine; Glioma; Glutamic Acid; Humans; Neoplasm Invasiveness | 2008 |
The undertow of sulfur metabolism on glutamatergic neurotransmission.
Topics: Animals; Astrocytes; Brain; Cystine; Glutamic Acid; Glutathione; Humans; Models, Neurological; Neurons; Sulfur; Synaptic Transmission; Taurine | 2008 |
Mechanisms of beta-N-methylamino-L-alanine induced neurotoxicity.
Topics: Amino Acids, Diamino; Animals; Cell Death; Cyanobacteria Toxins; Cystine; Excitatory Amino Acid Agonists; Glutamic Acid; Humans; Neurotoxicity Syndromes; Neurotoxins; Oxidative Stress; Receptors, Glutamate | 2009 |
Mechanisms of oxidative glutamate toxicity: the glutamate/cystine antiporter system xc- as a neuroprotective drug target.
Topics: Amino Acid Transport System y+; Animals; Cell Death; Cystine; Drug Delivery Systems; Glutamic Acid; Humans; Mice; Neurons; Neuroprotective Agents; Oxidative Stress; Signal Transduction | 2010 |
The oxidative stress-inducible cystine/glutamate antiporter, system x (c) (-) : cystine supplier and beyond.
Topics: Amino Acid Transport System y+; Animals; Antiporters; Cystine; Glutamic Acid; Humans; Oxidative Stress | 2012 |
The cystine/glutamate antiporter system x(c)(-) in health and disease: from molecular mechanisms to novel therapeutic opportunities.
Topics: Amino Acid Transport Systems; Animals; Cystine; Glutamic Acid; Humans; Oxidation-Reduction; Phylogeny | 2013 |
Thinking outside the cleft to understand synaptic activity: contribution of the cystine-glutamate antiporter (System xc-) to normal and pathological glutamatergic signaling.
Topics: Amino Acid Transport System y+; Animals; Biological Transport; Central Nervous System; Cystine; Glutamic Acid; Glutathione; Humans; Mental Disorders; Neurodegenerative Diseases; Neurotoxicity Syndromes; Signal Transduction; Synapses | 2012 |
Targeting amino acids transporters (SLCs) to starve cancer cells to death.
Topics: Amino Acid Transport System ASC; Amino Acid Transport Systems; Amino Acids; Antioxidants; Cell Line, Tumor; Cystine; Gene Expression Regulation; Glutamic Acid; Humans; Large Neutral Amino Acid-Transporter 1; Metabolome; Minor Histocompatibility Antigens; Molecular Targeted Therapy; Neoplasms | 2019 |
Cystine/Glutamate Antiporter in Schizophrenia: From Molecular Mechanism to Novel Biomarker and Treatment.
Topics: Animals; Antiporters; Biological Transport; Biomarkers; Cystine; Disease Management; Disease Susceptibility; Glutamic Acid; Humans; Neurons; Neurotransmitter Agents; Oxidative Stress; Precision Medicine; Schizophrenia; Synaptic Transmission | 2021 |
The amino acid transporter SLC7A11-mediated crosstalk implicated in cancer therapy and the tumor microenvironment.
Topics: Amino Acid Transport System y+; Cell Line, Tumor; Cystine; Doxorubicin; Glutamic Acid; Humans; Neoplasms; Tumor Microenvironment | 2022 |
Glial Glutamate Transporter-Mediated Plasticity: System x
Topics: Alzheimer Disease; Amino Acid Transport System X-AG; Amino Acid Transport System y+; Amyotrophic Lateral Sclerosis; Antioxidants; Cystine; Glioma; Glutamic Acid; Humans; Microglia; Multiple Sclerosis; Parkinson Disease | 2023 |
1 trial(s) available for cystine and glutamic acid
| Article | Year |
|---|---|
Low plasma glutamine in combination with high glutamate levels indicate risk for loss of body cell mass in healthy individuals: the effect of N-acetyl-cysteine.
Topics: Acetylcysteine; Adult; Aerobiosis; Anaerobiosis; Body Weight; Cachexia; Cystine; Exercise; Female; Glutamic Acid; Glutamine; Glycine; Humans; Male; Middle Aged; Tyrosine | 1996 |
174 other study(ies) available for cystine and glutamic acid
| Article | Year |
|---|---|
T4+ cell numbers are correlated with plasma glutamate and cystine levels: association of hyperglutamataemia with immunodeficiency in diseases with different aetiologies.
Topics: CD4-Positive T-Lymphocytes; Cystine; Glutamates; Glutamic Acid; HIV Seropositivity; HIV-1; Humans; Immunologic Deficiency Syndromes; Lactates; Lactic Acid; Leukocyte Count; Lung Neoplasms; Pyruvates; Pyruvic Acid | 1992 |
A mechanism for glutamate toxicity in the C6 glioma cells involving inhibition of cystine uptake leading to glutathione depletion.
Topics: Animals; Biological Transport; Cell Line; Cystine; DNA, Neoplasm; Dose-Response Relationship, Drug; Glioma; Glutamates; Glutamic Acid; Glutathione; Kinetics; Neurotoxins; Rats; Sulfur Radioisotopes; Tritium | 1992 |
Mediated Na(+)-independent transport of L-glutamate and L-cystine in 1- and 2-cell mouse conceptuses.
Topics: Amino Acids; Animals; Biological Transport; Blastocyst; Cell Membrane Permeability; Cystine; Glutamates; Glutamic Acid; Hydrogen-Ion Concentration; In Vitro Techniques; Kinetics; Mice; Mice, Inbred ICR; Sodium; Sulfur Radioisotopes; Tritium | 1992 |
Production of phytochelatins in Polygonum cuspidatum on exposure to copper but not to zinc.
Topics: Cells, Cultured; Chromatography, Gel; Copper; Copper Sulfate; Cystine; Glutamates; Glutamic Acid; Glutathione; Glycine; Metalloproteins; Molecular Weight; Phytochelatins; Plant Development; Plant Proteins; Plants; Sulfates; Zinc; Zinc Sulfate | 1992 |
Differential effect of the amino acid cystine in cultured mammalian and bacterial cells exposed to oxidative stress.
Topics: Animals; Cell Division; Cell Survival; CHO Cells; Cricetinae; Cysteine; Cystine; Escherichia coli; Glutamates; Glutamic Acid; Glycine; Hydrogen Peroxide | 1992 |
Expression of the mouse macrophage cystine transporter in Xenopus laevis oocytes.
Topics: Animals; Carrier Proteins; Cells, Cultured; Centrifugation, Density Gradient; Cystine; Female; Gene Expression; Glutamates; Glutamic Acid; Hydrogen-Ion Concentration; Macrophages; Maleates; Mice; Mice, Inbred C57BL; Oocytes; Peritoneal Cavity; RNA, Messenger; Transfection; Xenopus laevis | 1991 |
Low membrane transport activity for cystine in resting and mitogenically stimulated human lymphocyte preparations and human T cell clones.
Topics: Alanine; Arginine; Biological Transport; Cell Division; Cell Membrane; Cells, Cultured; Clone Cells; Cysteine; Cystine; Glutamates; Glutamic Acid; HIV Seropositivity; Humans; Lymphocytes; Methionine; Mitogens; Phytohemagglutinins; T-Lymphocytes | 1991 |
Uptake of glutamate and cysteine in C-6 glioma cells and in cultured astrocytes.
Topics: Amino Acids; Animals; Astrocytes; Biological Transport; Cells, Cultured; Cystine; Excitatory Amino Acid Antagonists; Glioma; Glutamates; Glutamic Acid; Glutathione; Kinetics; Sodium; Tumor Cells, Cultured | 1990 |
L-glutamate binding site on N18-RE-105 neuroblastoma hybrid cells is not coupled to an ion channel.
Topics: Aminobutyrates; Animals; Binding, Competitive; Calcium; Chlorides; Cystine; Electric Conductivity; Fluorescent Antibody Technique; Glutamates; Glutamic Acid; Hybrid Cells; Intermediate Filament Proteins; Ion Channels; Mice; Neuroblastoma; Neurofilament Proteins; Neurons; Oxadiazoles; Potassium; Quisqualic Acid; Rats; Receptors, Glutamate; Receptors, Neurotransmitter; Sodium; Tumor Cells, Cultured | 1988 |
Cystine neurotoxicity is increased by taurine deficiency.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Cats; Cystine; Diet; Female; Glutamates; Glutamic Acid; L-Lactate Dehydrogenase; Nervous System; Photoreceptor Cells; Retina; Taurine; Tissue Distribution | 1989 |
Glutamate toxicity in a neuronal cell line involves inhibition of cystine transport leading to oxidative stress.
Topics: Animals; Biological Transport; Calcium; Cell Survival; Cystine; Depression, Chemical; Glutamates; Glutamic Acid; Glutathione; Hippocampus; Hybridomas; Mice; Neurons; Oxadiazoles; Oxidation-Reduction; Peroxides; Quisqualic Acid; Rats | 1989 |
Effect of insulin on the activity of amino acid transport systems in cultured human fibroblasts.
Topics: Amino Acids; Biological Transport, Active; Cells, Cultured; Cystine; Fibroblasts; Glutamates; Glutamic Acid; Humans; Insulin; Kinetics; Mathematics; Proline; Sodium | 1985 |
pH-profile of cystine and glutamate transport in normal and cystinotic human fibroblasts.
Topics: Biological Transport, Active; Cystine; Cystinosis; Fibroblasts; Glutamates; Glutamic Acid; Humans; Hydrogen-Ion Concentration | 1985 |
Splanchnic substrate balance in malnourished patients during parenteral nutrition.
Topics: Adipose Tissue; Alanine; Amino Acids, Branched-Chain; Cystine; Energy Metabolism; Fatty Acids, Nonesterified; Female; Glucose; Glutamates; Glutamic Acid; Glutamine; Glycine; Humans; Lipids; Liver; Male; Mesentery; Nitrogen; Parenteral Nutrition; Parenteral Nutrition, Total; Protein Biosynthesis; Protein-Energy Malnutrition; Serine; Splanchnic Circulation; Threonine; Tyrosine | 1985 |
Anti-inflammatory drug inhibition of transport of cystine and glutamate in cultured human fibroblasts.
Topics: Anti-Inflammatory Agents; Biological Transport; Cells, Cultured; Cystine; Depression, Chemical; Fibroblasts; Glutamates; Glutamic Acid; Humans; Sodium | 1985 |
The mechanism of glutamate-induced degeneration of cultured Huntington's disease and control fibroblasts.
Topics: Cells, Cultured; Cystine; Fibroblasts; Glutamates; Glutamic Acid; Glutathione; Homocysteine; Humans; Huntington Disease | 1985 |
Exchange of cystine and glutamate across plasma membrane of human fibroblasts.
Topics: Amino Acids; Binding, Competitive; Biological Transport, Active; Cell Membrane; Cysteine; Cystine; Ethylmaleimide; Fibroblasts; Glutamates; Glutamic Acid; Humans | 1986 |
Mouse lymphoma L1210 cells acquire a new cystine transport activity upon adaptation in vitro.
Topics: Amino Acids; Animals; Biological Transport; Cells, Cultured; Culture Media; Cystine; Ethylmaleimide; Glutamates; Glutamic Acid; Leukemia L1210; Mercaptoethanol; Mice; Sodium; Sulfhydryl Compounds | 1986 |
Cystine-glutamate transport interactions in rat renal cortical tubules, brushborder vesicles, and cultured renal tubule cells.
Topics: Animals; Biological Transport; Cell Membrane; Cells, Cultured; Culture Techniques; Cystine; Drug Interactions; Glutamates; Glutamic Acid; Kidney Cortex; Kidney Tubules; Lysine; Male; Microvilli; Rats; Rats, Inbred Strains | 1986 |
Induction of cystine transport activity in mouse peritoneal macrophages.
Topics: Amino Acids; Animals; Biological Transport; Cell Adhesion; Cells, Cultured; Cystine; Glutamates; Glutamic Acid; Hydrogen-Ion Concentration; Kinetics; Macrophages; Male; Mice; Mice, Inbred C57BL; Oxygen; Peritoneal Cavity; Sodium; Sulfhydryl Compounds; Thioglycolates | 1987 |
A novel function of glutamine in cell culture: utilization of glutamine for the uptake of cystine in human fibroblasts.
Topics: Biological Transport, Active; Cells, Cultured; Cysteine; Cystine; Fibroblasts; Glutamates; Glutamic Acid; Glutamine; Humans; Sodium | 1988 |
Protein deficiency potentiates oxygen toxicity.
Topics: Amino Acids; Animals; Cattle; Cells, Cultured; Cystine; Diet; Dietary Proteins; Endothelium, Vascular; Energy Intake; Glutamates; Glutamic Acid; Glutathione; Lung; Male; Models, Biological; Oxygen; Protein Deficiency; Rats; Rats, Inbred Strains; Sulfur | 1988 |
Tissue glutathione as a cyst(e)ine reservoir during fasting and refeeding of rats.
Topics: Animals; Cysteine; Cystine; Erythrocytes; Fasting; Food; Glutamates; Glutamic Acid; Glutathione; Glycine; Intestine, Small; Liver; Male; Muscles; Rats | 1981 |
Role of proton dissociation in the transport of cystine and glutamate in human diploid fibroblasts in culture.
Topics: Amino Acids; Biological Transport; Cell Line; Cystine; Glutamates; Glutamic Acid; Humans; Hydrogen-Ion Concentration; Kinetics | 1981 |
[Amino acid assimilation and secretion in dermatophytes. 2nd part: Amino acid catabolism and mycelial growth in Microsporum gypseum after cultivation in culture media containing different amino acids (author's transl)].
Topics: Amino Acids; Culture Media; Cystine; Glutamates; Glutamic Acid; Microsporum | 1981 |
[Degradation and assimilation of glucose and amino acids by Microsporum gypseum (author's transl)].
Topics: Amino Acids; Culture Media; Cystine; Glucose; Glutamates; Glutamic Acid; Microsporum; Nitrogen | 1982 |
Transport of cystine and cysteine and cell growth in cultured human diploid fibroblasts: effect of glutamate and homocysteate.
Topics: Amino Acids; Biological Transport; Cell Division; Cell Line; Culture Media; Cysteine; Cystine; Fibroblasts; Glutamates; Glutamic Acid; Glutathione; Homocysteine; Humans | 1982 |
Adaptive enhancement of cystine and glutamate uptake in human diploid fibroblasts in culture.
Topics: Adult; Amino Acids; Biological Transport; Cell Line; Cells, Cultured; Cystine; Diploidy; Embryo, Mammalian; Female; Fibroblasts; Glutamates; Glutamic Acid; Glutathione; Humans; Kinetics; Lung; Pregnancy; Skin | 1982 |
Induction of cystine and glutamate transport activity in human fibroblasts by diethyl maleate and other electrophilic agents.
Topics: Biological Transport; Cell Line; Cystine; Female; Fibroblasts; Glutamates; Glutamic Acid; Humans; Kinetics; Lung; Maleates; Pregnancy; Structure-Activity Relationship | 1984 |
Transport of cystine in isolated rat hepatocytes in primary culture.
Topics: Amino Acids; Animals; Biological Transport; Cells, Cultured; Cycloheximide; Cystine; Dactinomycin; Dexamethasone; Glutamates; Glutamic Acid; Insulin; Kinetics; Liver; Rats; Rats, Inbred Strains; Sodium | 1984 |
Serotonin protects C6 glioma cells from glutamate toxicity.
Topics: Animals; Antiporters; Cell Death; Cells, Cultured; Cerebellar Cortex; Cerebral Cortex; Cystine; Excitatory Amino Acid Antagonists; Glioma; Gliotoxin; Glutamates; Glutamic Acid; Glutathione; Lipid Peroxidation; Nerve Tissue Proteins; Neuroglia; Neurons; Neurotransmitter Agents; Quisqualic Acid; Rats; Serotonin; Tumor Cells, Cultured | 1994 |
Substance P regulation of glutamate and cystine transport in human astrocytoma cells.
Topics: Astrocytoma; Biological Transport, Active; Cystine; Glutamates; Glutamic Acid; Humans; Kinetics; Receptors, Neurokinin-1; Sodium; Substance P; Tumor Cells, Cultured | 1993 |
Isolation and partial characterization of rat sperm tail fibrous sheath proteins and comparison with rabbit and human spermatozoa using a polyclonal antiserum.
Topics: Animals; Aspartic Acid; Blotting, Western; Cystine; Electrophoresis, Polyacrylamide Gel; Fluorescent Antibody Technique; Glutamic Acid; Glycine; Humans; Immune Sera; Leucine; Male; Microscopy, Electron; Proteins; Rabbits; Rats; Rats, Sprague-Dawley; Serine; Sperm Tail | 1995 |
Induction of cystine transport activity in mouse peritoneal macrophages by bacterial lipopolysaccharide.
Topics: Amino Acids; Animals; Biological Transport; Cells, Cultured; Cystine; Dose-Response Relationship, Drug; Female; Glutamic Acid; Glutathione; Homocysteine; Interferon-gamma; Interleukin-1; Kinetics; Lipopolysaccharides; Macrophages, Peritoneal; Maleates; Mice; Mice, Inbred C57BL; Recombinant Proteins; Salmonella typhi; Serine; Tetradecanoylphorbol Acetate; Tumor Necrosis Factor-alpha; Zymosan | 1995 |
[Characteristics of the pool of blood free amino acids of rats during extended hypokinesis].
Topics: Amino Acids; Animals; Cystine; Dehydration; Glutamic Acid; Glutamine; Hypokinesia; Kidney; Liver; Male; Muscles; Myocardium; Neurosecretory Systems; Rats; Time Factors | 1995 |
Effect of reactive oxygen intermediates and antioxidants on proliferation and function of T lymphocytes.
Topics: Amino Acids; Antioxidants; Biological Transport; Cell Line; Cysteine; Cystine; DNA Replication; Glutamic Acid; Glutathione; Glutathione Disulfide; Humans; Hydrogen Peroxide; Kinetics; Lymphocyte Activation; Reactive Oxygen Species; T-Lymphocyte Subsets; T-Lymphocytes | 1994 |
Cystine uptake and glutathione level in fetal brain cells in primary culture and in suspension.
Topics: Animals; beta-Alanine; Biological Transport; Brain; Cells, Cultured; Cysteine; Cystine; Female; Fetus; Glutamates; Glutamic Acid; Glutathione; In Vitro Techniques; Kinetics; Neurons; Pregnancy; Rats; Rats, Wistar; Serine; Sodium; Time Factors | 1993 |
Plasma amino acid dysregulation after lentiviral infection.
Topics: Amino Acids; Animals; Arthritis-Encephalitis Virus, Caprine; Chlorocebus aethiops; Cysteine; Cystine; Glutamates; Glutamic Acid; Goat Diseases; Goats; Hepatitis B; HIV Infections; HIV-1; Humans; Lentivirus Infections; Macaca mulatta; Pan troglodytes; Proline; Simian Acquired Immunodeficiency Syndrome | 1993 |
Cystine/glutamate antiporter expression in retinal Müller glial cells: implications for DL-alpha-aminoadipate toxicity.
Topics: 2-Aminoadipic Acid; Animals; Antimetabolites; Autoradiography; Buthionine Sulfoximine; Carps; Carrier Proteins; Chlorides; Chromatography, High Pressure Liquid; Cystine; Electroretinography; Glutamates; Glutamic Acid; Glutathione; Isomerism; Methionine Sulfoximine; Neuroglia; Retina; Sodium; Sulfur Radioisotopes | 1993 |
Oxidant-antioxidant status in human immunodeficiency virus infection.
Topics: Amino Acids; Antioxidants; Biomarkers; Cell Separation; Cells, Cultured; Culture Techniques; Cysteine; Cystine; Female; Glutamates; Glutamic Acid; Glutathione; HIV Infections; HIV Seropositivity; Humans; Indicators and Reagents; Lymphocytes; Male; Monocytes; Oxidants; Reference Values; Sex Characteristics; Spectrophotometry | 1994 |
Vulnerability of oligodendroglia to glutamate: pharmacology, mechanisms, and prevention.
Topics: Animals; Astrocytes; Biological Transport; Cells, Cultured; Cystine; Excitatory Amino Acid Antagonists; Glutamates; Glutamic Acid; Glutathione; Immunohistochemistry; Oligodendroglia; Reactive Oxygen Species; Time Factors | 1993 |
Cellular oxidation of low density lipoprotein is caused by thiol production in media containing transition metal ions.
Topics: Animals; Cell Line; Cells, Cultured; Culture Media; Cysteine; Cystine; Endothelium, Vascular; Glutamates; Glutamic Acid; Lipoproteins, LDL; Macrophages; Maleates; Metals; Oxidation-Reduction; Sulfhydryl Compounds | 1993 |
Glutamate is transported across the rat blood-brain barrier by a sodium-independent system.
Topics: Amino Acid Transport System X-AG; Animals; Aspartic Acid; ATP-Binding Cassette Transporters; Biological Transport; Blood-Brain Barrier; Cystine; Glutamic Acid; Perfusion; Rats; Rats, Sprague-Dawley; Sodium; Time Factors | 1996 |
Reactive oxygen species involved in the glutamate toxicity of C6 glioma cells via xc antiporter system.
Topics: Adenosine Triphosphate; Animals; Antiporters; Brain Neoplasms; Cell Death; Cell Nucleus; Cystine; DNA Damage; Free Radical Scavengers; Glioma; Glutamate-Ammonia Ligase; Glutamic Acid; Glutathione; Glyceraldehyde-3-Phosphate Dehydrogenases; Lipid Peroxides; Rats; Reactive Oxygen Species; Tumor Cells, Cultured | 1996 |
Different preferences in the utilization of amino acids for glutathione synthesis in cultured neurons and astroglial cells derived from rat brain.
Topics: Amino Acids; Animals; Astrocytes; Brain; Cells, Cultured; Cysteine; Cystine; Glutamic Acid; Glutamine; Glutathione; Neurons; Rats; Rats, Wistar | 1996 |
Bicarbonate-sensitive cysteine induced elevation of extracellular aspartate and glutamate in rat hippocampus in vitro.
Topics: Animals; Aspartic Acid; Bicarbonates; Cysteine; Cystine; Extracellular Space; gamma-Aminobutyric Acid; Glutamic Acid; Hippocampus; In Vitro Techniques; Neurotransmitter Agents; Rats; Taurine | 1997 |
Transforming growth factor B1 decreases uptake of glutathione precursor amino acids in bovine pulmonary artery endothelial cells.
Topics: Animals; Biological Transport; Buthionine Sulfoximine; Cattle; Cell Count; Cells, Cultured; Cystine; Endothelium, Vascular; Enzyme Inhibitors; gamma-Glutamyltransferase; Glutamate-Cysteine Ligase; Glutamic Acid; Glutathione; Isoxazoles; Pulmonary Artery; Transforming Growth Factor beta | 1997 |
Role of glutathione metabolism in the glutamate-induced programmed cell death of neuronal-like PC12 cells.
Topics: Acetylcysteine; Animals; Antimetabolites, Antineoplastic; Apoptosis; Buthionine Sulfoximine; Culture Media, Serum-Free; Cycloheximide; Cystine; Glutamic Acid; Glutathione; L-Lactate Dehydrogenase; Neurons; Oxidative Stress; PC12 Cells; Protein Synthesis Inhibitors; Rats | 1997 |
Glutamate toxicity on a PC12 cell line involves glutathione (GSH) depletion and oxidative stress.
Topics: Animals; Antioxidants; Benzoquinones; Cell Death; Cystine; Dithiothreitol; Glutamic Acid; Glutathione; Glutathione Reductase; Kinetics; L-Lactate Dehydrogenase; Oxidative Stress; PC12 Cells; Rats; Selegiline; Ubiquinone; Vitamin E | 1997 |
Lipoic acid increases de novo synthesis of cellular glutathione by improving cystine utilization.
Topics: Animals; Cystine; Erythrocytes; Flow Cytometry; Glutamate-Cysteine Ligase; Glutamic Acid; Glutathione; Humans; Kinetics; Leukemia-Lymphoma, Adult T-Cell; Mice; Neuroblastoma; Neuroglia; Oxidation-Reduction; Rats; Thioctic Acid; Tumor Cells, Cultured | 1997 |
N18-RE-105 cells: differentiation and activation of p53 in response to glutamate and adriamycin is blocked by SV40 large T antigen tsA58.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Antigens, Polyomavirus Transforming; Antiporters; Apoptosis; Cell Differentiation; Cystine; Doxorubicin; Etoposide; Excitatory Amino Acid Agonists; Glutamic Acid; Homocysteine; Hybrid Cells; Mice; Neurites; Neuroblastoma; Neurons; Neurotoxins; Rats; Rats, Inbred F344; Retina; Temperature; Tumor Cells, Cultured; Tumor Suppressor Protein p53 | 1998 |
Plasma levels of neuroexcitatory amino acids in patients with migraine or tension headache.
Topics: Adult; Aged; Cysteine; Cystine; Excitatory Amino Acids; Female; Glutamic Acid; Humans; Male; Middle Aged; Migraine Disorders; Reactive Oxygen Species; Tension-Type Headache | 1998 |
Mutagenesis of Glu403 to Cys in rabbit neutral endopeptidase-24.11 (neprilysin) creates a disulphide-linked homodimer: analogy with endothelin-converting enzyme.
Topics: Amino Acid Sequence; Amino Acid Substitution; Animals; Aspartic Acid Endopeptidases; COS Cells; Cystine; Dimerization; Disulfides; Endothelin-Converting Enzymes; Enkephalin, Leucine-2-Alanine; Glutamic Acid; Glycopeptides; Humans; Immunoblotting; Kinetics; Metalloendopeptidases; Molecular Sequence Data; Mutagenesis, Site-Directed; Neprilysin; Oligopeptides; Protease Inhibitors; Protein Conformation; Rabbits; Rats; Thiorphan | 1997 |
Determinants of glutamine dependence and utilization by normal and tumor-derived breast cell lines.
Topics: Biological Transport; Breast Neoplasms; Carbon Dioxide; Cell Division; Culture Media; Cystine; Glutamic Acid; Glutamine; Glutathione; Humans; Kinetics; Sodium; Tumor Cells, Cultured | 1998 |
Phosphatidylcholine-specific phospholipase C regulates glutamate-induced nerve cell death.
Topics: Animals; Antimetabolites; Apoptosis; Bridged-Ring Compounds; Buthionine Sulfoximine; Cell Line; Cystine; Glutamic Acid; Hippocampus; Mice; Neurons; Norbornanes; Phosphodiesterase Inhibitors; Thiocarbamates; Thiones; Type C Phospholipases | 1998 |
Cellular mechanisms of resistance to chronic oxidative stress.
Topics: Animals; Antioxidants; bcl-2-Associated X Protein; Biological Transport; Catalase; Cell Line; Cell Survival; Cystathionine; Cystine; Drug Resistance; Glutamate-Cysteine Ligase; Glutamic Acid; Glutathione; Heat-Shock Proteins; Homocysteine; Mice; Myeloid Cell Leukemia Sequence 1 Protein; Neoplasm Proteins; Oxidative Stress; Oxidoreductases; Oxidoreductases Acting on CH-CH Group Donors; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Time Factors; Up-Regulation | 1998 |
The glutathione content of retinal Müller (glial) cells: the effects of aging and of application of free-radical scavengers.
Topics: Aging; Animals; Cells, Cultured; Culture Media; Cystine; Flavonoids; Free Radical Scavengers; Ginkgo biloba; Glutamic Acid; Glutathione; Guinea Pigs; Male; Neuroglia; Plant Extracts; Retina | 1998 |
Hepatic export of glutathione and uptake of constituent amino acids, glutamate and cysteine, in broilers in vivo.
Topics: Animals; Biological Transport; Carotid Arteries; Chickens; Cysteine; Cystine; Dipeptides; Enzyme Inhibitors; gamma-Glutamyltransferase; Glutamic Acid; Glutathione; Hepatic Veins; Isoxazoles; Liver; Male; Portal Vein | 1998 |
Modulation of extracellular glutamate concentration in rat brain slices by cystine-glutamate exchange.
Topics: 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid; Animals; Brain Chemistry; Cerebellum; Cystine; Excitatory Amino Acid Antagonists; Extracellular Space; Furosemide; Glutamic Acid; In Vitro Techniques; Kinetics; Membrane Potentials; Patch-Clamp Techniques; Purkinje Cells; Pyramidal Cells; Rats; Receptors, Glutamate | 1999 |
Stimulation of cystine uptake by nitric oxide: regulation of endothelial cell glutathione levels.
Topics: Animals; Aorta; Biological Transport; Cattle; Cells, Cultured; Cycloheximide; Cystine; Cytosol; Dactinomycin; Endothelium, Vascular; Glutamic Acid; Glutathione; Kinetics; Nitric Oxide; Penicillamine; S-Nitroso-N-Acetylpenicillamine; Time Factors | 1999 |
Cystine protects cochlear outer hair cells against glutamate toxicity.
Topics: Analysis of Variance; Animals; Antiporters; Cell Death; Cystine; Drug Interactions; Glutamic Acid; Guinea Pigs; Hair Cells, Auditory, Outer; Time Factors | 1999 |
Compromised glutamate transport in human glioma cells: reduction-mislocalization of sodium-dependent glutamate transporters and enhanced activity of cystine-glutamate exchange.
Topics: Amino Acid Substitution; Amino Acid Transport System X-AG; Animals; Astrocytes; ATP-Binding Cassette Transporters; Benzoates; Brain Neoplasms; Cells, Cultured; Cystine; Excitatory Amino Acid Antagonists; Glioma; Glucose Transporter Type 1; Glutamic Acid; Glycine; Humans; Monosaccharide Transport Proteins; Rats; Rats, Sprague-Dawley; Sodium; Tissue Distribution | 1999 |
Kinetic and pharmacological analysis of L-[35S]cystine transport into rat brain synaptosomes.
Topics: Amino Acid Transport System X-AG; Animals; Aspartic Acid; ATP-Binding Cassette Transporters; Biological Transport; Brain; Cystine; Glutamic Acid; In Vitro Techniques; Kinetics; Rats; Rats, Wistar; Sodium; Sulfur Radioisotopes; Synaptosomes; Tritium | 2000 |
Flupirtine and retigabine prevent L-glutamate toxicity in rat pheochromocytoma PC 12 cells.
Topics: Aminopyridines; Analgesics; Animals; Antidepressive Agents; Carbamates; Cell Death; Clorgyline; Culture Media; Cystine; Dopamine Agents; Excitatory Amino Acid Antagonists; Glutamic Acid; Glutathione; Levodopa; Monoamine Oxidase; Monoamine Oxidase Inhibitors; PC12 Cells; Phenylenediamines; Rats; Reactive Oxygen Species; Receptors, N-Methyl-D-Aspartate | 2000 |
Adaptive responses to peroxynitrite: increased glutathione levels and cystine uptake in vascular cells.
Topics: Adaptation, Physiological; Animals; Cattle; Cells, Cultured; Cystine; Dose-Response Relationship, Drug; Endothelium, Vascular; Free Radical Scavengers; Glutamic Acid; Glutathione; Metalloporphyrins; Molsidomine; Muscle, Smooth, Vascular; Nitrates; Nitric Oxide Donors; Nucleic Acid Synthesis Inhibitors; Penicillamine; Protein Synthesis Inhibitors; S-Nitroso-N-Acetylpenicillamine; Sodium; Superoxide Dismutase | 2000 |
Structure, function, and regulation of human cystine/glutamate transporter in retinal pigment epithelial cells.
Topics: Amino Acid Sequence; Amino Acid Transport System y+; Carrier Proteins; Cells, Cultured; Cloning, Molecular; Cystine; DNA Primers; Eye Proteins; Gene Expression; Gene Library; Glutamic Acid; Glyceraldehyde-3-Phosphate Dehydrogenases; Humans; Molecular Sequence Data; Nitric Oxide; Penicillamine; Pigment Epithelium of Eye; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sequence Homology, Amino Acid; Structure-Activity Relationship; Substrate Specificity | 2001 |
Molecular cloning and expression of human xCT, the light chain of amino acid transport system xc-.
Topics: Amino Acid Sequence; Amino Acid Transport System y+; Animals; Base Sequence; Carrier Proteins; Cell Line, Transformed; Chromosome Mapping; Chromosomes, Human, Pair 4; Cloning, Molecular; Cystine; DNA Primers; DNA, Complementary; Female; Gene Expression; Glutamic Acid; Humans; Mice; Molecular Sequence Data; Oocytes; Recombinant Proteins; Sequence Homology, Amino Acid; Xenopus | 2000 |
Secretion of thioredoxin enhances cellular resistance to cis-diamminedichloroplatinum (II).
Topics: Biological Transport, Active; Cell Survival; Cisplatin; Cystine; Drug Resistance; Glutamic Acid; HeLa Cells; Humans; Recombinant Proteins; Thioredoxins | 2000 |
Methylmercury inhibits the in vitro uptake of the glutathione precursor, cystine, in astrocytes, but not in neurons.
Topics: Animals; Animals, Newborn; Astrocytes; Cerebral Cortex; Cystine; Embryo, Mammalian; gamma-Glutamyltransferase; Glutamic Acid; Hippocampus; Methylmercury Compounds; Neurons; Rats; Rats, Sprague-Dawley | 2001 |
xCt cystine transporter expression in HEK293 cells: pharmacology and localization.
Topics: Amino Acid Transport System y+; Animals; Antigens, CD; Biological Transport; Carrier Proteins; Cell Line; Cell Membrane; Cystine; Fusion Regulatory Protein-1; Genetic Vectors; Glutamic Acid; Green Fluorescent Proteins; Humans; Intracellular Fluid; Kidney; Luminescent Proteins; Mice; Oxidative Stress; Protein Subunits; Recombinant Fusion Proteins; Transfection | 2001 |
Activation of carrier-mediated transport of L-cystine at the blood-brain and blood-retinal barriers in vivo.
Topics: 2-Aminoadipic Acid; Animals; Aspartic Acid; Biological Transport; Blood-Brain Barrier; Blood-Retinal Barrier; Cystine; Glutamic Acid; Male; Maleates; Rats; Rats, Wistar | 2001 |
Determination of amino acids by ion-exchange chromatography on filter paper spotted blood samples stored at different temperatures and for different periods: comparison with capillary and venous blood.
Topics: Adolescent; Adult; Age Factors; Amino Acids; Blood Specimen Collection; Capillaries; Chromatography, Ion Exchange; Cold Temperature; Cystine; Glutamic Acid; Histidine; Humans; Methionine; Ornithine; Paper; Reproducibility of Results; Serine; Temperature; Veins | 2001 |
L-Quisqualic acid transport into hippocampal neurons by a cystine-sensitive carrier is required for the induction of quisqualate sensitization.
Topics: Animals; Biological Transport, Active; Carrier Proteins; Cell Membrane; Cystine; Drug Interactions; Enzyme Inhibitors; gamma-Aminobutyric Acid; Glutamic Acid; Hippocampus; Immunohistochemistry; Interneurons; Male; Membrane Potentials; Neurotoxins; Organ Culture Techniques; Pharmacokinetics; Pyramidal Cells; Quisqualic Acid; Rats; Rats, Sprague-Dawley; Sulfur Radioisotopes | 2001 |
Oxidative glutamate toxicity can be a component of the excitotoxicity cascade.
Topics: 2-Amino-5-phosphonovalerate; Amino Acid Transport System y+; Animals; Carrier Proteins; Cell Count; Cell Death; Cell Survival; Cells, Cultured; Cerebral Cortex; Culture Media, Conditioned; Cystine; Excitatory Amino Acid Antagonists; Glutamic Acid; Glutathione; Mice; Mice, Inbred BALB C; Neurons; Oxidative Stress; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Time Factors | 2001 |
Role of glutamate transporters in the regulation of glutathione levels in human macrophages.
Topics: Amino Acid Transport System y+; Carrier Proteins; Cells, Cultured; Cystine; Excitatory Amino Acid Transporter 1; Excitatory Amino Acid Transporter 2; Glutamic Acid; Glutathione; Humans; Macrophages; Models, Biological | 2001 |
Glutamate induces oxidative stress not mediated by glutamate receptors or cystine transporters: protective effect of melatonin and other antioxidants.
Topics: Acetylcysteine; Animals; Antioxidants; Ascorbic Acid; Brain; Carrier Proteins; Cystine; Glutamic Acid; Glutathione; Male; Melatonin; Oxidative Stress; Rats; Rats, Wistar; Receptors, Glutamate | 2001 |
Gamma-glutamyl transpeptidase and glutathione biosynthesis in non-tumorigenic and tumorigenic rat liver oval cell lines.
Topics: Aminopeptidases; Animals; Cell Division; Cell Line; Cystine; Enzyme Inhibitors; gamma-Glutamyltransferase; Glutamic Acid; Glutamine; Glutathione; Kinetics; Liver; Rats; Tumor Cells, Cultured | 2001 |
Amino acid concentrations in the blood of the jugular vein and peripheral artery after traumatic brain injury: decreased release of glutamate into the jugular vein in the early phase.
Topics: Adolescent; Adult; Aged; Amino Acids; Arteries; Aspartic Acid; Brain Injuries; Cystine; Female; gamma-Aminobutyric Acid; Glutamic Acid; Glutamine; Humans; Jugular Veins; Male; Middle Aged | 2002 |
Enhancement of L-cystine transport activity and its relation to xCT gene induction at the blood-brain barrier by diethyl maleate treatment.
Topics: Algorithms; Amino Acid Transport System y+; Animals; Biological Transport; Blood-Brain Barrier; Carrier Proteins; Cells, Cultured; Cystine; Gene Expression Regulation; Glutamic Acid; Glutathione; Kinetics; Male; Maleates; Mice; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sodium; Stimulation, Chemical; Transcriptional Activation | 2002 |
Specificity of resistance to oxidative stress.
Topics: Amyloid beta-Peptides; Animals; Apoptosis; Cell Line; Cystine; Drug Resistance; Glutamic Acid; Hydrogen Peroxide; Mice; Neurons; Neurotoxins; Oxidants; Oxidative Stress | 2002 |
gamma-Glutamyl transpeptidase and glutathione biosynthesis in non-tumorigenic and tumorigenic rat liver oval cell lines.
Topics: Aminopeptidases; Animals; Cell Division; Cell Line; Cystine; Enzyme Inhibitors; gamma-Glutamyltransferase; Glutamic Acid; Glutamine; Glutathione; Kinetics; Liver; Rats; Tumor Cells, Cultured | 2002 |
Cystine/glutamate exchange serves as the source for extracellular glutamate: modifications by repeated cocaine administration.
Topics: Animals; Biological Transport; Calcium Channel Blockers; Cocaine; Cystine; Diltiazem; Dopamine Uptake Inhibitors; Glutamic Acid; Microdialysis; Nucleus Accumbens; omega-Conotoxins; Rats; Tetrodotoxin | 2002 |
Modulation of group II metabotropic glutamate receptor signaling by chronic cocaine.
Topics: Animals; Blotting, Western; Brain; Cocaine; Cystine; Glutamic Acid; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Male; Microdialysis; Phosphorylation; Potassium; Precipitin Tests; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; Signal Transduction; Sulfur Radioisotopes | 2002 |
Expression of the activity of cystine/glutamate exchange transporter, system x(c)(-), by xCT and rBAT.
Topics: 3T3 Cells; Amino Acid Transport System y+; Amino Acid Transport Systems, Basic; Amino Acids; Animals; Biological Transport; Carrier Proteins; Cystine; Epithelial Cells; Fusion Regulatory Protein 1, Heavy Chain; Glutamic Acid; Membrane Glycoproteins; Mice; Oocytes; Protein Subunits; RNA Interference; RNA, Messenger; Xenopus | 2003 |
Neuroadaptations in cystine-glutamate exchange underlie cocaine relapse.
Topics: Acetylcysteine; Adaptation, Physiological; Analysis of Variance; Animals; Cocaine; Cocaine-Related Disorders; Conditioning, Operant; Corpus Striatum; Cystine; Dose-Response Relationship, Drug; Expectorants; Extinction, Psychological; Extracellular Space; Glutamic Acid; Male; Nucleus Accumbens; Prefrontal Cortex; Rats; Rats, Sprague-Dawley; Recurrence; Reinforcement, Psychology; Self Administration; Substance Withdrawal Syndrome; Time Factors | 2003 |
Expression and regulation of L-cystine transporter, system xc-, in the newly developed rat retinal Müller cell line (TR-MUL).
Topics: Animals; Animals, Genetically Modified; Antigens, Viral, Tumor; Aspartic Acid; Biomarkers; Carrier Proteins; Cell Line, Transformed; Cystine; Fusion Regulatory Protein 1, Heavy Chain; Glutamic Acid; Glutathione; Male; Maleates; Models, Biological; Neuroglia; Oxidative Stress; Rats; Rats, Wistar; Retina; Retinal Diseases; Up-Regulation | 2003 |
Aspartate 345 of the dopamine transporter is critical for conformational changes in substrate translocation and cocaine binding.
Topics: Alanine; Aspartic Acid; Biological Transport; Biotinylation; Blotting, Western; Cell Line; Cell Membrane; Cocaine; Cystine; Dopamine; Dopamine Plasma Membrane Transport Proteins; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Glutamic Acid; Humans; Kinetics; Ligands; Membrane Glycoproteins; Membrane Transport Proteins; Mesylates; Mutation; Nerve Tissue Proteins; Phenotype; Piperazines; Protein Binding; Protein Conformation; Protein Transport; Sodium; Time Factors; Zinc | 2004 |
Differentiation of substrate and non-substrate inhibitors of transport system xc(-): an obligate exchanger of L-glutamate and L-cystine.
Topics: Amino Acid Transport System y+; Animals; Carrier Proteins; Cell Line, Tumor; Cystine; Glutamic Acid; Humans; Rats; Substrate Specificity | 2004 |
Amino acids and asthma: a case-control study.
Topics: Adolescent; Adult; Aged; Amino Acids; Arginine; Asthma; Case-Control Studies; Cystine; Fasting; Female; Glutamic Acid; Glutamine; Glutathione; Glycine; Humans; Male; Methionine; Middle Aged; Odds Ratio; Phenylalanine; Tryptophan | 2004 |
Glial glutamate transporters limit spillover activation of presynaptic NMDA receptors and influence synaptic inhibition of Purkinje neurons.
Topics: Action Potentials; Amino Acid Transport System X-AG; Animals; Antiporters; Calcium; Cerebellum; Cystine; Evoked Potentials; gamma-Aminobutyric Acid; Glutamic Acid; In Vitro Techniques; Mice; Nerve Fibers; Neural Inhibition; Neuroglia; Patch-Clamp Techniques; Purkinje Cells; Receptors, N-Methyl-D-Aspartate; Receptors, Presynaptic; Ryanodine; Synaptic Transmission | 2004 |
Excitatory amino acid induced oligodendrocyte cell death in vitro: receptor-dependent and -independent mechanisms.
Topics: 2',3'-Cyclic-Nucleotide Phosphodiesterases; Animals; Animals, Newborn; Annexin A5; Blotting, Western; Cell Death; Cell Survival; Cells, Cultured; Cerebral Cortex; Chromatin Assembly and Disassembly; Cystine; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Excitatory Amino Acids; Fluoresceins; G(M1) Ganglioside; Glial Fibrillary Acidic Protein; Glucose; Glutamic Acid; Hypoxia; Immunohistochemistry; Indoles; JNK Mitogen-Activated Protein Kinases; Kainic Acid; MAP Kinase Kinase 4; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Myelin Basic Protein; Myelin Proteins; Myelin-Associated Glycoprotein; Nogo Proteins; Oligodendroglia; Oligopeptides; Peroxides; Phosphorylation; Quinoxalines; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Receptors, Cell Surface; Signal Transduction; Time Factors | 2004 |
The Lathyrus excitotoxin beta-N-oxalyl-L-alpha,beta-diaminopropionic acid is a substrate of the L-cystine/L-glutamate exchanger system xc-.
Topics: Amino Acid Transport System y+; Amino Acids, Diamino; Animals; Binding, Competitive; Cell Line, Tumor; Cyanobacteria Toxins; Cystine; Fluorometry; Glutamic Acid; Glycine; Humans; Kinetics; Neurotoxins; Quisqualic Acid; Rats; Receptors, Glutamate | 2004 |
Transcriptional control of cystine/glutamate transporter gene by amino acid deprivation.
Topics: Activating Transcription Factor 4; Amino Acid Transport System y+; Amino Acids; Animals; Base Sequence; Biological Transport; Cystine; Fusion Regulatory Protein 1, Heavy Chain; Gene Expression Regulation; Glutamic Acid; Mice; Molecular Sequence Data; NIH 3T3 Cells; Promoter Regions, Genetic; Recombinant Fusion Proteins; Response Elements; Sequence Alignment; Trans-Activators; Transcription, Genetic | 2004 |
Transport of L-[14C]cystine and L-[14C]cysteine by subtypes of high affinity glutamate transporters over-expressed in HEK cells.
Topics: Amino Acid Transport System X-AG; Biological Transport, Active; Carbon Radioisotopes; Carrier Proteins; Cell Line; Cell Membrane; Cysteine; Cystine; Dipeptides; Excitatory Amino Acid Transporter 1; Excitatory Amino Acid Transporter 2; Excitatory Amino Acid Transporter 3; Extracellular Fluid; Glutamate Plasma Membrane Transport Proteins; Glutamic Acid; Glutathione; Homocysteine; Humans; Kinetics; Oxidation-Reduction; Symporters | 2005 |
Cystine/glutamate exchange regulates metabotropic glutamate receptor presynaptic inhibition of excitatory transmission and vulnerability to cocaine seeking.
Topics: Amino Acids; Animals; Biological Transport; Cocaine; Cocaine-Related Disorders; Consummatory Behavior; Cystine; Excitatory Amino Acid Antagonists; Extinction, Psychological; Glutamic Acid; Male; Neural Conduction; Nucleus Accumbens; Prefrontal Cortex; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; Receptors, Presynaptic; Self Administration; Xanthenes | 2005 |
Cystine and glutamate transport in renal epithelial cells transfected with human system x(-) (c).
Topics: Amino Acid Transport System y+; Animals; Cell Line; Cystine; Dogs; Epithelial Cells; Glutamic Acid; Humans; Kidney; Oocytes; Reverse Transcriptase Polymerase Chain Reaction; Transfection; Xenopus laevis | 2005 |
Protective effect of L-trans-pyrrolidine-2,4-dicarboxilic acid preload against cell death induced by oxygen/glucose deprivation in differentiated PC12 cells.
Topics: Adenosine Triphosphate; Animals; Blotting, Western; Cell Death; Cell Differentiation; Cell Survival; Cystine; Dicarboxylic Acids; Drug Interactions; Eukaryotic Initiation Factor-2; Extracellular Space; Glucose; Glutamic Acid; Glutathione; Glutathione Reductase; HSP70 Heat-Shock Proteins; Hypoxia; Models, Biological; Neuroprotective Agents; PC12 Cells; Pyrrolidines; Rats; Time Factors | 2005 |
Distinct nuclear factor-kappaB/Rel proteins have opposing modulatory effects in glutamate-induced cell death in HT22 cells.
Topics: Amino Acid Transport System y+; Animals; Aspirin; Cell Death; Cell Line, Transformed; Cell Survival; Cyclooxygenase Inhibitors; Cystine; Glutamic Acid; I-kappa B Proteins; Mice; Nerve Degeneration; Neurons; NF-kappa B; NF-kappa B p50 Subunit; Oligonucleotides, Antisense; Oxidative Stress; Proto-Oncogene Proteins c-rel; Transcription Factor RelA | 2005 |
Glutamate inhibits chondral mineralization through apoptotic cell death mediated by retrograde operation of the cystine/glutamate antiporter.
Topics: Animals; Antiporters; Apoptosis; Calcification, Physiologic; Cartilage; Cell Differentiation; Cell Proliferation; Cells, Cultured; Chondrocytes; Cystine; Female; Glutamate Plasma Membrane Transport Proteins; Glutamic Acid; Metatarsal Bones; Mice; Rats; Rats, Wistar; RNA, Messenger | 2006 |
Cystine/glutamate exchange modulates glutathione supply for neuroprotection from oxidative stress and cell proliferation.
Topics: Animals; Animals, Newborn; Cell Line; Cell Proliferation; Cells, Cultured; Cystine; Glutamic Acid; Glutathione; Humans; Mice; Mice, Inbred C3H; Mice, Transgenic; Neurons; Neuroprotective Agents; Oxidative Stress; Rats; Rats, Wistar | 2006 |
Glutamate suppresses osteoclastogenesis through the cystine/glutamate antiporter.
Topics: Amino Acid Transport System y+; Animals; Antiporters; Bone Density; Cell Differentiation; Cell Line; Cells, Cultured; Cystine; Dose-Response Relationship, Drug; Excitatory Amino Acid Transporter 3; Gene Expression; Glutamic Acid; Luciferases; Macrophage Colony-Stimulating Factor; Male; Mice; Osteoclasts; Ovariectomy; Promoter Regions, Genetic; Protein Subunits; RANK Ligand; Receptors, Glutamate; Reverse Transcriptase Polymerase Chain Reaction; Time Factors; Transfection | 2007 |
Expression and developmental regulation of the cystine/glutamate exchanger (xc-) in the rat.
Topics: Amino Acid Transport Systems; Animals; Astrocytes; Blotting, Western; Cerebral Cortex; Chlorocebus aethiops; COS Cells; Cystine; Electrophoresis, Polyacrylamide Gel; Fibroblasts; Gene Expression Regulation, Developmental; Glutamic Acid; Humans; Immunoblotting; Immunohistochemistry; Male; Mice; Neurons; Rats; Rats, Sprague-Dawley; Subcellular Fractions | 2007 |
System xc- and glutamate transporter inhibition mediates microglial toxicity to oligodendrocytes.
Topics: Amino Acid Transport System X-AG; Animals; Cell Death; Cells, Cultured; Coculture Techniques; Cystine; Excitatory Postsynaptic Potentials; Glutamic Acid; Homeostasis; Inflammation Mediators; Lipopolysaccharides; Microglia; Oligodendroglia; Optic Nerve; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species | 2007 |
Suppression by glutamate of proliferative activity through glutathione depletion mediated by the cystine/glutamate antiporter in mesenchymal C3H10T1/2 stem cells.
Topics: Animals; Antiporters; Cell Culture Techniques; Cell Proliferation; Cells, Cultured; Cystine; DNA Primers; Formazans; Genes, Reporter; Glutamic Acid; Glutathione; L-Lactate Dehydrogenase; Luciferases; Mesoderm; Mice; Propidium; Reverse Transcriptase Polymerase Chain Reaction; Stem Cells; Taq Polymerase; Tetrazolium Salts | 2007 |
Amino acid composition of two masticatory nuts (Cola acuminata and Garcinia kola) and a snack nut (Anacardium occidentale).
Topics: Amino Acids; Amino Acids, Acidic; Amino Acids, Essential; Anacardium; Arginine; Aspartic Acid; Cola; Cystine; Garcinia kola; Glutamic Acid; Isoelectric Point; Nuts; Threonine; Valine | 2007 |
The cystine/cysteine cycle: a redox cycle regulating susceptibility versus resistance to cell death.
Topics: Amino Acid Transport System y+; Animals; Antimetabolites, Antineoplastic; Apoptosis; Blotting, Northern; Buthionine Sulfoximine; Caspases; Cell Survival; Cysteine; Cystine; Fluorescent Antibody Technique; Glutamic Acid; Glutathione; Humans; Hydrogen Peroxide; Immunoblotting; Lipid Peroxidation; Membrane Potential, Mitochondrial; Mice; Oxidants; Oxidation-Reduction; Oxidative Stress; Reactive Oxygen Species | 2008 |
Mapping of glutathione and its precursor amino acids reveals a role for GLYT2 in glycine uptake in the lens core.
Topics: Amino Acid Transport System ASC; Animals; Blotting, Western; Chromatography, High Pressure Liquid; Cystine; Excitatory Amino Acid Transporter 4; Excitatory Amino Acid Transporter 5; Fluorescent Antibody Technique, Indirect; Glutamic Acid; Glutathione; Glycine; Glycine Plasma Membrane Transport Proteins; Lens Nucleus, Crystalline; Microscopy, Confocal; Minor Histocompatibility Antigens; Protein Precursors; Rats; Rats, Wistar | 2007 |
Enhancement of antigen-specific immunoglobulin G production in mice by co-administration of L-cystine and L-theanine.
Topics: Adjuvants, Immunologic; Administration, Oral; Animals; Antibody Specificity; Cystine; Dextrans; Dose-Response Relationship, Drug; Female; Glutamates; Glutamic Acid; Glutathione; Hemocyanins; Immunoglobulin E; Immunoglobulin G; Interferon-gamma; Interleukin-10; Liver; Mice; Mice, Inbred BALB C | 2007 |
Blunted cystine-glutamate antiporter function in the nucleus accumbens promotes cocaine-induced drug seeking.
Topics: Animals; Antiporters; Behavior, Animal; Cocaine; Cocaine-Related Disorders; Cystine; Dopamine Uptake Inhibitors; Extinction, Psychological; Glutamic Acid; Male; Microdialysis; Nucleus Accumbens; Rats; Rats, Sprague-Dawley; Self Administration; Synapses | 2008 |
Repeated exposure to cocaine alters the modulation of mesocorticolimbic glutamate transmission by medial prefrontal cortex Group II metabotropic glutamate receptors.
Topics: Amino Acids; Animals; Cocaine; Cocaine-Related Disorders; Cystine; Disease Models, Animal; Dopamine Uptake Inhibitors; Drug Administration Schedule; Excitatory Amino Acid Antagonists; Glutamic Acid; Limbic System; Male; Neural Pathways; Prefrontal Cortex; Presynaptic Terminals; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; Synaptic Transmission; Synaptic Vesicles; Ventral Tegmental Area; Xanthenes | 2008 |
A novel approach to enhancing cellular glutathione levels.
Topics: Animals; Antioxidants; Biological Transport; Catechin; Chromatography, High Pressure Liquid; Cysteamine; Cysteine; Cystine; Glutamic Acid; Glutathione; Neurons; Oxidative Stress; Rats | 2008 |
Computational model of extracellular glutamate in the nucleus accumbens incorporates neuroadaptations by chronic cocaine.
Topics: Action Potentials; Amino Acid Transport System X-AG; Anesthetics, Local; Animals; Cocaine; Computer Simulation; Cystine; Extracellular Fluid; Glutamic Acid; Models, Biological; Neuroglia; Neurons; Nucleus Accumbens; Rats; Receptors, Glutamate; Synapses; Synaptic Transmission | 2009 |
beta-N-methylamino-l-alanine induces oxidative stress and glutamate release through action on system Xc(-).
Topics: Amino Acid Transport System y+; Amino Acids, Diamino; Amyotrophic Lateral Sclerosis; Animals; Cells, Cultured; Central Nervous System; Coculture Techniques; Cyanobacteria Toxins; Cystine; Excitatory Amino Acid Agonists; Extracellular Space; Glutamic Acid; Glutathione; Mice; Neurodegenerative Diseases; Neurons; Neurotoxins; Oxidative Stress; Receptor, Metabotropic Glutamate 5; Receptors, Metabotropic Glutamate | 2009 |
The x(c)(-) cystine/glutamate antiporter (xCT) as a potential target for therapy of cancer: yet another cytotoxic anticancer approach?
Topics: Amino Acid Transport System y+; Antineoplastic Agents; Antiporters; Brain Neoplasms; Cystine; Glutamic Acid; Humans; Protein Subunits | 2009 |
Ceftriaxone restores glutamate homeostasis and prevents relapse to cocaine seeking.
Topics: Analysis of Variance; Animals; Antioxidants; Ceftriaxone; Cocaine; Cocaine-Related Disorders; Conditioning, Operant; Cystine; Disease Models, Animal; Dopamine Uptake Inhibitors; Excitatory Amino Acid Transporter 2; Glutamic Acid; Male; Motor Activity; Nucleus Accumbens; Rats; Rats, Sprague-Dawley; Self Administration; Time Factors; Tritium | 2010 |
[Fluorescence analysis of trace glucose using glucose oxidase and horseradish peroxidase].
Topics: Cystine; Fluorescence; Glucose; Glucose Oxidase; Glutamic Acid; Horseradish Peroxidase; Hydrogen Peroxide; Lysine; Oxidation-Reduction; Rhodamines; Spectrometry, Fluorescence; Tyrosine | 2009 |
The DC gate in Channelrhodopsin-2: crucial hydrogen bonding interaction between C128 and D156.
Topics: Algal Proteins; Amino Acid Substitution; Aspartic Acid; Chlamydomonas reinhardtii; Cystine; Glutamic Acid; Hydrogen Bonding; Ion Channels; Mutagenesis, Site-Directed; Protein Structure, Tertiary; Recombinant Proteins; Spectroscopy, Fourier Transform Infrared | 2010 |
Lactacidosis modulates glutathione metabolism and oxidative glutamate toxicity.
Topics: Acidosis; Animals; Antioxidants; Astrocytes; Cell Line, Transformed; Cell Survival; Cells, Cultured; Cerebral Cortex; Cystine; Dose-Response Relationship, Drug; Embryo, Mammalian; Flavonoids; Flavonols; Glutamic Acid; Glutathione; Hydrogen-Ion Concentration; Lactic Acid; Mice; Neurons; Oxidative Stress; Quercetin; Sulfur Isotopes; Time Factors; Tritium | 2010 |
Transcriptional profiles for glutamate transporters reveal differences between organophosphates but similarities with unrelated neurotoxicants.
Topics: Amino Acid Transport System X-AG; Analysis of Variance; Animals; Cell Differentiation; Chlorpyrifos; Cholinesterase Inhibitors; Cystine; Diazinon; Gene Expression Profiling; Gene Expression Regulation; Glutamic Acid; Maximum Tolerated Dose; Nerve Growth Factor; Neurotoxins; Oligonucleotide Array Sequence Analysis; Organophosphates; PC12 Cells; Rats; Statistics as Topic; Time Factors | 2010 |
Glutamate preferentially suppresses osteoblastogenesis than adipogenesis through the cystine/glutamate antiporter in mesenchymal stem cells.
Topics: Adipocytes; Adipogenesis; Amino Acid Transport System y+; Animals; Bone Marrow Cells; Cell Differentiation; Cell Line; Core Binding Factor Alpha 1 Subunit; Cystine; Glutamic Acid; Glutathione; Mesenchymal Stem Cells; Mice; Osteoblasts; Osteogenesis; Oxidation-Reduction; RNA, Small Interfering; Stromal Cells | 2011 |
The cystine/glutamate antiporter regulates dendritic cell differentiation and antigen presentation.
Topics: Amino Acid Transport System y+; Animals; Antigen Presentation; Biological Transport; Cell Differentiation; Cells, Cultured; Cross-Priming; Cystine; Dendritic Cells; Glutamic Acid; Glutathione; Homeostasis; Humans; Intracellular Fluid; Lipopolysaccharides; Mice; Mice, Inbred C57BL; Mice, Transgenic; Ovalbumin | 2010 |
Dissection of mitogenic and neurodegenerative actions of cystine and glutamate in malignant gliomas.
Topics: Animals; Brain Neoplasms; Cell Growth Processes; Cell Line, Tumor; Cystine; Down-Regulation; Glioma; Glutamic Acid; Humans; Mice; Rats; Receptors, AMPA; Signal Transduction; Transfection | 2011 |
Dopaminergic neurons of system x(c)⁻-deficient mice are highly protected against 6-hydroxydopamine-induced toxicity.
Topics: Aging; Amino Acid Transport System y+; Animals; Corpus Striatum; Cystine; Dopamine; Glioma; Glutamic Acid; Glutathione; Mice; Mice, Knockout; Neurodegenerative Diseases; Neurons; Oxidopamine; Substantia Nigra; Tumor Cells, Cultured | 2011 |
A negative correlation between expression profiles of runt-related transcription factor-2 and cystine/glutamate antiporter xCT subunit in ovariectomized mouse bone.
Topics: Amino Acid Transport System y+; Animals; Antiporters; Calcium; Cells, Cultured; Core Binding Factor Alpha 1 Subunit; Cystine; Female; Gene Expression; Gene Expression Profiling; Glutamic Acid; Luminescent Measurements; Mice; Osteoblasts; Ovariectomy; Transcription Factor AP-1 | 2011 |
System xc⁻ cystine/glutamate antiporter: an update on molecular pharmacology and roles within the CNS.
Topics: Amino Acid Transport System y+; Animals; Central Nervous System; Cystine; Gene Expression Regulation; Glutamic Acid; Substrate Specificity | 2012 |
Regulation of the system x(C)- cystine/glutamate exchanger by intracellular glutathione levels in rat astrocyte primary cultures.
Topics: Amino Acid Transport Systems; Analysis of Variance; Animals; Animals, Newborn; Antimetabolites; Astrocytes; Buthionine Sulfoximine; Cells, Cultured; Cerebral Cortex; Cyclic CMP; Cystine; Glutamic Acid; Glutathione; NF-E2-Related Factor 2; Rats; Reactive Oxygen Species; RNA, Messenger; Tritium | 2011 |
Increased expression of cystine/glutamate antiporter in multiple sclerosis.
Topics: Adult; Aged; Aged, 80 and over; Amino Acid Transport System y+; Amino Acid Transport Systems, Acidic; Animals; Cell Line; Cystine; Encephalomyelitis, Autoimmune, Experimental; Female; Glutamic Acid; Glutathione; Homeostasis; Humans; Inflammation; Male; Middle Aged; Multiple Sclerosis; Optic Nerve; Rats; Rats, Inbred Lew; Spinal Cord; Young Adult | 2011 |
Insulin-like growth factor 1 and transforming growth factor-β stimulate cystine/glutamate exchange activity in dental pulp cells.
Topics: Amino Acid Transport System y+; Antimetabolites; Antioxidants; Buthionine Sulfoximine; Cells, Cultured; Composite Resins; Cystine; Dental Pulp; Glutamic Acid; Glutathione; Humans; Insulin-Like Growth Factor I; Pulp Capping and Pulpectomy Agents; Transforming Growth Factor beta | 2011 |
Plasma L-cystine/L-glutamate imbalance increases tumor necrosis factor-alpha from CD14+ circulating monocytes in patients with advanced cirrhosis.
Topics: Adult; Aged; Aged, 80 and over; Amino Acid Transport System y+; Biological Transport; Cell Line; Cell Line, Tumor; Cells, Cultured; Cystine; Dose-Response Relationship, Drug; Female; Glutamic Acid; Glutathione; Glutathione Disulfide; Humans; Interleukin-10; Jurkat Cells; Linear Models; Lipopolysaccharide Receptors; Liver Cirrhosis; Male; Middle Aged; Monocytes; Reverse Transcriptase Polymerase Chain Reaction; Tumor Necrosis Factor-alpha | 2011 |
System x(c)(-) regulates microglia and macrophage glutamate excitotoxicity in vivo.
Topics: Animals; Cystine; Disease Models, Animal; Excitatory Amino Acid Antagonists; Excitatory Amino Acids; Gene Expression Regulation; Glutamic Acid; Glutathione; Laser Capture Microdissection; Lipopolysaccharides; Macrophages; Mice; Mice, Inbred C57BL; Microglia; Nerve Tissue Proteins; Neurons; Oxidation-Reduction; Quinoxalines; Spinal Cord Diseases | 2012 |
The effect of N-acetylcysteine in the nucleus accumbens on neurotransmission and relapse to cocaine.
Topics: Acetylcysteine; Animals; Cocaine; Cystine; Drug-Seeking Behavior; Excitatory Postsynaptic Potentials; Free Radical Scavengers; Glutamic Acid; Male; Nucleus Accumbens; Patch-Clamp Techniques; Prefrontal Cortex; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; Recurrence; Synaptic Transmission | 2012 |
The cystine/glutamate antiporter regulates the functional expression of indoleamine 2,3-dioxygenase in human dendritic cells.
Topics: Amino Acid Transport System y+; Cell Differentiation; Cells, Cultured; Cystine; Dendritic Cells; Gene Expression; Glutamic Acid; Glutathione; Homocysteine; Humans; Immune Tolerance; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; Lipopolysaccharides; RNA, Messenger | 2012 |
Microwave accelerated synthesis of isoxazole hydrazide inhibitors of the system xc- transporter: Initial homology model.
Topics: Amino Acid Transport System y+; Cell Line; Cystine; Glutamic Acid; Humans; Isoxazoles; Microwaves; Molecular Docking Simulation; Structural Homology, Protein | 2013 |
Canine amino acid transport system Xc(-): cDNA sequence, distribution and cystine transport activity in lens epithelial cells.
Topics: Amino Acid Sequence; Amino Acid Transport Systems, Basic; Animals; Base Sequence; Blotting, Western; Cystine; DNA Primers; DNA, Complementary; Dogs; Fusion Regulatory Protein 1, Heavy Chain; Glutamic Acid; Lens, Crystalline; Molecular Sequence Data; Reverse Transcriptase Polymerase Chain Reaction; Sequence Analysis, DNA | 2014 |
FGF-2 induces neuronal death through upregulation of system xc-.
Topics: Amino Acid Transport Systems; Animals; Cell Death; Cells, Cultured; Cystine; Fibroblast Growth Factor 2; Glutamic Acid; Mice; Neuroglia; Neurons; Receptors, AMPA; Receptors, Kainic Acid; Up-Regulation | 2014 |
Pharmacological inhibition of cystine-glutamate exchange induces endoplasmic reticulum stress and ferroptosis.
Topics: 20-Hydroxysteroid Dehydrogenases; Amino Acid Transport System y+; Apoptosis; Biomarkers; Cell Line; Cell Line, Tumor; Cell Proliferation; Cell Separation; Cystine; Endoplasmic Reticulum Stress; Glutamic Acid; Humans; Iron; Niacinamide; Phenylurea Compounds; Piperazines; Protein Kinase Inhibitors; Sequence Analysis, RNA; Sorafenib; Structure-Activity Relationship; Transcriptome; Up-Regulation | 2014 |
Stress-induced inhibition of nonsense-mediated RNA decay regulates intracellular cystine transport and intracellular glutathione through regulation of the cystine/glutamate exchanger SLC7A11.
Topics: Amino Acid Transport System y+; Biological Transport; Cell Hypoxia; Cell Line, Tumor; Cells, Cultured; Cystine; Glutamic Acid; Glutathione; HCT116 Cells; Humans; Hypoxia; Immunoblotting; Intracellular Space; Oxidative Stress; Reverse Transcriptase Polymerase Chain Reaction; RNA Stability; RNA, Messenger; Tumor Microenvironment; Up-Regulation | 2015 |
[Advance in the researches of cystine-glutamate antiporter].
Topics: Antiporters; Cystine; Glutamic Acid | 2014 |
Signal transducer and activator of transcription 3 and 5 regulate system Xc- and redox balance in human breast cancer cells.
Topics: Breast Neoplasms; Cell Line, Tumor; Cystine; Female; Glutamic Acid; Glutathione; Humans; Oxidation-Reduction; Promoter Regions, Genetic; Reactive Oxygen Species; RNA, Messenger; RNA, Small Interfering; Signal Transduction; STAT3 Transcription Factor; STAT5 Transcription Factor; Transcriptional Activation; Tumor Suppressor Proteins; Up-Regulation | 2015 |
Loss of cysteinyl-tRNA synthetase (CARS) induces the transsulfuration pathway and inhibits ferroptosis induced by cystine deprivation.
Topics: Amino Acyl-tRNA Synthetases; Animals; Antineoplastic Agents; Apoptosis; Biosynthetic Pathways; Cystine; Drug Resistance, Neoplasm; Gene Knockdown Techniques; Glutamic Acid; Humans; PC12 Cells; Piperazines; Rats; Reactive Oxygen Species; Serine; Signal Transduction | 2016 |
High-Throughput Assay Development for Cystine-Glutamate Antiporter (xc-) Highlights Faster Cystine Uptake than Glutamate Release in Glioma Cells.
Topics: Amino Acid Transport System y+; Benzoates; Brain Neoplasms; Cell Line, Tumor; Cystine; Databases, Chemical; Gene Expression Regulation, Neoplastic; Glioma; Glutamic Acid; Glycine; High-Throughput Screening Assays; Humans; Inhibitory Concentration 50; Models, Biological; RNA, Messenger; Sulfasalazine; Time Factors | 2015 |
Immunotargeting of Antigen xCT Attenuates Stem-like Cell Behavior and Metastatic Progression in Breast Cancer.
Topics: Amino Acid Transport Systems; Animals; Antigens, Neoplasm; Breast Neoplasms; Cancer Vaccines; Cell Line, Tumor; Cystine; Disease Progression; Female; Glutamic Acid; Humans; Lung Neoplasms; Mice; Mice, Inbred BALB C; Mice, Knockout; Neoplastic Stem Cells; NIH 3T3 Cells; Up-Regulation; Vaccines, DNA; Xenograft Model Antitumor Assays | 2016 |
Pituitary Adenylate cyclase-activating polypeptide orchestrates neuronal regulation of the astrocytic glutamate-releasing mechanism system xc (.).
Topics: Amino Acid Transport Systems, Acidic; Animals; Astrocytes; Cystine; Female; Glutamic Acid; Neurons; Pituitary Adenylate Cyclase-Activating Polypeptide; Pregnancy; Rats; Rats, Sprague-Dawley; Receptors, Pituitary Adenylate Cyclase-Activating Polypeptide; Synaptic Transmission; Up-Regulation | 2016 |
Functional interactions of the cystine/glutamate antiporter, CD44v and MUC1-C oncoprotein in triple-negative breast cancer cells.
Topics: Amino Acid Sequence; Amino Acid Transport System y+; Cell Proliferation; Cystine; Female; Glutamic Acid; Humans; Hyaluronan Receptors; Mucin-1; Oxidation-Reduction; Promoter Regions, Genetic; Reactive Oxygen Species; Triple Negative Breast Neoplasms; Tumor Cells, Cultured | 2016 |
The EGF Receptor Promotes the Malignant Potential of Glioma by Regulating Amino Acid Transport System xc(-).
Topics: Amino Acid Transport System y+; Animals; Antioxidants; Apoptosis; Brain Neoplasms; Cell Membrane; Cell Movement; Cell Proliferation; Cystine; ErbB Receptors; Gene Expression Regulation, Neoplastic; Glioma; Glutamic Acid; Humans; Mice; Mice, Inbred NOD; Mice, Nude; Mice, SCID; Reactive Oxygen Species; Sulfasalazine; Tumor Cells, Cultured; Xenograft Model Antitumor Assays | 2016 |
Hijacking microglial glutathione by inorganic arsenic impels bystander death of immature neurons through extracellular cystine/glutamate imbalance.
Topics: Amino Acid Transport System y+; Animals; Arsenic; Cell Line; Cell Survival; Cells, Cultured; Coculture Techniques; Cystine; Female; Gene Expression Regulation, Neoplastic; Glutamic Acid; Glutathione; Male; Mice; Microglia; Neurons; Reactive Oxygen Species | 2016 |
Characterization of the cystine/glutamate antiporter in cultured Bergmann glia cells.
Topics: Amino Acid Transport System X-AG; Animals; Antiporters; Cells, Cultured; Cerebellum; Chick Embryo; Cystine; Glutamic Acid; Neuroglia | 2017 |
The glutamate/cystine xCT antiporter antagonizes glutamine metabolism and reduces nutrient flexibility.
Topics: Amino Acid Transport System y+; Antioxidants; Biological Transport; Cell Line, Tumor; Cell Survival; Culture Media; Cystine; Epithelial Cells; Gene Expression Regulation, Neoplastic; Glucose; Glutamic Acid; Glutamine; HEK293 Cells; HeLa Cells; Humans; Mitochondria; NF-E2-Related Factor 2; Oxidative Phosphorylation; Signal Transduction | 2017 |
Oncogenic PI3K promotes methionine dependency in breast cancer cells through the cystine-glutamate antiporter xCT.
Topics: Amino Acid Transport System y+; Breast Neoplasms; Carcinogenesis; Cell Line; Cell Proliferation; Class I Phosphatidylinositol 3-Kinases; Cysteine; Cystine; Female; Gene Expression; Glutamic Acid; Homocysteine; Humans; Mammary Glands, Human; MCF-7 Cells; Methionine; Mutation | 2017 |
Sulfasalazine, an inhibitor of the cystine-glutamate antiporter, reduces DNA damage repair and enhances radiosensitivity in murine B16F10 melanoma.
Topics: Animals; Antiporters; Cell Cycle; Cell Survival; Comet Assay; Cystine; DNA Damage; DNA Repair; Female; Fibroblasts; Glutamic Acid; Hydrogen Peroxide; Melanoma, Experimental; Mice; Mice, Inbred C57BL; Oxidative Stress; Radiation Tolerance; Reactive Oxygen Species; RNA Interference; RNA, Small Interfering; Sulfasalazine; X-Rays | 2018 |
Prometheus revisited.
Topics: Animals; Antiporters; Cystine; Glutamic Acid; Hepatectomy; Hepatocytes; Liver; Liver Regeneration | 2018 |
Microglial glutamate release evoked by α-synuclein aggregates is prevented by dopamine.
Topics: Adenosine Triphosphate; alpha-Synuclein; Animals; Animals, Newborn; Antibodies, Monoclonal; Carbon Isotopes; Cells, Cultured; Cystine; Dopamine; Glutamic Acid; Humans; Lipopeptides; Lipopolysaccharides; Mice; Microglia; Platelet Aggregation Inhibitors; Protein Aggregates; Reactive Oxygen Species; Signal Transduction; Toll-Like Receptor 2 | 2018 |
The cystine/glutamate antiporter xCT is a key regulator of EphA2 S897 phosphorylation under glucose-limited conditions.
Topics: Amino Acid Transport System y+; Antiporters; Cell Line, Tumor; Cell Movement; Cell Survival; Cystine; Gene Expression Regulation, Neoplastic; Glioblastoma; Glucose; Glutamic Acid; Humans; MAP Kinase Signaling System; Phosphorylation; Reactive Oxygen Species; Receptor, EphA2; Serine | 2019 |
Coping With the Stress of Metaplasia.
Topics: Adaptation, Psychological; Antiporters; Cell Plasticity; Cystine; Glutamic Acid; Humans; Metaplasia | 2019 |
In silico characterization of residues essential for substrate binding of human cystine transporter, xCT.
Topics: Amino Acid Sequence; Amino Acid Transport System y+; Amino Acids; Computer Simulation; Cystine; Glutamic Acid; Humans; Ligands; Membrane Transport Proteins; Protein Structure, Secondary; Sequence Homology, Amino Acid | 2019 |
Hydrogen peroxide triggers an increase in cell surface expression of system x
Topics: Amino Acid Transport System y+; Cell Membrane; Cystine; Glioma; Glutamic Acid; Glutathione; Humans; Hydrogen Peroxide; Oxidative Stress | 2020 |
A synthetic lethal drug combination mimics glucose deprivation-induced cancer cell death in the presence of glucose.
Topics: Amino Acid Transport System y+; Antineoplastic Combined Chemotherapy Protocols; Antiporters; Cell Death; Cell Line, Tumor; Cell Survival; Cysteine; Cystine; Dimerization; Glucose; Glucose Transporter Type 1; Glutamic Acid; Glutathione; Humans; Metabolome; NADP; Neoplasms; Oxidation-Reduction; Reactive Oxygen Species; Synthetic Drugs | 2020 |
Iron dyshomeostasis, lipid peroxidation and perturbed expression of cystine/glutamate antiporter in Alzheimer's disease: Evidence of ferroptosis.
Topics: Alzheimer Disease; Antiporters; Cystine; Ferroptosis; Glutamic Acid; Humans; Iron; Lipid Peroxidation; Male | 2020 |
Corticostriatal dysfunction and social interaction deficits in mice lacking the cystine/glutamate antiporter.
Topics: Animals; Antiporters; Autism Spectrum Disorder; Cystine; Glutamic Acid; Mice; Proteomics; Social Interaction | 2021 |
Susceptibility to extinction and reinstatement of ethanol-induced conditioned place preference is related to differences in astrocyte cystine-glutamate antiporter content.
Topics: Animals; Antiporters; Astrocytes; Cystine; Drug-Seeking Behavior; Ethanol; Glutamic Acid; Male; Mice | 2021 |
Substitution of high-dose sucrose with fructose in high-fat diets resulted in higher plasma concentrations of aspartic acid, cystine, glutamic acid, ornithine and phenylalanine, and higher urine concentrations of arginine and citrulline.
Topics: Amino Acids; Animals; Arginine; Aspartic Acid; Blood Glucose; Citrulline; Cystine; Diet, High-Fat; Dietary Sucrose; Dietary Sugars; Fructose; Glutamic Acid; Lipids; Male; Ornithine; Phenylalanine; Rats; Rats, Wistar | 2020 |
Dysregulated Glutamate Transporter SLC1A1 Propels Cystine Uptake via Xc
Topics: Animals; Antiporters; Cell Death; Cell Line, Tumor; Cystine; Excitatory Amino Acid Transporter 3; Glutamic Acid; Glutamine; Glutathione; Lung Neoplasms; Mice; Mice, Nude; Oxidative Stress; Receptors, G-Protein-Coupled; Stress, Physiological; Up-Regulation | 2021 |
The inhibition of spermatic cystine/glutamate antiporter xCT (SLC7A11) influences the ability of cryopreserved stallion sperm to bind to heterologous zonae pellucidae.
Topics: Amino Acid Transport System y+; Animals; Antiporters; Cryopreservation; Cystine; Glutamic Acid; Horses; Male; Semen Preservation; Sperm Motility; Spermatozoa; Swine | 2021 |
Cystine-glutamate antiporter deletion accelerates motor recovery and improves histological outcomes following spinal cord injury in mice.
Topics: Amino Acid Transport System y+; Animals; Cystine; Glutamic Acid; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Motor Neurons; Recovery of Function; Spinal Cord Injuries | 2021 |
Early Onset of Age-Related Cataracts in Cystine/Glutamate Antiporter Knockout Mice.
Topics: Aging; Animals; Antiporters; Aqueous Humor; Cataract; Cystine; Glutamic Acid; Lens, Crystalline; Mice; Mice, Inbred C57BL; Mice, Knockout; Microscopy, Confocal; Oxidation-Reduction; Oxidative Stress; Slit Lamp Microscopy | 2021 |
Molecular basis for redox control by the human cystine/glutamate antiporter system xc
Topics: Amino Acid Transport System y+; Antiporters; Biochemistry; Cryoelectron Microscopy; Cysteine; Cystine; Fusion Regulatory Protein 1, Heavy Chain; Glutamic Acid; Glutathione; HEK293 Cells; Humans; Neoplasms; Oxidation-Reduction; Reactive Oxygen Species; Up-Regulation | 2021 |
Redox-dependent AMPK inactivation disrupts metabolic adaptation to glucose starvation in xCT-overexpressing cancer cells.
Topics: Amino Acid Transport System y+; AMP-Activated Protein Kinases; Cell Line, Tumor; Cystine; Glucose; Glutamic Acid; Neoplasms; Oxidation-Reduction | 2022 |
Metabolomics analysis identifies glutamic acid and cystine imbalances in COVID-19 patients without comorbid conditions. Implications on redox homeostasis and COVID-19 pathophysiology.
Topics: Amino Acids; COVID-19; Cystine; Gas Chromatography-Mass Spectrometry; Glutamic Acid; Glutamine; Homeostasis; Humans; Hypoxia; Male; Oxidation-Reduction; Oxygen; Proline; Reactive Oxygen Species; SARS-CoV-2 | 2022 |
PNO1 inhibits autophagy-mediated ferroptosis by GSH metabolic reprogramming in hepatocellular carcinoma.
Topics: Autophagy; Carcinoma, Hepatocellular; Cystine; Ferroptosis; Glutamic Acid; Glutathione; Humans; Liver Neoplasms; RNA-Binding Proteins | 2022 |
Early onset of age-related changes in the retina of cystine/glutamate antiporter knockout mice.
Topics: Animals; Cystine; Glutamic Acid; Mice; Mice, Inbred C57BL; Mice, Knockout; Retina; Retinal Pigment Epithelium | 2023 |
Cystine/glutamate antiporter System x
Topics: Animals; Antiporters; Cystine; Glutamic Acid; Glutathione; Insulin Secretion; Mice; Mice, Knockout | 2023 |
Glutaredoxin attenuates glutathione levels via deglutathionylation of Otub1 and subsequent destabilization of system x
Topics: Biological Transport; Cystine; Glutamic Acid; Glutaredoxins; Glutathione | 2023 |
Cystine/Glutamate antiporter system xc- deficiency impairs macrophage glutathione metabolism and cytokine production.
Topics: Amino Acid Transport System y+; Antiporters; Cystine; Cytokines; Glutamic Acid; Glutathione; Macrophages, Peritoneal | 2023 |
Design, synthesis, and characterization of novel system x
Topics: Antiporters; Cystine; Glutamic Acid; Humans; Microglia; Neuroinflammatory Diseases | 2023 |