cysteine has been researched along with sesquiterpenes in 53 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 10 (18.87) | 18.7374 |
| 1990's | 14 (26.42) | 18.2507 |
| 2000's | 15 (28.30) | 29.6817 |
| 2010's | 13 (24.53) | 24.3611 |
| 2020's | 1 (1.89) | 2.80 |
| Authors | Studies |
|---|---|
| ElGebaly, SA; HADGRAFT, RI; Hall, IH; Lee, KH; Mar, EC; Ruffner, CG; Starnes, CO; Waddell, TG; Weidner, I | 1 |
| Picman, AK; Rodriguez, E; Towers, GH | 1 |
| Hall, IH; Lee, KH; Mar, EC; Starnes, CO; Waddell, TG | 1 |
| Hoult, JR; Knight, DW; Salan, U; Sumner, H | 1 |
| Erdman, RA; Kinsella, BT; Maltese, WA | 1 |
| Leven, W; Lösche, W; Schröder, H; Schrör, K; Strobach, H; Till, U; Willuhn, G | 1 |
| Picman, AK; Picman, J | 2 |
| Gaspar, AR; Neitz, AW; Vermeulen, NM; Verschoor, JA | 1 |
| Groenewegen, WA; Heptinstall, S; Loesche, W; Spangenberg, P | 1 |
| Baker, PM; Fortes, CC; Fortes, EG; Gazzinelli, G; Gilbert, B; Lopes, JN; Pellegrino, J; Tomassini, TC; Vichnewski, W | 1 |
| Camp, BJ; Roberts, AJ | 1 |
| Adachi, T; Haraguchi, H; Kubo, I; Oi, S; Taniguchi, M | 1 |
| Camp, BJ; Kim, HL; Rowe, LD | 1 |
| Cox, AD | 1 |
| Casey, PJ; Furfine, ES; Landavazo, A; Leban, JJ; Moomaw, JF | 1 |
| Cane, DE; Fitzsimons, BC; Hohn, TM; Shim, JH; Xue, Q | 1 |
| Hamburger, M; Hay, AJ; Hostettmann, K; Hoult, JR | 1 |
| Hatamori, N; Hayashi, Y; Hirohata, T; Kasuga, M; Mimoto, H; Mizoguchi, Y; Morita, S; Nakaoka, T; Yoshida, H; Yun, S | 1 |
| Inoue, T; Kikuchi, T; Tanaka, K; Tezuka, Y | 1 |
| Schmidt, TJ | 1 |
| Chang, YH; Griffith, EC; Liu, JO; Niwayama, S; Ramsay, CA; Su, Z | 1 |
| Lyss, G; Merfort, I; Pahl, HL; Schmidt, TJ | 1 |
| Phillips, ST; Poulter, CD; Rozema, DB | 1 |
| Bizer, C; Schapowal, A; Simon, HU; Thomet, OA; Wiesmann, UN | 1 |
| Nam, HW; Shin, JC; Son, ES; Song, KJ | 1 |
| Castro, V; García-Piñeres, AJ; Merfort, I; Mora, G; Pahl, HL; Schmidt, TJ; Strunck, E | 1 |
| Heilmann, J; Schmidt, TJ; Wasescha, MR | 1 |
| Blaser, K; Simon, HU; Thomet, OA; Wiesmann, UN | 1 |
| Estes, LA; Kelner, MJ; McMorris, TC; Rojas, RJ; Suthipinijtham, P; Trani, NA; Velasco, TR | 1 |
| Chollet, J; Gao, HF; Jiao, PY; Mei, JY; Tanner, M; Utzinger, J; Xiao, SH; You, JQ | 1 |
| Chen, YL; Wu, WM; Wu, YL; Xiao, SH; Zhai, Z | 1 |
| Ayral-Kaloustian, S; Salaski, EJ | 1 |
| García-Piñeres, AJ; Lindenmeyer, MT; Merfort, I | 1 |
| Adolph, S; Jung, V; Pohnert, G; Rattke, J | 1 |
| Andres, DA; Liu, S; Spielmann, HP; Subramanian, T; Troutman, JM | 1 |
| Cao, L; Grant, DF; Zhang, P | 1 |
| Aimiuwu, J; Bhasin, D; Chan, KK; Chen, P; Fuchs, JR; Huang, TH; Li, C; Li, PK; Liu, S; Liu, Z; Marcucci, G; Neviani, P; Pang, J; Pavlovicz, RE; Perrotti, D; Plass, C; Rush, L; Wang, H; Wu, J; Wu, LC; Xie, Z | 1 |
| Alvarez, LD; Clarêncio, J; Costa, MF; Costa, SL; El-Bachá, RS; Lima, RM | 1 |
| Liu, X; Pietsch, KE; Sturla, SJ | 1 |
| Beekwilder, J; Bouwmeester, HJ; Cankar, K; Charnikhova, T; de Vos, RC; Goedbloed, M; Liu, Q; Majdi, M; van der Krol, S; Verstappen, FW | 1 |
| Johansson, AS; Leinartaitė, L | 1 |
| Cheung, HY; Xu, L; Zhang, Z | 1 |
| Cao, R; Chen, S; Dian, L; Dong, T; He, S; Huang, N; Lei, X; Li, C; Li, L; Wang, X; Zhang, X | 1 |
| Langer, K; Plöger, M; Schmidt, TJ; Sendker, J | 1 |
| Abegg, D; Adibekian, A; Hoch, DG; Lagoutte, R; Serba, C; Winssinger, N | 1 |
| Chen, L; Ge, G; Lan, G; Liu, Q; Mao, L; Ning, J; Shen, Y; Wang, S; Yang, L; Yang, N; Ye, J; Zhang, W; Zhou, B; Zhuo, Z | 1 |
| Baur, JW; Brown, DA; Brown, TJ; Edwards, JT; Harki, DA; Kempema, AM; Meece, FA; Skopec, HM; Widen, JC | 1 |
| Amaya, Y; Dohmae, N; Jantan, I; Komatsu, T; Miyata, Y; Nakamoto, H; Nakamura, Y; Suzuki, T | 1 |
| Dörfer, M; Garscha, U; Häfner, AK; Hoffmeister, D; Hofmann, B; Karas, M; König, S; Krauth, V; Liening, S; Romp, E; Rühl, M; Steinhilber, D; Werz, O | 1 |
| Cao, Y; Chai, C; Chen, W; Huang, S; Jia, Q; Lu, Y; Ni, W; Pan, Y; Sun, Z; Wang, A; Wang, S; Wang, W; Wei, Z; Wu, Y; Yu, S; Zhang, L; Zheng, Q | 1 |
| Pedras, MSC; Thapa, C | 1 |
| Fu, XW; Han, C; Kong, LY; Liao, ST; Wang, JS; Xu, DQ | 1 |
1 review(s) available for cysteine and sesquiterpenes
| Article | Year |
|---|---|
Protein farnesyltransferase inhibitors.
Topics: Alkyl and Aryl Transferases; Angiogenesis Inducing Agents; Animals; Antineoplastic Agents; Apoptosis; Cell Membrane; Clinical Trials as Topic; Cysteine; Enzyme Inhibitors; Farnesyltranstransferase; Humans; Neoplasms; Polyisoprenyl Phosphates; Protein Prenylation; Protein Processing, Post-Translational; ras Proteins; Sesquiterpenes | 2002 |
52 other study(ies) available for cysteine and sesquiterpenes
| Article | Year |
|---|---|
Sesquiterpene antitumor agents: inhibitors of cellular metabolism.
Topics: Alkylation; Animals; Antimetabolites, Antineoplastic; Carcinoma, Ehrlich Tumor; Cholesterol; Cyclic AMP; Cysteine; DNA, Neoplasm; Glycolysis; Lactones; Male; Nucleic Acid Synthesis Inhibitors; Oxygen Consumption; Rats; RNA, Neoplasm; Sesquiterpenes; Sesquiterpenes, Guaiane; Structure-Activity Relationship; Sulfhydryl Compounds | 1977 |
Formation of adducts of parthenin and related sesquiterpene lactones with cysteine and glutathione.
Topics: Allergens; Chemical Phenomena; Chemistry; Cysteine; Glutathione; Lactones; Sesquiterpenes | 1979 |
Antitumor agents. 21. A proposed mechanism for inhibition of cancer growth by tenulin and helenalin and related cyclopentenones.
Topics: Animals; Antineoplastic Agents, Phytogenic; Ascitic Fluid; Carcinoma 256, Walker; Carcinoma, Ehrlich Tumor; Chromatin; Cyclopentanes; Cysteine; DNA, Neoplasm; Glutathione; Histidine; Lactones; Leukemia, Experimental; Leukemia, Lymphoid; Male; Mice; Mice, Inbred DBA; Neoplasm Proteins; Rats; Sesquiterpenes; Sesquiterpenes, Guaiane; Spectrophotometry, Ultraviolet; Time Factors | 1977 |
Inhibition of 5-lipoxygenase and cyclo-oxygenase in leukocytes by feverfew. Involvement of sesquiterpene lactones and other components.
Topics: Animals; Cyclooxygenase Inhibitors; Cysteine; Lactones; Leukocytes; Leukotriene B4; Lipoxygenase Inhibitors; Plant Extracts; Plants, Medicinal; Rats; Rats, Inbred Strains; Sesquiterpenes; Tanacetum parthenium; Thromboxane B2 | 1992 |
Posttranslational modification of Ha-ras p21 by farnesyl versus geranylgeranyl isoprenoids is determined by the COOH-terminal amino acid.
Topics: Amino Acid Sequence; Animals; Base Sequence; Cell Line; Cysteine; GTP-Binding Proteins; Mevalonic Acid; Molecular Sequence Data; Mutagenesis, Site-Directed; Oligonucleotides; Polyisoprenyl Phosphates; Protein Biosynthesis; Protein Processing, Post-Translational; Proto-Oncogene Proteins p21(ras); Sesquiterpenes; Transfection | 1991 |
Helenalin and 11 alpha,13-dihydrohelenalin, two constituents from Arnica montana L., inhibit human platelet function via thiol-dependent pathways.
Topics: Arachidonic Acid; Arachidonic Acids; Blood Platelets; Cysteine; Humans; Phospholipases A; Phospholipases A2; Platelet Aggregation; Platelet Aggregation Inhibitors; Serotonin; Sesquiterpenes; Sesquiterpenes, Guaiane; Sulfhydryl Reagents; Thromboxane B2 | 1990 |
Treatment of dermatitis caused by the sesquiterpene lactone helenin.
Topics: Animals; Cysteine; Dermatitis, Contact; Female; Guinea Pigs; Lactones; Sesquiterpenes; Sesquiterpenes, Eudesmane | 1990 |
The influence of the sesquiterpene lactones from Geigeria on mast cell degranulation.
Topics: Alkylation; Animals; Cysteine; Ethylmaleimide; Histamine Release; Lactones; Male; Mast Cells; p-Methoxy-N-methylphenethylamine; Plant Extracts; Rats; Rats, Inbred Strains; Sesquiterpenes; Sesquiterpenes, Guaiane; Thapsigargin | 1987 |
Extracts of feverfew may inhibit platelet behaviour via neutralization of sulphydryl groups.
Topics: Arachidonic Acid; Arachidonic Acids; Blood Platelets; Blood Protein Electrophoresis; Cysteine; Humans; In Vitro Techniques; Indicators and Reagents; Plant Extracts; Plants, Medicinal; Platelet Aggregation; Sesquiterpenes; Sulfhydryl Compounds | 1987 |
Treatment of dermatitis from parthenin.
Topics: Administration, Topical; Animals; Cysteine; Dermatitis, Contact; Female; Guinea Pigs; Sesquiterpenes | 1985 |
Chemoprophylactic agents in schistosomiasis: eremanthine, costunolide, -cyclocostunolide and bisabolol.
Topics: Alcohols; Animals; Anthelmintics; Chromatography, Gas; Chromatography, Thin Layer; Cyclohexanes; Cysteine; Lactones; Mice; Plant Extracts; Schistosomiasis; Sesquiterpenes; Spectrophotometry, Infrared; Sulfhydryl Compounds; Terpenes | 1972 |
In vitro effects of hymenoxon on phosphofructokinase.
Topics: Adenosine Triphosphate; Cysteine; Phosphofructokinase-1; Sesquiterpenes | 1984 |
Physiological activity of warburganal and its reactivity with sulfhydryl groups.
Topics: Alcohol Oxidoreductases; Antifungal Agents; Bacteria; Cysteine; Fermentation; Fungi; Kinetics; Microbial Sensitivity Tests; Saccharomyces cerevisiae; Sesquiterpenes; Sulfhydryl Compounds; Sulfhydryl Reagents; Time Factors | 1983 |
The antagonistic effect of L-cysteine in experimental hymenoxon intoxication in sheep.
Topics: Animals; Cysteine; Female; Injections, Intravenous; Sesquiterpenes; Sheep; Sheep Diseases | 1980 |
Mutation and analysis of prenylation signal sequences.
Topics: Animals; Cells, Cultured; Cloning, Molecular; Cysteine; DNA Mutational Analysis; Indicators and Reagents; Mammals; Methionine; Mevalonic Acid; Polyisoprenyl Phosphates; Polymerase Chain Reaction; Protein Biosynthesis; Protein Prenylation; Protein Sorting Signals; Rabbits; Radioisotope Dilution Technique; Recombinant Proteins; Reticulocytes; Sesquiterpenes; Sulfur Radioisotopes; Tritium | 1995 |
Protein farnesyltransferase: kinetics of farnesyl pyrophosphate binding and product release.
Topics: Alkyl and Aryl Transferases; Amino Acid Sequence; Binding Sites; Biotin; Catalysis; Cysteine; Kinetics; Molecular Sequence Data; Peptides; Polyisoprenyl Phosphates; Protein Prenylation; Sesquiterpenes; Spectrometry, Fluorescence; Transferases | 1995 |
Trichodiene synthase. Identification of active site residues by site-directed mutagenesis.
Topics: Amino Acid Sequence; Base Sequence; Binding Sites; Carbon-Carbon Lyases; Catalysis; Cloning, Molecular; Cysteine; DNA Primers; DNA, Fungal; Escherichia coli; Fusarium; Kinetics; Lyases; Methyl Methanesulfonate; Molecular Sequence Data; Molecular Structure; Mutagenesis, Site-Directed; Polyisoprenyl Phosphates; Sesquiterpenes; Substrate Specificity | 1995 |
Toxic inhibition of smooth muscle contractility by plant-derived sesquiterpenes caused by their chemically reactive alpha-methylenebutyrolactone functions.
Topics: Animals; Aorta, Thoracic; Chromatography, High Pressure Liquid; Cysteine; In Vitro Techniques; Lactones; Male; Muscle Contraction; Muscle, Smooth, Vascular; Phenylephrine; Phorbols; Plants; Rabbits; Sesquiterpenes | 1994 |
[A case of prolonged liver injury caused by low dose of acetaminophen--the involvement of other multiple drugs such as Proheparum and Mazulene-S was considered in this drug-induced hepatitis].
Topics: Acetaminophen; Adult; Azulenes; Bis-Trimethylammonium Compounds; Chemical and Drug Induced Liver Injury; Cysteine; Drug Combinations; Female; Humans; Inositol; Liver; Liver Extracts; Sesquiterpenes; Vitamin B 12 | 1993 |
Michael-type addition of illudin S, a toxic substance from Lampteromyces japonicus, with cysteine and cysteine-containing peptides in vitro.
Topics: Amino Acid Sequence; Antibiotics, Antineoplastic; Basidiomycota; Chromatography, Thin Layer; Cysteine; Glutathione; Magnetic Resonance Spectroscopy; Molecular Sequence Data; Peptides; Polycyclic Sesquiterpenes; Sesquiterpenes; Spectrophotometry, Ultraviolet | 1996 |
Helenanolide-type sesquiterpene lactones--III. Rates and stereochemistry in the reaction of helenalin and related helenanolides with sulfhydryl containing biomolecules.
Topics: Antineoplastic Agents, Phytogenic; Binding, Competitive; Cysteine; Glutathione; Magnetic Resonance Spectroscopy; Models, Molecular; Sesquiterpenes; Sesquiterpenes, Guaiane; Stereoisomerism; Structure-Activity Relationship; Toxins, Biological | 1997 |
Molecular recognition of angiogenesis inhibitors fumagillin and ovalicin by methionine aminopeptidase 2.
Topics: Amino Acid Sequence; Aminopeptidases; Animals; Anti-Bacterial Agents; Catalytic Domain; Cell Division; Cell Line; Cyclohexanes; Cysteine; Endothelium, Vascular; Fatty Acids, Unsaturated; Histidine; Humans; Metalloendopeptidases; Mutagenesis, Site-Directed; Neovascularization, Pathologic; Recombinant Proteins; Sesquiterpenes; Spodoptera; Transfection | 1998 |
Helenanolide type sesquiterpene lactones. Part 5: the role of glutathione addition under physiological conditions.
Topics: Binding Sites; Cysteine; Glutathione; Hydrogen-Ion Concentration; Kinetics; Lactones; Magnetic Resonance Spectroscopy; Models, Chemical; NF-kappa B; Sesquiterpenes; Sesquiterpenes, Guaiane; Spectrophotometry, Ultraviolet | 1999 |
Yeast protein farnesyltransferase. Binding of S-alkyl peptides and related analogues.
Topics: Alkyl and Aryl Transferases; Alkylation; Cysteine; Peptides; Polyisoprenyl Phosphates; Protein Binding; Saccharomyces cerevisiae; Sesquiterpenes; Spectrometry, Mass, Electrospray Ionization; Thermodynamics | 1999 |
Role of petasin in the potential anti-inflammatory activity of a plant extract of petasites hybridus.
Topics: Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Asteraceae; Calcium; Complement C5a; Cysteine; Eosinophils; Humans; Hydroxyurea; In Vitro Techniques; Leukotriene B4; Leukotrienes; Macrophages; Neutrophils; Plant Extracts; Platelet Activating Factor; Sesquiterpenes; Signal Transduction | 2001 |
Molecular cloning and characterization of peroxiredoxin from Toxoplasma gondii.
Topics: Amino Acid Sequence; Animals; Antioxidants; Artemisinins; Base Sequence; Cloning, Molecular; Cysteine; Molecular Sequence Data; Nucleic Acid Amplification Techniques; Peroxidases; Peroxiredoxins; Sesquiterpenes; Toxoplasma | 2001 |
Cysteine 38 in p65/NF-kappaB plays a crucial role in DNA binding inhibition by sesquiterpene lactones.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Cysteine; DNA-Binding Proteins; Drug Design; I-kappa B Proteins; Lactones; NF-kappa B; NF-KappaB Inhibitor alpha; Protein Binding; Protein Subunits; Quercetin; Sesquiterpenes; Transcription Factor RelA | 2001 |
The influence of glutathione and cysteine levels on the cytotoxicity of helenanolide type sesquiterpene lactones against KB cells.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Agents; Cell Survival; Cysteine; Drug Interactions; Glutathione; Humans; KB Cells; Lactones; Sesquiterpenes; Sesquiterpenes, Guaiane; Tumor Cells, Cultured | 2001 |
Differential inhibition of inflammatory effector functions by petasin, isopetasin and neopetasin in human eosinophils.
Topics: Active Transport, Cell Nucleus; Anti-Inflammatory Agents, Non-Steroidal; Blood Proteins; Calcium; Cell Nucleus; Cells, Cultured; Complement C5a; Cysteine; Cytoplasm; Enzyme Inhibitors; Eosinophil Granule Proteins; Eosinophils; Humans; Inflammation; Leukotriene Antagonists; Leukotrienes; Lipoxygenase Inhibitors; Phospholipases A; Phospholipases A2; Platelet Activating Factor; Ribonucleases; Sesquiterpenes | 2001 |
Enhanced antitumor activity of irofulven in combination with antimitotic agents.
Topics: Animals; Antibiotics, Antineoplastic; Antineoplastic Agents; Bridged-Ring Compounds; Cell Survival; Colchicine; Cysteine; Drug Synergism; Female; Lactones; Macrolides; Mice; Mice, Inbred BALB C; Neoplasm Transplantation; Sesquiterpenes; Taxoids; Tubulin; Tumor Cells, Cultured; Vinca Alkaloids | 2002 |
Schistosoma japonicum: effect of artemether on glutathione S-transferase and superoxide dismutase.
Topics: Animals; Artemether; Artemisinins; Cysteine; Dithiothreitol; Female; Glutathione Transferase; Male; Mice; Schistosoma japonicum; Schistosomiasis japonica; Schistosomicides; Sesquiterpenes; Superoxide Dismutase | 2002 |
Study on the mechanism of action of artemether against schistosomes: the identification of cysteine adducts of both carbon-centred free radicals derived from artemether.
Topics: Animals; Antimalarials; Artemether; Artemisinins; Cysteine; Free Radicals; Schistosomicides; Sesquiterpenes | 2003 |
Role of cysteine residues of p65/NF-kappaB on the inhibition by the sesquiterpene lactone parthenolide and N-ethyl maleimide, and on its transactivating potential.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Calcium-Binding Proteins; Cysteine; DNA-Binding Proteins; Ethylmaleimide; HeLa Cells; Humans; I-kappa B Kinase; Jurkat Cells; Macrophages; Membrane Glycoproteins; Mice; Mutation; Nerve Tissue Proteins; NF-kappa B; Protein Serine-Threonine Kinases; Sesquiterpenes; Synaptotagmin I; Synaptotagmins; Transcription Factor RelA; Transcriptional Activation; Transfection | 2004 |
Wound closure in the invasive green alga Caulerpa taxifolia by enzymatic activation of a protein cross-linker.
Topics: Algal Proteins; Caulerpa; Cysteine; Enzyme Activation; Esterases; Gas Chromatography-Mass Spectrometry; Molecular Structure; Sesquiterpenes; Wound Healing | 2005 |
Protein farnesyltransferase-catalyzed isoprenoid transfer to peptide depends on lipid size and shape, not hydrophobicity.
Topics: Alkyl and Aryl Transferases; Catalysis; Crystallography, X-Ray; Cysteine; Hydrophobic and Hydrophilic Interactions; Lipids; Oligopeptides; Oncogene Protein p21(ras); Polyisoprenyl Phosphates; Protein Prenylation; Sesquiterpenes; Substrate Specificity; Terpenes | 2008 |
An insect farnesyl phosphatase homologous to the N-terminal domain of soluble epoxide hydrolase.
Topics: Amino Acid Sequence; Animals; Catalysis; Cysteine; Diterpenes; Drosophila melanogaster; Enzyme Inhibitors; Epoxide Hydrolases; Molecular Sequence Data; Polyisoprenyl Phosphates; Pyrophosphatases; Sequence Homology, Amino Acid; Sesquiterpenes | 2009 |
Modulation of DNA methylation by a sesquiterpene lactone parthenolide.
Topics: Alkylation; Animals; Antineoplastic Agents; Apoptosis; Catalytic Domain; Cell Cycle; Cell Line, Tumor; Cell Survival; Chromatin Immunoprecipitation; Cysteine; Cytokines; DNA (Cytosine-5-)-Methyltransferase 1; DNA (Cytosine-5-)-Methyltransferases; DNA Methylation; Electrophoretic Mobility Shift Assay; Female; Humans; Immunoblotting; Lactones; Mice; Mice, Nude; Models, Molecular; Neoplasms; Promoter Regions, Genetic; Sesquiterpenes; Sp1 Transcription Factor; Tumor Suppressor Proteins; Xenograft Model Antitumor Assays | 2009 |
Cytotoxic effects of catechol to neuroblastoma N2a cells.
Topics: Animals; Antioxidants; Apoptosis; Ascorbic Acid; Catechols; Cell Line, Tumor; Cell Survival; Curcumin; Cysteine; Cytotoxins; Deferoxamine; Glutathione; Mice; Neuroblastoma; NF-kappa B; Reactive Oxygen Species; Sesquiterpenes; Superoxide Dismutase | 2008 |
Susceptibility of the antioxidant selenoenyzmes thioredoxin reductase and glutathione peroxidase to alkylation-mediated inhibition by anticancer acylfulvenes.
Topics: Agaricales; Alkylation; Antineoplastic Agents; Antioxidants; Cell Survival; Cysteine; Enzyme Inhibitors; Glutathione Peroxidase; HeLa Cells; Humans; Neoplasms; Polycyclic Sesquiterpenes; Selenocysteine; Sesquiterpenes; Spiro Compounds; Thioredoxin-Disulfide Reductase | 2011 |
Reconstitution of the costunolide biosynthetic pathway in yeast and Nicotiana benthamiana.
Topics: Alkyl and Aryl Transferases; Biosynthetic Pathways; Chromatography, Liquid; Cichorium intybus; Cysteine; Cytochrome P-450 Enzyme System; Glutathione; Mass Spectrometry; Molecular Sequence Data; Molecular Structure; Nicotiana; Oxidation-Reduction; Oxidoreductases; Phylogeny; Plant Proteins; Sesquiterpenes; Sesquiterpenes, Germacrane; Tanacetum parthenium; Transformation, Genetic; Yeasts | 2011 |
Disulfide scrambling in superoxide dismutase 1 reduces its cytotoxic effect in cultured cells and promotes protein aggregation.
Topics: Acetamides; Apoenzymes; Benzothiazoles; Cell Line, Tumor; Cell Survival; Cysteine; Cytotoxins; Disulfides; Enzyme Stability; Humans; Protein Multimerization; Protein Structure, Quaternary; Sesquiterpenes; Solubility; Superoxide Dismutase; Superoxide Dismutase-1; Thiazoles | 2013 |
The inhibitory effect of helenalin on telomerase activity is attributed to the alkylation of the CYS445 residue: evidence from QM/MM simulations.
Topics: Alkylation; Animals; Catalytic Domain; Computer Simulation; Cysteine; Enzyme Inhibitors; Insect Proteins; Kinetics; Models, Molecular; Protein Binding; Protein Structure, Secondary; Quantum Theory; Sesquiterpenes; Sesquiterpenes, Guaiane; Telomerase; Thermodynamics; Tribolium | 2014 |
Ainsliadimer A selectively inhibits IKKα/β by covalently binding a conserved cysteine.
Topics: Allosteric Regulation; Allosteric Site; Amino Acid Sequence; Animals; Cell Line, Tumor; Conserved Sequence; Cysteine; HEK293 Cells; HeLa Cells; Humans; I-kappa B Kinase; Lactones; Mice; Neoplasms; NF-kappa B; RAW 264.7 Cells; Sesquiterpenes; Signal Transduction | 2015 |
Covalent modification of human serum albumin by the natural sesquiterpene lactone parthenolide.
Topics: Cysteine; Humans; Plant Extracts; Serum Albumin; Sesquiterpenes; Tanacetum parthenium | 2015 |
Divergent synthesis and identification of the cellular targets of deoxyelephantopins.
Topics: Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cell Proliferation; Cysteine; Humans; Lactones; Molecular Targeted Therapy; Neoplasms; PPAR gamma; Proteomics; Recombinant Proteins; Sesquiterpenes; Zinc Fingers | 2016 |
Metabolism and pharmacokinetics of alantolactone and isoalantolactone in rats: Thiol conjugation as a potential metabolic pathway.
Topics: Animals; Chromatography, Liquid; Cysteine; Glutathione; Humans; Lactones; Male; Microsomes, Liver; Rats; Rats, Sprague-Dawley; Sesquiterpenes; Sesquiterpenes, Eudesmane; Sulfhydryl Compounds; Tandem Mass Spectrometry | 2018 |
Helenalin Analogues Targeting NF-κB p65: Thiol Reactivity and Cellular Potency Studies of Varied Electrophiles.
Topics: A549 Cells; Cysteine; Humans; Kinetics; Sesquiterpenes; Sesquiterpenes, Guaiane; Sulfhydryl Compounds; Transcription Factor RelA | 2018 |
Stimulation of the ATPase activity of Hsp90 by zerumbone modification of its cysteine residues destabilizes its clients and causes cytotoxicity.
Topics: Adenosine Triphosphatases; Bacterial Proteins; Cyanobacteria; Cysteine; Cytotoxins; Enzyme Stability; HSP90 Heat-Shock Proteins; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Sesquiterpenes | 2018 |
Melleolides from Honey Mushroom Inhibit 5-Lipoxygenase via Cys159.
Topics: A549 Cells; Arachidonate 5-Lipoxygenase; Armillaria; Cysteine; Dose-Response Relationship, Drug; Humans; Lipoxygenase Inhibitors; Molecular Structure; Sesquiterpenes; Structure-Activity Relationship | 2019 |
Beta-elemene inhibits breast cancer metastasis through blocking pyruvate kinase M2 dimerization and nuclear translocation.
Topics: Aerobiosis; Animals; Breast Neoplasms; Cell Line, Tumor; Cell Movement; Cell Nucleus; Cysteine; ErbB Receptors; Female; Fructosediphosphates; Gene Expression Regulation, Neoplastic; Glucose Transporter Type 1; Glycolysis; Humans; Mice, Inbred BALB C; Mice, Nude; Models, Biological; Neoplasm Invasiveness; Neoplasm Metastasis; Protein Multimerization; Protein Transport; Pyruvate Kinase; Sesquiterpenes; Signal Transduction | 2019 |
Unveiling fungal detoxification pathways of the cruciferous phytoalexin rapalexin A: Sequential L-cysteine conjugation, acetylation and oxidative cyclization mediated by Colletotrichum spp.
Topics: Acetylation; Brassicaceae; Colletotrichum; Cyclization; Cysteine; Isothiocyanates; Molecular Structure; Oxidative Stress; Phytoalexins; Sesquiterpenes | 2020 |
4-Octyl itaconate inhibits aerobic glycolysis by targeting GAPDH to exert anti-inflammatory effects.
Topics: Alkylation; Animals; Antimetabolites; Cysteine; Deoxyglucose; Down-Regulation; Endotoxemia; Glucose; Glyceraldehyde-3-Phosphate Dehydrogenase (Phosphorylating); Glycolysis; Inflammation; Interleukin-1beta; Lipopolysaccharides; Macrophage Activation; Macrophages; Mice; Nitric Oxide Synthase Type II; Oxidative Phosphorylation; RAW 264.7 Cells; Sesquiterpenes; Succinates | 2019 |