cysteine has been researched along with trichloroethylene in 45 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (6.67) | 18.7374 |
| 1990's | 8 (17.78) | 18.2507 |
| 2000's | 15 (33.33) | 29.6817 |
| 2010's | 9 (20.00) | 24.3611 |
| 2020's | 10 (22.22) | 2.80 |
| Authors | Studies |
|---|---|
| Boogaard, PJ; Commandeur, JN; Mulder, GJ; Vermeulen, NP | 1 |
| Anders, MW; Vamvakas, S | 1 |
| Bakke, JE; Davison, KL | 1 |
| Lock, EA; Schnellmann, RG | 1 |
| Berthold, K; Dekant, W; Henschler, D; Schmidt, S; Vamvakas, S; Wild, D | 1 |
| Bonhaus, DW; Gandolfi, AJ | 1 |
| Bull, RJ; Eyre, RJ; Parker, JC; Stevens, DK | 2 |
| Bernauer, U; Birner, G; Dekant, W; Henschler, D | 1 |
| Dow, J; Ellis, MK; Foster, JR; Green, T; Odum, J | 1 |
| Cummings, BS; Lash, LH | 1 |
| Cummings, BS; Lash, LH; Novak, RF; Zangar, RC | 1 |
| DeGroot, DE; DuTeaux, SB; Hengel, MJ; Jelks, KA; Miller, MG | 1 |
| Bünger, J; Dreessen, B; Hallier, E; Müller, M; Westphal, G | 1 |
| RUNDLES, W | 1 |
| Horwitz, BP; Hueni, SE; Lash, LH; Putt, DA | 1 |
| Dekant, W; Everitt, JI; Mally, A; Vamvakas, S; Walker, CL | 1 |
| Argraves, SW; Barth, JL; Lock, EA; Schnellmann, RG | 1 |
| Caldwell, JC; Keshava, N | 1 |
| Hueni, SE; Lash, LH; Payton, SG; Putt, DA; Zwickl, J | 1 |
| Clay, P | 1 |
| Berger, T; Wu, KL | 1 |
| Collins, LB; Kim, D; Kim, S; Pollack, GM; Rusyn, I | 1 |
| Ball, LM; Boysen, G; Bradford, BU; Collins, LB; Gold, A; Kim, S; Rusyn, I; Swenberg, JA | 1 |
| Barshteyn, N; Elfarra, AA | 1 |
| Elfarra, AA; Irving, RM | 2 |
| Blossom, SJ; Cooney, CA; Melnyk, SB; Rau, JL; Swearingen, CJ; Wessinger, WD | 1 |
| Ball, LM; Bodnar, WM; Bradford, BU; Collins, LB; Gold, A; Kosyk, O; Rusyn, I; Shymonyak, S; Uehara, T; Yoo, HS | 2 |
| Boldenow, E; Chames, MC; Hassan, I; Loch-Caruso, R; Xi, C | 1 |
| Hassan, I; Kumar, AM; Lash, LH; Loch-Caruso, R; Park, HR | 1 |
| Chiu, W; Furuya, S; Luo, YS; Rusyn, I | 1 |
| Bridges, D; Elkin, ER; Loch-Caruso, R | 1 |
| Bridges, D; Elkin, ER; Harris, SM; Loch-Caruso, RK | 1 |
| Elkin, ER; Harris, SM; Lash, LH; Loch-Caruso, R; Su, AL | 1 |
| Armant, DR; Bakulski, KM; Bridges, D; Colacino, JA; Elkin, ER; Kilburn, BA; Loch-Caruso, R | 1 |
| Armant, DR; Bakulski, KM; Elkin, ER; Kilburn, BA; Loch-Caruso, R; Su, AL | 1 |
| Bakulski, KM; Boldenow, E; Dou, J; Harlow, O; Harris, SM; Houskamp, E; Loch-Caruso, R; Scheeres, EC; Schellenboom, E | 1 |
| Loch-Caruso, R; Su, AL | 1 |
| Baldovini, J; Capinha, L; Carta, G; Commandeur, JNM; Dinnyes, A; Grillari, J; Holzer, AK; Jennings, P; Leist, M; Mazidi, Z; Murphy, C; Ückert, AK; van de Water, B; Zana, M; Zhang, Y | 1 |
| Colacino, J; Elkin, ER; Harris, SM; Karnovsky, A; Loch-Caruso, RK; Su, AL | 1 |
| Capinha, L; Commandeur, JNM; Jennings, P | 1 |
| Lash, LH; Loch-Caruso, R; Su, AL | 1 |
3 review(s) available for cysteine and trichloroethylene
| Article | Year |
|---|---|
Perturbation of calcium homeostasis as a link between acute cell injury and carcinogenesis in the kidney.
Topics: Animals; Calcium; Cysteine; Homeostasis; Humans; Kidney; Kidney Neoplasms; Mercuric Chloride; Trichloroethylene | 1990 |
Key issues in the modes of action and effects of trichloroethylene metabolites for liver and kidney tumorigenesis.
Topics: Animals; Carcinogenicity Tests; Chloral Hydrate; Cysteine; Dichloroacetic Acid; Environmental Pollutants; History, 21st Century; Humans; Kidney Neoplasms; Liver Neoplasms; Risk Assessment; Risk Factors; Signal Transduction; Trichloroacetic Acid; Trichloroethylene; United States | 2006 |
Role of reactive metabolites in the circulation in extrahepatic toxicity.
Topics: Acetylcysteine; Cysteine; Humans; Kidney; Liver; Trichloroethylene | 2012 |
42 other study(ies) available for cysteine and trichloroethylene
| Article | Year |
|---|---|
Mutagenicity and cytotoxicity of two regioisomeric mercapturic acids and cysteine S-conjugates of trichloroethylene.
Topics: Acetylcysteine; Animals; Cysteine; In Vitro Techniques; Kidney Tubules, Proximal; Male; Mutagenicity Tests; Mutagens; Rats; Rats, Inbred Strains; Salmonella typhimurium; Stereoisomerism; Trichloroethylene | 1991 |
Elimination of 14C by calves, pigs and rats renally perfused with radiolabelled dichlorovinyl or acetamide substrates.
Topics: Acetanilides; Acetylation; Acetylcysteine; Animals; Carbon Radioisotopes; Cattle; Cysteine; Herbicides; Iodoacetamide; Kidney; Perfusion; Rats; Rats, Inbred Strains; Swine; Trichloroethylene | 1990 |
The effect of haloalkene cysteine conjugates on rat renal glutathione reductase and lipoyl dehydrogenase activities.
Topics: Animals; Butadienes; Cysteine; Cytosol; Dihydrolipoamide Dehydrogenase; Female; Fluorocarbons; Glutathione Reductase; Kidney; Kidney Cortex; Liver; Male; Mitochondria; Rats; Trichloroethylene | 1990 |
Bacterial beta-lyase mediated cleavage and mutagenicity of cysteine conjugates derived from the nephrocarcinogenic alkenes trichloroethylene, tetrachloroethylene and hexachlorobutadiene.
Topics: Animals; Biotransformation; Butadienes; Carbon-Sulfur Lyases; Cysteine; Kidney; Lyases; Male; Microsomes; Microsomes, Liver; Mutagenicity Tests; Mutagens; Mutation; Rats; Rats, Inbred Strains; Salmonella typhimurium; Structure-Activity Relationship; Tetrachloroethylene; Trichloroethylene | 1986 |
Conjugation and bioactivation of chlorotrifluoroethylene.
Topics: Animals; Chlorofluorocarbons; Cysteine; Glutathione; Hydrocarbons, Halogenated; Kidney; Liver; Lyases; Male; Maleates; Microvilli; Pyruvates; Pyruvic Acid; Rats; Rats, Inbred F344; Subcellular Fractions; Trichloroethylene | 1981 |
Acid-labile adducts to protein can be used as indicators of the cysteine S-conjugate pathway of trichloroethene metabolism.
Topics: Amino Acids; Animals; Biomarkers; Carbon Radioisotopes; Cysteine; Dichloroacetic Acid; Hydrolysis; Kidney; Liver; Male; Mice; Rats; Rats, Inbred F344; Species Specificity; Time Factors; Trichloroethylene | 1995 |
Renal activation of trichloroethene and S-(1,2-dichlorovinyl)-L-cysteine and cell proliferative responses in the kidneys of F344 rats and B6C3F1 mice.
Topics: Animals; Carrier Proteins; Cell Division; Cysteine; Dose-Response Relationship, Drug; Kidney; Kidney Diseases; Male; Mice; Rats; Rats, Inbred F344; Species Specificity; Trichloroethylene | 1995 |
Biotransformation of trichloroethene: dose-dependent excretion of 2,2,2-trichloro-metabolites and mercapturic acids in rats and humans after inhalation.
Topics: Acetylcysteine; Administration, Inhalation; Adult; Aged; Animals; Biotransformation; Cysteine; Dose-Response Relationship, Drug; Female; Gas Chromatography-Mass Spectrometry; Glutathione; Humans; Male; Middle Aged; Rats; Trichloroethylene | 1996 |
The role of glutathione conjugation in the development of kidney tumours in rats exposed to trichloroethylene.
Topics: Animals; Arylamine N-Acetyltransferase; Carbon-Sulfur Lyases; Chromatography, High Pressure Liquid; Cysteine; Glutathione; Humans; In Vitro Techniques; Isomerism; Kidney; Kidney Neoplasms; Kinetics; Lyases; Male; Mice; Rats; Rats, Inbred F344; Trichloroethylene | 1997 |
Metabolism and toxicity of trichloroethylene and S-(1,2-dichlorovinyl)-L-cysteine in freshly isolated human proximal tubular cells.
Topics: Adult; Aged; Aminooxyacetic Acid; Chloral Hydrate; Cysteine; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Enzyme Inhibitors; Female; Glutathione; Humans; Kidney Tubules, Proximal; L-Lactate Dehydrogenase; Male; Metyrapone; Microsomes; Middle Aged; Trichloroethylene | 2000 |
Cytotoxicity of trichloroethylene and S-(1, 2-dichlorovinyl)-L-cysteine in primary cultures of rat renal proximal tubular and distal tubular cells.
Topics: Animals; Cells, Cultured; Cysteine; Cytochrome P-450 Enzyme System; DNA; Isoenzymes; Keratins; Kidney Tubules, Distal; Kidney Tubules, Proximal; L-Lactate Dehydrogenase; Male; Rats; Rats, Inbred F344; RNA, Messenger; Trichloroethylene; Vimentin | 2000 |
Cutaneous drug reaction case reports: from the world literature.
Topics: Adolescent; Adverse Drug Reaction Reporting Systems; Aged; Amlodipine; Anti-Bacterial Agents; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Anticoagulants; Anticonvulsants; Antihypertensive Agents; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Antirheumatic Agents; BCG Vaccine; Cefotetan; Cephamycins; Contrast Media; Cysteine; Dapsone; Diltiazem; Dipyrone; Docetaxel; Drug Eruptions; Echinacea; Enoxaparin; Female; Fructose; Glucans; Glucose; Gold Sodium Thiomalate; Humans; Ibuprofen; Icodextrin; Ioxaglic Acid; Male; Middle Aged; Minocycline; Paclitaxel; Pregnancy; Solvents; Taxoids; Topiramate; Triamcinolone; Trichloroethylene | 2001 |
Evidence for trichloroethylene bioactivation and adduct formation in the rat epididymis and efferent ducts.
Topics: Animals; Biotransformation; Cysteine; Cytochrome P-450 CYP2E1; DNA Adducts; Dose-Response Relationship, Drug; Environmental Pollutants; Epididymis; Immunohistochemistry; Lyases; Male; Protein Binding; Rats; Rats, Sprague-Dawley; Solvents; Transaminases; Trichloroethylene; Vas Deferens | 2003 |
Mutagenicity of the glutathione and cysteine S-conjugates of the haloalkenes 1,1,2-trichloro-3,3,3-trifluoro-1-propene and trichlorofluoroethene in the Ames test in comparison with the tetrachloroethene-analogues.
Topics: Chlorofluorocarbons; Cysteine; Glutathione; Mutagenicity Tests; Mutagens; Salmonella typhimurium; Tetrachloroethylene; Trichloroethylene | 2003 |
Toxic protein derivatives causing aplastic anemia; a review.
Topics: Anemia; Anemia, Aplastic; Cysteine; Glycine max; Humans; Trichloroethylene | 1958 |
Molecular markers of trichloroethylene-induced toxicity in human kidney cells.
Topics: Apoptosis; Biomarkers; Cell Proliferation; Cells, Cultured; Cysteine; Humans; Kidney Tubules, Proximal; Necrosis; Signal Transduction; Trichloroethylene | 2005 |
Analysis of renal cell transformation following exposure to trichloroethene in vivo and its metabolite S-(dichlorovinyl)-L-cysteine in vitro.
Topics: Animals; Carcinogenicity Tests; Carcinogens; Carcinoma, Renal Cell; Cell Proliferation; Cell Transformation, Neoplastic; Cysteine; DNA; DNA Mutational Analysis; Gene Expression Regulation, Neoplastic; Kidney; Kidney Cortex; Kidney Diseases; Kidney Neoplasms; Loss of Heterozygosity; Male; Precancerous Conditions; Rats; Rats, Inbred Strains; Reverse Transcriptase Polymerase Chain Reaction; Solvents; Trichloroethylene | 2006 |
Changes in gene expression in human renal proximal tubule cells exposed to low concentrations of S-(1,2-dichlorovinyl)-l-cysteine, a metabolite of trichloroethylene.
Topics: Adenosine Kinase; Adolescent; Adult; Aged; Arylamine N-Acetyltransferase; Cell Survival; Complement Factor H; Cysteine; DNA; DNA-Binding Proteins; Dose-Response Relationship, Drug; Environmental Pollutants; Female; Gene Expression; Gene Expression Profiling; Glucose; Glutathione; Humans; In Vitro Techniques; Isoenzymes; Kidney Tubules, Proximal; Kruppel-Like Transcription Factors; Lyases; Male; Middle Aged; RNA, Messenger; Transcription Factors; Trichloroethylene | 2006 |
Interactive toxicity of inorganic mercury and trichloroethylene in rat and human proximal tubules: effects on apoptosis, necrosis, and glutathione status.
Topics: Adaptation, Physiological; Animals; Apoptosis; Cells, Cultured; Cysteine; Drug Administration Schedule; Drug Interactions; Environmental Pollutants; Glutathione; Glutathione Transferase; Humans; Kidney Tubules, Proximal; Male; Mercury; Necrosis; Rats; Rats, Inbred F344; Time Factors; Trichloroethylene | 2007 |
Assessment of the genotoxicity of trichloroethylene and its metabolite, S-(1,2-dichlorovinyl)-L-cysteine (DCVC), in the comet assay in rat kidney.
Topics: Animals; Cells, Cultured; Comet Assay; Cysteine; DNA; DNA Damage; Dose-Response Relationship, Drug; Kidney Tubules, Proximal; Male; Mutagens; Rats; Rats, Sprague-Dawley; Solvents; Trichloroethylene | 2008 |
Reduction in rat oocyte fertilizability mediated by S-(1, 2-dichlorovinyl)-L-cysteine: a trichloroethylene metabolite produced by the glutathione conjugation pathway.
Topics: Animals; Biotransformation; Body Weight; Cysteine; Female; Fertilization in Vitro; Glutathione; Immunohistochemistry; In Vitro Techniques; Male; Oocytes; Rats; Rats, Sprague-Dawley; Reproduction; Solvents; Trichloroethylene | 2008 |
Pharmacokinetic analysis of trichloroethylene metabolism in male B6C3F1 mice: Formation and disposition of trichloroacetic acid, dichloroacetic acid, S-(1,2-dichlorovinyl)glutathione and S-(1,2-dichlorovinyl)-L-cysteine.
Topics: Administration, Oral; Animals; Biological Availability; Carcinogens; Cysteine; Dichloroacetic Acid; Glutathione; Half-Life; Male; Mice; Models, Biological; Oxidation-Reduction; Risk Assessment; Time Factors; Trichloroacetic Acid; Trichloroethylene | 2009 |
Liquid chromatography electrospray ionization tandem mass spectrometry analysis method for simultaneous detection of trichloroacetic acid, dichloroacetic acid, S-(1,2-dichlorovinyl)glutathione and S-(1,2-dichlorovinyl)-L-cysteine.
Topics: Animals; Chromatography, High Pressure Liquid; Cysteine; Dichloroacetic Acid; Glutathione; Male; Mice; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry; Trichloroacetic Acid; Trichloroethylene | 2009 |
Globin monoadducts and cross-links provide evidence for the presence of S-(1,2-dichlorovinyl)-L-cysteine sulfoxide, chlorothioketene, and 2-chlorothionoacetyl chloride in the circulation in rats administered S-(1,2-dichlorovinyl)-L-cysteine.
Topics: Amino Acid Sequence; Animals; Chromatography, High Pressure Liquid; Cross-Linking Reagents; Cysteine; Erythrocytes; Globins; Male; Molecular Sequence Data; Peptides; Rats; Rats, Sprague-Dawley; Spectrometry, Mass, Electrospray Ionization; Thiones; Trichloroethylene; Trypsin | 2009 |
Mutagenicity of the cysteine S-conjugate sulfoxides of trichloroethylene and tetrachloroethylene in the Ames test.
Topics: Carbon-Sulfur Lyases; Cysteine; Mutagenicity Tests; Oxamic Acid; Tetrachloroethylene; Trichloroethylene | 2013 |
Metabolic changes and DNA hypomethylation in cerebellum are associated with behavioral alterations in mice exposed to trichloroethylene postnatally.
Topics: Animals; Animals, Newborn; Behavior, Animal; Cerebellum; Cysteine; DNA Methylation; Glutathione; Male; Mice; Mice, Inbred MRL lpr; Oxidation-Reduction; Oxidative Stress; Trichloroethylene; Tyrosine | 2013 |
Comparative analysis of the relationship between trichloroethylene metabolism and tissue-specific toxicity among inbred mouse strains: liver effects.
Topics: Administration, Oral; Animals; Carcinogens; Cell Proliferation; Cysteine; Cytochrome P-450 Enzyme System; Dichloroacetic Acid; Dose-Response Relationship, Drug; Ethylene Chlorohydrin; Gene Expression; Glutathione; Hepatocytes; Liver; Male; Mice; Mice, Inbred C57BL; Mice, Inbred Strains; Oxidation-Reduction; Oxidative Stress; Real-Time Polymerase Chain Reaction; Solvents; Trichloroacetic Acid; Trichloroethylene | 2015 |
Comparative analysis of the relationship between trichloroethylene metabolism and tissue-specific toxicity among inbred mouse strains: kidney effects.
Topics: Animals; Carcinogens; Cell Proliferation; Cysteine; Cytochrome P-450 Enzyme System; Dichloroacetic Acid; Ethylene Chlorohydrin; Glutathione; Hepatitis A Virus Cellular Receptor 1; Kidney; Male; Membrane Proteins; Mice; Mice, Inbred C57BL; Mice, Inbred Strains; Oxidation-Reduction; PPAR alpha; Trichloroacetic Acid; Trichloroethylene | 2015 |
The trichloroethylene metabolite S-(1,2-dichlorovinyl)-l-cysteine but not trichloroacetate inhibits pathogen-stimulated TNF-α in human extraplacental membranes in vitro.
Topics: Chorion; Cysteine; Decidua; Disease Resistance; Extraembryonic Membranes; Female; Humans; Immunity; Lipopolysaccharides; Pregnancy; Streptococcal Infections; Streptococcus agalactiae; Teichoic Acids; Tissue Culture Techniques; Trichloroacetic Acid; Trichloroethylene; Tumor Necrosis Factor-alpha | 2015 |
Reactive Oxygen Stimulation of Interleukin-6 Release in the Human Trophoblast Cell Line HTR-8/SVneo by the Trichlorethylene Metabolite S-(1,2-Dichloro)-l-Cysteine.
Topics: Cell Line, Transformed; Cysteine; Female; Humans; Interleukin-6; Membrane Potential, Mitochondrial; Oxidative Stress; Placenta; Pregnancy; Reactive Oxygen Species; Trichloroethylene; Trophoblasts | 2016 |
Characterization of inter-tissue and inter-strain variability of TCE glutathione conjugation metabolites DCVG, DCVC, and NAcDCVC in the mouse.
Topics: Acetylcysteine; Animals; Cysteine; Glutathione; Liver; Male; Mice; Mice, Inbred Strains; Signal-To-Noise Ratio; Tissue Distribution; Trichloroethylene | 2018 |
The trichloroethylene metabolite S-(1,2-dichlorovinyl)-L-cysteine induces progressive mitochondrial dysfunction in HTR-8/SVneo trophoblasts.
Topics: Cell Line; Cysteine; DNA, Mitochondrial; Humans; Membrane Potential, Mitochondrial; Mitochondria; Oxygen Consumption; Trichloroethylene; Trophoblasts | 2019 |
Exposure to Trichloroethylene Metabolite
Topics: Amino Acids; AMP-Activated Protein Kinases; Cell Line; Cell Survival; Cysteine; Energy Metabolism; Glucose; Glycerol; Humans; Lipid Metabolism; Nutrients; Phosphofructokinase-1; Solvents; Trichloroethylene | 2020 |
Placenta as a target of trichloroethylene toxicity.
Topics: Child; Cysteine; Female; Humans; Male; Oxidative Stress; Placenta; Pregnancy; Solvents; Trichloroethylene | 2020 |
Transcriptional profiling of the response to the trichloroethylene metabolite S-(1,2-dichlorovinyl)-L-cysteine revealed activation of the eIF2α/ATF4 integrated stress response in two in vitro placental models.
Topics: Activating Transcription Factor 4; Cell Line; Cells, Cultured; Cysteine; Eukaryotic Initiation Factor-2; Female; Humans; Kidney Tubules, Proximal; Placenta; Pregnancy; Solvents; Trichloroethylene; Trophoblasts | 2021 |
Toxicity assessments of selected trichloroethylene and perchloroethylene metabolites in three in vitro human placental models.
Topics: Cysteine; Female; Humans; Placenta; Pregnancy; Solvents; Tetrachloroethylene; Trichloroethylene | 2022 |
The trichloroethylene metabolite S-(1,2-dichlorovinyl)-l-cysteine inhibits lipopolysaccharide-induced inflammation transcriptomic pathways and cytokine secretion in a macrophage cell model.
Topics: Cysteine; Humans; Inflammation; Interleukin-6; Lipopolysaccharides; Macrophages; Transcriptome; Trichloroethylene; Tumor Necrosis Factor-alpha | 2022 |
Apoptotic responses stimulated by the trichloroethylene metabolite S-(1,2-dichlorovinyl)-L-cysteine depend on cell differentiation state in BeWo human trophoblast cells.
Topics: Cell Differentiation; Cysteine; Female; Humans; Hydrogen Peroxide; Placenta; Pregnancy; RNA, Messenger; Trichloroethylene; Trophoblasts | 2023 |
Transcriptomic-based evaluation of trichloroethylene glutathione and cysteine conjugates demonstrate phenotype-dependent stress responses in a panel of human in vitro models.
Topics: Cysteine; Glutathione; Humans; Induced Pluripotent Stem Cells; NF-E2-Related Factor 2; Phenotype; Transcriptome; Trichloroethylene | 2023 |
Trichloroethylene Metabolite
Topics: Amino Acids; Aspartic Acid; Colforsin; Cysteine; Female; Humans; Matrix Metalloproteinase 2; Oleic Acids; Placenta; Pregnancy; Trichloroethylene; Trophoblasts | 2023 |
Exposure to cis- and trans-regioisomers of S-(1,2-dichlorovinyl)-L-cysteine and S-(1,2-dichlorovinyl)-glutathione result in quantitatively and qualitatively different cellular effects in RPTEC/TERT1 cells.
Topics: Animals; Cysteine; Glutathione; Humans; Kidney; Rats; Trichloroethylene | 2023 |
N-Acetyl-L-cysteine and aminooxyacetic acid differentially modulate toxicity of the trichloroethylene metabolite S-(1,2-dichlorovinyl)-L-cysteine in human placental villous trophoblast BeWo cells.
Topics: Acetylcysteine; Aminooxyacetic Acid; Cysteine; Cytochrome P-450 CYP3A; Female; Humans; Hydrogen Peroxide; Placenta; Pregnancy; RNA, Messenger; Trichloroethylene; Trophoblasts | 2023 |