cysteine has been researched along with serine in 1425 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 364 (25.54) | 18.7374 |
| 1990's | 328 (23.02) | 18.2507 |
| 2000's | 465 (32.63) | 29.6817 |
| 2010's | 208 (14.60) | 24.3611 |
| 2020's | 60 (4.21) | 2.80 |
| Authors | Studies |
|---|---|
| Burnell, JN; Whatley, FR | 1 |
| Clark, PI; Lowe, G | 1 |
| Gebhart, E | 1 |
| Nakagawa, S; Umeyama, H | 1 |
| Beaton, JM; Bradley, RJ; Smythies, JR | 1 |
| Naiki, N; Takeshima, K; Yamagata, S | 2 |
| Bridgeland, ES; Gannon, F; Jones, KM | 1 |
| Fimmel, AL; Loughlin, RE | 1 |
| Umbarger, HE | 1 |
| Dingwall, C; Fersht, AR | 1 |
| Ishii, S; Ojima, S; Yokosawa, H | 1 |
| Boguslawski, G; Stetler, DA | 1 |
| Hems, R; Krebs, HA; Viña, J | 1 |
| Brocklehurst, K; Malthouse, JP | 1 |
| Cook, PF; Wedding, RT | 1 |
| Braunstein, AE; Goryachenkova, EV | 1 |
| de Jong, MH; van der Drift, C; Vogels, GD | 1 |
| Ho, CK; Kern, HL; Ostrove, SA | 1 |
| Thompson, RC | 1 |
| Ebert, C; Ebert, G; Knipp, H | 1 |
| Ananthanarayanan, VS; Raghavendra, K | 1 |
| Ahlers, J; Günther, T | 1 |
| Davis, L; Kapke, G | 1 |
| Case, GL | 1 |
| Beaton, JM | 1 |
| Foote, LJ; Hulanicka, MD; Kredich, NM | 1 |
| Cheney, RW; Kredich, NM | 1 |
| Bal, J; Morzycka, E; Pieniqzek, NJ; Steień, PP | 1 |
| Mazelis, M | 1 |
| Bayer, E; Hemmasi, B | 1 |
| Fukushima, K; Masada, M; Tamura, G | 1 |
| Patthy, L; Smith, EL | 1 |
| Braunstein, AE; Goryachenkova, EV; Maslova, RN; Tolosa, EA; Willhardt, IH | 1 |
| Auzzi, G; Bruni, F; Papini, P; Pecori Vettori, L | 1 |
| Gundalakh, AI; Mel'k, MV; Shcheglova, SA; Volkova, ZA | 1 |
| Guadalix, FJ; Ruiz, MC | 1 |
| Kester, AS; Mayfield, DC | 1 |
| Berson, EL; Hayes, KC; Schmidt, SY | 1 |
| Benassi, CA; Guggi, A; Rocchi, R; Salvadori, S; Tomatis, R | 1 |
| Heinrich, D; Kubli, F; Metz, J; Wesch, H | 1 |
| Komeiji, Y; Someya, J; Uebayasi, M; Yamato, I | 1 |
| Chen, VJ; Fox, BG; Harpel, MR; Kriauciunas, A; Lipscomb, JD; Münck, E; Orville, AM | 1 |
| Akasaka, T; Ono, N; Sawai, T; Yamaguchi, A | 1 |
| Beckert, V; Bernhardt, R; Schwarz, D; Uhlmann, H | 1 |
| Akamizu, T; Ban, T; Kohn, LD; Kosugi, S | 1 |
| Masamune, S; Palmer, MA; Peoples, OP; Sinskey, AJ; Walsh, CT; Williams, SF | 1 |
| Bailey, JE; Fenton, D; Fieschko, J; Fox, GM; Lyons, D; Rinas, U; Stearns, G; Tsai, LB | 1 |
| Boone, TC; Clogston, CL; Lu, HS; Merewether, LA; Narhi, LO; Pearl, WR | 1 |
| Grigera, PR; Keil, W; Wagner, RR | 1 |
| Douce, R; Droux, M; Martin, J; Sajus, P | 1 |
| Lee, RS; Senior, AE; Wilke-Mounts, S | 1 |
| Kato, H; Pognonec, P; Roeder, RG | 1 |
| Borhani, DW; Harter, TM; Petrash, JM | 1 |
| Lusty, CJ | 1 |
| Bouloc, P; D'Ari, R; Vinella, D | 1 |
| Asahara, H; Hasegawa, T; Himeno, H; Shimizu, M; Tamura, K | 1 |
| Naggert, J; Randhawa, ZI; Smith, S; Witkowska, HE; Witkowski, A | 1 |
| Bettler, B; Hofstetter, H; Raggini, S; Rüegg, D; Texido, G | 1 |
| Lee, GJ; McFadden, BA | 1 |
| Cavallini, D; Duprè, S; Flati, V; Maurizi, G; Pitari, G; Spera, L; Ursini, CL | 1 |
| Cheatham, B; Kahn, CR | 1 |
| Chaudière, J; Lalanne, JL; Rocher, C | 1 |
| Chen, XZ; Kopchick, JJ; Li, YS; Shafer, AW; Wagner, TE; Yun, JS | 1 |
| Glenn, JS; Havel, CM; Watson, JA; White, JM | 1 |
| Gélinas, C; Kumar, S; Rabson, AB | 1 |
| Gehring, W; Güntert, P; Müller, M; Otting, G; Qian, YQ; Wüthrich, K | 1 |
| Atkin, CL; Barker, DF; Gregory, MC; Hostikka, SL; Tryggvason, K; Zhou, J | 1 |
| DiSalvo, J; Gimenez-Gallego, G; Linemeyer, DL; Ortega, S; Schaeffer, MT; Soderman, D; Thomas, KA | 1 |
| Andersson, M; Bergenhem, N; Carlsson, U; Jonsson, BH; Kihlgren, A; Mårtensson, LG | 1 |
| Faletto, MB; Goldstein, JA; Linko, P | 1 |
| Dunbar, B; Horrocks, AJ; Lindsay, CD; Slade, A; Virden, R | 1 |
| He, JJ; Quiocho, FA | 1 |
| Alin, P; Bourke, P; Cheetham, BF; Linnane, AW; Mantamadiotis, T; McInnes, B; Murray, PJ; Tymms, MJ | 1 |
| Aronson, NN; Fisher, KJ | 1 |
| Craik, CS; Fletterick, RJ; Higaki, JN; Wilke, ME | 1 |
| Hama, H; Kayahara, T; Tsuchiya, T; Tsuda, M | 1 |
| Hryniewicz, MM; Kredich, NM | 3 |
| Amioka, H; Dojo, S; Hayashi, K; Hiraoka, M; Hirata, Y; Kurushima, H; Nakashima, K; Nishio, E; Ohtani, H; Saeki, M | 1 |
| Covitz, PA; Herskowitz, I; Mitchell, AP | 1 |
| Israel, Y; Shackel, N; Speisky, H; Varghese, G; Wade, D | 1 |
| Penttilä, KE | 1 |
| Kredich, NM; Ostrowski, J | 1 |
| Blackwell, LF; Buckley, PD; Loomes, KM; Midwinter, GG | 1 |
| Okinaga, S; Sato, M; Shibahara, S; Takeda, A; Takeuchi, T; Tomita, Y; Yamamoto, H | 1 |
| Fernandez-Checa, JC; Kaplowitz, N; Maddatu, T; Ookhtens, M | 1 |
| Drake, MR; Rao, AM; Stipanuk, MH | 1 |
| Fuchs, RL; MacIntosh, SC; Marrone, PG; McPherson, SL; Perlak, FJ | 1 |
| Kwon, BS; Overbeek, PA; Silversides, DW; Takeuchi, T; Waymire, KG; Yokoyama, T | 1 |
| Almond, N; Crawford, L; Osborn, K; Storey, A | 1 |
| Hakvoort, TB; Margoliash, E; Sprinkle, JR | 1 |
| Abram, TS; Cuthbert, NJ; Gardiner, PJ | 1 |
| Bollinger, JM; Johnston, MI; Mao, SS; Stubbe, J | 1 |
| Asano, S; Di Donato, A; Manning, JM; Martínez del Pozo, A; Masu, Y; Merola, M; Recsei, P; Tanaka, H; Tanizawa, K; Ueno, H | 1 |
| Arakawa, T; Curless, C; Fox, GM; Hsu, YR; Schiffer, SG; Tsai, LB | 1 |
| Cash, VL; Davis, R; Dean, D; Howard, JB; Moldenhauer, B | 1 |
| Fujii, J; MacLennan, DH; Maruyama, K; Tada, M | 1 |
| Alvarez, E; Davis, RJ; Gironès, N | 1 |
| Chou, WY; Matthews, KS | 1 |
| Alving, B; Iwanaga, S; Kawabata, S; Miyata, T; Saito, H; Takahashi, I | 1 |
| Beale, D; Coadwell, J | 1 |
| Augusteyn, RC; Koretz, JF; Schurtenberger, P | 1 |
| Fraser, CM | 1 |
| Bolmstedt, A; Flodby, P; Gidlund, M; Hemming, A; Lundberg, L; Olofsson, S; Wigzell, H | 1 |
| Igarashi, K; Ito, K; Iwane, M; Kurokawa, T; Sasada, R; Seno, M; Sudo, K | 1 |
| Grandgenett, DP; Horton, R; Mumm, S | 1 |
| Mego, JL | 1 |
| Evenson, JK; Sunde, RA | 1 |
| Böck, A; Leinfelder, W; Mandrand-Berthelot, MA; Zehelein, E | 1 |
| Hitaka, T; Mizutani, T | 2 |
| Aharony, D; Dobson, PT; Krell, RD | 1 |
| Goodin, DB; Mauk, AG; Smith, M | 1 |
| Bernstein, PR; Buckner, CK; Coursin, DB; Krell, RD; Laravuso, RB; Will, JA | 1 |
| Grindley, ND; Hatfull, GF | 1 |
| Aaronson, SA; Giese, NA; Robbins, KC | 1 |
| Kaback, HR; Menick, DR; Poonian, MS; Sarkar, HK; Viitanen, PV | 1 |
| Dolphin, PJ; Jauhiainen, M; Ridgway, ND | 1 |
| Kumaoka, H; Nakamura, K; Tazuya, K; Yamada, K | 1 |
| Holmes, CF | 1 |
| Bannai, S; Ishii, T; Sato, H; Watanabe, H | 1 |
| Bourre, JM; Lefauconnier, JM; Roux, F; Tayarani, I | 1 |
| Heilmeyer, LM; Hoffmann-Posorske, E; Korte, H; Meyer, HE; Swiderek, K | 1 |
| Anderson, PM; Fuchs, JA; Johnson, WV; Korte, JJ; Sung, YC; Xiong, XF | 1 |
| Erni, B; Nuoffer, C; Zanolari, B | 1 |
| Ishii, T; Nagasawa, T; Yamada, H | 1 |
| Brenner, S | 1 |
| Heilmeyer, LM; Jaquet, K; Meyer, HE; Swiderek, K | 1 |
| Harper, AE; Tews, JK; Torres, N; Tovar, A | 1 |
| Arakawa, T; Banks, AR; Fox, GM; Rohde, MF; Schiffer, SG; Tsai, LB | 1 |
| Frasier-Scott, K; Hatzakis, H; Jones, CM; Seong, D; Wu, KK | 1 |
| Blöcker, H; Frank, R; Neuhaus, JM; Overath, P; Riede, I; Soppa, J; Wright, JK | 1 |
| Kunert, J | 1 |
| Casella, A; Leoncini, R; Marinello, E; Pagani, R | 1 |
| Dupressoir, T; Lanneau, M; Loir, M; Sautière, P | 1 |
| Hunaiti, A; Janakat, S; Owais, WM | 1 |
| Dudman, NP; Tyrrell, PA; Wilcken, DE | 1 |
| Allen, JM; Andrews, RS; Warrander, A | 1 |
| Christensen, HN; Vadgama, JV | 1 |
| Kaźmierczak, A; Nowak, D; Nowak, H; Rozniecki, J | 1 |
| Kikuchi, G; Yoshida, T | 1 |
| Gerstenbrand, F; Gründig, E; Oberhummer, J; Schedl, R; Simanyi, M; Weiss, J | 1 |
| Chatagner, F; de Billy, G; Ipaktchi, M; Lefauconnier, JM; Portemer, C | 1 |
| De Lorenzo, F; Givol, D | 1 |
| Dodd, JM; Leatherland, JF | 1 |
| Jurásek, L; Smillie, LB | 1 |
| Berns, DS; Habig, W; MacColl, R | 1 |
| Hulanicka, MD; Kredich, NM; Treiman, DM | 1 |
| Cheah, KS; Watkins, JC | 1 |
| Schmid, A | 2 |
| Fedorchenko, EIa; Petrun', LM | 1 |
| Plapp, R; Strominger, JL | 1 |
| Beumer-Jochmans, MP; Godard, C | 1 |
| Yoshida, A | 1 |
| Byrne, WL; Fallon, HJ; Hackney, EJ | 1 |
| Donnell, GN; Koch, R; Lieberman, E; Shaw, KN | 1 |
| Lohmann, W; Momeni, M; Nette, P | 1 |
| Davis, JL; Fallon, HJ; Goyer, RA | 1 |
| Fallon, HJ | 1 |
| Abrol, YP; Blumenthal, SG; Conn, EE; Hendrickson, HR | 1 |
| Allen, RE; Raines, PL; Regen, DM | 1 |
| Gregory, EM; Harrison, JH; Rohrbach, MS | 1 |
| Karadźić, V; Micić, D; Rakić, L | 1 |
| Cagen, LM; Friedmann, HC | 1 |
| Crippa, PR; Tedeschi, RA; Vecli, A | 1 |
| Braun, PE; Snell, EE | 1 |
| Miyajima, R; Otsuka, S; Shiio, I | 1 |
| Bryan, JK | 1 |
| Josephs, JA; Magazino, J; Parker, CM; Sprince, H | 1 |
| Read, CP; Southworth, GC | 1 |
| Kornecki-Gerrity, EH; Penney, DG | 1 |
| Beaton, JM; Bradley, RJ; Pegram, GV; Smythies, JR | 1 |
| Lifshitz, F; Wapnir, RA | 1 |
| Andrews, AT | 1 |
| Attardi, G; Costantino, P | 1 |
| Kubacz, GJ | 1 |
| Lipsett, MN | 1 |
| Konisky, J | 1 |
| York, SS | 1 |
| Hulanicka, D; Klopotowski, T; Smith, DA | 1 |
| Biserte, G; Dautrevaux, M; Han, K | 1 |
| Hatfield, D | 1 |
| Marshall, RD | 1 |
| Paszewski, A; Pieniazek, N; Stepień, PP | 1 |
| Clarke, SJ; Kalousek, F; Konigsberg, WH; Waterson, RM | 1 |
| Collins, JM; Monty, KJ | 1 |
| Lawrence, F | 1 |
| Bhattacharya, RK | 1 |
| Granroth, B; Sarnesto, A | 1 |
| Sanders, BG; Travis, JC | 1 |
| Van Campen, D | 1 |
| DeMoss, RD; Hoch, SO | 1 |
| Shargool, PD | 1 |
| Pieniazek, NJ; Stepién, PP | 1 |
| Hill, LJ; Martin, WG | 1 |
| Paul, RC; Ratledge, C | 1 |
| Ayres, M; Rucknagel, DL; Salzano, FM; Seid-Akhavan, M; Winter, WP | 1 |
| Schmidt, A | 1 |
| Bossa, F; Cavallini, D; Federici, G; Granata, F | 1 |
| Cooper, AJ; Meister, A | 1 |
| Fridkin, M; Goren, HJ | 1 |
| Amiconi, G; Antonini, E; Bonaventura, C; Bonaventura, J; Brunori, M; Tondo, C | 1 |
| Aguilar, TS; Benevenga, NJ; Harper, AE | 1 |
| Ngo, TT; Shargool, PD | 1 |
| Boguslawski, J; Klopotowski, T; Walczak, W | 1 |
| Baldwin, RL; Goldberg, ME | 1 |
| Datta, P | 1 |
| Crawford, IP; Hatanaka, M; Ito, J | 1 |
| Becker, MA; Kredich, NM; Tomkins, GM | 2 |
| Harada, T; Murooka, Y; Seto, K | 1 |
| Butler, JA; Johns, EW; Phillips, DM | 1 |
| Gregory, H | 1 |
| Kumagai, H; Matsui, H; Ogata, K; Ohkishi, H; Yamada, H | 1 |
| Carr, HS; Rosenkranz, HS; Zyroff, J | 1 |
| Degani, Y; Patchornik, A; Spande, TF; Witkop, B | 1 |
| Bender, ML; Polgár, L | 4 |
| Jörnvall, H | 2 |
| Coulter, AW; Lombardini, JB; Talalay, P | 1 |
| Kishida, Y; Sakakibara, S | 1 |
| Kredich, NM | 1 |
| Staehelin, M; Wehrli, W | 1 |
| Beaudet, A; Caskey, CT; Nirenberg, M | 1 |
| DeLange, RJ; Smith, EL | 1 |
| Nurmikko, V; Pyykkö, K | 1 |
| Hampton, JR | 1 |
| Hardman, DF; Hardman, JK | 1 |
| Kumagai, H; Miles, EW | 1 |
| Smith, DA | 1 |
| Conn, EE; Floss, HG; Hadwiger, L | 1 |
| Koshland, DE; Nanci, A; Neet, KE | 1 |
| Jesensky, C; Peterkofsky, A | 1 |
| Becker, MA; Tomkins, GM | 1 |
| Etzler, ME; Kabat, EA | 1 |
| Alföldi, L; Kerekes, E; Raskó, I | 1 |
| Buu-Hoï, NP; Hauspie, R; Lambelin, G; Nicolle, J | 1 |
| Coan, MH; Roberts, RC; Travis, J | 1 |
| Chambers, LA; Trudinger, PA | 1 |
| Horowitz, MI; Kim, YS | 1 |
| Castric, PA; Conn, EE | 1 |
| Merkel, JR; Sipos, T | 1 |
| Marzluff, WF; McCarty, KS | 1 |
| Husain, I; Norris, RF; Poupard, JA | 1 |
| Powers, JC; Robillard, GT; Wilcox, PE | 1 |
| Nath, M; Sanwal, GG | 1 |
| Asmar, JA; Daghir, NJ; Sifri, M | 1 |
| Flavin, M; Posner, BI | 1 |
| Davies, JV; Ebert, M; Musch, K; Siebert, G | 1 |
| Ponnuswamy, PK; Sasisekharan, V | 2 |
| Braunstein, AE; Goryachenkova, EV; Tolosa, EA; Willhardt, IH; Yefremova, LL | 1 |
| Hoshino, J; Kröger, H; Simon, D | 1 |
| Christensen, HN; Koser, BH | 1 |
| Hornig, D; Weber, F; Wiss, O | 1 |
| Markelova, SI; Zharikova, GG | 3 |
| Kearney, EB; Seng, R; Singer, TP; Walker, WH | 1 |
| Furka, A | 1 |
| Carminatti, H; Jiménez de Asúa, L; Leiderman, B; Rozengurt, E | 1 |
| Koshland, DE; Neet, KE | 1 |
| Kabat, EA | 1 |
| Gibbons, RJ; Loesche, WJ | 1 |
| Guest, JR; Yanofsky, C | 1 |
| Dunnill, PM; Fowden, L | 1 |
| Kredich, NM; Tomkins, GM | 1 |
| Morino, Y; Snell, EE | 1 |
| Giovanelli, J; Mudd, SH | 4 |
| Flavin, M; Slaughter, C | 2 |
| Hock, A; Rüstow, B | 1 |
| Diven, WF; Johnston, MM | 1 |
| Hoshino, S; Tsubota, H | 1 |
| Cooper, IA; Firkin, BG | 1 |
| Joshi, VC; Plate, CA; Wakil, SJ | 1 |
| Fothergill, JE; Fothergill, LA | 1 |
| Blackburn, MN; Chatterjee, GC; Noltmann, EA; Pon, NG; Schnackerz, KD | 1 |
| Hodgson, E; Kumar, SS | 1 |
| Brown, MS; Edwards, WA; Laster, L; Loeb, PM; Mudd, SH | 1 |
| Haber, E; Waterfield, M | 1 |
| Neuhoff, V; Weise, M | 1 |
| Briedis, I; Goncharenko, EN; Kudriashov, IuB | 1 |
| Chen, DM; McConnell, WB; Nigam, SN | 1 |
| Kanfer, JN | 1 |
| Gerstenbrand, F; Gründig, E | 1 |
| Melcher, G | 1 |
| Baranova, IP; Egorov, NS | 1 |
| Artiukh, VP; Shtutman, TsM | 1 |
| Garg, GK; Virupaksha, TK | 1 |
| Smith, IK; Thompson, JF | 1 |
| McConnell, WB; Nigam, SN | 1 |
| Fersht, AR | 1 |
| Hexter, CS; Westheimer, FH | 1 |
| Diller, A; Schirch, LV | 1 |
| Kimura, T; Nagata, Y; Tsurugi, J | 1 |
| Spence, KD | 1 |
| Brown, FC; Gordon, PH | 2 |
| Kloss, G; Schwarz, E | 1 |
| Hörnle, S | 1 |
| Ansorge, S; Bohley, P | 1 |
| Demeyer, DI; Henderickx, HK | 1 |
| De Issaly, IS | 1 |
| Flavin, M; Guggenheim, S | 1 |
| Heitmann, P | 1 |
| Moore, DP; Thompson, JF | 1 |
| Brown, JH; Mackey, HK | 1 |
| Komrower, GM; Schwarz, V; Wong, PW | 1 |
| Manahan, J; Mandl, I | 1 |
| Steenbergen, ST; Weinberg, ED | 1 |
| Fasman, GD; Potter, J; Stevens, L; Timasheff, SN; Townend, R | 1 |
| Meun, DH; Smith, KC | 1 |
| Schneider, G | 1 |
| Huovinen, JA | 2 |
| Conn, EE; Hendrickson, HR | 1 |
| Braunstein, AE; Goryachenkova, EV; Lac, ND | 1 |
| Schoonhoven, LM | 1 |
| Ingram, LC | 1 |
| McCormick, DB; Sigel, H; Wright, LD | 1 |
| Anwar, RA; Narayanan, AS | 1 |
| Beyer, H; Schenk, U | 1 |
| Daniels, VG; Newey, H; Smyth, DH | 1 |
| Konikova, AS; Kritzman, MG; Morenkova, SA | 1 |
| Dimant, E; Hochberg, A | 1 |
| Connell, GE; Szewczuk, A | 1 |
| Bardakos, V; Photaki, I | 2 |
| Byrne, WL; Fallon, HJ | 1 |
| Palestro, G; Terracini, B | 1 |
| Martin, WG; Miraglia, RJ; Patrick, H; Spaeth, DG | 1 |
| Christian, JH; Waltho, JA | 1 |
| Ebata, M; Otsuka, H; Takahashi, Y | 1 |
| Elinov, NP; Kashkin, AP | 1 |
| Belugina, OP; Paducheva, AL | 1 |
| Fasman, GD; Potter, J | 1 |
| Meister, A; Miles, EW | 1 |
| Harper, E; Scharrer, B; Seifter, S | 1 |
| Efron, ML; Mechanic, GL; Shih, VE | 1 |
| Carlisle, SA; Morse, GE; Willett, NP | 1 |
| Agnihotri, VP; Vaartaja, O | 1 |
| Archer, EG; Christensen, HN; Liang, M | 1 |
| Schwartz, IL; Theodoropoulos, D; Walter, R | 1 |
| Krell, RD; Snyder, DW | 1 |
| Lal, DN; Srivastava, AS | 1 |
| Aharony, D; Dobson, P; Krell, RD; Snyder, DW; Tsai, BS | 1 |
| Austen, KF; Corey, EJ; Krilis, S; Lewis, RA | 1 |
| Sherman, AD; Waziri, R; Wilson, R | 1 |
| Kramer, MF; Smits, HL | 1 |
| DeGrado, WF; Petteway, SR; Sigal, IS; Thomas, BJ | 1 |
| Gray, TM; Matthews, BW | 1 |
| Lu, SD; Mark, DF; Wang, A | 1 |
| Lenney, JF | 1 |
| László, P; Mihály, S | 1 |
| Ellory, JC; Jones, SE; Young, JD | 1 |
| Camakaris, J; Danks, DM; Lazdins, I; Mercer, JF; Stevenson, T | 1 |
| Dunlap, RB; Munroe, WA | 1 |
| Dall'Asta, V; Franchi-Gazzola, R; Gazzola, GC; Guidotti, GG | 1 |
| Fersht, AR; Smith, M; Wilkinson, AJ; Winter, G; Zoller, M | 1 |
| White, RH | 1 |
| Arentzen, R; Harwood, BG; Sigal, IS | 1 |
| Barrett, AJ | 1 |
| Honig, GR; Mason, RG; Shahidi, NT; Shamsuddin, M; Tarr, GE; Tremaine, LM; Vida, LN | 1 |
| Jahoor, F; Jaksic, T; Miller, RG | 1 |
| Farrés, J; Rout, UJ; Wang, X; Weiner, H; Zheng, CF | 1 |
| Azzariti, A; Doonan, S; Giannattasio, S; Marra, E; Merafina, RS; Quagliariello, E | 1 |
| Rosevear, PR; Zhou, L | 1 |
| Li, J; Pickart, CM | 1 |
| Arakawa, T; Boone, TC; Kenney, WC; Narhi, LO; Prestrelski, SJ | 1 |
| Eckardt, S; Köhr, G; Lüddens, H; Monyer, H; Seeburg, PH | 1 |
| Holsinger, LJ; Lamb, RA; Micko, A; Pinto, LH; Shaughnessy, MA | 1 |
| Hopkins, N; Williams, CH | 2 |
| Cecchini, G; Gunsalus, RP; Johnson, MK; Kowal, AT; Manodori, A; Schröder, I; Werth, MT | 1 |
| Dean, M; Goldman, D; Lappalainen, J; Linnoila, M; Oz, M; Ozaki, N; Virkkunen, M; Weight, F; Yu, DH; Zhang, L | 1 |
| Grassie, MA; Guzzi, F; Magee, AI; McCallum, JF; Milligan, G; Parenti, M; Wise, A | 1 |
| Dowd, SR; Ho, C; Pratt, EA; Sun, ZY | 1 |
| Banerjee, A; Chau, V; Deshaies, RJ | 1 |
| Gerchman, Y; Olami, Y; Padan, E; Rimon, A; Schuldiner, S | 1 |
| Bates, DM; Kiley, PJ; Lazazzera, BA | 1 |
| Murakoshi, I; Noji, M; Saito, K; Yokoyama, H | 1 |
| Bhagwat, AS; Gabbara, S; Sheluho, D | 1 |
| Barry, PH; Cunningham, AM; French, PW; Pierce, KD; Rajendra, S; Schofield, PR; Vandenberg, RJ | 1 |
| Gaillard, J; Lutz, M; Meyer, J | 1 |
| Schmidt, G; Senior, AE | 1 |
| Heilmeyer, LM; Jaquet, K; Thieleczek, R | 1 |
| Antón, DN; Oppezzo, OJ | 1 |
| Bonander, N; Karlsson, BG; Vänngård, T | 1 |
| Davies, PJ; el Alaoui, S; Gentile, V; Griffin, M; Lawry, J; Mian, S | 1 |
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| Chesnov, S; Freisinger, E; Habjanič, J; Zerbe, O | 1 |
| Chen, W; Cui, Z; Li, W; Liu, S; Wei, R; Wu, X; Xie, L; Xu, S; Zhou, Y | 1 |
| Chang, MS; Choi, D; Jang, J; Jung, D; Kang, S; Kim, D; Kim, Y; Lee, Y; Nam, SH; Park, JU; Sim, C | 1 |
| Bredvik, K; Calder, EL; Chen, Q; Cheng, RR; Fischer, SM; Gross, SS; Kawamata, H; Konrad, C; Manfredi, G; Roychoudhury, D; Sandhu, D; Schwartz, BI; Studer, L | 1 |
| Astegno, A; Conter, C; Dominici, P; Fernández-Rodríguez, C; Fruncillo, S; Martínez-Cruz, LA | 1 |
| Brenner, V; Donon, J; Gloaguen, E; Goldsztejn, G; Mons, M; Mundlapati, VR; Tardivel, B | 1 |
| Stipanuk, MH | 1 |
| Fernández-García, C; Foden, CS; Islam, S; Maugeri, L; Powner, MW; Sheppard, TD | 1 |
| Abidi, A; Beriou, G; Dilek, N; Gueno, L; Lancien, M; Louvet, C; Merieau, E; Michielin, O; Nguyen, TH; Poschmann, J; Salle, S; Solomon, P; Vanhove, B; Vuillefroy de Silly, R | 1 |
| Badepally, NG; Singh, A; Surolia, A | 1 |
| Han, F; Huang, Z; Liu, Y; Wang, Q; Wu, H; Zhan, S | 1 |
| Bai, Y; Hu, M; Huang, H; Peng, J; Wang, J; Xie, A | 1 |
| Hicks, JL; Oldham, KEA; Prentice, EJ; Summers, EL | 1 |
| Elreedy, A; Fujii, M; Hedenström, M; Isaksson, S; Liu, T; Schnürer, A; Shakeri Yekta, S | 1 |
| Fu, C; He, L; Huang, S; Huang, Y; Li, J; Liu, L; Niu, H; Peng, T; Tang, H; Wang, W; Xu, K; Xu, Y; Yang, X; Zhao, Y; Zhou, H | 1 |
| Antipova, VN; Artyukh, RI; Fatkhullin, BF; Kachalova, GS; Perevyazova, TA; Yunusova, AK | 1 |
| Bekturova, A; Dubey, AK; Kurmanbayeva, A; Nurbekova, Z; Oshanova, D; Sagi, M; Soltabayeva, A; Srivastava, S; Tiwari, P | 1 |
| Andersen, KR; Hansen, SB | 1 |
| Cravatt, BF; Dix, MM; Kemper, EK; Zhang, Y | 1 |
| Chen, H; Pan, H; Ren, F; Ren, P; Wang, W | 1 |
| Al Mamun, AAM; Chang, C; Das, A; Sanchez, BC; Ton-That, H; Wu, C | 1 |
| Patra, AK; Yu, Z | 1 |
| Bastani, N; Elshorbagy, AK; Kwok, T; Refsum, H; Turner, C | 1 |
| Bombarda, E; Gisdon, FJ; Ullmann, GM | 1 |
| Li, X; Liu, J | 1 |
| Prompat, N; Roongsawang, N; Saetang, J; Sangkaew, N; Sangkhathat, S; Srichana, T; Tipmanee, V; Voravuthikunchai, SP | 1 |
| Dharavath, S; Gourinath, S; Kumar, S; Kumari, K | 1 |
| Hutchin, A; Kopec, J; Majtan, T; Petrosino, M; Szabo, C; Zuhra, K | 1 |
| Guiley, KZ; Shokat, KM; Zhang, Z | 1 |
| Hara, KY; Hasunuma, T; Kobayashi, J; Kondo, A; Sasaki, D | 1 |
| Bochtler, M; Czapinska, H | 1 |
| Burrows, CJ; Chen, HN; Fleming, AM; Howpay Manage, SA | 1 |
| Chen, X; Ge, T; He, Z; Wang, J; Yuan, H; Zhang, L | 1 |
| Hancock, JT; Hu, X; Hu, Y; Huang, J; Li, P; Lu, S; Yang, W; Ying, S; Zhou, Y | 1 |
| Blanco, M; Jiménez-Osés, G; Mazo, N; Navo, CD; Oroz, P; Peregrina, JM | 1 |
| Homma, H; Katane, M; Miyamoto, T; Saitoh, Y; Sakai-Kato, K; Sekine, M | 1 |
| Fogg, PCM; Sherlock, D | 1 |
| Addo, KA; Huang, YY; Huang, ZX; Li, H; Xiao, XL; Yu, YG | 1 |
| Aldrovandi, GM; Clark, JL; D'Aquila, R; Elliott, J; Fulcher, JA; Gorbach, PM; Kipke, MD; Li, F; Mustanski, B; Shoptaw, S; Tobin, NH; Zabih, S | 1 |
| Funabashi, H; Hirota, R; Ikeda, T; Ishida, T; Katsuura, ZI; Kuroda, A; Momokawa, N; Murakami, H; Watanabe, S | 1 |
| Ji, G; Luo, B; Shen, G; Tian, T | 1 |
| Baysal, İ; Chankvetadze, B; Gumustas, M; Kale, NB; Kır, S; Nemutlu, E; Öztepe, T; Reçber, T; Yabanoğlu-Çiftçi, S | 1 |
| Guo, ZJ; Liu, Y; Zhou, XW | 1 |
| Cui, Y; Feng, C; Gao, H; Li, D; Mao, H; Wang, C; Wei, X; Yang, J; Zhu, J | 1 |
| Ables, GP; Bastani, NE; Cooke, D; Kožich, V; Malloy, VL; Mansilla, W; Mattocks, DAL; Midya, V; Nichenametla, SN; Olsen, T; Pavlíková, M; Refsum, H; Richie, JP; Shoveller, AK; Sokolová, J; Turner, C; Vinknes, KJ; Øvrebø, B | 1 |
| Castro-Vazquez, A; Colgrave, ML; Escobar-Correas, S; Mendoza-Porras, O; Vega, IA | 1 |
| Endo, K; Kitamura, H; Makabe, H; Sawa, T; Tanaka, S; Umezawa, K | 1 |
| Fu, ZZ; Huang, QL; Jiang, RY; Wu, DP; Wu, XJ; Yan, S; Yang, BY; Yang, LL; Zhao, RR | 1 |
| Fulem, M; Havlín, J; Pokorný, V; Růžička, K; Štejfa, V | 1 |
| Eckhard, U; Gomis-Rüth, FX; Guevara, T; Mendes, SR; Moliner-Culubret, M; Rodríguez-Banqueri, A | 1 |
| Ackerman, HD; Caldwell, S; Combs, JA; DeNicola, GM; Falzone, A; Flores, ER; Prieto-Farigua, N; Yoon, SJ | 1 |
| Roychaudhuri, R | 1 |
| Chang, YJ; Chi, PY; García Fernández, JM; González-Cuesta, M; Hsu, IL; Lai, AC; Liu, NT; Ortiz Mellet, C; Wu, KC | 1 |
| Che, L; Fang, Z; Feng, B; Hua, L; Jiang, X; Li, J; Lin, Y; Sun, M; Wang, Y; Xu, S; Zhuo, Y; Zou, X | 1 |
| Chen, M; Chen, ZS; Deng, R; Huang, J; Huang, M; Liu, R; Lyu, W; Miao, Q; Qi, M; Qi, Q; Wang, C; Wen, Q; Wu, C; Xie, J; Ye, W; Zhang, D; Zhang, J; Zhang, Z | 1 |
| He, C; Lin, S; Mo, Z; Wang, P | 1 |
| Dong, W; Liu, H; Qi, F; Sun, Z; Wang, J; Wang, M; Wu, X; Wu, Y; Zhang, X; Zhao, M; Zhao, R; Zheng, Z | 1 |
| Chen, J; Cui, X; Fang, N; Wu, Y; Xiao, D; Yu, S | 1 |
| Akamatsu, M; Asao, M; Fujita, T; Iwamura, H | 1 |
| Cha, SH; Chairoungdua, A; Endou, H; Kanai, Y; Kim, DK; Matsuo, H | 1 |
| Dean, KE; Klein, G; Renaudet, O; Reymond, JL | 1 |
| Brandsch, M; Gebauer, S; Laug, L; Schäfer, S; Thondorf, I; Voigt, V; Zebisch, K | 1 |
| Arora, S; Chaturvedi, A; Heuser, M; Joshi, G; Kumar, R; Patil, S | 1 |
45 review(s) available for cysteine and serine
| Article | Year |
|---|---|
Amino acid biosynthesis and its regulation.
Topics: Amino Acids; Arginine; Aspartic Acid; Cysteine; Glutamates; Glutamine; Histidine; Phenylalanine; Pyruvates; Serine; Tyrosine | 1978 |
The pyridoxal-phosphate-dependent enzymes exclusively catalyzing reactions of beta-replacement.
Topics: Amino Acids; Animals; Carboxy-Lyases; Chick Embryo; Chloromercuribenzoates; Cystathionine beta-Synthase; Cystathionine gamma-Lyase; Cysteine; Cystine; Kinetics; Lyases; Nitriles; Pyridoxal Phosphate; Rats; Serine; Sulfhydryl Compounds; Thiocyanates | 1976 |
Methylation & schizophrenia.
Topics: Amines; Amino Acids; Animals; Behavior, Animal; Catecholamines; Cats; Cystathionine; Cysteine; Dihydroxyphenylalanine; Drug Tolerance; Hallucinogens; Homocysteine; Humans; Indoles; Methionine; Methylation; Mice; Schizophrenia; Serine; Taurine | 1975 |
Incorporation of selenium into glutathione peroxidase.
Topics: Animals; Cysteine; Glutathione Peroxidase; Rats; Selenium; Serine | 1987 |
[Chemical modifications of proteins: application to the study of their covalent structure (continuation and end)].
Topics: Aspartic Acid; Carbon Isotopes; Cysteine; Cystine; Electrophoresis, Paper; Lysine; Methionine; Methods; Peptides; Protein Conformation; Protein Hydrolysates; Proteins; Serine | 1972 |
Glycoproteins.
Topics: Amino Acid Sequence; Asparagine; Carbohydrates; Cysteine; Glucosamine; Glycoproteins; Hydroxylysine; Models, Structural; Mucins; Polyribosomes; Protein Conformation; Serine; Threonine | 1972 |
Recent investigations on histones and their functions.
Topics: Amino Acids; Animals; Arginine; Cattle; Cysteine; DNA; Electrophoresis, Disc; Gels; Histones; Lysine; Methods; Nucleoproteins; Peptide Hydrolases; Peptides; Plants; Rats; RNA; Serine; Thymus Gland; Trypsin | 1968 |
Some polypeptides influencing gastric-acid secretion.
Topics: Amides; Animals; Aspartic Acid; Cattle; Chemical Phenomena; Chemistry; Cysteine; Dogs; Female; Gastric Juice; Gastrins; Gastrointestinal Hormones; Humans; Methionine; Peptides; Phenylalanine; Pregnancy; Propionates; Serine; Sheep; Swine; Tryptophan | 1970 |
Selective cleavage and modification of peptides and proteins.
Topics: Alanine; Aspartic Acid; Chemical Phenomena; Chemistry; Chymotrypsin; Cysteine; Glutamates; Glycine; Hydrogen-Ion Concentration; Methionine; Muramidase; Oxidation-Reduction; Peptides; Phenylalanine; Proline; Proteins; Pyrrolidines; Ribonucleases; Serine; Succinates; Threonine; Tryptophan | 1970 |
Simulated mutation at the active site of biologically active proteins.
Topics: Acetates; Amino Acids; Binding Sites; Chemical Phenomena; Chemistry; Chromatography, Ion Exchange; Cinnamates; Cysteine; Endopeptidases; Kinetics; Models, Chemical; Mutation; Proteins; Serine; Sulfhydryl Compounds; Sulfonic Acids | 1970 |
[Synthesis of peptides by solid phase method. 1].
Topics: Arginine; Asparagine; Cysteine; Esters; Glutamine; Histidine; Lysine; Methionine; Methods; Peptides; Polystyrenes; Serine; Threonine | 1971 |
Histones: structure and function.
Topics: Acetates; Acylation; Amino Acid Sequence; Animals; Arginine; Cattle; Chemical Phenomena; Chemistry; Chromatin; Cysteine; Cystine; DNA; Female; Histidine; Histones; Lysine; Male; Methylation; Molecular Weight; Oxidation-Reduction; Phosphoproteins; Phosphoric Acids; Protein Binding; Protein Conformation; RNA; Serine; Thymus Gland | 1971 |
S-amino acid metabolism and its regulation in Escherichia coli and Salmonella typhimurium.
Topics: Amino Acids; Aspartic Acid; Chromosome Mapping; Chromosomes, Bacterial; Conjugation, Genetic; Cysteine; Escherichia coli; Feedback; Genes; Genes, Regulator; Homocysteine; Methionine; Methylation; Salmonella; Salmonella typhimurium; Serine; Sulfates; Transduction, Genetic | 1971 |
Inhibitors associated with the proteinases of mammalian cells and tissues.
Topics: Animals; Aspartic Acid; Binding Sites; Cell Compartmentation; Cysteine; Hot Temperature; Humans; Kinetics; Lysosomes; Metals; Protease Inhibitors; Serine | 1980 |
The many forms and functions of cellular proteinases.
Topics: Animals; Binding Sites; Carboxylic Acids; Cathepsins; Cysteine; Endopeptidases; Enzyme Activation; Humans; Metalloproteins; Peptide Hydrolases; Protease Inhibitors; Serine; Terminology as Topic | 1980 |
Site directed mutagenesis to probe for active site components of liver mitochondrial aldehyde dehydrogenase.
Topics: Aldehyde Dehydrogenase; Animals; Binding Sites; Catalysis; Cysteine; Electron Transport; Mitochondria, Liver; Mutagenesis, Site-Directed; Serine | 1995 |
Lysosomal glycosylasparaginase: a member of a family of amidases that employ a processed N-terminal threonine, serine or cysteine as a combined base-nucleophile catalyst.
Topics: Amidohydrolases; Amino Acid Sequence; Aspartylglucosylaminase; Cysteine; Hydrolysis; Lysosomes; Molecular Sequence Data; Protein Processing, Post-Translational; Sequence Homology, Amino Acid; Serine; Threonine | 1996 |
Computational analysis of bacterial sulfatases and their modifying enzymes.
Topics: Amino Acid Sequence; Bacteria; Binding Sites; Computational Biology; Cysteine; Humans; Molecular Sequence Data; Serine; Sulfatases | 1998 |
[Effects of the combined deficiency of selenium and iodine on thyroid function].
Topics: Cysteine; Humans; Iodine; Selenium; Serine; Thyroid Gland; Thyrotropin | 1998 |
Regulation of sulfate transport and synthesis of sulfur-containing amino acids.
Topics: Biological Transport; Carrier Proteins; Cysteine; Gene Expression Regulation, Plant; Membrane Transport Proteins; Methionine; Models, Biological; Serine; Signal Transduction; Sulfate Transporters; Sulfates | 2000 |
[Sulfur-containing amino acid metabolism in parasitic protozoa].
Topics: Acetyltransferases; Amino Acids, Sulfur; Animals; Carbon-Sulfur Lyases; Cysteine; Cysteine Synthase; Drug Design; Eukaryota; Hydrogen Sulfide; Serine; Serine O-Acetyltransferase | 2002 |
Steps towards an integrated view of nitrogen metabolism.
Topics: Amino Acid Oxidoreductases; Amino Acids; Asparagine; Cysteine; Gene Expression Regulation, Plant; Glutamate Dehydrogenase; Glutamine; Glycine; Ketoglutaric Acids; Malates; Nicotiana; Nitrate Reductase; Nitrate Reductases; Nitrates; Nitrogen; Oxidation-Reduction; Quaternary Ammonium Compounds; Serine; Signal Transduction | 2002 |
Mechanistic studies on protein tyrosine phosphatases.
Topics: Amino Acid Sequence; Animals; Bacterial Proteins; Binding Sites; cdc25 Phosphatases; Cysteine; Hydrolysis; Kinetics; Models, Biological; Models, Chemical; Molecular Sequence Data; Protein Structure, Secondary; Protein Structure, Tertiary; Protein Tyrosine Phosphatases; Sequence Homology, Amino Acid; Serine; Signal Transduction; Species Specificity | 2003 |
Numerous posttranslational modifications provide opportunities for the intricate regulation of metabolic enzymes at multiple levels.
Topics: Arabidopsis; Cysteine; Glycosylation; Oxidation-Reduction; Phosphorylation; Plant Proteins; Plants; Protein Processing, Post-Translational; Proteomics; Serine; Thioredoxins; Threonine | 2004 |
[Outcome of genetic studies on atypical psychoses].
Topics: Chromosomes, Human, Pair 1; Cysteine; Genetic Predisposition to Disease; Haplotypes; Humans; Membrane Proteins; Microsatellite Repeats; Molecular Diagnostic Techniques; Mutation; Polymorphism, Genetic; Presenilin-1; Psychotic Disorders; Receptor, Serotonin, 5-HT2A; Receptors, Dopamine D2; Serine; Taq Polymerase | 2004 |
Post-translational modifications during lantibiotic biosynthesis.
Topics: Amino Acid Sequence; Anti-Bacterial Agents; Bacteriocins; Cell Wall; Cysteine; Lanatosides; Lipid Metabolism; Molecular Sequence Data; Peptides; Protein Processing, Post-Translational; Serine; Substrate Specificity; Threonine | 2004 |
The serine acetyltransferase reaction: acetyl transfer from an acylpantothenyl donor to an alcohol.
Topics: Acetyl Coenzyme A; Acetylation; Acetyltransferases; Alcohols; Binding Sites; Catalysis; Cysteine; Enzyme Stability; Feedback, Physiological; Histidine; Hydrogen-Ion Concentration; Kinetics; Models, Molecular; Models, Structural; Molecular Structure; Molecular Weight; Protein Binding; Protein Conformation; Protein Structure, Quaternary; Protein Structure, Secondary; Serine; Serine O-Acetyltransferase; Substrate Specificity | 2005 |
Isosteric replacement of sulfur with other chalcogens in peptides and proteins.
Topics: Chalcogens; Crystallography, X-Ray; Cysteine; Methionine; Models, Molecular; Peptides; Proteins; Selenium; Serine; Sulfur; Tellurium | 2005 |
Sulfur-containing amino acid metabolism in parasitic protozoa.
Topics: Amino Acids, Sulfur; Animals; Cysteine; Drug Design; Entamoeba histolytica; Eukaryota; Eukaryotic Cells; Gene Expression Regulation, Developmental; Humans; Lyases; Mammals; Methionine; Protozoan Infections; Serine; Sulfur; Trichomonas vaginalis; Trypanosoma cruzi | 2005 |
Functional analysis of the cysteine synthase protein complex from plants: structural, biochemical and regulatory properties.
Topics: Arabidopsis; Cysteine; Cysteine Synthase; Genome, Plant; Plants; Protein Subunits; Serine; Serine O-Acetyltransferase; Sulfates; Sulfides | 2006 |
Human prostacyclin receptor structure and function from naturally-occurring and synthetic mutations.
Topics: Amino Acid Sequence; Asparagine; Binding Sites; Cysteine; Models, Molecular; Molecular Sequence Data; Mutation; Nuclear Magnetic Resonance, Biomolecular; Palmitic Acid; Polymorphism, Genetic; Polymorphism, Single Nucleotide; Proline; Protein Structure, Secondary; Protein Structure, Tertiary; Receptors, Epoprostenol; Serine | 2007 |
Genetic association study and meta-analysis of the HTR2C Cys23Ser polymorphism and migraine.
Topics: Adult; Amino Acid Substitution; Brain; Case-Control Studies; Chromosomes, Human, X; Cysteine; DNA Mutational Analysis; Female; Gene Frequency; Genetic Markers; Genetic Predisposition to Disease; Genetic Testing; Humans; Male; Middle Aged; Migraine Disorders; Point Mutation; Polymorphism, Genetic; Receptor, Serotonin, 5-HT2C; Risk Factors; Serine; Serotonin | 2007 |
Recent advances in understanding plant response to sulfur-deficiency stress.
Topics: Arabidopsis; Cysteine; Genes, Plant; MicroRNAs; Models, Biological; Plant Development; Plants; RNA, Plant; Serine; Stress, Physiological; Sulfhydryl Compounds; Sulfur; Systems Biology | 2008 |
Advanced research on dopamine signaling to develop drugs for the treatment of mental disorders: Ser311Cys polymorphisms of the dopamine D2-receptor gene and schizophrenia.
Topics: Alleles; Animals; Cysteine; Dopamine; Drug Discovery; Humans; Mental Disorders; Polymorphism, Genetic; Receptors, Dopamine D2; Schizophrenia; Serine; Signal Transduction | 2010 |
RET codon 609 mutations: a contribution for better clinical managing.
Topics: Carcinoma, Medullary; Carcinoma, Neuroendocrine; Codon; Cysteine; Genetic Association Studies; Germ-Line Mutation; Humans; Hyperparathyroidism; Italy; Multiple Endocrine Neoplasia Type 2a; Pedigree; Proto-Oncogene Mas; Proto-Oncogene Proteins c-ret; Serine; Thyroid Neoplasms | 2012 |
Prospects in the total synthesis of protein therapeutics.
Topics: Cysteine; Erythropoietin; Humans; Interferon-beta; Parathyroid Hormone; Peptides; Proteins; Serine | 2013 |
A meta-analysis of the association between the hOGG1 Ser326Cys polymorphism and the risk of esophageal squamous cell carcinoma.
Topics: Aged; Alleles; Carcinoma, Squamous Cell; Case-Control Studies; Cysteine; DNA Glycosylases; Esophageal Neoplasms; Esophageal Squamous Cell Carcinoma; Esophagus; Female; Gene Frequency; Genetic Predisposition to Disease; Humans; Male; Middle Aged; Models, Genetic; Odds Ratio; Polymorphism, Genetic; Risk; Serine | 2013 |
Insights into the evolution of lanthipeptide biosynthesis.
Topics: Alanine; Amino Acids; Bacterial Proteins; Cyclization; Cysteine; Evolution, Molecular; Hydro-Lyases; Multienzyme Complexes; Peptides, Cyclic; Protein Processing, Post-Translational; Serine; Sulfides; Threonine | 2013 |
Formylglycine, a post-translationally generated residue with unique catalytic capabilities and biotechnology applications.
Topics: Alanine; Animals; Binding Sites; Biotechnology; Catalysis; Catalytic Domain; Cysteine; Glycine; Humans; Models, Molecular; Protein Processing, Post-Translational; Serine; Sulfotransferases | 2015 |
Meta-analysis of the influence of dietary glycine and serine, with consideration of methionine and cysteine, on growth and feed conversion of broilers.
Topics: Amino Acids; Animal Feed; Animal Nutritional Physiological Phenomena; Animals; Chickens; Cysteine; Diet; Glycine; Methionine; Serine | 2015 |
[A novel pathway to produce hydrogen sulfide].
Topics: Animals; Cysteine; Cysteine Synthase; Cytoprotection; Enzymes; Humans; Hydrogen Sulfide; Serine | 2015 |
Nonessential amino acid metabolism in breast cancer.
Topics: Animals; Arginine; Breast Neoplasms; Cysteine; Diet Therapy; Female; Food Deprivation; Glutamic Acid; Glutamine; Glycine; Humans; Metabolic Networks and Pathways; Proline; Serine | 2016 |
Metabolism of Sulfur-Containing Amino Acids: How the Body Copes with Excess Methionine, Cysteine, and Sulfide.
Topics: Amino Acid Metabolism, Inborn Errors; Amino Acids; Animals; Cystathionine beta-Synthase; Cysteine; Glycine N-Methyltransferase; Homocysteine; Humans; Hydrogen Sulfide; Liver; Methionine; S-Adenosylmethionine; Serine; Sulfides; Sulfur; Thiosulfates | 2020 |
The Possible Mechanism of Physiological Adaptation to the Low-Se Diet and Its Health Risk in the Traditional Endemic Areas of Keshan Diseases.
Topics: Adaptation, Physiological; Animals; Cardiomyopathies; Cysteine; Diet; Enterovirus Infections; Selenium; Selenocysteine; Selenoproteins; Serine | 2022 |
Chinese Cordyceps: Bioactive Components, Antitumor Effects and Underlying Mechanism-A Review.
Topics: Adenosine; Antineoplastic Agents; Biological Products; Caspases; China; Cordyceps; Cysteine; Immunologic Factors; Mitogen-Activated Protein Kinases; NF-kappa B; Proto-Oncogene Proteins c-akt; Serine | 2022 |
3 trial(s) available for cysteine and serine
| Article | Year |
|---|---|
Association of structural polymorphism of the dopamine D2 receptor gene and alcoholism.
Topics: Age of Onset; Alcoholism; Alleles; Amino Acid Sequence; Base Sequence; Cysteine; DNA Primers; Exons; Female; Genetic Carrier Screening; Homozygote; Humans; Male; Middle Aged; Molecular Sequence Data; Point Mutation; Polymerase Chain Reaction; Polymorphism, Genetic; Receptors, Dopamine D2; Reference Values; Serine | 1994 |
hOGG1 Ser326Cys polymorphism and breast cancer risk among Asian women.
Topics: Adult; Aged; Amino Acid Substitution; Asian People; Breast Neoplasms; Case-Control Studies; Cysteine; DNA Glycosylases; DNA, Neoplasm; Female; Gene Frequency; Genetic Predisposition to Disease; Humans; Japan; Korea; Logistic Models; Middle Aged; Polymorphism, Genetic; Risk Factors; Serine | 2003 |
Neuroimaging and 5-HT2C receptor polymorphism: a HMPAO-SPECT study in healthy male probands using mCPP-challenge of the 5-HT2C receptor.
Topics: Adult; Anxiety; Brain; Brain Mapping; Cerebrovascular Circulation; Cysteine; Demography; Double-Blind Method; Humans; Image Processing, Computer-Assisted; Male; Piperazines; Polymorphism, Genetic; Receptor, Serotonin, 5-HT2C; Serine; Serotonin Receptor Agonists; Technetium Tc 99m Exametazime; Tomography, Emission-Computed, Single-Photon | 2004 |
1377 other study(ies) available for cysteine and serine
| Article | Year |
|---|---|
Sulphur metabolism in Paracoccus denitrificans. Purification, properties and regulation of serine transacetylase, O-acetylserine sulphydrylase and beta-cystathionase.
Topics: Acetyl Coenzyme A; Acetyltransferases; Cystathionine gamma-Lyase; Cysteine; Cysteine Synthase; Hydrogen-Ion Concentration; Lyases; Paracoccus denitrificans; Selenium; Serine; Sulfhydryl Reagents | 1977 |
Conversion of the active-site cysteine residue of papain into a dehydro-serine, a serine and a glycine residue.
Topics: Acetophenones; Binding Sites; Cysteine; Glycine; Hydrogen-Ion Concentration; Papain; Photolysis; Serine; Spectrometry, Fluorescence | 1978 |
The anticlastogenic effect of various combinations of cysteamine, AET, HCT, and amino acids on chromosome damage by trenimon and bleomycin in human lymphocytes in vitro.
Topics: Alkylating Agents; Amino Acids, Sulfur; Aspartic Acid; beta-Aminoethyl Isothiourea; Bleomycin; Chromosome Aberrations; Chromosomes; Cysteamine; Cysteine; Lactones; Methionine; Mutagens; Serine; Triaziquone | 1978 |
Molecular orbital studies on serine, cysteine, and modified proteases.
Topics: Chemical Phenomena; Chemistry, Physical; Cysteine; Molecular Conformation; Peptide Hydrolases; Protein Conformation; Serine | 1977 |
The behavioral effects of L-methionine and related compounds in rats and mice.
Topics: Animals; Avoidance Learning; Behavior, Animal; Betaine; Brain; Brain Chemistry; Circadian Rhythm; Conditioning, Operant; Cysteine; Electroencephalography; Eye Movements; Histidine; Homocysteine; Methionine; Mice; Mice, Inbred C57BL; Niacinamide; Rats; Serine; Sleep; Sleep, REM; Wakefulness | 1975 |
O-acetylserine and O-acetylhomoserine sulfhydrylase of yeast; studies with methionine auxotrophs.
Topics: Cysteine; Genetics, Microbial; Homoserine; Hydrogen-Ion Concentration; Kinetics; Lyases; Methionine; Molecular Biology; Mutation; Saccharomyces cerevisiae; Serine | 1975 |
L-serine dehydratase from Arthrobacter globiformis.
Topics: Arthrobacter; Bacteriological Techniques; Cell-Free System; Chromatography, Gel; Cysteine; Electrolytes; Electrophoresis, Polyacrylamide Gel; Kinetics; L-Serine Dehydratase; Mercury; Pyruvates; Serine; Toluene | 1977 |
Isolation of a lambdadcys transducing bacteriophage and its use in determining the regulation of cysteine messenger ribonucleic acid synthesis in Escherichia coli K-12.
Topics: Bacterial Proteins; Coliphages; Cysteine; Escherichia coli; Genes; Nucleic Acid Hybridization; RNA, Bacterial; RNA, Messenger; Serine; Transduction, Genetic | 1977 |
Cysteinyl-tRNA synthetase from Escherichia coli does not need an editing mechanism to reject serine and alanine. High binding energy of small groups in specific molecular interactions.
Topics: Alanine; Amino Acyl-tRNA Synthetases; Cysteine; Escherichia coli; Kinetics; Protein Binding; Serine; Substrate Specificity | 1979 |
Thioltrypsin. Chemical transformation of the active-site serine residue of Streptomyces griseus trypsin to a cysteine residue.
Topics: Binding Sites; Catalysis; Cysteine; Serine; Streptomyces griseus; Structure-Activity Relationship; Sulfhydryl Compounds; Trypsin; Trypsin Inhibitors | 1977 |
Cysteine biosynthesis in a fungus, Histoplasma capsulatum.
Topics: Chloramphenicol; Cycloheximide; Cysteine; Histoplasma; Serine | 1979 |
Maintenance of glutathione content is isolated hepatocyctes.
Topics: Animals; Cell Separation; Cysteine; Female; Glutathione; Homocysteine; In Vitro Techniques; Liver; Methionine; Rats; Serine | 1978 |
Mechanism of the reaction of papain with substrate-derived diazomethyl ketones. Implications for the difference in site specificity of halomethyl ketones for serine proteinases and cysteine proteinases and for stereoelectronic requirements in the papain c
Topics: Amino Acid Chloromethyl Ketones; Binding Sites; Cysteine; Diazomethane; Endopeptidases; Ketones; Models, Chemical; Molecular Conformation; Papain; Serine | 1978 |
A reaction mechanism from steady state kinetic studies for O-acetylserine sulfhydrylase from Salmonella typhimurium LT-2.
Topics: Cysteine; Kinetics; Lyases; Mathematics; Protein Conformation; Salmonella typhimurium; Serine; Spectrophotometry; Spectrophotometry, Ultraviolet; Sulfides | 1976 |
Receptors for chemotaxis in Bacillus subtilis.
Topics: Amino Acids; Bacillus subtilis; Chemotaxis; Cysteine; Methionine; Receptors, Drug; Serine; Structure-Activity Relationship | 1975 |
Comparison of transport at the anterior and posterior surfaces of the calf lens.
Topics: Alanine; Amino Acids; Animals; Arginine; Biological Transport; Cattle; Cysteine; Epithelium; gamma-Aminobutyric Acid; Glycine; In Vitro Techniques; Kinetics; Lens, Crystalline; Leucine; Serine | 1977 |
Peptide aldehydes: potent inhibitors of serine and cysteine proteases.
Topics: Aldehydes; Cysteine; Methods; Peptides; Protease Inhibitors; Serine; Structure-Activity Relationship | 1977 |
On the introduction of disulfide crosslinks into fibrous proteins and bovine serum albumin.
Topics: Amino Acids; Chemical Phenomena; Chemistry; Collagen; Cysteine; Cystine; Disulfides; Fibroins; Kinetics; Macromolecular Substances; Methionine; Protein Conformation; Serine; Serum Albumin, Bovine; Temperature; Tosyl Compounds | 1977 |
Rotatory characteristics of the beta-structure in non-aqueous solution.
Topics: Benzyl Compounds; Circular Dichroism; Cysteine; Optical Rotatory Dispersion; Peptides; Protein Conformation; Serine; Spectrophotometry, Ultraviolet | 1976 |
Specificity of ethacrynic acid as a sulfhydryl reagent.
Topics: Cysteine; Ethacrynic Acid; Histidine; Imidazoles; L-Lactate Dehydrogenase; Lysine; Serine; Sulfhydryl Reagents | 1976 |
Stereochemistry of the reaction of sheep liver threonine dehydratase. A nuclear magnetic resonance and optical rotatory dispersion study of its reaction pathway and products.
Topics: Alanine; Animals; Butyrates; Cysteine; Hydro-Lyases; Keto Acids; Liver; Magnetic Resonance Spectroscopy; Optical Rotatory Dispersion; Propionates; Serine; Sheep; Stereoisomerism; Threonine; Threonine Dehydratase | 1976 |
Evidence for S-adenosylmethionine independent catabolism of methionine in the rat.
Topics: Animals; Carbon Dioxide; Cysteine; Formaldehyde; Formates; Glycine; Liver; Male; Methionine; Rats; S-Adenosylmethionine; Serine | 1976 |
Studies on the mechanism of inhibition of Salmonella typhimurium by 1,2,4-triazole.
Topics: Cysteine; Enzyme Repression; Kinetics; Lyases; Salmonella typhimurium; Serine; Triazoles | 1975 |
Fine-structure genetic map of the cysB locus in Salmonella typhimurium.
Topics: Acetyltransferases; Chromosome Mapping; Crosses, Genetic; Cystathionine beta-Synthase; Cysteine; Cystine; Genes; Mutation; Salmonella typhimurium; Serine; Transduction, Genetic | 1975 |
Cysteine biosynthesis in Aspergillus nidulans.
Topics: Aspergillus nidulans; Cysteine; Lyases; Methionine; Mutation; Serine | 1975 |
The cleavage of the ether linkage of O-methyl serine by the alkyl cysteine lyase of Acacia farnesiana.
Topics: Catalysis; Cysteine; Kinetics; Lyases; Plants; Serine; Structure-Activity Relationship | 1975 |
Ligand-exchange chromatography of amino acids on copper-, cobalt- and zinc-chelex 100.
Topics: Amino Acids; Ammonia; Arginine; Aspartic Acid; Chromatography, Ion Exchange; Cobalt; Copper; Cysteine; Glutamates; Histidine; Ion Exchange Resins; Ligands; Lysine; Phenylalanine; Quaternary Ammonium Compounds; Serine; Threonine; Tyrosine; Zinc | 1975 |
Cysteine synthase from rape leaves.
Topics: Chromatography, Gel; Cysteine; Kinetics; Lyases; Macromolecular Substances; Molecular Weight; Plants; Protein Conformation; Pyridoxal Phosphate; Serine; Subcellular Fractions | 1975 |
Histone III. VI. Two forms of calf thymus histone III.
Topics: Amino Acid Sequence; Amino Acids; Animals; Carboxypeptidases; Cattle; Chymotrypsin; Cysteine; Histones; Protein Conformation; Serine; Thymus Gland | 1975 |
Isotopic hydrogen exchange in reactions catalysed by cysteine lyase and serine sulphhydrase.
Topics: Animals; Carbon-Sulfur Lyases; Chick Embryo; Cystathionine beta-Synthase; Cysteine; Female; Isotope Labeling; Kinetics; Lyases; Oxygen Isotopes; Serine; Time Factors; Tritium; Vitelline Membrane | 1975 |
[Reaction of 1,2-diphenyl-4-bis-(methylthio)methylenepyrazolidin-3,5-dione with serine, cysteine and their derivatives].
Topics: Animals; Anti-Inflammatory Agents; Cysteine; Indicators and Reagents; Pyrazoles; Rats; Serine; Serotonin Antagonists | 1975 |
[Some indices of nitrogen metabolism in patients with viral hepatitis].
Topics: Adolescent; Adult; Alanine; Ammonia; Asparagine; Chronic Disease; Cysteine; Cystinuria; Glutamates; Glycine; Hepatitis A; Humans; Isoleucine; Leucine; Methionine; Middle Aged; Nitrogen; Phenylalanine; Serine; Threonine; Urea; Valine | 1975 |
[Free amino acids in the amniotic fluid and in maternal blood in advanced pregnancy].
Topics: Alanine; Amino Acids; Amniotic Fluid; Cysteine; Female; Glycine; Histidine; Humans; Isoleucine; Leucine; Lysine; Methionine; Ornithine; Phenylalanine; Pregnancy; Pregnancy Trimester, Third; Proline; Serine; Threonine; Tyrosine; Valine | 1975 |
Nutrition of Vitreoscilla stercoraria.
Topics: Alanine; Amino Acids; Aspartic Acid; Cysteine; Glutamates; Glutamine; Proline; Serine; Thiotrichaceae | 1975 |
Retinal degeneration in cats fed casein. I. Taurine deficiency.
Topics: Animals; Caseins; Cats; Cysteine; Dietary Proteins; DNA; Eating; Electroretinography; Glutamine; Glycine; Methionine; Retina; Retinal Degeneration; Serine; Taurine | 1976 |
Studies on trypsin inhibitors. Part I. Synthesis of protected peptides related to sequence 1-10 of porcine pancreatic secretory trypsin inhibitor II (Kazal).
Topics: Alanine; Animals; Arginine; Cysteine; Glutamine; Peptides; Proline; Serine; Swine; Threonine; Trypsin Inhibitor, Kazal Pancreatic; Trypsin Inhibitors; Valine | 1976 |
[The pattern of distribution of free amino acids in human amniotic fluid related to the duration of pregnancy. Part I: Changes in concentration in normal pregnancy (author's transl)].
Topics: Alanine; Amino Acids; Amniotic Fluid; Chromatography, Gas; Cysteine; Female; Gestational Age; Glycine; Humans; Hydroxyproline; Methionine; Ornithine; Pregnancy; Pregnancy Trimester, Second; Pregnancy Trimester, Third; Serine; Threonine; Tryptophan; Tyrosine; Valine | 1976 |
Free energy perturbation study on a Trp-binding mutant (Ser88-->Cys) of the trp-repressor.
Topics: Bacterial Proteins; Computer Simulation; Computers; Cysteine; Escherichia coli; Models, Molecular; Mutation; Protein Conformation; Repressor Proteins; Serine; Software; Structure-Activity Relationship; Thermodynamics; Tryptophan | 1992 |
Thiolate ligation of the active site Fe2+ of isopenicillin N synthase derives from substrate rather than endogenous cysteine: spectroscopic studies of site-specific Cys----Ser mutated enzymes.
Topics: Acremonium; Amino Acid Sequence; Binding Sites; Cysteine; Electron Spin Resonance Spectroscopy; Iron; Molecular Sequence Data; Mutagenesis, Site-Directed; Nitrous Oxide; Oxidoreductases; Penicillins; Photochemistry; Serine; Structure-Activity Relationship; Substrate Specificity; Sulfhydryl Compounds; Water | 1992 |
Serine residues responsible for tetracycline transport are on a vertical stripe including Asp-84 on one side of transmembrane helix 3 in transposon Tn10-encoded tetracycline/H+ antiporter of Escherichia coli.
Topics: Alanine; Amino Acid Sequence; Antiporters; Aspartic Acid; Bacterial Proteins; Base Sequence; Biological Transport; Carrier Proteins; Cell Membrane; Cysteine; DNA Transposable Elements; DNA, Bacterial; Escherichia coli; Immunoblotting; Kinetics; Molecular Sequence Data; Mutagenesis, Site-Directed; Repressor Proteins; Serine; Tetracycline; Threonine | 1992 |
Expression of bovine adrenodoxin in E. coli and site-directed mutagenesis of /2 Fe-2S/ cluster ligands.
Topics: Adrenodoxin; Animals; Base Sequence; Biological Transport; Cattle; Cloning, Molecular; Cysteine; Cytoplasm; DNA Mutational Analysis; Electron Spin Resonance Spectroscopy; Escherichia coli; Gene Expression; Ligands; Molecular Sequence Data; Mutagenesis, Site-Directed; Recombinant Proteins; Serine; Structure-Activity Relationship; Transfection | 1992 |
Role of cysteine residues in the extracellular domain and exoplasmic loops of the transmembrane domain of the TSH receptor: effect of mutation to serine on TSH receptor activity and response to thyroid stimulating autoantibodies.
Topics: Animals; Autoantibodies; Binding, Competitive; Blotting, Western; Cell Line; Cell Membrane; Cyclic AMP; Cysteine; Graves Disease; Humans; Kinetics; Molecular Weight; Mutagenesis, Site-Directed; Plasmids; Protein Structure, Secondary; Rats; Receptors, Thyrotropin; Recombinant Proteins; Sequence Deletion; Serine; Thyroid Gland; Thyrotropin; Transfection | 1992 |
Biosynthetic thiolase from Zoogloea ramigera. Mutagenesis of the putative active-site base Cys-378 to Ser-378 changes the partitioning of the acetyl S-enzyme intermediate.
Topics: Acetyl-CoA C-Acetyltransferase; Acetylation; Amino Acid Sequence; Binding Sites; Circular Dichroism; Cysteine; Kinetics; Molecular Sequence Data; Mutagenesis, Site-Directed; Protein Conformation; Pseudomonadaceae; Serine | 1992 |
Cysteine to serine substitutions in basic fibroblast growth factor: effect on inclusion body formation and proteolytic susceptibility during in vitro refolding.
Topics: Base Sequence; Cell Fractionation; Cysteine; Electrophoresis, Polyacrylamide Gel; Escherichia coli; Fermentation; Fibroblast Growth Factor 2; Hot Temperature; Humans; Molecular Sequence Data; Mutagenesis, Site-Directed; Peptide Hydrolases; Plasmids; Protein Conformation; Serine; Solubility | 1992 |
Folding and oxidation of recombinant human granulocyte colony stimulating factor produced in Escherichia coli. Characterization of the disulfide-reduced intermediates and cysteine----serine analogs.
Topics: Chromatography, High Pressure Liquid; Circular Dichroism; Copper; Copper Sulfate; Cysteine; Escherichia coli; Fluorescence Polarization; Granulocyte Colony-Stimulating Factor; Humans; Kinetics; Oxidation-Reduction; Protein Conformation; Receptors, Granulocyte Colony-Stimulating Factor; Recombinant Proteins; Serine; Spectrophotometry, Ultraviolet | 1992 |
Disulfide-bonded discontinuous epitopes on the glycoprotein of vesicular stomatitis virus (New Jersey serotype).
Topics: Animals; Antibodies, Monoclonal; Cysteine; Disulfides; DNA Mutational Analysis; Epitopes; Glycoproteins; Membrane Glycoproteins; Mutagenesis, Site-Directed; Peptide Fragments; Peptide Mapping; Protein Conformation; Recombinant Proteins; Serine; Vesiculovirus; Viral Envelope Proteins | 1992 |
Purification and characterization of O-acetylserine (thiol) lyase from spinach chloroplasts.
Topics: Acetyltransferases; Amino Acids; Blotting, Western; Chloroplasts; Chromatography, Liquid; Cross Reactions; Cysteine; Cysteine Synthase; Electrophoresis, Polyacrylamide Gel; Epitopes; Mitochondria; Plants; Pyridoxal Phosphate; Serine; Serine O-Acetyltransferase; Spectrometry, Fluorescence | 1992 |
F1-ATPase with cysteine instead of serine at residue 373 of the alpha subunit.
Topics: Amino Acid Sequence; Cell Membrane; Cysteine; Escherichia coli; Ethylmaleimide; Genotype; Kinetics; Macromolecular Substances; Proton-Translocating ATPases; Serine; Species Specificity | 1992 |
The helix-loop-helix/leucine repeat transcription factor USF can be functionally regulated in a redox-dependent manner.
Topics: Amino Acid Sequence; Base Sequence; Binding Sites; Cysteine; DNA-Binding Proteins; Macromolecular Substances; Molecular Sequence Data; Mutagenesis, Site-Directed; Oligodeoxyribonucleotides; Oxidation-Reduction; Promoter Regions, Genetic; Protein Structure, Secondary; Recombinant Proteins; Restriction Mapping; Serine; Transcription Factors; Transcription, Genetic; Upstream Stimulatory Factors | 1992 |
The crystal structure of the aldose reductase.NADPH binary complex.
Topics: Aldehyde Reductase; Amino Acid Sequence; Binding Sites; Cloning, Molecular; Cysteine; Escherichia coli; Humans; Models, Molecular; Mutagenesis, Site-Directed; NADP; Oxidation-Reduction; Protein Conformation; Recombinant Proteins; Serine | 1992 |
Detection of an enzyme bound gamma-glutamyl acyl ester of carbamyl phosphate synthetase of Escherichia coli.
Topics: Acids; Binding Sites; Carbamoyl-Phosphate Synthase (Glutamine-Hydrolyzing); Cysteine; Escherichia coli; Esters; Glutamates; Glutamine; Hydrolysis; Hydroxamic Acids; Kinetics; Mutation; Pyrrolidonecarboxylic Acid; Serine | 1992 |
Leucine and serine induce mecillinam resistance in Escherichia coli.
Topics: Amdinocillin; Cysteine; Escherichia coli; Genes, Bacterial; Guanosine Tetraphosphate; Isoleucine; Leucine; Penicillin Resistance; Serine; Valine | 1992 |
The role of anticodon bases and the discriminator nucleotide in the recognition of some E. coli tRNAs by their aminoacyl-tRNA synthetases.
Topics: Amino Acyl-tRNA Synthetases; Anticodon; Asparagine; Bacteriophage T7; Base Sequence; Cysteine; DNA-Directed RNA Polymerases; Escherichia coli; Glycine; Histidine; Molecular Sequence Data; Nucleic Acid Conformation; RNA, Transfer; Serine; Structure-Activity Relationship; Substrate Specificity | 1992 |
Utilization of an active serine 101----cysteine mutant to demonstrate the proximity of the catalytic serine 101 and histidine 237 residues in thioesterase II.
Topics: Amino Acid Sequence; Animals; Base Sequence; Binding Sites; Catalysis; Chromatography, High Pressure Liquid; Cross-Linking Reagents; Cysteine; DNA; Fatty Acid Synthases; Histidine; Kinetics; Mass Spectrometry; Molecular Sequence Data; Mutation; Propane; Rats; Serine; Thiolester Hydrolases | 1992 |
Immunoglobulin E-binding site in Fc epsilon receptor (Fc epsilon RII/CD23) identified by homolog-scanning mutagenesis.
Topics: Amino Acid Sequence; Antibodies, Monoclonal; Antigens, Differentiation, B-Lymphocyte; Base Sequence; Binding Sites; Blotting, Western; Cysteine; Disulfides; Humans; Immunoglobulin E; Molecular Sequence Data; Mutagenesis; Phenotype; Protein Conformation; Receptors, Fc; Receptors, IgE; Sequence Homology, Nucleic Acid; Serine | 1992 |
Serine-376 contributes to the binding of substrate by ribulose-bisphosphate carboxylase/oxygenase from Anacystis nidulans.
Topics: Alanine; Amino Acid Sequence; Binding Sites; Cyanobacteria; Cysteine; Enzyme Activation; Kinetics; Mutagenesis, Site-Directed; Protein Binding; Ribulose-Bisphosphate Carboxylase; Serine; Substrate Specificity; Threonine | 1992 |
Enzymatic synthesis of S-aminoethyl-L-cysteine from pantetheine.
Topics: Amidohydrolases; Amino Acid Oxidoreductases; Amino Acids, Sulfur; Cystathionine beta-Synthase; Cysteamine; Cysteine; GPI-Linked Proteins; L-Amino Acid Oxidase; Pantetheine; Serine | 1992 |
Cysteine 647 in the insulin receptor is required for normal covalent interaction between alpha- and beta-subunits and signal transduction.
Topics: Affinity Labels; Animals; Base Sequence; CHO Cells; Cricetinae; Cross-Linking Reagents; Cysteine; Dithiothreitol; DNA; Electrophoresis, Polyacrylamide Gel; Insulin; Iodine Radioisotopes; Molecular Sequence Data; Mutagenesis, Site-Directed; Mutation; Phosphorylation; Precipitin Tests; Receptor, Insulin; Serine; Signal Transduction; Transfection | 1992 |
Purification and properties of a recombinant sulfur analog of murine selenium-glutathione peroxidase.
Topics: Animals; Chromatography, Gel; Chromatography, High Pressure Liquid; Cysteine; Electrophoresis, Polyacrylamide Gel; Escherichia coli; Genes, Bacterial; Glutathione Peroxidase; Hydrogen-Ion Concentration; Isoelectric Focusing; Mice; Mutation; Recombinant Proteins; Serine; Sulfur | 1992 |
Conversion of bovine growth hormone cysteine residues to serine affects secretion by cultured cells and growth rates in transgenic mice.
Topics: Amino Acid Sequence; Animals; Blotting, Western; Body Weight; Cattle; Cells, Cultured; Cysteine; Disulfides; Fluorescent Antibody Technique; Growth; Growth Hormone; L Cells; Mice; Mice, Transgenic; Mutagenesis, Site-Directed; Receptors, Somatotropin; Recombinant Proteins; Restriction Mapping; Serine | 1992 |
Identification of a prenylation site in delta virus large antigen.
Topics: 3T3 Cells; Amino Acid Sequence; Animals; Antigens, Viral; Cell Line; Cysteine; Hepatitis delta Antigens; Hepatitis Delta Virus; Mevalonic Acid; Mice; Molecular Sequence Data; Mutagenesis, Site-Directed; Proline; Protein Biosynthesis; Rabbits; Reticulocytes; RNA, Messenger; Serine; Transfection; Virus Replication | 1992 |
The RxxRxRxxC motif conserved in all Rel/kappa B proteins is essential for the DNA-binding activity and redox regulation of the v-Rel oncoprotein.
Topics: Base Sequence; Binding Sites; Consensus Sequence; Cysteine; DNA Mutational Analysis; DNA-Binding Proteins; Humans; Molecular Sequence Data; Multigene Family; Mutagenesis, Site-Directed; Oncogene Proteins v-rel; Oncogenes; Oxidation-Reduction; Retroviridae Proteins, Oncogenic; Serine; Transcription, Genetic; Transformation, Genetic | 1992 |
Structure determination of the Antp (C39----S) homeodomain from nuclear magnetic resonance data in solution using a novel strategy for the structure calculation with the programs DIANA, CALIBA, HABAS and GLOMSA.
Topics: Algorithms; Amino Acid Sequence; Animals; Antennapedia Homeodomain Protein; Cysteine; DNA-Binding Proteins; Drosophila melanogaster; Drosophila Proteins; Genes, Homeobox; Homeodomain Proteins; Magnetic Resonance Spectroscopy; Models, Molecular; Molecular Sequence Data; Mutation; Nuclear Proteins; Protein Conformation; Serine; Software; Stereoisomerism; Structure-Activity Relationship; Thermodynamics; Transcription Factors | 1991 |
Single base mutation in alpha 5(IV) collagen chain gene converting a conserved cysteine to serine in Alport syndrome.
Topics: Bacterial Proteins; Base Sequence; Blotting, Southern; Collagen; Cysteine; Deoxyribonucleases, Type II Site-Specific; Female; Genes; Humans; Male; Molecular Sequence Data; Mutation; Nephritis, Hereditary; Polymerase Chain Reaction; Polymorphism, Restriction Fragment Length; Restriction Mapping; Serine | 1991 |
Conversion of cysteine to serine residues alters the activity, stability, and heparin dependence of acidic fibroblast growth factor.
Topics: Blotting, Western; Cysteine; Fibroblast Growth Factor 1; Heparin; Humans; Hydrogen-Ion Concentration; Mitogens; Mutation; Serine; Temperature | 1991 |
Role of an evolutionarily invariant serine for the stability of human carbonic anhydrase II.
Topics: Alanine; Binding Sites; Biological Evolution; Carbonic Anhydrases; Cysteine; Erythrocytes; Humans; Mutation; Protein Conformation; Serine | 1992 |
A single amino acid mutation (Ser180----Cys) determines the polymorphism in cytochrome P450g (P4502C13) by altering protein stability.
Topics: Amino Acid Sequence; Animals; Base Sequence; Blotting, Western; Cloning, Molecular; Cysteine; Cytochrome P-450 Enzyme System; DNA; Enzyme Stability; Kinetics; Molecular Sequence Data; Mutagenesis, Site-Directed; Oligodeoxyribonucleotides; Phenotype; Plasmids; Polymorphism, Genetic; Rats; Recombinant Proteins; Restriction Mapping; Saccharomyces cerevisiae; Serine | 1992 |
Site-directed chemical conversion of serine to cysteine in penicillin acylase from Escherichia coli ATCC 11105. Effect on conformation and catalytic activity.
Topics: Amino Acid Sequence; Circular Dichroism; Cysteine; Escherichia coli; Hydrogen-Ion Concentration; Kinetics; Molecular Sequence Data; Penicillanic Acid; Penicillin Amidase; Phenylmethylsulfonyl Fluoride; Protein Conformation; Pyridines; Serine; Sulfur Radioisotopes | 1991 |
A nonconservative serine to cysteine mutation in the sulfate-binding protein, a transport receptor.
Topics: Bacterial Proteins; Binding Sites; Carrier Proteins; Cysteine; DNA Mutational Analysis; Escherichia coli Proteins; Hydrogen Bonding; Hydrogen-Ion Concentration; Models, Molecular; Periplasmic Binding Proteins; Salmonella typhimurium; Serine; Structure-Activity Relationship; Sulfates; Thermodynamics | 1991 |
Structure-function studies of human interferons-alpha: enhanced activity on human and murine cells.
Topics: Animals; Cattle; Cells, Cultured; Cysteine; Humans; In Vitro Techniques; Interferon Type I; Mutagenesis, Site-Directed; Rabbits; Reticulocytes; Serine; Structure-Activity Relationship | 1991 |
Characterization of the mutation responsible for aspartylglucosaminuria in three Finnish patients. Amino acid substitution Cys163----Ser abolishes the activity of lysosomal glycosylasparaginase and its conversion into subunits.
Topics: Acetylglucosamine; Amino Acid Sequence; Aspartylglucosylaminase; Base Sequence; Blotting, Northern; Blotting, Southern; Cysteine; DNA; Fibroblasts; Finland; Humans; Lysosomes; Molecular Sequence Data; Mutation; Polymerase Chain Reaction; Protein Biosynthesis; Restriction Mapping; RNA, Messenger; Serine | 1991 |
Crystal structure of rat trypsin-S195C at -150 degrees C. Analysis of low activity of recombinant and semisynthetic thiol proteases.
Topics: Amino Acid Sequence; Animals; Binding Sites; Cysteine; Cysteine Endopeptidases; Freezing; Models, Molecular; Molecular Sequence Data; Mutagenesis, Site-Directed; Protein Conformation; Rats; Recombinant Proteins; Serine; Trypsin; X-Ray Diffraction | 1991 |
Inhibition of homoserine dehydrogenase I by L-serine in Escherichia coli.
Topics: Cations, Monovalent; Cysteine; Escherichia coli; Homoserine Dehydrogenase; Hydrogen-Ion Concentration; Kinetics; Potassium; Serine; Threonine | 1991 |
The cysP promoter of Salmonella typhimurium: characterization of two binding sites for CysB protein, studies of in vivo transcription initiation, and demonstration of the anti-inducer effects of thiosulfate.
Topics: Bacterial Proteins; Base Sequence; Binding Sites; Cysteine; DNA, Bacterial; Gene Expression Regulation, Bacterial; Molecular Sequence Data; Oligonucleotides; Polymerase Chain Reaction; Promoter Regions, Genetic; Salmonella typhimurium; Sequence Homology, Nucleic Acid; Serine; Sulfides; Thiosulfates; Transcription, Genetic | 1991 |
Analysis of neutral amino acid transport systems in the small intestine: a study of brush border membrane vesicles.
Topics: Alanine; Amino Acids; Animals; Biological Transport; Culture Media; Cysteine; Guinea Pigs; Ileum; In Vitro Techniques; Leucine; Microvilli; Proline; Serine | 1991 |
The yeast RME1 gene encodes a putative zinc finger protein that is directly repressed by a1-alpha 2.
Topics: Amino Acid Sequence; Base Sequence; beta-Galactosidase; Consensus Sequence; Cysteine; DNA Mutational Analysis; Fungal Proteins; Gene Expression Regulation, Fungal; Genes, Fungal; Immunoblotting; Meiosis; Molecular Sequence Data; Plasmids; Recombinant Fusion Proteins; Regulatory Sequences, Nucleic Acid; Repressor Proteins; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Sequence Homology, Nucleic Acid; Serine; Zinc Fingers | 1991 |
Role of hepatic gamma-glutamyltransferase in the degradation of circulating glutathione: studies in the intact guinea pig perfused liver.
Topics: Animals; Borates; Cysteine; Dipeptides; gamma-Glutamyltransferase; Glutathione; Guinea Pigs; Isoxazoles; Liver; Perfusion; Serine | 1990 |
Role of cysteine and taurine in regulating glutathione synthesis by periportal and perivenous hepatocytes.
Topics: Amino Acids; Animals; Cysteine; Digitonin; Glutamate-Cysteine Ligase; Glutamine; Glutathione; Intracellular Fluid; Liver; Male; Methionine; Portal System; Portal Vein; Rats; Serine; Sulfates; Sulfur; Sulfur Radioisotopes; Taurine | 1990 |
In vitro interactions of CysB protein with the cysJIH promoter of Salmonella typhimurium: inhibitory effects of sulfide.
Topics: Bacterial Proteins; Cloning, Molecular; Cysteine; Escherichia coli; Genes, Bacterial; Genes, Regulator; Plasmids; Promoter Regions, Genetic; Restriction Mapping; Salmonella typhimurium; Serine; Sulfides; Transcription, Genetic | 1990 |
Evidence for reactivity of serine-74 with trans-4-(N,N-dimethylamino)cinnamaldehyde during oxidation by the cytoplasmic aldehyde dehydrogenase from sheep liver.
Topics: Aldehyde Dehydrogenase; Amino Acid Sequence; Animals; Binding Sites; Cinnamates; Cysteine; Cytoplasm; Iodoacetamide; Liver; Molecular Sequence Data; Serine; Sheep; Thermolysin | 1990 |
A point mutation in the tyrosinase gene of BALB/c albino mouse causing the cysteine----serine substitution at position 85.
Topics: Albinism; Animals; Base Sequence; Catechol Oxidase; Cysteine; Exons; Gene Amplification; Gene Library; Mice; Mice, Inbred BALB C; Molecular Sequence Data; Monophenol Monooxygenase; Mutation; Oligonucleotide Probes; Phenotype; Promoter Regions, Genetic; Restriction Mapping; Serine | 1990 |
Inhibition of GSH efflux from rat liver by methionine: effects of GSH synthesis in cells and perfused organ.
Topics: Alkynes; Amino Acids; Animals; Cells, Cultured; Cysteine; Glutathione; Glycine; Homocysteine; Kinetics; Liver; Male; Methionine; Pargyline; Perfusion; Rats; Rats, Inbred Strains; Serine | 1990 |
Role of the transsulfuration pathway and of gamma-cystathionase activity in the formation of cysteine and sulfate from methionine in rat hepatocytes.
Topics: Alkynes; Animals; Cystathionine gamma-Lyase; Cysteine; Glutathione; Glycine; Kinetics; Liver; Lyases; Male; Methionine; Pargyline; Rats; Rats, Inbred Strains; Serine; Sulfates; Sulfur Radioisotopes; Taurine | 1990 |
Purification and characterization of Bacillus thuringiensis var. tenebrionis insecticidal proteins produced in E. coli.
Topics: Animals; Bacillus thuringiensis; Bacillus thuringiensis Toxins; Bacterial Proteins; Bacterial Toxins; Coleoptera; Cysteine; Endotoxins; Escherichia coli; Genes, Bacterial; Hemolysin Proteins; Mutation; Recombinant Proteins; Serine | 1990 |
Conserved cysteine to serine mutation in tyrosinase is responsible for the classical albino mutation in laboratory mice.
Topics: Albinism; Animals; Base Sequence; Blotting, Southern; Cloning, Molecular; Cysteine; Female; Male; Melanins; Mice; Mice, Transgenic; Molecular Sequence Data; Monophenol Monooxygenase; Mutation; Restriction Mapping; Serine | 1990 |
Mutations of the human papillomavirus type 16 E7 gene that affect transformation, transactivation and phosphorylation by the E7 protein.
Topics: Animals; Cell Line; Cell Transformation, Neoplastic; Cell Transformation, Viral; Cysteine; DNA Mutational Analysis; Humans; Mutation; Oncogene Proteins, Viral; Papillomaviridae; Papillomavirus E7 Proteins; Phosphorylation; Precipitin Tests; Rats; Serine; Specific Pathogen-Free Organisms; Transcriptional Activation; Transfection | 1990 |
Reversible import of apocytochrome c into mitochondria.
Topics: Alanine; Animals; Apoproteins; Biological Transport; Cysteine; Cytochrome c Group; Cytochromes c; Drosophila melanogaster; Kinetics; Mice; Mice, Inbred ICR; Mitochondria, Liver; Mutation; Protein Binding; Protein Biosynthesis; Serine; Transcription, Genetic | 1990 |
Evidence for two leukotriene receptor types in the guinea-pig isolated ileum.
Topics: Animals; Borates; Chromones; Cyclooxygenase Inhibitors; Cysteine; Dicarboxylic Acids; Guinea Pigs; Ileum; In Vitro Techniques; Indazoles; Indomethacin; Leukotriene E4; Male; Receptors, Immunologic; Receptors, Leukotriene; Serine; SRS-A; Stereoisomerism | 1990 |
Mechanism-based inhibition of a mutant Escherichia coli ribonucleotide reductase (cysteine-225----serine) by its substrate CDP.
Topics: Cloning, Molecular; Cysteine; Cytidine Diphosphate; Cytosine Nucleotides; Escherichia coli; Kinetics; Mutation; Ribonucleotide Reductases; Serine | 1989 |
Site-directed mutagenesis of the cysteinyl residues and the active-site serine residue of bacterial D-amino acid transaminase.
Topics: Bacillus; Base Sequence; Binding Sites; Cysteine; D-Alanine Transaminase; Dithionitrobenzoic Acid; Glycine; Kinetics; Macromolecular Substances; Molecular Sequence Data; Mutation; Serine; Transaminases | 1989 |
Characterization of a cysteine-free analog of recombinant human basic fibroblast growth factor.
Topics: Amino Acid Sequence; Animals; Cell Line; Circular Dichroism; Cysteine; Escherichia coli; Fibroblast Growth Factors; Genetic Vectors; Hydrogen-Ion Concentration; Mice; Oligonucleotide Probes; Recombinant Proteins; Serine; Spectrometry, Fluorescence; Thymidine | 1989 |
Fe:S cluster ligands are the only cysteines required for nitrogenase Fe-protein activities.
Topics: Adenosine Triphosphate; Azotobacter; Binding Sites; Chemical Phenomena; Chemistry; Cysteine; Iron-Sulfur Proteins; Kinetics; Macromolecular Substances; Metalloproteins; Molybdoferredoxin; Mutation; Nitrogenase; Oxidoreductases; Serine; Structure-Activity Relationship | 1989 |
Expression and site-specific mutagenesis of phospholamban. Studies of residues involved in phosphorylation and pentamer formation.
Topics: Amino Acid Sequence; Amino Acids; Animals; Calcium-Binding Proteins; Calmodulin; Cattle; Cell Line; Chlorocebus aethiops; Cysteine; DNA; Dogs; Kidney; Mutation; Phosphorylation; Protein Conformation; Protein Kinases; Serine; Threonine | 1989 |
Intermolecular disulfide bonds are not required for the expression of the dimeric state and functional activity of the transferrin receptor.
Topics: Animals; Antibodies, Monoclonal; Cell Line; Chemical Phenomena; Chemistry; Cricetinae; Cross-Linking Reagents; Cysteine; Disulfides; DNA; Electrophoresis, Polyacrylamide Gel; Gene Expression Regulation; Humans; Hydrogen-Ion Concentration; Kinetics; Macromolecular Substances; Mutation; Receptors, Transferrin; Serine; Structure-Activity Relationship; Transferrin | 1989 |
Serine to cysteine mutations in trp repressor protein alter tryptophan and operator binding.
Topics: Amino Acid Sequence; Anilino Naphthalenesulfonates; Bacterial Proteins; Binding Sites; Cysteine; Disulfides; DNA; Fluorescent Dyes; Molecular Sequence Data; Mutation; Naphthalenesulfonates; Operator Regions, Genetic; Repressor Proteins; Serine; Transcription Factors; Tryptophan | 1989 |
Coagulation factor XII (Hageman factor) Washington D.C.: inactive factor XIIa results from Cys-571----Ser substitution.
Topics: Amino Acid Sequence; Chromatography, High Pressure Liquid; Cysteine; Factor XII; Humans; Molecular Sequence Data; Mutation; Peptide Fragments; Peptide Mapping; Protein Conformation; Serine; Trypsin | 1989 |
Some observations on the replacement of the conserved amino acid residues of immunoglobulin domains.
Topics: Alanine; Amino Acids; beta 2-Microglobulin; Computer Graphics; Cysteine; Immunoglobulin Constant Regions; Immunoglobulin Variable Region; Immunoglobulins; Leucine; Serine; Tryptophan; Tyrosine | 1989 |
The effect of phosphorylation on the structure of alpha-crystallin.
Topics: Animals; Crystallins; Cysteine; Microscopy, Electron; Peptides; Phosphorylation; Polymers; Protein Conformation; Scattering, Radiation; Serine; Spectrometry, Fluorescence; Tryptophan | 1989 |
Site-directed mutagenesis of beta-adrenergic receptors. Identification of conserved cysteine residues that independently affect ligand binding and receptor activation.
Topics: Amino Acid Sequence; Animals; Cloning, Molecular; Cysteine; Extracellular Space; GTP-Binding Proteins; Humans; L Cells; Membrane Proteins; Mice; Molecular Sequence Data; Mutation; Receptors, Adrenergic, beta; Serine; Signal Transduction | 1989 |
Cystein 402 of HIV gp 120 is essential for CD4-binding and resistance of gp 120 to intracellular degradation.
Topics: Amino Acid Sequence; CD4 Antigens; Cloning, Molecular; Cysteine; DNA, Viral; Electrophoresis, Polyacrylamide Gel; Gene Products, env; HIV Envelope Protein gp120; HIV Envelope Protein gp160; Molecular Sequence Data; Mutation; Precipitin Tests; Protein Precursors; Receptors, HIV; Serine | 1989 |
Stabilizing basic fibroblast growth factor using protein engineering.
Topics: Base Sequence; Chromatography, Affinity; Cloning, Molecular; Cysteine; DNA Restriction Enzymes; Drug Stability; Escherichia coli; Fibroblast Growth Factors; Genetic Engineering; Heparin; Humans; Mutation; Plasmids; Serine | 1988 |
Avian retrovirus pp32 DNA endonuclease is phosphorylated on Ser in the carboxyl-terminal region.
Topics: Amino Acid Sequence; Avian Sarcoma Viruses; Cyanogen Bromide; Cysteine; Deoxyribonuclease I; DNA-Directed DNA Polymerase; Hydroxylamine; Hydroxylamines; Peptide Fragments; Peptide Hydrolases; Phosphorylation; Phosphoserine; Serine; Trypsin | 1988 |
Stimulation of intralysosomal proteolysis by cysteinyl-glycine, a product of the action of gamma-glutamyl transpeptidase on glutathione.
Topics: Animals; Borates; Cysteine; Dipeptides; Enzyme Activation; gamma-Glutamyltransferase; Glutathione; Isoxazoles; Kidney; Liver; Lysosomes; Mice; Peptide Hydrolases; Rats; Serine | 1985 |
Serine incorporation into the selenocysteine moiety of glutathione peroxidase.
Topics: Amino Acids; Animals; Carbon Radioisotopes; Cysteine; Glutathione Peroxidase; Liver; Male; Radioisotopes; Rats; Selenium; Selenocysteine; Serine; Tritium | 1987 |
Gene for a novel tRNA species that accepts L-serine and cotranslationally inserts selenocysteine.
Topics: Base Sequence; Cloning, Molecular; Cysteine; Escherichia coli; Genes, Bacterial; Molecular Sequence Data; Nucleic Acid Conformation; Plasmids; Protein Biosynthesis; RNA, Transfer; Selenium; Selenocysteine; Serine | 1988 |
The conversion of phosphoserine residues to selenocysteine residues on an opal suppressor tRNA and casein.
Topics: Animals; Base Sequence; Caseins; Cattle; Codon; Cysteine; Glutathione Peroxidase; Liver; Phosphoserine; Protein Processing, Post-Translational; RNA, Messenger; RNA, Transfer; Selenium; Selenocysteine; Serine | 1988 |
Selenocysteine on glutathione peroxidase may be converted from phosphoserine on the apo-enzyme synthesized with an opal suppressor phosphoseryl-tRNA.
Topics: Animals; Apoenzymes; Apoproteins; Binding Sites; Cattle; Cysteine; Genes; Glutathione Peroxidase; Liver; Phosphoserine; Protein Biosynthesis; Protein Processing, Post-Translational; RNA, Transfer, Amino Acyl; Selenium; Selenocysteine; Serine; Suppression, Genetic | 1988 |
In vitro metabolism of [3H]-peptide leukotrienes in human and ferret lung: a comparison with the guinea pig.
Topics: Animals; Borates; Carnivora; Cysteine; Ferrets; Guinea Pigs; Humans; Kinetics; Leukotriene E4; Lung; Serine; Species Specificity; SRS-A | 1985 |
Studies of the radical species in compound ES of cytochrome c peroxidase altered by site-directed mutagenesis.
Topics: Amino Acid Sequence; Base Sequence; Cloning, Molecular; Cysteine; Cytochrome-c Peroxidase; Electron Spin Resonance Spectroscopy; Free Radicals; Genes, Fungal; Kinetics; Methionine; Mutation; Peroxidases; Saccharomyces cerevisiae; Serine; Structure-Activity Relationship | 1986 |
Pharmacological evidence that human intralobar airways do not contain different receptors that mediate contractions to leukotriene C4 and leukotriene D4.
Topics: Arachidonic Acid; Arachidonic Acids; Borates; Chromones; Cysteine; Dose-Response Relationship, Drug; Humans; In Vitro Techniques; Leukotriene E4; Lung; Muscle Contraction; Receptors, Cell Surface; Receptors, Leukotriene; Receptors, Prostaglandin; Regression Analysis; Serine; SRS-A | 1986 |
Analysis of gamma delta resolvase mutants in vitro: evidence for an interaction between serine-10 of resolvase and site I of res.
Topics: Amino Acid Sequence; Binding Sites; Cysteine; DNA Transposable Elements; DNA-Binding Proteins; DNA, Bacterial; Methylation; Nucleotidyltransferases; Recombination, Genetic; Serine; Structure-Activity Relationship; Transposases | 1986 |
The role of individual cysteine residues in the structure and function of the v-sis gene product.
Topics: Antigens, Polyomavirus Transforming; Antigens, Viral, Tumor; Cell Transformation, Viral; Cross Reactions; Cysteine; Genes, Viral; Mutation; Oncogene Proteins, Viral; Oncogenes; Platelet-Derived Growth Factor; Protein Conformation; Protein Processing, Post-Translational; Receptors, Cell Surface; Receptors, Platelet-Derived Growth Factor; Retroviridae; Sarcoma Virus, Woolly Monkey; Serine; Transfection | 1987 |
Site-specific mutagenesis of cysteine 148 to serine in the lac permease of Escherichia coli.
Topics: Cysteine; DNA, Bacterial; Escherichia coli; Escherichia coli Proteins; Ethylmaleimide; Genes; Genes, Bacterial; Kinetics; Membrane Transport Proteins; Molecular Weight; Monosaccharide Transport Proteins; Mutation; Nucleic Acid Heteroduplexes; Nucleic Acid Hybridization; Serine; Species Specificity; Symporters; Thiogalactosides | 1986 |
Aromatic boronic acids as probes of the catalytic site of human plasma lecithin-cholesterol acyltransferase.
Topics: Binding Sites; Boronic Acids; Catalysis; Chromatography; Cysteine; Histidine; Humans; Hydrogen-Ion Concentration; Kinetics; Phenylmethylsulfonyl Fluoride; Phosphatidylcholine-Sterol O-Acyltransferase; Serine | 1987 |
The origin of the sulfur atom of thiamin.
Topics: Carbon Radioisotopes; Cysteine; Cystine; Escherichia coli; Methionine; Saccharomyces cerevisiae; Serine; Sulfur Radioisotopes; Thiamine | 1987 |
A new method for the selective isolation of phosphoserine-containing peptides.
Topics: Cysteine; Peptides; Phosphorylation; Phosphoserine; Serine | 1987 |
Neutral amino acid transport in mouse peritoneal macrophages.
Topics: Alanine; Amino Acids; Animals; Biological Transport; Cells, Cultured; Cysteine; Kinetics; Leucine; Macrophages; Male; Mice; Mice, Inbred C57BL; Serine; Tritium | 1987 |
Evidence for an alanine, serine, and cysteine system of transport in isolated brain capillaries.
Topics: Alanine; Animals; Biological Transport; Capillaries; Cerebrovascular Circulation; Cysteine; Female; In Vitro Techniques; Male; Rats; Rats, Inbred Strains; Serine; Sodium | 1987 |
Quantitative determination of phosphoserine by high-performance liquid chromatography as the phenylthiocarbamyl-S-ethylcysteine. Application to picomolar amounts of peptides and proteins.
Topics: Amino Acids; Animals; Cattle; Chromatography, High Pressure Liquid; Cysteine; Indicators and Reagents; Oligopeptides; Peptides; Phosphorylation; Phosphoserine; Proteins; Serine; Troponin | 1987 |
Reversible dissociation of active octamer of cyanase to inactive dimer promoted by alteration of the sulfhydryl group.
Topics: Aminohydrolases; Azides; Bicarbonates; Carbon-Nitrogen Lyases; Chromatography, Gel; Cysteine; Enzyme Activation; Enzyme Reactivators; Escherichia coli; Ethylmaleimide; Macromolecular Substances; Mercuric Chloride; Methyl Methanesulfonate; Mutation; Oxalates; Oxalic Acid; Serine; Spectrometry, Fluorescence; Structure-Activity Relationship; Sulfhydryl Compounds; Tetranitromethane | 1988 |
Glucose permease of Escherichia coli. The effect of cysteine to serine mutations on the function, stability, and regulation of transport and phosphorylation.
Topics: Amino Acid Sequence; Biological Transport, Active; Cysteine; Enzyme Stability; Escherichia coli; Kinetics; Molecular Sequence Data; Mutation; Phosphoenolpyruvate Sugar Phosphotransferase System; Phosphorylation; Serine | 1988 |
Physiological comparison of D-cysteine desulfhydrase of Escherichia coli with 3-chloro-D-alanine dehydrochlorinase of Pseudomonas putida CR 1-1.
Topics: beta-Alanine; Cystathionine gamma-Lyase; Cysteine; Cytosol; Escherichia coli; Lyases; Pseudomonas; Serine | 1988 |
The molecular evolution of genes and proteins: a tale of two serines.
Topics: Amino Acid Sequence; Binding Sites; Biological Evolution; Codon; Cysteine; Enzymes; Esterases; Exons; Molecular Sequence Data; Mutation; Peptide Hydrolases; Serine; Threonine | 1988 |
Cardiac troponin I, isolated from bovine heart, contains two adjacent phosphoserines. A first example of phosphoserine determination by derivatization to S-ethylcysteine.
Topics: Amino Acid Sequence; Animals; Cattle; Chromatography, High Pressure Liquid; Cysteine; Endopeptidases; Metalloendopeptidases; Molecular Sequence Data; Myocardium; Peptide Fragments; Phosphates; Phosphorylation; Phosphoserine; Serine; Troponin; Trypsin | 1988 |
Some characteristics of threonine transport across the blood-brain barrier of the rat.
Topics: Amino Acids; Amino Acids, Cyclic; Aminoisobutyric Acids; Animals; Binding, Competitive; Biological Transport; Blood-Brain Barrier; Brain; Cysteine; Leucine; Male; Phenylalanine; Rats; Rats, Inbred Strains; Serine; Sodium; Threonine | 1988 |
Production, biological activity, and structure of recombinant basic fibroblast growth factor and an analog with cysteine replaced by serine.
Topics: Amino Acid Sequence; Animals; Base Sequence; Cattle; Cell Division; Cells, Cultured; Cloning, Molecular; Cysteine; Fibroblast Growth Factors; Genes; Genes, Synthetic; Humans; Mice; Molecular Sequence Data; Recombinant Proteins; Serine | 1988 |
Influence of natural and recombinant interleukin 2 on endothelial cell arachidonate metabolism. Induction of de novo synthesis of prostaglandin H synthase.
Topics: 6-Ketoprostaglandin F1 alpha; Alanine; Arachidonic Acid; Arachidonic Acids; Blotting, Western; Chromatography, High Pressure Liquid; Cycloheximide; Cysteine; Dactinomycin; Endothelium, Vascular; Enzyme Induction; Epoprostenol; Humans; Interleukin-2; Molecular Weight; Prostaglandin-Endoperoxide Synthases; Recombinant Proteins; Serine; Structure-Activity Relationship; Tissue Plasminogen Activator; von Willebrand Factor | 1988 |
Properties of a mutant lactose carrier of Escherichia coli with a Cys148----Ser148 substitution.
Topics: Amino Acid Sequence; Biological Transport, Active; Cloning, Molecular; Codon; Cysteine; Escherichia coli; Escherichia coli Proteins; Galactosides; Genes, Bacterial; Membrane Transport Modulators; Membrane Transport Proteins; Monosaccharide Transport Proteins; Mutation; Serine; Structure-Activity Relationship; Sulfhydryl Reagents; Symporters | 1985 |
Metabolism of sulfur-containing amino acids in the dermatophyte Microsporum gypseum. II. Acidic amino acid derivatives.
Topics: Amino Acids, Sulfur; Arginine; Culture Media; Cysteic Acid; Cysteine; Glucose; Microsporum; Neurotransmitter Agents; Serine; Sulfates; Sulfites; Taurine | 1985 |
Rat liver L-threonine deaminase: properties and purification.
Topics: Animals; Chromatography, Gel; Cysteine; Hydrogen-Ion Concentration; Liver; Male; Molecular Weight; Protein Conformation; Rats; Rats, Inbred Strains; Serine; Substrate Specificity; Threonine; Threonine Dehydratase | 1985 |
Isolation and characterization of the ram spermatidal nuclear proteins P1, 3 and T.
Topics: Amino Acids; Animals; Arginine; Cell Nucleus; Cysteine; DNA; High Mobility Group Proteins; Histidine; Male; Nucleoproteins; Phosphoproteins; Phosphorylation; Serine; Sheep; Sodium Chloride; Spermatids | 1985 |
Activation of sodium cyanide to a toxic but non-mutagenic metabolite in Salmonella typhimurium.
Topics: Biotransformation; Cyanides; Cysteine; Cysteine Synthase; Mutation; Salmonella typhimurium; Serine | 1985 |
Homocystinuria due to cystathionine beta-synthase deficiency--the effects of betaine treatment in pyridoxine-responsive patients.
Topics: Adolescent; Adult; Betaine; Child; Cystathionine beta-Synthase; Cysteine; Drug Therapy, Combination; Female; Folic Acid; Homocysteine; Homocystinuria; Humans; Hydro-Lyases; Male; Methionine; Middle Aged; Pyridoxine; Serine | 1985 |
Incorporation of radiolabelled amino acids into the sulphur-containing metabolites of paracetamol by the hamster.
Topics: Acetaminophen; Amino Acids; Animals; Chromatography, High Pressure Liquid; Chromatography, Thin Layer; Cricetinae; Cysteine; Male; Mesocricetus; Methionine; Serine | 1985 |
A new Na+-independent transport system for dipolar amino acids apparently corresponding to systems persisting after erythrocyte maturation in some mammalian genotypes.
Topics: Alanine; Amino Acids; Animals; Biological Transport, Active; Columbidae; Cysteine; Erythrocyte Aging; Erythrocytes; Horses; Kinetics; Serine; Sheep; Sodium; Species Specificity; Threonine | 1985 |
[Possibilities of prevention of the oxidative inactivation of alpha 1-antiproteinase].
Topics: alpha 1-Antitrypsin; Ascorbic Acid; Chloramines; Cysteine; Enzyme Reactivators; Humans; In Vitro Techniques; Methionine; Oxidation-Reduction; Serine; Tosyl Compounds | 1985 |
Significance of the glycine cleavage system in glycine and serine catabolism in avian liver.
Topics: Ammonium Chloride; Animals; Arylformamidase; Bicarbonates; Carbon Dioxide; Carbon Isotopes; Chickens; Columbidae; Cycloserine; Cysteine; Enzyme Activation; Folic Acid; Glycine; Hydroxylamines; Hypoxanthines; L-Serine Dehydratase; Liver; Male; Mitochondria, Liver; NAD; NADP; Oxidoreductases; Pyridoxal Phosphate; Rats; Rats, Inbred Strains; Semicarbazides; Serine; Species Specificity; Subcellular Fractions; Transferases; Uric Acid | 1971 |
[Biochemical aspects of the effect of L-dopa in patients with Parkinson's disease].
Topics: Cysteine; Cystine; Dihydroxyphenylalanine; Female; Glycine; Humans; Male; Methionine; Parkinson Disease; Serine; Threonine; Time Factors | 1972 |
Redistribution of pyridoxal phosphate in the male rat liver as a result of repeated injections of hydrocortisone.
Topics: Alanine Transaminase; Animals; Aspartic Acid; Carboxy-Lyases; Cystathionine; Cysteine; Dose-Response Relationship, Drug; Homocysteine; Homoserine; Hydro-Lyases; Hydrocortisone; L-Serine Dehydratase; Liver; Lyases; Male; Pyridoxal Phosphate; Rats; Seasons; Serine; Time Factors; Tyrosine Transaminase | 1973 |
The position of various cleavages of rabbit immunoglobulin G.
Topics: Amino Acid Sequence; Amino Acids; Animals; Aspartic Acid; Bromine; Carboxypeptidases; Chemical Phenomena; Chemistry; Chromatography, Gel; Cyanides; Cysteine; gamma-Globulins; Glutamates; Leucine; Lysine; Pepsin A; Proline; Rabbits; Serine; Sulfhydryl Compounds; Threonine; Trypsin | 1968 |
Activity of the hypothalamo-neurohypophysial complex of the European eel (Anguilla anguilla L.) assessed by the use of an in situ staining technique and by autoradiography.
Topics: Adaptation, Physiological; Animals; Autoradiography; Cysteine; Eels; Electric Stimulation; Hypothalamo-Hypophyseal System; Neurosecretion; Seawater; Serine; Sodium Chloride; Staining and Labeling; Stress, Physiological; Sulfur Isotopes | 1969 |
The amino acid sequence of Streptomyces griseus trypsin. I. The peptic peptides.
Topics: Amides; Amino Acid Sequence; Amino Acids; Autoanalysis; Chromatography, Ion Exchange; Cysteine; Dansyl Compounds; Electrophoresis, Paper; Hydrogen-Ion Concentration; Pepsin A; Peptide Hydrolases; Peptides; Pronase; Serine; Streptomyces; Streptomyces griseus; Thiocyanates; Trypsin | 1973 |
Characterization of phycocyanin from Chromonas species.
Topics: Amino Acids; Ammonium Sulfate; Bile Pigments; Chromatography, Gel; Circular Dichroism; Cyanobacteria; Cysteine; Electrophoresis, Polyacrylamide Gel; Eukaryota; Lysine; Macromolecular Substances; Mathematics; Peptides; Plant Proteins; Rhodophyta; Serine; Sodium Dodecyl Sulfate; Species Specificity; Spectrometry, Fluorescence; Spectrophotometry; Spectrophotometry, Ultraviolet; Ultracentrifugation | 1973 |
The structural gene for O-acetylserine sulfhydrylase A in Salmonella typhimurium. Identity with the trzA locus.
Topics: Acridines; Chromosome Mapping; Cross Reactions; Cysteine; Drug Resistance, Microbial; Genes; Genotype; Immunodiffusion; Lyases; Mutation; Nitrosoguanidines; Phosphotransferases; Salmonella typhimurium; Serine; Transduction, Genetic; Triazoles | 1974 |
Further syntheses in the study of structure-activity relationships of neuropharmacologically active amino acids.
Topics: Amino Alcohols; Animals; Aspartic Acid; Cats; Central Nervous System; Choline; Cysteine; Homocysteine; Muscle Spindles; Neurons; Serine; Sulfinic Acids | 1965 |
[Effect of different thiols on renal excretion of water and osmotically active substances in the rabbit].
Topics: Absorption; Alanine; Animals; beta-Aminoethyl Isothiourea; Cysteine; Dimercaprol; Kidney Concentrating Ability; Kidney Tubules; Osmolar Concentration; Penicillamine; Rabbits; Serine; Urine | 1968 |
[Effect of mercaptans on urine volume and osmolarity in rabbits].
Topics: Alanine; Animals; beta-Aminoethyl Isothiourea; Cysteine; Dimercaprol; Female; Kidney; Osmolar Concentration; Penicillamine; Rabbits; Receptors, Drug; Serine; Sodium Chloride; Thiosulfates; Urine; Vasopressins | 1969 |
[Effect of Ni2+ ions on dephosphorylation of ATP and formation of aminoacyl phosphates by enzymes of rat liver microsomes in the presence of amino acids].
Topics: Adenosine Triphosphatases; Adenosine Triphosphate; Amino Acids; Animals; Aspartic Acid; Chlorides; Cysteine; Depression, Chemical; In Vitro Techniques; Membranes; Microsomes, Liver; Nickel; Phosphoric Acids; Rats; Serine; Stimulation, Chemical | 1969 |
Biosynthesis of the peptidoglycan of bacterial cell walls. 18. Purification and properties of L-alanyl transfer ribonucleic acid-uridine diphosphate-N-acetylmuramyl-pentapeptide transferase from Lactobacillus viridescens.
Topics: Alanine; Carbon Isotopes; Cell Wall; Chemical Phenomena; Chemistry; Chromatography, DEAE-Cellulose; Chromatography, Gel; Chromatography, Paper; Chromatography, Thin Layer; Cysteine; Electrophoresis; Electrophoresis, Disc; Glycine; Glycosaminoglycans; Hydrogen-Ion Concentration; Lactobacillus; Molecular Weight; Nickel; Oxidation-Reduction; RNA, Transfer; Serine; Transferases; Uracil Nucleotides | 1970 |
[Behavior of Shigella flexneri F6S and certain of its mutants in synthetic medium].
Topics: Amino Acids; Culture Media; Cysteine; Cystine; Folic Acid; Genetics, Microbial; Growth Substances; Methionine; Mutation; Niacinamide; Serine; Shigella; Temperature; Thiamine; Vitamin B 12 | 1971 |
Micromethod for the quantitative determination of L-alanine.
Topics: Alanine; Aminobutyrates; Cysteine; Isoleucine; Kinetics; Microchemistry; NAD; Serine; Spectrum Analysis; Valine | 1965 |
Serine biosynthesis in rat liver. Regulation of enzyme concentration by dietary factors.
Topics: Alcohol Oxidoreductases; Animals; Caseins; Cycloheximide; Cysteine; Dactinomycin; Dietary Proteins; Feedback; Glycerolphosphate Dehydrogenase; Glycine; Hydro-Lyases; In Vitro Techniques; Kinetics; Liver; Phosphoric Monoester Hydrolases; Rats; Serine | 1966 |
Cystathioninuria.
Topics: Adult; Amino Acid Metabolism, Inborn Errors; Amino Acids; Carcinoma, Hepatocellular; Child, Preschool; Cysteine; Diet Therapy; Female; Galactosemias; Glycogen; Humans; Infant; Intellectual Disability; Liver Neoplasms; Male; Maple Syrup Urine Disease; Methionine; Middle Aged; Neuroblastoma; Phenylketonurias; Portal Vein; Pyridoxine; Serine; Sulfisoxazole; Tyrosine | 1967 |
On the possible involvement of charge transfer complexes (redox systems) in radioprotection.
Topics: Copper; Cysteine; Electron Spin Resonance Spectroscopy; Energy Transfer; Glutathione; Glycine; Oxidation-Reduction; Radiation Protection; Serine; Spectrum Analysis; Valine | 1967 |
Effect of protein intake on tissue amino acid levels and the enzymes of serine biosynthesis in the rat.
Topics: Alcohol Oxidoreductases; Amino Acids; Animals; Autoanalysis; Brain; Caseins; Cysteine; Cystine; Dietary Proteins; Glycine; Hydro-Lyases; Kidney; L-Serine Dehydratase; Liver; Male; Methionine; Phosphoric Monoester Hydrolases; Protein Deficiency; Rats; Serine; Taurine | 1968 |
Regulatory phenomena in mammalian serine metabolism.
Topics: Alcohol Oxidoreductases; Animals; Cortisone; Cycloheximide; Cysteine; Dactinomycin; Dietary Proteins; Glycerophosphates; Hydro-Lyases; Liver; Phosphoric Monoester Hydrolases; Rats; Serine | 1967 |
Cyanide metabolism in higher plants. 3. The biosynthesis of beta-cyanolanine.
Topics: Alanine; Amino Acids; Asparagine; Carbon Isotopes; Colorimetry; Cyanides; Cysteine; Hydro-Lyases; Hydrogen Cyanide; Plants; Serine; Stimulation, Chemical | 1968 |
Regulatory significance of transfer RNA charging levels. I. Measurements of charging levels in livers of chow-fed rats, fasting rats, and rats fed balanced or imbalanced mixtures of amino acids.
Topics: Amino Acids; Animals; Cysteine; Diet; Fasting; Ligases; Liver; Male; Periodic Acid; Rats; RNA, Transfer; Serine; Threonine; Tryptophan | 1969 |
Characterization of porcine malate dehydrogenase. I. An active center peptide.
Topics: Acetamides; Amino Acid Sequence; Animals; Binding Sites; Carbon Isotopes; Carboxypeptidases; Chromatography, Ion Exchange; Chromatography, Thin Layer; Cysteine; Dansyl Compounds; Glycine; Histidine; Iodoacetates; Kinetics; Malate Dehydrogenase; Methionine; Mitochondria, Muscle; Myocardium; NAD; Peptides; Pronase; Serine; Swine; Threonine | 1971 |
Alterations of free amino acids concentrations in cat brain induced by rapid eye movement sleep deprivation.
Topics: Amino Acids; Aminobutyrates; Animals; Arginine; Aspartic Acid; Brain; Cats; Caudate Nucleus; Cysteine; Frontal Lobe; Glutamates; Glycine; Hippocampus; Histidine; Lysine; Male; Occipital Lobe; Reticular Formation; Serine; Sleep Deprivation; Sleep, REM; Thalamus; Threonine; Tyrosine | 1971 |
Enzymatic phosphorylation of serine.
Topics: Adenosine Triphosphate; Ammonium Sulfate; Carbon Isotopes; Chromatography, DEAE-Cellulose; Chromatography, Gel; Cobalt; Cysteine; Diphosphates; Drug Stability; Homoserine; Hydrogen-Ion Concentration; Kinetics; Magnesium; Phosphotransferases; Propionibacterium; Protamines; Serine; Species Specificity; Stereoisomerism; Structure-Activity Relationship; Temperature; Thermodynamics; Threonine | 1972 |
Radical yield in X-irradiated biological molecules. II. Naturally-occurring amino-acids.
Topics: Alanine; Amino Acids; Arginine; Asparagine; Aspartic Acid; Cysteine; Cystine; Electron Spin Resonance Spectroscopy; Free Radicals; Glutamates; Histamine; Isoleucine; Leucine; Lysine; Methionine; Phenylalanine; Proline; Radiation Effects; Serine; Threonine; Tryptophan; Tyrosine; Valine | 1974 |
Biosynthesis of sphingolipid bases. II. Keto intermediates in synthesis of sphingosine and dihydrosphingosine by cell-free extracts of Hansenula ciferri.
Topics: Amino Alcohols; Ascomycota; Autoradiography; Carbon Isotopes; Cell-Free System; Chemical Phenomena; Chemistry; Chromatography, Thin Layer; Coenzyme A; Crystallization; Cysteine; Ketones; Models, Biological; NADP; Palmitic Acids; Serine; Stimulation, Chemical | 1968 |
Regulation of aspartate family amino acid biosynthesis in Brevibacterium flavum. I. Inhibition by amino acids of the enzymes in threonine biosynthesis.
Topics: Alanine; Alcohol Oxidoreductases; Amino Acids; Aspartate-Semialdehyde Dehydrogenase; Aspartic Acid; Brevibacterium; Cysteine; Glutathione; Isoleucine; Lyases; Lysine; Methionine; Phosphotransferases; Serine; Temperature; Threonine | 1968 |
Studies on the catalytic and regulatory properties of homoserine dehydrogenase of Zea mays roots.
Topics: Alcohol Oxidoreductases; Aminobutyrates; Aspartic Acid; Binding Sites; Cysteine; Hydroxybutyrates; Kinetics; NAD; NADP; Plants; Serine; Zea mays | 1969 |
Convulsant activity of homocysteine and other short-chain mercaptoacids: protection therefrom.
Topics: Animals; Betaine; Central Nervous System Stimulants; Cysteine; Glycine; Homocysteine; Male; Methionine; Phenobarbital; Pyridoxine; Rats; Serine | 1969 |
Absorption of some amino acids by the haemoflagellate, Trypanosoma gambiense.
Topics: Alanine; Amino Acids; Animals; Arginine; Aspartic Acid; Biological Transport; Carbon Isotopes; Cysteine; Glutamates; Glycine; Iodoacetates; Kinetics; Leucine; Lysine; Ornithine; Rats; Serine; Threonine; Trypanosoma brucei gambiense | 1972 |
Kinetic properties of pyruvate kinases from turtle liver and heart.
Topics: Alanine; Allosteric Regulation; Animals; Binding Sites; Citrates; Cysteine; Enzyme Activation; Fructosephosphates; Hexosediphosphates; Hydrogen-Ion Concentration; Isoleucine; Ketoglutaric Acids; Kinetics; Liver; Magnesium; Methionine; Myocardium; Organ Specificity; Phenylalanine; Phosphoenolpyruvate; Protein Binding; Pyruvate Kinase; Serine; Succinates; Tryptophan; Turtles; Valine | 1974 |
An investigation of the effects of L-methionine and related metabolites on rat behavior.
Topics: Animals; Avoidance Learning; Behavior, Animal; Betaine; Conditioning, Operant; Cysteine; Male; Methionine; Rats; Serine | 1974 |
L-phenylalanine interactions with structurally related substances at the intestinal mucosa.
Topics: Alanine; Amino Acids; Animals; Binding Sites; Binding, Competitive; Biological Transport; Carbon Radioisotopes; Cysteine; Dihydroxyphenylalanine; Female; Intestinal Mucosa; Intestine, Small; Jejunum; Kinetics; Phenylalanine; Rats; Receptors, Drug; Serine; Time Factors | 1974 |
Navy (Haricot)-bean (Phaseolus vulgaris) lectin. Isolation and characterization of tow components from a toxic agglutinating extract.
Topics: Alanine; Animals; Aspartic Acid; Chromatography, DEAE-Cellulose; Chromatography, Gel; Cysteine; Electrophoresis, Polyacrylamide Gel; Erythrocytes; Glucosamine; Glycoproteins; Hemagglutination Tests; Horses; Lectins; Leucine; Leukocytes; Mannose; Methionine; Molecular Weight; Plant Lectins; Plants; Quail; Serine; Tryptophan | 1974 |
Atypical pattern of utilization of amino acids for mitochondrial protein synthesis in HeLa cells.
Topics: Amino Acids; Arginine; Chloramphenicol; Cycloheximide; Cysteine; Cystine; Electrophoresis, Polyacrylamide Gel; Emetine; Endoplasmic Reticulum; Female; Glutamine; HeLa Cells; Humans; Leucine; Lysine; Methionine; Mitochondria; Neoplasm Proteins; Phenylalanine; Polyribosomes; Serine; Threonine; Tritium; Tryptophan | 1973 |
The role of amino acids as stimulants of antral release.
Topics: Acetylcholine; Alanine; Amino Acids; Animals; Choline; Cysteine; Dogs; Female; Gastric Fistula; Gastric Juice; Glycine; Histamine; Male; Pentagastrin; Phenylalanine; Pyloric Antrum; Secretory Rate; Serine; Stimulation, Chemical | 1974 |
Biosynthesis of 4-thiouridylate. Participation of a sulfurtransferase containing pyridoxal 5'-phosphate.
Topics: Alanine; Aldehydes; Borohydrides; Chromatography; Cysteine; Enzyme Activation; Escherichia coli; Hydroxyapatites; Hydroxylamines; Kinetics; Organophosphorus Compounds; Picolines; Pyridoxal Phosphate; Pyruvates; RNA, Transfer; Serine; Sulfhydryl Compounds; Sulfur Isotopes; Sulfurtransferases; Thiouridine; Uridine | 1972 |
Characterization of colicin Ia and colicin Ib. Chemical studies of protein structure.
Topics: Acrylamides; Amino Acid Sequence; Amino Acids; Arginine; Autoradiography; Chemical Phenomena; Chemistry; Colicins; Cysteine; Electrophoresis; Electrophoresis, Paper; Escherichia coli; Hydrogen-Ion Concentration; Iodine; Iodine Isotopes; Isoelectric Focusing; Molecular Weight; Peptides; Serine; Sodium Dodecyl Sulfate; Trypsin | 1972 |
Kinetic spectroscopic studies of substrate and subunit interactions of tryptophan synthetase.
Topics: Alcohols; Catalysis; Cysteine; Deamination; Escherichia coli; Hydro-Lyases; Kinetics; Macromolecular Substances; Mercaptoethanol; Pyridoxal Phosphate; Quaternary Ammonium Compounds; Serine; Spectrometry, Fluorescence; Spectrophotometry; Tryptophan Synthase | 1972 |
The effect of triazole on cysteine biosynthesis in Salmonella typhimurium.
Topics: Acetyltransferases; Culture Media; Cysteine; Genes; Membrane Transport Proteins; Methionine; Mutation; Salmonella typhimurium; Serine; Sulfides; Sulfites; Transduction, Genetic; Triazoles | 1972 |
Recognition of nonsense codons in mammalian cells.
Topics: Acylation; Adenine Nucleotides; Amino Acyl-tRNA Synthetases; Animals; Arginine; Cattle; Cysteine; Escherichia coli; Genetic Code; Guanine Nucleotides; Liver; Oligonucleotides; Protein Binding; Ribosomes; RNA, Transfer; Serine; Suppression, Genetic; Tritium; Tryptophan; Uracil Nucleotides | 1972 |
An Aspergillus nidulans mutant lacking cystathionine -synthase: identity of L-serine sulfhydrylase with cystathionine -synthase and its distinctness from O-acetyl-L-serine sulfhydrylase.
Topics: Aspergillus; Aspergillus nidulans; Carbon Isotopes; Cell-Free System; Culture Media; Cystathionine; Cysteine; Homocysteine; Hydro-Lyases; Molecular Weight; Mutation; Selenium; Serine; Species Specificity | 1973 |
Seryl transfer ribonucleic acid synthetase from Escherichia coli. Substrate binding and chemical modification of cysteinyl residues.
Topics: Adenosine Triphosphate; Alkylation; Amides; Amino Acids; Amino Acyl-tRNA Synthetases; Benzoates; Binding Sites; Carbon Isotopes; Chemical Phenomena; Chemistry; Chromatography, Affinity; Cysteine; Disulfides; Escherichia coli; Iodoacetates; Isoelectric Focusing; Mercuribenzoates; Phosphorus Isotopes; Protein Binding; Serine; Structure-Activity Relationship; Sulfhydryl Compounds; Urea | 1973 |
The cysteine desulfhydrase of Salmonella typhimurium. Kinetic and catalytic properties.
Topics: Binding Sites; Cell-Free System; Centrifugation, Density Gradient; Chromatography, Gel; Cystathionine; Cysteine; Drug Stability; Enzyme Activation; Enzyme Induction; Homocysteine; Hot Temperature; Hydrogen-Ion Concentration; Kinetics; Lyases; Mathematics; Mercaptoethanol; Methionine; Mutation; Salmonella typhimurium; Serine; Stereoisomerism; Structure-Activity Relationship; Sulfhydryl Compounds | 1973 |
Effect of adenosine on methionyl-tRNA synthetase.
Topics: Adenosine; Adenosine Triphosphate; Amino Acyl-tRNA Synthetases; Binding Sites; Cysteine; Escherichia coli; Isoleucine; Kinetics; Magnesium; Methionine; Phenylalanine; Phosphates; Serine; Trypsin; Valine | 1973 |
Modification of transfer ribonucleic acid by an alkylating fragment from S-(1,2-dichlorovinyl)-L-cysteine.
Topics: Amino Acids; Amino Acyl-tRNA Synthetases; Animals; Binding Sites; Carbon Radioisotopes; Chromatography, Gel; Cysteine; Escherichia coli; Histidine; Liver; Ribosomes; RNA, Bacterial; RNA, Messenger; RNA, Transfer; Serine; Species Specificity; Spectrophotometry, Ultraviolet; Sulfur Radioisotopes; Transfer RNA Aminoacylation; Tyrosine; Vinyl Compounds | 1974 |
Synthesis of S-substituted cysteine derivatives by the cysteine synthase (O-acetylserine sulfhydrylase) of onion (Allium cepa) and Escherichia coli.
Topics: Carbon Radioisotopes; Cysteine; Escherichia coli; Plants; Serine | 1974 |
Evidence for the identity of O-acetylserine sulfhydrylase with O-acetylhomoserine sulfhydrylase in yeast.
Topics: Ammonium Sulfate; Chromatography, DEAE-Cellulose; Chromatography, Gel; Cysteine; Electrophoresis, Disc; Electrophoresis, Paper; Electrophoresis, Polyacrylamide Gel; Homoserine; Hydrogen Sulfide; Hydrogen-Ion Concentration; Lyases; Meat; Mutation; Protein Biosynthesis; Saccharomyces cerevisiae; Serine | 1974 |
Whale immunoglobulins. I. Light chain types.
Topics: Amino Acids; Animals; Autoanalysis; Cetacea; Chromatography, DEAE-Cellulose; Cysteine; Electrophoresis, Paper; Humans; Hydrazines; Immunoglobulin Fragments; Immunoglobulin G; Molecular Weight; Peptide Termination Factors; Peptides; Serine | 1972 |
Enhancement of iron absorption from ligated segments of rat intestine by histidine, cysteine, and lysine: effects of removing ionizing groups and of stereoisomerism.
Topics: Alanine; Amino Acids; Animals; Biological Transport, Active; Chelating Agents; Chemical Phenomena; Chemistry; Cysteine; Deamination; Decarboxylation; Duodenum; Histidine; Intestine, Small; Ions; Iron; Iron Isotopes; Ligation; Lysine; Male; Rats; Serine; Stereoisomerism; Structure-Activity Relationship; Sulfhydryl Compounds | 1973 |
Catalytic studies on tryptophanase from Bacillus alvei.
Topics: Bacillus; Cysteine; Hydro-Lyases; Indoles; Kinetics; L-Serine Dehydratase; Pyruvates; Serine; Spectrophotometry; Tryptophan; Tryptophan Synthase; Tryptophanase | 1973 |
The use of a sulfide ion selective electrode to study O-acetylserine sulfhydrylase from germinating rapeseed.
Topics: Chromatography, Gel; Chromatography, Paper; Chromatography, Thin Layer; Cysteine; Electrodes; Hydrogen-Ion Concentration; Kinetics; Lyases; Mathematics; Plants; Potentiometry; Serine; Sulfhydryl Compounds; Sulfur; Sulfur Isotopes; Time Factors | 1973 |
The use of the L-serine sulfhydrylase assay for the estimation of cystathionine beta-synthase.
Topics: Aged; Animals; Arteriosclerosis; Colorimetry; Cystathionine; Cysteine; Evaluation Studies as Topic; Female; Humans; Hydro-Lyases; Hydrogen-Ion Concentration; Kinetics; L-Serine Dehydratase; Liver; Male; Methods; Middle Aged; Rats; Serine; Thromboembolism; Time Factors | 1973 |
The synthesis of taurine from sulfate. V. Regulatory modifiers of the chick liver enzyme system.
Topics: Adenosine Monophosphate; Alanine; Allosteric Regulation; Animals; Chickens; Cysteine; Ethionine; Homocysteine; Liver; Methionine; Organophosphorus Compounds; S-Adenosylmethionine; Serine; Sulfinic Acids; Sulfonic Acids; Sulfur Radioisotopes; Sulfuric Acids; Sulfurtransferases; Taurine | 1973 |
Further studies on anthranilate N-acetyltransferase and the metabolism of N-acetylanthranilic acid in Aerobacter aerogenes.
Topics: Acetylation; Acetyltransferases; Aminobenzoates; Aniline Compounds; Carbon Radioisotopes; Chromatography, Ion Exchange; Cysteine; Enterobacter; Galactose; Glucosamine; Glucosephosphates; Glycosides; Kinetics; Mutation; ortho-Aminobenzoates; Salicylates; Serine; Spectrophotometry; Spectrophotometry, Ultraviolet; Tritium | 1973 |
Two more examples of Hb Porto Alegre, alpha-2 beta-2 9 Ser leads to Cys in Belém, Brazil.
Topics: Brazil; Chromatography, DEAE-Cellulose; Chromatography, Gel; Cysteine; Electrophoresis, Paper; Hemoglobins, Abnormal; Humans; Male; Middle Aged; Serine | 1973 |
Sulfate reduction in a cell-free system of Chlorella. The ferredoxin dependent reduction of a protein-bound intermediate by a thiosulfonate reductase.
Topics: Cell-Free System; Chlorella; Chromatography, DEAE-Cellulose; Cysteine; Ferredoxins; Glutathione; Molecular Weight; Oxidation-Reduction; Oxidoreductases; Protein Binding; Proteins; Serine; Spectrophotometry; Sulfides; Sulfites; Sulfonic Acids; Sulfur Radioisotopes; Sulfuric Acids | 1973 |
The protective effect of thiosulfate upon the inactivation of aspartate aminotransferase by aminoacrylic-acid-producing substrates.
Topics: Acrylates; Aspartate Aminotransferases; Cysteine; Enzyme Activation; Glutarates; Serine; Sulfinic Acids; Thiosulfates | 1973 |
Action of liver glutamine transaminase and L-amino acid oxidase on several glutamine analogs. Preparation and properties of the 4-S, O, and NH analogs of alpha-ketoglutaramic acid.
Topics: Amidohydrolases; Amino Acid Oxidoreductases; Amino Acids, Diamino; Animals; Carbamates; Carboxylic Acids; Chemical Phenomena; Chemistry; Chromatography, Paper; Cysteine; Glutamine; Glyoxylates; Hydrogen Peroxide; Imidazoles; Lactams; Liver; Propionates; Rats; Semicarbazides; Serine; Snakes; Spectrophotometry, Infrared; Spectrophotometry, Ultraviolet; Thiazoles; Transaminases; Urea; Venoms | 1973 |
Synthesis and catalytic properties of the heptapeptide L-seryl-L-prolyl-L-cysteinyl-L-steryl-alpha-L-glutamyl-L-threonyl-L-tyrosine.
Topics: Acetates; Carboxypeptidases; Chromatography, Gel; Chromatography, Thin Layer; Cysteine; Dicyclohexylcarbodiimide; Esters; Glutamates; Hydrogen-Ion Concentration; Kinetics; Mathematics; Nitrophenols; Oligopeptides; Optical Rotation; Proline; Serine; Spectrophotometry; Spectrophotometry, Ultraviolet; Sulfhydryl Compounds; Threonine; Tyrosine | 1974 |
Functional properties of hemoglobin Pôrto Alegre (alpha2A beta2 9Ser leads to Cys) and the reactivity of its extra cysteinyl residue.
Topics: Amino Acid Sequence; Amino Acids; Binding Sites; Brazil; Carboxyhemoglobin; Chromatography, Gel; Chromatography, Ion Exchange; Cysteine; Disulfides; Hemoglobins, Abnormal; Humans; Hydrogen-Ion Concentration; Kinetics; Macromolecular Substances; Mercuribenzoates; Oxygen; Oxyhemoglobins; Protein Binding; Protein Conformation; Serine | 1974 |
Effect of dietary methionine level on its metabolism in rats.
Topics: Animal Nutritional Physiological Phenomena; Animals; Body Composition; Carbon Dioxide; Carbon Radioisotopes; Cysteine; Deficiency Diseases; Liver; Male; Methionine; Muscles; Oxidation-Reduction; Phospholipids; Protein Biosynthesis; Rats; Serine; Structure-Activity Relationship; Urine | 1974 |
The enzymatic synthesis of L-cysteine in higher plant tissues.
Topics: Acetyl Coenzyme A; Acetyltransferases; Chromatography, Gel; Chromatography, Ion Exchange; Cysteine; Drug Stability; Hydrogen-Ion Concentration; Kinetics; Lyases; Plants; Serine; Species Specificity; Spectrophotometry, Ultraviolet; Structure-Activity Relationship; Sulfur Radioisotopes; Time Factors | 1974 |
Reversal by serine and potentiation by glycine of the inhibitory effect of 1,2,4-triazole on growth of Salmonella typhimurium.
Topics: Adenine; Amino Acids; Cysteine; Drug Resistance, Microbial; Drug Synergism; Glycine; Homocysteine; Methionine; Mutation; Salmonella typhimurium; Serine; Triazoles | 1967 |
Interactions between the subunits of the tryptophan synthetase of Escherichia coli. Optical properties of an intermediate bound to the alpha-2 beta-2 complex.
Topics: Acrylates; Amino Acids; Catalysis; Centrifugation, Density Gradient; Centrifugation, Zonal; Chemical Phenomena; Chemistry, Physical; Cysteine; Escherichia coli; Hydro-Lyases; Mercaptoethanol; Protein Binding; Pyridoxal Phosphate; Serine; Spectrophotometry | 1967 |
Regulation of homoserine biosynthesis by L-cysteine, a terminal metabolite of a linked pathway.
Topics: Alcohol Oxidoreductases; Amino Acids; Cysteine; Escherichia coli; Feedback; Rhodopseudomonas; Rhodospirillum; Serine; Threonine | 1967 |
Genetic and biochemical studies of enzymatically active subunits of E. coli tryptophan synthetase.
Topics: Binding Sites; Cysteine; Electrophoresis; Escherichia coli; Glycerophosphates; Histidine; Hydro-Lyases; Indoles; Isoenzymes; Lithium; Methionine; Potassium; Quaternary Ammonium Compounds; Serine; Sodium; Tryptophan | 1968 |
The purification and characterization of O-acetylserine sulfhydrylase-A from Salmonella typhimurium.
Topics: Amino Acids; Autoradiography; Carbon Isotopes; Chemical Phenomena; Chemical Precipitation; Chemistry; Chromatography, Gel; Chromatography, Thin Layer; Cysteine; Electrophoresis, Disc; Hydro-Lyases; Kinetics; Methods; Molecular Weight; Peptides; Pyridoxal Phosphate; Salmonella typhimurium; Serine; Spectrophotometry; Trypsin; Ultracentrifugation | 1969 |
O-alkylhomoserine and methionine biosynthesis in Corynebacterium.
Topics: Amino Acids; Corynebacterium; Culture Media; Cysteine; Escherichia coli; Homocysteine; Methionine; Serine; Threonine | 1969 |
Tyrosine phenol lyase. I. Purification, crystallization, and properties.
Topics: Alanine; Amino Acids; Ammonia; Catechols; Chemical Phenomena; Chemical Precipitation; Chemistry; Chromatography; Chromatography, Gel; Chromatography, Ion Exchange; Crystallization; Culture Media; Cysteine; Electrophoresis; Escherichia coli; Feedback; Kinetics; Lyases; Methods; Molecular Weight; Phenols; Protamines; Pyridoxal Phosphate; Pyruvates; Quaternary Ammonium Compounds; Serine; Stereoisomerism; Sulfates; Tyrosine; Ultracentrifugation | 1970 |
Synergism between cysteine and alkylating agents.
Topics: Alkanes; Alkylating Agents; Anti-Bacterial Agents; Cysteine; Drug Resistance, Microbial; Drug Synergism; Escherichia coli; Homocysteine; Nitroso Compounds; Serine; Stereoisomerism; Sulfonic Acids; Urethane | 1970 |
Horse liver alcohol dehydrogenase. The primary structure of the protein chain of the ethanol-active isoenzyme.
Topics: Alcohol Oxidoreductases; Alkylation; Amino Acid Sequence; Animals; Carbon Isotopes; Chemical Phenomena; Chemistry; Chromatography, Gel; Chymotrypsin; Cyanides; Cysteine; Ethanol; Histidine; Horses; Iodoacetates; Isoenzymes; Liver; Malates; Methionine; Mutation; Pepsin A; Peptides; Serine; Trypsin | 1970 |
Analogues of methionine as substrates and inhibitors of the methionine adenosyltransferase reaction. Deductions concerning the conformation of methionine.
Topics: Amino Acids; Animals; Chemical Phenomena; Chemistry; Cysteine; Escherichia coli; Glucosyltransferases; Liver; Methionine; Models, Structural; Rats; Saccharomyces; Serine; Time Factors | 1970 |
Horse liver alcohol dehydrogenase. The primary structure of an N-terminal part of the protein chain of the ethanol-active isoenzyme.
Topics: Alcohol Oxidoreductases; Amino Acid Sequence; Animals; Binding Sites; Carbon Isotopes; Chromatography, Gel; Chymotrypsin; Crustacea; Cyanides; Cysteine; Ethanol; Glyceraldehyde-3-Phosphate Dehydrogenases; Horses; Iodoacetates; Isoenzymes; Liver; Maleates; Pepsin A; Serine; Species Specificity; Swine; Trypsin; Tryptophan; Tyrosine | 1970 |
Regulation of L-cysteine biosynthesis in Salmonella typhimurium. I. Effects of growth of varying sulfur sources and O-acetyl-L-serine on gene expression.
Topics: Acetates; Acyltransferases; Adenine Nucleotides; Chromosome Mapping; Cysteine; Cystine; Enzyme Induction; Enzyme Repression; Genes, Regulator; Glutathione; Membrane Transport Proteins; Methylation; Mutation; Salmonella typhimurium; Serine; Sulfates; Sulfides; Sulfites; Sulfur; Sulfuric Acids | 1971 |
Fractionation of the nonpolar transfer ribonucleic acids from rat liver, yeast, and Escherichia coli by partition chromatography.
Topics: Amino Acid Sequence; Amino Acids; Animals; Arginine; Aspartic Acid; Chromatography; Chromatography, Gel; Cysteine; Escherichia coli; Genetic Code; Glutamates; Leucine; Liver; Lysine; Methionine; Nucleosides; Phenylalanine; Rats; RNA, Transfer; Saccharomyces; Serine; Species Specificity; Spectrophotometry; Tryptophan; Tyrosine; Ultraviolet Rays | 1971 |
RNA codons and protein synthesis. 15. Dissimilar responses of mammalian and bacterial transfer RNA fractions to messenger RNA codons.
Topics: Acylation; Amino Acid Sequence; Animals; Arginine; Carbon Isotopes; Chromatography; Cysteine; Escherichia coli; Genetic Code; Genetics, Microbial; Guinea Pigs; Isoleucine; Liver; Lysine; Methionine; Molecular Biology; Protein Binding; Protein Biosynthesis; Ribosomes; RNA, Bacterial; RNA, Messenger; RNA, Transfer; Serine; Threonine; Tritium | 1968 |
Regulation of tryptophanase formation in Escherichia coli.
Topics: Alanine; Amino Acids; Culture Media; Cysteine; Enzyme Activation; Escherichia coli; Glycine; Homoserine; Lysine; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Phenylalanine; Proteins; Serine; Time Factors | 1971 |
Serine metabolism in the culture form of Trypanosoma cruzi: synthesis of other amino acids.
Topics: Alanine; Amino Acids; Animals; Aspartic Acid; Carbon Isotopes; Chromatography, Ion Exchange; Cysteine; Glutamates; Glycine; Protein Biosynthesis; Proteins; Serine; Threonine; Trypanosoma cruzi | 1971 |
Reaction of the subunit of the Escherichia coli tryptophan synthetase with 1,5-difluoro-2,4-dinitrobenzene.
Topics: Amino Acid Sequence; Amino Acids; Carbon Isotopes; Catalysis; Chemical Phenomena; Chemistry; Chromatography, Gel; Cysteine; Escherichia coli; Fluorine; Glycerophosphates; Hydro-Lyases; Indoles; Kinetics; Lysine; Macromolecular Substances; Molecular Weight; Nitrobenzenes; Peptides; Serine; Spectrophotometry; Trypsin; Ultraviolet Rays | 1971 |
The B protein of Escherichia coli tryptophan synthetase. II. New -elimination and -replacement reactions.
Topics: Alanine; Carbon Isotopes; Chemical Phenomena; Chemistry; Chlorine; Cysteine; Escherichia coli; Ethers; Glycerophosphates; Hydro-Lyases; Indoles; Kinetics; Mercaptoethanol; Methanol; Models, Biological; Serine; Sulfhydryl Compounds; Sulfides; Tryptophan | 1971 |
Enzymatic formation of beta-cyanoalanine from cyanide.
Topics: Adenosine Triphosphate; Alanine; Chemical Phenomena; Chemistry; Chloromercuribenzoates; Cyanides; Cysteine; Edetic Acid; Hydroxylamines; Indicators and Reagents; Isoniazid; Magnesium; Mercury; Plants; Pyridoxal Phosphate; Semicarbazides; Serine | 1965 |
Properties of thiol-subtilisin. The consequences of converting the active serine residue to cysteine in a serine protease.
Topics: Acetates; Amino Acids; Bacillus subtilis; Binding Sites; Cysteine; Fluorescence; Hydrogen-Ion Concentration; Nitrophenols; Optical Rotatory Dispersion; Peptide Hydrolases; Protein Binding; Serine; Spectrum Analysis; Tryptophan; Ultracentrifugation; Ultraviolet Rays | 1968 |
Chromatography and activity of thiol-subtilisin.
Topics: Bacillus subtilis; Binding Sites; Chromatography, Ion Exchange; Cysteine; Peptide Hydrolases; Serine; Sulfhydryl Compounds | 1969 |
Purification and characterization of cysteine synthetase, a bifunctional protein complex, from Salmonella typhimurium.
Topics: Acyltransferases; Amino Acids; Animals; Chemical Phenomena; Chemical Precipitation; Chemistry; Chromatography, Gel; Chromatography, Ion Exchange; Coenzyme A; Cysteine; Electrophoresis, Disc; Hydro-Lyases; Immune Sera; Immunodiffusion; Kinetics; Methods; Molecular Weight; Peptides; Rabbits; Salmonella typhimurium; Serine; Sulfides; Ultracentrifugation | 1969 |
The localization of N6-(delta 2-isopentenyl) adenosine among the acceptor species of transfer ribonucleic acid of Lactobacillu acidophilus.
Topics: Alkenes; Amino Acids; Anhydrides; Carbon Isotopes; Cellulose; Chemical Phenomena; Chemical Precipitation; Chemistry; Chromatography; Chromatography, Ion Exchange; Culture Media; Cysteine; Genetic Code; Lactobacillus acidophilus; Leucine; Mevalonic Acid; Nucleosides; RNA, Bacterial; RNA, Transfer; Serine; Tritium; Tryptophan; Tyrosine | 1969 |
Pleiotrophy in a cysteine-requiring mutant of Samonella typhimurium resulting from altered protein-protein interaction.
Topics: Acyltransferases; Animals; Antigens; Chemical Precipitation; Chromatography, DEAE-Cellulose; Chromatography, Gel; Cysteine; Genes; Genetics, Microbial; Hot Temperature; Immune Sera; Immunodiffusion; Lyases; Methods; Mutation; Phenotype; Precipitin Tests; Rabbits; Salmonella typhimurium; Serine; Spectrophotometry | 1969 |
Purification and characterization of a lectin (plant hemagglutinin) with blood group A specificity from Dolichos biflorus.
Topics: ABO Blood-Group System; Adsorption; Amino Acids; Animals; Aspartic Acid; Binding Sites; Blood Group Antigens; Cysteine; Electrophoresis; Female; Hemagglutination Tests; Hexoses; Humans; Hydrogen-Ion Concentration; Immunodiffusion; Immunoelectrophoresis; Lectins; Methionine; Molecular Weight; Ovarian Cysts; Plant Lectins; Polysaccharides, Bacterial; Protein Binding; Rabbits; Seeds; Serine; Ultracentrifugation | 1970 |
Properties of L-serine deaminase from Salmonella typhi-murium and Bacillus cereus.
Topics: Bacillus cereus; Bacterial Proteins; Cysteine; Depression, Chemical; Hydro-Lyases; Hydrogen-Ion Concentration; L-Serine Dehydratase; Salmonella typhimurium; Serine; Stereoisomerism | 1969 |
[Recent studies on modifications of the sensitivity of Staphylococcus aureus to penicillin under the effect of amino acids].
Topics: Amino Acids; Cysteine; Cystine; Drug Antagonism; Drug Synergism; Glutamates; Microbial Sensitivity Tests; Penicillin G; Serine; Staphylococcus; Stereoisomerism | 1971 |
Human pancreatic enzymes. Isolation and properties of a major form of chymotrypsin.
Topics: Acetone; Amino Acids; Animals; Asparagine; Butanones; Calcium Chloride; Cattle; Chemical Phenomena; Chemical Precipitation; Chemistry; Chromatography, Gel; Chromatography, Ion Exchange; Chymotrypsin; Cysteine; Electrophoresis, Disc; Humans; Hydrogen-Ion Concentration; Immunodiffusion; Isoflurophate; Isoleucine; Molecular Weight; Pancreas; Quaternary Ammonium Compounds; Rabbits; Serine; Species Specificity; Spectrophotometry; Sulfates; Trypsin; Ultracentrifugation; Ultraviolet Rays | 1971 |
Cysteine and S-sulphocysteine biosynthesis in bacteria.
Topics: Acetates; Acyltransferases; Bacteria; Culture Media; Cysteine; Hydro-Lyases; Lyases; Molecular Weight; Pseudomonas aeruginosa; Serine; Sulfites; Sulfur; Thiosulfates | 1971 |
Solubilization and chemical and immunochemical characterization of sparingly soluble canine gastric mucin.
Topics: Alkylation; Amino Acids; Animals; Boron Compounds; Chemical Phenomena; Chemistry; Chromatography, DEAE-Cellulose; Chromatography, Gel; Chromatography, Thin Layer; Cysteine; Dogs; Electrophoresis; Ethylmaleimide; Fucose; Galactose; Gastric Mucins; Gastric Mucosa; Glucosamine; Glycoproteins; Hexosamines; Immunodiffusion; Immunoelectrophoresis; Neuraminic Acids; Oxidation-Reduction; Phosphates; Proline; Rabbits; Serine; Sodium; Sodium Chloride; Sodium Hydroxide; Solubility; Sulfhydryl Reagents; Sulfites; Sulfur Isotopes; Threonine | 1971 |
Formation of -cyanoalanine by O-acetylserine sulfhydrylase.
Topics: Acetates; Alanine; Ammonium Sulfate; Bacillus megaterium; Carbon Isotopes; Cell-Free System; Chemical Precipitation; Chromatography, DEAE-Cellulose; Colorimetry; Culture Media; Cyanides; Cysteine; Lyases; Protamines; Serine; Sulfates | 1971 |
Marine bacterial proteases. I. Characterization of an endopeptidase produced by Vibrio B-30.
Topics: Acetamides; Ammonium Sulfate; Ascorbic Acid; Calcium Chloride; Chemical Precipitation; Chloromercuribenzoates; Chromatography, DEAE-Cellulose; Chromatography, Gel; Cobalt; Copper; Crystallization; Cyanides; Cysteine; Cystine; Drug Stability; Edetic Acid; Electrophoresis; Endopeptidases; Enzyme Activation; Glutathione; Hydrogen-Ion Concentration; Iodoacetates; Isoflurophate; Kinetics; Magnesium; Manganese; Molecular Weight; Nickel; Potassium; Protease Inhibitors; Protein Denaturation; Serine; Temperature; Thioglycolates; Vibrio; Zinc | 1971 |
Structural studies of calf thymus F3 histone. I. Occurrence of cysteine, phosphoserine, and epsilon-N-acetyllysine in cyanogen bromide peptides.
Topics: Acetates; Acylation; Amino Acids; Animals; Carbon Isotopes; Cattle; Cell Nucleus; Chromatography, Gel; Cyanogen Bromide; Cysteine; Electrophoresis; Histones; Isotope Labeling; Lysine; Phosphates; Phosphopeptides; Phosphoric Acids; Phosphorus Isotopes; Serine; Thymus Gland | 1972 |
Influence of nutrition on the morphology of a strain of Bifidobacterium bifidum.
Topics: Acetates; Alanine; Amino Acids; Asparagine; Aspartic Acid; Culture Media; Cysteine; Glutamates; Lactobacillus; Mutation; Nutritional Physiological Phenomena; Quaternary Ammonium Compounds; Serine; Surface-Active Agents; Tryptophan | 1972 |
A chemical and crystallographic study of carbamyl-chymotrypsin A.
Topics: Acetates; Amino Acids; Animals; Binding Sites; Carbamates; Carbon Isotopes; Cattle; Chemical Phenomena; Chemistry; Chromatography, Gel; Chromatography, Ion Exchange; Chymotrypsin; Cyanates; Cyanides; Cyanogen Bromide; Cysteine; Glycine; Models, Structural; Nitrophenols; Pancreas; Phenylalanine; Protein Conformation; Serine; Succinates; Water; X-Ray Diffraction | 1972 |
Threonine dehydratase from goat liver.
Topics: Ammonium Sulfate; Animals; Chloromercuribenzoates; Chromatography, DEAE-Cellulose; Cysteine; Goats; Hydro-Lyases; Hydrogen-Ion Concentration; Kinetics; Liver; Pyridoxal Phosphate; Serine; Threonine | 1972 |
Serum aminotransferase activities and plasma free amino acid concentration as criteria for pyridoxine nutritional status of chicks.
Topics: Alanine Transaminase; Amino Acids; Aminobutyrates; Ammonia; Animal Nutritional Physiological Phenomena; Animals; Asparagine; Aspartate Aminotransferases; Body Weight; Chickens; Cysteine; Diet; Feeding Behavior; Glutamine; Glycine; Male; Ornithine; Pyridoxal Phosphate; Pyridoxine; Serine; Taurine; Vitamin B 6 Deficiency | 1972 |
Cystathionine -synthase. Studies of hydrogen exchange reactions.
Topics: Alanine; Aminobutyrates; Catalysis; Chemical Phenomena; Chemistry; Cystathionine; Cysteine; Deuterium; Homoserine; Kinetics; Lyases; Magnetic Resonance Spectroscopy; Pyridoxal Phosphate; Salmonella; Serine; Succinates; Tritium | 1972 |
[Differentiation of two cathepsins from cod muscle].
Topics: Animals; Cathepsins; Chemical Phenomena; Chemistry; Cysteine; Fishes; Histidine; Imidazoles; Muscles; Oxidation-Reduction; Peptide Hydrolases; Serine | 1971 |
Studies on the conformation of amino acids. IV. Conformations of serine, threonine, cysteine, and valine.
Topics: Amino Acids; Chemical Phenomena; Chemistry, Physical; Cysteine; Models, Structural; Serine; Thermodynamics; Threonine; Valine | 1971 |
Specificity and some other properties of liver serine sulphhydrase: evidence for its identity with cystathionine -synthase.
Topics: Acetates; Alanine; Amino Acids; Animals; Catalysis; Chickens; Chlorine; Chromatography, Gel; Chromatography, Paper; Cycloserine; Cysteamine; Cysteine; Electrophoresis, Paper; Glycolates; Homocysteine; Hydro-Lyases; Hydroxylamines; Isoelectric Focusing; Kinetics; L-Serine Dehydratase; Liver; Mercaptoethanol; Nitriles; Penicillamine; Propionates; Pyridoxal Phosphate; Rats; Serine; Species Specificity; Sulfhydryl Compounds; Sulfides; Sulfuric Acids; Thioglycolates | 1971 |
Identification of one of the L-serine dehydratase isoenzymes from rat liver as L-homoserine dehydratase.
Topics: Animals; Centrifugation, Density Gradient; Chromatography, Gel; Cystathionine; Cysteine; Cystine; Female; Homoserine; Hydro-Lyases; Isoenzymes; L-Serine Dehydratase; Liver; Molecular Weight; Rats; Serine; Threonine | 1971 |
Effect of substrate structure on coupling ratio for Na + -dependent transport of amino acids.
Topics: Alanine; Amino Acids; Animals; Asparagine; Biological Transport; Carbon Isotopes; Columbidae; Cysteine; Erythrocytes; Hydroxyproline; Kinetics; Models, Biological; Models, Structural; Potassium; Potassium Isotopes; Proline; Serine; Sodium; Sodium Chloride; Sodium Isotopes; Structure-Activity Relationship; Threonine; Tritium | 1971 |
The effect of vitamin C depletion on the free amino acid content in blood plasma of the guinea pig.
Topics: Alanine; Amino Acids; Ammonia; Animals; Arginine; Ascorbic Acid Deficiency; Aspartic Acid; Citrulline; Cysteine; Glutamates; Glycine; Guinea Pigs; Histidine; Isoleucine; Lysine; Male; Methionine; Ornithine; Phenylalanine; Proline; Serine; Threonine; Time Factors; Tyrosine; Valine | 1971 |
[Dissociation of S- and P-variants of Bacillus brevis var. G.-B. on a synthetic medium with amino acids as the only source of nitrogen].
Topics: Alanine; Amino Acids; Aspartic Acid; Bacillus; Culture Media; Cysteine; Genetic Variation; Glycine; Histidine; Leucine; Lysine; Mutation; Nitrogen; Ornithine; Phenylalanine; Serine; Stimulation, Chemical; Threonine; Time Factors; Tryptophan; Valine | 1971 |
Sequence and structure of a cysteinyl flavin peptide from monoamine oxidase.
Topics: Amino Acid Sequence; Aminopeptidases; Binding Sites; Chromatography, Paper; Cysteine; Electrophoresis, Paper; Flavin-Adenine Dinucleotide; Fluorometry; Formates; Glycine; Hydrolysis; Indicators and Reagents; Liver; Monoamine Oxidase; Oxidation-Reduction; Peptides; Protein Binding; Serine; Spectrophotometry; Tyrosine | 1971 |
Group separation: a new method facilitating isolation of peptides from digests of high molecular weight proteins.
Topics: Anhydrides; Arginine; Carboxypeptidases; Chromatography, Ion Exchange; Chymotrypsin; Cysteine; Endopeptidases; Histidine; Imides; Lysine; Maleates; Methionine; Methods; Peptides; Phosphoproteins; Proteins; Serine; Trypsin | 1971 |
Allosteric properties of skeletal muscle pyruvate kinase.
Topics: Alanine; Allosteric Regulation; Animals; Cysteine; Drug Interactions; Enzyme Activation; Glyceric Acids; Hydrogen-Ion Concentration; Kinetics; Muscles; Phenylalanine; Pyruvate Kinase; Rabbits; Serine | 1971 |
The conversion of serine at the active site of subtilisin to cysteine: a "chemical mutation".
Topics: Chemical Phenomena; Chemistry; Cysteine; Endopeptidases; Mutation; Serine | 1966 |
Comparison of invariant residues in the variable and constant regions of human K, human L, and mouse K Bence-Jones proteins.
Topics: Amino Acid Sequence; Animals; Bence Jones Protein; Cysteine; Glutamates; Histidine; Humans; In Vitro Techniques; Leucine; Lysine; Mice; Phenylalanine; Proline; Serine; Tryptophan; Valine | 1967 |
Amino acid fermentation by Fusobacterium nucleatum.
Topics: Amino Acids; Aspartic Acid; Cysteine; Fermentation; Fusobacterium; Gingiva; Glutamates; Glutamine; Histidine; Humans; Lysine; Methionine; Mouth; Serine; Threonine | 1968 |
The nature of general base-general acid catalysis in serine proteases.
Topics: Binding Sites; Chemical Phenomena; Chemistry; Cysteine; Deuterium; Endopeptidases; Histidine; Kinetics; Models, Chemical; Models, Structural; Serine | 1969 |
Amino acid replacements associated with reversion and recombination within a coding unit.
Topics: Alanine; Amino Acids; Aspartic Acid; Cysteine; Escherichia coli; Genetic Code; Genetics; Glycine; In Vitro Techniques; Isoleucine; Ligases; Lysine; Mutation; Peptides; Serine; Tryptophan; Valine | 1965 |
Enzymatic formation of beta-cyanoalanine from cyanide by Escherichia coli extracts.
Topics: Adenosine Triphosphate; Alanine; Carbon Isotopes; Chemical Phenomena; Chemistry; Cyanides; Cysteine; Escherichia coli; Magnesium; Serine; Sulfides; Threonine | 1965 |
The enzymic synthesis of L-cysteine in Escherichia coli and Salmonella typhimurium.
Topics: Acyltransferases; Chromatography, Thin Layer; Cysteine; Escherichia coli; Kinetics; Ligases; Molecular Biology; Mutation; Salmonella typhimurium; Serine; Streptomycin; Sulfides; Ultracentrifugation | 1966 |
A kinetic study of the reaction mechanism of tryptophanase-catalyzed reactions.
Topics: Acrylates; Chemical Phenomena; Chemistry; Cysteine; Escherichia coli; Indoles; Kinetics; Lyases; Pyruvates; Serine; Spectrophotometry; Tryptophan | 1967 |
Enzymatic synthesis of cystathionine by extracts of spinach, requiring O-acetylhomoserine or O-succinylhomoserine.
Topics: Amino Acids; Carbon Isotopes; Cysteine; Electrophoresis; Escherichia coli; Ligases; Methionine; Plants, Edible; Serine; Sulfur; Sulfur Isotopes | 1966 |
Enzymatic synthesis of homocysteine or methionine directly from O-succinyl-homoserine.
Topics: Amino Acids; Cysteine; Hydrogen; Methionine; Salmonella typhimurium; Serine; Succinates; Sulfides | 1967 |
[Quantitative evaluation of by paper and thin layer chromatographically separated amino acids with 1,3-dimethyl alloxan].
Topics: Alloxan; Amino Acids; Arginine; Aspartic Acid; Chromatography, Paper; Chromatography, Thin Layer; Cysteine; Drug Stability; Indicators and Reagents; Methionine; Methods; Peptides; Phenylalanine; Serine; Tryptophan | 1969 |
Studies on amino acid racemases. I. Partial purification and properties of the alanine racemase from Lactobacillus fermenti.
Topics: Acetates; Alanine; Aminobutyrates; Aspartic Acid; Centrifugation, Density Gradient; Chromatography, DEAE-Cellulose; Chromatography, Gel; Computers; Cysteine; Drug Stability; Glutamates; Glutathione; Hydrogen-Ion Concentration; Isomerases; Kinetics; Lactobacillus; Mercaptoethanol; Methods; Models, Biological; Models, Chemical; Pyridoxal Phosphate; Serine; Stereoisomerism; Temperature | 1969 |
Transaminase activity in sheep rumen content.
Topics: Alanine; Alanine Transaminase; Animals; Arginine; Aspartic Acid; Cysteine; Eukaryota; Glutamates; Hydrogen-Ion Concentration; Isoleucine; Leucine; Methionine; Phenylalanine; Rumen; Serine; Sheep; Temperature; Threonine; Tryptophan; Tyrosine; Valine | 1969 |
Amino acid transport into human platelets and subsequent incorporation into protein.
Topics: Amino Acids; Biological Transport; Blood Platelets; Blood Proteins; Carbon Isotopes; Cell Membrane; Cysteine; Fibrin; Fibrinogen; Glutamates; Humans; Leucine; Lysine; Microscopy, Electron; Mitochondria; Proline; Puromycin; Serine; Thrombin; Valine | 1970 |
Studies on the mechanism of fatty acid synthesis. 23. The acyl binding sites of the pigeon liver fatty acid synthetase.
Topics: Acetates; Amides; Amino Acids; Animals; Binding Sites; Caproates; Carbon Isotopes; Chromatography, Ion Exchange; Coenzyme A; Columbidae; Cysteine; Ethylmaleimide; Fatty Acids; Ligases; Liver; Malonates; Oxidation-Reduction; Serine; Sulfhydryl Compounds | 1970 |
Thiol and disulphide contents of hen ovalbumin. C-terminal sequence and location of disulphide bond.
Topics: Animals; Carbon Isotopes; Chickens; Chloromercuribenzoates; Chromatography; Cysteine; Electrophoresis; Female; Imines; Iodoacetates; Ovalbumin; Peptides; Proline; Serine; Sulfides; Trypsin; Valine | 1970 |
Molecular weight and amino acid composition of five-times-crystallized phosphoglucose isomerase from rabbit skeletal muscle.
Topics: Amides; Amino Acids; Animals; Barium; Chemical Phenomena; Chemistry; Chromatography, Ion Exchange; Crystallization; Cysteine; Diffusion; Glucose-6-Phosphate Isomerase; Hydrochloric Acid; Hydroxides; Molecular Weight; Muscles; Nitrogen; Oxygen; Rabbits; Serine; Threonine; Tryptophan; Tyrosine; Ultracentrifugation; Viscosity | 1970 |
Partial purification and properties of choline kinase from the cockroach, Periplaneta americana.
Topics: Adenosine Triphosphate; Amino Alcohols; Animals; Calcium Phosphates; Carbon Isotopes; Carnitine; Chemical Precipitation; Choline; Cysteine; Drug Stability; Hydrogen-Ion Concentration; Insecta; Kinetics; Magnesium; Methods; Nucleotides; Phosphotransferases; Quaternary Ammonium Compounds; Serine; Sulfates; Time Factors; Ultracentrifugation | 1970 |
[Biosynthesis of gramicidin C on synthetic media with amino acids as the only N source].
Topics: Alanine; Amino Acids; Aspartic Acid; Bacillus; Culture Media; Cysteine; Glycine; Histidine; Hydrogen-Ion Concentration; Leucine; Lysine; Nitrogen; Ornithine; Phenylalanine; Serine; Threonine; Tryptophan; Tyrothricin; Valine | 1970 |
Homocystinuria due to cystathionine synthase deficiency: the effect of pyridoxine.
Topics: Adult; Aldehydes; Autoanalysis; Carbon Isotopes; Chromatography; Cysteine; Diet; Diet Therapy; Enzyme Activation; Female; Fibroblasts; Homocystine; Homocystinuria; Humans; Hydro-Lyases; Keto Acids; L-Serine Dehydratase; Liver; Male; Methionine; Pyridoxal Phosphate; Pyridoxine; Serine; Sulfates; Trypsin | 1970 |
Amino acid sequence analysis with methyl isothiocyanate. Resolution of the methylthiohydantoins by gas-liquid partition chromatography.
Topics: Alanine; Amino Acid Sequence; Amino Acids; Animals; Aspartic Acid; Bence Jones Protein; Cattle; Chromatography, Gas; Cysteine; Dipeptides; Glutamates; Hydantoins; Indicators and Reagents; Insulin; Methods; Serine; Serum Albumin, Bovine; Solvents; Thiocyanates; Threonine | 1970 |
Determination of pico-mole quantities of gamma-amino-butyric acid (GABA) and serotonin.
Topics: Alanine; Amino Acids; Aminobutyrates; Animals; Arginine; Aspartic Acid; Autoradiography; Brain Chemistry; Carbon Isotopes; Cerebellum; Chromatography; Cysteine; Cystine; Glutamates; Glycine; Histidine; In Vitro Techniques; Isoleucine; Leucine; Lysine; Methods; Microchemistry; Phenylalanine; Proline; Radionuclide Imaging; Rats; Serine; Serotonin; Threonine; Tyrosine; Valine | 1970 |
[Role of endogenous histamine in the protective effect of radiation-protective agents].
Topics: Animals; beta-Aminoethyl Isothiourea; Cystamine; Cysteamine; Cysteine; Gastric Mucosa; Histamine; Kidney; Liver; Male; Radiation Injuries, Experimental; Radiation-Protective Agents; Rats; Serine; Serotonin; Skin; Snakes; Venoms | 1970 |
Biosynthesis of Se-methylselenocysteine and S-methylcysteine in Astragalus bisulcatus.
Topics: Carbon Isotopes; Chromatography; Cysteine; Methionine; Plants; Selenium; Serine; Sulfur | 1970 |
Sphingolipid biosynthesis by a rat brain particulate fraction.
Topics: Amino Alcohols; Animals; Brain; Catalysis; Cerebrosides; Chemical Phenomena; Chemistry; Choline; Chromatography, Thin Layer; Cysteine; Fatty Acids; Galactose; Glucose; Glycols; Lipids; Microscopy, Electron; Nucleotides; Rats; Serine | 1970 |
[Correlation between Parkinsonism symptoms and a disorder in the amino acid metabolism in CNS].
Topics: Amino Acids; Animals; Brain Injuries; Central Nervous System Diseases; Cerebrospinal Fluid; Cysteine; Cystine; Diagnosis, Differential; Glycine; Humans; Parkinson Disease; Parkinson Disease, Postencephalitic; Phenothiazines; Rats; Serine; Threonine; Tremor | 1970 |
A new hypothesis on the evolution of the genetic code.
Topics: Amino Acids; Arginine; Asparagine; Biological Evolution; Cysteine; Genetic Code; Glutamine; Leucine; Lysine; Methionine; Models, Chemical; Models, Structural; Nucleotides; Proline; Serine; Threonine; Tyrosine | 1970 |
[Effect of amino acids on the growth of Streptococcus lactis and biosynthesis of nisin].
Topics: Alanine; Amino Acids; Anti-Bacterial Agents; Arginine; Asparagine; Aspartic Acid; Culture Media; Cysteine; Cystine; Depression, Chemical; Glutamates; Glycine; Histidine; Leucine; Lysine; Methionine; Ornithine; Phenylalanine; Proline; Serine; Stimulation, Chemical; Streptococcus; Threonine; Tryptophan; Valine | 1970 |
[Effect of vitamin E and selenium on glycine-2-C 14 and formate-C 14 incorporation in rat liver glutathione].
Topics: Animals; Carbon Isotopes; Cysteine; Formates; Glutathione; Glycine; Liver; Methionine; Rats; Selenium; Serine; Vitamin E | 1970 |
Acid protease from germinated sorghum. 1. Purification and characterization of the enzyme.
Topics: Albumins; Animals; Binding Sites; Cattle; Chelating Agents; Chemical Phenomena; Chemistry; Chromatography, DEAE-Cellulose; Chromatography, Gel; Crystallization; Cysteine; Electrophoresis, Disc; Endopeptidases; Hydrogen-Ion Concentration; Kinetics; Molecular Weight; Plants; Seeds; Serine; Serum Albumin, Bovine; Sulfhydryl Compounds; Temperature; Urea | 1970 |
Purification and characterization of L-serine transacetylase and O-acetyl-L-serine sulfhydrylase from kidney bean seedlings (Phaseolus vulgaris).
Topics: Acetates; Acyltransferases; Carbon Isotopes; Chemical Precipitation; Chloromercuribenzoates; Chromatography, DEAE-Cellulose; Chromatography, Gel; Cysteine; Ethylmaleimide; Hydrogen-Ion Concentration; Lyases; Plants; Pyridoxal Phosphate; Quaternary Ammonium Compounds; Serine; Sulfates; Sulfhydryl Reagents | 1971 |
Studies on the conformation of amino acids. IX. Conformations of butyl, seryl, threonyl, cystennyl, and valyl residues in a dipeptide unit.
Topics: Amino Acids; Butylamines; Cysteine; Dipeptides; Energy Transfer; Serine; Threonine; Valine | 1971 |
Biosynthesis of -cyanoalanine in Vicia sativa.
Topics: Alanine; Carbon Isotopes; Cyanides; Cysteine; Glutamates; Nitriles; Plants; Potassium; Protein Binding; Serine; Time Factors; Toxins, Biological | 1971 |
[Dissociation of R- and P plus-variants of Bacillus brevis var. G.-B. during growth on a synthetic medium with amino acids as the only source of nitrogen].
Topics: Alanine; Amino Acids; Aspartic Acid; Bacillus; Culture Media; Cysteine; Genetic Variation; Glycine; Histidine; Leucine; Lysine; Nitrogen; Ornithine; Phenylalanine; Serine; Threonine; Tryptophan; Valine | 1971 |
Acyl-transfer reactions of amides and esters with alcohols and thiols. A reference system for the serine and cysteine proteinases. Concerning the N protonation of amides and amide-imidate equilibria.
Topics: Acyltransferases; Alcohols; Amides; Chymotrypsin; Cysteine; Endopeptidases; Esters; Papain; Serine; Sulfur; Thermodynamics | 1971 |
S-carboxymethylcysteine from the photolysis of diazoacyl trypsin and chymotrypsin.
Topics: Azo Compounds; Binding Sites; Carbon Isotopes; Chemical Phenomena; Chemistry; Chromatography, Ion Exchange; Chromatography, Thin Layer; Chymotrypsin; Cysteine; Electrophoresis; Formates; Hydrogen Peroxide; Malonates; Oxidation-Reduction; Photolysis; Serine; Sulfides; Trypsin | 1971 |
Serine transhydroxymethylase. Affinity of the active site for substrates, substrate analogues, and anions.
Topics: Alanine; Aldehydes; Aminoisobutyric Acids; Animals; Benzoates; Binding Sites; Chlorides; Cysteamine; Cysteine; Electrophoresis; Folic Acid; Glycine; Hot Temperature; Hydrogen-Ion Concentration; Kinetics; Mercaptoethanol; Models, Biological; Organophosphonates; Phosphates; Potassium; Propionates; Pyridoxal Phosphate; Rabbits; Serine; Spectrophotometry; Stereoisomerism; Sulfates; Sulfhydryl Compounds; Sulfonic Acids; Thermodynamics; Threonine; Transferases; Ultracentrifugation | 1971 |
Transsulfuration in higher plants. Partial purification and properties of beta-cystathionase of spinach.
Topics: Alanine; Amino Acids; Benzoates; Carbon Isotopes; Chemical Phenomena; Chemistry; Chromatography, Paper; Cysteine; Drug Stability; Edible Grain; Ethylmaleimide; Homocysteine; Hydro-Lyases; Hydrogen-Ion Concentration; Hydroxylamines; Kinetics; Models, Structural; Plants; Pyridoxal Phosphate; Pyruvates; Quaternary Ammonium Compounds; Serine; Species Specificity; Spectrophotometry; Stereoisomerism; Sulfates; Sulfides; Sulfur; Triticum | 1971 |
Studies on adrenal steroid hydroxylases. The reactivity of triphenyl phosphine with labile sulfur in adrenal iron-sulfur protein (adrenodoxin).
Topics: Adrenal Glands; Air; Alanine; Animals; Benzene Derivatives; Bromine; Cattle; Chemical Phenomena; Chemistry; Chromatography, Gel; Cysteine; Ferredoxins; Hydrocarbons, Halogenated; Iron; Kinetics; Models, Structural; Nickel; Nitrogen; Organometallic Compounds; Phosphines; Pyruvates; Serine; Spectrophotometry; Sulfhydryl Compounds; Sulfides; Trichloroacetic Acid; Tritium | 1971 |
Mutation of Saccharomyces cerevisiae preventing uptake of S-adenosylmethionine.
Topics: Adenine; Carbon Isotopes; Colorimetry; Crosses, Genetic; Culture Media; Cysteine; Genetics, Microbial; Homocysteine; Methionine; Mutation; Nucleosides; S-Adenosylmethionine; Saccharomyces; Serine; Threonine | 1971 |
Cystathionine synthase from rat liver: partial purification and properties.
Topics: Amino Acids; Animals; Benzoates; Boron Compounds; Calcium Phosphates; Carbon Isotopes; Chromatography, Gel; Cysteine; Drug Stability; Electrophoresis; Enzyme Activation; Homocysteine; Hydro-Lyases; Hydrogen-Ion Concentration; Hydroxylamines; Kinetics; L-Serine Dehydratase; Liver; Mercury; Oxidation-Reduction; Protamines; Pyridoxal Phosphate; Quaternary Ammonium Compounds; Rats; Serine; Spectrophotometry; Sulfates; Sulfides; Temperature | 1971 |
A study of L-(14C)cystathionine metabolism in the brain, kidney, and liver of pyridoxine-deficient rats.
Topics: Amino Acids; Ammonia; Animals; Biological Transport; Brain; Carbon Isotopes; Chromatography, Ion Exchange; Chromatography, Paper; Cysteine; Homocysteine; Hydro-Lyases; Injections; Keto Acids; Kidney; L-Serine Dehydratase; Liver; Male; Proteins; Pyridoxine; Rats; Serine; Time Factors; Vitamin B 6 Deficiency | 1971 |
[Free amino acids and other ninhydrin-positive substances in the normal horny layer and in psoriasis scales].
Topics: Alanine; Amino Acids; Ammonia; Asparagine; Chromatography; Citrulline; Cysteine; Glycine; Histidine; Humans; Imidazoles; Phenylalanine; Proline; Psoriasis; Serine; Skin; Taurine; Threonine; Urea | 1967 |
[Synthesis of the bovine insulin A-chain according to the Merrifield method, using exclusively the p-nitrophenyl esters of tert.-butyloxycarbonyl-amino acids].
Topics: Amino Acids; Animals; Cattle; Cysteine; Insulin; Isoleucine; Nitrophenols; Peptides; Serine; Solutions; Spectrophotometry; Valine | 1967 |
[Quantitative paper chromatography amino acid determination. Stanardization of the procedure and method of testing of new paper types].
Topics: Alanine; Amino Acids; Arginine; Aspartic Acid; Chromatography, Paper; Cysteine; Glutamates; Glycine; Histidine; Indicators and Reagents; Leucine; Lysine; Methionine; Methods; Paper; Phenylalanine; Serine; Spectrum Analysis; Sulfones; Threonine; Tyrosine; Ultraviolet Rays; Valine | 1967 |
Ammonia production by rumen microbes in vitro.
Topics: Alanine; Amino Acids; Ammonia; Animals; Arginine; Asparagine; Aspartic Acid; Cysteine; Glutamates; Glutamine; Glycine; Histidine; Hydrogen-Ion Concentration; Isoleucine; Leucine; Lysine; Methionine; Phenylalanine; Proline; Rumen; Serine; Threonine; Tryptophan; Tyrosine; Valine | 1967 |
Cysteine biosynthesis in Pasteurella multocida. Cysteine synthase, purification and properties.
Topics: Adsorption; Aspartate Aminotransferases; Calcium Phosphates; Cell-Free System; Cellulose; Centrifugation, Zonal; Chemical Precipitation; Chromatography, Ion Exchange; Colorimetry; Cysteine; Hydro-Lyases; Hydrogen-Ion Concentration; Ions; Kinetics; Oxidoreductases; Pasteurella; Pyridoxal Phosphate; Serine; Sulfides; Sulfur Isotopes | 1968 |
Proton retention in the gamma-elimination reaction catalysed by cystathionine gamma-synthase.
Topics: Cysteine; Deuterium; Dinitrophenols; Hydrazines; Hydro-Lyases; Hydrogen; Keto Acids; Magnetic Resonance Spectroscopy; Protons; Pyridoxal Phosphate; Serine; Succinates; Tritium; Water | 1968 |
A model for sulfhydryl groups in proteins. Hydrophobic interactions of the cystein side chain in micelles.
Topics: Alkanes; Amides; Binding Sites; Chemical Phenomena; Chemistry; Coloring Agents; Cysteine; Glycine; Methods; Models, Chemical; Proteins; Serine; Spectrophotometry; Sulfhydryl Compounds | 1968 |
Sulfuration of O-acetylhomoserine and O-acetylserine by two enzyme fractions from spinach.
Topics: Cysteine; Ethionine; Mercaptoethanol; Methionine; Plant Extracts; Plant Proteins; Plants, Edible; Serine; Sulfur | 1968 |
Enzymatic synthesis of cysteine and S-methylcysteine in plant extracts.
Topics: Carbon Isotopes; Cysteine; Enzymes; Hot Temperature; Neurospora; Plant Extracts; Plants, Edible; Saccharomyces; Serine; Sulfides; Sulfur Isotopes | 1968 |
Inhibition of heat-induced denaturation of serum proteins by mixtures of nonsteroidal anti-inflammatory agents and amino acids.
Topics: Amino Acids; Anti-Inflammatory Agents; Arthritis, Rheumatoid; Cysteine; Depression, Chemical; Flufenamic Acid; Fluorine; Histamine; Histidine; Hot Temperature; Indomethacin; ortho-Aminobenzoates; Phenylalanine; Phenylbutazone; Protein Denaturation; Serine; Serum Albumin, Bovine; Solutions; Tryptophan; Tyrosine | 1968 |
The biosynthesis of cystathionine in patients with homocystinuria.
Topics: Amino Acid Metabolism, Inborn Errors; Amino Acids; Animals; Brain; Child; Child, Preschool; Chromatography, Ion Exchange; Cysteine; Diet Therapy; Homocystinuria; Humans; Hydro-Lyases; Intellectual Disability; Liver; Rats; Serine; Sulfur Isotopes | 1968 |
Primary structure of insoluble tendon collagen. 3. Analysis of products of tryptic digestion of native collagen.
Topics: Achilles Tendon; Alanine; Aldehydes; Amino Acids; Animals; Arginine; Cattle; Chromatography, Gel; Chromatography, Ion Exchange; Collagen; Cysteine; Electrophoresis; Glutamine; Glycine; Hexosamines; Histidine; Isoleucine; Leucine; Lysine; Methionine; Methods; Phenylalanine; Proline; Serine; Sulfur; Threonine; Trypsin; Tyrosine; Valine | 1968 |
Trace metal requirements for malformin biosynthesis.
Topics: Alanine; Amino Acids; Anti-Bacterial Agents; Arginine; Aspartic Acid; Aspergillus; Chromium; Cobalt; Copper; Cysteine; Glutamine; Glycine; Histidine; Iron; Isoleucine; Leucine; Lysine; Manganese; Metals; Molybdenum; Peptide Biosynthesis; Phenylalanine; Plant Growth Regulators; Proline; Serine; Trace Elements; Tryptophan; Tyrosine; Valine; Zinc | 1968 |
The circular dichroism of polypeptide films.
Topics: Acetates; Alkylation; Chemical Phenomena; Chemistry; Cysteine; Lysine; Peptides; Serine; Spectrum Analysis; Valine | 1968 |
Kinetics of the photochemical addition of [35S] cysteine to polynucleotides and nucleic acids.
Topics: Animals; Cattle; Chemical Phenomena; Chemistry; Cysteine; DNA; Kinetics; Methionine; Polynucleotides; RNA; Saccharomyces; Serine; Sulfur Isotopes; Threonine; Thymus Gland; Tyrosine; Ultraviolet Rays | 1968 |
[On the influence of the starting position on migration of substances in paper electrophoresis].
Topics: Alanine; Amino Acids; Aminobutyrates; Arginine; Asparagine; Cysteine; Electrophoresis; Glucose; Glutamates; Glutamine; Glycine; Histidine; Leucine; Lysine; Methionine; Serine; Serum Albumin; Taurine; Tryptophan | 1968 |
The enzymic synthesis of cysteine from inorganic sulphide and L-serine by rat liver preparations.
Topics: Animals; Culture Techniques; Cysteine; Enzyme Induction; Enzyme Precursors; Ethylmaleimide; Hydro-Lyases; Hydrogen-Ion Concentration; Infrared Rays; Kinetics; Liver; Male; Rats; Serine; Spectrum Analysis; Sulfides; Sulfur Isotopes | 1968 |
Effect of chronic pyridoxine deficiency and a pyridoxal antagonist on the assimilation of sulphide by the cysteine synthase reaction in the rat.
Topics: Amino Acid Oxidoreductases; Animals; Cysteine; Hydro-Lyases; In Vitro Techniques; Kidney; Liver; Male; Pancreas; Pyridoxine; Rats; Serine; Sulfides; Vitamin B 6 Deficiency | 1968 |
Cyanide metabolism in higher plants. IV. Purification and properties of the beta-cyanolanine synthase of blue lupine.
Topics: Alanine; Cell-Free System; Centrifugation, Density Gradient; Chromatography, Gel; Colorimetry; Cyanides; Cysteine; Electrophoresis; Lyases; Plants, Edible; Serine; Sulfides; Toxins, Biological | 1969 |
Reactions catalysed by serine sulfhydrase from chicken liver.
Topics: Animals; Chickens; Chromatography, Gel; Chromatography, Ion Exchange; Chromatography, Paper; Cysteamine; Cysteine; Homocysteine; Hydro-Lyases; Liver; Mercaptoethanol; Serine; Sulfides | 1969 |
Amino-acid receptor in larvae of Pieris brassicae (Lepidoptera).
Topics: Action Potentials; Amino Acids; Aminobutyrates; Animals; Chemoreceptor Cells; Cysteine; Glutamates; Glycine; Insecta; Leucine; Methionine; Proline; Serine; Stimulation, Chemical | 1969 |
Synthesis of the antibiotic nisin: formation of lanthionine and beta-methyl-lanthionine.
Topics: Amino Acids; Anti-Bacterial Agents; Carbon Isotopes; Cysteine; Electrophoresis; Serine; Streptococcus; Sulfides; Sulfur Isotopes; Threonine; Tritium | 1969 |
Structure of Mn2+ and Cu2+ complexes with L-methionine, S-methyl-L-cysteine, L-threonine and L-serine.
Topics: Alanine; Amino Acids; Aminobutyrates; Binding Sites; Chemical Phenomena; Chemistry; Copper; Cysteine; Drug Stability; Keto Acids; Magnetic Resonance Spectroscopy; Manganese; Methionine; Serine; Sulfur; Threonine | 1969 |
The specificity of purified porcine pancreatic elastase.
Topics: Alanine; Animals; Chromatography; Cysteine; Electrophoresis; Glutamates; Glycine; Histidine; Insulin; Leucine; Pancreas; Pancreatic Elastase; Phenylalanine; Serine; Swine; Valine | 1969 |
Determination of dinitrophenylamino acids in structural proteins by chromatography on nylon powder columns. I. The water-soluble dinitrophenylamino acids.
Topics: Amino Acids; Animals; Chromatography; Collagen; Cysteine; Dinitrophenols; Hair; Hydrogen-Ion Concentration; Lysine; Methods; Nylons; Proteins; Serine; Textiles; Tyrosine; Wool | 1969 |
Stereochemical specificity of neutral amino acid transfer systems in rat small intestine.
Topics: Alanine; Amino Acids; Animals; Biological Transport; Carbon Isotopes; Cysteine; Hydroxyproline; Ileum; Intestine, Small; Jejunum; Leucine; Methionine; Pipecolic Acids; Proline; Rats; Sarcosine; Serine; Stereoisomerism | 1969 |
Biosynthesis of insulin chains A and B.
Topics: Animals; Carbon Isotopes; Cysteine; Glycine; In Vitro Techniques; Insulin; Methylthiouracil; Pancreas; Radiometry; Rats; Serine; Sulfur Isotopes; Tyrosine | 1965 |
The labeling in vitro of glutathione of human blood cells.
Topics: Blood Cells; Cell Membrane Permeability; Cysteine; Cystine; Fluorides; Glucose; Glutathione; Glycine; Hemolysis; Humans; In Vitro Techniques; Phosphates; Plasma Substitutes; Serine; Sulfur Isotopes | 1965 |
The reaction of iodoacetamide with the active center of gamma-glutamyl transpeptidase.
Topics: Alkylation; Amides; Animals; Autoradiography; Borates; Catalysis; Cattle; Cysteine; Electrophoresis; Enzymes; Glycolates; Histidine; In Vitro Techniques; Kidney; Lysine; Methionine; Molecular Weight; Serine; Transferases | 1965 |
Transformation of L-serine to L-cysteine.
Topics: Chemical Phenomena; Chemistry; Cysteine; Serine | 1965 |
Alterations in serine metabolism in rats fed liquid synthetic diets.
Topics: Alcohol Oxidoreductases; Animals; Cysteine; Diet; Glycerolphosphate Dehydrogenase; Glycine; Hydro-Lyases; Liver; Rats; Serine | 1966 |
Effects of 2 nephrotoxic agents on newborn rats.
Topics: Animals; Animals, Newborn; Cysteine; Kidney Cortex Necrosis; Kidney Tubules; Rats; Serine | 1966 |
On the synthesis of taurine from sulfate by the chick. I. Influential dietary factors.
Topics: Alanine; Amino Alcohols; Animals; Cysteine; Diet; Glycine; In Vitro Techniques; Kidney; Liver; Myocardium; Poultry; Pyruvates; Serine; Spleen; Sulfates; Sulfites; Taurine; Thiosulfates | 1966 |
Water relations of Salmonella oranienburg; stimulation of respiration by amino acids.
Topics: Alanine; Asparagine; Aspartic Acid; Carbon Isotopes; Culture Media; Cysteine; Glucose; Glutamine; Glycine; Methionine; Oxygen Consumption; Proline; Salmonella; Serine; Threonine; Water | 1966 |
Analysis of N-methylamino acids by automatic amino acid analyzer and gas-liquid chromatography.
Topics: Alanine; Anti-Bacterial Agents; Arginine; Aspartic Acid; Autoanalysis; Chromatography, Gas; Cysteine; Cystine; Glutamates; Glycine; Indicators and Reagents; Isoleucine; Lysine; Phenylalanine; Serine; Threonine; Tyrosine; Valine | 1966 |
[Composition and properties of the preparations isolated from Act. coelicolor with the aid of beta-naphtol].
Topics: Acetates; Actinomyces; Alanine; Arginine; Aspartic Acid; Chromatography, Paper; Cysteine; Glucosamine; Glutamates; Glycerol; Leucine; Lysine; Naphthalenes; Peptides; Phosphates; Ribose; Serine; Valine | 1966 |
[Synthesis of cysteine in skin homogenates].
Topics: Animals; Autoradiography; Culture Techniques; Cysteine; Liver; Pyridoxal Phosphate; Rabbits; Serine; Sheep; Skin; Sulfur Isotopes | 1966 |
Synthesis of homocysteine and cysteine by enzyme extracts of spinach.
Topics: Amino Acids; Chromatography, Paper; Cysteine; Electrophoresis; Homocysteine; In Vitro Techniques; Methionine; Plant Extracts; Plants, Edible; Serine; Sulfides; Sulfur Isotopes; Threonine; Vegetables | 1967 |
The optical rotatory dispersion of two beta structures.
Topics: Chemical Phenomena; Chemistry, Physical; Cysteine; Peptides; Serine; Spectrum Analysis | 1967 |
The mechanism of the reaction of beta-hydroxyaspartate with L-aspartate beta-decarboxylase. A new type of pyridoxal 5'-phosphate-enzyme inhibition.
Topics: Alcaligenes; Aldehydes; Amino Acids; Aspartic Acid; Carbon Dioxide; Carbon Isotopes; Carboxy-Lyases; Chromatography, Gel; Cysteine; Enzymes; Hydrazones; Phenylhydrazines; Pyridoxal Phosphate; Serine; Spectrophotometry; Sulfinic Acids | 1967 |
Electron microscopic and biochemical characterization of collagen in blattarian insects.
Topics: Alanine; Ammonia; Animals; Arginine; Aspartic Acid; Collagen; Connective Tissue Cells; Cysteine; Cystine; Female; Glutamates; Glycine; Histidine; Histocytochemistry; Hydroxyproline; Insecta; Isoleucine; Leucine; Lysine; Male; Methionine; Microscopy, Electron; Phenylalanine; Proline; Serine; Threonine; Tyrosine; Valine | 1967 |
The reactivity of thiol-subtilisin, an enzyme containing a synthetic functional group.
Topics: Benzoates; Carbon Isotopes; Chemical Phenomena; Chemistry; Cinnamates; Cysteine; Endopeptidases; Hydrogen-Ion Concentration; Kinetics; Nitrophenols; Phenylacetates; Serine; Spectrophotometry | 1967 |
Rapid short-column chromatography of amino acids. A method for blood and urine specimens in the diagnosis and treatment of metabolic disease.
Topics: Alanine; Amino Acid Metabolism, Inborn Errors; Amino Acids; Aminobutyrates; Autoanalysis; Buffers; Chromatography, Ion Exchange; Citrates; Cysteine; Cystine; Glutamates; Glutamine; Glycine; Humans; Hydrogen-Ion Concentration; Hydroxyproline; Isoleucine; Phenylalanine; Proline; Sarcosine; Serine; Threonine; Tyrosine; Valine | 1967 |
Requirements for growth of Streptococcus agalactiae in a chemically defined medium.
Topics: Alanine; Ascorbic Acid; Asparagine; Aspartic Acid; Culture Media; Cysteine; Cystine; Proline; Serine; Streptococcus; Thioglycolates | 1967 |
The influence of nitrogenous compounds on growth of Pythium species.
Topics: Alanine; Amino Acids; Aminobutyrates; Asparagine; Aspartic Acid; Cysteine; Fungi; Glutamates; Glycine; Histidine; Hydrogen-Ion Concentration; Nitrates; Nitrites; Nitrogen; Peptones; Quaternary Ammonium Compounds; Serine; Succinates; Threonine; Yeast, Dried | 1967 |
A distinct Na+-requiring transport system for alanine, serine, cysteine, and similar amino acids.
Topics: Alanine; Amino Acids; Animals; Carcinoma, Ehrlich Tumor; Cysteine; Depression, Chemical; Kinetics; Radiation Effects; Serine; Sodium | 1967 |
Synthesis of selenium-containing peptides.
Topics: Benzene Derivatives; Chemical Phenomena; Chemistry; Cysteine; Methods; Models, Chemical; Oxytocin; Peptides; Selenium; Serine | 1967 |
Pharmacological evidence for a distinct leukotriene C4 receptor in guinea-pig trachea.
Topics: Animals; Chromones; Cysteine; Guinea Pigs; In Vitro Techniques; Leukotriene E4; Male; Muscle Contraction; Receptors, Cell Surface; Receptors, Leukotriene; Receptors, Prostaglandin; Serine; SRS-A; Trachea | 1984 |
Effect of amino acids on microbial production of citric acid by Aspergillus niger.
Topics: Amino Acids; Aspartic Acid; Aspergillus niger; Citrates; Citric Acid; Cysteine; Glutamates; Glutamic Acid; Lysine; Serine | 1982 |
Pharmacological and biochemical evidence for metabolism of peptide leukotrienes by guinea-pig airway smooth muscle in vitro.
Topics: Aminopeptidases; Animals; Carbachol; Cysteine; Dose-Response Relationship, Drug; gamma-Glutamyltransferase; Guinea Pigs; Histamine; In Vitro Techniques; Leukotriene E4; Male; Muscle Contraction; Serine; SRS-A; Trachea | 1984 |
Bioconversion of C-6 sulfidopeptide leukotrienes by the responding guinea pig ileum determines the time course of its contraction.
Topics: Animals; Cysteine; Depression, Chemical; Guinea Pigs; Ileum; Intestinal Mucosa; Leukotriene E4; Muscle Contraction; Receptors, Cell Surface; Receptors, Leukotriene B4; Serine; SRS-A; Time Factors | 1983 |
Plasma serine to cysteine ratio as a biological marker for psychosis.
Topics: Adolescent; Adult; Chromatography, Gas; Cysteine; Female; Humans; Male; Middle Aged; Psychotic Disorders; Serine; Time Factors | 1983 |
Human duodenal gland (Brunner's gland) mucus glycoprotein analysis.
Topics: Amino Acids; Animals; Brunner Glands; Carbohydrates; Centrifugation, Density Gradient; Chromatography, Gel; Cysteine; Duodenum; Glycoproteins; Humans; Mucus; Rats; Serine; Threonine | 1984 |
Purification and properties of thiol beta-lactamase. A mutant of pBR322 beta-lactamase in which the active site serine has been replaced with cysteine.
Topics: Amino Acid Sequence; beta-Lactamases; Binding Sites; Circular Dichroism; Cysteine; Escherichia coli; Kinetics; Mutation; Plasmids; Serine; Substrate Specificity | 1984 |
Intrahelical hydrogen bonding of serine, threonine and cysteine residues within alpha-helices and its relevance to membrane-bound proteins.
Topics: Cysteine; Hydrogen Bonding; Membrane Proteins; Protein Conformation; Serine; Threonine | 1984 |
Site-specific mutagenesis of the human interleukin-2 gene: structure-function analysis of the cysteine residues.
Topics: Amino Acid Sequence; Base Sequence; Cell Line; Cysteine; DNA, Recombinant; Escherichia coli; Genes; Humans; Interleukin-2; Mutation; Receptors, Immunologic; Receptors, Interleukin-2; Serine; Structure-Activity Relationship | 1984 |
Peptic peptide of thiolsubtilisin. Analytical evidence for the chemical transformation of the essential serine-221 to cysteine-221.
Topics: Amino Acid Sequence; Binding Sites; Chemical Phenomena; Chemistry; Cysteine; Oligopeptides; Pepsin A; Peptide Fragments; Serine; Subtilisins; Sulfhydryl Compounds | 1981 |
Amino acid transport via the red cell anion transport system.
Topics: 4-Acetamido-4'-isothiocyanatostilbene-2,2'-disulfonic Acid; Alanine; Amino Acids; Biological Transport; Carrier Proteins; Cysteine; Depression, Chemical; Erythrocytes; Glycine; Humans; In Vitro Techniques; Proline; Serine; Threonine; Valine | 1981 |
Copper induction of translatable metallothionein messenger RNA.
Topics: Animals; Copper; Cysteine; Electrophoresis, Polyacrylamide Gel; Leucine; Liver; Male; Metalloproteins; Metallothionein; Protein Biosynthesis; Rats; Rats, Inbred Strains; RNA, Messenger; Serine; Sulfates; Zinc; Zinc Sulfate | 1981 |
Chemical modification of Lactobacillus casei thymidylate synthetase with 1-fluoro-2,4-dinitrobenzene and 1,5-difluoro-2,4-dinitrobenzene.
Topics: Binding Sites; Chemical Phenomena; Chemistry; Cross-Linking Reagents; Cysteine; Dinitrofluorobenzene; Fluorides; Kinetics; Lacticaseibacillus casei; Macromolecular Substances; Methyltransferases; Nitrobenzenes; Serine; Thymidylate Synthase | 1982 |
The transport of alanine, serine, and cysteine in cultured human fibroblasts.
Topics: Alanine; Amino Acids; Amino Acids, Cyclic; Aminoisobutyric Acids; Biological Transport; Cells, Cultured; Cysteine; Fibroblasts; Humans; Kinetics; Serine; Sodium | 1982 |
Redesigning enzyme structure by site-directed mutagenesis: tyrosyl tRNA synthetase and ATP binding.
Topics: Adenosine Triphosphate; Amino Acyl-tRNA Synthetases; Base Sequence; Binding Sites; Cysteine; Genes, Bacterial; Genetic Engineering; Geobacillus stearothermophilus; Mutation; Serine; Structure-Activity Relationship; Tyrosine-tRNA Ligase | 1982 |
Metabolism of L-[sulfane-34S]thiocystine by Escherichia coli.
Topics: Cysteine; Cystine; Deuterium; Escherichia coli; Hydrogen Sulfide; Serine; Sulfur Isotopes | 1982 |
Thiol-beta-lactamase: replacement of the active-site serine of RTEM beta-lactamase by a cysteine residue.
Topics: Amino Acid Sequence; Ampicillin; Base Sequence; beta-Lactamase Inhibitors; beta-Lactamases; Binding Sites; Chloromercuribenzoates; Cysteine; Escherichia coli; Genes; Genetic Engineering; Penicillin Resistance; Serine; Structure-Activity Relationship | 1982 |
Hemoglobin Nigeria (alpha-81 Ser replaced by Cys):a new variant associated with alpha-thalassemia.
Topics: Absorption; Anemia, Sickle Cell; Chromatography, Ion Exchange; Cysteine; Erythrocytes; Female; Genetic Variation; Hemoglobin A; Hemoglobin, Sickle; Hemoglobins; Hemoglobins, Abnormal; Humans; Nigeria; Oxygen; Pedigree; Serine; Sulfhydryl Reagents; Thalassemia | 1980 |
Decreased cysteine and proline synthesis in parenterally fed, premature infants.
Topics: Alanine; Amino Acids; Aspartic Acid; Birth Weight; Blood Glucose; Carbon Isotopes; Cysteine; Electrolytes; Energy Intake; Female; Food, Formulated; Gas Chromatography-Mass Spectrometry; Gestational Age; Glucose; Glutamic Acid; Glycine; Humans; Infant Food; Infant Nutritional Physiological Phenomena; Infant, Newborn; Infant, Premature; Lipids; Male; Parenteral Nutrition; Parenteral Nutrition Solutions; Proline; Serine; Solutions | 1995 |
Use of protease sensitivity to probe the conformations of newly synthesised mutant forms of mitochondrial aspartate aminotransferase.
Topics: Alanine; Animals; Aspartate Aminotransferases; Cell-Free System; Cysteine; Kinetics; Mitochondria, Liver; Mutagenesis, Site-Directed; Plasmids; Point Mutation; Pronase; Protein Conformation; Rats; Recombinant Fusion Proteins; Serine; Tetrahydrofolate Dehydrogenase | 1995 |
Mutation of the carboxy terminal zinc finger of E. coli isoleucyl-tRNA synthetase alters zinc binding and aminoacylation activity.
Topics: Amino Acid Sequence; Base Sequence; Cysteine; DNA Primers; Enterobacter; Escherichia coli; Isoleucine-tRNA Ligase; Kinetics; Molecular Sequence Data; Mutagenesis, Site-Directed; Point Mutation; Polymerase Chain Reaction; Pseudomonas fluorescens; Recombinant Proteins; Sequence Homology, Amino Acid; Serine; Staphylococcus aureus; Zinc Fingers | 1995 |
Binding of phenylarsenoxide to Arg-tRNA protein transferase is independent of vicinal thiols.
Topics: Acyltransferases; Alanine; Aminoacyltransferases; Arsenicals; Base Sequence; Cysteine; DNA Primers; Iodine Radioisotopes; Molecular Sequence Data; Mutagenesis, Site-Directed; Protein Binding; Saccharomyces cerevisiae; Serine; Sulfhydryl Compounds | 1995 |
Cysteine 17 of recombinant human granulocyte-colony stimulating factor is partially solvent-exposed.
Topics: Amino Acid Sequence; Animals; CHO Cells; Cloning, Molecular; Cricetinae; Cysteine; Disulfides; Escherichia coli; Glycosylation; Granulocyte Colony-Stimulating Factor; Guanidine; Guanidines; Humans; Hydrogen-Ion Concentration; Kinetics; Mutagenesis, Site-Directed; Point Mutation; Protein Conformation; Recombinant Proteins; Serine; Solvents; Spectrophotometry, Infrared; Transfection | 1993 |
NMDA receptor channels: subunit-specific potentiation by reducing agents.
Topics: Alanine; Animals; Base Sequence; Cell Line; Cloning, Molecular; Cysteine; Dithiothreitol; Drug Synergism; Ethylmaleimide; Glutamates; Glutamic Acid; Glutathione; Humans; Ion Channels; Kidney; Kinetics; Macromolecular Substances; Membrane Potentials; Molecular Sequence Data; Mutagenesis, Site-Directed; Oligodeoxyribonucleotides; Rats; Receptors, N-Methyl-D-Aspartate; Recombinant Fusion Proteins; Serine; Transfection | 1994 |
Analysis of the posttranslational modifications of the influenza virus M2 protein.
Topics: Amino Acid Sequence; Animals; Cysteine; HeLa Cells; Humans; Influenza A virus; Ion Channels; Molecular Sequence Data; Oocytes; Phosphorylation; Protein Processing, Post-Translational; Serine; Viral Matrix Proteins; Xenopus laevis | 1995 |
Characterization of lipoamide dehydrogenase from Escherichia coli lacking the redox active disulfide: C44S and C49S.
Topics: Cysteine; Dihydrolipoamide Dehydrogenase; Disulfides; Escherichia coli; Flavin-Adenine Dinucleotide; Hydrogen-Ion Concentration; Mutagenesis, Site-Directed; NAD; Oxidation-Reduction; Serine; Spectrometry, Fluorescence; Spectrophotometry; Sulfhydryl Compounds | 1995 |
Lipoamide dehydrogenase from Escherichia coli lacking the redox active disulfide: C44S and C49S. Redox properties of the FAD and interactions with pyridine nucleotides.
Topics: Binding Sites; Coloring Agents; Cysteine; Dihydrolipoamide Dehydrogenase; Disulfides; Electron Transport; Escherichia coli; Flavin-Adenine Dinucleotide; Hydrogen-Ion Concentration; Kinetics; Mutagenesis, Site-Directed; NAD; NADP; Oxidation-Reduction; Phenazines; Serine; Viologens | 1995 |
Effect of cysteine to serine mutations on the properties of the [4Fe-4S] center in Escherichia coli fumarate reductase.
Topics: Amino Acid Sequence; Binding Sites; Cysteine; DNA Mutational Analysis; Electron Spin Resonance Spectroscopy; Escherichia coli; Iron-Sulfur Proteins; Molecular Sequence Data; Mutagenesis, Site-Directed; Potentiometry; Sequence Homology, Amino Acid; Serine; Structure-Activity Relationship; Succinate Dehydrogenase | 1995 |
Identification, expression, and pharmacology of a Cys23-Ser23 substitution in the human 5-HT2c receptor gene (HTR2C).
Topics: Animals; Base Sequence; Chromosome Mapping; Cysteine; Electrophysiology; Gene Expression; Gene Frequency; Genetic Linkage; Genetic Variation; Humans; Molecular Sequence Data; Oocytes; Point Mutation; Receptor, Serotonin, 5-HT2C; Receptors, Serotonin; Serine; Serotonin; Xenopus laevis | 1995 |
The role of palmitoylation of the guanine nucleotide binding protein G11 alpha in defining interaction with the plasma membrane.
Topics: Amino Acid Sequence; Animals; Base Sequence; Cell Line; Cell Membrane; Chlorocebus aethiops; Chromatography, Gel; Cysteine; Cytosol; DNA Primers; DNA, Complementary; Electrophoresis, Polyacrylamide Gel; Genetic Variation; GTP-Binding Proteins; Mice; Molecular Sequence Data; Mutagenesis, Site-Directed; Palmitic Acid; Palmitic Acids; Point Mutation; Polymerase Chain Reaction; Protein Processing, Post-Translational; Recombinant Proteins; Sequence Homology, Amino Acid; Serine; Transfection | 1995 |
Nature and environment of the sulfhydryls of membrane-associated D-lactate dehydrogenase of Escherichia coli.
Topics: Bacterial Outer Membrane Proteins; Cysteine; Disulfides; Dithionitrobenzoic Acid; Escherichia coli; Kinetics; L-Lactate Dehydrogenase; Mutagenesis, Site-Directed; Nitrobenzoates; Serine; Sulfhydryl Compounds; Sulfhydryl Reagents | 1995 |
Characterization of a dominant negative mutant of the cell cycle ubiquitin-conjugating enzyme Cdc34.
Topics: Amino Acid Sequence; Anaphase-Promoting Complex-Cyclosome; Binding Sites; Cell Cycle; Cloning, Molecular; Cysteine; Fungal Proteins; Gene Expression; Genes, Dominant; Genes, Fungal; Leucine; Ligases; Molecular Sequence Data; Mutagenesis, Site-Directed; Point Mutation; Protein Conformation; Recombinant Proteins; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Serine; Ubiquitin-Conjugating Enzymes; Ubiquitin-Protein Ligase Complexes; Ubiquitin-Protein Ligases | 1995 |
Replacements of histidine 226 of NhaA-Na+/H+ antiporter of Escherichia coli. Cysteine (H226C) or serine (H226S) retain both normal activity and pH sensitivity, aspartate (H226D) shifts the pH profile toward basic pH, and alanine (H226A) inactivates the ca
Topics: Alanine; Aspartic Acid; Codon; Cysteine; Escherichia coli; Histidine; Hydrogen-Ion Concentration; Mutagenesis, Site-Directed; Phenotype; Point Mutation; Serine; Sodium-Hydrogen Exchangers | 1995 |
Characterization of FNR* mutant proteins indicates two distinct mechanisms for altering oxygen regulation of the Escherichia coli transcription factor FNR.
Topics: Aerobiosis; Amino Acid Sequence; Anaerobiosis; Bacterial Proteins; Cysteine; DNA-Binding Proteins; Escherichia coli; Escherichia coli Proteins; Gene Expression Regulation, Bacterial; Iron-Sulfur Proteins; Lac Operon; Models, Genetic; Molecular Sequence Data; Mutation; Oxygen; Promoter Regions, Genetic; Protein Binding; Serine; Structure-Activity Relationship | 1995 |
Molecular cloning and characterization of a plant serine acetyltransferase playing a regulatory role in cysteine biosynthesis from watermelon.
Topics: Acetyltransferases; Allosteric Regulation; Amino Acid Sequence; Amino Acids; Amino Acids, Cyclic; Base Sequence; Blotting, Northern; Blotting, Southern; Cloning, Molecular; Cysteine; Cysteine Synthase; DNA, Complementary; Fruit; Genes, Plant; Molecular Sequence Data; Multienzyme Complexes; Recombinant Proteins; Sequence Analysis, DNA; Sequence Homology, Amino Acid; Serine; Serine O-Acetyltransferase | 1995 |
Cytosine methyltransferase from Escherichia coli in which active site cysteine is replaced with serine is partially active.
Topics: Base Sequence; Binding Sites; Catalysis; Cysteine; Cytosine; DNA (Cytosine-5-)-Methyltransferases; DNA, Recombinant; Escherichia coli; Methylation; Molecular Sequence Data; Mutagenesis, Site-Directed; Oligodeoxyribonucleotides; Serine | 1995 |
The unique extracellular disulfide loop of the glycine receptor is a principal ligand binding element.
Topics: Amino Acid Sequence; Binding Sites; Cells, Cultured; Cysteine; Disulfides; Extracellular Matrix; Glycine; Humans; Kinetics; Ligands; Lysine; Molecular Sequence Data; Mutagenesis, Site-Directed; Mutation; Protein Conformation; Receptors, Glycine; Serine; Strychnine; Taurine; Threonine; Tyrosine | 1995 |
Characterization of a mutated rubredoxin with a cysteine ligand of the iron replaced by serine.
Topics: Base Sequence; Binding Sites; Clostridium; Cysteine; DNA Primers; Electron Spin Resonance Spectroscopy; Iron; Ligands; Molecular Sequence Data; Oxidation-Reduction; Point Mutation; Polymerase Chain Reaction; Rubredoxins; Serine; Spectrophotometry; Spectrophotometry, Ultraviolet; Spectrum Analysis, Raman | 1995 |
ATP-dependent inactivation of the beta-Ser339Cys mutant F1-ATPase from Escherichia coli by N-ethylmaleimide.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Base Sequence; Cysteine; Edetic Acid; Escherichia coli; Ethylmaleimide; Hydrogen-Ion Concentration; Molecular Sequence Data; Mutagenesis, Site-Directed; Proton-Translocating ATPases; Serine; Structure-Activity Relationship | 1995 |
Pattern formation on cardiac troponin I by consecutive phosphorylation and dephosphorylation.
Topics: Amino Acid Sequence; Animals; Cattle; Cyclic AMP-Dependent Protein Kinases; Cysteine; Kinetics; Molecular Sequence Data; Myocardium; Peptide Fragments; Phosphoprotein Phosphatases; Phosphorylation; Phosphoserine; Protein Phosphatase 2; Serine; Troponin; Troponin I | 1995 |
Involvement of cysB and cysE genes in the sensitivity of Salmonella typhimurium to mecillinam.
Topics: Acetyltransferases; Amdinocillin; Bacterial Proteins; Cysteine; Drug Resistance, Microbial; Escherichia coli Proteins; Gene Expression Regulation, Bacterial; Genes, Bacterial; Mutation; Regulon; Salmonella typhimurium; Serine; Serine O-Acetyltransferase; Sulfides; Sulfites; Thiosulfates | 1995 |
Disruption of the disulfide bridge in azurin from Pseudomonas aeruginosa.
Topics: Azurin; Circular Dichroism; Copper; Cysteine; Disulfides; Electron Spin Resonance Spectroscopy; Models, Molecular; Mutagenesis, Site-Directed; Mutation; Pseudomonas aeruginosa; Serine; Spectrometry, Fluorescence; Spectrophotometry | 1995 |
The importance of the GTP-binding protein tissue transglutaminase in the regulation of cell cycle progression.
Topics: Animals; Binding Sites; Blotting, Western; Cell Cycle; Cell Division; Cricetinae; Cysteine; DNA; Fibrosarcoma; GTP-Binding Proteins; Homeostasis; Humans; Mutagenesis, Site-Directed; Point Mutation; Protein Processing, Post-Translational; Recombinant Proteins; Serine; Transfection; Transglutaminases; Tumor Cells, Cultured | 1995 |
Cumulative effects of mutations in newly synthesised mitochondrial aspartate aminotransferase on uptake into mitochondria.
Topics: Alanine; Amino Acid Sequence; Animals; Aspartate Aminotransferases; Cysteine; Kinetics; Mitochondria; Mutagenesis, Site-Directed; Point Mutation; Protein Processing, Post-Translational; Recombinant Proteins; Serine | 1995 |
Inhibition of skin development by overexpression of transforming growth factor beta 1 in the epidermis of transgenic mice.
Topics: Amino Acid Sequence; Animals; Animals, Newborn; Cysteine; DNA; Gene Expression; Immunohistochemistry; Introns; Mice; Mice, Transgenic; Microscopy, Electron; Mutagenesis, Site-Directed; Reference Values; RNA; Serine; Skin; Swine; Transforming Growth Factor beta | 1993 |
Refined structures of the active Ser83-->Cys and impaired Ser46-->Asp histidine-containing phosphocarrier proteins.
Topics: Aspartic Acid; Bacterial Proteins; Binding Sites; Crystallography, X-Ray; Cysteine; Mutation; Phosphoenolpyruvate Sugar Phosphotransferase System; Protein Conformation; Protein Folding; Serine | 1994 |
Hepatic expression of mature transforming growth factor beta 1 in transgenic mice results in multiple tissue lesions.
Topics: Animals; Apoptosis; Cell Division; Cells, Cultured; Codon; Crosses, Genetic; Cysteine; DNA, Complementary; Female; Gene Expression; Glomerulonephritis; Inflammation; Kidney; Liver; Liver Cirrhosis, Experimental; Male; Mice; Mice, Inbred C57BL; Mice, Inbred CBA; Mice, Transgenic; Mitosis; Mutagenesis, Site-Directed; Myocardium; Restriction Mapping; Serine; Swine; Transforming Growth Factor beta | 1995 |
No major role for the dopamine D2 receptor Ser-->Cys311 mutation in schizophrenia.
Topics: Alleles; Cysteine; Female; France; Gene Frequency; Humans; Male; Pedigree; Point Mutation; Receptors, Dopamine D2; Schizophrenia; Serine; White People | 1994 |
In vivo sulfhydryl modification of the ligand-binding site of Tsr, the Escherichia coli serine chemoreceptor.
Topics: Bacterial Proteins; Binding Sites; Cysteine; Escherichia coli; Ethylmaleimide; Ligands; Membrane Proteins; Mutagenesis, Site-Directed; Serine; Threonine | 1995 |
Hydroxyl radical footprints and half-site arrangements of binding sites for the CysB transcriptional activator of Salmonella typhimurium.
Topics: Bacterial Proteins; Base Sequence; Binding Sites; Cysteine; DNA-Binding Proteins; DNA, Bacterial; Gene Expression Regulation, Bacterial; Hydroxyl Radical; Models, Genetic; Models, Molecular; Molecular Sequence Data; Nucleic Acid Conformation; Promoter Regions, Genetic; Protein Binding; Protein Conformation; Salmonella typhimurium; Serine; Transcription Factors; Transcription, Genetic | 1995 |
Electrospray-ionization mass spectrometry of molecular variants of a [2Fe-2S] ferredoxin.
Topics: Alanine; Apoproteins; Clostridium; Cysteine; Ferredoxins; Genetic Variation; Iron; Macromolecular Substances; Mass Spectrometry; Mutagenesis, Site-Directed; Protein Conformation; Recombinant Proteins; Serine; Sulfur | 1995 |
A ser for Cys mutation in the extracellular portion of insulin receptor beta subunit impairs the insulin-insulin receptor complex internalization in CHO cells.
Topics: Animals; Base Sequence; Binding Sites; CHO Cells; Cricetinae; Cysteine; DNA Primers; Down-Regulation; Humans; Insulin; Molecular Sequence Data; Mutagenesis, Site-Directed; Polymerase Chain Reaction; Receptor, Insulin; Recombinant Proteins; Restriction Mapping; Serine; Transfection | 1995 |
Crystallographic analyses of NADH peroxidase Cys42Ala and Cys42Ser mutants: active site structures, mechanistic implications, and an unusual environment of Arg 303.
Topics: Alanine; Arginine; Binding Sites; Catalysis; Crystallography, X-Ray; Cysteine; Mutation; Peroxidases; Protein Structure, Tertiary; Serine | 1995 |
Computer modelling of the alpha-helical coiled coil: packing of side-chains in the inner core.
Topics: Alanine; Amino Acid Sequence; Arginine; Asparagine; Aspartic Acid; Computer Simulation; Cysteine; Glutamates; Glutamine; Histidine; Hydrogen Bonding; Isoleucine; Leucine; Lysine; Methionine; Models, Molecular; Molecular Sequence Data; Protein Structure, Secondary; Serine; Thermodynamics; Threonine; Tyrosine; Valine | 1995 |
Intra-A chain disulfide bond (A6-11) of insulin is essential for displaying its activity.
Topics: Amino Acid Sequence; Animals; Antibodies; Base Sequence; Cysteine; Disulfides; DNA Primers; Electrophoresis, Polyacrylamide Gel; Humans; Insulin; Molecular Sequence Data; Molecular Weight; Mutagenesis, Site-Directed; Point Mutation; Proinsulin; Protein Conformation; Radioligand Assay; Receptor, Insulin; Recombinant Proteins; Serine; Swine | 1994 |
Covalent dimerization of vascular permeability factor/vascular endothelial growth factor is essential for its biological activity. Evidence from Cys to Ser mutations.
Topics: Binding, Competitive; Biopolymers; Cysteine; Endothelial Growth Factors; Lymphokines; Mutation; Serine; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors | 1994 |
Identification of the reactive cysteine in clostridial glutamate dehydrogenase by site-directed mutagenesis and proof that this residue is not strictly essential.
Topics: Base Sequence; Cloning, Molecular; Clostridium; Cysteine; Dithionitrobenzoic Acid; Escherichia coli; Glutamate Dehydrogenase; Molecular Sequence Data; Mutagenesis, Site-Directed; Serine; Structure-Activity Relationship | 1994 |
Penicillin acylase has a single-amino-acid catalytic centre.
Topics: Amino Acid Sequence; Binding Sites; Catalysis; Computer Graphics; Crystallography, X-Ray; Cysteine; Escherichia coli; Histidine; Molecular Sequence Data; Penicillin Amidase; Protein Conformation; Serine | 1995 |
Modification of glutathione S-transferase 3-3 mutants with 2-(S-glutathionyl)-3,5,6-trichloro-1,4-benzoquinone. Identification of the C-terminal tryptic fragment as part of the H-site and evidence that 2-(S-glutathionyl)-3,5,6-trichloro-1,4-benzoquinone i
Topics: Amino Acid Sequence; Animals; Binding Sites; Chloranil; Cysteine; Dithiothreitol; Enzyme Inhibitors; Glutathione; Glutathione Transferase; Mass Spectrometry; Molecular Sequence Data; Mutation; Peptide Fragments; Peptide Mapping; Rats; Serine | 1994 |
Lipoprotein lipase: role of intramolecular disulfide bonds in enzyme catalysis.
Topics: Amino Acid Sequence; Base Sequence; Catalysis; Cloning, Molecular; Cysteine; Disulfides; DNA, Complementary; Humans; Lipoprotein Lipase; Molecular Sequence Data; Mutagenesis, Site-Directed; Oligodeoxyribonucleotides; Plasmids; Point Mutation; Recombinant Proteins; Restriction Mapping; Serine | 1995 |
Site-directed mutagenesis of vacuolar H(+)-pyrophosphatase. Necessity of Cys634 for inhibition by maleimides but not catalysis.
Topics: Alanine; Amino Acid Sequence; Arabidopsis; Base Sequence; Catalysis; Cysteine; DNA, Complementary; Ethylmaleimide; Molecular Sequence Data; Mutagenesis, Site-Directed; Pyrophosphatases; Saccharomyces cerevisiae; Serine; Vacuoles | 1995 |
Localization of the disulfide bond involved in post-translational processing of glycosylasparaginase and disrupted by a mutation in the Finnish-type aspartylglycosaminuria.
Topics: Amino Acid Sequence; Aspartylglucosylaminase; Carbohydrate Metabolism, Inborn Errors; Cysteine; Disulfides; Finland; Humans; Leukocytes; Macromolecular Substances; Mass Spectrometry; Molecular Sequence Data; Peptide Fragments; Point Mutation; Protein Processing, Post-Translational; Serine | 1995 |
Amino-terminal palmitate or polybasic domain can provide required second signal to myristate for membrane binding of p56lck.
Topics: Amino Acid Sequence; Binding Sites; Cell Membrane; Cysteine; HeLa Cells; Humans; Lymphocyte Specific Protein Tyrosine Kinase p56(lck); Molecular Sequence Data; Mutagenesis, Site-Directed; Myristic Acid; Myristic Acids; Plasmids; Point Mutation; Protein-Tyrosine Kinases; Recombinant Proteins; Serine; Signal Transduction; Transfection | 1995 |
Isoprenylation of brain 2',3'-cyclic nucleotide 3'-phosphodiesterase modulates cell morphology.
Topics: 2',3'-Cyclic-Nucleotide Phosphodiesterases; Amino Acid Sequence; Animals; Antibodies; Base Sequence; Brain; Cells, Cultured; Codon; Cysteine; Cytoplasm; Electrophoresis, Polyacrylamide Gel; Glioma; Molecular Sequence Data; Mutagenesis, Site-Directed; Oligodendroglia; Point Mutation; Protein Biosynthesis; Protein Prenylation; Rabbits; Rats; Recombinant Fusion Proteins; Serine; Transcription, Genetic; Transfection; Tumor Cells, Cultured | 1994 |
Galectin-1, a beta-galactoside-binding lectin in Chinese hamster ovary cells. I. Physical and chemical characterization.
Topics: Amino Acid Sequence; Animals; Antibody Specificity; Base Sequence; Blotting, Western; CHO Cells; Cloning, Molecular; Cricetinae; Cysteine; DNA Primers; Drug Stability; Escherichia coli; Galactose; Galectin 1; Hemagglutinins; Kinetics; Lectins; Macromolecular Substances; Molecular Sequence Data; Molecular Weight; Mutagenesis, Site-Directed; Point Mutation; Rats; Recombinant Proteins; Restriction Mapping; Sequence Homology, Amino Acid; Sequence Homology, Nucleic Acid; Serine; Time Factors | 1995 |
A fluorescent probe study of plasminogen activator inhibitor-1. Evidence for reactive center loop insertion and its role in the inhibitory mechanism.
Topics: 4-Chloro-7-nitrobenzofurazan; Amino Acid Sequence; Base Sequence; Binding Sites; Cysteine; Fluorescent Dyes; Kinetics; Molecular Sequence Data; Mutagenesis, Site-Directed; Oligodeoxyribonucleotides; Oxadiazoles; Plasminogen Activator Inhibitor 1; Point Mutation; Protein Conformation; Protein Structure, Secondary; Recombinant Proteins; Serine; Spectrometry, Fluorescence; Tissue Plasminogen Activator; Urokinase-Type Plasminogen Activator | 1995 |
Identification of two functionally distinct lysine-binding sites in kringle 37 and in kringles 32-36 of human apolipoprotein(a).
Topics: Amino Acid Sequence; Apolipoproteins; Apoprotein(a); Base Sequence; Binding Sites; Carcinoma, Hepatocellular; Cell Line; Chromatography, Affinity; Cysteine; DNA, Complementary; Enzyme-Linked Immunosorbent Assay; Humans; Immunoblotting; Kringles; Lipoprotein(a); Liver Neoplasms; Lysine; Models, Structural; Molecular Sequence Data; Mutagenesis, Site-Directed; Oligodeoxyribonucleotides; Plasmids; Protein Conformation; Protein Structure, Secondary; Recombinant Proteins; Serine; Transfection; Tryptophan; Tumor Cells, Cultured | 1995 |
Ligand-mediated changes in the tryptophan synthase indole tunnel probed by nile red fluorescence with wild type, mutant, and chemically modified enzymes.
Topics: Amino Acid Sequence; Base Sequence; Binding Sites; Cloning, Molecular; Codon; Computer Graphics; Computer Simulation; Cysteine; Escherichia coli; Fluorescent Dyes; Indoles; Iodides; Kinetics; Ligands; Macromolecular Substances; Models, Molecular; Molecular Sequence Data; Mutagenesis, Site-Directed; Oligodeoxyribonucleotides; Oxazines; Phenylalanine; Point Mutation; Protein Conformation; Pyridoxal Phosphate; Recombinant Proteins; Salmonella typhimurium; Serine; Spectrometry, Fluorescence; Tryptophan; Tryptophan Synthase | 1995 |
Cystine uptake and glutathione level in fetal brain cells in primary culture and in suspension.
Topics: Animals; beta-Alanine; Biological Transport; Brain; Cells, Cultured; Cysteine; Cystine; Female; Fetus; Glutamates; Glutamic Acid; Glutathione; In Vitro Techniques; Kinetics; Neurons; Pregnancy; Rats; Rats, Wistar; Serine; Sodium; Time Factors | 1993 |
A structural polymorphism of human dopamine D2 receptor, D2(Ser311-->Cys).
Topics: Alleles; Base Sequence; Brain; Chromosome Mapping; Chromosomes, Human, Pair 11; Cysteine; DNA; DNA Primers; Exons; Genes, Regulator; Genetic Carrier Screening; Homozygote; Humans; Molecular Sequence Data; Point Mutation; Polymerase Chain Reaction; Polymorphism, Genetic; Polymorphism, Restriction Fragment Length; Receptors, Dopamine D2; Schizophrenia; Serine | 1993 |
DRD2 Ser311/Cys311 polymorphism in schizophrenia.
Topics: Cysteine; Female; Humans; Male; Polymerase Chain Reaction; Polymorphism, Genetic; Receptors, Dopamine D2; Schizophrenia; Serine | 1994 |
DRD2 Ser311/Cys311 polymorphism in schizophrenia.
Topics: Cysteine; Humans; Japan; Receptors, Dopamine D2; Schizophrenia; Serine | 1994 |
DRD2 Ser311/Cys311 polymorphism in schizophrenia.
Topics: Cysteine; Humans; Polymorphism, Genetic; Receptors, Dopamine D2; Schizophrenia; Serine | 1994 |
Mismatch PCR RFLP detection of DRD2 Ser311Cys polymorphism and schizophrenia.
Topics: Alleles; Base Sequence; Cysteine; DNA; Female; Genotype; Humans; Japan; Male; Molecular Sequence Data; Polymerase Chain Reaction; Polymorphism, Restriction Fragment Length; Receptors, Dopamine D2; Schizophrenia; Serine | 1994 |
Functional analysis of conserved cysteine residues in the catalytic subunit of the yeast vacuolar H(+)-ATPase.
Topics: Base Sequence; Binding Sites; Cysteine; Ethylmaleimide; Hydrogen-Ion Concentration; Molecular Sequence Data; Mutagenesis, Site-Directed; Nitrates; Proton-Translocating ATPases; Saccharomyces cerevisiae; Sequence Alignment; Serine | 1994 |
The role of cysteine residues in the folding and association of the COOH-terminal propeptide of types I and III procollagen.
Topics: Animals; Cell-Free System; Cysteine; Disulfides; Humans; Mutagenesis, Site-Directed; Procollagen; Protein Folding; Rabbits; Serine | 1994 |
Selective cysteine-->serine replacements in p-hydroxybenzoate hydroxylase from Pseudomonas fluorescens allow the unambiguous assignment of Cys211 as the site of modification by spin-labeled p-chloromercuribenzoate.
Topics: 4-Hydroxybenzoate-3-Monooxygenase; Base Sequence; Catalysis; Chloromercuribenzoates; Cysteine; Electron Spin Resonance Spectroscopy; Kinetics; Molecular Sequence Data; Mutagenesis, Site-Directed; NADP; p-Chloromercuribenzoic Acid; Pseudomonas fluorescens; Serine; Spin Labels; Structure-Activity Relationship | 1994 |
Negative regulation of mitosis in fission yeast by catalytically inactive pyp1 and pyp2 mutants.
Topics: Amino Acid Sequence; Base Sequence; Cloning, Molecular; Cysteine; Escherichia coli; Gene Expression; Mitosis; Molecular Sequence Data; Mutagenesis, Site-Directed; Oligodeoxyribonucleotides; Point Mutation; Protein Tyrosine Phosphatases; Schizosaccharomyces; Serine | 1994 |
The palmitoylation status of the G-protein G(o)1 alpha regulates its activity of interaction with the plasma membrane.
Topics: Adenosine Diphosphate; Animals; Catalysis; Cell Membrane; Cells, Cultured; Chromatography, Gel; Cysteine; Fibroblasts; GTP-Binding Proteins; Hydroxylamine; Hydroxylamines; Immunoblotting; Mutation; Myristic Acid; Myristic Acids; Palmitates; Pertussis Toxin; Precipitin Tests; Rats; Serine; Transfection; Virulence Factors, Bordetella | 1994 |
Mutated forms of the [2Fe-2S] ferredoxin from Clostridium pasteurianum with noncysteinyl ligands to the iron-sulfur cluster.
Topics: Alanine; Base Sequence; Clostridium; Cysteine; DNA, Bacterial; Electron Spin Resonance Spectroscopy; Escherichia coli; Ferredoxins; Iron; Ligands; Molecular Sequence Data; Mutagenesis, Site-Directed; Recombinant Proteins; Serine; Spectrophotometry, Ultraviolet; Spectrum Analysis, Raman; Sulfur | 1994 |
Prolyl 4-hydroxylase: defective assembly of alpha-subunit mutants indicates that assembled alpha-subunits are intramolecularly disulfide bonded.
Topics: Animals; Base Sequence; Cell-Free System; Centrifugation, Density Gradient; Cysteine; Disulfides; Immunosorbent Techniques; Macromolecular Substances; Molecular Sequence Data; Mutagenesis, Site-Directed; Oxidation-Reduction; Procollagen-Proline Dioxygenase; Protein Biosynthesis; Rabbits; Rats; Serine; Structure-Activity Relationship | 1994 |
Histidine ammonia-lyase mutant S143C is posttranslationally converted into fully active wild-type enzyme. Evidence for serine 143 to be the precursor of active site dehydroalanine.
Topics: Alanine; Base Sequence; Cysteine; Histidine Ammonia-Lyase; Kinetics; Molecular Sequence Data; Mutagenesis, Site-Directed; Oxygen; Protein Precursors; Protein Processing, Post-Translational; Pseudomonas putida; Recombinant Proteins; Serine; Structure-Activity Relationship; Sulfhydryl Compounds; Threonine | 1994 |
[Ser77]transforming growth factor-beta 1. Selective biological activity and receptor binding in mink lung epithelial cells.
Topics: Animals; Biological Assay; Cell Line; CHO Cells; Cricetinae; Cysteine; Disulfides; In Vitro Techniques; Mice; Mink; Models, Molecular; Mutagenesis, Site-Directed; Protein Conformation; Receptors, Transforming Growth Factor beta; Recombinant Proteins; Serine; Structure-Activity Relationship; Transforming Growth Factor beta | 1994 |
N-terminally myristoylated Ras proteins require palmitoylation or a polybasic domain for plasma membrane localization.
Topics: Amino Acid Sequence; Animals; Base Sequence; Calcium-Calmodulin-Dependent Protein Kinases; Cell Line; Cell Membrane; Chlorocebus aethiops; Cysteine; DNA Primers; Mitogen-Activated Protein Kinase Kinases; Molecular Sequence Data; Mutagenesis, Site-Directed; Myristic Acid; Myristic Acids; Palmitic Acid; Palmitic Acids; Point Mutation; Polymerase Chain Reaction; Protein Biosynthesis; Protein Kinases; Protein Processing, Post-Translational; Proto-Oncogene Proteins p21(ras); Recombinant Proteins; Restriction Mapping; Sequence Homology, Amino Acid; Serine; Transfection | 1994 |
Characterization of expressed human phenol-sulfating phenol sulfotransferase: effect of mutating cys70 on activity and thermostability.
Topics: Amino Acid Sequence; Animals; Arylsulfotransferase; Base Sequence; Binding Sites; Cloning, Molecular; Cysteine; Humans; Liver; Molecular Sequence Data; Mutagenesis; Sequence Homology, Amino Acid; Serine; Substrate Specificity; Temperature | 1994 |
Monomeric activin A retains high receptor binding affinity but exhibits low biological activity.
Topics: Activin Receptors; Activins; Animals; Baculoviridae; Base Sequence; Binding, Competitive; Cells, Cultured; Cysteine; Follicle Stimulating Hormone; Inhibins; Mice; Molecular Sequence Data; Moths; Mutagenesis, Site-Directed; Pituitary Gland, Anterior; Protein Binding; Protein Conformation; Rats; Receptors, Growth Factor; Recombinant Proteins; Serine | 1994 |
[Properties of glucocorticoid-sensitive alkaline proteinases of rat target organs].
Topics: Animals; Cations, Divalent; Cysteine; Dexamethasone; Edetic Acid; Egtazic Acid; Endopeptidases; Hydrogen-Ion Concentration; Hydrolysis; Liver; Male; Rats; Serine; Thymus Gland | 1993 |
Interaction of mammalian sperm nuclear protamines and peptides derived thereof with immobilized zinc.
Topics: Amino Acid Sequence; Animals; Cell Nucleus; Chromatography, Affinity; Cysteine; Histidine; Humans; Male; Molecular Sequence Data; Peptides; Protamines; Serine; Sheep; Spermatozoa; Swine; Tyrosine; Zinc | 1994 |
Coordination of selenium to molybdenum in formate dehydrogenase H from Escherichia coli.
Topics: Amino Acid Sequence; Conserved Sequence; Cysteine; Electron Spin Resonance Spectroscopy; Escherichia coli; Formate Dehydrogenases; Hydrogenase; Isotope Labeling; Ligands; Metalloproteins; Molecular Sequence Data; Molybdenum; Multienzyme Complexes; Selenium; Selenocysteine; Sequence Homology, Amino Acid; Serine | 1994 |
Mutagenesis of the cyclic AMP receptor protein of Escherichia coli: targeting positions 83, 127 and 128 of the cyclic nucleotide binding pocket.
Topics: Base Sequence; beta-Galactosidase; Binding Sites; Cross-Linking Reagents; Cyclic AMP; Cysteine; Dithionitrobenzoic Acid; Escherichia coli; Glycine; Isoleucine; Molecular Sequence Data; Mutagenesis; Receptors, Cyclic AMP; Serine; Structure-Activity Relationship; Threonine; Transcription, Genetic | 1994 |
Role of individual cysteine residues in the processing and antigenicity of the measles virus haemagglutinin protein.
Topics: Animals; Antibodies, Monoclonal; Cell Line; Cricetinae; Cysteine; Fluorescent Antibody Technique; Hemagglutinins, Viral; Kidney; Measles virus; Mutagenesis, Site-Directed; Plasmids; Recombinant Proteins; Serine; Subcellular Fractions; Transfection | 1994 |
A new substitution, gamma 358 Ser-->Cys, in fibrinogen Milano VII causes defective fibrin polymerization.
Topics: Adult; Albumins; Base Sequence; Cysteine; Electrophoresis, Polyacrylamide Gel; Female; Fibrin; Fibrinogens, Abnormal; Humans; Immunoblotting; Kinetics; Male; Mercaptoethanol; Molecular Sequence Data; Mutation; Pedigree; Polymerase Chain Reaction; Polymers; Sequence Analysis, DNA; Serine | 1994 |
Cysteine to serine replacements in 6-hydroxy-D-nicotine oxidase. Consequences for enzyme activity, cofactor incorporation, and formation of high molecular weight protein complexes with molecular chaperones (GroEL).
Topics: Amino Acid Sequence; Bacterial Proteins; Base Sequence; Chaperonin 60; Chromatography, Gel; Cysteine; DNA Mutational Analysis; Escherichia coli; Flavin-Adenine Dinucleotide; Gene Expression; Heat-Shock Proteins; Molecular Sequence Data; Molecular Weight; Mutagenesis, Site-Directed; Oligodeoxyribonucleotides; Oxidoreductases; Plasmids; Polymerase Chain Reaction; Recombinant Proteins; Serine | 1993 |
Site-directed mutagenesis of human tissue transglutaminase: Cys-277 is essential for transglutaminase activity but not for GTPase activity.
Topics: Binding Sites; Cysteine; Dithiothreitol; Erythrocytes; GTP Phosphohydrolases; Humans; Iodoacetamide; Mutagenesis, Site-Directed; Recombinant Proteins; Serine; Transglutaminases | 1993 |
Product binding to the alpha-carboxyl subsite results in a conformational change at the active site of O-acetylserine sulfhydrylase-A: evidence from fluorescence spectroscopy.
Topics: Acetates; Binding Sites; Circular Dichroism; Cysteine; Cysteine Synthase; Hydrogen-Ion Concentration; Protein Conformation; Pyridoxal Phosphate; Regression Analysis; Salmonella typhimurium; Schiff Bases; Serine; Spectrometry, Fluorescence; Tryptophan | 1994 |
Replacement of the active-site cysteine residues of DsbA, a protein required for disulfide bond formation in vivo.
Topics: Base Sequence; Binding Sites; Circular Dichroism; Cysteine; Disulfides; Dithiothreitol; Electrophoresis, Polyacrylamide Gel; Escherichia coli; Glutathione; Iodoacetamide; Iodoacetates; Iodoacetic Acid; Isomerases; Kinetics; Molecular Sequence Data; Mutagenesis, Site-Directed; Oxidation-Reduction; Polymerase Chain Reaction; Protein Conformation; Protein Disulfide-Isomerases; Serine; Thermodynamics | 1994 |
Lack of N terminal palmitoylation of G protein alpha subunits reduces membrane association.
Topics: Amino Acid Sequence; Animals; Cell Line; Cysteine; Cytosol; DNA, Complementary; GTP-Binding Proteins; Hydroxylamine; Hydroxylamines; Immunoblotting; Molecular Sequence Data; Mutagenesis, Site-Directed; Palmitic Acid; Palmitic Acids; Protein Processing, Post-Translational; Rats; Serine; Transfection | 1993 |
Point mutations of the thyrotropin receptor determining structural requirements for its ability to bind thyrotropin and to stimulate adenylate cyclase activity.
Topics: Adenylyl Cyclases; Adult; Amino Acid Sequence; Animals; Base Sequence; Binding Sites; Binding, Competitive; Cell Line; Cyclic AMP; Cysteine; Gene Library; Genetic Variation; Graves Disease; Humans; Kinetics; Molecular Sequence Data; Mutagenesis, Site-Directed; Oligodeoxyribonucleotides; Point Mutation; Protein Structure, Secondary; Receptors, Thyrotropin; Serine; Thyroid Gland; Thyrotropin; Transfection | 1994 |
Optical, EPR, and 1H NMR spectroscopy of serine-ligated [2Fe-2S] ferredoxins produced by site-directed mutagenesis of cysteine residues in recombinant Anabaena 7120 vegetative ferredoxin.
Topics: Anabaena; Cysteine; Electron Spin Resonance Spectroscopy; Escherichia coli; Ferredoxins; Iron-Sulfur Proteins; Magnetic Resonance Spectroscopy; Mutagenesis, Site-Directed; Plasmids; Recombinant Proteins; Serine; Spectrophotometry; Structure-Activity Relationship | 1994 |
Functional expression of rat alpha 1 Na,K-ATPase containing substitutions for cysteines 454, 458, 459, 513 and 551.
Topics: Adenosine Triphosphate; Alanine; Animals; Blotting, Western; Cysteine; DNA, Complementary; Electrophoresis, Polyacrylamide Gel; HeLa Cells; Humans; Mutagenesis, Site-Directed; Mutation; Ouabain; Rats; Serine; Sodium-Potassium-Exchanging ATPase; Transfection | 1993 |
The alpha/beta subunit interaction in H(+)-ATPase (ATP synthase). An Escherichia coli alpha subunit mutation (Arg-alpha 296-->Cys) restores coupling efficiency to the deleterious beta subunit mutant (Ser-beta 174-->Phe).
Topics: Amino Acid Sequence; Arginine; Biological Transport; Catalysis; Cell Membrane; Cysteine; Escherichia coli; Ethylmaleimide; Hydrogen; Molecular Sequence Data; Mutation; Phenylalanine; Proton-Translocating ATPases; Serine | 1994 |
K-ras-2 topographic genotyping of pancreatic adenocarcinoma.
Topics: Adenocarcinoma; Alanine; Arginine; Aspartic Acid; Codon; Cysteine; DNA, Neoplasm; Exons; Forecasting; Genes, ras; Genotype; Glycine; Humans; Leucine; Mutation; Pancreas; Pancreatic Neoplasms; Serine; Survival Rate; Valine | 1994 |
Characterization of the CysB protein of Klebsiella aerogenes: direct evidence that N-acetylserine rather than O-acetylserine serves as the inducer of the cysteine regulon.
Topics: Amino Acid Sequence; Bacterial Proteins; Base Sequence; Binding Sites; Cloning, Molecular; Cysteine; DNA-Binding Proteins; DNA, Bacterial; Escherichia coli; Klebsiella pneumoniae; Molecular Sequence Data; Regulon; Salmonella typhimurium; Sequence Homology, Amino Acid; Serine | 1994 |
Substrate activation of brewers' yeast pyruvate decarboxylase is abolished by mutation of cysteine 221 to serine.
Topics: Base Sequence; Binding Sites; Cysteine; DNA Primers; Enzyme Activation; Escherichia coli; Kinetics; Molecular Sequence Data; Mutation; Pyruvate Decarboxylase; Recombinant Proteins; Saccharomyces cerevisiae; Serine; Substrate Specificity | 1994 |
Stoichiometry of binding of CysB to the cysJIH, cysK, and cysP promoter regions of Salmonella typhimurium.
Topics: Bacterial Proteins; Cysteine; DNA-Binding Proteins; DNA, Bacterial; Genes, Bacterial; Models, Genetic; Nucleic Acid Conformation; Promoter Regions, Genetic; Protein Binding; Protein Conformation; Regulon; Salmonella typhimurium; Serine; Transcription Factors; Transcription, Genetic | 1994 |
Reducing the heterogeneity of chemically conjugated targeted toxins: homogeneous basic FGF-saporin.
Topics: 3T3 Cells; Animals; Base Sequence; Blotting, Western; Cysteine; Female; Fibroblast Growth Factor 2; Humans; Immunotoxins; Melanoma, Experimental; Mice; Molecular Sequence Data; Mutagenesis, Site-Directed; N-Glycosyl Hydrolases; Ovarian Neoplasms; Plant Proteins; Receptors, Fibroblast Growth Factor; Ribosome Inactivating Proteins, Type 1; Saporins; Serine; Tumor Cells, Cultured | 1993 |
A novel Cys-214-Ser mutation in the peripherin/RDS gene in a Japanese family with autosomal dominant retinitis pigmentosa.
Topics: Age of Onset; Base Sequence; Cysteine; DNA Mutational Analysis; DNA, Single-Stranded; Electrophoresis, Polyacrylamide Gel; Eye Proteins; Genes, Dominant; Humans; Intermediate Filament Proteins; Membrane Glycoproteins; Molecular Sequence Data; Nerve Tissue Proteins; Neuropeptides; Nucleic Acid Conformation; Peripherins; Phenotype; Point Mutation; Polymerase Chain Reaction; Retinitis Pigmentosa; Serine | 1993 |
Crystallization of a DNA and N-acetylserine binding fragment (residues 1 to 233) of Klebsiella aerogenes CysB protein, a member of the LysR family.
Topics: Bacterial Proteins; Crystallography, X-Ray; Cysteine; DNA-Binding Proteins; Helix-Loop-Helix Motifs; Klebsiella pneumoniae; Peptide Fragments; Protein Binding; Serine; Transcription Factors | 1994 |
Identification of residues critical for Ras(17N) growth-inhibitory phenotype and for Ras interaction with guanine nucleotide exchange factors.
Topics: 3T3 Cells; Amino Acid Sequence; Animals; Cell Division; Chloramphenicol O-Acetyltransferase; Cysteine; Gene Expression; GTP-Binding Proteins; Humans; Mice; Molecular Sequence Data; Mutagenesis; Myristic Acid; Myristic Acids; Oncogene Protein p21(ras); Phenotype; Point Mutation; Restriction Mapping; Sequence Homology, Amino Acid; Serine; Transcription, Genetic; Transfection | 1994 |
cys-->ser mutations in ch-human dihydropteridine reductase.
Topics: Amino Acid Sequence; Cloning, Molecular; Cysteine; Dihydropteridine Reductase; Enzyme Stability; Escherichia coli; Humans; Kinetics; Mutagenesis, Site-Directed; Plasmids; Point Mutation; Recombinant Proteins; Serine; Thermodynamics | 1993 |
Autoprocessing of prothiolsubtilisin E in which active-site serine 221 is altered to cysteine.
Topics: Bacillus subtilis; Base Sequence; Binding Sites; Circular Dichroism; Cysteine; DNA Primers; Enzyme Activation; Enzyme Precursors; Molecular Sequence Data; Mutagenesis, Site-Directed; Protein Processing, Post-Translational; Protein Structure, Secondary; Recombinant Proteins; Serine; Structure-Activity Relationship; Subtilisins | 1994 |
Characterization by 1H NMR of a C32S,C35S double mutant of Escherichia coli thioredoxin confirms its resemblance to the reduced wild-type protein.
Topics: Amino Acid Sequence; Binding Sites; Cysteine; Escherichia coli; Hydrogen-Ion Concentration; Magnetic Resonance Spectroscopy; Molecular Sequence Data; Mutation; Protein Conformation; Serine; Thioredoxins | 1994 |
Modification of a free Fe-S cluster cysteine residue in the active iron-responsive element-binding protein prevents RNA binding.
Topics: Amino Acid Sequence; Animals; Cell Line; Cysteine; Cytosol; Deferoxamine; Ethylmaleimide; Fibroblasts; Hemin; Iron-Regulatory Proteins; Iron-Sulfur Proteins; Mice; Polymerase Chain Reaction; Recombinant Proteins; RNA-Binding Proteins; RNA, Messenger; Serine | 1993 |
Mutations of the alpha 2A-adrenergic receptor that eliminate detectable palmitoylation do not perturb receptor-G-protein coupling.
Topics: Acylation; Alanine; Allosteric Regulation; Amino Acid Sequence; Animals; Cell Line; Chromatography, Affinity; Cysteine; Dogs; Electrophoresis, Polyacrylamide Gel; Genetic Vectors; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Guanylyl Imidodiphosphate; Kidney; Kinetics; Mutagenesis, Site-Directed; Palmitic Acid; Palmitic Acids; Receptors, Adrenergic, beta; Recombinant Proteins; Serine; Swine; Transfection; Yohimbine | 1993 |
Site-directed conversion of cysteine-565 to serine in PsaB of photosystem I results in the assembly of [3Fe-4S] and [4Fe-4S] clusters in Fx. A mixed-ligand [4Fe-4S] cluster is capable of electron transfer to FA and FB.
Topics: Amino Acid Sequence; Cyanobacteria; Cysteine; Electron Spin Resonance Spectroscopy; Electron Transport; Iron-Sulfur Proteins; Kinetics; Light; Microwaves; Mutagenesis, Site-Directed; Photosynthetic Reaction Center Complex Proteins; Photosystem I Protein Complex; Protein Conformation; Recombinant Proteins; Serine | 1993 |
Agonist and antagonist profiles of [D-Ala2,Glu4]deltorphin and its [Cys4]- and [Ser4]-substituted derivatives: further evidence of opioid delta receptor multiplicity.
Topics: Amino Acid Sequence; Analgesics; Animals; Brain Chemistry; Cysteine; Enkephalin, Leucine; Male; Mice; Molecular Sequence Data; Oligopeptides; Rats; Receptors, Opioid, delta; Serine | 1993 |
Molecular determinants of the alpha-2D adrenergic receptor subtype.
Topics: Amino Acid Sequence; Animals; Base Sequence; Cattle; Chickens; Cysteine; Mice; Molecular Sequence Data; Rats; Receptors, Adrenergic, alpha-2; Sequence Homology, Amino Acid; Sequence Homology, Nucleic Acid; Serine; Structure-Activity Relationship | 1993 |
Palmitoylation of bovine opsin and its cysteine mutants in COS cells.
Topics: Amino Acid Sequence; Animals; Cattle; Cell Line; Cell Membrane; Cysteine; Electrophoresis, Polyacrylamide Gel; Eye Proteins; G-Protein-Coupled Receptor Kinase 1; Molecular Sequence Data; Mutagenesis, Site-Directed; Palmitic Acid; Palmitic Acids; Phosphorylation; Protein Kinases; Protein Processing, Post-Translational; Protein Structure, Secondary; Recombinant Proteins; Rhodopsin; Rod Opsins; Serine; Spectrophotometry; Transfection | 1993 |
Pharmacological basis of contractile effects of peptidoleukotrienes on rabbit colonic muscularis mucosae.
Topics: Animals; Borates; Colon; Cysteine; Gastrointestinal Motility; Indomethacin; Leukotrienes; Male; Muscle, Smooth; Peptides; Prostaglandins; Rabbits; Serine; Sulfides | 1993 |
Catalytic properties and stability of a Pseudomonas sp.101 formate dehydrogenase mutants containing Cys-255-Ser and Cys-255-Met replacements.
Topics: Amino Acid Sequence; Base Sequence; Catalysis; Cysteine; Dithionitrobenzoic Acid; Enzyme Stability; Formate Dehydrogenases; Kinetics; Mercury; Methionine; Molecular Sequence Data; Mutation; Oligonucleotides; Pseudomonas; Sequence Homology, Amino Acid; Serine | 1993 |
Muscle-specific calpain, p94, is degraded by autolysis immediately after translation, resulting in disappearance from muscle.
Topics: Amino Acid Sequence; Animals; Base Sequence; Calpain; Cell Line; Chlorocebus aethiops; Cysteine; Immunohistochemistry; Kidney; Macromolecular Substances; Molecular Sequence Data; Molecular Weight; Muscles; Mutagenesis, Site-Directed; Oligodeoxyribonucleotides; Protein Biosynthesis; Rats; Recombinant Proteins; RNA, Messenger; Sequence Deletion; Serine; Transfection | 1993 |
Gene-environment interaction in the conversion of a mild-to-severe phenotype in a patient homozygous for a Ser172-->Cys mutation in the lipoprotein lipase gene.
Topics: Adult; Amino Acid Sequence; Animals; Base Sequence; Cell Line; Chlorocebus aethiops; Cysteine; DNA; Exons; Female; Gene Conversion; Homozygote; Humans; Leukocytes; Lipoprotein Lipase; Liver; Molecular Sequence Data; Mutagenesis, Site-Directed; Oligodeoxyribonucleotides; Phenotype; Point Mutation; Pregnancy; Pregnancy Complications; Serine; Transfection; Triglycerides | 1993 |
A dramatic change in the rate-limiting step of beta-lactam hydrolysis results from the substitution of the active-site serine residue by a cysteine in the class-C beta-lactamase of Enterobacter cloacae 908R.
Topics: Anti-Bacterial Agents; Base Sequence; beta-Lactamase Inhibitors; beta-Lactamases; beta-Lactams; Binding Sites; Cysteine; Enterobacter cloacae; Hydrogen-Ion Concentration; Hydrolysis; Kinetics; Molecular Sequence Data; Mutagenesis, Site-Directed; Oligodeoxyribonucleotides; Serine | 1993 |
A ligand-induced conformational change in the Yersinia protein tyrosine phosphatase.
Topics: Amino Acid Sequence; Aspartic Acid; Binding Sites; Crystallization; Crystallography, X-Ray; Cysteine; Models, Molecular; Molecular Sequence Data; Mutation; Protein Conformation; Protein Tyrosine Phosphatases; Serine; Sulfates; Tungsten Compounds; Water; Yersinia | 1995 |
High-level expression of fully active human glutaredoxin (thioltransferase) in E. coli and characterization of Cys7 to Ser mutant protein.
Topics: Amino Acid Sequence; Base Sequence; Cysteine; Escherichia coli; Gene Expression; Genetic Vectors; Glutaredoxins; Humans; Macromolecular Substances; Molecular Sequence Data; Mutagenesis, Site-Directed; Oxidation-Reduction; Oxidoreductases; Proteins; Recombinant Proteins; Serine; Structure-Activity Relationship; Transfection | 1996 |
Amino-acid-type-selective triple-resonance experiments.
Topics: Alanine; Amino Acid Sequence; Amino Acids; Asparagine; Aspartic Acid; Calcium-Binding Proteins; Carbon; Carrier Proteins; Cysteine; Glycine; Image Enhancement; Isoleucine; Magnetic Resonance Spectroscopy; Methionine; Microfilament Proteins; Nitrogen; Serine; Valine | 1996 |
Biochemical and biophysical comparison of native and chemically synthesized phospholamban and a monomeric phospholamban analog.
Topics: Adenosine Triphosphatases; Amino Acid Sequence; Animals; Antibodies, Monoclonal; Blotting, Western; Calcium-Binding Proteins; Chromatography, Affinity; Chromatography, High Pressure Liquid; Circular Dichroism; Cyanogen Bromide; Cysteine; Dogs; Electrophoresis, Polyacrylamide Gel; Macromolecular Substances; Molecular Sequence Data; Myocardium; Peptide Fragments; Peptide Mapping; Protein Structure, Secondary; Sarcoplasmic Reticulum; Serine; Structure-Activity Relationship | 1996 |
Cartilage matrix protein forms a type II collagen-independent filamentous network: analysis in primary cell cultures with a retrovirus expression system.
Topics: Amino Acid Sequence; Animals; Base Sequence; Cartilage; Cells, Cultured; Chick Embryo; Collagen; Cysteine; DNA Primers; Extracellular Matrix Proteins; Fibroblasts; Genetic Vectors; Glycoproteins; Matrilin Proteins; Models, Biological; Molecular Sequence Data; Mutagenesis, Site-Directed; Point Mutation; Polymerase Chain Reaction; Recombinant Proteins; Retroviridae; Serine; Transfection | 1995 |
The role of arsenic-thiol interactions in metalloregulation of the ars operon.
Topics: Amino Acid Sequence; Antimony; Arsenicals; Arsenites; Bacterial Proteins; Base Sequence; Cysteine; Drug Resistance, Microbial; Escherichia coli; Escherichia coli Proteins; Gene Expression Regulation, Bacterial; Helix-Turn-Helix Motifs; Kinetics; Models, Structural; Molecular Sequence Data; Mutagenesis, Site-Directed; Oligodeoxyribonucleotides; Operon; Protein Structure, Secondary; R Factors; Repressor Proteins; Sequence Homology, Amino Acid; Serine; Trans-Activators | 1996 |
Topological mapping of the cysteine residues of N-carbamyl-D-amino-acid amidohydrolase and their role in enzymatic activity.
Topics: Alanine; Amidohydrolases; Amino Acid Sequence; Base Sequence; Chromatography, High Pressure Liquid; Cysteine; DNA Primers; Genes, Bacterial; Iodoacetates; Iodoacetic Acid; Kinetics; Molecular Sequence Data; Mutagenesis, Site-Directed; Peptide Fragments; Plasmids; Point Mutation; Recombinant Proteins; Restriction Mapping; Rhizobium; Serine | 1996 |
Glycoprotein B of herpes simplex virus type 1 oligomerizes through the intermolecular interaction of a 28-amino-acid domain.
Topics: Amino Acid Sequence; Animals; Binding Sites; Chlorocebus aethiops; Cysteine; Disulfides; Herpesvirus 1, Human; Humans; Molecular Sequence Data; Mutagenesis, Site-Directed; Oligopeptides; Protein Processing, Post-Translational; Protein Structure, Secondary; Serine; Vero Cells; Viral Envelope Proteins | 1996 |
Protease activity of in vitro transcribed and translated Caenorhabditis elegans cell death gene (ced-3) product.
Topics: Amino Acid Sequence; Animals; Apoptosis; Aurintricarboxylic Acid; Base Sequence; Binding Sites; Caenorhabditis elegans; Caenorhabditis elegans Proteins; Caspase 1; Caspases; Cysteine; Cysteine Endopeptidases; DNA Primers; Helminth Proteins; Kinetics; Mammals; Molecular Sequence Data; Mutagenesis, Site-Directed; Point Mutation; Polymerase Chain Reaction; Protein Biosynthesis; Recombinant Proteins; Serine; Transcription, Genetic | 1996 |
A novel Ser156Cys mutation in the tissue inhibitor of metalloproteinases-3 (TIMP3) in Sorsby's fundus dystrophy with unusual clinical features.
Topics: Amino Acid Sequence; Base Sequence; Cysteine; DNA; Female; Humans; Macular Degeneration; Male; Molecular Sequence Data; Mutation; Pedigree; Proteins; Serine; Tissue Inhibitor of Metalloproteinase-3 | 1995 |
The rate of thermal inactivation of Torpedo acetylcholinesterase is not reduced in the C231S mutant.
Topics: Acetylcholinesterase; Animals; Cell Line; Chlorocebus aethiops; Cholinesterase Inhibitors; Cysteine; Dithionitrobenzoic Acid; Hot Temperature; Kinetics; Mutagenesis, Site-Directed; Point Mutation; Recombinant Proteins; Serine; Sulfhydryl Reagents; Thermodynamics; Torpedo; Transfection | 1996 |
Sorsby fundus dystrophy. A family with the Ser181Cys mutation of the tissue inhibitor of metalloproteinases 3.
Topics: Adult; Aged; Chromosomes, Human, Pair 22; Cysteine; DNA; Female; Fundus Oculi; Humans; Macula Lutea; Macular Degeneration; Male; Microsatellite Repeats; Middle Aged; Pedigree; Point Mutation; Proteins; Serine; Tissue Inhibitor of Metalloproteinase-3 | 1996 |
Three-dimensional structure of the reduced C77S mutant of the Chromatium vinosum high-potential iron-sulfur protein through nuclear magnetic resonance: comparison with the solution structure of the wild-type protein.
Topics: Amino Acid Sequence; Bacterial Proteins; Chromatium; Cysteine; Iron-Sulfur Proteins; Magnetic Resonance Spectroscopy; Models, Molecular; Molecular Sequence Data; Molecular Structure; Oxidation-Reduction; Photosynthetic Reaction Center Complex Proteins; Point Mutation; Protein Conformation; Protons; Serine; Solutions; Thermodynamics | 1996 |
Halolysin R4, a serine proteinase from the halophilic archaeon Haloferax mediterranei; gene cloning, expression and structural studies.
Topics: Amino Acid Sequence; Archaea; Base Sequence; Cloning, Molecular; Cysteine; DNA Primers; Genes, Bacterial; Hot Temperature; Kinetics; Molecular Sequence Data; Mutagenesis, Site-Directed; Oligonucleotide Probes; Plasmids; Point Mutation; Polymerase Chain Reaction; Recombinant Proteins; Restriction Mapping; Sequence Homology, Amino Acid; Serine; Serine Endopeptidases; Sodium Chloride | 1996 |
Assembly and secretion of fibrinogen. Involvement of amino-terminal domains in dimer formation.
Topics: Animals; Base Sequence; Cell Line; Cysteine; Electrophoresis, Gel, Two-Dimensional; Fibrinogen; Molecular Sequence Data; Mutagenesis, Site-Directed; Sequence Deletion; Serine | 1996 |
Analysis of the structural properties of cAMP-responsive element-binding protein (CREB) and phosphorylated CREB.
Topics: Amino Acid Sequence; Animals; Base Sequence; Binding Sites; Biophysical Phenomena; Biophysics; Circular Dichroism; Cyclic AMP Response Element-Binding Protein; Cyclic AMP-Dependent Protein Kinases; Cysteine; DNA; In Vitro Techniques; Molecular Sequence Data; Molecular Structure; Phosphorylation; Protein Engineering; Protein Structure, Secondary; Rats; Serine | 1996 |
A conserved cysteine residue in the runt homology domain of AML1 is required for the DNA binding ability and the transforming activity on fibroblasts.
Topics: 3T3 Cells; Animals; Cell Line; Cell Transformation, Neoplastic; Conserved Sequence; Core Binding Factor Alpha 2 Subunit; Cysteine; Diamide; DNA-Binding Proteins; Ethylmaleimide; Fibroblasts; Mice; Mutagenesis, Site-Directed; Neoplasm Proteins; Oxidation-Reduction; Protein Binding; Proto-Oncogene Proteins; Serine; Transcription Factor AP-2; Transcription Factors; Transcriptional Activation | 1996 |
Differentiation of catalytic sites on Escherichia coli F1ATPase by laser photoactivated labeling with [3H]-2-Azido-ATP using the mutant beta Glu381Cys:epsilonSer108Cys to identify different beta subunits by their interactions with gamma and epsilon subuni
Topics: Adenosine Triphosphate; Affinity Labels; Azides; Cysteine; Edetic Acid; Escherichia coli; Glutamic Acid; Kinetics; Macromolecular Substances; Magnesium; Mutagenesis, Site-Directed; Photolysis; Point Mutation; Protein Binding; Proton-Translocating ATPases; Recombinant Proteins; Serine; Spectrometry, Fluorescence; Tritium | 1996 |
No association of the structural dopamine D2 receptor (DRD2) variant 311Cys with alcoholism.
Topics: Adult; Alcoholism; Alleles; Cysteine; DNA Mutational Analysis; Female; Gene Frequency; Genetic Variation; Humans; Male; Middle Aged; Polymerase Chain Reaction; Polymorphism, Genetic; Polymorphism, Restriction Fragment Length; Receptors, Dopamine D2; Serine | 1996 |
Mutational analysis of two zinc finger motifs in HIV type 1 nucleocapsid proteins: effects on proteolytic processing of Gag precursors and particle formation.
Topics: Amino Acid Sequence; Animals; Base Sequence; Capsid; Cell Line, Transformed; Chlorocebus aethiops; Cysteine; DNA, Viral; Gene Products, gag; HIV-1; Humans; Molecular Sequence Data; Morphogenesis; Mutagenesis, Site-Directed; Proviruses; RNA, Viral; Serine; Structure-Activity Relationship; T-Lymphocytes; Transfection; Virion; Zinc Fingers | 1996 |
Intermolecular disulfide bonds stabilize VirB7 homodimers and VirB7/VirB9 heterodimers during biogenesis of the Agrobacterium tumefaciens T-complex transport apparatus.
Topics: Agrobacterium tumefaciens; Amino Acid Sequence; Bacterial Proteins; Base Sequence; Biological Transport; Cysteine; Disulfides; DNA-Binding Proteins; DNA, Bacterial; Ion Channels; Macromolecular Substances; Membrane Proteins; Molecular Sequence Data; Molecular Weight; Mutagenesis, Site-Directed; Protein Multimerization; Recombinant Proteins; Serine; Virulence Factors | 1996 |
Human ferredoxin: overproduction in Escherichia coli, reconstitution in vitro, and spectroscopic studies of iron-sulfur cluster ligand cysteine-to-serine mutants.
Topics: Amino Acid Sequence; Anabaena; Cysteine; Electron Spin Resonance Spectroscopy; Escherichia coli; Ferredoxins; Gene Expression; Humans; Molecular Sequence Data; Mutagenesis, Site-Directed; Protein Structure, Secondary; Recombinant Proteins; Sequence Alignment; Serine; Spectrophotometry; Spectrophotometry, Ultraviolet | 1996 |
Conversion of serine-114 to cysteine-114 and the role of the active site nucleophile in acyl transfer by myristoyl-ACP thioesterase from Vibrio harveyi.
Topics: Acylation; Acyltransferases; Amino Acid Sequence; Animals; Bacterial Proteins; Binding Sites; Consensus Sequence; Crystallography, X-Ray; Cysteine; Kinetics; Models, Molecular; Molecular Sequence Data; Multigene Family; Mutagenesis, Site-Directed; Point Mutation; Recombinant Proteins; Sequence Homology, Amino Acid; Serine; Thiolester Hydrolases; Vibrio | 1996 |
Crystal structures of reduced, oxidized, and mutated human thioredoxins: evidence for a regulatory homodimer.
Topics: Amino Acid Sequence; Binding Sites; Crystallization; Crystallography, X-Ray; Cysteine; Disulfides; Dithiothreitol; Humans; Hydrogen Bonding; Models, Molecular; Molecular Sequence Data; Mutation; Oxidation-Reduction; Protein Conformation; Protein Structure, Secondary; Protein Structure, Tertiary; Sequence Alignment; Serine; Software; Thioredoxins | 1996 |
Negative regulation of Raf-1 by phosphorylation of serine 621.
Topics: Alanine; Amino Acid Sequence; Animals; Binding Sites; Blotting, Western; Chlorocebus aethiops; Cloning, Molecular; Consensus Sequence; COS Cells; Cysteine; Homeostasis; Humans; Molecular Sequence Data; Mutagenesis, Site-Directed; Peptide Fragments; Peptide Mapping; Phosphorylation; Point Mutation; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-raf; Recombinant Proteins; Serine; Transfection | 1996 |
No evidence for association of dopamine D2 receptor variant (Ser311/Cys311) with major psychosis.
Topics: Adult; Age of Onset; Amino Acid Sequence; Bipolar Disorder; Cysteine; Delusions; Female; Genetic Variation; Humans; Male; Middle Aged; Psychotic Disorders; Receptors, Dopamine D2; Reference Values; Schizophrenia; Serine; White People | 1996 |
Site-directed mutagenesis of cysteinyl and serine residues of human thromboxane A2 receptor in insect cells.
Topics: Amino Acid Sequence; Animals; Baculoviridae; Base Sequence; Binding Sites; Bridged Bicyclo Compounds, Heterocyclic; Cell Line; Cloning, Molecular; Cysteine; Disulfides; DNA Primers; DNA, Complementary; Fatty Acids, Unsaturated; Humans; Hydrazines; Hydrogen Bonding; Kinetics; Ligands; Models, Molecular; Molecular Sequence Data; Mutagenesis, Site-Directed; Point Mutation; Polymerase Chain Reaction; Receptors, Thromboxane; Recombinant Proteins; Sequence Homology, Amino Acid; Serine; Spodoptera | 1996 |
In vitro characterization of constitutive CysB proteins from Salmonella typhimurium.
Topics: Alleles; Bacterial Proteins; Base Sequence; Binding Sites; Cysteine; DNA, Bacterial; Escherichia coli; Kinetics; Nucleic Acid Conformation; Point Mutation; Promoter Regions, Genetic; Protein Conformation; Regulon; Salmonella typhimurium; Serine; Thiosulfates; Trans-Activators; Transcriptional Activation | 1996 |
Dopamine DRD2/Cys311 is not associated with chronic schizophrenia.
Topics: Asian People; Base Sequence; Codon; Cysteine; DNA Primers; Gene Frequency; Genetic Variation; Humans; Japan; Point Mutation; Polymerase Chain Reaction; Receptors, Dopamine D2; Schizophrenia; Serine; United States; White People | 1996 |
Cha4p of Saccharomyces cerevisiae activates transcription via serine/threonine response elements.
Topics: Alleles; Amino Acid Sequence; Base Sequence; Cloning, Molecular; Cysteine; DNA-Binding Proteins; DNA, Fungal; Gene Expression Regulation, Fungal; Molecular Sequence Data; Mutagenesis; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Sequence Homology, Amino Acid; Serine; Threonine; Trans-Activators; Transcriptional Activation; Zinc Fingers | 1996 |
The role of individual cysteine residues in the processing, structure, and function of human macrophage colony-stimulating factor.
Topics: 3T3 Cells; Amino Acid Sequence; Animals; Antibodies; Cell Division; Cell Line; Cell Survival; Cysteine; Dimerization; Humans; Immunoblotting; Macrophage Colony-Stimulating Factor; Macrophages; Mice; Mutagenesis, Site-Directed; Point Mutation; Recombinant Proteins; Serine; Transfection | 1996 |
Clozapine response and the 5HT2C Cys23Ser polymorphism.
Topics: Alleles; Antipsychotic Agents; Base Sequence; Clozapine; Cysteine; DNA Primers; Female; Genetic Carrier Screening; Homozygote; Humans; Male; Polymerase Chain Reaction; Polymorphism, Restriction Fragment Length; Predictive Value of Tests; Psychotic Disorders; Receptor, Serotonin, 5-HT2C; Receptors, Serotonin; Schizophrenia; Serine | 1996 |
Identification of an active site cysteine residue in human type I Ins(1,4,5)P3 5-phosphatase by chemical modification and site-directed mutagenesis.
Topics: Alanine; Amino Acid Sequence; Animals; Binding Sites; Cattle; Circular Dichroism; Cysteine; Enzyme Inhibitors; Humans; Indicators and Reagents; Inositol Polyphosphate 5-Phosphatases; Molecular Sequence Data; Mutagenesis, Site-Directed; Phosphoric Monoester Hydrolases; Sequence Alignment; Serine; Substrate Specificity; Sulfhydryl Compounds | 1996 |
Production and comparison of mature single-domain 'trefoil' peptides pNR-2/pS2 Cys58 and pNR-2/pS2 Ser58.
Topics: Amino Acid Sequence; Blotting, Western; Breast Neoplasms; Chromatography, Gel; Chromatography, Ion Exchange; Cysteine; Dithiothreitol; Electrophoresis, Polyacrylamide Gel; Glutathione; Humans; Molecular Sequence Data; Molecular Weight; Mutagenesis, Site-Directed; Mutation; Neoplasm Proteins; Peptides; Plasmids; Polymerase Chain Reaction; Proteins; Recombinant Proteins; Serine; Trefoil Factor-1; Tumor Suppressor Proteins | 1995 |
Site-directed mutagenesis of cysteinyl residues in aspartase of Escherichia coli.
Topics: Aspartate Ammonia-Lyase; Bacterial Proteins; Cysteine; Escherichia coli; Kinetics; Mutagenesis, Site-Directed; Serine | 1996 |
Protein engineering of a cephalosporin C acylase.
Topics: Amidohydrolases; Bioreactors; Chloromercuribenzoates; Cysteine; Enzyme Inhibitors; Enzymes, Immobilized; Kinetics; Mutagenesis, Site-Directed; p-Chloromercuribenzoic Acid; Penicillin Amidase; Protein Engineering; Pseudomonas; Serine; Structure-Activity Relationship; Sulfhydryl Reagents | 1996 |
Transfection with human thioredoxin increases cell proliferation and a dominant-negative mutant thioredoxin reverses the transformed phenotype of human breast cancer cells.
Topics: 3T3 Cells; Animals; Breast Neoplasms; Cell Division; Cell Transformation, Neoplastic; Cysteine; Genetic Vectors; Humans; Mice; Mutation; Neoplasm Proteins; Peptide Fragments; Phenotype; Serine; Thioredoxins; Transfection; Tumor Cells, Cultured | 1996 |
Compound heterozygosity for a known and a novel defect in the lipoprotein lipase gene (Asp250-->Asn; Ser251-->Cys) resulting in lipoprotein lipase (LPL) deficiency.
Topics: Adolescent; Asparagine; Aspartic Acid; Cysteine; Denmark; DNA; Heterozygote; Humans; Hyperlipoproteinemia Type I; Hypertriglyceridemia; Lipoprotein Lipase; Male; Mutagenesis, Site-Directed; Point Mutation; Polymerase Chain Reaction; Serine | 1996 |
Small molecule interactions with protein-tyrosine phosphatase PTP1B and their use in inhibitor design.
Topics: Binding Sites; Calorimetry; Computer Simulation; Crystallography, X-Ray; Cysteine; Drug Design; Enzyme Inhibitors; Kinetics; Models, Molecular; Naphthalenes; Organophosphonates; Phosphotyrosine; Point Mutation; Protein Conformation; Protein Structure, Secondary; Protein Tyrosine Phosphatases; Recombinant Proteins; Serine | 1996 |
Energetics of nucleophile activation in a protein tyrosine phosphatase.
Topics: Computer Simulation; Crystallography, X-Ray; Cysteine; Hydrogen Bonding; Hydrogen-Ion Concentration; Models, Chemical; Oxygen; Phosphates; Protein Conformation; Protein Tyrosine Phosphatases; Protons; Serine; Thermodynamics | 1997 |
Methionine and cysteine metabolism in Fasciola hepatica.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Abattoirs; Animals; Cystathionine beta-Synthase; Cystathionine gamma-Lyase; Cysteine; Fasciola hepatica; Homocysteine S-Methyltransferase; Methionine; Methyltransferases; Radioisotope Dilution Technique; Serine; Sulfur Radioisotopes | 1996 |
5-HT2C (HTR2C) serotonin receptor gene polymorphism associated with the human personality trait of reward dependence: interaction with dopamine D4 receptor (D4DR) and dopamine D3 receptor (D3DR) polymorphisms.
Topics: Adult; Cohort Studies; Cysteine; DNA Primers; Exploratory Behavior; Female; Genetic Markers; Genotype; Humans; Israel; Male; Polymerase Chain Reaction; Polymorphism, Genetic; Receptor, Serotonin, 5-HT2C; Receptors, Dopamine D2; Receptors, Dopamine D3; Receptors, Dopamine D4; Receptors, Serotonin; Reward; Serine; Surveys and Questionnaires; Temperament | 1997 |
Mutations in the COL5A1 gene are causal in the Ehlers-Danlos syndromes I and II.
Topics: Adolescent; Adult; Amino Acid Sequence; Animals; Cells, Cultured; Collagen; Conserved Sequence; Cysteine; Ehlers-Danlos Syndrome; Female; Genetic Linkage; Humans; Male; Molecular Sequence Data; Mutation; Pedigree; Procollagen; Serine; Skin | 1997 |
Roles of disulfide bonds in bacterial alkaline phosphatase.
Topics: Alkaline Phosphatase; Bacterial Proteins; Binding Sites; Cysteine; Disulfides; Mutagenesis, Site-Directed; Protein Conformation; Protein Denaturation; Protein Folding; Serine; Structure-Activity Relationship; Trypsin | 1997 |
Autophosphorylation-inactivation site of hexokinase 2 in Saccharomyces cerevisiae.
Topics: Alanine; Cysteine; Hexokinase; Phosphorylation; Point Mutation; Saccharomyces cerevisiae; Serine | 1997 |
Serine319 and 321 are functional in isocitrate lyase from Escherichia coli.
Topics: Alanine; Asparagine; Cysteine; Electrophoresis, Polyacrylamide Gel; Escherichia coli; Gene Expression Regulation, Bacterial; Glycine; Histidine; Isocitrate Lyase; Isocitrates; Kinetics; Magnesium; Mutagenesis, Site-Directed; Oligonucleotides; Plasmids; Proline; Sequence Alignment; Serine; Threonine | 1997 |
The single sulfur to oxygen substitution in the active site nucleophile of the Yersinia protein-tyrosine phosphatase leads to substantial structural and functional perturbations.
Topics: Binding Sites; Circular Dichroism; Cysteine; Mutagenesis, Site-Directed; Oxygen; Polymerase Chain Reaction; Protein Conformation; Protein Tyrosine Phosphatases; Serine; Spectrometry, Fluorescence; Spectrophotometry, Ultraviolet; Structure-Activity Relationship; Sulfur; Yersinia enterocolitica | 1997 |
Differential in vivo roles played by DsbA and DsbC in the formation of protein disulfide bonds.
Topics: Alkaline Phosphatase; Cysteine; Disulfides; Escherichia coli; Genes, Bacterial; Glutathione; Glutathione Disulfide; Isoenzymes; Isomerases; Mutagenesis, Site-Directed; Point Mutation; Protein Disulfide-Isomerases; Recombinant Proteins; Serine | 1997 |
Role of the disulfide bond in Shiga toxin A-chain for toxin entry into cells.
Topics: Amino Acid Sequence; Bacterial Toxins; Biological Transport; Brefeldin A; Cyclopentanes; Cysteine; Cytotoxins; Disulfides; Dose-Response Relationship, Drug; Female; Golgi Apparatus; Humans; Molecular Sequence Data; Mutagenesis, Site-Directed; Point Mutation; Protein Conformation; Protein Processing, Post-Translational; Serine; Shiga Toxins; Toxicity Tests; Tumor Cells, Cultured | 1997 |
The gamma subunit of rod cGMP-phosphodiesterase blocks the enzyme catalytic site.
Topics: 3',5'-Cyclic-GMP Phosphodiesterases; Animals; Binding Sites; Cattle; Cell Membrane; Coumarins; Cyclic GMP; Cysteine; Fluorescent Dyes; Kinetics; Macromolecular Substances; Phosphodiesterase Inhibitors; Point Mutation; Purinones; Rod Cell Outer Segment; Serine; Vertebrates | 1997 |
Mutagenesis of firefly luciferase shows that cysteine residues are not required for bioluminescence activity.
Topics: Animals; Coleoptera; Cysteine; Enzyme Inhibitors; Kinetics; Luciferases; Luminescence; Mutagenesis, Site-Directed; Recombinant Proteins; Serine; Species Specificity; Tosylphenylalanyl Chloromethyl Ketone | 1997 |
Site-directed mutagenesis of the cysteine residues in the Pichia stipitis xylose reductase.
Topics: 4-Chloromercuribenzenesulfonate; Aldehyde Reductase; Binding Sites; Cloning, Molecular; Coenzymes; Cysteine; Enzyme Inhibitors; Mutagenesis, Site-Directed; NAD; NADP; Pichia; Plasmids; Polymerase Chain Reaction; Recombinant Proteins; Recombination, Genetic; Serine; Xylose | 1997 |
Antagonist binding characteristics of the Ser311-->Cys variant of human dopamine D2 receptor in vivo and in vitro.
Topics: Adult; Aged; Aged, 80 and over; Animals; CHO Cells; Cricetinae; Cysteine; Dopamine Antagonists; Dopamine D2 Receptor Antagonists; Female; Heterozygote; Humans; Male; Middle Aged; Protein Binding; Raclopride; Radioligand Assay; Receptors, Dopamine D2; Salicylamides; Serine; Spiperone | 1997 |
The conserved residue tyrosine 34 is essential for maximal activity of iron-superoxide dismutase from Escherichia coli.
Topics: Amino Acid Sequence; Conserved Sequence; Cysteine; Escherichia coli; Hydrogen-Ion Concentration; Models, Molecular; Mutagenesis, Site-Directed; Phenylalanine; Restriction Mapping; Serine; Structure-Activity Relationship; Superoxide Dismutase; Tyrosine | 1997 |
High-affinity binding of bioactive glycosylation-inhibiting factor to antigen-primed T cells and natural killer cells.
Topics: Alanine; Animals; Asparagine; Binding Sites; Cell Line; Cysteine; Escherichia coli; Humans; Hybridomas; Killer Cells, Natural; Kinetics; Lymphocyte Activation; Lymphokines; Macrophages; Mice; Mice, Inbred BALB C; Mutagenesis, Site-Directed; Point Mutation; Prostatic Secretory Proteins; Recombinant Proteins; Serine; Suppressor Factors, Immunologic; T-Lymphocytes, Regulatory; Tumor Necrosis Factor-alpha | 1997 |
Benzyloxycarbonylprolylprolinal, a transition-state analogue for prolyl oligopeptidase, forms a tetrahedral adduct with catalytic serine, not a reactive cysteine.
Topics: Cysteine; Dipeptides; Magnetic Resonance Spectroscopy; Prolyl Oligopeptidases; Serine; Serine Endopeptidases | 1997 |
The disulfide bond in the Aeromonas hydrophila lipase/acyltransferase stabilizes the structure but is not required for secretion or activity.
Topics: Acyltransferases; Aeromonas hydrophila; Bacterial Toxins; Cysteine; Disulfides; Enzyme Stability; Hydrolysis; Mutagenesis, Site-Directed; Pore Forming Cytotoxic Proteins; Serine; Structure-Activity Relationship; Trypsin | 1997 |
Effect of mutations at Cys237 on the activation state and activity of human phenylalanine hydroxylase.
Topics: Aspartic Acid; Chemical Phenomena; Chemistry, Physical; Cysteine; Enzyme Activation; Enzyme Stability; Humans; Hydrogen-Ion Concentration; Kinetics; Mutagenesis, Site-Directed; Phenylalanine Hydroxylase; Serine; Spectrometry, Fluorescence | 1997 |
Inhibition of octapeptide N-myristoylation by acyl amino acids and acyl alkanolamines.
Topics: Acylation; Acyltransferases; Amino Acids; Amino Alcohols; Anti-HIV Agents; Cell Line; Coenzyme A Ligases; Cysteine; Fatty Acids; HIV-1; Kinetics; Myristates; Oligopeptides; Serine | 1997 |
Lysine deficiency in postweaned calves fed corn and corn gluten meal diets.
Topics: Aging; Analysis of Variance; Animals; Arginine; Caseins; Cattle; Cattle Diseases; Cysteine; Deficiency Diseases; Diet; Glutamine; Glutens; Glycine; Lysine; Male; Methionine; Nitrogen; Rumen; Serine; Threonine; Zea mays | 1997 |
Disulfide bond formation is not involved in cap-binding activity of Xenopus translation initiation factor eIF-4E.
Topics: Amino Acid Sequence; Animals; Cysteine; Disulfides; Escherichia coli; Eukaryotic Initiation Factor-4E; Genetic Vectors; Humans; Mice; Molecular Sequence Data; Mutagenesis, Site-Directed; Peptide Initiation Factors; Rabbits; Serine; Xenopus | 1997 |
The role of cysteine residues in the homeodomain protein Mat alpha 2 in mating-type control of Saccharomyces cerevisiae.
Topics: Cysteine; Dimerization; Fungal Proteins; Homeodomain Proteins; Mutation; Receptors, Mating Factor; Receptors, Peptide; Repressor Proteins; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Serine; Sulfides; Transcription Factors; Transformation, Genetic; Tyrosine | 1997 |
Posttranslational modification of oat phytochrome A: phosphorylation of a specific serine in a multiple serine cluster.
Topics: Amino Acid Sequence; Avena; Cysteine; Molecular Sequence Data; Phosphopeptides; Phosphorylation; Phosphoserine; Phytochrome; Phytochrome A; Protein Processing, Post-Translational; Sequence Analysis; Sequence Homology, Amino Acid; Serine; Spectrometry, Mass, Fast Atom Bombardment; Trypsin | 1997 |
A cysteine-3 to serine mutation of the G-protein Gi1 alpha abrogates functional activation by the alpha 2A-adrenoceptor but not interactions with the beta gamma complex.
Topics: Adenylate Cyclase Toxin; Adenylyl Cyclases; Animals; Chlorocebus aethiops; COS Cells; Cysteine; GTP-Binding Protein alpha Subunits, Gi-Go; Mutagenesis, Site-Directed; Palmitic Acid; Pertussis Toxin; Receptors, Adrenergic, alpha-2; Serine; Virulence Factors, Bordetella | 1997 |
Alcoholism and gene polymorphisms related to central dopaminergic transmission in the Japanese population.
Topics: Alcoholism; Amino Acid Sequence; Carrier Proteins; Cysteine; Dopamine; Dopamine Plasma Membrane Transport Proteins; Genotype; Humans; Japan; Membrane Glycoproteins; Membrane Transport Proteins; Nerve Tissue Proteins; Polymerase Chain Reaction; Polymorphism, Genetic; Receptors, Dopamine D2; Receptors, Dopamine D3; Reference Values; Repetitive Sequences, Nucleic Acid; Restriction Mapping; Serine | 1997 |
Analysis of sequence requirements for biological activity of cyanovirin-N, a potent HIV (human immunodeficiency virus)-inactivating protein.
Topics: Amino Acid Sequence; Anti-HIV Agents; Bacterial Proteins; Carrier Proteins; Cysteine; Disulfides; HIV Envelope Protein gp120; Humans; Molecular Sequence Data; Mutagenesis, Site-Directed; Protein Binding; Protein Structure, Tertiary; Sequence Analysis; Sequence Deletion; Sequence Homology, Amino Acid; Serine; Structure-Activity Relationship | 1997 |
Mutation of cysteine 111 in Dopa decarboxylase leads to active site perturbation.
Topics: 5-Hydroxytryptophan; Alanine; Animals; Base Sequence; Binding Sites; Circular Dichroism; Cysteine; Dopa Decarboxylase; Hydrogen-Ion Concentration; Kidney; Kinetics; Levodopa; Mutagenesis, Site-Directed; Pyridoxal Phosphate; Serine; Spectrometry, Fluorescence; Spectrophotometry; Structure-Activity Relationship; Swine | 1997 |
A conserved cysteine residue in yeast uroporphyrinogen decarboxylase is not essential for enzymatic activity.
Topics: Alanine; Cysteine; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Fungal; Mutagenesis, Site-Directed; Plasmids; Saccharomyces cerevisiae; Serine; Transformation, Genetic; Uroporphyrinogen Decarboxylase | 1997 |
Altered activity of palmitoylation-deficient and isoprenylated forms of the G protein-coupled receptor kinase GRK6.
Topics: Amino Acid Sequence; Amino Acid Substitution; Animals; Base Sequence; Cattle; COS Cells; Cysteine; DNA Primers; Eye Proteins; G-Protein-Coupled Receptor Kinase 1; G-Protein-Coupled Receptor Kinases; GTP-Binding Proteins; Isoproterenol; Kinetics; Liposomes; Molecular Sequence Data; Mutagenesis, Site-Directed; Palmitic Acid; Phosphatidylcholines; Phosphorylation; Polymerase Chain Reaction; Protein Kinases; Protein Prenylation; Protein Serine-Threonine Kinases; Receptor Protein-Tyrosine Kinases; Receptors, Adrenergic, beta-2; Recombinant Proteins; Retina; Rhodopsin; Sequence Deletion; Serine; Transfection | 1997 |
Assembly of a [2Fe-2S]2+ cluster in a molecular variant of Clostridium pasteurianum rubredoxin.
Topics: Binding Sites; Clostridium; Cysteine; Electron Spin Resonance Spectroscopy; Fourier Analysis; Iron; Ligands; Mass Spectrometry; Mutagenesis, Site-Directed; Recombinant Proteins; Rubredoxins; Serine; Spectrophotometry, Ultraviolet; Spectroscopy, Mossbauer; Spectrum Analysis, Raman; Structure-Activity Relationship; Sulfur | 1997 |
The effect of pH on the Ca2+ affinity of the Ca2+ regulatory sites of skeletal and cardiac troponin C in skinned muscle fibres.
Topics: Amino Acid Substitution; Animals; Binding Sites; Calcium; Cysteine; Fluorescent Dyes; Heart; Hydrogen-Ion Concentration; In Vitro Techniques; Muscle Contraction; Muscle Fibers, Skeletal; Muscle, Skeletal; Myocardial Contraction; Myocardium; Rabbits; Recombinant Proteins; Sarcomeres; Serine; Troponin C | 1997 |
Processing of mammalian and plant S-adenosylmethionine decarboxylase proenzymes.
Topics: Adenosylmethionine Decarboxylase; Amino Acid Sequence; Amino Acid Substitution; Cysteine; Enzyme Precursors; Humans; Molecular Sequence Data; Mutagenesis, Site-Directed; Protein Processing, Post-Translational; Putrescine; Pyruvic Acid; Serine; Solanum tuberosum; Structure-Activity Relationship; Threonine | 1997 |
The construction of a cysteine-less melibiose carrier from E. coli.
Topics: Amino Acid Substitution; Cell Membrane; Cysteine; DNA Primers; Escherichia coli; Ethylmaleimide; Hydrogen-Ion Concentration; Kinetics; Melibiose; Membrane Transport Proteins; Models, Structural; Mutagenesis, Site-Directed; Protein Structure, Secondary; Recombinant Proteins; Serine; Symporters; Valine | 1997 |
Formation of one or more intrachain disulphide bonds is required for the intracellular processing and transport of CD36.
Topics: Biological Transport; CD36 Antigens; Cell Compartmentation; Cell Membrane; Cysteine; Disulfides; Humans; Monocytes; Mutation; Oxidation-Reduction; Protein Precursors; Protein Processing, Post-Translational; Protein Structure, Secondary; Sequence Deletion; Serine; Subcellular Fractions | 1997 |
Site-directed mutagenesis of the Cys residues in ClpA, the ATPase component of protease Ti (ClpAP) in Escherichia coli.
Topics: Adenosine Triphosphatases; Alanine; Caseins; Cysteine; Electrophoresis, Polyacrylamide Gel; Endopeptidase Clp; Escherichia coli; Escherichia coli Proteins; Ethylmaleimide; Mutagenesis, Site-Directed; Serine; Serine Endopeptidases; Sulfhydryl Reagents | 1997 |
The cysteine residues of the M2 protein are not required for influenza A virus replication.
Topics: Amino Acid Substitution; Animals; Cysteine; Defective Viruses; DNA Primers; Ferrets; Horses; Influenza A virus; Mice; Mutagenesis, Site-Directed; Orthomyxoviridae Infections; Point Mutation; Polymerase Chain Reaction; Serine; Viral Matrix Proteins; Virus Replication | 1997 |
The role of cysteinyl residues in the activity of bacterial elongation factor Ts, a guanosine nucleotide dissociation protein.
Topics: Amino Acid Substitution; Cloning, Molecular; Cysteine; Escherichia coli; Glycine; Guanosine Diphosphate; Kinetics; Mutagenesis, Site-Directed; Peptide Elongation Factors; Protein Conformation; Recombinant Proteins; Sequence Tagged Sites; Serine | 1997 |
Identification of cysteine pairs within the amino-terminal 5% of apolipoprotein B essential for hepatic lipoprotein assembly and secretion.
Topics: Amino Acid Substitution; Animals; Apolipoproteins B; Carrier Proteins; Cysteine; Disulfides; Liver; Mutagenesis; Serine; Structure-Activity Relationship; Tumor Cells, Cultured | 1997 |
Iron-sulfur cluster cysteine-to-serine mutants of Anabaena -2Fe-2S- ferredoxin exhibit unexpected redox properties and are competent in electron transfer to ferredoxin:NADP+ reductase.
Topics: Anabaena; Crystallography, X-Ray; Cysteine; Electron Transport; Ferredoxin-NADP Reductase; Iron-Sulfur Proteins; Kinetics; Mutagenesis, Site-Directed; Oxidation-Reduction; Serine | 1997 |
The rat serotonin transporter: identification of cysteine residues important for substrate transport.
Topics: Alanine; Amino Acid Substitution; Animals; Carrier Proteins; Cell Line; Cell Membrane; Citalopram; Cysteine; Humans; Imipramine; Membrane Glycoproteins; Membrane Transport Proteins; Models, Molecular; Mutagenesis, Site-Directed; Nerve Tissue Proteins; Protein Conformation; Rats; Recombinant Proteins; Serine; Serotonin; Serotonin Plasma Membrane Transport Proteins; Transfection | 1997 |
Disulfide bond assignment in human interleukin-7 by matrix-assisted laser desorption/ionization mass spectroscopy and site-directed cysteine to serine mutational analysis.
Topics: Amino Acid Sequence; Amino Acid Substitution; Animals; Base Sequence; Cell Line; Cysteine; Humans; Interleukin-7; Mice; Molecular Sequence Data; Mutagenesis, Site-Directed; Peptide Mapping; Protein Folding; Protein Structure, Tertiary; Recombinant Proteins; Serine; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization | 1997 |
Esterification of 9-fluorenylmethoxycarbonyl-glycosylated serine and cysteine derivatives with an hydroxymethyl resin.
Topics: Alanine; Amino Acid Sequence; Amino Acids; Chromatography, High Pressure Liquid; Cysteine; Dinitrobenzenes; Esterification; Fluorenes; Glycosylation; Indicators and Reagents; Magnetic Resonance Spectroscopy; Peptides; Resins, Plant; Serine; Stereoisomerism; Triazines | 1997 |
Cysteine 195 has a critical functional role in catalysis by isocitrate lyase from Escherichia coli.
Topics: Alanine; Amino Acid Sequence; Amino Acid Substitution; Cysteine; Escherichia coli; Glycine; Isocitrate Lyase; Molecular Sequence Data; Mutagenesis, Site-Directed; Plasmids; Sequence Alignment; Sequence Analysis; Sequence Homology, Amino Acid; Serine; Threonine; Valine | 1997 |
The requirement for DsbA in pullulanase secretion is independent of disulphide bond formation in the enzyme.
Topics: Artificial Gene Fusion; Autoradiography; Cysteine; Disulfides; Electrophoresis, Polyacrylamide Gel; Endopeptidase K; Glycoside Hydrolases; Gram-Negative Bacteria; Klebsiella; Methionine; Mutagenesis, Site-Directed; Plasmids; Protein Disulfide-Isomerases; Serine; Sulfur Radioisotopes | 1998 |
Elimination of the Cys558-Cys566 bond in Lys78-plasminogen--effect on activation and fibrin interaction.
Topics: Animals; Cricetinae; Cysteine; Disulfides; Electrophoresis, Polyacrylamide Gel; Enzyme Activation; Fibrin; Fibrinolysin; Lysine; Plasminogen; Recombinant Proteins; Serine; Serine Endopeptidases; Streptokinase; Tissue Plasminogen Activator; Urokinase-Type Plasminogen Activator | 1998 |
Substitution of Arg-244 by Cys or Ser in SHV-1 and SHV-5 beta-lactamases confers resistance to mechanism-based inhibitors and reduces catalytic efficiency of the enzymes.
Topics: Amino Acid Substitution; Anti-Bacterial Agents; Arginine; beta-Lactamases; Clavulanic Acid; Cloning, Molecular; Cysteine; Escherichia coli; Microbial Sensitivity Tests; Penicillin Resistance; Serine | 1998 |
Human melanoma patients recognize an HLA-A1-restricted CTL epitope from tyrosinase containing two cysteine residues: implications for tumor vaccine development.
Topics: Alanine; Amino Acid Sequence; Amino Acid Substitution; Cancer Vaccines; Cysteine; Cytotoxicity, Immunologic; HLA-A1 Antigen; Humans; Immunodominant Epitopes; Melanoma; Monophenol Monooxygenase; Peptide Fragments; Serine; T-Lymphocytes, Cytotoxic; Tumor Cells, Cultured | 1998 |
Investigation of the potential active site of a cyanide dihydratase using site-directed mutagenesis.
Topics: Amino Acid Sequence; Amino Acid Substitution; Base Sequence; Binding Sites; Cysteine; Hydrolases; Kinetics; Molecular Sequence Data; Mutagenesis, Site-Directed; Oligodeoxyribonucleotides; Phenylalanine; Pseudomonas; Recombinant Proteins; Sequence Alignment; Sequence Homology, Amino Acid; Serine; Tyrosine | 1998 |
Non-canonical inteins.
Topics: Adenosine Triphosphatases; Alanine; Amino Acid Sequence; Base Sequence; Binding Sites; Consensus Sequence; Conserved Sequence; Cyanobacteria; Cysteine; Databases as Topic; Methanococcus; Molecular Sequence Data; Open Reading Frames; Peptide Library; Protein Splicing; Sequence Alignment; Sequence Homology, Amino Acid; Serine | 1998 |
Visualization of proteins by modification of lysines, cysteines, and phosphorylated serines facilitates sample preparation for microsequencing.
Topics: Amino Acid Sequence; Chromatography, High Pressure Liquid; Cysteine; Electrophoresis, Polyacrylamide Gel; Lysine; Mass Spectrometry; Molecular Sequence Data; Peptide Mapping; Phosphorylation; Proteins; Sequence Analysis; Serine; Trypsin | 1998 |
Factor X Nagoya 1 and Nagoya 2: a CRM- factor X deficiency and a dysfunctional CRM+ factor X deficiency characterized by substitution of Arg306 by Cys and of Gly366 by Ser, respectively.
Topics: Adult; Aged; Alleles; Cysteine; Factor X; Factor X Deficiency; Female; Glycine; Humans; Point Mutation; Serine; Structure-Activity Relationship | 1998 |
Kinetic and X-ray structural studies of three mutant E. coli alkaline phosphatases: insights into the catalytic mechanism without the nucleophile Ser102.
Topics: Alanine; Alkaline Phosphatase; Binding Sites; Catalysis; Crystallography, X-Ray; Cysteine; Escherichia coli; Glycine; Hydrogen-Ion Concentration; Kinetics; Models, Molecular; Mutagenesis, Site-Directed; Phosphates; Protein Conformation; Serine | 1998 |
Breaking up is easy with esters.
Topics: Cysteine; Enzyme Activation; Enzymes; Esters; Models, Chemical; Proteins; Serine; Sulfhydryl Compounds; Threonine | 1998 |
Structural and functional differences between glycosylated and non-glycosylated forms of human interferon-beta (IFN-beta).
Topics: Adjuvants, Immunologic; Antiviral Agents; Base Sequence; Cardiovirus Infections; Cell Division; Cell Line; Cysteine; Encephalomyocarditis virus; Glycosylation; Humans; Interferon beta-1a; Interferon beta-1b; Interferon-beta; Major Histocompatibility Complex; Molecular Sequence Data; Mutation; Recombinant Proteins; Serine | 1998 |
Mapping the promoter DNA sites proximal to conserved regions of sigma 70 in an Escherichia coli RNA polymerase-lacUV5 open promoter complex.
Topics: Amino Acid Sequence; Amino Acid Substitution; Conserved Sequence; Cysteine; DNA-Directed RNA Polymerases; DNA, Bacterial; Escherichia coli; Hydrolysis; Lac Operon; Models, Molecular; Mutagenesis, Site-Directed; Promoter Regions, Genetic; Serine; Sigma Factor; Templates, Genetic; Transcription, Genetic | 1998 |
Transmembrane topography of subunit a in the Escherichia coli F1F0 ATP synthase.
Topics: Adenosine Triphosphate; Amino Acid Sequence; Amino Acid Substitution; Base Sequence; Cell Membrane; Cysteine; Escherichia coli; Glutamine; Histidine; Molecular Sequence Data; Mutagenesis, Site-Directed; Protein Conformation; Protein Structure, Secondary; Proton-Translocating ATPases; Restriction Mapping; Serine; Spectrometry, Fluorescence; Sulfhydryl Reagents; Surface Properties | 1998 |
Disulfide analysis reveals a role for macrophage migration inhibitory factor (MIF) as thiol-protein oxidoreductase.
Topics: Animals; Cysteine; Disulfides; Humans; Leishmania; Macrophage Migration-Inhibitory Factors; Macrophages; Mutagenesis, Site-Directed; Protein Conformation; Protein Denaturation; Protein Disulfide Reductase (Glutathione); Protein Folding; Serine; Temperature | 1998 |
A cysteine-11 to serine mutant of G alpha12 impairs activation through the thrombin receptor.
Topics: Acylation; Amino Acid Sequence; Cysteine; Molecular Sequence Data; Mutagenesis, Site-Directed; Palmitic Acid; Protein Binding; Protein Processing, Post-Translational; Receptors, Thrombin; Serine; Signal Transduction | 1998 |
In vivo effects of anti-inducers of the cysteine regulon in Salmonella typhimurium.
Topics: Bacterial Proteins; Cysteine; Gene Expression Regulation, Bacterial; Genotype; Mutation; Operon; Regulon; Salmonella typhimurium; Serine; Sulfides; Thiosulfates; Transcription, Genetic | 1998 |
Functional significance of cysteine residues in the delta opioid receptor studied by site-directed mutagenesis.
Topics: Alanine; Amino Acid Sequence; Animals; Binding, Competitive; CHO Cells; Cricetinae; Cysteine; Membrane Proteins; Molecular Sequence Data; Mutagenesis, Site-Directed; Protein Conformation; Receptors, Opioid, delta; Serine | 1998 |
The dependence of Ag+ block of a potassium channel, murine kir2.1, on a cysteine residue in the selectivity filter.
Topics: Amino Acid Sequence; Amino Acid Substitution; Animals; Base Sequence; Binding Sites; CHO Cells; Conserved Sequence; Cricetinae; Cysteine; Dimerization; Kinetics; Macromolecular Substances; Mice; Models, Chemical; Molecular Sequence Data; Mutagenesis, Site-Directed; Oligodeoxyribonucleotides; Potassium Channel Blockers; Potassium Channels; Potassium Channels, Inwardly Rectifying; Recombinant Proteins; Serine; Silver; Transfection | 1998 |
Genetic polymorphisms and alternative splicing of the hOGG1 gene, that is involved in the repair of 8-hydroxyguanine in damaged DNA.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Alleles; Alternative Splicing; Cell Line; Codon; Cysteine; Deoxyguanosine; DNA; DNA Damage; DNA Repair; DNA-Formamidopyrimidine Glycosylase; Gene Frequency; Genes; Genetic Variation; Genotype; Humans; Leukocytes, Mononuclear; Loss of Heterozygosity; Lung Neoplasms; Mutation; N-Glycosyl Hydrolases; Polymorphism, Genetic; Serine; Transcription, Genetic; Tumor Cells, Cultured | 1998 |
Sulphur-containing amino acids are agonists for group 1 metabotropic receptors expressed in clonal RGT cell lines.
Topics: Amino Acids, Sulfur; Animals; Cell Line; Cricetinae; Cysteic Acid; Cysteine; Glutamic Acid; Homocysteine; Humans; Mesocricetus; Neurotransmitter Agents; Phosphatidylinositols; Receptor, Metabotropic Glutamate 5; Receptors, Metabotropic Glutamate; Serine | 1998 |
Interactions between serine acetyltransferase and O-acetylserine (thiol) lyase in higher plants--structural and kinetic properties of the free and bound enzymes.
Topics: Acetyltransferases; Arabidopsis; Chloroplasts; Cysteine; Cysteine Synthase; Enzyme Stability; Escherichia coli; Multienzyme Complexes; Protein Binding; Protein Conformation; Recombinant Proteins; Serine; Serine O-Acetyltransferase; Species Specificity; Titrimetry | 1998 |
Cysteine 42 is important for maintaining an integral active site for O-acetylserine sulfhydrylase resulting in the stabilization of the alpha-aminoacrylate intermediate.
Topics: Alanine; Binding Sites; Circular Dichroism; Cysteine; Cysteine Synthase; Deuterium; Enzyme Activation; Enzyme Stability; Hydrogen-Ion Concentration; Kinetics; Models, Molecular; Mutagenesis, Insertional; Serine; Spectrometry, Fluorescence; Spectrophotometry, Ultraviolet | 1998 |
Cysteine-scanning mutagenesis of flanking regions at the boundary between external loop I or IV and transmembrane segment II or VII in the GLUT1 glucose transporter.
Topics: 4-Chloromercuribenzenesulfonate; Amino Acid Sequence; Amino Acid Substitution; Animals; Biological Transport; Cysteine; Glucose; Glucose Transporter Type 1; Humans; Membrane Proteins; Models, Molecular; Molecular Sequence Data; Monosaccharide Transport Proteins; Mutagenesis, Site-Directed; Protein Structure, Secondary; Serine; Xenopus laevis | 1998 |
Rabbit beta-globin is extended beyond its UGA stop codon by multiple suppressions and translational reading gaps.
Topics: Amino Acid Sequence; Animals; Arginine; Codon, Terminator; Cysteine; Globins; Molecular Sequence Data; Peptide Chain Termination, Translational; Peptide Fragments; Protein Biosynthesis; Rabbits; Reading Frames; Serine; Suppression, Genetic; Tryptophan | 1998 |
Pfeiffer's syndrome resulting from an S351C mutation in the fibroblast growth factor receptor-2 gene.
Topics: Acrocephalosyndactylia; Amino Acid Substitution; Cysteine; Female; Humans; Infant, Newborn; Point Mutation; Polymerase Chain Reaction; Receptor Protein-Tyrosine Kinases; Receptor, Fibroblast Growth Factor, Type 2; Receptors, Fibroblast Growth Factor; Sequence Analysis, DNA; Serine | 1998 |
The nonactive site cysteine residues of yeast protein disulfide isomerase are not required for cell viability.
Topics: Amino Acid Sequence; Animals; Binding Sites; Caffeine; Cysteine; Dithiothreitol; Mammals; Point Mutation; Protein Disulfide-Isomerases; Saccharomyces cerevisiae; Serine | 1998 |
Identification of the essential cysteinyl residue located in the active site of human phenylethanolamine N-methyltransferase.
Topics: Amino Acid Sequence; Animals; Binding Sites; Cysteine; Escherichia coli; Gene Expression; Humans; Kinetics; Molecular Sequence Data; Mutagenesis, Site-Directed; Norepinephrine; Phenylethanolamine N-Methyltransferase; Polymerase Chain Reaction; S-Adenosylmethionine; Sequence Homology; Serine; Substrate Specificity | 1998 |
Phenotype of the fibroblast growth factor receptor 2 Ser351Cys mutation: Pfeiffer syndrome type III.
Topics: Abnormalities, Multiple; Acrocephalosyndactylia; Amino Acid Substitution; Cysteine; Elbow; Eye Abnormalities; Foot Deformities, Congenital; Hand Deformities, Congenital; Humans; Infant, Newborn; Male; Phenotype; Point Mutation; Polymorphism, Single-Stranded Conformational; Radiography; Receptor Protein-Tyrosine Kinases; Receptor, Fibroblast Growth Factor, Type 2; Receptors, Fibroblast Growth Factor; Serine; Translocation, Genetic; Wheelchairs | 1998 |
Effects of the cys mutations on structure and function of the ATP-dependent HslVU protease in Escherichia coli. The Cys287 to Val mutation in HslU uncouples the ATP-dependent proteolysis by HslvU from ATP hydrolysis.
Topics: Adenosine Triphosphatases; Adenosine Triphosphate; Alanine; ATP-Dependent Proteases; Cysteine; Endopeptidases; Escherichia coli; Ethylmaleimide; Heat-Shock Proteins; Hydrolysis; Mutagenesis, Site-Directed; Protein Conformation; Serine; Serine Endopeptidases; Substrate Specificity; Valine | 1998 |
A recombinant monocysteine mutant (Ser to Cys-155) of fast skeletal troponin T: identification by cross-linking of a domain involved in a physiologically relevant interaction with troponins C and I.
Topics: Animals; Cross-Linking Reagents; Cysteine; Escherichia coli; Genetic Vectors; Humans; Muscle Fibers, Fast-Twitch; Photochemistry; Protein Structure, Tertiary; Rabbits; Recombinant Proteins; Serine; Troponin; Troponin C; Troponin I; Troponin T | 1998 |
Gas chromatography/mass spectrometry analyses of [2,3,3-d3] serine, [2,3,3-d3] cysteine and [3-13 C] cysteine in plasma and skin protein: measurement of transsulphuration in young sheep.
Topics: Amino Acids, Sulfur; Animals; Blood Proteins; Cysteine; Diet; Dithiothreitol; Female; Gas Chromatography-Mass Spectrometry; Hydrolysis; Indicators and Reagents; Proteins; Serine; Sheep; Skin | 1998 |
Kinetic studies of FR-1, a growth factor-inducible aldo-keto reductase.
Topics: Aldehyde Reductase; Aldehydes; Amino Acid Substitution; Animals; Binding Sites; Cysteine; Enzyme Activation; Epidermal Growth Factor; Growth Substances; Kinetics; Mass Spectrometry; Mice; Mutagenesis, Site-Directed; Protein Biosynthesis; Proteins; Serine; Substrate Specificity | 1998 |
Posttranslational formation of formylglycine in prokaryotic sulfatases by modification of either cysteine or serine.
Topics: Alanine; Arylsulfatases; Bacterial Proteins; Binding Sites; Borohydrides; Cysteine; Glycine; Klebsiella pneumoniae; Mutagenesis, Site-Directed; Peptide Fragments; Prokaryotic Cells; Protein Processing, Post-Translational; Pseudomonas aeruginosa; Recombinant Proteins; Sequence Analysis; Serine; Sulfates; Trypsin | 1998 |
Direct voltammetric observation of redox driven changes in axial coordination and intramolecular rearrangement of the phenylalanine-82-histidine variant of yeast iso-1-cytochrome c.
Topics: Amino Acid Substitution; Animals; Cysteine; Cytochrome c Group; Cytochromes c; Electrochemistry; Histidine; Horses; Imidazoles; Mutagenesis, Site-Directed; Oxidation-Reduction; Phenylalanine; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Serine | 1998 |
Functional role of cysteine residues in the Na+/H+ exchanger effects of mutation of cysteine residues on targeting and activity of the Na+/H+ exchanger.
Topics: Amino Acid Substitution; Animals; Arginine; Cell Line; Cricetinae; Cysteine; Humans; Isomerism; Mice; Mutagenesis, Site-Directed; Rabbits; Rats; Serine; Sodium-Hydrogen Exchangers; Swine | 1998 |
Catalytic competence of O-acetylserine sulfhydrylase in the crystal probed by polarized absorption microspectrophotometry.
Topics: Alanine; Catalysis; Crystallization; Cysteine; Cysteine Synthase; Hydrogen-Ion Concentration; Microspectrophotometry; Models, Chemical; Salmonella typhimurium; Serine; Sodium Azide; Structure-Activity Relationship | 1998 |
Conformational changes in the cytoplasmic domain of the Escherichia coli aspartate receptor upon adaptive methylation.
Topics: Amides; Chemotaxis; Cross-Linking Reagents; Cysteine; Cytoplasm; Disulfides; Escherichia coli; Leucine; Methylation; Mutagenesis, Site-Directed; Peptide Fragments; Protein Conformation; Protein Structure, Tertiary; Receptors, Amino Acid; Serine; Valine | 1998 |
Investigation of a catalytic zinc binding site in Escherichia coli L-threonine dehydrogenase by site-directed mutagenesis of cysteine-38.
Topics: Alcohol Oxidoreductases; Aspartic Acid; Binding Sites; Catalysis; Cations, Divalent; Circular Dichroism; Cysteine; Enzyme Activation; Escherichia coli; Hydrogen-Ion Concentration; Molecular Weight; Mutagenesis, Site-Directed; Protein Conformation; Serine; Spectrophotometry, Atomic; Zinc | 1998 |
Conformational and dynamic changes of Yersinia protein tyrosine phosphatase induced by ligand binding and active site mutation and revealed by H/D exchange and electrospray ionization Fourier transform ion cyclotron resonance mass spectrometry.
Topics: Amino Acid Sequence; Binding Sites; Cyclotrons; Cysteine; Deuterium; Endopeptidases; Hydrogen; Hydrolysis; Ligands; Mass Spectrometry; Molecular Sequence Data; Mutagenesis, Site-Directed; Peptide Fragments; Protein Binding; Protein Conformation; Protein Tyrosine Phosphatases; Serine; Spectroscopy, Fourier Transform Infrared; Thermodynamics; Threonine; Yersinia | 1998 |
Mutational analysis of the cysteines in the extracellular domain of the human Ca2+ receptor: effects on cell surface expression, dimerization and signal transduction.
Topics: Amino Acid Substitution; Calcium; Cell Line; Cysteine; Dimerization; Humans; Kinetics; Mutagenesis, Site-Directed; Phosphatidylinositols; Receptors, Calcium-Sensing; Receptors, Cell Surface; Recombinant Proteins; Serine; Signal Transduction; Transfection | 1998 |
m-Calpain subunits remain associated in the presence of calcium.
Topics: Alanine; Animals; Calcium; Calpain; Caseins; Catalytic Domain; Cattle; Cysteine; Dimerization; Glutamic Acid; Kinetics; Macromolecular Substances; Mutagenesis, Site-Directed; Protein Binding; Recombinant Proteins; Serine | 1998 |
Determinants of strand register in antiparallel beta-sheets of proteins.
Topics: Binding Sites; Computer Simulation; Cysteine; Disulfides; Hydrogen Bonding; Isoleucine; Models, Molecular; Peptides; Proline; Protein Conformation; Protein Structure, Secondary; Serine; Threonine; Valine | 1998 |
Reactivity of the human thioltransferase (glutaredoxin) C7S, C25S, C78S, C82S mutant and NMR solution structure of its glutathionyl mixed disulfide intermediate reflect catalytic specificity.
Topics: Amino Acid Sequence; Animals; Binding Sites; Catalysis; Crystallography, X-Ray; Cysteine; Escherichia coli; Glutaredoxins; Glutathione Disulfide; Humans; Liver; Molecular Sequence Data; Mutagenesis, Site-Directed; Nuclear Magnetic Resonance, Biomolecular; Oxidoreductases; Protein Disulfide Reductase (Glutathione); Protein Structure, Secondary; Proteins; Serine; Solutions; Substrate Specificity; Swine | 1998 |
Effect of cysteine modifications on the activity of the 'small' Clostridium perfringens sialidase.
Topics: Amino Acid Sequence; Clostridium perfringens; Cysteine; Ethylmaleimide; Gram-Positive Bacteria; Kinetics; Mercuric Chloride; Molecular Sequence Data; Mutagenesis, Site-Directed; Neuraminidase; p-Chloromercuribenzoic Acid; Recombinant Proteins; Sequence Homology, Amino Acid; Serine; Structure-Activity Relationship; Substrate Specificity | 1998 |
The catalytic mechanism of the glutathione-dependent dehydroascorbate reductase activity of thioltransferase (glutaredoxin).
Topics: Animals; Ascorbic Acid; Catalysis; Cysteine; Dehydroascorbic Acid; Enzyme Activation; Enzyme Inhibitors; Glutaredoxins; Glutathione; Iodoacetamide; Isoelectric Focusing; Kinetics; Liver; Models, Chemical; Oxidation-Reduction; Oxidoreductases; Protein Disulfide Reductase (Glutathione); Recombinant Proteins; Serine; Swine | 1999 |
Characterization of the Escherichia coli CcmH protein reveals new insights into the redox pathway required for cytochrome c maturation.
Topics: Bacterial Proteins; Cell Fractionation; Cysteine; Cytochrome c Group; Escherichia coli; Gene Deletion; Genes, Bacterial; Oxidation-Reduction; Phenotype; Plasmids; Point Mutation; Serine; Toluene | 1999 |
Mutational analysis of cysteine-rich domains of the epithelium sodium channel (ENaC). Identification of cysteines essential for channel expression at the cell surface.
Topics: Animals; Cysteine; DNA Mutational Analysis; Epithelial Sodium Channels; Humans; Mutagenesis, Site-Directed; Protein Conformation; Rats; Serine; Sodium Channels; Surface Properties; Xenopus | 1999 |
Importance of conserved cysteines in the extracellular loops of human PACAP/VIP1 receptor for ligand binding and stimulation of cAMP production.
Topics: Alanine; Amino Acid Substitution; Binding, Competitive; Cell Line; Cell Membrane; Conserved Sequence; Cyclic AMP; Cysteine; Humans; Models, Molecular; Mutagenesis, Site-Directed; Protein Structure, Secondary; Receptors, Pituitary Adenylate Cyclase-Activating Polypeptide; Receptors, Pituitary Hormone; Receptors, Vasoactive Intestinal Peptide; Receptors, Vasoactive Intestinal Polypeptide, Type I; Recombinant Proteins; Serine; Transfection; Vasoactive Intestinal Peptide | 1998 |
An antiviral mechanism of nitric oxide: inhibition of a viral protease.
Topics: 3C Viral Proteases; Amino Acid Substitution; Antiviral Agents; Binding Sites; Cysteine; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Enterovirus B, Human; HeLa Cells; Humans; Hydrolysis; Mutagenesis, Site-Directed; Nitric Oxide; Nitroso Compounds; Serine; Viral Proteins | 1999 |
Kinetic mechanism of Tritrichomonas foetus inosine 5'-monophosphate dehydrogenase.
Topics: Amino Acid Substitution; Animals; Binding Sites; Cysteine; Deuterium; Humans; IMP Dehydrogenase; Kinetics; Ligands; Models, Chemical; Mutagenesis, Site-Directed; Mycophenolic Acid; NAD; Protein Binding; Serine; Spectrometry, Fluorescence; Thermodynamics; Tritrichomonas foetus | 1999 |
Coenzyme A-disulfide reductase from Staphylococcus aureus: evidence for asymmetric behavior on interaction with pyridine nucleotides.
Topics: Catalysis; Coenzyme A; Cysteine; Dithionite; Ferricyanides; Isoenzymes; Mass Spectrometry; NADH, NADPH Oxidoreductases; NADP; Oxidation-Reduction; Recombinant Proteins; Serine; Spectrometry, Fluorescence; Spectrophotometry; Staphylococcus aureus | 1999 |
Conformational unfolding studies of three-disulfide mutants of bovine pancreatic ribonuclease A and the coupling of proline isomerization to disulfide redox reactions.
Topics: Alanine; Amino Acid Substitution; Animals; Cattle; Cysteine; Disulfides; Mutagenesis, Site-Directed; Oxidation-Reduction; Proline; Protein Conformation; Protein Folding; Protein Isoforms; Ribonuclease, Pancreatic; Serine; Spectrometry, Fluorescence; Spectrophotometry | 1999 |
Equilibrium analyses of the active-site asymmetry in enterococcal NADH oxidase: role of the cysteine-sulfenic acid redox center.
Topics: Bacterial Proteins; Binding Sites; Coenzymes; Cysteine; Dithionite; Electron Transport; Enzyme Stability; Hydrogen-Ion Concentration; Multienzyme Complexes; Mutagenesis, Site-Directed; NAD; NADH, NADPH Oxidoreductases; NADP; Oxidation-Reduction; Recombinant Proteins; Serine; Spectrometry, Fluorescence; Sulfenic Acids | 1999 |
HlyC, the internal protein acyltransferase that activates hemolysin toxin: role of conserved histidine, serine, and cysteine residues in enzymatic activity as probed by chemical modification and site-directed mutagenesis.
Topics: Acetyltransferases; Acyltransferases; Amino Acid Sequence; Bacterial Proteins; Bacterial Toxins; Catalysis; Conserved Sequence; Cysteine; Enzyme Activation; Escherichia coli; Escherichia coli Proteins; Hemolysin Proteins; Histidine; Molecular Sequence Data; Mutagenesis, Site-Directed; Peptides; Repetitive Sequences, Amino Acid; Serine | 1999 |
Redox-dependent regulation of nuclear import of the glucocorticoid receptor.
Topics: Amino Acid Sequence; Amino Acid Substitution; Animals; Biological Transport; Cell Nucleus; CHO Cells; COS Cells; Cricetinae; Cysteine; Green Fluorescent Proteins; Humans; Hydrogen Peroxide; Ligands; Luminescent Proteins; Molecular Sequence Data; Oxidation-Reduction; Oxidative Stress; Receptors, Glucocorticoid; Recombinant Fusion Proteins; Serine; Signal Transduction; Zinc Fingers | 1999 |
Catalytic acid/base residues of glutamate racemase.
Topics: Amino Acid Isomerases; Amino Acids; Catalysis; Cysteine; Deuterium; Glutamates; Hydrogen-Ion Concentration; Kinetics; Lactobacillus; Mutagenesis, Site-Directed; Serine; Stereoisomerism | 1999 |
Derivatization of the interface cysteine of triosephosphate isomerase from Trypanosoma brucei and Trypanosoma cruzi as probe of the interrelationship between the catalytic sites and the dimer interface.
Topics: Animals; Catalysis; Cysteine; Dimerization; Dithionitrobenzoic Acid; Enzyme Activation; Enzyme Inhibitors; Glyceraldehyde 3-Phosphate; Glycolates; Methyl Methanesulfonate; Mutagenesis, Site-Directed; Serine; Substrate Specificity; Sulfhydryl Reagents; Triose-Phosphate Isomerase; Trypanosoma brucei brucei; Trypanosoma cruzi | 1999 |
Dimerization of the calcium-sensing receptor occurs within the extracellular domain and is eliminated by Cys --> Ser mutations at Cys101 and Cys236.
Topics: Base Sequence; Cell Line; Cysteine; Dimerization; Disulfides; DNA Primers; Green Fluorescent Proteins; Humans; Luminescent Proteins; Point Mutation; Receptors, Calcium-Sensing; Receptors, Cell Surface; Serine | 1999 |
Structural consequences of the active site substitution Cys181 ==> Ser in metallo-beta-lactamase from Bacteroides fragilis.
Topics: Amino Acid Substitution; Bacteroides fragilis; beta-Lactamases; Binding Sites; Cysteine; Models, Molecular; Protein Conformation; Serine; Zinc | 1999 |
Characterization of catalytic centre mutants of macrophage migration inhibitory factor (MIF) and comparison to Cys81Ser MIF.
Topics: Base Sequence; Catalytic Domain; Circular Dichroism; Cysteine; Disulfides; DNA Primers; Humans; Macrophage Migration-Inhibitory Factors; Mutagenesis, Site-Directed; Protein Conformation; Serine; Spectrophotometry, Ultraviolet; Structure-Activity Relationship | 1999 |
A Cys-less variant of the bacterial ATP binding cassette protein MalK is functional in maltose transport and regulation.
Topics: Adenosine Triphosphatases; Adenosine Triphosphate; ATP-Binding Cassette Transporters; Bacterial Proteins; Biological Transport; Cysteine; Enzyme Inhibitors; Ethylmaleimide; Maltose; Mutagenesis, Site-Directed; Salmonella typhimurium; Serine | 1999 |
Cutting edge: the tyrosine phosphatase SHP-1 regulates thymocyte positive selection.
Topics: Animals; CD4-Positive T-Lymphocytes; Cysteine; Intracellular Signaling Peptides and Proteins; Mice; Mice, Transgenic; Mutation; Protein Tyrosine Phosphatase, Non-Receptor Type 11; Protein Tyrosine Phosphatase, Non-Receptor Type 6; Protein Tyrosine Phosphatases; Receptors, Antigen, T-Cell; Serine; SH2 Domain-Containing Protein Tyrosine Phosphatases; Signal Transduction; Spleen; src Homology Domains; Thymus Gland | 1999 |
Binding-dependent disorder-order transition in PKI alpha: a fluorescence anisotropy study.
Topics: Amino Acid Sequence; Animals; Binding, Competitive; Carrier Proteins; Catalysis; Cyclic AMP-Dependent Protein Kinases; Cysteine; Enzyme Inhibitors; Fluorescence Polarization; Intracellular Signaling Peptides and Proteins; Mice; Molecular Sequence Data; Mutagenesis, Site-Directed; Protein Binding; Protein Isoforms; Recombinant Proteins; Serine; Spectrometry, Fluorescence; Valine | 1999 |
Site-directed mutagenesis of the cysteine ligands to the [4Fe-4S] cluster of Escherichia coli MutY.
Topics: Alanine; Cell Fractionation; Cysteine; DNA Glycosylases; DNA Repair; DNA, Bacterial; Enzyme Activation; Enzyme Stability; Escherichia coli; Histidine; Iron-Sulfur Proteins; Ligands; Models, Molecular; Mutagenesis, Site-Directed; N-Glycosyl Hydrolases; Protein Binding; Recombinant Proteins; Serine | 1999 |
The amino acidic substitution of cysteine 167 by serine (C167S) in BstVI restriction endonuclease of Bacillus stearothermophilus V affects its conformation and thermostability.
Topics: Amino Acid Substitution; Base Sequence; Cations, Divalent; Cysteine; Deoxyribonucleases, Type II Site-Specific; DNA Primers; Electrophoresis, Agar Gel; Endopeptidases; Enzyme Stability; Geobacillus stearothermophilus; Hot Temperature; Hydrogen-Ion Concentration; Hydrolysis; Mutagenesis, Site-Directed; Osmolar Concentration; Protein Conformation; Protein Denaturation; Serine; Sulfhydryl Compounds | 1999 |
Modulation of the affinity and selectivity of RGS protein interaction with G alpha subunits by a conserved asparagine/serine residue.
Topics: Animals; Asparagine; Binding, Competitive; Conserved Sequence; Cysteine; GTP-Binding Protein alpha Subunits, Gi-Go; GTP-Binding Protein alpha Subunits, Gq-G11; GTP-Binding Proteins; GTPase-Activating Proteins; Guanosine Triphosphate; Humans; Hydrolysis; Lysine; Mutagenesis, Site-Directed; Proline; Protein Binding; Proteins; Receptors, Cell Surface; RGS Proteins; Serine | 1999 |
Cysteine residues in a synthetic peptide corresponding to human follicle-stimulating hormone beta-subunit receptor-binding domain 81-95 [hFSH-beta-(81-95)] modulate the in vivo effects of hFSH-beta-(81-95) on the mouse estrous cycle.
Topics: Amino Acid Sequence; Amino Acid Substitution; Animals; Binding Sites; Cysteine; Estrus; Female; Follicle Stimulating Hormone; Follicle Stimulating Hormone, beta Subunit; Follicle Stimulating Hormone, Human; Humans; Mice; Molecular Sequence Data; Peptide Fragments; Serine | 1999 |
Allelic variation of the 5-HT2C receptor (HTR2C) in bulimia nervosa and binge eating disorder.
Topics: Adolescent; Adult; Alleles; Bulimia; Case-Control Studies; Codon; Cysteine; Ethnicity; Feeding and Eating Disorders; Female; Genetic Variation; Humans; Receptor, Serotonin, 5-HT2C; Receptors, Serotonin; Serine | 1999 |
Site-directed mutagenesis and molecular modeling identify a crucial amino acid in specifying the heparin affinity of FGF-1.
Topics: Amino Acid Sequence; Amino Acids; Animals; Binding Sites; Cattle; Cysteic Acid; Cysteine; Fibroblast Growth Factor 1; Fibroblast Growth Factor 2; Heparin; Humans; Iodine Radioisotopes; Models, Molecular; Molecular Sequence Data; Mutagenesis, Site-Directed; Oxidation-Reduction; Phenylalanine; Recombinant Fusion Proteins; Recombinant Proteins; Serine; Tyrosine | 1999 |
Structural characterization of the membrane-associated regulatory subunit of type I cAMP-dependent protein kinase by mass spectrometry: identification of Ser81 as the in vivo phosphorylation site of RIalpha.
Topics: Amino Acid Sequence; Animals; Cattle; Cyclic AMP-Dependent Protein Kinase RIalpha Subunit; Cyclic AMP-Dependent Protein Kinases; Cysteine; Mass Spectrometry; Membrane Proteins; Molecular Sequence Data; Phosphorylation; Serine | 1999 |
Effect of serinate ligation at each of the iron sites of the [Fe4S4] cluster of Pyrococcus furiosus ferredoxin on the redox, spectroscopic, and biological properties.
Topics: Amino Acid Sequence; Aspartic Acid; Circular Dichroism; Cysteine; Electrochemistry; Electron Spin Resonance Spectroscopy; Ferredoxin-NADP Reductase; Ferredoxins; Iron; Ligands; Molecular Sequence Data; Mutagenesis, Site-Directed; Oxidation-Reduction; Pyrococcus furiosus; Serine; Spectrophotometry, Ultraviolet; Spectrum Analysis, Raman; Sulfur | 1999 |
C172S substitution in the chloroplast-encoded large subunit affects stability and stress-induced turnover of ribulose-1,5-bisphosphate carboxylase/oxygenase.
Topics: Amino Acid Substitution; Animals; Chlamydomonas reinhardtii; Chloroplasts; Circular Dichroism; Cysteine; Enzyme Stability; Mutagenesis, Site-Directed; Oxidation-Reduction; Phenotype; Protein Conformation; Ribulose-Bisphosphate Carboxylase; Serine; Spectrophotometry, Ultraviolet | 1999 |
In vivo oxidation-reduction kinetics of OxyR, the transcriptional activator for an oxidative stress-inducible regulon in Escherichia coli.
Topics: Cysteine; Disulfides; DNA-Binding Proteins; Electrophoresis, Polyacrylamide Gel; Escherichia coli; Escherichia coli Proteins; Hydrogen Peroxide; Kinetics; Mutagenesis, Site-Directed; Oxidation-Reduction; Oxidative Stress; Repressor Proteins; Serine; Time Factors; Transcription Factors; Transcriptional Activation; Transformation, Bacterial | 1999 |
Excision of oxidatively damaged DNA bases by the human alpha-hOgg1 protein and the polymorphic alpha-hOgg1(Ser326Cys) protein which is frequently found in human populations.
Topics: Amino Acid Substitution; Cysteine; DNA Damage; DNA Repair; DNA-Formamidopyrimidine Glycosylase; Electrophoresis, Polyacrylamide Gel; Escherichia coli; Escherichia coli Proteins; Gas Chromatography-Mass Spectrometry; Glutathione Transferase; Humans; N-Glycosyl Hydrolases; Oxidative Stress; Phenotype; Serine; Substrate Specificity | 1999 |
Cysteine-rich regions of pig gastric mucin contain von willebrand factor and cystine knot domains at the carboxyl terminal(1).
Topics: Amino Acid Sequence; Animals; Base Sequence; Cysteine; Cystine; DNA, Complementary; Epithelium; Gastric Mucins; Gastric Mucosa; Hydrogen-Ion Concentration; Molecular Sequence Data; Sequence Alignment; Serine; Swine; Tandem Repeat Sequences; Threonine; von Willebrand Factor | 1999 |
Significance of metal ions in galactose-1-phosphate uridylyltransferase: an essential structural zinc and a nonessential structural iron.
Topics: Asparagine; Binding Sites; Chromatography, Affinity; Circular Dichroism; Cysteine; Dialysis; Edetic Acid; Enzyme Activation; Escherichia coli; Histidine; Iron; Kinetics; Ligands; Mutagenesis, Site-Directed; Phenanthrolines; Recombinant Proteins; Serine; Structure-Activity Relationship; Triazines; UDPglucose-Hexose-1-Phosphate Uridylyltransferase; Uridine Diphosphate Glucose; Zinc | 1999 |
Identification of two serine residues involved in catalysis by fatty acid amide hydrolase.
Topics: Alanine; Amidohydrolases; Amino Acid Sequence; Animals; Binding Sites; Catalysis; COS Cells; Cysteine; Isoflurophate; Molecular Sequence Data; Mutagenesis, Site-Directed; Mutation; Phospholipases A; Protease Inhibitors; Serine; Sulfhydryl Compounds | 1999 |
Properties of the mutant Ser-460-Cys implicate this site in a functionally important region of the type IIa Na(+)/P(i) cotransporter protein.
Topics: Alkylation; Amino Acid Sequence; Amino Acid Substitution; Animals; Carrier Proteins; Cysteine; Electrophysiology; Ethyl Methanesulfonate; Indicators and Reagents; Ion Channel Gating; Kinetics; Membrane Potentials; Molecular Sequence Data; Mutagenesis; Oocytes; Phosphates; Protein Structure, Tertiary; Rats; RNA, Complementary; Serine; Sodium; Sodium-Phosphate Cotransporter Proteins; Sodium-Phosphate Cotransporter Proteins, Type IIa; Structure-Activity Relationship; Symporters; Xenopus laevis | 1999 |
Effect of glutathione L-cystein and L-djenkolic acid in the synthesis and mutagenicity of azide metabolite in Bacillus subtilis ATCC 6633 strain.
Topics: Bacillus subtilis; Cysteine; Dithiothreitol; Glutathione; Mutagens; Serine; Sodium Azide | 1999 |
Posttranslational heterocyclization of cysteine and serine residues in the antibiotic microcin B17: distributivity and directionality.
Topics: Amino Acid Sequence; Anti-Bacterial Agents; Bacterial Proteins; Bacteriocins; Cysteine; Histidine; Hydrolysis; Kinetics; Mass Spectrometry; Molecular Sequence Data; Multienzyme Complexes; Protein Precursors; Protein Processing, Post-Translational; Protein Sorting Signals; Recombinant Fusion Proteins; Serine; Substrate Specificity | 1999 |
Expressed protein ligation to probe regiospecificity of heterocyclization in the peptide antibiotic microcin B17.
Topics: Amino Acid Sequence; Anti-Bacterial Agents; Bacterial Proteins; Bacteriocins; Cysteine; Escherichia coli; Isomerism; Models, Molecular; Molecular Sequence Data; Multienzyme Complexes; Mutagenesis; Peptides; Protein Conformation; Serine | 1999 |
The small subunit of carbamoyl phosphate synthetase: snapshots along the reaction pathway.
Topics: Apoenzymes; Asparagine; Carbamoyl-Phosphate Synthase (Glutamine-Hydrolyzing); Crystallography, X-Ray; Cysteine; Escherichia coli; Glutamine; Histidine; Hydrolysis; Kinetics; Mutagenesis, Site-Directed; Peptide Fragments; Serine; Stereoisomerism | 1999 |
A conserved serine-rich stretch in the glutamate transporter family forms a substrate-sensitive reentrant loop.
Topics: Amino Acid Motifs; Amino Acid Sequence; Amino Acid Transport System X-AG; ATP-Binding Cassette Transporters; Conserved Sequence; Cysteine; Ethylmaleimide; Glutamic Acid; Molecular Sequence Data; Serine | 1999 |
O-Acetylserine sulfhydrylase from Methanosarcina thermophila.
Topics: Amino Acid Sequence; Archaeal Proteins; Carbon-Oxygen Lyases; Cysteine; Cysteine Synthase; Dimerization; Electrophoresis, Polyacrylamide Gel; Isoelectric Focusing; Kinetics; Methanosarcina; Molecular Sequence Data; Multienzyme Complexes; Saccharomyces cerevisiae Proteins; Sequence Homology, Amino Acid; Serine; Spectrophotometry, Ultraviolet; Sulfides; Sulfur | 2000 |
A cysteine-free firefly luciferase retains luminescence activity.
Topics: Amino Acid Sequence; Amino Acid Substitution; Animals; Coleoptera; Cysteine; Luciferases; Luminescent Measurements; Models, Molecular; Molecular Sequence Data; Mutagenesis, Site-Directed; Protein Conformation; Protein Structure, Secondary; Recombinant Proteins; Serine | 2000 |
Enhancement of insulin-like growth factor I activity by novel antisera: potential structure/function interactions.
Topics: Amino Acid Sequence; Animals; Cattle; Cell Line; Cysteine; Dwarfism; Epitopes; Fibroblasts; Humans; Immune Sera; Insulin; Insulin-Like Growth Factor I; Insulin-Like Growth Factor II; Mice; Mice, Mutant Strains; Models, Molecular; Molecular Sequence Data; Nuclear Magnetic Resonance, Biomolecular; Protein Structure, Secondary; Recombinant Proteins; Sequence Alignment; Sequence Homology, Amino Acid; Serine; Vertebrates; Weight Gain | 2000 |
Processing and reactivity of T cell epitopes containing two cysteine residues from hen egg-white lysozyme (HEL74-90).
Topics: Amino Acid Sequence; Amino Acid Substitution; Animals; Antigen Presentation; Antigen-Presenting Cells; Chickens; Cysteine; Epitopes, T-Lymphocyte; Female; Histocompatibility Antigens Class II; Hybridomas; Immune Tolerance; Lymphocyte Activation; Methylation; Mice; Mice, Inbred C3H; Mice, Inbred C57BL; Molecular Sequence Data; Muramidase; Oxidation-Reduction; Peptide Fragments; Protein Folding; Serine; T-Lymphocyte Subsets | 2000 |
A redox mechanism controls differential DNA binding activities of hypoxia-inducible factor (HIF) 1alpha and the HIF-like factor.
Topics: Amino Acid Sequence; Carbon-Oxygen Lyases; Cysteine; DNA; DNA-(Apurinic or Apyrimidinic Site) Lyase; DNA-Binding Proteins; Gene Expression Regulation; HeLa Cells; Helix-Loop-Helix Motifs; Humans; Hypoxia-Inducible Factor 1; Hypoxia-Inducible Factor 1, alpha Subunit; Molecular Sequence Data; Mutagenesis, Site-Directed; Nuclear Proteins; Oligonucleotides, Antisense; Oxidation-Reduction; Recombinant Proteins; Sequence Homology, Amino Acid; Serine; Transcription Factors | 2000 |
Dissecting the interaction of SHP-2 with PZR, an immunoglobulin family protein containing immunoreceptor tyrosine-based inhibitory motifs.
Topics: Blotting, Western; Carrier Proteins; Catalysis; Cell Line; Cysteine; DNA, Complementary; Humans; Intracellular Signaling Peptides and Proteins; Jurkat Cells; Models, Chemical; Mutagenesis, Site-Directed; Phosphoproteins; Phosphorylation; Precipitin Tests; Protein Binding; Protein Tyrosine Phosphatase, Non-Receptor Type 11; Protein Tyrosine Phosphatase, Non-Receptor Type 6; Protein Tyrosine Phosphatases; Serine; SH2 Domain-Containing Protein Tyrosine Phosphatases; src Homology Domains; Tyrosine | 2000 |
Mutation of R116C results in highly oligomerized alpha A-crystallin with modified structure and defective chaperone-like function.
Topics: Animals; Arginine; Biopolymers; Chromatography, Gel; Cloning, Molecular; Crystallins; Cysteine; Hot Temperature; Molecular Chaperones; Molecular Weight; Mutagenesis, Site-Directed; Protein Conformation; Protein Structure, Secondary; Protein Structure, Tertiary; Rats; Recombinant Proteins; Serine; Spectrometry, Fluorescence | 2000 |
Role of the loop containing residue 115 in the induced-fit mechanism of the bacterial cell wall biosynthetic enzyme MurA.
Topics: Alkyl and Aryl Transferases; Amino Acid Substitution; Catalysis; Cell Wall; Conserved Sequence; Crystallography, X-Ray; Cysteine; Enterobacter cloacae; Enzyme Activation; Enzyme Inhibitors; Fosfomycin; Ligands; Mutagenesis, Site-Directed; Peptide Fragments; Serine; Spectrometry, Fluorescence; Thermodynamics | 2000 |
Enzyme I of the phosphoenolpyruvate:sugar phosphotransferase system. In vitro intragenic complementation: the roles of Arg126 in phosphoryl transfer and the C-terminal domain in dimerization.
Topics: Amino Acid Sequence; Arginine; Bacterial Proteins; Cysteine; Dimerization; Enzyme Activation; Genes, Bacterial; Genetic Complementation Test; Glycine; Kinetics; Molecular Sequence Data; Peptide Fragments; Phosphoenolpyruvate Sugar Phosphotransferase System; Phosphorylation; Phosphotransferases (Nitrogenous Group Acceptor); Point Mutation; Protein Structure, Tertiary; Salmonella typhimurium; Serine; Temperature | 2000 |
Ligand recognition of serine-cysteine amino acid exchanges in transmembrane domain 5 of alpha2-adrenergic receptors by UK 14,304.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Binding Sites; Binding, Competitive; Brimonidine Tartrate; Chlorpromazine; CHO Cells; Cricetinae; Cysteine; Dopamine Antagonists; Humans; Idazoxan; Ligands; Mice; Models, Molecular; Molecular Sequence Data; Oxymetazoline; Protein Structure, Tertiary; Quinoxalines; Radioligand Assay; Receptors, Adrenergic, alpha-2; Sequence Homology, Amino Acid; Serine; Transfection; Tritium; Yohimbine | 2000 |
hOGG1 Ser326Cys polymorphism and lung cancer susceptibility.
Topics: Adult; Aged; Aged, 80 and over; Alleles; Carcinoma, Squamous Cell; Case-Control Studies; Cysteine; DNA Damage; Genetic Predisposition to Disease; Guanine; Humans; Japan; Lung Neoplasms; Male; Middle Aged; N-Glycosyl Hydrolases; Polymorphism, Genetic; Risk Assessment; Serine | 1999 |
Identification of the pore-forming region of the outer chloroplast envelope protein OEP16.
Topics: Amines; Amino Acid Substitution; Amino Acids; Chloroplast Proteins; Chloroplasts; Copper; Cysteine; Electrophysiology; Escherichia coli; Ion Channels; Mutagenesis, Site-Directed; Pisum sativum; Plant Proteins; Recombinant Proteins; Serine | 2000 |
A Nedd8 conjugation pathway is essential for proteolytic targeting of p27Kip1 by ubiquitination.
Topics: Amino Acid Substitution; Anaphase-Promoting Complex-Cyclosome; Binding Sites; Catalytic Domain; CDC2-CDC28 Kinases; Cell Cycle Proteins; Cyclin E; Cyclin-Dependent Kinase 2; Cyclin-Dependent Kinase Inhibitor p27; Cyclin-Dependent Kinases; Cysteine; Enzyme Inhibitors; Escherichia coli; HeLa Cells; Humans; Kinetics; Ligases; Microtubule-Associated Proteins; Mutagenesis, Site-Directed; NEDD8 Protein; Phosphorylation; Protein Serine-Threonine Kinases; Recombinant Fusion Proteins; Serine; Tumor Suppressor Proteins; Ubiquitin-Protein Ligase Complexes; Ubiquitin-Protein Ligases; Ubiquitins | 2000 |
Myopathy phenotype of transgenic mice expressing active site-mutated inactive p94 skeletal muscle-specific calpain, the gene product responsible for limb girdle muscular dystrophy type 2A.
Topics: Animals; Binding Sites; Body Weight; Calpain; Connectin; Cysteine; Female; Immunohistochemistry; Mice; Mice, Transgenic; Muscle Proteins; Muscle, Skeletal; Muscular Diseases; Muscular Dystrophies; Mutation; Phenotype; Plasmids; Polymerase Chain Reaction; Protein Kinases; Serine | 2000 |
Roles of two conserved amino acid residues in the active site of galactose-1-phosphate uridylyltransferase: an essential serine and a nonessential cysteine.
Topics: Binding Sites; Circular Dichroism; Cysteine; Escherichia coli; Hydrogen Bonding; Iron; Kinetics; Models, Molecular; Mutagenesis, Site-Directed; Serine; Thermodynamics; UTP-Hexose-1-Phosphate Uridylyltransferase; Zinc | 2000 |
The sucrose permease of Escherichia coli: functional significance of cysteine residues and properties of a cysteine-less transporter.
Topics: Alkylation; Biological Transport, Active; Cysteine; Escherichia coli; Escherichia coli Proteins; Ethylmaleimide; Membrane Transport Modulators; Membrane Transport Proteins; Mutagenesis, Site-Directed; Serine; Sucrose | 2000 |
Functional conservation in the putative substrate binding site of the sucrose permease from Escherichia coli.
Topics: Alkylation; Arginine; Aspartic Acid; Binding Sites; Biological Transport, Active; Chromatography, Affinity; Conserved Sequence; Cysteine; Escherichia coli; Escherichia coli Proteins; Ethylmaleimide; Iodoacetic Acid; Membrane Transport Proteins; Mutagenesis, Site-Directed; Serine; Substrate Specificity; Sucrose | 2000 |
Thermodynamic characterization of mutants of human fibroblast growth factor 1 with an increased physiological half-life.
Topics: Calorimetry, Differential Scanning; Circular Dichroism; Cysteine; Fibroblast Growth Factor 1; Guanidine; Half-Life; Humans; Mutagenesis; Mutation; Protein Denaturation; Protein Folding; Serine; Thermodynamics | 2000 |
Transsulfuration, protein synthesis rate and follicle mRNA in the skin of young Merino lambs in response to infusions of methionine and serine.
Topics: Animals; Carbon Isotopes; Cysteine; Female; Hair Follicle; Methionine; Protein Biosynthesis; RNA, Messenger; Serine; Sheep; Skin; Sulfur; Wool | 2000 |
Site-specific conjugation on serine right-arrow cysteine variant monoclonal antibodies.
Topics: Amino Acid Sequence; Animals; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Chelating Agents; Cross-Linking Reagents; Cysteine; Drug Design; Genetic Variation; Immunoglobulin G; Immunoglobulin Heavy Chains; Mice; Models, Molecular; Molecular Sequence Data; Mutagenesis, Site-Directed; Peptide Mapping; Protein Conformation; Protein Engineering; Serine | 2000 |
Towards models of vanadate-dependent haloperoxidases: the hydroxyl side chain.
Topics: Binding Sites; Cysteine; Homoserine; Hydroxyl Radical; Magnetic Resonance Spectroscopy; Models, Chemical; Models, Molecular; Molecular Structure; Peroxidases; Protein Tyrosine Phosphatases; Serine; Threonine; Tyrosine; Vanadates | 2000 |
Dopamine receptor D2 Ser/Cys 311 variant is associated with delusion and disorganization symptomatology in major psychoses.
Topics: Adult; Amino Acid Substitution; Bipolar Disorder; Cysteine; Depressive Disorder; Female; Genetic Variation; Humans; Male; Middle Aged; Psychotic Disorders; Receptors, Dopamine D2; Reference Values; Schizophrenia; Schizophrenia, Paranoid; Serine | 2000 |
Hepatocyte growth factor-induced differential activation of phospholipase cgamma 1 and phosphatidylinositol 3-kinase is regulated by tyrosine phosphatase SHP-1 in astrocytes.
Topics: Actins; Androstadienes; Animals; Astrocytes; Blotting, Western; Cell Movement; Cells, Cultured; Cysteine; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Estrenes; Genes, Dominant; Hepatocyte Growth Factor; Intracellular Signaling Peptides and Proteins; Isoenzymes; Microscopy, Fluorescence; Mutation; Phosphatidylinositol 3-Kinases; Phosphodiesterase Inhibitors; Phospholipase C gamma; Phosphorylation; Precipitin Tests; Protein Kinase C; Protein Tyrosine Phosphatase, Non-Receptor Type 11; Protein Tyrosine Phosphatase, Non-Receptor Type 6; Protein Tyrosine Phosphatases; Pyrrolidinones; Rats; Rats, Wistar; Recombinant Proteins; Serine; Signal Transduction; Time Factors; Transfection; Type C Phospholipases; Vanadates; Wortmannin | 2000 |
Src homology region 2 (SH2) domain-containing phosphatase-1 dephosphorylates B cell linker protein/SH2 domain leukocyte protein of 65 kDa and selectively regulates c-Jun NH2-terminal kinase activation in B cells.
Topics: Adaptor Proteins, Signal Transducing; Amino Acid Substitution; B-Lymphocytes; Carrier Proteins; Cysteine; Enzyme Activation; Enzyme Precursors; Humans; Intracellular Signaling Peptides and Proteins; JNK Mitogen-Activated Protein Kinases; Ligands; Mitogen-Activated Protein Kinases; Molecular Weight; Phosphoproteins; Phosphorylation; Protein Phosphatase 1; Protein Structure, Tertiary; Protein Tyrosine Phosphatase, Non-Receptor Type 11; Protein Tyrosine Phosphatase, Non-Receptor Type 6; Protein Tyrosine Phosphatases; Protein-Tyrosine Kinases; Receptors, Antigen, B-Cell; Serine; SH2 Domain-Containing Protein Tyrosine Phosphatases; src Homology Domains; src-Family Kinases; Substrate Specificity; Syk Kinase; Transfection; Tumor Cells, Cultured | 2000 |
A structure-function study of a proton transport pathway in the gamma-class carbonic anhydrase from Methanosarcina thermophila.
Topics: Alanine; Amino Acid Substitution; Aspartic Acid; Biological Transport; Carbonic Anhydrases; Cysteine; Deuterium; Escherichia coli; Genetic Variation; Glutamic Acid; Glutamine; Histidine; Hydrogen-Ion Concentration; Kinetics; Lysine; Methanosarcina; Mutagenesis, Site-Directed; Protons; Serine; Solvents; Structure-Activity Relationship; Threonine; Tryptophan | 2000 |
Cysteine residues and the structure of the rat renal proximal tubular type II sodium phosphate cotransporter (rat NaPi IIa).
Topics: Amino Acid Sequence; Amino Acid Substitution; Animals; Carrier Proteins; Cysteine; Disulfides; Ethyl Methanesulfonate; Kidney Tubules, Proximal; Mesylates; Methyl Methanesulfonate; Molecular Sequence Data; Mutagenesis, Site-Directed; Oocytes; Protein Structure, Tertiary; Rats; Reducing Agents; Serine; Sodium-Phosphate Cotransporter Proteins; Sodium-Phosphate Cotransporter Proteins, Type II; Sodium-Phosphate Cotransporter Proteins, Type IIa; Symporters; Xenopus laevis | 2000 |
Structural effects of the active site mutation cysteine to serine in Bacillus cereus zinc-beta-lactamase.
Topics: Bacillus cereus; beta-Lactamases; Catalytic Domain; Crystallography, X-Ray; Cysteine; Hydrogen Bonding; Models, Molecular; Point Mutation; Protein Conformation; Serine; Zinc | 2000 |
Genomic and functional characterization of the oas gene family encoding O-acetylserine (thiol) lyases, enzymes catalyzing the final step in cysteine biosynthesis in Arabidopsis thaliana.
Topics: Arabidopsis; Cell Compartmentation; Cysteine; Cysteine Synthase; DNA, Plant; Evolution, Molecular; Exons; Gene Expression Regulation, Enzymologic; Genes, Plant; Introns; Isoenzymes; Kinetics; Mitochondria; Molecular Sequence Data; Phylogeny; Promoter Regions, Genetic; Protein Binding; Recombinant Fusion Proteins; Sequence Analysis, DNA; Serine; Substrate Specificity | 2000 |
C8/119S mutation of major mite allergen Derf-2 leads to degenerate secondary structure and molecular polymerization and induces potent and exclusive Th1 cell differentiation.
Topics: Adjuvants, Immunologic; Allergens; Amino Acid Substitution; Animals; Antigen Presentation; Antigens, Dermatophagoides; B-Lymphocytes; Cell Differentiation; Clone Cells; Cysteine; Dose-Response Relationship, Immunologic; Epitopes, T-Lymphocyte; Glycoproteins; Humans; Hypersensitivity, Immediate; Lymphocyte Activation; Mites; Mutagenesis, Site-Directed; Protein Structure, Secondary; Serine; Th1 Cells | 2000 |
Serine 121 is an essential amino acid for biotin sulfoxide reductase functionality.
Topics: Alanine; Amino Acid Sequence; Amino Acids; Binding Sites; Biotin; Catalysis; Chromatography, High Pressure Liquid; Coenzymes; Conserved Sequence; Cysteine; Electrophoresis, Polyacrylamide Gel; Escherichia coli; Factor Xa; Glutathione Transferase; Guanine Nucleotides; Iron-Sulfur Proteins; Ligands; Mass Spectrometry; Metalloproteins; Molecular Sequence Data; Molybdenum Cofactors; Mutagenesis, Site-Directed; NADP; Oxidative Stress; Oxidoreductases; Oxygen; Paraquat; Pteridines; Pterins; Recombinant Fusion Proteins; Rhodobacter sphaeroides; Sequence Homology, Amino Acid; Serine; Spectrometry, Fluorescence; Threonine; Time Factors | 2000 |
A family of secreted mucins from the parasitic nematode Toxocara canis bears diverse mucin domains but shares similar flanking six-cysteine repeat motifs.
Topics: Amino Acid Sequence; Animals; Blotting, Western; Chromatography; Chromatography, High Pressure Liquid; Cysteine; DNA, Complementary; Electrophoresis, Polyacrylamide Gel; Expressed Sequence Tags; Female; Gastric Mucins; Gene Library; Models, Biological; Models, Molecular; Molecular Sequence Data; Mucins; Multigene Family; Protein Sorting Signals; Protein Structure, Tertiary; Recombinant Proteins; RNA, Messenger; Sequence Homology, Amino Acid; Serine; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Threonine; Toxocara canis | 2000 |
Mechanism of phosphoanhydride cleavage by baculovirus phosphatase.
Topics: Adenosine Diphosphate; Adenosine Triphosphatases; Alanine; Amino Acid Sequence; Animals; Aspartic Acid; Baculoviridae; Catalysis; Cloning, Molecular; Cysteine; DNA Mutational Analysis; Dose-Response Relationship, Drug; Escherichia coli; Humans; Hydrogen-Ion Concentration; Kinetics; Molecular Sequence Data; Mutagenesis, Site-Directed; Mutation, Missense; Organophosphates; Oxygen; Phosphoric Monoester Hydrolases; Phosphorus; Plasmids; Recombinant Proteins; RNA, Messenger; Sequence Homology, Amino Acid; Serine; Structure-Activity Relationship; Temperature; Time Factors; Transformation, Genetic | 2000 |
Altering the reaction specificity of eukaryotic ornithine decarboxylase.
Topics: Alanine; Animals; Binding Sites; Catalysis; Chromatography, High Pressure Liquid; Crystallography, X-Ray; Cysteine; Decarboxylation; Kinetics; Models, Molecular; Mutagenesis, Site-Directed; Ornithine Decarboxylase; Putrescine; Serine; Spectrometry, Fluorescence; Spectrophotometry, Ultraviolet; Substrate Specificity; Trypanosoma brucei brucei | 2000 |
Mutational analysis of metallo-beta-lactamase CcrA from Bacteroides fragilis.
Topics: Amino Acid Substitution; Asparagine; Aspartic Acid; Bacterial Proteins; Bacteroides fragilis; beta-Lactamases; Cysteine; Deuterium; DNA Mutational Analysis; DNA, Bacterial; Gene Expression Regulation, Bacterial; Hydrogen-Ion Concentration; Kinetics; Metalloproteins; Mutagenesis, Site-Directed; Protons; Recombinant Proteins; Serine; Solvents; Zinc | 2000 |
An alternative protein splicing mechanism for inteins lacking an N-terminal nucleophile.
Topics: Alanine; Alternative Splicing; Bacterial Proteins; Carrier Proteins; Catalysis; Cell Line; Cloning, Molecular; Cysteine; Methanococcus; Models, Genetic; Mutagenesis, Site-Directed; Mutation; Polymorphism, Genetic; Protein Processing, Post-Translational; Recombinant Fusion Proteins; Serine | 2000 |
Effects of bienzyme complex formation of cysteine synthetase from escherichia coli on some properties and kinetics.
Topics: Acetyltransferases; Cysteine; Cysteine Synthase; Dithionitrobenzoic Acid; Escherichia coli; Hydrogen-Ion Concentration; Kinetics; Protein Conformation; Serine; Serine O-Acetyltransferase | 2000 |
Sex differences in allelic frequencies of the 5-HT2C Cys23Ser polymorphism in psychiatric patients and healthy volunteers: findings from an association study.
Topics: Adult; Alcoholism; Alleles; Amino Acid Substitution; Anxiety Disorders; Cysteine; Female; Gene Frequency; Humans; Male; Mental Disorders; Middle Aged; Narcolepsy; Panic Disorder; Polymorphism, Genetic; Receptor, Serotonin, 5-HT2C; Receptors, Serotonin; Reference Values; Serine; Sex Characteristics; X Chromosome | 2000 |
Further evidence supporting the association between the dopamine receptor D2 Ser/Cys311 variant and disorganized symptomatology of schizophrenia.
Topics: Amino Acid Substitution; Cysteine; Genetic Predisposition to Disease; Genetic Variation; Genotype; Humans; Polymorphism, Genetic; Receptors, Dopamine D2; Schizophrenia, Disorganized; Serine | 2000 |
Analysis of the role of conserved cysteine residues in the bcl-2 oncoprotein.
Topics: Amino Acid Substitution; Animals; bcl-2-Associated X Protein; Cell Line; Cell Survival; Conserved Sequence; Cysteine; Dimerization; DNA Fragmentation; Interleukin-3; Ion Channels; Mice; Mutagenesis, Site-Directed; Poly(ADP-ribose) Polymerases; Protein Binding; Protein Processing, Post-Translational; Protein Structure, Tertiary; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Serine; Two-Hybrid System Techniques | 2000 |
Ligand-independent dimerization and activation of the oncogenic Xmrk receptor by two mutations in the extracellular domain.
Topics: Amino Acid Substitution; Animals; Cells, Cultured; Cyprinodontiformes; Cysteine; Dimerization; Fish Proteins; Glycosylation; Humans; Ligands; Mutation; Oncogenes; Protein Structure, Tertiary; Proto-Oncogene Mas; Receptor Protein-Tyrosine Kinases; Serine; Species Specificity | 2001 |
The Escherichia coli PII signal transduction protein regulates the activities of the two-component system transmitter protein NRII by direct interaction with the kinase domain of the transmitter module.
Topics: Bacterial Proteins; Chromatography, Gel; Cross-Linking Reagents; Cysteine; Electrophoresis, Polyacrylamide Gel; Enzyme Activation; Escherichia coli; Fluorobenzenes; Maleimides; Mutagenesis, Site-Directed; Peptide Fragments; Peptide Mapping; Phosphoprotein Phosphatases; Phosphorylation; PII Nitrogen Regulatory Proteins; Protein Kinases; Protein Structure, Tertiary; Serine; Signal Transduction | 2000 |
The extracellular calcium-sensing receptor dimerizes through multiple types of intermolecular interactions.
Topics: Calcium; Cell Line; Cysteine; Dimerization; Disulfides; Humans; Mutation; Protein Structure, Tertiary; Receptors, Calcium-Sensing; Receptors, Cell Surface; Serine; Transfection | 2001 |
The conserved cysteine 7.38 residue is differentially accessible in the binding-site crevices of the mu, delta, and kappa opioid receptors.
Topics: Amino Acid Sequence; Animals; Benzomorphans; Binding Sites; Cell Line; Conserved Sequence; Cysteine; Diprenorphine; Dose-Response Relationship, Drug; Ethyl Methanesulfonate; Glutamic Acid; Humans; Indicators and Reagents; Mesylates; Methionine; Molecular Sequence Data; Mutagenesis, Site-Directed; Naloxone; Narcotic Antagonists; Protein Structure, Secondary; Rats; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Serine; Time Factors; Tritium | 2000 |
Serine and alanine mutagenesis of the nine native cysteine residues of the human A(1) adenosine receptor.
Topics: Alanine; Amino Acid Sequence; Cells, Cultured; Cysteine; Humans; Molecular Sequence Data; Mutagenesis; Protein Conformation; Purinergic P1 Receptor Antagonists; Radioligand Assay; Receptors, Purinergic P1; Serine; Transfection; Tritium; Xanthines | 2000 |
Investigation of iodine-123-labelled amino acid derivatives for imaging cerebral gliomas: uptake in human glioma cells and evaluation in stereotactically implanted C6 glioma rats.
Topics: Alanine; Amino Acids; Amino Acids, Cyclic; Animals; beta-Alanine; Binding, Competitive; Blood-Brain Barrier; Brain Neoplasms; Cysteine; Glioblastoma; Humans; Iodine Radioisotopes; Isoquinolines; Male; Methyltyrosines; Neoplasm Transplantation; Phenylalanine; Radiopharmaceuticals; Rats; Rats, Sprague-Dawley; Rats, Wistar; Serine; Tetrahydroisoquinolines; Tomography, Emission-Computed, Single-Photon; Tumor Cells, Cultured | 2000 |
Reviving a dead enzyme: cytosine deaminations promoted by an inactive DNA methyltransferase and an S-adenosylmethionine analogue.
Topics: Adenosine; Alanine; Cysteine; Cytosine; Deamination; DNA (Cytosine-5-)-Methyltransferases; DNA-Cytosine Methylases; Enzyme Inhibitors; Escherichia coli; Mutagenesis, Site-Directed; S-Adenosylmethionine; Serine; Uracil | 2000 |
A de novo adrenoleukodystrophy gene (ABCD1) mutation S636I without detectable ABCD1 protein and a R104C mutation with normal amounts of protein from an Austrian patient collective.
Topics: Adrenal Insufficiency; Adrenoleukodystrophy; Adult; Amino Acid Substitution; Arginine; ATP Binding Cassette Transporter, Subfamily D; ATP Binding Cassette Transporter, Subfamily D, Member 1; ATP-Binding Cassette Transporters; Cysteine; Humans; Isoleucine; Mutation, Missense; Proteins; Serine | 2000 |
Disulfide bond in Pseudomonas aeruginosa lipase stabilizes the structure but is not required for interaction with its foldase.
Topics: Biological Transport; Cysteine; Disulfides; Enzyme Stability; Interleukin-6; Leukemia Inhibitory Factor; Lipase; Molecular Chaperones; Mutagenesis, Site-Directed; Oxidation-Reduction; Protein Binding; Protein Conformation; Protein Folding; Proteins; Pseudomonas aeruginosa; Serine | 2001 |
N-terminal sequence analysis of bovine dentin phosphophoryn after conversion of phosphoseryl to S-propylcysteinyl residues.
Topics: Amino Acid Motifs; Amino Acid Sequence; Animals; Cattle; Chromatography, Ion Exchange; Cysteine; Dentin; Electrophoresis, Polyacrylamide Gel; Mass Spectrometry; Molecular Sequence Data; Molecular Weight; Phosphoproteins; Phosphorylation; Protein Subunits; Sequence Analysis, Protein; Serine | 2000 |
Distinct functions of the two protein tyrosine phosphatase domains of LAR (leukocyte common antigen-related) on tyrosine dephosphorylation of insulin receptor.
Topics: Animals; Binding Sites; COS Cells; Cysteine; Gene Deletion; Immunoblotting; Immunosorbent Techniques; Insulin; Mutagenesis; Phosphorylation; Phosphotyrosine; Polymerase Chain Reaction; Protein Structure, Tertiary; Protein Tyrosine Phosphatases; Receptor-Like Protein Tyrosine Phosphatases, Class 4; Receptor, Insulin; Receptors, Cell Surface; Serine; Structure-Activity Relationship; Substrate Specificity; Transfection | 2001 |
Electrogenic Na(+)-dependent L-alanine transport in the lizard duodenum. Involvement of systems A and ASC.
Topics: Alanine; Animals; beta-Alanine; Biological Transport; Carrier Proteins; Cysteine; Duodenum; Electric Conductivity; Epithelium; Intestinal Mucosa; Kinetics; Lizards; Membrane Potentials; Serine; Sodium | 2001 |
Mutagenesis of the regulatory domain of phenylalanine hydroxylase.
Topics: Amino Acid Sequence; Amino Acid Substitution; Animals; Binding Sites; Cysteine; Gene Expression; Humans; Kinetics; Molecular Sequence Data; Mutagenesis, Site-Directed; Phenylalanine; Phenylalanine Hydroxylase; Rats; Serine | 2001 |
A Ser(365)-->Cys mutation of fibroblast growth factor receptor 3 in mouse downregulates Ihh/PTHrP signals and causes severe achondroplasia.
Topics: Achondroplasia; Animals; Base Sequence; Cell Differentiation; Cell Division; Chondrocytes; Cysteine; DNA Primers; Down-Regulation; Fibroblast Growth Factor 2; Gene Expression Regulation; Growth Plate; Hedgehog Proteins; In Situ Hybridization; Mice; Mutagenesis, Site-Directed; Parathyroid Hormone-Related Protein; Protein-Tyrosine Kinases; Proteins; Receptor, Fibroblast Growth Factor, Type 3; Receptors, Fibroblast Growth Factor; Serine; Signal Transduction; Trans-Activators | 2001 |
Expression, activity and cytotoxicity of pertussis toxin S1 subunit in transfected mammalian cells.
Topics: Adenosine Diphosphate Ribose; Animals; Bordetella pertussis; CHO Cells; COS Cells; Cricetinae; Cysteine; Eukaryotic Cells; GTP-Binding Proteins; Mutation; Pertussis Toxin; Protein Processing, Post-Translational; Protein Sorting Signals; Recombinant Fusion Proteins; Serine; Transfection; Virulence Factors, Bordetella | 2001 |
Helix packing in the lactose permease of Escherichia coli: distances between site-directed nitroxides and a lanthanide.
Topics: Binding Sites; Chelating Agents; Cyclic N-Oxides; Cysteine; Electron Spin Resonance Spectroscopy; Escherichia coli; Escherichia coli Proteins; Gadolinium; Heterocyclic Compounds; Isoleucine; Membrane Transport Proteins; Mesylates; Metals, Rare Earth; Monoiodotyrosine; Monosaccharide Transport Proteins; Mutagenesis, Site-Directed; Nitrobenzenes; Protein Structure, Secondary; Serine; Spin Labels; Symporters; Tyrosine | 2001 |
Role for cysteine residues in the in vivo folding and assembly of the phage P22 tailspike.
Topics: Adhesins, Bacterial; Bacteriophage P22; Cloning, Molecular; Cysteine; Disulfides; Electrophoresis, Polyacrylamide Gel; Escherichia coli; Kinetics; Models, Molecular; Mutagenesis, Site-Directed; Oxygen; Protein Conformation; Protein Folding; Serine; Temperature; Time Factors | 2001 |
Distinct cysteine sulfhydryl environments detected by analysis of Raman S-hh markers of Cys-->Ser mutant proteins.
Topics: Amino Acid Substitution; Bacteriophage P22; Circular Dichroism; Crystallography, X-Ray; Cysteine; Disulfides; Glycoside Hydrolases; Hydrogen Bonding; Mass Spectrometry; Models, Molecular; Mutation; Protein Conformation; Protein Folding; Recombinant Proteins; Salmonella typhimurium; Serine; Spectrometry, Fluorescence; Spectrum Analysis, Raman; Viral Tail Proteins | 2001 |
Identification of functionally important cysteine residues of the human renin-binding protein as the enzyme N-acetyl-D-glucosamine 2-epimerase.
Topics: Amino Acid Sequence; Amino Acid Substitution; Animals; Binding Sites; Blotting, Western; Carbohydrate Epimerases; Carrier Proteins; Catalysis; Cyanobacteria; Cysteine; Escherichia coli; Humans; Molecular Sequence Data; Multienzyme Complexes; Rats; Recombinant Proteins; Restriction Mapping; Sequence Alignment; Sequence Deletion; Serine; Structure-Activity Relationship; Swine | 2001 |
Substrate-induced activation of a trapped IMC-mediated protein folding intermediate.
Topics: Binding Sites; Chromatography, Gel; Circular Dichroism; Cysteine; Disulfides; Enzyme Activation; Methionine; Models, Molecular; Molecular Chaperones; Mutation; Protein Conformation; Protein Denaturation; Protein Folding; Protein Precursors; Protein Renaturation; Serine; Subtilisin | 2001 |
Structure-function analysis of the zinc-binding region of the Clpx molecular chaperone.
Topics: Adenosine Triphosphatases; Adenosine Triphosphate; ATPases Associated with Diverse Cellular Activities; Binding Sites; Cations; Chromatography; Circular Dichroism; Cloning, Molecular; Cysteine; Dose-Response Relationship, Drug; Endopeptidase Clp; Enzyme-Linked Immunosorbent Assay; Escherichia coli; Escherichia coli Proteins; Hydrolysis; Kinetics; Molecular Chaperones; Mutagenesis, Site-Directed; Plasmids; Protein Binding; Protein Denaturation; Serine; Spectrophotometry; Spectrophotometry, Infrared; Structure-Activity Relationship; Zinc; Zinc Fingers | 2001 |
Phosphorylation of the protein kinase mutated in Peutz-Jeghers cancer syndrome, LKB1/STK11, at Ser431 by p90(RSK) and cAMP-dependent protein kinase, but not its farnesylation at Cys(433), is essential for LKB1 to suppress cell vrowth.
Topics: AMP-Activated Protein Kinase Kinases; AMP-Activated Protein Kinases; Animals; Binding Sites; Calcium-Calmodulin-Dependent Protein Kinases; Cell Division; Cell Line; Cloning, Molecular; Colforsin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Cysteine; Enzyme Activation; Enzyme Inhibitors; Epidermal Growth Factor; Glutathione Transferase; Humans; Immunoblotting; Isoquinolines; Mevalonic Acid; Mice; Models, Biological; Mutation; Peutz-Jeghers Syndrome; Phosphorylation; Precipitin Tests; Protein Prenylation; Protein Serine-Threonine Kinases; Rats; Ribosomal Protein S6 Kinases; Ribosomal Protein S6 Kinases, 90-kDa; Serine; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Sulfonamides; Time Factors; Transfection | 2001 |
Molecular dynamics study of Ca(2+) binding loop variants of parvalbumin with modifications at the "gateway" position.
Topics: Amino Acid Substitution; Animals; Arginine; Binding Sites; Cadmium; Calcium; Computer Simulation; Cysteine; EF Hand Motifs; Fishes; Genetic Variation; Models, Chemical; Models, Molecular; Mutation; Parvalbumins; Peptide Fragments; Protein Binding; Protein Conformation; Protein Folding; Protein Isoforms; Protein Structure, Tertiary; Serine; Temperature; Thermodynamics; Time Factors | 2001 |
Inactivation of pyruvate formate-lyase by dioxygen: defining the mechanistic interplay of glycine 734 and cysteine 419 by rapid freeze-quench EPR.
Topics: Acetylation; Acetyltransferases; Alanine; Cysteine; Electron Spin Resonance Spectroscopy; Enzyme Activation; Escherichia coli; Free Radicals; Freezing; Glycine; Mutagenesis, Site-Directed; Oxygen; Peroxides; Serine | 2001 |
Ser326Cys polymorphism in hOGG1 gene and risk of esophageal cancer in a Chinese population.
Topics: Amino Acid Substitution; Asian People; Cysteine; DNA-Formamidopyrimidine Glycosylase; Esophageal Neoplasms; Female; Genetic Predisposition to Disease; Humans; Male; Middle Aged; N-Glycosyl Hydrolases; Polymorphism, Genetic; Risk Factors; Serine | 2001 |
Consequences of a modified putative substrate-activation site on catalysis by yeast pyruvate decarboxylase.
Topics: Alanine; Catalysis; Cysteine; Deuterium Oxide; Enzyme Activation; Hydrogen; Kinetics; Models, Chemical; Pyruvate Decarboxylase; Recombinant Proteins; Saccharomyces cerevisiae; Serine; Solvents; Substrate Specificity; Thiamine Pyrophosphate; Thiazoles | 2001 |
Mutational analyses of cysteine residues of bovine dihydrodiol dehydrogenase 3.
Topics: Animals; Cattle; Cysteine; DNA Mutational Analysis; Escherichia coli; Liver; Molecular Sequence Data; Mutagenesis, Site-Directed; Oxidoreductases; Recombinant Proteins; Serine; Substrate Specificity | 2001 |
Effects of cysteine to serine substitutions in the two inter-chain disulfide bonds of insulin.
Topics: Amino Acid Substitution; Animals; Circular Dichroism; Cysteine; Disulfides; Humans; Insulin; Mice; Mice, Inbred ICR; Mutagenesis, Site-Directed; Proinsulin; Protein Folding; Receptor, Insulin; Serine; Swine | 2001 |
Structures of tryparedoxins revealing interaction with trypanothione.
Topics: Amino Acid Sequence; Animals; Catalytic Domain; Crithidia fasciculata; Crystallography, X-Ray; Cysteine; Glutathione; Models, Molecular; Molecular Sequence Data; Mutagenesis, Site-Directed; Protein Conformation; Sequence Homology, Amino Acid; Serine; Spermidine; Thioredoxins | 2001 |
The structure of a zeta class glutathione S-transferase from Arabidopsis thaliana: characterisation of a GST with novel active-site architecture and a putative role in tyrosine catabolism.
Topics: Amino Acid Sequence; Arabidopsis; Binding Sites; Catalysis; Crystallography, X-Ray; Cysteine; Dimerization; Glutathione; Glutathione Transferase; Kinetics; Models, Molecular; Molecular Sequence Data; Mutagenesis, Site-Directed; Mutation; Protein Structure, Quaternary; Protein Structure, Tertiary; Protein Subunits; Sequence Alignment; Serine; Tyrosine | 2001 |
Identification of essential cysteine residues in 3-deoxy-D-arabino-heptulosonate-7-phosphate synthase from Corynebacterium glutamicum.
Topics: 3-Deoxy-7-Phosphoheptulonate Synthase; Amino Acid Sequence; Catalytic Domain; Corynebacterium; Cysteine; Kinetics; Molecular Sequence Data; Mutagenesis, Site-Directed; Mutation; Recombinant Proteins; Serine | 2001 |
Cysteine mutagenesis reveals novel structure-function features within the predicted third extracellular loop of the type IIa Na(+)/P(i) cotransporter.
Topics: Carrier Proteins; Cysteine; DNA, Complementary; Forecasting; Hydrogen-Ion Concentration; Mutagenesis, Site-Directed; Patch-Clamp Techniques; Serine; Sodium-Phosphate Cotransporter Proteins; Structure-Activity Relationship; Symporters | 2001 |
The predicted beta12-beta13 loop is important for inhibition of PP2Acalpha by the antitumor drug fostriecin.
Topics: Alkenes; Amino Acid Sequence; Amino Acid Substitution; Antineoplastic Agents; Cysteine; Humans; Molecular Sequence Data; Phosphoprotein Phosphatases; Polyenes; Protein Structure, Secondary; Pyrones; Saccharomyces cerevisiae; Sequence Homology, Amino Acid; Serine | 2001 |
Role of the cystine-knot motif at the C-terminus of rat mucin protein Muc2 in dimer formation and secretion.
Topics: Animals; Base Sequence; Cysteine; Cystine; Dimerization; Disulfides; DNA Primers; Mucin-2; Mucins; Mutagenesis, Site-Directed; Rats; Recombinant Proteins; Serine | 2001 |
Arylisothiocyanate-containing esters of caffeic acid designed as affinity ligands for HIV-1 integrase.
Topics: Amino Acid Substitution; Base Sequence; Caffeic Acids; Cysteine; Esters; HIV Integrase; HIV Long Terminal Repeat; HIV-1; Isothiocyanates; Ligands; Magnetic Resonance Spectroscopy; Oligodeoxyribonucleotides; Serine; Spectrometry, Mass, Fast Atom Bombardment | 2001 |
X-ray crystalline structures of pyrrolidone carboxyl peptidase from a hyperthermophile, Pyrococcus furiosus, and its cys-free mutant.
Topics: Amino Acid Sequence; Bacillus; Binding Sites; Crystallography, X-Ray; Cysteine; Enzyme Stability; Models, Molecular; Molecular Sequence Data; Mutation; Protein Structure, Quaternary; Protein Structure, Secondary; Protein Subunits; Pyrococcus furiosus; Pyroglutamyl-Peptidase I; Sequence Homology, Amino Acid; Serine; Static Electricity; Thermococcus; Thermodynamics | 2001 |
Dihydrooxonate is a substrate of dihydroorotate dehydrogenase (DHOD) providing evidence for involvement of cysteine and serine residues in base catalysis.
Topics: Binding Sites; Catalysis; Cysteine; Dihydroorotate Dehydrogenase; Escherichia coli; Fumarates; Lactobacillus; Mutation; Orotic Acid; Oxidoreductases; Oxidoreductases Acting on CH-CH Group Donors; Recombinant Proteins; Serine; Substrate Specificity | 2001 |
Studies on analogs of a peptide derived from alpha-fetoprotein having antigrowth properties.
Topics: Alanine; alpha-Fetoproteins; Animals; Antineoplastic Agents; Chromatography, Gel; Cysteine; Dose-Response Relationship, Drug; Epitopes; Estrogens; Female; Glycine; Humans; Hydrogen-Ion Concentration; Mice; Peptides; Protein Structure, Secondary; Serine; Time Factors; Uterus | 2001 |
Mutagenesis of beta-tubulin cysteine residues in Saccharomyces cerevisiae: mutation of cysteine 354 results in cold-stable microtubules.
Topics: Alanine; Benomyl; Cold Temperature; Cysteine; Fungal Proteins; Fungicides, Industrial; Microtubules; Mutagenesis, Site-Directed; Protein Structure, Secondary; Saccharomyces cerevisiae; Serine; Tubulin | 2001 |
A PDZ domain protein interacts with the C-terminal tail of the insulin-like growth factor-1 receptor but not with the insulin receptor.
Topics: 3T3 Cells; Alternative Splicing; Amino Acid Sequence; Animals; Binding Sites; Carrier Proteins; Cell Division; Cell Movement; Cloning, Molecular; Cysteine; DNA, Complementary; Gene Deletion; Gene Library; Glutathione Transferase; Humans; Immunoblotting; Jurkat Cells; Mice; Microscopy, Fluorescence; Molecular Sequence Data; Mutagenesis; Phosphorylation; Precipitin Tests; Protein Binding; Protein Structure, Tertiary; Receptor, IGF Type 1; Receptor, Insulin; Serine; Signal Transduction; Threonine; Transfection; Tumor Cells, Cultured; Two-Hybrid System Techniques | 2001 |
Redox thermodynamics of mutant forms of the rubredoxin from Clostridiumpasteurianum: identification of a stable Fe(III)(S-Cys)3(OH) centre in the C6S mutant.
Topics: Clostridium; Cysteine; Models, Molecular; Mutation; Oxidation-Reduction; Protein Conformation; Recombinant Proteins; Rubredoxins; Serine; Thermodynamics | 2001 |
The role of amino acids in the regulation of hydrogen sulfide production during ultradian respiratory oscillation of Saccharomyces cerevisiae.
Topics: Aerobiosis; Amino Acids; Biological Clocks; Cell Respiration; Culture Media; Cysteine; Homoserine; Hydrogen Sulfide; Methionine; Oscillometry; Periodicity; Saccharomyces cerevisiae; Serine; Sulfur Compounds; Threonine | 2001 |
An alternative pathway for metabolism of leukotriene D(4): effects on contractions to cysteinyl-leukotrienes in the guinea-pig trachea.
Topics: Animals; Borates; Cysteine; Dicarboxylic Acids; Dose-Response Relationship, Drug; Glutathione; Guinea Pigs; In Vitro Techniques; Indazoles; Leukotriene Antagonists; Leukotriene C4; Leukotriene D4; Leukotriene E4; Leukotrienes; Male; Membrane Proteins; Muscle Contraction; Propionates; Quinolines; Receptors, Leukotriene; Serine; SRS-A; Trachea | 2001 |
Extracellular Toll-like receptor 2 region containing Ser40-Ile64 but not Cys30-Ser39 is critical for the recognition of Staphylococcus aureus peptidoglycan.
Topics: Amino Acid Sequence; Base Sequence; Cell Line; Cysteine; DNA Primers; Drosophila Proteins; Humans; Isoleucine; Lipopolysaccharide Receptors; Membrane Glycoproteins; Molecular Sequence Data; Mutagenesis; NF-kappa B; Peptidoglycan; Receptors, Cell Surface; Recombinant Fusion Proteins; Reverse Transcriptase Polymerase Chain Reaction; Serine; Signal Transduction; Staphylococcus aureus; Toll-Like Receptor 2; Toll-Like Receptors | 2001 |
Variability of 5-HT2C receptor cys23ser polymorphism among European populations and vulnerability to affective disorder.
Topics: Amino Acid Substitution; Bipolar Disorder; Cysteine; Depressive Disorder; Ethnicity; Europe; Female; Gene Frequency; Genetic Linkage; Genetic Predisposition to Disease; Genetic Variation; Humans; Israel; Least-Squares Analysis; Likelihood Functions; Male; Polymorphism, Genetic; Receptor, Serotonin, 5-HT2C; Receptors, Serotonin; Reference Values; Serine; White People | 2001 |
Characterization of loops of the yeast mitochondrial ADP/ATP carrier facing the cytosol by site-directed mutagenesis.
Topics: Adenosine Diphosphate; Alanine; Anti-Bacterial Agents; Blotting, Western; Bongkrekic Acid; Cell Division; Cysteine; Cytosol; DNA; DNA Primers; Electrophoresis, Polyacrylamide Gel; Eosine Yellowish-(YS); Fluorescent Dyes; Mitochondria; Mitochondrial ADP, ATP Translocases; Models, Biological; Mutagenesis, Site-Directed; Mutation; Protein Structure, Tertiary; Protein Transport; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Serine | 2001 |
Benzamide bioisosteres incorporating dihydroheteroazole substructures: EPC synthesis and SAR leading to a selective dopamine D4 receptor partial agonist (FAUC 179).
Topics: Animals; Biochemistry; Cattle; CHO Cells; Clozapine; Cricetinae; Cysteine; Dopamine Antagonists; Drug Design; Humans; In Vitro Techniques; Indoles; Magnetic Resonance Spectroscopy; Molecular Structure; Quinpirole; Receptors, Dopamine D2; Receptors, Dopamine D4; Serine; Spiperone; Stereoisomerism; Structure-Activity Relationship; Threonine | 2001 |
Comprehensive survey of proteins targeted by chloroplast thioredoxin.
Topics: Amino Acid Sequence; Amino Acid Substitution; Arabidopsis; Binding Sites; Chloroplasts; Cloning, Molecular; Cyclophilins; Cysteine; Disulfides; Glutamate-Ammonia Ligase; Glyceraldehyde-3-Phosphate Dehydrogenases; Kinetics; Models, Molecular; Molecular Sequence Data; Mutagenesis, Site-Directed; Peroxidases; Peroxiredoxins; Phosphoric Monoester Hydrolases; Plant Proteins; Protein Structure, Secondary; Protein Subunits; Recombinant Proteins; Resins, Plant; Ribulose-Bisphosphate Carboxylase; Serine; Spinacia oleracea; Thioredoxins | 2001 |
Methylmercury inhibits cysteine uptake in cultured primary astrocytes, but not in neurons.
Topics: Animals; Animals, Newborn; Aspartic Acid; Astrocytes; Carrier Proteins; Cells, Cultured; Central Nervous System; Cysteine; Dose-Response Relationship, Drug; Excitatory Amino Acid Transporter 1; Fetus; Glutathione; Mercury Poisoning, Nervous System; Methylmercury Compounds; Neurons; Neurotoxins; Rats; Rats, Sprague-Dawley; Serine; Sodium | 2001 |
Identification of sequences within the gamma-carboxylase that represent a novel contact site with vitamin K-dependent proteins and that are required for activity.
Topics: Amino Acid Sequence; Amino Acids; Animals; Baculoviridae; Binding Sites; Blotting, Western; Carbon-Carbon Ligases; Catalysis; Catalytic Domain; Cell Line; Cysteine; DNA, Complementary; Electrophoresis, Polyacrylamide Gel; Humans; Hydrogen-Ion Concentration; Insecta; Ions; Kinetics; Molecular Sequence Data; Mutagenesis, Site-Directed; Peptides; Phenylalanine; Protein Binding; Protein Precursors; Protein Structure, Tertiary; Prothrombin; Rabbits; Recombinant Proteins; Sequence Homology, Amino Acid; Serine; Tyrosine; Vitamin K | 2001 |
Lipoprotein sorting signals evaluated as the LolA-dependent release of lipoproteins from the cytoplasmic membrane of Escherichia coli.
Topics: Aspartic Acid; Cell Division; Cell Membrane; Cysteine; Cytoplasm; DNA Primers; Dose-Response Relationship, Drug; Electrophoresis, Polyacrylamide Gel; Escherichia coli; Escherichia coli Proteins; Lipoproteins; Periplasmic Binding Proteins; Plasmids; Precipitin Tests; Protein Binding; Protein Structure, Tertiary; Protein Transport; Serine | 2001 |
Cysteine 144 in the third transmembrane domain of the creatine transporter is located close to a substrate-binding site.
Topics: Amino Acid Sequence; Animals; Binding Sites; Biological Transport; Biotinylation; Cattle; Cell Line; Chlorine; Creatine; Cysteine; Dose-Response Relationship, Drug; Ethyl Methanesulfonate; Humans; Indicators and Reagents; Ions; Kinetics; Membrane Transport Proteins; Mesylates; Molecular Sequence Data; Mutagenesis, Site-Directed; Mutation; Protein Binding; Protein Conformation; Protein Structure, Tertiary; Rabbits; Rats; Sequence Homology, Amino Acid; Serine; Sodium; Transfection | 2001 |
Role of conservative residue Cys158 in the formation of an active photoprotein complex of obelin.
Topics: Alanine; Amino Acid Sequence; Amino Acid Substitution; Apoproteins; Conserved Sequence; Cysteine; Kinetics; Luminescent Measurements; Luminescent Proteins; Recombinant Proteins; Serine | 2001 |
The 5-hydroxytryptamine(4a) receptor is palmitoylated at two different sites, and acylation is critically involved in regulation of receptor constitutive activity.
Topics: Acylation; Amino Acid Sequence; Animals; Binding Sites; Binding, Competitive; Cell Line; Cell Membrane; COS Cells; Cyclic AMP; Cysteine; DNA; Dose-Response Relationship, Drug; Guanosine 5'-O-(3-Thiotriphosphate); Immunohistochemistry; Insecta; Models, Biological; Molecular Sequence Data; Mutagenesis, Site-Directed; Mutation; Palmitic Acid; Palmitic Acids; Precipitin Tests; Protein Binding; Protein Structure, Tertiary; Receptors, Serotonin; Receptors, Serotonin, 5-HT4; Recombinant Proteins; Sequence Homology, Amino Acid; Serine; Signal Transduction; Time Factors; Transfection | 2002 |
Enhanced crystallization of the Cys18 to Ser mutant of bovine gammaB crystallin.
Topics: Amino Acid Substitution; Animals; Cataract; Cattle; Crystallins; Crystallization; Crystallography, X-Ray; Cysteine; gamma-Crystallins; Kinetics; Models, Molecular; Point Mutation; Protein Conformation; Recombinant Proteins; Serine; Solubility; Thermodynamics | 2001 |
Detailed characterization of cysteine-less P-glycoprotein reveals subtle pharmacological differences in function from wild-type protein.
Topics: Adenosine Triphosphatases; Adenosine Triphosphate; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Azides; Baculoviridae; Binding Sites; Cell Membrane; Cells, Cultured; Cross-Linking Reagents; Cysteine; Dihydropyridines; Dose-Response Relationship, Drug; Drug Resistance, Multiple; Humans; Inhibitory Concentration 50; Kinetics; Mutagenesis; Nicardipine; Photoaffinity Labels; Serine; Spodoptera; Vinblastine | 2001 |
Disulfide bond assignments of secreted Frizzled-related protein-1 provide insights about Frizzled homology and netrin modules.
Topics: Amino Acid Sequence; Animals; Asparagine; Binding Sites; Chromatography, High Pressure Liquid; Cysteine; Cystine; Disulfides; Electrophoresis, Polyacrylamide Gel; Frizzled Receptors; Glycosylation; Heparin; Humans; Lysine; Mass Spectrometry; Mice; Molecular Sequence Data; Mutagenesis, Site-Directed; Netrin Receptors; Phenylalanine; Protein Binding; Protein Structure, Tertiary; Proteins; Receptors, Cell Surface; Recombinant Proteins; Sequence Homology, Amino Acid; Serine; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Subtilisin; Time Factors; Xenopus | 2002 |
Adjacent cysteine residues as a redox switch.
Topics: Alanine; Amino Acid Sequence; Catalysis; Cysteine; Disulfides; Molecular Sequence Data; Mutagenesis, Site-Directed; Oxidation-Reduction; Oxygen; Plasmids; Protein Conformation; Ribonuclease, Pancreatic; Sequence Homology, Amino Acid; Serine | 2001 |
Hemoglobin Porto Alegre forms a tetramer of tetramers superstructure.
Topics: Chromatography, Gel; Cysteine; Dimerization; Disulfides; Hemoglobins, Abnormal; Humans; Kinetics; Microscopy, Electron; Models, Molecular; Mutagenesis, Site-Directed; Mutation; Protein Conformation; Protein Denaturation; Protein Structure, Quaternary; Protein Structure, Secondary; Serine; Spectrometry, Mass, Electrospray Ionization; Time Factors | 2002 |
Engineering of an intersubunit disulfide bridge in the iron-superoxide dismutase of Mycobacterium tuberculosis.
Topics: Cloning, Molecular; Crystallography, X-Ray; Cysteine; Dimerization; Disulfides; Electrophoresis, Polyacrylamide Gel; Guanidine; Guanine; Models, Molecular; Mutagenesis, Site-Directed; Mutation; Mycobacterium tuberculosis; Protein Denaturation; Protein Structure, Quaternary; Serine; Superoxide Dismutase; Thermodynamics | 2002 |
EPR-detected folding kinetics of externally located cysteine-directed spin-labeled mutants of iso-1-cytochrome c.
Topics: Circular Dichroism; Cysteine; Cytochrome c Group; Cytochromes c; Electron Spin Resonance Spectroscopy; Isoenzymes; Kinetics; Mass Spectrometry; Mutagenesis, Site-Directed; Protein Folding; Recombinant Proteins; Saccharomyces cerevisiae Proteins; Serine; Spin Labels | 2001 |
Methylated mono- and di(ethylene glycol)-functionalized beta-sheet forming polypeptides.
Topics: Buffers; Circular Dichroism; Cysteine; Hydrogen-Ion Concentration; Molecular Structure; Peptides; Protein Structure, Secondary; Serine; Solubility; Solutions; Temperature | 2001 |
Vaccinia virus G4L glutaredoxin is an essential intermediate of a cytoplasmic disulfide bond pathway required for virion assembly.
Topics: Alkylation; Amino Acid Substitution; Animals; Cell Line; Chlorocebus aethiops; Cysteine; Cytoplasm; Disulfides; Genetic Complementation Test; Glutaredoxins; Open Reading Frames; Oxidation-Reduction; Oxidoreductases; Proteins; Serine; Vaccinia virus; Viral Plaque Assay; Viral Proteins; Virus Assembly | 2002 |
Cytoplasmic vestibule of the weak inward rectifier Kir6.2 potassium channel.
Topics: Adenosine Triphosphate; Animals; Cells, Cultured; COS Cells; Cysteine; Cytoplasm; DNA, Complementary; Dose-Response Relationship, Drug; Ethyl Methanesulfonate; Immunohistochemistry; Isoleucine; Mesylates; Models, Biological; Models, Chemical; Mutagenesis, Site-Directed; Naphthalenesulfonates; Patch-Clamp Techniques; Potassium; Potassium Channels, Inwardly Rectifying; Protein Binding; Protein Conformation; Protein Structure, Tertiary; Recombinant Fusion Proteins; Serine; Spermine; Sulfhydryl Reagents; Transfection | 2002 |
Essential hydrophilic carboxyl-terminal regions including cysteine residues of the yeast stretch-activated calcium-permeable channel Mid1.
Topics: Alanine; Alleles; Asparagine; Binding Sites; Calcium; Calcium Channels; Codon; Codon, Nonsense; Cysteine; Fungal Proteins; Hydroxylamine; Immunoblotting; Membrane Glycoproteins; Mutagenesis; Mutagenesis, Site-Directed; Mutation; Phosphorylation; Plasmids; Protein Binding; Protein Conformation; Protein Structure, Tertiary; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Serine; Threonine; Time Factors; Tryptophan; Two-Hybrid System Techniques | 2002 |
Escherichia coli B gamma-glutamylcysteine synthetase: modification, purification, crystallization and preliminary crystallographic analysis.
Topics: Crystallization; Crystallography, X-Ray; Cysteine; Escherichia coli; Glutamate-Cysteine Ligase; Maleimides; Mutation; Protein Conformation; Serine; Sulfhydryl Compounds | 2002 |
Mechanisms of regulation of phospholipase D1 and D2 by the heterotrimeric G proteins G13 and Gq.
Topics: Animals; Brain; Clostridium botulinum; COS Cells; Cysteine; DNA-Binding Proteins; Enzyme Activation; Genes, Dominant; GTP-Binding Protein alpha Subunits, G12-G13; GTP-Binding Protein alpha Subunits, Gq-G11; Heterotrimeric GTP-Binding Proteins; Mutation; Palmitic Acid; Phorbol Esters; Phospholipase D; Phosphorylation; Plasmids; Protein Binding; Protein Kinase C; Protein Processing, Post-Translational; Rats; rhoA GTP-Binding Protein; Serine; Threonine; Transfection | 2002 |
Characterization of the methionine sulfoxide reductase activities of PILB, a probable virulence factor from Neisseria meningitidis.
Topics: Amino Acid Sequence; Bacterial Proteins; Binding Sites; Catalysis; Cysteine; Disulfides; Kinetics; Mass Spectrometry; Methionine; Methionine Sulfoxide Reductases; Molecular Sequence Data; Mutagenesis, Site-Directed; Neisseria meningitidis; Oxidoreductases; Plasmids; Protein Binding; Protein Conformation; Protein Folding; Protein Structure, Tertiary; Sequence Homology, Amino Acid; Serine; Spectrophotometry; Sulfenic Acids; Thioredoxins | 2002 |
Importance of Na,K-ATPase residue alpha 1-Arg544 in the segment Arg544-Asp567 for high-affinity binding of ATP, ADP, or MgATP.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Alanine; Amino Acid Substitution; Animals; Arginine; Asparagine; Aspartic Acid; Binding Sites; Conserved Sequence; Cysteine; Glutamic Acid; Magnesium; Mutagenesis, Site-Directed; Peptide Fragments; Phosphorylation; Saccharomyces cerevisiae; Serine; Sodium-Potassium-Exchanging ATPase; Swine; Thermodynamics | 2002 |
Expression of Sorsby's fundus dystrophy mutations in human retinal pigment epithelial cells reduces matrix metalloproteinase inhibition and may promote angiogenesis.
Topics: Animals; Cell Adhesion; Cell Division; Cell Line; Cell Movement; Cells, Cultured; Chick Embryo; Collagen; Cysteine; Drug Combinations; Epithelial Cells; Genes, Dominant; Humans; Immunoblotting; Laminin; Macular Degeneration; Matrix Metalloproteinase Inhibitors; Mutation; Neovascularization, Physiologic; Phenotype; Pigment Epithelium of Eye; Proteoglycans; Retina; Serine; Tissue Inhibitor of Metalloproteinase-3; Transfection | 2002 |
Chorismate lyase: kinetics and engineering for stability.
Topics: Anthranilate Synthase; Binding Sites; Chorismate Mutase; Cysteine; Enzyme Stability; Escherichia coli; Kinetics; Oxo-Acid-Lyases; Parabens; Protein Engineering; Serine; Solubility; Ubiquinone | 2002 |
Regioselective and stereoselective nucleophilic ring opening reactions of a phenyl-substituted aziridine: enantioselective synthesis of beta-substituted tryptophan, cysteine, and serine derivatives.
Topics: Amino Acids; Aziridines; Benzene Derivatives; Catalysis; Chromatography, Thin Layer; Cyclization; Cysteine; Magnetic Resonance Spectroscopy; Mass Spectrometry; Molecular Structure; Phenylalanine; Serine; Stereoisomerism; Tryptophan | 2002 |
Modulation of cyanoalanine synthase and O-acetylserine (thiol) lyases A and B activity by beta-substituted alanyl and anion inhibitors.
Topics: Alanine; Allosteric Regulation; Allosteric Site; Anions; Carbon-Oxygen Lyases; Cysteine; Cysteine Synthase; Dimerization; Homocysteine; Hydrogen Bonding; Intracellular Membranes; Isoenzymes; Kinetics; Lyases; Mitochondria; Models, Biological; Multienzyme Complexes; Potassium Cyanide; Saccharomyces cerevisiae Proteins; Serine; Spinacia oleracea | 2002 |
Structure of a Cys25-->Ser mutant of human cathepsin S.
Topics: Amino Acid Substitution; Cathepsins; Crystallization; Crystallography, X-Ray; Cysteine; Humans; Models, Molecular; Mutation; Protein Conformation; Recombinant Proteins; Serine | 2002 |
Crystal structure of the human estrogen sulfotransferase-PAPS complex: evidence for catalytic role of Ser137 in the sulfuryl transfer reaction.
Topics: Alanine; Amino Acid Substitution; Binding Sites; Catalysis; Crystallography, X-Ray; Cysteine; Estradiol; Lysine; Macromolecular Substances; Models, Chemical; Models, Molecular; Mutagenesis, Site-Directed; Phosphoadenosine Phosphosulfate; Protein Binding; Protein Conformation; Serine; Sulfates; Sulfotransferases | 2002 |
Zn(2+) binding properties of single-point mutants of the C-terminal zinc finger of the HIV-1 nucleocapsid protein: evidence of a critical role of cysteine 49 in Zn(2+) dissociation.
Topics: Alanine; Amino Acid Motifs; Amino Acid Sequence; Binding Sites; Capsid; Capsid Proteins; Cobalt; Cysteine; gag Gene Products, Human Immunodeficiency Virus; Gene Products, gag; Histidine; HIV-1; Hydrogen-Ion Concentration; Kinetics; Magnetic Resonance Spectroscopy; Models, Chemical; Molecular Sequence Data; Point Mutation; Protein Binding; Serine; Spectrophotometry; Viral Proteins; Zinc; Zinc Fingers | 2002 |
A comparison in normal individuals and sickle cell patients of reduced glutathione precursors and their transport between plasma and red cells.
Topics: Adult; Amino Acid Transport System ASC; Amino Acid Transport System L; Anemia, Sickle Cell; Biological Transport; Carbon Monoxide; Cysteine; Enzyme Inhibitors; Erythrocytes; Female; Glutamic Acid; Glutamine; Glutathione; Glycine; Humans; Male; Middle Aged; Oxygen; Protein Kinase Inhibitors; Protein Kinases; Serine; Staurosporine | 2000 |
S-thiolation of HSP27 regulates its multimeric aggregate size independently of phosphorylation.
Topics: Animals; Biotin; Biotinylation; Blotting, Western; Cysteine; Enzyme Inhibitors; Heart; Heat-Shock Proteins; HSP27 Heat-Shock Proteins; Hydrogen Peroxide; Male; Neoplasm Proteins; Oxidative Stress; Perfusion; Phosphorylation; Rats; Rats, Wistar; Serine; Sulfhydryl Compounds; Time Factors | 2002 |
Association of the hOGG1 Ser326Cys polymorphism with lung cancer risk.
Topics: Adolescent; Adult; Aged; Amino Acid Substitution; Asian People; Case-Control Studies; Cysteine; Diet; DNA Damage; DNA Repair; DNA-Formamidopyrimidine Glycosylase; Ethnicity; Genotype; Hawaii; Humans; Lung Neoplasms; Middle Aged; N-Glycosyl Hydrolases; Oxidative Stress; Polymerase Chain Reaction; Polymorphism, Genetic; Polymorphism, Restriction Fragment Length; Risk Factors; Serine; Smoking; Vegetables; White People | 2002 |
Evidence for the involvement of tetrahydrofolate in the demethylation of nicotine by Nicotiana plumbaginifolia cell-suspension cultures.
Topics: Carbon Radioisotopes; Cells, Cultured; Cysteine; Homocysteine; Magnetic Resonance Spectroscopy; Methionine; Methylation; Models, Chemical; Nicotiana; Nicotine; Plant Extracts; Serine; Tetrahydrofolates | 2002 |
Site-directed mutagenesis of cysteine to serine in the DNA binding region of Nrf2 decreases its capacity to upregulate antioxidant response element-mediated expression and antioxidant induction of NAD(P)H:quinone oxidoreductase1 gene.
Topics: Amino Acid Sequence; Animals; Antioxidants; Cysteine; DNA-Binding Proteins; Electrophoretic Mobility Shift Assay; Ethylmaleimide; Gene Expression Regulation; Humans; MafG Transcription Factor; Mice; Molecular Sequence Data; Mutagenesis, Site-Directed; NADH, NADPH Oxidoreductases; NF-E2-Related Factor 2; Repressor Proteins; Response Elements; Sequence Homology, Amino Acid; Serine; Structure-Activity Relationship; Trans-Activators; Tumor Cells, Cultured | 2002 |
The activity of leukocyte NADPH oxidase: regulation by p47PHOX cysteine and serine residues.
Topics: Alanine; Cell-Free System; Cysteine; Cytosol; Gene Expression Regulation, Enzymologic; Humans; Leukocytes; Lymphocytes; Mutation; NADPH Oxidases; Oxidation-Reduction; Phosphoproteins; Phosphorylation; Serine | 2002 |
Complete pathway for protein disulfide bond formation encoded by poxviruses.
Topics: Amino Acid Substitution; Animals; Cell Line; Chlorocebus aethiops; Cysteine; Dimerization; Disulfides; Protein Disulfide Reductase (Glutathione); Serine; Vaccinia virus; Viral Envelope Proteins | 2002 |
hOGG1 Ser(326)Cys polymorphism and modification by environmental factors of stomach cancer risk in Chinese.
Topics: Adult; Aged; Aged, 80 and over; Alcohol Drinking; Alleles; China; Cysteine; DNA-Formamidopyrimidine Glycosylase; Environment; Esophageal Neoplasms; Female; Guanine; Humans; Male; Middle Aged; N-Glycosyl Hydrolases; Odds Ratio; Oxidative Stress; Polymerase Chain Reaction; Polymorphism, Genetic; Polymorphism, Single-Stranded Conformational; Serine; Smoking; Stomach Neoplasms | 2002 |
A general asymmetric synthesis of syn- and anti-beta-substituted cysteine and serine derivatives.
Topics: Amino Acid Sequence; Aziridines; Catalysis; Chemistry, Organic; Cysteine; Esters; Magnetic Resonance Spectroscopy; Molecular Structure; Serine; Stereoisomerism; Sulfates | 2002 |
A "de novo" mutation of the LDL-receptor gene as the cause of familial hypercholesterolemia.
Topics: Child; Cysteine; Heterozygote; Humans; Hypercholesterolemia; Male; Middle Aged; Mutation; Paternity; Pedigree; Receptors, LDL; Serine | 2002 |
Relationship between protein structure and methionine oxidation in recombinant human alpha 1-antitrypsin.
Topics: alpha 1-Antitrypsin; Cysteine; Escherichia coli; Humans; Hydrogen-Ion Concentration; Kinetics; Leukocyte Elastase; Methionine; Mutagenesis, Site-Directed; Oxidation-Reduction; Peptide Mapping; Protein Conformation; Recombinant Proteins; Serine; Serine Proteinase Inhibitors | 2002 |
Activation of the plant mitochondrial alternative oxidase: insights from site-directed mutagenesis.
Topics: Adenosine Triphosphate; Amino Acid Substitution; Arabidopsis; Catalysis; Cysteine; Dimerization; Enzyme Activation; Escherichia coli; Glutamic Acid; Glyoxylates; Mitochondria; Mitochondrial Proteins; Mutagenesis, Site-Directed; Oxidoreductases; Oxygen; Plant Proteins; Protein Conformation; Pyruvic Acid; Sequence Analysis, DNA; Serine; Structure-Activity Relationship; Succinic Acid; Water | 2002 |
Apoptosis mediated through CD45 is independent of its phosphatase activity and association with leukocyte phosphatase-associated phosphoprotein.
Topics: Amino Acid Substitution; Animals; Antibodies, Monoclonal; Apoptosis; Bystander Effect; Caspases; Cysteine; Cytoplasm; Enzyme Activation; Intracellular Signaling Peptides and Proteins; Leukocyte Common Antigens; Membrane Proteins; Mice; Mice, Inbred C57BL; Mice, Knockout; Microspheres; Phosphoproteins; Precipitin Tests; Protein Structure, Tertiary; Protein Tyrosine Phosphatases; Serine; T-Lymphocytes; Thymus Gland; Transfection; Tumor Cells, Cultured | 2002 |
Organization of an efficient carbonic anhydrase: implications for the mechanism based on structure-function studies of a T199P/C206S mutant.
Topics: Amino Acid Substitution; Bicarbonates; Binding Sites; Carbon Dioxide; Carbonic Anhydrases; Catalysis; Crystallography, X-Ray; Cysteine; Humans; Mercaptoethanol; Mutagenesis, Site-Directed; Proline; Recombinant Proteins; Serine; Structure-Activity Relationship; Substrate Specificity; Thiocyanates; Threonine; Water | 2002 |
Spectroscopic properties of a mitochondrial cytochrome C with a single thioether bond to the heme prosthetic group.
Topics: Amino Acid Substitution; Binding Sites; Circular Dichroism; Cysteine; Cytochrome c Group; Cytochromes c; Electron Spin Resonance Spectroscopy; Heme; Isoenzymes; Mitochondria; Nuclear Magnetic Resonance, Biomolecular; Saccharomyces cerevisiae Proteins; Serine; Sulfides | 2002 |
Modification of heme c binding motifs in the small subunit (NrfH) of the Wolinella succinogenes cytochrome c nitrite reductase complex.
Topics: Amino Acid Motifs; Bacterial Proteins; Binding Sites; Culture Media; Cysteine; Cytochrome c Group; Cytochromes a1; Cytochromes c1; Heme; Mutagenesis, Site-Directed; Nitrate Reductases; Nitrites; Oxidation-Reduction; RNA-Binding Proteins; Serine; Transcription Factors; Wolinella | 2002 |
Biosynthesis of sulfur-containing amino acids in Streptomyces venezuelae ISP5230: roles for cystathionine beta-synthase and transsulfuration.
Topics: Amino Acid Sequence; Cloning, Molecular; Culture Media; Cystathionine beta-Synthase; Cysteine; Cysteine Synthase; Gene Deletion; Genetic Complementation Test; Methionine; Molecular Sequence Data; Sequence Analysis, DNA; Serine; Streptomyces; Sulfur | 2002 |
Chicken anemia virus VP2 is a novel dual specificity protein phosphatase.
Topics: Amino Acid Motifs; Amino Acid Sequence; Biochemical Phenomena; Biochemistry; Capsid Proteins; Cloning, Molecular; Cysteine; Genome, Viral; Glutathione Transferase; Kinetics; Molecular Sequence Data; Mutation; Phosphates; Polymerase Chain Reaction; Protein Structure, Tertiary; Protein Tyrosine Phosphatases; Recombinant Fusion Proteins; Sequence Homology, Amino Acid; Serine; Signal Transduction; Threonine; Vanadates | 2002 |
Evidence of a critical architectural function for the RAG proteins in end processing, protection, and joining in V(D)J recombination.
Topics: Alanine; Amino Acid Substitution; Animals; Cell Line; Cysteine; DNA; DNA Nucleotidyltransferases; DNA-Binding Proteins; Gene Rearrangement, B-Lymphocyte; Genes, RAG-1; Glutamic Acid; Homeodomain Proteins; Humans; Macromolecular Substances; Mice; Mutagenesis, Site-Directed; Nuclear Proteins; Nucleic Acid Conformation; Phenotype; Protein Interaction Mapping; Recombinant Fusion Proteins; Recombination, Genetic; Regulatory Sequences, Nucleic Acid; Serine; Substrate Specificity; VDJ Recombinases | 2002 |
Identification of two cysteine residues involved in the binding of UDP-GalNAc to UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 1 (GalNAc-T1).
Topics: 4-Chloromercuribenzenesulfonate; Animals; Binding Sites; Cattle; COS Cells; Cysteine; DNA Primers; Enzyme Activation; Gene Deletion; Glycosylation; Humans; Isoflurophate; Kinetics; Mutagenesis, Site-Directed; N-Acetylgalactosaminyltransferases; Polymerase Chain Reaction; Polypeptide N-acetylgalactosaminyltransferase; Rats; Recombinant Proteins; Serine; Transfection; Uridine Diphosphate; Uridine Diphosphate N-Acetylgalactosamine | 2002 |
Dynamics of wild-type HiPIPs: a Cys77Ser mutant and a partially unfolded HiPIP.
Topics: Algorithms; Amino Acid Substitution; Bacterial Proteins; Chromatium; Crystallography, X-Ray; Cysteine; Electron Spin Resonance Spectroscopy; Halorhodospira halophila; Iron-Sulfur Proteins; Mutation; Oxidation-Reduction; Photosynthetic Reaction Center Complex Proteins; Protein Folding; Serine; Temperature | 2002 |
Binding of D- and L-captopril inhibitors to metallo-beta-lactamase studied by polarizable molecular mechanics and quantum mechanics.
Topics: Algorithms; Aspartic Acid; Bacteroides fragilis; beta-Lactamase Inhibitors; beta-Lactamases; Binding Sites; Captopril; Computational Biology; Cysteine; Enzyme Inhibitors; Histidine; Models, Molecular; Molecular Structure; Protein Conformation; Serine; Static Electricity; Stereoisomerism; Zinc | 2002 |
Replacement of active-site cysteine-436 by serine converts cytochrome P450 2B4 into an NADPH oxidase with negligible monooxygenase activity.
Topics: Aryl Hydrocarbon Hydroxylases; Binding Sites; Cloning, Molecular; Cysteine; Cytochrome P450 Family 2; Hydrogen Peroxide; Multienzyme Complexes; Mutagenesis, Site-Directed; NADH, NADPH Oxidoreductases; Peroxidases; Recombinant Proteins; Sequence Deletion; Serine; Substrate Specificity | 2002 |
Beta-replacement reaction of serine-O-carbonate derivatives with thiols catalyzed by a pyridoxal model having an ionophore side-chain.
Topics: Carbonates; Catalysis; Cystathionine beta-Synthase; Cysteine; Ionophores; Lithium; Molecular Structure; Peptides; Pyridoxal; Serine; Sulfhydryl Compounds | 2002 |
An external determinant in the S5-P linker of the pacemaker (HCN) channel identified by sulfhydryl modification.
Topics: Animals; Cyclic Nucleotide-Gated Cation Channels; Cysteine; Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels; Ion Channels; Membrane Potentials; Mice; Mutagenesis; Nerve Tissue Proteins; Potassium Channels; Serine; Structure-Activity Relationship; Sulfhydryl Compounds | 2002 |
Mutations in the putative pore-forming segment favor short-lived wild-type Kir2.1 pore conformations.
Topics: Amino Acid Sequence; Amino Acid Substitution; Animals; Asparagine; Cysteine; Glycosylation; Ion Channel Gating; Isoleucine; Mice; Molecular Sequence Data; Patch-Clamp Techniques; Peptide Fragments; Phenylalanine; Point Mutation; Potassium Channels, Inwardly Rectifying; Protein Conformation; Protein Structure, Tertiary; Serine; Spodoptera; Threonine; Time Factors; Tyrosine | 2002 |
Autolytic processing at Glu586-Ser587 within the cysteine-rich domain of human adamalysin 19/disintegrin-metalloproteinase 19 is necessary for its proteolytic activity.
Topics: ADAM Proteins; Animals; Base Sequence; Cell Line; Cysteine; Disintegrins; DNA Primers; Glutamic Acid; Humans; Hydrolysis; Kinetics; Membrane Proteins; Metalloendopeptidases; Metalloproteases; Muscle Proteins; Mutagenesis; Protein Processing, Post-Translational; Serine; Substrate Specificity; Tetradecanoylphorbol Acetate | 2002 |
Improved system for protein engineering of the hydroxylase component of soluble methane monooxygenase.
Topics: Amino Acid Substitution; Cysteine; Gene Expression; Genetic Vectors; Mixed Function Oxygenases; Mutagenesis, Site-Directed; Oxygenases; Protein Engineering; Protein Subunits; Serine; Solubility; Threonine | 2002 |
Detection of intermediates in reactions catalyzed by PLP-dependent enzymes: O-acetylserine sulfhydrylase and serine-glyoxalate aminotransferase.
Topics: Bacterial Proteins; Binding Sites; Cysteine; Cysteine Synthase; Genes, Bacterial; Isoenzymes; Molecular Structure; Pyridoxal Phosphate; Schiff Bases; Serine; Spectrum Analysis; Transaminases | 2002 |
Posttranslational modification of serine to formylglycine in bacterial sulfatases. Recognition of the modification motif by the iron-sulfur protein AtsB.
Topics: Alanine; Amino Acid Motifs; Amino Acid Sequence; Arylsulfatases; beta-Galactosidase; Blotting, Western; Cysteine; Cytosol; Dose-Response Relationship, Drug; Escherichia coli; Glutathione Transferase; Glycine; Iron-Sulfur Proteins; Klebsiella pneumoniae; Models, Chemical; Molecular Sequence Data; Mutagenesis, Site-Directed; Peptides; Protein Binding; Protein Processing, Post-Translational; Protein Sorting Signals; Serine; Subcellular Fractions; Sulfatases; Two-Hybrid System Techniques | 2003 |
The risk of coronary artery disease in population of Taiwan is associated with Cys-Ser 311 polymorphism of human paraoxonase (PON)-2 gene.
Topics: Adult; Aged; Aryldialkylphosphatase; Coronary Disease; Cysteine; Esterases; Female; Genetic Predisposition to Disease; Genotype; Humans; Lipids; Male; Middle Aged; Polymorphism, Genetic; Risk; Serine; Taiwan | 2002 |
Identification of a region of the ileal-type sodium/bile acid cotransporter interacting with a competitive bile acid transport inhibitor.
Topics: Amino Acid Sequence; Animals; Bile Acids and Salts; Binding, Competitive; Biological Transport, Active; Carrier Proteins; Cell Line; CHO Cells; Cricetinae; Cysteine; Humans; Hydroxysteroid Dehydrogenases; Ileum; Kinetics; Membrane Glycoproteins; Mesylates; Mice; Molecular Sequence Data; Mutagenesis, Site-Directed; Organic Anion Transporters, Sodium-Dependent; Peptide Fragments; Rats; Recombinant Fusion Proteins; Sequence Alignment; Serine; Symporters; Taurocholic Acid; Thiazepines; Threonine; Valine | 2002 |
The mycotoxin penicillic acid inhibits Fas ligand-induced apoptosis by blocking self-processing of caspase-8 in death-inducing signaling complex.
Topics: Adaptor Proteins, Signal Transducing; Amino Acid Sequence; Animals; Apoptosis; Base Sequence; Carrier Proteins; Caspase 8; Caspase 9; Caspases; Cell Death; Cysteine; DNA Primers; Fas Ligand Protein; Fas-Associated Death Domain Protein; Glutathione; Kinetics; Lymphoma, B-Cell; Membrane Glycoproteins; Mice; Molecular Sequence Data; Mycotoxins; Penicillic Acid; Polymerase Chain Reaction; Serine; Signal Transduction; Tumor Cells, Cultured | 2003 |
Hb Colima [beta 49(CD8)Ser-->Cys]: a new hemoglobin variant.
Topics: Amino Acid Substitution; Cysteine; Female; Genetic Variation; Hemoglobins, Abnormal; Humans; Mass Screening; Mexico; Middle Aged; Serine | 2002 |
Palmitoylation of the human prostacyclin receptor. Functional implications of palmitoylation and isoprenylation.
Topics: Amino Acid Motifs; Amino Acid Sequence; Blotting, Western; Calcium; Cell Line; Cyclic AMP; Cysteine; Dose-Response Relationship, Drug; Enzyme Inhibitors; Gene Deletion; Humans; Ligands; Lipids; Models, Biological; Molecular Sequence Data; Mutagenesis, Site-Directed; Mutation; Palmitic Acid; Protein Binding; Protein Kinase C; Protein Prenylation; Protein Structure, Tertiary; Radioligand Assay; Receptors, Epoprostenol; Receptors, Prostaglandin; Serine; Signal Transduction; Time Factors; Transfection | 2003 |
Structural models of osteogenesis imperfecta-associated variants in the COL1A1 gene.
Topics: Collagen Type I; Collagen Type I, alpha 1 Chain; Computer Simulation; Cysteine; Humans; Hydrogen Bonding; Models, Molecular; Mutation; Osteogenesis Imperfecta; Protein Structure, Tertiary; Serine; Valine | 2002 |
Sulfate reduction is increased in transgenic Arabidopsis thaliana expressing 5'-adenylylsulfate reductase from Pseudomonas aeruginosa.
Topics: Arabidopsis; Cysteine; Dipeptides; Gene Expression Regulation, Enzymologic; Glutathione; Oxidation-Reduction; Oxidoreductases; Oxidoreductases Acting on Sulfur Group Donors; Plants, Genetically Modified; Pseudomonas aeruginosa; Serine; Sulfates; Sulfites; Thiosulfates | 2002 |
Structural and thermodynamic studies on a salt-bridge triad in the NADP-binding domain of glutamate dehydrogenase from Thermotoga maritima: cooperativity and electrostatic contribution to stability.
Topics: Alanine; Arginine; Binding Sites; Crystallography, X-Ray; Cysteine; Enzyme Stability; Glutamate Dehydrogenase; Glutamic Acid; Guanidine; Lysine; Mutagenesis, Site-Directed; NADP; Protein Denaturation; Protein Folding; Protein Structure, Tertiary; Recombinant Proteins; Salts; Serine; Static Electricity; Structure-Activity Relationship; Thermodynamics; Thermotoga maritima; Urea | 2002 |
Allelic variants of the serotonin(2C) receptor and neuroendocrinological responses to the serotonin(2C) receptor agonist m-chlorophenylpiperazine in healthy male volunteers.
Topics: Adrenocorticotropic Hormone; Adult; Alleles; Analysis of Variance; Area Under Curve; Cysteine; Genotype; Humans; Hydrocortisone; Male; Neurosecretory Systems; Piperazines; Polymorphism, Genetic; Prolactin; Receptor, Serotonin, 5-HT2C; Receptors, Serotonin; Serine; Serotonin Receptor Agonists | 2002 |
The unusual catalytic triad of poliovirus protease 3C.
Topics: 3C Viral Proteases; Catalysis; Catalytic Domain; Cysteine; Cysteine Endopeptidases; Deuterium; Glutamic Acid; Glutamine; Glycine; Hydrogen-Ion Concentration; Kinetics; Methionine; Models, Chemical; Mutagenesis, Site-Directed; Poliovirus; Serine; Solvents; Substrate Specificity; Temperature; Thermodynamics; Viral Proteins | 2003 |
Influence of A7-B7 disulfide bond deletion on the refolding and structure of proinsulin.
Topics: Amino Acid Substitution; Animals; Binding, Competitive; Circular Dichroism; Cysteine; Disulfides; Electrophoresis, Polyacrylamide Gel; Humans; Insulin; Oxidation-Reduction; Proinsulin; Protein Folding; Receptor, Insulin; Serine; Sulfhydryl Compounds; Swine; Trypsin | 2003 |
YfiK from Escherichia coli promotes export of O-acetylserine and cysteine.
Topics: Bacterial Outer Membrane Proteins; Culture Media; Cysteine; Escherichia coli; Escherichia coli Proteins; Gene Expression Regulation, Bacterial; Membrane Proteins; Mutation; Serine | 2003 |
Asymmetric organization of the pore region of the epithelial sodium channel.
Topics: Amiloride; Amino Acid Sequence; Animals; Binding Sites; Cations; Cysteine; DNA, Complementary; Dose-Response Relationship, Drug; Electrophysiology; Epithelial Sodium Channels; Ethyl Methanesulfonate; Indicators and Reagents; Kinetics; Lithium; Mice; Molecular Sequence Data; Mutagenesis, Site-Directed; Mutation; Oocytes; Potassium; Protein Structure, Tertiary; Sequence Homology, Amino Acid; Serine; Sodium; Sodium Channels; Time Factors; Xenopus | 2003 |
Assembly and secretion of very low density lipoproteins containing apolipoprotein B48 in transfected McA-RH7777 cells. Lack of evidence that palmitoylation of apolipoprotein B48 is required for lipoprotein secretion.
Topics: Animals; Antibodies, Monoclonal; Apolipoprotein B-48; Apolipoproteins B; Cell Line; Cysteine; Dose-Response Relationship, Drug; Endoplasmic Reticulum; Golgi Apparatus; Humans; Immunohistochemistry; Lipoproteins; Lipoproteins, VLDL; Microscopy, Fluorescence; Mutagenesis, Site-Directed; Mutation; Palmitates; Palmitic Acid; Plasmids; Protein Biosynthesis; Protein Structure, Tertiary; Protein Transport; Rats; Serine; Time Factors; Transfection; Ultracentrifugation | 2003 |
Development of an efficient "substrate-trapping" mutant of Src homology phosphotyrosine phosphatase 2 and identification of the epidermal growth factor receptor, Gab1, and three other proteins as target substrates.
Topics: 3T3 Cells; Adaptor Proteins, Signal Transducing; Alanine; Animals; Aspartic Acid; Cell Line; COS Cells; Cysteine; ErbB Receptors; Helminth Proteins; Humans; Immunoblotting; Mice; Microscopy, Fluorescence; Mutagenesis, Site-Directed; Mutation; Phosphoproteins; Phosphoric Monoester Hydrolases; Phosphorylation; Plasmids; Precipitin Tests; Protein Binding; Protein Structure, Tertiary; Serine; Signal Transduction; src Homology Domains; Transfection | 2003 |
Reaction of 1-amino-2-methylenecyclopropane-1-carboxylate with 1-aminocyclopropane-1-carboxylate deaminase: analysis and mechanistic implications.
Topics: Alanine; Amino Acid Sequence; Carbon-Carbon Lyases; Carboxylic Acids; Catalysis; Chromatography, High Pressure Liquid; Cloning, Molecular; Crotonates; Cyclopropanes; Cysteine; Dithionitrobenzoic Acid; Glycine; Kinetics; Mass Spectrometry; Molecular Sequence Data; Mutagenesis, Site-Directed; Peptide Fragments; Pseudomonas; Recombinant Proteins; Serine; Titrimetry | 2003 |
Global expression profiling of sulfur-starved Arabidopsis by DNA macroarray reveals the role of O-acetyl-l-serine as a general regulator of gene expression in response to sulfur nutrition.
Topics: Adaptation, Physiological; Anion Transport Proteins; Arabidopsis; Arabidopsis Proteins; Carrier Proteins; Cysteine; Expressed Sequence Tags; Gene Expression Profiling; Gene Expression Regulation, Plant; Genes, Plant; Glutathione; Oligonucleotide Array Sequence Analysis; Plant Leaves; Plant Roots; Serine; Statistics as Topic; Sulfates; Sulfur | 2003 |
Human gene 2 relaxin chain combination and folding.
Topics: Amino Acid Sequence; Amino Acid Substitution; Chromatography, High Pressure Liquid; Cysteine; Disulfides; Humans; Insulin; Insulin-Like Growth Factor I; Molecular Sequence Data; Oxidation-Reduction; Peptide Mapping; Protein Folding; Protein Subunits; Relaxin; Serine; Solutions; Temperature; Trypsin | 2003 |
Control of electron transport in photosystem I by the iron-sulfur cluster FX in response to intra- and intersubunit interactions.
Topics: Chlorophyll; Cyanobacteria; Cysteine; Electrochemistry; Electron Transport; Gene Deletion; Iron-Sulfur Proteins; Kinetics; Light; Light-Harvesting Protein Complexes; Models, Molecular; Mutagenesis, Site-Directed; Oxidation-Reduction; Photosynthetic Reaction Center Complex Proteins; Photosystem I Protein Complex; Serine; Urea; Vitamin K 1 | 2003 |
Two new mutations in cis on (G)gamma chain of fetal hemoglobin: Hb F-Madrid [G gamma 50(D1)Ser-->Cys] and [G gamma 75(E19)Ile-->Thr].
Topics: Base Sequence; Chromatography, High Pressure Liquid; Cysteine; Female; Fetal Blood; Fetal Hemoglobin; Globins; Hemoglobins, Abnormal; Humans; Infant, Newborn; Isoelectric Focusing; Isoleucine; Male; Mutation; Polymerase Chain Reaction; Serine; Spain; Threonine | 2003 |
The role of disulfide bonds in the assembly and function of MD-2.
Topics: Amino Acid Substitution; Antigens, Surface; Cell Line; Cysteine; Disulfides; Genetic Vectors; Humans; Kidney; Lymphocyte Antigen 96; Mutagenesis, Site-Directed; NF-kappa B; Recombinant Proteins; Serine | 2003 |
Characterization of a novel thermostable O-acetylserine sulfhydrylase from Aeropyrum pernix K1.
Topics: Amino Acid Sequence; Archaeal Proteins; Binding Sites; Cystathionine; Cysteine; Cysteine Synthase; Desulfurococcaceae; Dithiothreitol; Enzyme Activation; Enzyme Stability; Homocysteine; Hydrogen-Ion Concentration; Kinetics; Molecular Sequence Data; Sequence Homology, Amino Acid; Serine; Substrate Specificity; Sulfides; Temperature | 2003 |
Function of the loop residue Thr792 in human DNA topoisomerase II alpha.
Topics: Antigens, Neoplasm; Antineoplastic Agents; Catalysis; Cell Division; Cysteine; DNA Topoisomerases, Type II; DNA-Binding Proteins; DNA, Complementary; Dose-Response Relationship, Drug; Fungal Proteins; Genetic Complementation Test; Glutamic Acid; Glycine; Humans; Models, Molecular; Mutagenesis, Site-Directed; Mutation; Plasmids; Poly-ADP-Ribose Binding Proteins; Saccharomyces cerevisiae; Serine; Threonine; Valine | 2003 |
Actin tyrosine dephosphorylation by the Src homology 1-containing protein tyrosine phosphatase is essential for actin depolymerization after membrane IgM cross-linking.
Topics: Actins; Amino Acid Motifs; Amino Acid Sequence; Animals; Cell Line; Chickens; Cross-Linking Reagents; Cysteine; Humans; Intracellular Signaling Peptides and Proteins; Membrane Microdomains; Molecular Sequence Data; Mutagenesis, Site-Directed; Phosphorylation; Polymers; Protein Binding; Protein Transport; Protein Tyrosine Phosphatase, Non-Receptor Type 6; Protein Tyrosine Phosphatases; Receptors, Antigen, B-Cell; Serine; src Homology Domains; Substrate Specificity; Transfection; Tyrosine | 2003 |
The N-terminal cysteine pair of yeast sulfhydryl oxidase Erv1p is essential for in vivo activity and interacts with the primary redox centre.
Topics: Binding Sites; Color; Conserved Sequence; Cysteine; Dimerization; Enzyme Activation; Flavin-Adenine Dinucleotide; Genetic Complementation Test; Mitochondrial Proteins; Models, Molecular; Mutagenesis, Site-Directed; Oxidation-Reduction; Oxidoreductases; Oxidoreductases Acting on Sulfur Group Donors; Protein Structure, Tertiary; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Serine; Spectrophotometry; Structure-Activity Relationship | 2003 |
Enantioselective synthesis of alpha-methyl-D-cysteine and lanthionine building blocks via alpha-methyl-D-serine-beta-lactone.
Topics: Alanine; Cysteine; Lactones; Models, Molecular; Molecular Conformation; Molecular Structure; Serine; Sulfides | 2003 |
Mutational analysis of human papillomavirus type 16 major capsid protein L1: the cysteines affecting the intermolecular bonding and structure of L1-capsids.
Topics: Amino Acid Substitution; Animals; Capsid; Capsid Proteins; Cell Line; Centrifugation, Density Gradient; Cysteine; Electrophoresis, Polyacrylamide Gel; Insecta; Mutation; Oncogene Proteins, Viral; Papillomaviridae; Serine; Trypsin; Virus Assembly | 2003 |
Defective discoidin domain structure, subunit assembly, and endoplasmic reticulum processing of retinoschisin are primary mechanisms responsible for X-linked retinoschisis.
Topics: Amino Acid Sequence; Animals; Blotting, Western; Cell Adhesion; Cell Line; COS Cells; Cysteine; Detergents; Discoidins; Disulfides; DNA, Complementary; Electrophoresis, Polyacrylamide Gel; Endoplasmic Reticulum; Eye Proteins; Factor V; Factor VIII; Humans; Lectins; Microscopy, Fluorescence; Models, Biological; Models, Molecular; Molecular Sequence Data; Mutagenesis, Site-Directed; Mutation; Protein Folding; Protein Structure, Tertiary; Protozoan Proteins; Retinoschisis; Sequence Homology, Amino Acid; Serine; Transfection | 2003 |
Roles of individual amino acids in helix 14 of the membrane domain of proton-translocating transhydrogenase from Escherichia coli as deduced from cysteine mutagenesis.
Topics: Alkaline Phosphatase; Amino Acids; Binding Sites; Cysteine; Escherichia coli; Ethylmaleimide; Glycine; Models, Chemical; Mutagenesis, Site-Directed; Mutation; NAD; NADP; NADP Transhydrogenases; Plasmids; Protein Structure, Tertiary; Protons; Serine | 2003 |
The functional integrity of the serpin domain of C1-inhibitor depends on the unique N-terminal domain, as revealed by a pathological mutant.
Topics: Amino Acid Sequence; Base Sequence; Blotting, Western; Centrifugation, Density Gradient; Complement C1 Inactivator Proteins; Complement C1 Inhibitor Protein; Crystallography, X-Ray; Cysteine; Disulfides; DNA; Electrophoresis, Polyacrylamide Gel; Enzyme-Linked Immunosorbent Assay; Exons; Gene Deletion; Glycine; Heparin; Hot Temperature; Humans; Kinetics; Models, Molecular; Molecular Sequence Data; Mutation; Phenotype; Plasmids; Polymerase Chain Reaction; Proline; Protein Binding; Protein Conformation; Protein Structure, Tertiary; Recombinant Proteins; Serine; Serpins; Sucrose; Temperature | 2003 |
The multiple site binding of carboxypeptidase Y inhibitor (IC) to the cognate proteinase. Implications for the biological roles of the phosphatidylethanolamine-binding protein.
Topics: Amino Acid Sequence; Androgen-Binding Protein; Animals; Binding Sites; Brain; Carboxypeptidases; Carrier Proteins; Catalysis; Cathepsin A; Chromatography, Gel; Cross-Linking Reagents; Cysteine; Dose-Response Relationship, Drug; Electrophoresis, Polyacrylamide Gel; Guanidine; Kinetics; Mice; Molecular Sequence Data; Parasympathomimetics; Phosphatidylethanolamines; Phospholipid Transfer Proteins; Protein Binding; Protein Structure, Tertiary; Saccharomyces cerevisiae; Sequence Homology, Amino Acid; Serine; Time Factors; Trypsin | 2003 |
Endostatin induces autophagic cell death in EAhy926 human endothelial cells.
Topics: Acridine Orange; Adenine; Animals; Antineoplastic Agents; Apoptosis; Aprotinin; Blotting, Western; Caspases; Cell Death; Cells, Cultured; CHO Cells; Cloning, Molecular; Cricetinae; Cysteine; Cysteine Endopeptidases; Dose-Response Relationship, Drug; Endostatins; Endothelial Cells; Endothelium, Vascular; Enzyme Activation; Flow Cytometry; Glutathione Transferase; Humans; Immunohistochemistry; Leupeptins; Lysosomes; Microscopy, Electron; Microscopy, Phase-Contrast; Oxidative Stress; Reactive Oxygen Species; Recombinant Proteins; Serine; Time Factors | 2003 |
A 16-residue peptide fragment of macrophage migration inhibitory factor, MIF-(50-65), exhibits redox activity and has MIF-like biological functions.
Topics: 3T3 Cells; Amino Acid Motifs; Amino Acid Sequence; Animals; Biotinylation; Catalysis; Cell Cycle Proteins; Cell Division; Cells, Cultured; Chromatography, High Pressure Liquid; Circular Dichroism; Cyclin-Dependent Kinase Inhibitor p27; Cysteine; Disulfides; Endocytosis; Endothelium, Vascular; Glutathione; Humans; Inflammation; Kinetics; Macrophage Migration-Inhibitory Factors; Mass Spectrometry; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Molecular Sequence Data; Oxidation-Reduction; Oxygen; Peptides; Phosphorylation; Protein Binding; Protein Conformation; Serine; Signal Transduction; Sulfhydryl Compounds; Time Factors; Tumor Suppressor Proteins | 2003 |
Redox regulation of protein tyrosine phosphatase 1B involves a sulphenyl-amide intermediate.
Topics: Amides; Amino Acid Substitution; Binding Sites; Cysteine; Epidermal Growth Factor; Insulin; Models, Molecular; Oxidation-Reduction; Phosphorylation; Protein Binding; Protein Conformation; Protein Tyrosine Phosphatase, Non-Receptor Type 1; Protein Tyrosine Phosphatases; Receptor, Insulin; Serine; Sulfenic Acids | 2003 |
Essential 110Cys in active site of membrane-associated prostaglandin E synthase-2.
Topics: Amino Acid Sequence; Binding Sites; Catalytic Domain; Cysteine; Dithiothreitol; Dose-Response Relationship, Drug; Glutaredoxins; Humans; Intramolecular Oxidoreductases; Kinetics; Leucine; Molecular Sequence Data; Mutagenesis, Site-Directed; Mutation; Oxidation-Reduction; Oxidative Stress; Oxidoreductases; Prostaglandin-E Synthases; Protein Binding; Protein Structure, Tertiary; Proteins; Serine; Thioctic Acid; Thioredoxins | 2003 |
Mutational analysis of the human FATE gene in 144 infertile men.
Topics: Adult; Alanine; Amino Acid Sequence; Animals; Arginine; Cysteine; DNA Mutational Analysis; DNA Primers; DNA-Binding Proteins; Exons; Humans; Infertility, Male; Introns; Karyotyping; Male; Molecular Sequence Data; Mutation; Pedigree; Polymerase Chain Reaction; Polymorphism, Genetic; Serine; Threonine; Transcription Factors; X Chromosome | 2003 |
The C-terminal T peptide of acetylcholinesterase enhances degradation of unassembled active subunits through the ERAD pathway.
Topics: Acetylcholinesterase; Alkaline Phosphatase; Amino Acid Sequence; Amino Acid Substitution; Amino Acids, Aromatic; Animals; Chlorocebus aethiops; Conserved Sequence; COS Cells; Cysteine; Dimerization; Endoplasmic Reticulum; Humans; Lactones; Leupeptins; Molecular Sequence Data; Nippostrongylus; Peptides; Protein Subunits; Rats; Serine | 2003 |
Rim, a component of the presynaptic active zone and modulator of exocytosis, binds 14-3-3 through its N terminus.
Topics: 14-3-3 Proteins; Adaptor Proteins, Signal Transducing; Alanine; Alkaline Phosphatase; Amino Acid Motifs; Amino Acid Sequence; Animals; Calcium; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Cell Line; Chromaffin Cells; Cross-Linking Reagents; Cysteine; Dose-Response Relationship, Drug; Exocytosis; Glutathione Transferase; GTP-Binding Proteins; Humans; Models, Genetic; Molecular Sequence Data; Mutation; Nerve Tissue Proteins; Neurons; PC12 Cells; Phosphoric Monoester Hydrolases; Phosphorylation; Plasmids; Precipitin Tests; Protein Binding; Protein Structure, Tertiary; rab GTP-Binding Proteins; rab3 GTP-Binding Proteins; Rabphilin-3A; Rats; Recombinant Fusion Proteins; Sequence Homology, Amino Acid; Serine; Temperature; Transfection; Two-Hybrid System Techniques; Tyrosine 3-Monooxygenase; Vesicular Transport Proteins; Zinc Fingers | 2003 |
Efficiency of a cysteine-taurine-threonine-serine supplemented parenteral nutrition in an experimental model of acute inflammation.
Topics: Acute Disease; Animals; Cysteine; Dietary Supplements; Inflammation; Male; Parenteral Nutrition; Prospective Studies; Rats; Rats, Sprague-Dawley; Serine; Taurine; Threonine | 2003 |
Disulfide bond structure and accessibility of cysteines in the ectodomain of the cholecystokinin receptor: specific mono-reactive receptor constructs examine charge-sensitivity of loop regions.
Topics: Animals; CHO Cells; Cricetinae; Cricetulus; Cysteine; Disulfides; Mesylates; Mutation; Receptors, Cholecystokinin; Serine; Sulfhydryl Reagents | 2003 |
Replacement of the catalytic nucleophile cysteine-296 by serine in class II polyhydroxyalkanoate synthase from Pseudomonas aeruginosa-mediated synthesis of a new polyester: identification of catalytic residues.
Topics: Acyltransferases; Amino Acid Sequence; Amino Acid Substitution; Animals; Catalytic Domain; Cysteine; Epoxide Hydrolases; Mice; Models, Molecular; Molecular Sequence Data; Mutagenesis, Site-Directed; Pantetheine; Polyesters; Protein Folding; Protein Processing, Post-Translational; Protein Structure, Tertiary; Pseudomonas aeruginosa; Sequence Alignment; Serine; Substrate Specificity | 2003 |
Serine acetyltransferase of Escherichia coli: substrate specificity and feedback control by cysteine.
Topics: Acetyl Coenzyme A; Acetyltransferases; Acyl Coenzyme A; Adenosine Triphosphate; Calorimetry; Cysteine; Escherichia coli; Feedback, Physiological; Glycine; Kinetics; Serine; Serine O-Acetyltransferase; Substrate Specificity; Threonine | 2003 |
The roles of the two zinc binding sites in DnaJ.
Topics: Adenosine Triphosphatases; Adenosine Triphosphate; Bacterial Proteins; Binding Sites; Circular Dichroism; Cysteine; Drug Interactions; Escherichia coli; Escherichia coli Proteins; Gene Deletion; Gene Expression; Heat-Shock Proteins; Hot Temperature; HSP40 Heat-Shock Proteins; HSP70 Heat-Shock Proteins; Hydrolysis; Luciferases; Models, Molecular; Molecular Chaperones; Molecular Structure; Mutagenesis, Site-Directed; Plasmids; Protein Conformation; Protein Folding; Serine; Structure-Activity Relationship; Transfection; Zinc | 2003 |
Highly conserved cysteines of mouse core 2 beta1,6-N-acetylglucosaminyltransferase I form a network of disulfide bonds and include a thiol that affects enzyme activity.
Topics: Amino Acid Sequence; Animals; Bacteriophage T4; Binding Sites; Cations; Cell Adhesion; Chymotrypsin; Conserved Sequence; Cysteine; Disulfides; Dithiothreitol; Dose-Response Relationship, Drug; Glucosyltransferases; Kinetics; Mice; Models, Molecular; Molecular Sequence Data; Mutation; N-Acetylglucosaminyltransferases; Peptide-N4-(N-acetyl-beta-glucosaminyl) Asparagine Amidase; Polysaccharides; Protein Folding; Protein Isoforms; Recombinant Proteins; Reducing Agents; Sequence Homology, Amino Acid; Serine; Serine Endopeptidases; Sulfhydryl Compounds; Time Factors; Trypsin | 2003 |
Beta-catenin inhibits cell growth of a malignant mesothelioma cell line, NCI-H28, with a 3p21.3 homozygous deletion.
Topics: Annexin A5; Apoptosis; beta Catenin; Cell Division; Cell Membrane; Cell Nucleus; Chromosomes, Human, Pair 3; Cysteine; Cytoplasm; Cytoskeletal Proteins; Gene Expression Regulation, Neoplastic; Genes, Tumor Suppressor; Homozygote; Humans; In Situ Nick-End Labeling; Mesothelioma; Mutation; Neoplastic Stem Cells; Sequence Deletion; Serine; Trans-Activators; Transcription, Genetic; Tumor Cells, Cultured | 2003 |
Deamination of serine. I. Catalytic deamination of serine and cysteine by pyridoxal and metal salts.
Topics: Catalysis; Cysteine; Deamination; Metals; Pyridoxal; Salts; Serine | 1952 |
The adrenal cortex and sulfur metabolism; the influence of amino acid sulfur on the formation of liver glycogen.
Topics: Adrenal Cortex; Cysteine; Glutathione; Glycogen; Glycogenolysis; Liver; Liver Glycogen; Serine; Sulfur | 1953 |
Inhibiting effects of amino acids and related compounds upon the growth of enterotoxigenic micrococci in cream pastry.
Topics: Acetates; Amino Acids; Cysteine; Foodborne Diseases; Glycine; Glycine Agents; Micrococcus; Serine | 1953 |
The fermentation of L-threonine, L-serine, L-cysteine and acrylic acid by a gram-negative coccus.
Topics: Acids; Acrylates; Bacteria; Cysteine; Fermentation; Gram-Negative Bacteria; Serine; Threonine | 1955 |
[Cysteine biosynthesis from serine and hydrogen sulfide].
Topics: Biochemical Phenomena; Cysteine; Hydrogen Sulfide; Serine; Sulfides; Yeasts | 1957 |
The inhibition of serine metabolism in Leuconostoc mesenteroides P-60. I. Microbiological activity of D- and L-penicillamine.
Topics: Cysteine; Leuconostoc; Penicillamine; Serine | 1957 |
Antitumor activity of some amino acid analogues. I. S-carbamyl-cysteine and o-carbazylserine.
Topics: Amino Acids; Antineoplastic Agents; Cysteine; Glutamates; Humans; Serine | 1958 |
Choline biogenesis II. The effect of homocysteine on serine metabolism.
Topics: Choline; Cysteine; Homocysteine; Humans; Serine | 1961 |
[Synthesis of sulfur amino acids from cysteine, serine and phosphoserine, catalyzed by pyridoxal and a metal].
Topics: Amino Acids, Sulfur; Coenzymes; Cysteine; Metals; Phosphoserine; Pyridoxal; Serine | 1961 |
Amino acids, amino sugars and sugars present in the cell wall of some strains of Streptococcus pyogenes.
Topics: Alanine; Amino Acids; Amino Sugars; Arginine; Aspartic Acid; Cell Wall; Cysteine; Glucosamine; Glutamates; Glycine; Hexosamines; Isoleucine; Leucine; Lysine; Serine; Streptococcus pyogenes; Threonine; Valine | 1962 |
[Synthesis of natural sulfurated amino acids].
Topics: Amino Acids; Cysteine; Cystine; Homocysteine; Methionine; Serine | 1962 |
[Enzymatic synthesis of cysteine from phosphoserine and sulfur].
Topics: Cysteine; Lyases; Phosphoserine; Serine; Sulfur | 1963 |
Amino acid dependent control of DNA synthesis in bacteria and vegetative phage.
Topics: Amino Acids; Arginine; Coliphages; Cysteine; DNA; DNA, Bacterial; Escherichia coli; Histidine; Leucine; Methionine; Phenylalanine; Proline; Serine; Threonine; Tryptophan | 1962 |
GAS CHROMATOGRAPHY OF THE METHYL ESTERS OF THE AMINO ACIDS AS THE FREE BASE AND BY DISSOCIATION OF THEIR ACID SALTS.
Topics: Acetates; Amino Acids; Aspartic Acid; Chlorides; Chromatography; Chromatography, Gas; Cysteine; Cystine; Esters; Hydroxyproline; Ion Exchange Resins; Leucine; Lysine; Phenylalanine; Proline; Research; Salts; Serine | 1963 |
STUDIES ON COLLETOTRICHUM CAPSICI III. THE EFFECT OF INITIAL PH ON THE GROWTH AND AMINO ACID COMPOSITION.
Topics: Alanine; Amino Acids; Aminobutyrates; Arginine; Aspartic Acid; Chromatography; Colletotrichum; Cysteine; Fungi; Glutamates; Glutamine; Glycine; Histidine; Hydrogen-Ion Concentration; Isoleucine; Leucine; Phenylalanine; Research; Serine; Tyrosine | 1963 |
SUCCINIC ESTER AND AMIDE OF HOMOSERINE: SOME SPONTANEOUS AND ENZYMATIC REACTIONS.
Topics: Amides; Amino Acids; Cysteine; Escherichia coli; Homoserine; Methionine; Pyridoxal Phosphate; Research; Salmonella; Serine; Succinates | 1964 |
[NON-ENZYMIC SYNTHESIS OF CYSTEIC ACID FROM SOME BETA-SUBSTITUTED AMINO ACIDS, PYRUVATE, SULPHITE, AND COPPER IONS].
Topics: Amino Acid Substitution; Amino Acids; Catalysis; Chelating Agents; Chemical Phenomena; Chemistry; Copper; Cysteic Acid; Cysteine; Pyridoxal Phosphate; Pyruvates; Pyruvic Acid; Research; Serine; Sulfites; Sulfur | 1963 |
[SPECIFICITY OF ACTIVATION ENZYMES WITH RESPECT TO RIBONUCLEIC ACIDS ESTERIFIED BY AMINO ACIDS].
Topics: Alanine; Amino Acids; Animals; Carbon Isotopes; Chromatography; Cysteine; Escherichia coli; Ligases; Methionine; Nucleoproteins; Poultry; Proteins; Research; RNA; RNA, Bacterial; Serine; Sulfur Isotopes; Tyrosine | 1963 |
ASPECTS OF CHEMORECEPTION IN CRUSTACEA.
Topics: Aminobutyrates; Animals; Aspartic Acid; Crustacea; Cysteine; Electrophysiology; Glutamates; Glutathione; Glycine; Glycogen; Histamine; Indoles; Leucine; Methionine; Muscles; Pharmacology; Research; Sensory Receptor Cells; Serine; Tyrosine; Urea | 1963 |
[EFFECTS OF HYDROXYLAMINE ON ESCHERICHIA COLI DEVELOPMENT].
Topics: Arginine; Cysteine; Escherichia coli; Hydroxylamine; Hydroxylamines; Methionine; Pharmacology; Proteins; Research; Serine | 1964 |
POLYNUCLEOTIDE ANALOGUES. II. STIMULATION OF AMINO ACID INCORPORATION BY POLYNUCLEOTIDE ANALOGUES.
Topics: Amino Acids; Carbon Isotopes; Chromatography; Cysteine; Escherichia coli; Glycine; Isoleucine; Leucine; Lysine; Pharmacology; Phenylalanine; Polynucleotides; Proline; Proteins; Research; Serine; Threonine; Tryptophan; Tyrosine; Uracil Nucleotides; Valine | 1964 |
ELECTROENCEPHALOGRAMS OF SHARKS.
Topics: Animals; Brain; Cerebellum; Crustacea; Cysteine; Diencephalon; Electroencephalography; Electrophysiology; Glutamates; Glycine; Light; Limbic System; Medulla Oblongata; Mesencephalon; Research; Serine; Sharks; Telencephalon; Tissue Extracts | 1964 |
REPRESSION BY METHIONINE OF CYSTATHIONASE FORMATION IN ESCHERICHIA COLI.
Topics: Amino Acids; Chloramphenicol; Cystathionine gamma-Lyase; Cysteine; Enzymes; Escherichia coli; Homocysteine; Methionine; Proteins; Pyruvates; Research; Salmonella; Serine | 1964 |
CATALYTIC PROPERTIES OF TRYPTOPHANASE, A MULTIFUNCTIONAL PYRIDOXAL PHOSPHATE ENZYME.
Topics: Aminohydrolases; Ammonia; Animals; Catalysis; Cattle; Cysteine; Electrophoresis; Escherichia coli; Indoles; Leuconostoc; Manometry; Multifunctional Enzymes; Mutation; Potassium; Pyridoxal Phosphate; Pyruvates; Research; Serine; Serum Albumin; Serum Albumin, Bovine; Tryptophan | 1964 |
A SIMPLE PREPARATION METHOD FOR DIPHOSPHOMIDAZOLE.
Topics: Alanine; Amides; Calcium Phosphates; Chlorides; Chromatography; Cysteine; Cystine; Glycine; Histidine; Imidazoles; Ion Exchange Resins; Methionine; Phosphates; Phosphorus; Research; Serine; Tryptophan; Tyrosine | 1964 |
NUTRITIONAL FACTORS RELATING TO GROWTH AND OXYTETRACYCLINE FORMATION BY STREPTOMYCES RIMOSUS.
Topics: Alanine; Amino Acids; Arginine; Aspartic Acid; Culture Media; Cysteine; Cystine; Glutamine; Glycine; Histidine; Isoleucine; Lysine; Metabolism; Methionine; Oxytetracycline; Research; Serine; Streptomyces; Streptomyces rimosus | 1964 |
INOTROPIC ACTIVITY OF A SERIES OF AMINO ACIDS.
Topics: Adrenal Glands; Alanine; Amino Acids; Blood Pressure; Cysteine; Dogs; Glycine; Heart; Leucine; Methionine; Pharmacology; Research; Sensory Receptor Cells; Serine; Threonine | 1964 |
FUNCTION-SPECIFIC CHANGES IN THE METABOLISM OF AGOUTI PIGMENT CELLS.
Topics: Animals; Chromatophores; Cysteine; Dasyproctidae; Dihydroxyphenylalanine; Glutathione; Hair; Leucine; Melanins; Metabolism; Mice; Research; Serine; Sulfhydryl Compounds; Tyrosine | 1964 |
CYSTATHIONINE CLEAVAGE ENZYMES OF NEUROSPORA.
Topics: Amino Acid Oxidoreductases; Amino Acids; Butyrates; Cystathionine; Cysteine; Homocysteine; Iodoacetates; L-Lactate Dehydrogenase; Maleates; Neurospora; Pyridoxal Phosphate; Pyruvates; Research; Serine; Sulfhydryl Compounds | 1964 |
PURIFICATION AND PROPERTIES OF THE CYSTATHIONINE GAMMA-CLEAVAGE ENZYME OF NEUROSPORA.
Topics: Amino Acid Oxidoreductases; Amino Acids; Butyrates; Cystathionine; Cysteine; Cystine; Enzyme Inhibitors; Ethers; Gamma Rays; Neurospora; Pyridoxal Phosphate; Research; Serine; Sulfides | 1964 |
CLUSTERING OF FUNCTIONALLY RELATED GENES IN SALMONELLA TYPHIMURIUM.
Topics: Arginine; Cysteine; Escherichia coli; Glycine; Guanine; Histidine; Isoleucine; Leucine; Metabolism; Methionine; Molecular Biology; Mutation; Pantothenic Acid; Proline; Purines; Pyrimidines; Research; Salmonella typhimurium; Serine; Threonine; Tryptophan | 1964 |
THE DEVELOPMENTAL SIGNIFICANCE OF ALANINE DEHYDROGENASE IN BACILLUS SUBTILIS.
Topics: Alanine; Alanine Dehydrogenase; Alanine Transaminase; Amino Acid Oxidoreductases; Amino Acids; Aminobutyrates; Ammonia; Aspartate Aminotransferases; Bacillus subtilis; Cysteine; Isoleucine; Leucine; Lyases; Methionine; Mutation; Research; Serine; Spectrophotometry; Spores; Spores, Bacterial; Valine | 1964 |
SOME IN VITRO STUDIES OF POLONIUM-210 BINDING BY BLOOD CONSTITUENTS.
Topics: Amino Acids; Aspartic Acid; Bicarbonates; Blood; Citrates; Cysteine; Glutamates; Glycine; Histidine; Hydrogen-Ion Concentration; Imidazoles; In Vitro Techniques; Malates; Metabolism; Phosphates; Polonium; Research; Serine; Tryptophan | 1964 |
[ENZYMATIC BETA SUBSTITUTION OF PHOSPHOSERINE AND CYSTEINE BY SULFITE. SOME REMARKS ON THE MECHANISM OF BETA SUBSTITUTION IN THE PRESENCE OF PYRIDOXAL PHOSPHATE ENZYMES].
Topics: Cysteine; Extraembryonic Membranes; Hydro-Lyases; Lyases; Phosphates; Phosphoserine; Pyridoxal Phosphate; Serine; Sulfites; Sulfonic Acids; Sulfur Isotopes; Vitelline Membrane | 1964 |
AMINO ACIDS AS PROTECTIVE COMPOUNDS IN ULTRAVIOLET-IRRADIATED HANSENULA WINGEI.
Topics: Alanine; Amino Acids; Arginine; Cysteine; Cystine; Ethionine; Glutamates; Histidine; Isoleucine; Leucine; Lysine; Methionine; Pharmacology; Phenylalanine; Pichia; Proline; Radiation-Protective Agents; Research; Serine; Threonine; Tryptophan; Tyrosine; Ultraviolet Rays; Valine; Yeasts | 1964 |
SELENOAMINO ACIDS AS RADIATION PROTECTORS IN VITRO.
Topics: Alanine; Alcohol Oxidoreductases; Amino Acids; Arginine; Cysteine; Cystine; Histidine; In Vitro Techniques; Leucine; Methionine; Phenylalanine; Radiation-Protective Agents; Research; Ribonucleases; Selenium; Serine | 1964 |
THE INFLUENCE OF ETHIONINE, METHIONINE, CHOLINE, AND RELATED COMPOUNDS ON LIVER GLYCOGEN DEPOSITION IN ADRENALECTOMIZED RATS: RELATION TO THE MODE OF ACTION OF GLUCOCORTICOIDS.
Topics: Adrenalectomy; Choline; Cysteine; Ethionine; Glucocorticoids; Glucose; Homocysteine; Hydrocortisone; Liver; Liver Glycogen; Methionine; Pharmacology; Research; Serine; Tyrosine | 1964 |
THE MAJOR ALKALINE PROTEINASE OF ASPERGILLUS ORYZAE, ASPERGILLOPEPTIDASE B. II. PARTIAL SPECIFIC VOLUME, MOLECULAR WEIGHT, AND AMINO ACID COMPOSITION.
Topics: Alanine; Amides; Amino Acids; Aspergillus; Aspergillus oryzae; Bacterial Proteins; Buffers; Chemical Phenomena; Chemistry, Physical; Cysteine; Cystine; Densitometry; Endopeptidases; Glycine; Molecular Weight; Nitrogen; Peptide Hydrolases; Research; Serine; Serine Endopeptidases; Tryptophan | 1964 |
ENZYMATIC PROPERTIES OF ALANINE DEHYDROGENASE OF BACILLUS SUBTILIS.
Topics: Alanine; Alanine Dehydrogenase; Amino Acid Oxidoreductases; Amino Acids; Aminobutyrates; Bacillus subtilis; Benzoates; Caproates; Chemical Phenomena; Chemistry; Chloromercuribenzoates; Cysteine; Isoleucine; Ketoglutaric Acids; Metals; NAD; Oxalates; Pyruvates; Research; Serine; Valine | 1965 |
TRANSFORMATION OF L-SERINE PEPTIDES TO L-CYSTEINE PEPTIDES.
Topics: Chemical Phenomena; Chemistry; Cysteine; Peptides; Research; Serine | 1965 |
TRIFLUROACETYLATED AMINO ACID ESTERS: THE STABILITY OF THE DERIVATIVES OF CYSTEINE, HYDROXYPROLINE, SERINE, THREONINE AND TYROSINE.
Topics: Acetates; Amino Acids; Chemical Phenomena; Chemistry; Cysteine; Esters; Hydroxyproline; Research; Serine; Threonine; Tyrosine | 1965 |
SULFONYL FLUORIDES AS INHIBITORS OF ESTERASES. 3. IDENTIFICATION OF SERINE AS THE SITE OF SULFONYLATION IN PHENYLMETHANESULFONYL ALPHA-CHYMOTRYPSIN.
Topics: Binding Sites; Chemical Phenomena; Chemistry; Chymotrypsin; Cysteine; Enzyme Inhibitors; Esterases; Hydrogen-Ion Concentration; Research; Serine; Sulfinic Acids; Sulfonic Acids | 1965 |
THE PERIODATE OXIDATION OF AMINO ACIDS WITH REFERENCE TO STUDIES ON GLYCOPROTEINS.
Topics: Amino Acids; Cysteine; Cystine; Glycoproteins; Histidine; Hydrogen-Ion Concentration; Hydroxyproline; Indoles; Isoleucine; Leucine; Methionine; Oxidation-Reduction; Periodic Acid; Phenylalanine; Proline; Pyrroles; Research; Serine; Threonine; Tryptophan; Tyrosine | 1965 |
[CHROMATOGRAPHY OF SERYL-RNA AND CYSTEINYL-RNA ON COLUMNS OF METHYLATED ALBUMIN ON KIESELGUHR].
Topics: Chromatography; Countercurrent Distribution; Cysteine; Diatomaceous Earth; Escherichia coli; Research; RNA; RNA, Bacterial; Serine; Serum Albumin; Yeasts | 1965 |
Receptor activator of NF-kappa B ligand stimulates recruitment of SHP-1 to the complex containing TNFR-associated factor 6 that regulates osteoclastogenesis.
Topics: Animals; Carrier Proteins; Cell Differentiation; Cell Line; Cysteine; Genetic Vectors; Glycoproteins; Intracellular Signaling Peptides and Proteins; Ligands; Macrophages; Membrane Glycoproteins; Mice; Mice, Inbred C57BL; Mice, Mutant Strains; NF-kappa B; Osteoclasts; Osteoprotegerin; Phosphatidylinositol 3-Kinases; Phosphorylation; Protein Phosphatase 1; Protein Serine-Threonine Kinases; Protein Subunits; Protein Transport; Protein Tyrosine Phosphatase, Non-Receptor Type 6; Protein Tyrosine Phosphatases; Proteins; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; RANK Ligand; Receptor Activator of Nuclear Factor-kappa B; Receptors, Cytoplasmic and Nuclear; Receptors, Tumor Necrosis Factor; Retroviridae; Serine; src Homology Domains; TNF Receptor-Associated Factor 6; Transduction, Genetic; Tyrosine; Up-Regulation | 2003 |
Oxidative inactivation of purified plasma membrane Ca2+-ATPase by hydrogen peroxide and protection by calmodulin.
Topics: Animals; Calcium-Transporting ATPases; Calmodulin; Cation Transport Proteins; Cattle; Cysteine; Dithiothreitol; Enzyme Activation; Erythrocyte Membrane; Histidine; Humans; Hydrogen Peroxide; Leucine; Oxidation-Reduction; Plasma Membrane Calcium-Transporting ATPases; Protein Conformation; Serine; Spectrometry, Fluorescence; Tyrosine; Valine | 2003 |
Motif CXCC in nitrile hydratase activator is critical for NHase biogenesis in vivo.
Topics: Amino Acid Motifs; Amino Acid Sequence; Amino Acid Substitution; Binding Sites; Consensus Sequence; Cysteine; DNA Primers; Enzyme Activation; Escherichia coli; Gene Expression; Hydro-Lyases; Molecular Sequence Data; Mutagenesis, Site-Directed; Oxidation-Reduction; Protein Binding; Protein Subunits; Recombinant Proteins; Rhodococcus; Serine | 2003 |
Nonnative interactions between cysteines direct productive assembly of P22 tailspike protein.
Topics: Amino Acid Substitution; Binding Sites; Cysteine; Dimerization; Glycoside Hydrolases; Macromolecular Substances; Mutation; Protein Binding; Protein Conformation; Protein Folding; Recombinant Proteins; Serine; Structure-Activity Relationship; Viral Tail Proteins | 2003 |
Serine substitution for cysteine residues in levansucrase selectively abolishes levan forming activity.
Topics: Amino Acid Sequence; Amino Acid Substitution; Cloning, Molecular; Cysteine; Escherichia coli; Fructans; Hexosyltransferases; Molecular Sequence Data; Mutagenesis, Site-Directed; Protein Engineering; Sequence Homology, Amino Acid; Serine; Sucrose; Zymomonas | 2003 |
Roles of TRP14, a thioredoxin-related protein in tumor necrosis factor-alpha signaling pathways.
Topics: Apoptosis; Binding Sites; Carrier Proteins; Cysteine; Cytoplasm; Disulfides; Drosophila Proteins; Dyneins; Enzyme Activation; Flow Cytometry; HeLa Cells; Humans; Immunoblotting; JNK Mitogen-Activated Protein Kinases; MAP Kinase Kinase Kinase 5; MAP Kinase Kinase Kinases; Membrane Proteins; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Protein Binding; RNA Interference; RNA, Messenger; RNA, Small Interfering; Serine; Signal Transduction; Thioredoxins; Time Factors; Transcription, Genetic; Transfection; Trypsin; Tumor Necrosis Factor-alpha | 2004 |
The fragmentations of [M-H]- anions derived from underivatised peptides. The side-chain loss of H2S from Cys. A joint experimental and theoretical study.
Topics: Cysteine; Gas Chromatography-Mass Spectrometry; Hydrogen Sulfide; Peptides; Serine; Spectrometry, Mass, Electrospray Ionization | 2003 |
Role of His-16 in turnover of T4 pyrimidine dimer glycosylase.
Topics: Alanine; Aspartic Acid; Cell Survival; Cysteine; Dimerization; DNA; DNA Glycosylases; DNA Repair; Escherichia coli; Glutamic Acid; Histidine; Kinetics; Lysine; Models, Biological; Mutagenesis, Site-Directed; Mutation; Oligonucleotides; Phenotype; Plasmids; Serine; Time Factors; Ultraviolet Rays | 2004 |
Distribution and pharmacology of alanine-serine-cysteine transporter 1 (asc-1) in rodent brain.
Topics: Alanine; Amino Acid Transport System A; Amino Acid Transport System ASC; Amino Acid Transport System L; Amino Acid Transport System y+; Animals; beta-Alanine; Blotting, Western; Brain; Brain Chemistry; Cell Line; Cysteine; Dose-Response Relationship, Drug; Embryo, Mammalian; Fusion Regulatory Protein-1; Glycine; Humans; Immunohistochemistry; Kidney; Male; Mice; Rats; Rats, Wistar; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Serine; Sodium; Synaptosomes; Transfection | 2003 |
The squamous cell carcinoma antigen 2 inhibits the cysteine proteinase activity of a major mite allergen, Der p 1.
Topics: Allergens; Amino Acid Sequence; Antigens, Dermatophagoides; Antigens, Neoplasm; Arthropod Proteins; Catalysis; Chromatography, Gel; Cysteine; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; DNA, Complementary; Dose-Response Relationship, Drug; Humans; Jurkat Cells; Kinetics; Molecular Sequence Data; Peptides; Plasmids; Protein Binding; Protein Conformation; Protein Structure, Tertiary; Pyroglyphidae; Receptors, Interleukin-2; Recombinant Proteins; Serine; Serpins; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Temperature; Time Factors | 2004 |
Solution structure and stability of the full-length excisionase from bacteriophage HK022.
Topics: Amino Acid Motifs; Bacteriophage HK022; Calorimetry, Differential Scanning; Cysteine; DNA; DNA Nucleotidyltransferases; Hydrogen-Ion Concentration; Isoaspartic Acid; Magnetic Resonance Spectroscopy; Models, Chemical; Models, Molecular; Mutation; Plasmids; Proline; Protein Conformation; Protein Structure, Secondary; Protein Structure, Tertiary; Serine; Temperature; Thermodynamics; Viral Proteins; Water | 2003 |
Single-molecule fluorescence resonance energy transfer reveals a dynamic equilibrium between closed and open conformations of syntaxin 1.
Topics: Amino Acid Substitution; Antigens, Surface; Cysteine; Fluorescence Resonance Energy Transfer; Kinetics; Models, Molecular; Mutagenesis, Site-Directed; Nerve Tissue Proteins; Protein Conformation; Recombinant Proteins; Serine; Syntaxin 1 | 2003 |
Modification of human 5-HT(2C) receptor function by Cys23Ser, an abundant, naturally occurring amino-acid substitution.
Topics: Amino Acid Substitution; Animals; Binding, Competitive; Blood Proteins; Calcium; COS Cells; Cysteine; Gene Expression; Humans; Iodine Radioisotopes; Piperazines; Polymorphism, Genetic; Radioligand Assay; Receptor, Serotonin, 5-HT2C; Serine; Serotonin Receptor Agonists | 2004 |
Possible association between Cys311Ser polymorphism of paraoxonase 2 gene and late-onset Alzheimer's disease in Chinese.
Topics: Aged; Aged, 80 and over; Alleles; Alzheimer Disease; Apolipoproteins E; Aryldialkylphosphatase; Asian People; Chi-Square Distribution; Cysteine; Female; Gene Frequency; Genetic Predisposition to Disease; Genotype; Humans; Male; Polymerase Chain Reaction; Polymorphism, Genetic; Serine | 2004 |
Lacticin 481: in vitro reconstitution of lantibiotic synthetase activity.
Topics: Amino Acid Sequence; Bacterial Proteins; Bacteriocins; Cloning, Molecular; Cysteine; Enzymes; Escherichia coli; Lactococcus lactis; Molecular Sequence Data; Mutation; Protein Precursors; Protein Processing, Post-Translational; Serine; Spectrometry, Mass, Electrospray Ionization; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Substrate Specificity; Threonine | 2004 |
Characterization and metabolic function of a peroxisomal sarcosine and pipecolate oxidase from Arabidopsis.
Topics: Amino Acid Sequence; Arabidopsis; Cucurbita; Cysteine; DNA, Complementary; Escherichia coli; Formaldehyde; Gas Chromatography-Mass Spectrometry; Glycine; Hydrogen Peroxide; Mass Spectrometry; Microbodies; Models, Chemical; Molecular Sequence Data; Nitrogen; Oxidoreductases Acting on CH-NH Group Donors; Oxygen; Peroxisomes; Protein Structure, Tertiary; Recombinant Proteins; Reverse Transcriptase Polymerase Chain Reaction; RNA Interference; RNA, Messenger; Sarcosine; Sequence Homology, Amino Acid; Serine; Spectrometry, Mass, Electrospray Ionization; Tetrahydrofolates | 2004 |
The distinct heme coordination environments and heme-binding stabilities of His39Ser and His39Cys mutants of cytochrome b5.
Topics: Animals; Cattle; Cysteine; Cytochromes b5; Electrophoresis, Polyacrylamide Gel; Heme; Histidine; Mass Spectrometry; Mutation; Protein Denaturation; Serine; Temperature | 2003 |
Rescue of protein splicing activity from a Magnetospirillum magnetotacticum intein-like element.
Topics: Alanine; Alternative Splicing; Catalysis; Cysteine; Magnetospirillum; Models, Genetic; Mutation; Phenylalanine; Polymorphism, Genetic; Protein Splicing; Protein Structure, Tertiary; RNA Splicing; Serine; Tyrosine | 2004 |
3C-like proteinase from SARS coronavirus catalyzes substrate hydrolysis by a general base mechanism.
Topics: Alanine; Amino Acid Substitution; Catalysis; Colorimetry; Coronavirus 3C Proteases; Cysteine; Cysteine Endopeptidases; Deuterium Exchange Measurement; Endopeptidases; Histidine; Hydrogen-Ion Concentration; Hydrolysis; Kinetics; Mutagenesis, Site-Directed; Serine; Severe acute respiratory syndrome-related coronavirus; Solvents; Substrate Specificity; Temperature; Thermodynamics; Viral Proteins | 2004 |
Effects of betaine in a murine model of mild cystathionine-beta-synthase deficiency.
Topics: Animal Feed; Animals; Betaine; Betaine-Homocysteine S-Methyltransferase; Choline; Cystathionine beta-Synthase; Cysteine; Female; Heterozygote; Homocysteine; Hyperhomocysteinemia; Lipotropic Agents; Liver; Male; Methionine; Methyltransferases; Mice; Mice, Inbred C57BL; Regression Analysis; Serine | 2004 |
Evidence for a proton transfer network and a required persulfide-bond-forming cysteine residue in Ni-containing carbon monoxide dehydrogenases.
Topics: Alanine; Aldehyde Oxidoreductases; Asparagine; Bacterial Proteins; Biological Transport; Catalysis; Clostridium; Cysteine; Electron Spin Resonance Spectroscopy; Histidine; Lysine; Multienzyme Complexes; Mutagenesis, Site-Directed; Nickel; Protons; Serine; Sulfides | 2004 |
Structure-activity relationships for the beta-hairpin cationic antimicrobial peptide polyphemusin I.
Topics: Amino Acid Substitution; Antimicrobial Cationic Peptides; Cell Membrane; Circular Dichroism; Cysteine; Magnetic Resonance Spectroscopy; Peptides; Protein Transport; Serine; Structure-Activity Relationship; Time Factors | 2004 |
Targeting of endothelial nitric-oxide synthase to the cytoplasmic face of the Golgi complex or plasma membrane regulates Akt- versus calcium-dependent mechanisms for nitric oxide release.
Topics: Animals; Blotting, Western; Calcium; Calmodulin; Cell Membrane; COS Cells; Cysteine; Cytoplasm; Endothelium, Vascular; Golgi Apparatus; Humans; Microscopy, Fluorescence; Myristic Acids; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Palmitic Acids; Phosphorylation; Protein Serine-Threonine Kinases; Protein Structure, Tertiary; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Serine; Transfection; Umbilical Veins | 2004 |
Identification of two novel clusters of ultrahigh-sulfur keratin-associated protein genes on human chromosome 11.
Topics: Amino Acid Sequence; Base Sequence; Chromosomes, Human, Pair 11; Cysteine; Gene Expression; Genome, Human; Glycine; Hair Follicle; Humans; Keratins; Molecular Sequence Data; Multigene Family; Open Reading Frames; Promoter Regions, Genetic; Sequence Alignment; Serine; Skin; Tissue Distribution | 2004 |
The importance of a critical protonation state and the fate of the catalytic steps in class A beta-lactamases and penicillin-binding proteins.
Topics: Amino Acid Motifs; Bacterial Proteins; beta-Lactamases; Binding Sites; Carrier Proteins; Catalysis; Cloning, Molecular; Cysteine; Escherichia coli; Genetic Vectors; Glutamic Acid; Hexosyltransferases; Hydrogen-Ion Concentration; Ions; Kinetics; Lysine; Magnetic Resonance Spectroscopy; Models, Chemical; Models, Molecular; Muramoylpentapeptide Carboxypeptidase; Mutation; Penicillin-Binding Proteins; Peptidyl Transferases; Protein Binding; Protons; Serine; Thermodynamics | 2004 |
Zinc-dependent dimerization of the folding catalyst, protein disulfide isomerase.
Topics: Amino Acid Substitution; Animals; Binding Sites; Catalysis; Cysteine; Dimerization; Endoplasmic Reticulum; Mutagenesis, Site-Directed; Point Mutation; Protein Binding; Protein Disulfide-Isomerases; Protein Folding; Protein Structure, Tertiary; Serine; Structural Homology, Protein; Thioredoxins; Zinc | 2004 |
Determinants of function and substrate specificity in human UDP-galactose 4'-epimerase.
Topics: Alleles; Binding Sites; Catalysis; Cysteine; Escherichia coli; Galactose; Humans; Models, Biological; Models, Molecular; Mutation; Pichia; Plasmids; Saccharomyces cerevisiae; Serine; Substrate Specificity; Tyrosine; UDPglucose 4-Epimerase; Uridine Diphosphate N-Acetylgalactosamine; Uridine Diphosphate N-Acetylglucosamine | 2004 |
Characterization of MOCS1A, an oxygen-sensitive iron-sulfur protein involved in human molybdenum cofactor biosynthesis.
Topics: Amino Acid Motifs; Amino Acid Sequence; Carbon-Carbon Lyases; Catalysis; Circular Dichroism; Coenzymes; Conserved Sequence; Cysteine; Electron Spin Resonance Spectroscopy; Escherichia coli; Humans; Iron; Iron-Sulfur Proteins; Magnetics; Metalloproteins; Molecular Sequence Data; Molybdenum Cofactors; Mutation; Nuclear Proteins; Oxygen; Protein Structure, Tertiary; Pteridines; Sequence Homology, Amino Acid; Serine; Spectrophotometry; Spectroscopy, Mossbauer; Spectrum Analysis, Raman; Ultraviolet Rays | 2004 |
Role of cysteine residues in the NCKX2 Na+/Ca(2+)-K+ Exchanger: generation of a functional cysteine-free exchanger.
Topics: Alanine; Amino Acid Sequence; Cell Line; Cysteine; Humans; Molecular Sequence Data; Mutagenesis; Precipitin Tests; Retinal Cone Photoreceptor Cells; Serine; Sodium-Calcium Exchanger; Spectrometry, Fluorescence | 2004 |
Active rhodanese lacking nonessential sulfhydryl groups has increased hydrophobic exposure not observed in wild-type enzyme.
Topics: Amino Acid Substitution; Anilino Naphthalenesulfonates; Animals; Cattle; Cysteine; Enzyme Stability; Fluorescent Dyes; Hydrophobic and Hydrophilic Interactions; Light; Photochemistry; Protein Binding; Protein Conformation; Serine; Thiosulfate Sulfurtransferase | 2004 |
Sulphur and nitrogen nutrition influence the response of chickpea seeds to an added, transgenic sink for organic sulphur.
Topics: Cicer; Cysteine; Methionine; Nitrogen; Plant Proteins; Plants, Genetically Modified; Seeds; Serine; Signal Transduction; Sulfur | 2004 |
Evidence for disulfide involvement in the regulation of intramolecular autolytic processing by human adamalysin19/ADAM19.
Topics: ADAM Proteins; Animals; Catalytic Domain; Chlorocebus aethiops; COS Cells; Cysteine; Dipeptides; Disintegrins; Disulfides; Dithiothreitol; Dogs; Humans; Hydrogen-Ion Concentration; Metalloendopeptidases; Mutagenesis, Site-Directed; Protein Processing, Post-Translational; Protein Structure, Tertiary; Serine | 2004 |
Three-dimensional solution structure of the cytoplasmic B domain of the mannitol transporter IImannitol of the Escherichia coli phosphotransferase system.
Topics: Amino Acid Motifs; Binding Sites; Cysteine; Cytoplasm; Escherichia coli; Escherichia coli Proteins; Hydrogen-Ion Concentration; Magnetic Resonance Spectroscopy; Models, Molecular; Monosaccharide Transport Proteins; Peptides; Phosphoenolpyruvate Sugar Phosphotransferase System; Phosphorylation; Phosphotransferases; Protein Binding; Protein Conformation; Protein Structure, Tertiary; Serine | 2004 |
The cytoplasmic membrane-proximal domain of the HtrII transducer interacts with the E-F loop of photoactivated Natronomonas pharaonis sensory rhodopsin II.
Topics: Archaeal Proteins; Bacteria; Carotenoids; Cell Membrane; Cross-Linking Reagents; Cysteine; Cytoplasm; Dimerization; Disulfides; Dose-Response Relationship, Drug; Energy Transfer; Fluorescence Resonance Energy Transfer; Fluorescent Dyes; Light; Models, Chemical; Models, Molecular; Mutagenesis, Site-Directed; Mutation; Plasmids; Protein Binding; Protein Conformation; Protein Structure, Tertiary; Serine; Signal Transduction; Solvents; Time Factors | 2004 |
The fourth transmembrane domain of the Helicobacter pylori Na+/H+ antiporter NhaA faces a water-filled channel required for ion transport.
Topics: Alanine; Amino Acid Sequence; Antiporters; Aspartic Acid; Binding Sites; Cell Membrane; Cysteine; Cytoplasm; DNA; Escherichia coli; Escherichia coli Proteins; Ethylmaleimide; Helicobacter pylori; Ion Transport; Ions; Kinetics; Leucine; Lithium; Molecular Sequence Data; Mutagenesis, Site-Directed; Mutation; Phenylalanine; Plasmids; Protein Binding; Protein Conformation; Protein Structure, Secondary; Protein Structure, Tertiary; Protons; Serine; Sodium-Hydrogen Exchangers; Threonine; Valine; Water | 2004 |
Crystal structure of a bacterial type III polyketide synthase and enzymatic control of reactive polyketide intermediates.
Topics: Acyltransferases; Asparagine; Aspartic Acid; Binding Sites; Catalysis; Catalytic Domain; Chromatography, High Pressure Liquid; Chromatography, Thin Layer; Codon; Crystallography, X-Ray; Cysteine; Escherichia coli; Evolution, Molecular; Hydrogen-Ion Concentration; Magnetic Resonance Spectroscopy; Models, Chemical; Models, Molecular; Mutagenesis, Site-Directed; Mutation; Naphthols; Naphthoquinones; Oxalic Acid; Polyketide Synthases; Protein Conformation; Protein Structure, Tertiary; Serine; Streptomyces; Streptomyces coelicolor | 2004 |
Increased glutathione biosynthesis plays a role in nickel tolerance in thlaspi nickel hyperaccumulators.
Topics: Acetyltransferases; Arabidopsis; Cysteine; Enzyme Activation; Glutathione; Glutathione Reductase; Lipid Peroxidation; Molecular Sequence Data; Nickel; Oxidative Stress; Plant Shoots; Plants, Genetically Modified; Reactive Oxygen Species; Serine; Serine O-Acetyltransferase; Sulfur; Thiobarbituric Acid Reactive Substances; Thlaspi | 2004 |
A mechanism-based cross-linker for the identification of kinase-substrate pairs.
Topics: Adenosine; Adenosine Triphosphate; Binding Sites; Cross-Linking Reagents; Cysteine; o-Phthalaldehyde; Phosphorylation; Protein Kinases; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Serine; Substrate Specificity; Threonine | 2004 |
Role of disulfide bonds for the structure and folding of proguanylin.
Topics: Amino Acid Sequence; Amino Acid Substitution; Circular Dichroism; Cysteine; Disulfides; Gastrointestinal Hormones; Humans; Molecular Sequence Data; Natriuretic Peptides; Nitrogen Isotopes; Nuclear Magnetic Resonance, Biomolecular; Peptides; Protein Folding; Protein Precursors; Protein Sorting Signals; Recombinant Proteins; Serine; Structure-Activity Relationship | 2004 |
Only a portion of the small seatbelt loop in human choriogonadotropin appears capable of contacting the lutropin receptor.
Topics: Amino Acid Sequence; Animals; Arginine; Aspartic Acid; Carbon; Chorionic Gonadotropin; COS Cells; Cross-Linking Reagents; Cysteine; Dimerization; Disulfides; Dose-Response Relationship, Drug; Follicle Stimulating Hormone; Humans; Hydrogen-Ion Concentration; Ligands; Luteinizing Hormone; Models, Molecular; Molecular Sequence Data; Mutagenesis, Site-Directed; Mutation; Protein Binding; Protein Structure, Tertiary; Radioimmunoassay; Receptors, Thyrotropin; Serine; Signal Transduction; Temperature; Threonine | 2004 |
5HT-2C receptor polymorphism in suicide victims. Association studies in German and Slavic populations.
Topics: Adult; Cysteine; Demography; Female; Gene Frequency; Genotype; Humans; Male; Middle Aged; Polymorphism, Genetic; Receptor, Serotonin, 5-HT2C; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Serine; Suicide; White People | 2004 |
The effect of sugar, amino acid, metal ion, and NaCl on model Maillard reaction under pH control.
Topics: Alanine; Amino Acids; Arabinose; Arginine; Aspartic Acid; Biochemistry; Carbohydrates; Colorimetry; Copper; Cysteine; Fructose; Glucose; Glutamic Acid; Glycine max; Hot Temperature; Hydrogen-Ion Concentration; Ions; Iron; Isoleucine; Leucine; Lysine; Maltose; Metals; Models, Chemical; Phenylalanine; Proline; Serine; Sodium Chloride; Temperature; Time Factors; Valine; Xylose | 2004 |
Characterization of the Arabidopsis thaliana Arath;CDC25 dual-specificity tyrosine phosphatase.
Topics: Amino Acid Sequence; Amino Acid Substitution; Arabidopsis; Arabidopsis Proteins; Arginine; Base Sequence; cdc25 Phosphatases; Cloning, Molecular; Codon; Conserved Sequence; Cysteine; DNA Primers; Escherichia coli; Magnetic Resonance Spectroscopy; Molecular Sequence Data; Mutation, Missense; Protein Structure, Secondary; Protein Tyrosine Phosphatases; Recombinant Proteins; Serine | 2004 |
Response to lysine intake in composition of body weight gain and efficiency of lysine utilization of growing male chickens from two genotypes.
Topics: Amino Acids; Animals; Body Composition; Chickens; Cysteine; Energy Metabolism; Genotype; Glycine; Isoleucine; Lipid Metabolism; Lysine; Male; Methionine; Proline; Proteins; Serine; Weight Gain | 2004 |
Mutation screening of the BARD1 gene: evidence for involvement of the Cys557Ser allele in hereditary susceptibility to breast cancer.
Topics: Alleles; Amino Acid Sequence; Breast Neoplasms; Cysteine; DNA Mutational Analysis; Female; Finland; Genetic Predisposition to Disease; Genetic Testing; Humans; Male; Middle Aged; Molecular Sequence Data; Mutation; Ovarian Neoplasms; Pedigree; Serine; Tumor Suppressor Proteins; Ubiquitin-Protein Ligases | 2004 |
Identification of a novel epitope in the thyroid-stimulating hormone receptor ectodomain acting as intramolecular signaling interface.
Topics: Amino Acid Motifs; Amino Acid Sequence; Animals; Asparagine; Aspartic Acid; Cell Line; Cell Membrane; Cell Separation; Computational Biology; COS Cells; Cyclic AMP; Cysteine; DNA, Complementary; Dose-Response Relationship, Drug; Epitopes; Flow Cytometry; Humans; Interleukin-8; Microscopy, Confocal; Models, Molecular; Molecular Sequence Data; Mutagenesis, Site-Directed; Mutation; Peptides; Protein Binding; Protein Conformation; Protein Structure, Secondary; Protein Structure, Tertiary; Receptors, Thyrotropin; Serine; Signal Transduction; Time Factors; Transfection | 2004 |
Kinetic characterization of the catalytic mechanism of methionine sulfoxide reductase B from Neisseria meningitidis.
Topics: Bacterial Proteins; Catalysis; Cysteine; Disulfides; Kinetics; Methionine; Methionine Sulfoxide Reductases; Mutagenesis, Site-Directed; Neisseria meningitidis; Oxidation-Reduction; Oxidoreductases; Serine; Substrate Specificity; Sulfenic Acids; Thioredoxins | 2004 |
Expression and purification of His-tagged rat mitochondrial short-chain 3-hydroxyacyl-CoA dehydrogenase wild-type and Ser137 mutant proteins.
Topics: 3-Hydroxyacyl CoA Dehydrogenases; Amino Acid Sequence; Animals; Circular Dichroism; Cloning, Molecular; Crystallography, X-Ray; Cysteine; Electrophoresis, Polyacrylamide Gel; Escherichia coli; Hydrogen-Ion Concentration; Kinetics; Mitochondria; Models, Chemical; Molecular Sequence Data; Mutagenesis, Site-Directed; Mutation; Nickel; Oxygen; Plasmids; Rats; Sequence Homology, Amino Acid; Serine; Threonine | 2004 |
The nuclear receptor co-repressor (N-CoR) utilizes repression domains I and III for interaction and co-repression with ETO.
Topics: Amino Acid Motifs; Amino Acid Sequence; Animals; Binding Sites; Blotting, Western; Cell Line; Cysteine; DNA; DNA-Binding Proteins; Dose-Response Relationship, Drug; Drosophila; Gene Deletion; Genes, Reporter; Glutathione Transferase; Humans; Immunoprecipitation; Molecular Sequence Data; Mutation; Nuclear Proteins; Nuclear Receptor Co-Repressor 1; Plasmids; Protein Binding; Protein Structure, Tertiary; Proto-Oncogene Proteins; Recombinant Fusion Proteins; Repressor Proteins; RUNX1 Translocation Partner 1 Protein; Sequence Homology, Amino Acid; Serine; Transcription Factors; Transcription, Genetic; Transfection; Translocation, Genetic; Zinc; Zinc Fingers | 2004 |
Critical catalytic functional groups in the mechanism of aspartate-beta-semialdehyde dehydrogenase.
Topics: Aspartate-Semialdehyde Dehydrogenase; Binding Sites; Catalysis; Catalytic Domain; Cysteine; Haemophilus influenzae; Kinetics; Models, Chemical; Models, Molecular; Mutation; Protein Binding; Protein Conformation; Protein Structure, Secondary; Protons; Serine | 2004 |
Ratjadone and leptomycin B block CRM1-dependent nuclear export by identical mechanisms.
Topics: Active Transport, Cell Nucleus; Alkylation; Amino Acid Substitution; Antifungal Agents; Cell Nucleus; Cysteine; Exportin 1 Protein; Fatty Acids, Unsaturated; Glutathione Transferase; HeLa Cells; Humans; Karyopherins; Microinjections; Pyrones; Receptors, Cytoplasmic and Nuclear; Recombinant Fusion Proteins; Serine | 2004 |
Palmitoylation of inducible nitric-oxide synthase at Cys-3 is required for proper intracellular traffic and nitric oxide synthesis.
Topics: Amino Acid Sequence; Animals; Anti-Bacterial Agents; Antifungal Agents; Biological Transport; Boron Compounds; Brefeldin A; Cell Line; Cells, Cultured; Cloning, Molecular; COS Cells; Cysteine; Escherichia coli; Fluorescent Dyes; Golgi Apparatus; Green Fluorescent Proteins; Hydroxylamine; Lysine; Mice; Molecular Sequence Data; Monensin; Mutagenesis, Site-Directed; Mutation; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Palmitic Acid; Proline; Protein Processing, Post-Translational; Recombinant Fusion Proteins; Recombinant Proteins; Serine; Time Factors; Transfection | 2004 |
Polyprotein cleavage mechanism of SARS CoV Mpro and chemical modification of the octapeptide.
Topics: Amino Acid Sequence; Binding Sites; Computer Simulation; Coronavirus 3C Proteases; Cysteine; Cysteine Endopeptidases; Drug Design; Glutamine; Histidine; Hydrogen Bonding; Models, Molecular; Molecular Biology; Molecular Structure; Peptides; Protein Conformation; Protein Structure, Tertiary; Quantum Theory; Serine; Severe Acute Respiratory Syndrome; Severe acute respiratory syndrome-related coronavirus; Static Electricity | 2004 |
Interactions of alkyltin salts with biological dithiols: dealkylation and induction of a regular beta-turn structure in peptides.
Topics: Alkylation; Cysteine; Hydrogen-Ion Concentration; Models, Molecular; Neuropeptides; Nuclear Magnetic Resonance, Biomolecular; Oligopeptides; Organotin Compounds; Peptide Fragments; Protein Structure, Secondary; Serine; Spectrometry, Mass, Electrospray Ionization; Sulfhydryl Compounds; Thermodynamics; Trimethyltin Compounds | 2004 |
The solvent-inaccessible Cys67 residue of HLA-B27 contributes to T cell recognition of HLA-B27/peptide complexes.
Topics: Aggrecans; Amino Acid Substitution; Animals; Antigen Presentation; CD8-Positive T-Lymphocytes; Cell Line; Cells, Cultured; Cysteine; Epitopes, T-Lymphocyte; Extracellular Matrix Proteins; Flow Cytometry; Herpesvirus 4, Human; HLA-B27 Antigen; Humans; Immunodominant Epitopes; Lectins, C-Type; Mice; Mice, Inbred BALB C; Mice, Transgenic; Peptide Fragments; Protein Binding; Protein Folding; Proteoglycans; Receptors, Immunologic; Serine; Solvents; Transfection | 2004 |
Mutations in the pore region modify epithelial sodium channel gating by shear stress.
Topics: Amiloride; Amino Acid Sequence; Animals; Binding Sites; Cysteine; Electrophysiology; Epithelial Sodium Channels; Glycine; Kinetics; Leucine; Mice; Models, Chemical; Molecular Sequence Data; Mutation; Oocytes; Patch-Clamp Techniques; Protein Structure, Tertiary; RNA, Complementary; Serine; Sodium; Sodium Channels; Stress, Mechanical; Time Factors; Tryptophan; Xenopus laevis | 2005 |
Cysteine-scanning mutagenesis of muscle carnitine palmitoyltransferase I reveals a single cysteine residue (Cys-305) is important for catalysis.
Topics: Alanine; Amino Acid Sequence; Animals; Binding Sites; Blotting, Western; Carnitine; Carnitine O-Palmitoyltransferase; Catalysis; Cysteine; DNA Primers; Humans; Kinetics; Malonyl Coenzyme A; Models, Chemical; Molecular Sequence Data; Mutagenesis; Mutation; Myocardium; Palmitic Acid; Palmitoylcarnitine; Pichia; Protein Structure, Tertiary; Sequence Homology, Amino Acid; Serine | 2005 |
Mechanistic studies on phosphopantothenoylcysteine decarboxylase: trapping of an enethiolate intermediate with a mechanism-based inactivating agent.
Topics: Binding Sites; Carboxy-Lyases; Catalysis; Cysteine; Decarboxylation; Enzyme Inhibitors; Enzyme Stability; Flavin Mononucleotide; Humans; Kinetics; Mutagenesis, Site-Directed; Pantetheine; Pantothenic Acid; Serine; Spectrometry, Mass, Electrospray Ionization; Substrate Specificity; Sulfhydryl Compounds | 2004 |
Substrate-trapping techniques in the identification of cellular PTP targets.
Topics: Alanine; Aspartic Acid; Catalytic Domain; Cysteine; Glutathione; Mutation; Protein Tyrosine Phosphatases; Recombinant Fusion Proteins; Serine; Substrate Specificity; Vanadates | 2005 |
Novel germline mutation in the transmembrane region of RET gene close to Cys634Ser mutation associated with MEN 2A syndrome.
Topics: Adrenal Gland Neoplasms; Carcinoma, Medullary; Cysteine; Exons; Female; Gene Frequency; Genetic Linkage; Germ-Line Mutation; Humans; Male; Multiple Endocrine Neoplasia Type 2a; Oncogene Proteins; Pedigree; Pheochromocytoma; Proto-Oncogene Proteins c-ret; Receptor Protein-Tyrosine Kinases; Serine; Thyroid Neoplasms | 2005 |
The selectivity for cysteine over serine in coenzyme A biosynthesis.
Topics: Carboxy-Lyases; Chromatography, High Pressure Liquid; Coenzyme A; Cysteine; Molecular Structure; Multienzyme Complexes; Peptide Synthases; Serine | 2005 |
Coordination chemistry at the molybdenum site of sulfite oxidase: redox-induced structural changes in the cysteine 207 to serine mutant.
Topics: Binding Sites; Cysteine; Electron Spin Resonance Spectroscopy; Humans; Molecular Structure; Molybdenum; Mutation; Oxidation-Reduction; Oxidoreductases Acting on Sulfur Group Donors; Protein Conformation; Serine | 2004 |
Side chain orientation of residues lining the selectivity filter of epithelial Na+ channels.
Topics: Alanine; Amiloride; Amino Acid Sequence; Animals; Binding Sites; Cadmium; Cations; Cysteine; Dithiothreitol; Dose-Response Relationship, Drug; Electrophysiology; Epithelial Sodium Channels; Mice; Models, Biological; Models, Molecular; Molecular Sequence Data; Mutagenesis, Site-Directed; Mutation; Oocytes; Protein Binding; Protein Structure, Tertiary; RNA, Complementary; Sequence Homology, Amino Acid; Serine; Sodium Channels; Time Factors; Xenopus | 2005 |
Ethacrynic acid inhibits multiple steps in the NF-kappaB signaling pathway.
Topics: Animals; Anti-Inflammatory Agents; Blotting, Western; Cell Line; Cell Nucleus; Cell Survival; Cell-Free System; Cysteine; Cytosol; Dimerization; DNA; Dose-Response Relationship, Drug; Enzyme Inhibitors; Ethacrynic Acid; Genes, Reporter; Glutathione; Humans; I-kappa B Proteins; Inflammation; Lipopolysaccharides; Mice; Models, Chemical; Models, Molecular; NF-kappa B; NF-kappa B p50 Subunit; NF-KappaB Inhibitor alpha; Phosphorylation; Recombinant Proteins; Reverse Transcriptase Polymerase Chain Reaction; Serine; Signal Transduction; Transcription Factor RelA; Transcription Factors | 2005 |
Identification of a membrane-localized cysteine cluster near the substrate-binding sites of the Streptococcus equisimilis hyaluronan synthase.
Topics: Alanine; Binding Sites; Carbon Isotopes; Cell Membrane; Cysteine; Glucuronosyltransferase; Hyaluronan Synthases; Isotope Labeling; Models, Molecular; Mutagenesis, Site-Directed; Point Mutation; Protein Binding; Serine; Streptococcus equi; Structure-Activity Relationship | 2005 |
S-nitrosylation-dependent inactivation of Akt/protein kinase B in insulin resistance.
Topics: 3T3 Cells; Adipocytes; Animals; Cell Line, Tumor; Cells, Cultured; COS Cells; Cysteine; Diabetes Mellitus, Experimental; DNA, Complementary; Extracellular Signal-Regulated MAP Kinases; Immunoblotting; Insulin Resistance; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Muscle, Skeletal; Mutation; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitrogen; Oxidative Stress; Penicillamine; Phosphatidylinositol 3-Kinases; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Serine; Signal Transduction; Time Factors; Transfection | 2005 |
Specificity and reactive loop length requirements for crmA inhibition of serine proteases.
Topics: Antithrombins; Arginine; Binding Sites; Chromatography; Cysteine; Dose-Response Relationship, Drug; Electrophoresis, Polyacrylamide Gel; Enzyme Inhibitors; Escherichia coli; Factor Xa; Kinetics; Mutagenesis; Pancreatic Elastase; Peptide Hydrolases; Protein Binding; Protein Conformation; Protein Folding; Protein Structure, Tertiary; Serine; Serine Endopeptidases; Serine Proteinase Inhibitors; Serpins; Time Factors; Trypsin; Viral Proteins | 2005 |
Engineering of a recombinant vitamin K-dependent gamma-carboxylation system with enhanced gamma-carboxyglutamic acid forming capacity: evidence for a functional CXXC redox center in the system.
Topics: Animals; Binding Sites; Blotting, Western; Carboxylic Acids; Cell Line; Cell Line, Tumor; Cloning, Molecular; Cricetinae; Cysteine; DNA; DNA, Complementary; Electrophoresis, Gel, Two-Dimensional; Electrophoresis, Polyacrylamide Gel; Factor X; Genetic Vectors; Liver; Male; Microsomes; Microsomes, Liver; Mixed Function Oxygenases; Mutagenesis, Site-Directed; Mutation; Oxidation-Reduction; Peptides; Plasmids; Protein Engineering; Protein Structure, Tertiary; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Serine; Thioredoxins; Transfection; Vitamin K; Vitamin K Epoxide Reductases | 2005 |
Identification of residues that contribute to receptor activation through the analysis of compensatory mutations in the G protein-coupled alpha-factor receptor.
Topics: Alanine; Amino Acid Sequence; Cysteine; DNA Mutational Analysis; Genes, Suppressor; Genetic Testing; Mating Factor; Molecular Sequence Data; Mutagenesis; Peptides; Phenylalanine; Receptors, G-Protein-Coupled; Receptors, Mating Factor; Receptors, Peptide; Saccharomyces cerevisiae Proteins; Serine; Signal Transduction; Threonine; Transcription Factors; Tyrosine | 2005 |
Asymmetric interaction between rod cyclic GMP phosphodiesterase gamma subunits and alphabeta subunits.
Topics: 3',5'-Cyclic-GMP Phosphodiesterases; Animals; Biotin; Blotting, Western; Catalysis; Catalytic Domain; Cattle; Cross-Linking Reagents; Cyclic Nucleotide Phosphodiesterases, Type 6; Cysteine; Dimerization; Dose-Response Relationship, Drug; Electrophoresis, Polyacrylamide Gel; Eye Proteins; Light; Mass Spectrometry; Models, Biological; Models, Chemical; Peptides; Phosphoric Diester Hydrolases; Protein Binding; Protein Structure, Tertiary; Retinal Rod Photoreceptor Cells; Serine; Ultraviolet Rays; Vision, Ocular | 2005 |
In the quest for stable rescuing mutants of p53: computational mutagenesis of flexible loop L1.
Topics: Amino Acid Substitution; Computational Biology; Computer Simulation; Cysteine; Humans; Hydrogen Bonding; Methionine; Models, Molecular; Mutagenesis, Site-Directed; Neoplasm Proteins; Proline; Protein Conformation; Protein Structure, Secondary; Serine; Thermodynamics; Tumor Suppressor Protein p53 | 2005 |
Contributions of cysteine residues in Zn2 to zinc fingers and thiol-disulfide oxidoreductase activities of chaperone DnaJ.
Topics: Amino Acid Motifs; Amino Acid Sequence; Amino Acid Substitution; Binding Sites; Catalysis; Cysteine; Escherichia coli Proteins; Heat-Shock Proteins; Histidine; HSP40 Heat-Shock Proteins; Molecular Chaperones; Molecular Sequence Data; Peptide Fragments; Protein Conformation; Protein Disulfide Reductase (Glutathione); Protein Structure, Tertiary; Serine; Zinc; Zinc Fingers | 2005 |
Specific cross-linking of Lys233 and Cys235 in the mu opioid receptor by a reporter affinity label.
Topics: Arginine; Binding, Competitive; Cell Line; Cross-Linking Reagents; Cysteine; Fluorometry; Genes, Reporter; Humans; Kinetics; Lysine; Mutagenesis, Site-Directed; Naphthalenes; Photoaffinity Labels; Protein Binding; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Serine | 2005 |
Alpha 1-antitrypsin polymerization: a fluorescence correlation spectroscopic study.
Topics: alpha 1-Antitrypsin; Cysteine; Diffusion; Electrophoresis, Polyacrylamide Gel; Humans; Microscopy, Confocal; Mutagenesis, Site-Directed; Peptide Fragments; Polymers; Protein Denaturation; Serine; Spectrometry, Fluorescence; Temperature; Time Factors | 2005 |
Palmitoylated cysteine 192 is required for RhoB tumor-suppressive and apoptotic activities.
Topics: Alanine; Amino Acid Sequence; Apoptosis; Blotting, Western; Cell Cycle Proteins; Cell Line; Cell Line, Tumor; Cell Proliferation; Coloring Agents; Cyclin-Dependent Kinase Inhibitor p21; Cysteine; DNA Primers; Genes, Tumor Suppressor; Glycine; Humans; In Situ Nick-End Labeling; Molecular Sequence Data; Mutagenesis, Site-Directed; Mutation; Palmitic Acid; Promoter Regions, Genetic; Protein Biosynthesis; Protein Prenylation; rhoA GTP-Binding Protein; rhoB GTP-Binding Protein; Sequence Homology, Amino Acid; Serine; Tetrazolium Salts; Thiazoles; Transcription Factor AP-1; Transcription, Genetic; Transfection; Transforming Growth Factor beta | 2005 |
Cysteine-to-serine mutants of the human copper chaperone for superoxide dismutase reveal a copper cluster at a domain III dimer interface.
Topics: Amino Acid Sequence; Amino Acid Substitution; Copper; Cysteine; Dimerization; Enzyme Activation; Humans; Molecular Chaperones; Molecular Sequence Data; Mutagenesis, Site-Directed; Protein Binding; Protein Structure, Tertiary; Recombinant Fusion Proteins; Serine; Spectrum Analysis; Superoxide Dismutase; X-Rays; Zinc | 2005 |
Insights into the base catalysis exerted by the DD-transpeptidase from Streptomyces K15: a molecular dynamics study.
Topics: Binding Sites; Catalysis; Computer Simulation; Crystallization; Crystallography, X-Ray; Cysteine; Enzyme Stability; Lysine; Models, Chemical; Models, Molecular; Penicillin G; Penicillin-Binding Proteins; Quantum Theory; Serine; Serine-Type D-Ala-D-Ala Carboxypeptidase; Streptomyces; Thermodynamics | 2005 |
Crystal structure of S-ribosylhomocysteinase (LuxS) in complex with a catalytic 2-ketone intermediate.
Topics: Alanine; Arginine; Bacillus subtilis; Bacterial Proteins; Binding Sites; Carbon-Sulfur Lyases; Catalysis; Cobalt; Crystallization; Crystallography, X-Ray; Cysteine; Ferrous Compounds; Histidine; Homocysteine; Hydrolases; Ketones; Models, Molecular; Mutagenesis, Site-Directed; Serine; Spectrophotometry, Ultraviolet; Substrate Specificity; Vibrio | 2005 |
Protein kinase D specifically mediates apoptosis signal-regulating kinase 1-JNK signaling induced by H2O2 but not tumor necrosis factor.
Topics: 14-3-3 Proteins; Animals; Apoptosis; Blotting, Western; Carbazoles; Cattle; Cysteine; Cytoplasm; Dose-Response Relationship, Drug; Endothelium, Vascular; Humans; Hydrogen Peroxide; Indoles; JNK Mitogen-Activated Protein Kinases; Maleimides; MAP Kinase Kinase Kinase 5; Models, Biological; Naphthalenes; Phosphorylation; Protein Binding; Protein Isoforms; Protein Kinase C; Protein Structure, Tertiary; RNA, Small Interfering; Serine; Signal Transduction; Staurosporine; Time Factors; Transfection; Tumor Necrosis Factor-alpha; Umbilical Veins | 2005 |
Identification and functional characterization of a novel low affinity aromatic-preferring amino acid transporter (arpAT). One of the few proteins silenced during primate evolution.
Topics: Alanine; Amino Acid Sequence; Amino Acid Transport Systems; Amino Acid Transport Systems, Neutral; Amino Acids; Amino Acids, Aromatic; Animals; Arginine; Biological Transport; Blotting, Northern; Blotting, Western; Cell Lineage; Chickens; Cloning, Molecular; Cysteine; Dimerization; DNA, Complementary; Dogs; Dose-Response Relationship, Drug; Evolution, Molecular; Gene Library; Gene Silencing; Glutamine; Glycine; HeLa Cells; Humans; In Situ Hybridization; Inhibitory Concentration 50; Intestine, Small; Kidney; Kinetics; Levodopa; Mice; Molecular Sequence Data; Open Reading Frames; Pan troglodytes; Phylogeny; Proline; Protein Binding; Rats; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Serine; Sodium; Transfection | 2005 |
The alpha-helical propensity of the cytoplasmic domain of phospholamban: a molecular dynamics simulation of the effect of phosphorylation and mutation.
Topics: Algorithms; Amino Acid Motifs; Amino Acid Sequence; Animals; Arginine; Calcium; Calcium-Binding Proteins; Calcium-Transporting ATPases; Circular Dichroism; Computer Simulation; Cysteine; Cytoplasm; Magnetic Resonance Spectroscopy; Models, Molecular; Molecular Sequence Data; Mutation; Myocardium; Peptides; Phosphorylation; Proline; Protein Conformation; Protein Denaturation; Protein Folding; Protein Structure, Secondary; Protein Structure, Tertiary; Sarcoplasmic Reticulum; Serine; Temperature | 2005 |
Serine 16 phosphorylation induces an order-to-disorder transition in monomeric phospholamban.
Topics: Alanine; Amino Acid Sequence; Calcium-Binding Proteins; Calcium-Transporting ATPases; Cysteine; Enzyme Inhibitors; Molecular Sequence Data; Mutation; Nitrogen Isotopes; Nuclear Magnetic Resonance, Biomolecular; Phosphorylation; Protein Conformation; Sarcoplasmic Reticulum; Sarcoplasmic Reticulum Calcium-Transporting ATPases; Serine; Solutions; Structure-Activity Relationship; Thermodynamics | 2005 |
The solution structure of the FATC domain of the protein kinase target of rapamycin suggests a role for redox-dependent structural and cellular stability.
Topics: Amino Acid Sequence; Animals; Binding Sites; Conserved Sequence; Cysteine; Disulfides; Drug Stability; Magnetic Resonance Spectroscopy; Models, Molecular; Molecular Sequence Data; Mutagenesis; Oxidation-Reduction; Peptide Fragments; Phosphatidylinositol 3-Kinases; Phosphotransferases (Alcohol Group Acceptor); Protein Structure, Secondary; Recombinant Fusion Proteins; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Sequence Alignment; Serine; Sirolimus; Structure-Activity Relationship; Temperature | 2005 |
Novel aggregate formation of a frame-shift mutant protein of tissue-nonspecific alkaline phosphatase is ascribed to three cysteine residues in the C-terminal extension. Retarded secretion and proteasomal degradation.
Topics: Alkaline Phosphatase; Cysteine; Frameshift Mutation; Octoxynol; Polyethylene Glycols; Proteasome Endopeptidase Complex; Serine; Ubiquitin | 2005 |
Polymorphisms of the receptor of advanced glycation endproducts (RAGE) and the development of nephropathy in type 1 diabetic patients.
Topics: Amino Acid Substitution; Arginine; Cross-Sectional Studies; Cysteine; Diabetes Mellitus, Type 1; Diabetic Nephropathies; Exons; Female; Genotype; Glycine; Humans; Male; Polymerase Chain Reaction; Polymorphism, Genetic; Polymorphism, Restriction Fragment Length; Receptor for Advanced Glycation End Products; Receptors, Immunologic; Serine | 2005 |
Identification of amino acids required for the functional up-regulation of human dihydrofolate reductase protein in response to antifolate Treatment.
Topics: Amino Acids; Animals; Binding Sites; Blotting, Western; Catalysis; Cell Survival; CHO Cells; Cloning, Molecular; Cricetinae; Cysteine; DNA Primers; Folic Acid Antagonists; Gene Expression Regulation, Enzymologic; Glutamic Acid; Glutathione Transferase; Green Fluorescent Proteins; Humans; Inhibitory Concentration 50; Kinetics; Leucine; Methotrexate; Microscopy, Fluorescence; Models, Biological; Mutagenesis, Site-Directed; Mutation; NADP; Protein Biosynthesis; Recombinant Fusion Proteins; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Serine; Spectrophotometry; Tetrahydrofolate Dehydrogenase; Time Factors; Transcription, Genetic; Transfection; Up-Regulation | 2005 |
Substitution of the cysteine 438 residue in the cytoplasmic tail of the glucagon-like peptide-1 receptor alters signal transduction activity.
Topics: Adenylyl Cyclases; Alanine; Animals; CHO Cells; Consensus Sequence; Cricetinae; Cyclic AMP; Cysteine; Cytoplasm; Endocytosis; Female; Glucagon-Like Peptide-1 Receptor; GTP-Binding Proteins; Mutagenesis, Site-Directed; Mutation; Palmitates; Protein Kinase C; Rats; Receptors, Glucagon; Serine; Signal Transduction; Transfection | 2005 |
Resolution of two substrate-binding sites in an engineered cytochrome P450eryF bearing a fluorescent probe.
Topics: Allosteric Site; Bacterial Proteins; Binding Sites; Biophysics; Crystallography, X-Ray; Cysteine; Cytochrome P-450 Enzyme System; DNA Primers; Dose-Response Relationship, Drug; Escherichia coli; Fluorescence Resonance Energy Transfer; Fluorescent Dyes; Ions; Kinetics; Mixed Function Oxygenases; Models, Chemical; Models, Molecular; Mutagenesis, Site-Directed; Mutation; Protein Binding; Protein Conformation; Protein Engineering; Protein Structure, Secondary; Pyrenes; Saccharopolyspora; Salts; Serine; Spectrometry, Fluorescence; Substrate Specificity | 2005 |
Large-scale investigation of base excision repair genetic polymorphisms and lung cancer risk in a multicenter study.
Topics: Adenocarcinoma; Adult; Aged; Arginine; Case-Control Studies; Confounding Factors, Epidemiologic; Cysteine; DNA Repair; Europe, Eastern; Female; Genotype; Humans; Logistic Models; Lung Neoplasms; Male; Middle Aged; Multivariate Analysis; Odds Ratio; Polymorphism, Genetic; Research Design; Risk Assessment; Risk Factors; Selection Bias; Serine; Smoking; Tryptophan | 2005 |
Point mutations at the type I Cu ligands, Cys457 and Met467, and at the putative proton donor, Asp105, in Myrothecium verrucaria bilirubin oxidase and reactions with dioxygen.
Topics: Alanine; Amino Acid Substitution; Asparagine; Aspartic Acid; Copper; Cysteine; Dithionite; Fungal Proteins; Glutamic Acid; Glutamine; Hypocreales; Ligands; Methionine; Oxidation-Reduction; Oxidoreductases Acting on CH-CH Group Donors; Oxygen; Point Mutation; Protons; Serine | 2005 |
Characterization of a transient covalent adduct formed during dimethylarginine dimethylaminohydrolase catalysis.
Topics: Acids; Amidohydrolases; Amino Acid Sequence; Catalysis; Cysteine; DNA Adducts; Hydrolysis; Kinetics; Molecular Sequence Data; Mutagenesis, Site-Directed; Peptide Fragments; Pseudomonas aeruginosa; Serine; Spectrometry, Mass, Electrospray Ionization; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Substrate Specificity | 2005 |
Pronounced conformational changes following agonist activation of the M(3) muscarinic acetylcholine receptor.
Topics: Amino Acid Sequence; Animals; Atropine; Blotting, Western; Carbachol; Cell Membrane; COS Cells; Cross-Linking Reagents; Cysteine; Disulfides; Electrophoresis, Polyacrylamide Gel; Factor Xa; Kinetics; Ligands; Models, Molecular; Molecular Sequence Data; Mutation; Oxygen; Phosphatidylinositols; Protein Binding; Protein Conformation; Protein Structure, Secondary; Protein Structure, Tertiary; Rats; Receptor, Muscarinic M3; Serine; Signal Transduction; Transfection; Valine | 2005 |
Molybdenum oxides as highly effective dehydrative cyclization catalysts for the synthesis of oxazolines and thiazolines.
Topics: Catalysis; Cyclization; Cysteine; Molybdenum; Oxazoles; Serine; Thiazoles; Threonine | 2005 |
The phot LOV2 domain and its interaction with LOV1.
Topics: Animals; Anions; Cations; Chlamydomonas reinhardtii; Cryptochromes; Cysteine; DNA Adducts; Flavoproteins; Hot Temperature; Hydrogen-Ion Concentration; Ions; Kinetics; Light; Models, Chemical; Mutation; Photons; Photoreceptor Cells, Invertebrate; Protein Binding; Protein Structure, Tertiary; Serine; Sodium Chloride; Spectrophotometry; Temperature; Time Factors | 2005 |
Mechanism of zinc coordination by point-mutated structures of the distal CCHC binding motif of the HIV-1 NCp7 protein.
Topics: Alanine; Amino Acid Motifs; Amino Acid Sequence; Capsid Proteins; Cysteine; gag Gene Products, Human Immunodeficiency Virus; Gene Products, gag; Histidine; HIV-1; Hydrogen-Ion Concentration; Kinetics; Models, Chemical; Molecular Sequence Data; Peptide Fragments; Point Mutation; Protein Binding; Serine; Spectrometry, Fluorescence; Viral Proteins; Zinc | 2005 |
Redox regulation of a soybean tyrosine-specific protein phosphatase.
Topics: Amino Acid Sequence; Binding Sites; Cysteine; Disulfides; Glutathione; Glycine max; Molecular Sequence Data; Mutagenesis, Site-Directed; Oxidation-Reduction; Plant Proteins; Protein Tyrosine Phosphatases; Recombinant Proteins; Serine | 2005 |
Site-directed disulfide mapping of residues contributing to the Ca2+ and K+ binding pocket of the NCKX2 Na+/Ca2+-K+ exchanger.
Topics: Amino Acid Sequence; Aspartic Acid; Binding Sites; Calcium; Cell Line; Cell Membrane; Cross-Linking Reagents; Cysteine; Disulfides; Glutamic Acid; Humans; Hydrolysis; Hydrophobic and Hydrophilic Interactions; Molecular Sequence Data; Mutagenesis, Insertional; Peptide Mapping; Phenanthrolines; Potassium; Protein Sorting Signals; Protein Structure, Secondary; Repetitive Sequences, Amino Acid; Serine; Sodium-Calcium Exchanger | 2005 |
Pharmacological properties of the Cys23Ser single nucleotide polymorphism in human 5-HT2C receptor isoforms.
Topics: Animals; Binding, Competitive; Cell Line; Chlorocebus aethiops; Cysteine; Dose-Response Relationship, Drug; Humans; Ligands; Mice; Mutagenesis, Site-Directed; Polymorphism, Single Nucleotide; Protein Isoforms; Receptor, Serotonin, 5-HT2C; Serine; Serotonin 5-HT2 Receptor Agonists; Serotonin 5-HT2 Receptor Antagonists; Serotonin Antagonists; Serotonin Receptor Agonists; Transfection | 2005 |
Impact of elevated H(2)S on metabolite levels, activity of enzymes and expression of genes involved in cysteine metabolism.
Topics: Arabidopsis; Blotting, Northern; Blotting, Western; Carbon-Oxygen Lyases; Cystathionine gamma-Lyase; Cysteine; Dose-Response Relationship, Drug; Enzymes; Fumigation; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Plant; Hydrogen Sulfide; Phenotype; Serine; Sulfurtransferases | 2005 |
Structural bioinformatics-based design of selective, irreversible kinase inhibitors.
Topics: Amino Acid Sequence; Animals; Binding Sites; Computational Biology; COS Cells; Cysteine; Cytidine Deaminase; Enzyme Inhibitors; Epidermal Growth Factor; Heterocyclic Compounds, 2-Ring; Histones; Hydrophobic and Hydrophilic Interactions; Molecular Structure; Mutation; Phosphorylation; Protein Structure, Tertiary; Ribosomal Protein S6 Kinases, 90-kDa; Sequence Alignment; Serine; Structure-Activity Relationship; Threonine | 2005 |
The crystal structure of Mlc, a global regulator of sugar metabolism in Escherichia coli.
Topics: Alanine; Arthrobacter; Bacillus subtilis; beta-Galactosidase; Binding Sites; Carbohydrate Metabolism; Cloning, Molecular; Crystallography, X-Ray; Cysteine; Databases, Protein; Dimerization; Escherichia coli; Escherichia coli Proteins; Fructokinases; Glucokinase; Glucose; Models, Molecular; Mutagenesis, Site-Directed; Mutation; Phosphoenolpyruvate Sugar Phosphotransferase System; Phosphorylation; Protein Binding; Protein Conformation; Protein Structure, Tertiary; Repressor Proteins; Serine; Transcription, Genetic; Zinc | 2005 |
D-Serine uptake by isolated retinas is consistent with ASCT-mediated transport.
Topics: 4-Chloro-7-nitrobenzofurazan; Alanine; Ambystoma; Amino Acid Transport System ASC; Animals; Biological Transport; Cysteine; Electrophoresis, Capillary; In Vitro Techniques; Retina; Serine; Sodium; Threonine; Time Factors | 2005 |
Wild-type-like viral replication potential of human immunodeficiency virus type 1 envelope mutants lacking palmitoylation signals.
Topics: Amino Acid Sequence; Amino Acid Substitution; Base Sequence; Binding Sites; Cysteine; DNA Primers; Gene Products, env; HIV-1; Humans; Palmitic Acid; Plasmids; Reference Values; Sequence Deletion; Serine; Virus Replication | 2005 |
Ubiquitination on nonlysine residues by a viral E3 ubiquitin ligase.
Topics: Amino Acid Motifs; Amino Acid Sequence; Animals; Cell Line; CHO Cells; Cricetinae; Cysteine; Down-Regulation; Endocytosis; Herpesvirus 8, Human; HLA-B7 Antigen; Humans; Lysine; Mutation; Protein Structure, Tertiary; Serine; Transduction, Genetic; Ubiquitin; Ubiquitin-Protein Ligases | 2005 |
Individual palmitoyl residues serve distinct roles in H-ras trafficking, microlocalization, and signaling.
Topics: Animals; Cell Line; Cell Membrane; Cricetinae; Cysteine; Extracellular Signal-Regulated MAP Kinases; Genes, ras; Golgi Apparatus; Kinetics; MAP Kinase Kinase Kinases; Mutation; Oncogene Protein p21(ras); Palmitic Acids; PC12 Cells; Protein Transport; raf Kinases; Rats; Serine | 2005 |
Characterization of an Escherichia coli sulfite oxidase homologue reveals the role of a conserved active site cysteine in assembly and function.
Topics: Binding Sites; Computational Biology; Conserved Sequence; Cysteine; Electron Spin Resonance Spectroscopy; Escherichia coli Proteins; Histidine; Mutagenesis, Site-Directed; Oligopeptides; Oxidoreductases; Oxidoreductases Acting on Sulfur Group Donors; Protein Processing, Post-Translational; Serine; Structural Homology, Protein; Substrate Specificity; Tungsten | 2005 |
Salt-dependent intra- and internucleosomal interactions of the H3 tail domain in a model oligonucleosomal array.
Topics: Amino Acid Substitution; Animals; Binding Sites; Cross-Linking Reagents; Cysteine; Dimerization; DNA; Dose-Response Relationship, Drug; Histones; Magnesium; Models, Biological; Models, Chemical; Nucleosomes; Phosphorus Radioisotopes; Protein Binding; Protein Structure, Tertiary; Recombinant Proteins; Serine; Sodium Chloride; Templates, Genetic; Ultraviolet Rays; Xenopus | 2005 |
Prenylation-defective human connexin32 mutants are normally localized and function equivalently to wild-type connexin32 in myelinating Schwann cells.
Topics: Amino Acid Motifs; Animals; Codon, Terminator; Connexins; Conserved Sequence; Cysteine; DNA; Evolution, Molecular; Female; Femoral Nerve; Gap Junction beta-1 Protein; Glycine; Humans; Male; Mice; Mice, Transgenic; Mutation; Myelin Sheath; Phenotype; Protein Prenylation; Schwann Cells; Sciatic Nerve; Serine; Tissue Distribution | 2005 |
Identification of an agonist-induced conformational change occurring adjacent to the ligand-binding pocket of the M(3) muscarinic acetylcholine receptor.
Topics: Amino Acid Sequence; Animals; Asparagine; Binding Sites; Blotting, Western; Carbachol; Cell Membrane; Chlorocebus aethiops; COS Cells; Cross-Linking Reagents; Cysteine; Disulfides; Dose-Response Relationship, Drug; Kinetics; Leucine; Ligands; Luciferases; Models, Chemical; Models, Molecular; Molecular Sequence Data; Mutagenesis, Site-Directed; Mutation; Oxygen; Phosphatidylinositols; Protein Binding; Protein Conformation; Protein Structure, Tertiary; Rats; Receptors, Muscarinic; Serine; Transfection | 2005 |
Structure and function of lysosomal phospholipase A2: identification of the catalytic triad and the role of cysteine residues.
Topics: Alanine; Amino Acid Sequence; Animals; Aspartic Acid; Brain; Catalysis; Catalytic Domain; Cattle; Chlorocebus aethiops; Chromatography; COS Cells; Cysteine; Disulfides; Electrophoresis, Polyacrylamide Gel; Histidine; Humans; Immunoblotting; Kidney; Lysosomes; Macrophages; Mice; Molecular Sequence Data; Mutagenesis, Site-Directed; Mutation; Open Reading Frames; Phosphatidylcholines; Phosphatidylethanolamines; Phospholipases A; Phospholipases A2; Phospholipids; Plasmids; Pulmonary Surfactants; Rats; Sequence Homology, Amino Acid; Serine; Surface-Active Agents; Transfection | 2005 |
Hb Oegstgeest [alpha104(G11)Cys-->Ser (alpha1)]. A new hemoglobin variant associated with a mild alpha-thalassemia phenotype.
Topics: alpha-Thalassemia; Amino Acid Substitution; Anemia, Hypochromic; Child; Cysteine; Female; Hemoglobins, Abnormal; Humans; Phenotype; Point Mutation; Serine | 2005 |
The signature amidase from Sulfolobus solfataricus belongs to the CX3C subgroup of enzymes cleaving both amides and nitriles. Ser195 and Cys145 are predicted to be the active site nucleophiles.
Topics: Amides; Amidohydrolases; Amino Acid Sequence; Binding Sites; Catalytic Domain; Cysteine; Models, Molecular; Mutation; Nitriles; Protein Conformation; Serine; Sulfolobus solfataricus; Temperature | 2005 |
Molecular basis of cysteine biosynthesis in plants: structural and functional analysis of O-acetylserine sulfhydrylase from Arabidopsis thaliana.
Topics: Amino Acid Sequence; Arabidopsis; Asparagine; Binding Sites; Cloning, Molecular; Crystallography, X-Ray; Cysteine; Cysteine Synthase; Cytosol; Databases, Protein; Glutamine; Kinetics; Ligands; Methionine; Models, Chemical; Models, Molecular; Molecular Sequence Data; Mutagenesis, Site-Directed; Mutation; Plant Proteins; Protein Binding; Protein Conformation; Pyridoxal Phosphate; Sequence Homology, Amino Acid; Serine; Serine O-Acetyltransferase; Threonine | 2005 |
A redox-sensitive cysteine in Zta is required for Epstein-Barr virus lytic cycle DNA replication.
Topics: Amino Acid Sequence; Amino Acid Substitution; Cell Line; Cysteine; DNA Replication; DNA-Binding Proteins; DNA, Viral; Herpesvirus 4, Human; Humans; Molecular Sequence Data; Oxidation-Reduction; Sequence Alignment; Serine; Trans-Activators; Up-Regulation; Viral Proteins; Virus Replication | 2005 |
Cement proteins of the tube-building polychaete Phragmatopoma californica.
Topics: Amino Acid Sequence; Amino Acids; Animals; Cross-Linking Reagents; Cysteine; DNA, Complementary; In Situ Hybridization; Microscopy, Electron, Scanning; Models, Biological; Models, Molecular; Molecular Sequence Data; Peptides; Polychaeta; Polymerase Chain Reaction; Protein Structure, Tertiary; Reverse Transcriptase Polymerase Chain Reaction; Serine; Spectrometry, Mass, Electrospray Ionization; Time Factors | 2005 |
Isomers of epidermal growth factor with Ser --> Cys mutation at the N-terminal sequence: isomerization, stability, unfolding, refolding, and structure.
Topics: Amino Acid Sequence; Cysteine; Disulfides; Epidermal Growth Factor; Humans; Isomerism; Models, Molecular; Molecular Sequence Data; Mutagenesis, Site-Directed; Mutation; Protein Conformation; Protein Denaturation; Protein Folding; Serine | 2005 |
Membrane topology of mouse stearoyl-CoA desaturase 1.
Topics: Amino Acid Sequence; Amino Acids; Animals; Catalysis; Cell Membrane; Cysteine; DNA Primers; Endopeptidase K; Endoplasmic Reticulum; Epitopes; Fluorescent Antibody Technique, Indirect; HeLa Cells; Humans; Immunoblotting; Mice; Microscopy, Fluorescence; Molecular Sequence Data; Mutation; Octoxynol; Plasmids; Protein Binding; Protein Conformation; Protein Isoforms; Protein Structure, Secondary; Protein Structure, Tertiary; Recombinant Proteins; Serine; Stearoyl-CoA Desaturase | 2006 |
Biochemical and functional characterization of phosphoserine aminotransferase from Entamoeba histolytica, which possesses both phosphorylated and non-phosphorylated serine metabolic pathways.
Topics: Amino Acid Sequence; Animals; Cysteine; Entamoeba histolytica; Molecular Sequence Data; Phosphorylation; Phylogeny; Recombinant Proteins; Sequence Alignment; Serine; Transaminases | 2006 |
Mimicking reverse protein splicing by three-segment tandem peptide ligation.
Topics: Amino Acid Sequence; Cysteine; Inteins; Models, Chemical; Molecular Sequence Data; Peptide Fragments; Protein Engineering; Protein Splicing; Serine; Threonine | 2005 |
Identification of constitutive phosphorylation sites on the Epstein-Barr virus ZEBRA protein.
Topics: Binding Sites; Biochemistry; Cell Line, Tumor; Cell Movement; Cysteine; DNA-Binding Proteins; Escherichia coli; Genetic Vectors; Herpesvirus 4, Human; Humans; Immunoprecipitation; JNK Mitogen-Activated Protein Kinases; MAP Kinase Signaling System; Methionine; Mutagenesis; Peptides; Phosphorylation; Protein Structure, Tertiary; Serine; Threonine; Trans-Activators; Transfection; Trypsin; Tyrosine; Viral Proteins | 2006 |
A novel conotoxin from Conus striatus, mu-SIIIA, selectively blocking rat tetrodotoxin-resistant sodium channels.
Topics: Amino Acid Sequence; Animals; Aspartic Acid; Base Sequence; Conotoxins; Conus Snail; Cysteine; Dose-Response Relationship, Drug; Glutamine; Hydroxyproline; Molecular Sequence Data; Nervous System; Peptide Fragments; Rats; Serine; Sodium Channel Blockers; Sodium Channels; Structure-Activity Relationship; Tetrodotoxin | 2006 |
Zinc and mercuric ions distinguish TRESK from the other two-pore-domain K+ channels.
Topics: Animals; Calcium Channel Blockers; Cations, Divalent; Chlorocebus aethiops; COS Cells; Cysteine; Drug Resistance; Humans; Mercury; Mibefradil; Mice; Mutation; Oocytes; Potassium Channel Blockers; Potassium Channels; Potassium Channels, Tandem Pore Domain; Serine; Xenopus laevis; Zinc | 2006 |
Cysteine 390 mutation of the TSH receptor modulates its ectodomain as an inverse agonist on the serpentine domain with decrease in basal constitutive activity.
Topics: Animals; Autoantibodies; Cell Line; Codon; Cyclic AMP; Cysteine; Hemagglutinins; Humans; Immunoglobulins, Thyroid-Stimulating; Mutation; Protein Structure, Tertiary; Receptors, FSH; Receptors, LH; Receptors, Thyrotropin; Serine; Signal Transduction; Silencer Elements, Transcriptional | 2005 |
EnP1 and EnP2, two proteins associated with the Encephalitozoon cuniculi endospore, the chitin-rich inner layer of the microsporidian spore wall.
Topics: Amino Acid Sequence; Antibodies, Fungal; Cell Wall; Chitin; Chromosomes, Fungal; Cysteine; DNA, Circular; DNA, Fungal; Electrophoresis, Polyacrylamide Gel; Encephalitozoon cuniculi; Fluorescent Antibody Technique, Indirect; Fungal Proteins; Glycosylation; Mass Spectrometry; Microscopy, Electron; Microscopy, Immunoelectron; Serine; Spores, Fungal | 2006 |
Interaction of OGG1 Ser326Cys polymorphism with cigarette smoking in head and neck squamous cell carcinoma.
Topics: Adult; Aged; Aged, 80 and over; Alcohol Drinking; Carcinoma, Squamous Cell; Cysteine; DNA Glycosylases; Female; Genetic Predisposition to Disease; Genotype; Head and Neck Neoplasms; Humans; Lymphatic Metastasis; Male; Middle Aged; Polymorphism, Genetic; Serine; Smoking | 2006 |
Spectroscopic characterizations of bridging cysteine ligand variants of an engineered Cu2(Scys)2 CuA azurin.
Topics: Azurin; Copper; Cysteine; Electron Spin Resonance Spectroscopy; Hydrogen Bonding; Ligands; Mass Spectrometry; Models, Molecular; Organometallic Compounds; Sensitivity and Specificity; Serine; Spectrophotometry, Ultraviolet | 2006 |
Do Craniosynostosis syndrome phenotypes with both FGFR2 and TWIST mutations have a worse clinical outcome?
Topics: Acrocephalosyndactylia; Adenine; Adolescent; Arginine; Child, Preschool; Craniofacial Dysostosis; Craniosynostoses; Cysteine; Cytosine; DNA Transposable Elements; Female; Follow-Up Studies; Guanine; Humans; Male; Mutation; Receptor, Fibroblast Growth Factor, Type 2; Sequence Deletion; Serine; Syndrome; Thymine; Treatment Outcome; Tryptophan; Twist-Related Protein 1 | 2006 |
Mechanistic pathways of formation of acrylamide from different amino acids.
Topics: Acrylamide; Acrylamides; Acrylates; Amino Acids; Ammonia; Asparagine; Aspartic Acid; beta-Alanine; Carbohydrates; Carnosine; Creatine; Cysteine; Fructose; Gas Chromatography-Mass Spectrometry; Hydrolysis; Mass Spectrometry; Models, Chemical; Pyruvic Acid; Serine; Time Factors | 2005 |
CpSufE activates the cysteine desulfurase CpNifS for chloroplastic Fe-S cluster formation.
Topics: Amino Acid Sequence; Amino Acid Substitution; Arabidopsis; Arabidopsis Proteins; Base Sequence; Carbon-Sulfur Lyases; Chloroplasts; Chromatography, Gel; Conserved Sequence; Cysteine; Enzyme Activation; Green Fluorescent Proteins; Histidine; Immunoblotting; Iron; Iron-Sulfur Proteins; Microscopy, Confocal; Molecular Sequence Data; Protein Structure, Tertiary; Recombinant Fusion Proteins; Sequence Homology, Amino Acid; Serine; Subcellular Fractions; Sulfur | 2006 |
The production, purification and crystallization of a soluble form of the nonclassical MHC HLA-G: the essential role of cobalt.
Topics: Amino Acid Substitution; Cations, Divalent; Cell Line, Tumor; Cobalt; Cysteine; Histocompatibility Antigens Class I; HLA Antigens; HLA-G Antigens; Humans; Protein Folding; Protein Structure, Tertiary; Recombinant Proteins; Serine; Solubility | 2006 |
[Blood serum and neutrophil amino acid concentrations during hemodialysis].
Topics: Adult; Arginine; Cysteine; Female; Humans; Male; Neutrophils; Renal Dialysis; Renal Insufficiency; Serine; Threonine | 2005 |
Cysteine-free glutathione-S-tranferase as a tool for thiol-specific labeling of proteins.
Topics: Amino Acid Substitution; Chromatography, Gel; Circular Dichroism; Cysteine; Escherichia coli; Glutathione; Glutathione Transferase; Plasmids; Point Mutation; Polymerase Chain Reaction; Proteins; Sequence Analysis, DNA; Serine; Spectrometry, Fluorescence; Sulfhydryl Compounds | 2006 |
Translated mutation in the Nurr1 gene as a cause for Parkinson's disease.
Topics: Aged; Amino Acid Substitution; Chromatography, High Pressure Liquid; Cysteine; DNA Mutational Analysis; DNA-Binding Proteins; Exons; Female; Genetic Carrier Screening; Humans; Introns; Male; Middle Aged; Nuclear Receptor Subfamily 4, Group A, Member 2; Parkinson Disease; Polymorphism, Genetic; Protein Biosynthesis; Sequence Analysis; Serine; Transcription Factors | 2006 |
Association of the OGG1 Ser326Cys polymorphism with tooth loss.
Topics: Aged; Aged, 80 and over; Cysteine; DNA Glycosylases; Female; Genetic Predisposition to Disease; Genotype; Humans; Male; Middle Aged; Polymorphism, Single Nucleotide; Regression Analysis; Serine; Tooth Loss | 2006 |
Site-directed PEGylation of human basic fibroblast growth factor.
Topics: Animals; BALB 3T3 Cells; Cysteine; Fibroblast Growth Factor 2; Humans; Mice; Mutagenesis, Site-Directed; Mutation; Polyethylene Glycols; Recombinant Proteins; Serine | 2006 |
Identification of essential amino acid residues in valine dehydrogenase from Streptomyces albus.
Topics: Amino Acid Oxidoreductases; Amino Acid Sequence; Amino Acid Substitution; Amino Acids, Essential; Cysteine; Kinetics; Models, Molecular; Mutagenesis, Site-Directed; Serine; Streptomyces; Valine Dehydrogenase (NADP+) | 2006 |
Substitution of serine for non-disulphide-bond-forming cysteine in grass carp (Ctenopharygodon idellus) growth hormone improves in vitro oxidative renaturation.
Topics: Amino Acid Substitution; Animals; Carps; Cysteine; Gene Expression Profiling; Growth Hormone; Guanidine; Hydrogen-Ion Concentration; In Vitro Techniques; Mutagenesis, Site-Directed; Oxidation-Reduction; Protein Folding; Protein Renaturation; Recombinant Proteins; Serine; Time Factors | 2006 |
Role of the kallikrein-kinin system in Ang-(1-7)-induced vasodilation in mesenteric arterioles of Wistar rats studied in vivo-in situ.
Topics: Animals; Aprotinin; Arterioles; Cysteine; Kallikrein-Kinin System; Kallikreins; Male; Peptide Hydrolases; Rats; Rats, Wistar; Serine; Vasodilation | 2006 |
Unique regulation of the active site of the serine esterase S-formylglutathione hydrolase.
Topics: Amino Acid Sequence; Animals; Arabidopsis; Arabidopsis Proteins; Binding Sites; Crystallography, X-Ray; Cysteine; Dimerization; Esterases; Models, Molecular; Molecular Sequence Data; Molecular Structure; Mutagenesis, Site-Directed; Protein Structure, Tertiary; Serine; Thiolester Hydrolases | 2006 |
Structure of the inactive variant C60S of Mycobacterium tuberculosis thiol peroxidase.
Topics: Amino Acid Substitution; Bacterial Proteins; Binding Sites; Crystallography, X-Ray; Cysteine; Models, Molecular; Mutagenesis, Site-Directed; Mycobacterium tuberculosis; Oxidation-Reduction; Peroxidases; Peroxiredoxins; Serine; Static Electricity | 2006 |
Engineered antibody-drug conjugates with defined sites and stoichiometries of drug attachment.
Topics: Animals; Antibodies, Monoclonal; Antineoplastic Agents; Base Sequence; Binding Sites; Cysteine; Disulfides; Immunoconjugates; Ki-1 Antigen; Ligands; Maximum Tolerated Dose; Mice; Oligopeptides; Protein Engineering; Serine; Solvents; Transplantation, Heterologous; Tumor Cells, Cultured | 2006 |
Contribution of cysteine residues in the extracellular domain of the F protein of human respiratory syncytial virus to its function.
Topics: Amino Acid Sequence; Cell Fusion; Cell Line; Cysteine; Humans; Models, Molecular; Molecular Sequence Data; Mutation; Respiratory Syncytial Virus, Human; Sequence Alignment; Serine; Structure-Activity Relationship; Transfection; Viral Fusion Proteins | 2006 |
Molecular dissection of the mycobacterial stringent response protein Rel.
Topics: Amino Acid Sequence; Circular Dichroism; Conserved Sequence; Cysteine; Databases, Protein; Guanosine Diphosphate; Hydrolysis; Ligases; Molecular Sequence Data; Mutation; Mycobacterium smegmatis; Protein Structure, Tertiary; RNA, Transfer; Sequence Deletion; Sequence Homology, Amino Acid; Serine | 2006 |
RcsF is an outer membrane lipoprotein involved in the RcsCDB phosphorelay signaling pathway in Escherichia coli.
Topics: Amino Acid Sequence; Bacterial Capsules; Bacterial Outer Membrane Proteins; Blotting, Western; Carrier Proteins; Cysteine; Escherichia coli; Escherichia coli Proteins; Molecular Sequence Data; Multienzyme Complexes; Peptidylprolyl Isomerase; Periplasm; Phosphoprotein Phosphatases; Phosphotransferases; Protein Kinases; Serine; Signal Transduction; Transcription Factors | 2006 |
A new type of bacterial sulfatase reveals a novel maturation pathway in prokaryotes.
Topics: Amino Acid Motifs; Amino Acid Sequence; Bacteria; Cloning, Molecular; Clostridium perfringens; Cysteine; Escherichia coli; Molecular Sequence Data; Oxygen; Plasmids; Sequence Homology, Amino Acid; Serine; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Sulfatases | 2006 |
Novel mutations of the PAX6 gene identified in Chinese patients with aniridia.
Topics: Aniridia; Asian People; Child; Cysteine; DNA Mutational Analysis; Eye Diseases; Eye Proteins; Female; Glutamine; Homeodomain Proteins; Humans; Infant; Male; Mutation; Paired Box Transcription Factors; PAX6 Transcription Factor; Phenotype; Repressor Proteins; Serine | 2006 |
Paraoxonase gene polymorphisms and sporadic ALS.
Topics: Adult; Aged; Amyotrophic Lateral Sclerosis; Arginine; Aryldialkylphosphatase; Chi-Square Distribution; Confidence Intervals; Cysteine; DNA Mutational Analysis; Female; Gene Frequency; Genotype; Glutamine; Humans; Logistic Models; Male; Middle Aged; Odds Ratio; Poland; Polymorphism, Single Nucleotide; Retrospective Studies; Serine | 2006 |
Association of a mutation in TRPV3 with defective hair growth in rodents.
Topics: Alopecia; Amino Acid Substitution; Animals; Cell Count; Cloning, Molecular; Cysteine; Dermatitis; Electrophysiology; Glycine; Histamine; Keratinocytes; Mast Cells; Mice; Mice, Nude; Mutation; Rats; Rats, Nude; Serine; Skin; TRPV Cation Channels | 2006 |
Studies of an active site mutant of the selenoprotein thioredoxin reductase: the Ser-Cys-Cys-Ser motif of the insect orthologue is not sufficient to replace the Cys-Sec dyad in the mammalian enzyme.
Topics: Amino Acid Motifs; Amino Acid Sequence; Animals; Base Sequence; Binding Sites; Cysteine; DNA Primers; Drosophila melanogaster; Electrophoresis, Polyacrylamide Gel; Molecular Sequence Data; Mutation; Sequence Homology, Amino Acid; Serine; Thioredoxin-Disulfide Reductase | 2006 |
Prospective study of FGFR3 mutations as a prognostic factor in nonmuscle invasive urothelial bladder carcinomas.
Topics: Adult; Aged; Aged, 80 and over; Alanine; Cysteine; Female; Glutamic Acid; Glycine; Humans; Leucine; Male; Middle Aged; Multivariate Analysis; Mutation; Phenylalanine; Polymerase Chain Reaction; Predictive Value of Tests; Prognosis; Proportional Hazards Models; Prospective Studies; Receptor, Fibroblast Growth Factor, Type 3; Sequence Analysis, DNA; Serine; Tyrosine; Urinary Bladder Neoplasms | 2006 |
Functional and structural characterization of a thiol peroxidase from Mycobacterium tuberculosis.
Topics: Amino Acid Sequence; Binding Sites; Crystallography, X-Ray; Cysteine; Dimerization; Molecular Sequence Data; Molecular Weight; Mutant Proteins; Mutation; Mycobacterium tuberculosis; NADP; Oxidation-Reduction; Peroxidases; Protein Structure, Quaternary; Protein Structure, Secondary; Serine; Solutions | 2006 |
Determination of d-serine and related neuroactive amino acids in human plasma by high-performance liquid chromatography with fluorimetric detection.
Topics: Amino Acids; Chromatography, High Pressure Liquid; Cysteine; Fluorometry; Glutamic Acid; Glutamine; Humans; Molecular Structure; o-Phthalaldehyde; Serine; Stereoisomerism | 2006 |
The location of an engineered inter-subunit disulfide bond in factor for inversion stimulation (FIS) affects the denaturation pathway and cooperativity.
Topics: Circular Dichroism; Crystallography, X-Ray; Cysteine; Disulfides; DNA; Factor For Inversion Stimulation Protein; Fluorescence; Guanidine; Hydrogen Bonding; Hydrogen-Ion Concentration; Models, Molecular; Mutation; Oxidation-Reduction; Protein Binding; Protein Denaturation; Protein Engineering; Protein Subunits; Serine; Structure-Activity Relationship; Urea; Valine | 2006 |
Specific cleavage of DJ-1 under an oxidative condition.
Topics: Blotting, Western; Cell Line, Tumor; Cysteine; Dose-Response Relationship, Drug; Gene Expression; Glycine; Humans; Hydrogen Peroxide; Intracellular Signaling Peptides and Proteins; Mass Spectrometry; Neuroblastoma; Oncogene Proteins; Oxidants; Oxidation-Reduction; Oxidative Stress; Proline; Protein Deglycase DJ-1; Serine | 2006 |
Juvenile bilateral lens dislocation and glaucoma associated with a novel mutation in the fibrillin 1 gene.
Topics: Adult; Aged; Amino Acid Substitution; Child; Child, Preschool; Corneal Diseases; Cysteine; Exons; Female; Fibrillin-1; Fibrillins; Genetic Linkage; Glaucoma; Humans; Lens Subluxation; Lod Score; Male; Microfilament Proteins; Middle Aged; Mutation, Missense; Pedigree; Serine; Syndrome | 2006 |
Exploring the role of the active site cysteine in human muscle creatine kinase.
Topics: Adenosine Diphosphate; Animals; Binding Sites; Computer Simulation; Creatine; Creatine Kinase, MM Form; Cysteine; Humans; Hydrogen-Ion Concentration; Kinetics; Models, Molecular; Mutant Proteins; Phosphorylation; Proline; Serine; Spectrophotometry, Ultraviolet; Structure-Activity Relationship; Torpedo | 2006 |
Influence of DNA repair gene polymorphisms of hOGG1, XRCC1, XRCC3, ERCC2 and the folate metabolism gene MTHFR on chromosomal aberration frequencies.
Topics: Adult; Chromosome Aberrations; Cohort Studies; Cysteine; DNA Glycosylases; DNA Repair; DNA-Binding Proteins; Folic Acid; Humans; Male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Polymorphism, Genetic; Serine; X-ray Repair Cross Complementing Protein 1; Xeroderma Pigmentosum Group D Protein | 2006 |
Hydrogen bonding pathways in human dihydroorotate dehydrogenase.
Topics: Carbon; Cysteine; Dihydroorotate Dehydrogenase; Escherichia coli; Humans; Hydrogen Bonding; Models, Chemical; Models, Molecular; Molecular Conformation; Oxidation-Reduction; Oxidoreductases Acting on CH-CH Group Donors; Protons; Serine; Solvents; Threonine | 2006 |
Interactions between the OGG1 Ser326Cys polymorphism and intake of fruit and vegetables in relation to lung cancer.
Topics: Cysteine; Diet; DNA Glycosylases; Female; Fruit; Genetic Predisposition to Disease; Humans; Lung Neoplasms; Male; Middle Aged; Polymorphism, Genetic; Prospective Studies; Serine; Smoking; Vegetables | 2006 |
Disrupted in schizophrenia 1 genotype and positive symptoms in schizophrenia.
Topics: Cysteine; Delusions; Genetic Carrier Screening; Genetic Predisposition to Disease; Genotype; Hallucinations; Haplotypes; Homozygote; Humans; Nerve Tissue Proteins; Polymorphism, Single Nucleotide; Psychiatric Status Rating Scales; Psychotic Disorders; Schizophrenia; Serine | 2007 |
Conversion of methionine to cysteine in Bacillus subtilis and its regulation.
Topics: Bacillus subtilis; Bacterial Proteins; Carbon-Oxygen Lyases; Cystathionine; Cystathionine beta-Synthase; Cysteine; Gene Expression Regulation, Bacterial; Genes, Bacterial; Homocysteine; Lyases; Methionine; Operon; Promoter Regions, Genetic; Serine; Substrate Specificity | 2007 |
Evaluation and improvement of the properties of the novel cystine-knot microprotein McoEeTI for oral administration.
Topics: Acrylic Resins; Administration, Oral; Amino Acid Sequence; Animals; Cell Membrane Permeability; Chitin; Chymotrypsin; Cyclotides; Cysteine; Cystine; Cystine Knot Motifs; Diffusion Chambers, Culture; Drug Carriers; Drug Stability; Intestinal Absorption; Molecular Sequence Data; Plant Proteins; Protein Conformation; Protein Engineering; Rats; Recombinant Fusion Proteins; Serine; Swine; Time Factors; Trypsin; Trypsin Inhibitor, Bowman-Birk Soybean | 2007 |
Biosynthesis of phosphoserine in the Methanococcales.
Topics: Archaeal Proteins; Aspartic Acid; Chromatography, Affinity; Cysteine; Electrophoresis, Polyacrylamide Gel; Escherichia coli; Genetic Complementation Test; Methanococcales; Mutation; Phosphoglycerate Dehydrogenase; Phosphoserine; Phylogeny; Pyruvates; Serine; Transaminases | 2007 |
Cysteine-179 of IkappaB kinase beta plays a critical role in enzyme activation by promoting phosphorylation of activation loop serines.
Topics: Adenosine Triphosphate; Amino Acid Substitution; Catalytic Domain; Cells, Cultured; Cysteine; Enzyme Activation; HeLa Cells; Humans; I-kappa B Kinase; MAP Kinase Kinase Kinases; Mutant Proteins; Phosphorylation; Protein Binding; Serine; Transfection | 2006 |
Identification of novel FZD4 mutations in Indian patients with familial exudative vitreoretinopathy.
Topics: Adolescent; Adult; Amino Acid Sequence; Arginine; Asian People; Cysteine; Exons; Exudates and Transudates; Eye Diseases; Fluorescein Angiography; Frizzled Receptors; Fundus Oculi; Humans; India; Male; Middle Aged; Molecular Sequence Data; Mutation; Pedigree; Phenylalanine; Proline; Receptors, G-Protein-Coupled; Retinal Diseases; Serine; Vitreous Body | 2006 |
FOXL2 mutations in Chinese patients with blepharophimosis-ptosis-epicanthus inversus syndrome.
Topics: Asian People; Blepharophimosis; Blepharoptosis; Cysteine; Cytosine; Eye Abnormalities; Eyelids; Forkhead Box Protein L2; Forkhead Transcription Factors; Guanine; Heterozygote; Histidine; Humans; Mutation; Mutation, Missense; Polymorphism, Single-Stranded Conformational; Serine; Syndrome; Thymine; Tyrosine | 2007 |
Nitric oxide S-nitrosylates serine racemase, mediating feedback inhibition of D-serine formation.
Topics: Adenosine Triphosphate; Amino Acid Sequence; Animals; Coenzymes; Cysteine; Enzyme Activation; Feedback, Physiological; Humans; Mice; Models, Molecular; Models, Neurological; Molecular Sequence Data; Nitric Oxide; Nitric Oxide Synthase Type I; Racemases and Epimerases; Receptors, N-Methyl-D-Aspartate; S-Nitrosoglutathione; Serine | 2007 |
First evidences for a third sulfatase maturation system in prokaryotes from E. coli aslB and ydeM deletion mutants.
Topics: Amino Acid Sequence; Arylsulfatases; Catalytic Domain; Cysteine; Escherichia coli K12; Escherichia coli Proteins; Gene Deletion; Genes, Bacterial; Models, Biological; Molecular Sequence Data; Operon; Protein Processing, Post-Translational; Recombinant Proteins; Sequence Homology, Amino Acid; Serine | 2007 |
Effect of surface histidine mutations and their number on the partitioning and refolding of recombinant human granulocyte-colony stimulating factor (Cys17Ser) in aqueous two-phase systems containing chelated metal ions.
Topics: Animals; Cell Line, Tumor; Chelating Agents; Cysteine; Electrophoresis, Polyacrylamide Gel; Granulocyte Colony-Stimulating Factor; Histidine; Metals; Mice; Mutation; Protein Folding; Recombinant Proteins; Serine; Water | 2007 |
hOGG1 Ser326Cys polymorphism and susceptibility to gallbladder cancer in a Chinese population.
Topics: Asian People; Case-Control Studies; China; Cysteine; DNA Glycosylases; Female; Gallbladder Neoplasms; Gene Frequency; Genetic Predisposition to Disease; Humans; Male; Middle Aged; Polymorphism, Genetic; Serine | 2007 |
Increased affinity for copper mediated by cysteine 111 in forms of mutant superoxide dismutase 1 linked to amyotrophic lateral sclerosis.
Topics: Amino Acid Substitution; Amyotrophic Lateral Sclerosis; Animals; Chlorocebus aethiops; Chromatography, Affinity; Copper; COS Cells; Cysteine; Enzyme Stability; Humans; Mice; Mice, Transgenic; Mutation; Serine; Spinal Cord; Superoxide Dismutase; Superoxide Dismutase-1; Transfection | 2007 |
Multiple fungal enzymes possess cysteine synthase activity in vitro.
Topics: Arginine; Aspergillus nidulans; Blotting, Northern; Carbon-Oxygen Lyases; Catalysis; Cysteine; Cysteine Synthase; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Fungal; Histidine; Models, Biological; Mutation; Phylogeny; Proline; Serine; Sulfates | 2007 |
Effects of serine-to-cysteine mutations on beta-lactamase folding.
Topics: Bacillus; beta-Lactamases; Computer Simulation; Cysteine; Models, Molecular; Molecular Conformation; Mutation; Protein Denaturation; Protein Folding; Protein Structure, Secondary; Protein Structure, Tertiary; Sensitivity and Specificity; Serine; Sulfhydryl Compounds; Thermodynamics | 2007 |
SPECT revealed cortical dysfunction in a patient who had genetically definite megalencephalic leukoencephalopathy with subcortical cysts.
Topics: Adult; Astrocytes; Central Nervous System Cysts; Cephalometry; Cerebellum; Cerebral Cortex; Chromosome Aberrations; Codon; Consanguinity; Cysteine; Dementia, Vascular; DNA Mutational Analysis; Genes, Recessive; Homozygote; Humans; Leucine; Magnetic Resonance Imaging; Male; Membrane Proteins; Neurologic Examination; Organotechnetium Compounds; Serine; Tomography, Emission-Computed, Single-Photon | 2007 |
Association of the hOGG1 Ser326Cys polymorphism with sporadic amyotrophic lateral sclerosis.
Topics: Age Factors; Aged; Amino Acid Sequence; Amino Acid Substitution; Amyotrophic Lateral Sclerosis; Cysteine; Disease Progression; DNA Glycosylases; DNA Mutational Analysis; Female; Gene Frequency; Genetic Markers; Genetic Predisposition to Disease; Genetic Testing; Genotype; Humans; Male; Middle Aged; Mutation; Phenotype; Polymorphism, Genetic; Serine; Sex Factors | 2007 |
Aspartate-444 is essential for productive substrate interactions in a neuronal glutamate transporter.
Topics: Alanine; Animals; Aspartic Acid; Binding Sites; Cysteine; Dicarboxylic Acid Transporters; Excitatory Amino Acid Transporter 3; Glutamic Acid; HeLa Cells; Humans; Microinjections; Mutation; Neurons; Oocytes; Protein Conformation; Protein Structure, Tertiary; Rabbits; Serine; Succinic Acid; Transfection; Xenopus laevis | 2007 |
Identification of Cys385 in the isolated kinase insertion domain of heme-regulated eIF2 alpha kinase (HRI) as the heme axial ligand by site-directed mutagenesis and spectral characterization.
Topics: Animals; Cysteine; eIF-2 Kinase; Electron Spin Resonance Spectroscopy; Gene Expression Regulation; Heme; Ligands; Mice; Mutagenesis, Insertional; Protein Binding; Protein Structure, Tertiary; Serine; Spectrophotometry, Ultraviolet; Spectrum Analysis, Raman | 2007 |
On the regioselectivity of thioether formation by lacticin 481 synthetase.
Topics: Bacteriocins; Cysteine; Enzymes; Peptides; Serine; Sulfides; Threonine | 2007 |
Crystallization and preliminary X-ray analysis of a decameric form of cytosolic thioredoxin peroxidase 1 (Tsa1), C47S mutant, from Saccharomyces cerevisiae.
Topics: Amino Acid Sequence; Crystallization; Crystallography, X-Ray; Cysteine; Cytosol; Molecular Sequence Data; Mutation; Peroxidases; Peroxiredoxins; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Serine | 2007 |
Ultrahigh-resolution study on Pyrococcus abyssi rubredoxin: II. Introduction of an O-H...Sgamma-Fe hydrogen bond increased the reduction potential by 65 mV.
Topics: Crystallization; Crystallography, X-Ray; Cysteine; Hydrogen Bonding; Iron; Mutation; Protein Conformation; Pyrococcus abyssi; Rubredoxins; Serine; Solutions | 2007 |
Identification of the cysteine residue exposed by the conformational change in pig heart succinyl-CoA:3-ketoacid coenzyme A transferase on binding coenzyme A.
Topics: Amino Acid Sequence; Amino Acid Substitution; Animals; Binding Sites; Coenzyme A; Coenzyme A-Transferases; Crystallography, X-Ray; Cysteine; Escherichia coli; Escherichia coli Proteins; Glutamic Acid; Models, Chemical; Models, Molecular; Myocardium; Protein Binding; Protein Conformation; Protein Structure, Tertiary; Sequence Homology, Amino Acid; Serine; Swine | 2007 |
Characterization of a family of novel cysteine- serine-rich nuclear proteins (CSRNP).
Topics: Amino Acid Sequence; Animals; Cells, Cultured; Cysteine; Humans; Interleukin-2; Mice; Mice, Transgenic; Nuclear Proteins; Sequence Alignment; Serine; Transfection | 2007 |
HTR2C (cys23ser) polymorphism influences early onset in bipolar patients in a large European multicenter association study.
Topics: Bipolar Disorder; Cysteine; Europe; Gene Frequency; Genotype; Humans; Polymorphism, Genetic; Psychiatric Status Rating Scales; Receptor, Serotonin, 5-HT2C; Serine | 2007 |
X-ray crystal structural analysis of the binding site in the ferric and oxyferrous forms of the recombinant heme dehaloperoxidase cloned from Amphitrite ornata.
Topics: Animals; Binding Sites; Crystallography, X-Ray; Cysteine; Escherichia coli; Heme; Hemoglobins; Hydrogen Bonding; Models, Chemical; Models, Molecular; Molecular Conformation; Peroxidases; Polychaeta; Protein Conformation; Recombinant Proteins; Serine | 2007 |
Compound heterozygosity of novel missense mutations (Ser45 --> Gly, Cys278 --> Arg) in the lipoprotein lipase gene in a newborn Korean infant.
Topics: Arginine; Cysteine; Female; Glycine; Heterozygote; Humans; Infant, Newborn; Infant, Small for Gestational Age; Korea; Lipoprotein Lipase; Male; Mutation, Missense; Pedigree; Serine | 2008 |
A Nurr1 point mutant, implicated in Parkinson's disease, uncouples ERK1/2-dependent regulation of tyrosine hydroxylase transcription.
Topics: Cell Line, Transformed; Cysteine; DNA-Binding Proteins; Dopamine Agonists; Drug Interactions; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Gene Expression Regulation; Humans; Mitogen-Activated Protein Kinase 3; Mutation; Neuroblastoma; Nuclear Receptor Subfamily 4, Group A, Member 2; Quinpirole; Serine; Transcription Factors; Transfection; Tyrosine 3-Monooxygenase | 2008 |
Chemical dissection of the APC Repeat 3 multistep phosphorylation by the concerted action of protein kinases CK1 and GSK3.
Topics: Adenomatous Polyposis Coli Protein; Amino Acid Sequence; Amino Acid Substitution; Arginine; beta Catenin; Binding Sites; Casein Kinase I; Cloning, Molecular; Cysteine; Escherichia coli; Glycogen Synthase Kinase 3; Holoenzymes; Humans; Isoenzymes; Models, Chemical; Molecular Sequence Data; Peptides; Phosphorylation; Protein Binding; Protein Subunits; Recombinant Proteins; Sequence Homology, Amino Acid; Serine; Transformation, Genetic | 2007 |
Hydrolysis of non-cognate aminoacyl-adenylates by a class II aminoacyl-tRNA synthetase lacking an editing domain.
Topics: Adenosine Monophosphate; Binding Sites; Cysteine; Escherichia coli Proteins; Hydrolysis; Protein Structure, Tertiary; RNA Editing; Saccharomyces cerevisiae Proteins; Serine; Serine-tRNA Ligase; Substrate Specificity; Threonine | 2007 |
Influence of pH and flanking serine on the redox potential of S-S and S-Se bridges of Cys-Cys and Cys-Sec peptides.
Topics: Cysteine; Disulfides; Hydrogen-Ion Concentration; Oxidation-Reduction; Peptides; Selenium; Selenocysteine; Serine | 2007 |
Cloning and characterization of two Lactobacillus casei genes encoding a cystathionine lyase.
Topics: Cloning, Molecular; Cystathionine; Cysteine; Enzyme Stability; Homoserine; Hydrogen Sulfide; Hydrogen-Ion Concentration; Keto Acids; Lacticaseibacillus casei; Lyases; Methionine; Molecular Sequence Data; Recombinant Proteins; Serine; Substrate Specificity; Sulfhydryl Compounds | 2008 |
OGG1 expression and OGG1 Ser326Cys polymorphism and risk of lung cancer in a prospective study.
Topics: Amino Acid Substitution; Case-Control Studies; Cohort Studies; Cysteine; DNA Glycosylases; DNA Repair; Female; Genetic Markers; Humans; Lung Neoplasms; Male; Middle Aged; Oxidative Stress; Polymorphism, Single Nucleotide; Prospective Studies; Risk Factors; RNA, Messenger; Serine; Smoking | 2008 |
A combined approach of mass spectrometry, molecular modeling, and site-directed mutagenesis highlights key structural features responsible for the thermostability of Sulfolobus solfataricus carboxypeptidase.
Topics: Alkylation; Amino Acid Sequence; Amino Acid Substitution; Asparagine; Aspartic Acid; Carboxypeptidases; Cysteine; Disulfides; Enzyme Activation; Enzyme Stability; Hot Temperature; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kinetics; Mass Spectrometry; Models, Chemical; Models, Molecular; Molecular Sequence Data; Molecular Weight; Mutagenesis, Site-Directed; Oxidation-Reduction; Pepsin A; Protein Engineering; Protein Structure, Secondary; Protein Subunits; Serine; Sulfolobus solfataricus; Thermodynamics; Trypsin | 2008 |
The crystal structure of N-acetyl-L-glutamate synthase from Neisseria gonorrhoeae provides insights into mechanisms of catalysis and regulation.
Topics: Acetyltransferases; Allosteric Site; Amino-Acid N-Acetyltransferase; Arginine; Catalysis; Crystallography, X-Ray; Cysteine; Leucine; Models, Biological; Molecular Conformation; Neisseria gonorrhoeae; Protein Binding; Protein Structure, Tertiary; Serine; Stereoisomerism | 2008 |
Functional and structural roles of conserved cysteine residues in the carboxyl-terminal domain of the follicle-stimulating hormone receptor in human embryonic kidney 293 cells.
Topics: Alanine; Amino Acid Sequence; Cell Line; Computer Simulation; Cyclic AMP; Cysteine; Humans; Kidney; Lipoylation; Molecular Sequence Data; Mutation; Receptors, FSH; Serine; Threonine | 2008 |
Second case of Beare-Stevenson syndrome with an FGFR2 Ser372Cys mutation.
Topics: Abnormalities, Multiple; Amino Acid Substitution; Base Sequence; Craniosynostoses; Cysteine; Humans; Infant; Male; Molecular Sequence Data; Point Mutation; Receptor, Fibroblast Growth Factor, Type 2; Serine; Skin Abnormalities; Skull; Syndrome | 2008 |
Nitric oxide-mediated modulation of calcium/calmodulin-dependent protein kinase II.
Topics: Animals; Benzylamines; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Cell Line, Tumor; Cysteine; Enzyme Activation; Hippocampus; Hydrazines; Indazoles; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase Type I; Protein Kinase Inhibitors; Rats; S-Nitroso-N-Acetylpenicillamine; Serine; Sulfonamides; Thyrotropin-Releasing Hormone | 2008 |
Singular efficacy of trimethylamine N-oxide to counter protein destabilization in ice.
Topics: Azurin; Betaine; Cysteine; Freeze Drying; Ice; Methylamines; Osmolar Concentration; Oxidants; Protein Denaturation; Protein Folding; Pseudomonas aeruginosa; Sarcosine; Serine; Solutions; Thermodynamics | 2008 |
Key residues of loop 3 in the interaction with the interface residue at position 14 in triosephosphate isomerase from Trypanosoma brucei.
Topics: Amino Acid Substitution; Animals; Circular Dichroism; Cysteine; Enzyme Stability; Hot Temperature; Kinetics; Mutation; Protein Structure, Tertiary; Serine; Solvents; Spectrometry, Fluorescence; Surface Properties; Triose-Phosphate Isomerase; Trypanosoma brucei brucei | 2008 |
Inhibiting wild-type and C299S mutant AKR1B10; a homologue of aldose reductase upregulated in cancers.
Topics: Aldehyde Reductase; Aldo-Keto Reductases; Antibiotics, Antineoplastic; Antineoplastic Agents; Benzothiazoles; Clofibric Acid; Cysteine; Daunorubicin; Dose-Response Relationship, Drug; Enzyme Inhibitors; Glyceraldehyde; Humans; Imidazolidines; Kinetics; Mutation; Neoplasms; Oxidation-Reduction; Phthalazines; Pyrimidines; Recombinant Proteins; Serine | 2008 |
HFE gene mutations in a population of Italian Parkinson's disease patients.
Topics: Adult; Aged; Aged, 80 and over; Aspartic Acid; Cysteine; DNA Mutational Analysis; Female; Gene Frequency; Genotype; Hemochromatosis Protein; Histidine; Histocompatibility Antigens Class I; Humans; Italy; Male; Membrane Proteins; Middle Aged; Mutation; Parkinson Disease; Serine | 2008 |
Family-based association testing strongly implicates DRD2 as a risk gene for schizophrenia in Han Chinese from Taiwan.
Topics: Asian People; Case-Control Studies; Cysteine; Family Health; Female; Gene Frequency; Genetic Predisposition to Disease; Genotype; Humans; Linkage Disequilibrium; Male; Polymorphism, Single Nucleotide; Receptors, Dopamine D2; Risk; Schizophrenia; Serine; Taiwan | 2009 |
Lrrk2 R1441C parkinsonism is clinically similar to sporadic Parkinson disease.
Topics: Adult; Aged; Aged, 80 and over; Amino Acid Substitution; Arginine; Cysteine; DNA Mutational Analysis; Female; Glycine; Haplotypes; Humans; Internationality; Leucine-Rich Repeat Serine-Threonine Protein Kinase-2; Male; Middle Aged; Parkinson Disease; Parkinsonian Disorders; Protein Serine-Threonine Kinases; Serine | 2008 |
Methylated DNA recognition during the reversal of epigenetic silencing is regulated by cysteine and serine residues in the Epstein-Barr virus lytic switch protein.
Topics: Base Sequence; Cell Line, Tumor; Cysteine; DNA Methylation; DNA-Binding Proteins; Epigenesis, Genetic; Gene Expression Regulation, Viral; Gene Silencing; Genome, Viral; Herpesvirus 4, Human; Humans; Molecular Sequence Data; Mutation, Missense; Response Elements; Serine; Trans-Activators; Viral Proteins | 2008 |
Mutagenesis of the active-site cysteine in the ubiquitin-specific protease contained in large tegument protein pUL36 of pseudorabies virus impairs viral replication in vitro and neuroinvasion in vivo.
Topics: Amino Acid Sequence; Amino Acid Substitution; Animals; Binding Sites; Cell Line; Cysteine; Endopeptidases; Herpesvirus 1, Suid; Immunohistochemistry; In Vitro Techniques; Kinetics; Mice; Mice, Inbred Strains; Molecular Sequence Data; Mutagenesis, Site-Directed; Neurons; Serine; Ubiquitin-Specific Proteases; Viral Structural Proteins; Virion; Virus Replication | 2008 |
Anaerobic sulfatase-maturating enzymes, first dual substrate radical S-adenosylmethionine enzymes.
Topics: Bacteroides; Binding Sites; Clostridium perfringens; Cysteine; Electron Spin Resonance Spectroscopy; Hydrogen; Iron-Sulfur Proteins; Oxidation-Reduction; Oxygen; Protein Processing, Post-Translational; S-Adenosylmethionine; Serine; Spectrum Analysis, Raman; Substrate Specificity; Sulfatases | 2008 |
Role of disulfide bonds in goose-type lysozyme.
Topics: Alanine; Animals; Biochemistry; Catalysis; Cysteine; Disulfides; Geese; Hydrogen-Ion Concentration; Models, Molecular; Muramidase; Mutation; Protein Conformation; Serine; Struthioniformes; Temperature | 2008 |
The roles of cys124 and ser239 in the functional properties of human betaIII tubulin.
Topics: Amino Acid Sequence; Colchicine; Cysteine; HeLa Cells; Humans; Kinetics; Microtubules; Molecular Sequence Data; Mutant Proteins; Protein Isoforms; Sequence Alignment; Serine; Tubulin | 2008 |
The BARD1 Cys557Ser polymorphism and breast cancer risk: an Australian case-control and family analysis.
Topics: Adult; Aged; Aged, 80 and over; Australia; Breast Neoplasms; Case-Control Studies; Cysteine; Family Health; Gene Expression Regulation, Neoplastic; Humans; Middle Aged; Polymorphism, Genetic; Risk; Serine; Tumor Suppressor Proteins; Ubiquitin-Protein Ligases | 2009 |
Stereoselective synthesis of triply isotope-labeled Ser, Cys, and Ala: amino acids for stereoarray isotope labeling technology.
Topics: Alanine; Amino Acids; Cysteine; Isotope Labeling; Magnetic Resonance Spectroscopy; Models, Molecular; Molecular Biology; Serine; Stereoisomerism | 2008 |
Influence of shifting positions of Ser, Thr, and Cys residues in prenisin on the efficiency of modification reactions and on the antimicrobial activities of the modified prepeptides.
Topics: Amino Acid Sequence; Anti-Bacterial Agents; Binding Sites; Cysteine; Lactococcus lactis; Molecular Sequence Data; Nisin; Peptides; Plasmids; Protein Precursors; Protein Sorting Signals; Serine; Threonine | 2008 |
Uncovering a latent ligation site for glycopeptide synthesis.
Topics: Amino Acid Substitution; Cysteine; Glycopeptides; Glycosylation; Peptide Fragments; Serine | 2008 |
A divergent approach to the preparation of cysteine and serine analogs.
Topics: Amino Acids; Animals; Biochemistry; Carbon; Catalysis; Cysteine; Esterases; Hydrolysis; Liver; Models, Chemical; Peptides; Serine; Stereoisomerism; Swine | 2008 |
ERK1/2-mediated phosphorylation of small hepatitis delta antigen at serine 177 enhances hepatitis delta virus antigenomic RNA replication.
Topics: Cell Line, Tumor; Cysteine; Hepatitis delta Antigens; Hepatitis Delta Virus; Humans; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Models, Biological; Mutation; Phosphorylation; RNA; RNA Polymerase II; Serine; Transfection; Virus Replication | 2008 |
Design of (Gd-DO3A)n-polydiamidopropanoyl-peptide nucleic acid-D(Cys-Ser-Lys-Cys) magnetic resonance contrast agents.
Topics: Anthracenes; Base Sequence; Chelating Agents; Computer Simulation; Cysteine; Gadolinium; Gadolinium DTPA; Lysine; Magnetic Resonance Imaging; Models, Molecular; Molecular Conformation; Oligonucleotides; Oligopeptides; Peptide Nucleic Acids; Serine; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization | 2008 |
Analysis of the interaction between the UL11 and UL16 tegument proteins of herpes simplex virus.
Topics: Amino Acid Motifs; Amino Acid Substitution; Animals; Binding Sites; Cell Line; Chlorocebus aethiops; Cloning, Molecular; Conserved Sequence; Cysteine; Ethylmaleimide; Gene Expression; Herpesvirus 1, Human; Humans; Mutagenesis, Site-Directed; Protein Binding; Protein Interaction Domains and Motifs; Protein Interaction Mapping; Recombinant Proteins; Sequence Deletion; Serine; Viral Structural Proteins | 2008 |
The significance of disulfide bonding in biological activity of HB-EGF, a mutagenesis approach.
Topics: Animals; Cell Line; Cell Nucleus; Cloning, Molecular; Cysteine; Disulfides; ErbB Receptors; Fibroblasts; Heparin-binding EGF-like Growth Factor; Humans; Intercellular Signaling Peptides and Proteins; Metallothionein; Mice; Mutagenesis, Site-Directed; Phosphorylation; Promoter Regions, Genetic; RNA, Messenger; Serine; Tyrosine | 2008 |
Mitochondrial serine acetyltransferase functions as a pacemaker of cysteine synthesis in plant cells.
Topics: Arabidopsis; Arabidopsis Proteins; Cloning, Molecular; Cysteine; Gene Expression Regulation, Plant; Genes, Plant; MicroRNAs; Mitochondria; Oligonucleotide Array Sequence Analysis; Phenotype; Plants, Genetically Modified; Regression Analysis; Reverse Transcriptase Polymerase Chain Reaction; RNA, Plant; Serine; Serine O-Acetyltransferase; Sulfates; Transformation, Genetic | 2008 |
Crystal structure of glutathione-dependent phospholipid peroxidase Hyr1 from the yeast Saccharomyces cerevisiae.
Topics: Catalytic Domain; Crystallography, X-Ray; Cysteine; Glutathione Peroxidase; Mutant Proteins; Phospholipids; Protein Structure, Secondary; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Serine | 2008 |
The Ser311Cys variation in the paraoxonase 2 gene increases the risk of type 2 diabetes in northern Chinese.
Topics: Amino Acid Substitution; Aryldialkylphosphatase; Asian People; Blood Pressure; Case-Control Studies; China; Cysteine; Diabetes Mellitus, Type 2; Female; Gene Frequency; Genetic Predisposition to Disease; Humans; Hypertension; Male; Middle Aged; Multivariate Analysis; Regression Analysis; Serine | 2008 |
A cysteine-rich metal-binding domain from rubella virus non-structural protein is essential for viral protease activity and virus replication.
Topics: Amino Acid Motifs; Binding Sites; Calcium; Cysteine; Endopeptidases; Models, Molecular; Mutagenesis, Site-Directed; Protein Binding; Protein Structure, Tertiary; Rubella virus; Serine; Viral Nonstructural Proteins; Virus Replication; Zinc | 2009 |
Effect of disrupted-in-schizophrenia-1 on pre-frontal cortical function.
Topics: Age Factors; Brain Mapping; Cysteine; Female; Functional Laterality; Genotype; Humans; Magnetic Resonance Imaging; Male; Nerve Tissue Proteins; Polymorphism, Single Nucleotide; Prefrontal Cortex; Serine; Verbal Learning | 2008 |
Genetic analysis for five LRRK2 mutations in a Sardinian parkinsonian population: importance of G2019S and R1441C mutations in sporadic Parkinson's disease patients.
Topics: Adult; Age Factors; Aged; Aged, 80 and over; Arginine; Cysteine; DNA Mutational Analysis; Female; Gene Frequency; Genetic Predisposition to Disease; Genetic Testing; Genotype; Glycine; Humans; Italy; Leucine-Rich Repeat Serine-Threonine Protein Kinase-2; Male; Middle Aged; Mutation; Parkinson Disease; Population Groups; Protein Serine-Threonine Kinases; Serine; Tomography, Emission-Computed, Single-Photon | 2009 |
Molecular dissection of the mechanisms of substrate recognition and F-actin-mediated activation of cofilin-phosphatase Slingshot-1.
Topics: Actins; Catalysis; Cofilin 1; Cysteine; Dose-Response Relationship, Drug; Gene Expression Regulation; Humans; Microfilament Proteins; Phosphoprotein Phosphatases; Phosphoric Monoester Hydrolases; Protein Binding; Protein Structure, Tertiary; Pseudopodia; Serine; Substrate Specificity | 2008 |
Identification of new, well-populated amino-acid sidechain rotamers involving hydroxyl-hydrogen atoms and sulfhydryl-hydrogen atoms.
Topics: Amino Acids; Crystallography, X-Ray; Cysteine; Hydrogen; Hydrogen Bonding; Hydroxyl Radical; Protein Conformation; Protein Structure, Secondary; Serine; Sulfhydryl Compounds; Threonine; Tyrosine | 2008 |
O-phospho-L-serine and the thiocarboxylated sulfur carrier protein CysO-COSH are substrates for CysM, a cysteine synthase from Mycobacterium tuberculosis.
Topics: Carrier Proteins; Cysteine; Cysteine Synthase; Kinetics; Mycobacterium tuberculosis; Oxidative Stress; Phosphoserine; Serine; Spectrophotometry; Substrate Specificity | 2008 |
Kinetic partitioning between aggregation and vesicle permeabilization by modified ADan.
Topics: Adaptor Proteins, Signal Transducing; Amino Acid Sequence; Amyloid; Circular Dichroism; Cysteine; Dementia; Humans; Hydrogen-Ion Concentration; Liposomes; Membrane Glycoproteins; Membrane Proteins; Molecular Sequence Data; Osmolar Concentration; Permeability; Protein Binding; Protein Structure, Quaternary; Protein Structure, Secondary; Serine; Spectroscopy, Fourier Transform Infrared; Time Factors | 2009 |
Solution structure and backbone dynamics of the cysteine 103 to serine mutant of the N-terminal domain of DsbD from Neisseria meningitidis.
Topics: Catalytic Domain; Cysteine; Magnetic Resonance Spectroscopy; Models, Molecular; Mutant Proteins; Mutation; Neisseria meningitidis; Oxidoreductases; Protein Structure, Tertiary; Serine; Solutions | 2008 |
The sulfur atoms of the substrate CoA and the catalytic cysteine are required for a productive mode of substrate binding in bacterial biosynthetic thiolase, a thioester-dependent enzyme.
Topics: Acetyl-CoA C-Acyltransferase; Bacterial Proteins; Binding Sites; Coenzyme A; Cysteine; Kinetics; Ligands; Models, Molecular; Mutagenesis, Site-Directed; Pantothenic Acid; Serine; Substrate Specificity; Sulfhydryl Compounds; Sulfur | 2008 |
NMDA receptor activation by HIV-Tat protein is clade dependent.
Topics: Amino Acid Motifs; Animals; Antibodies; Cells, Cultured; Cysteine; Dizocilpine Maleate; Dose-Response Relationship, Drug; Embryo, Mammalian; Excitatory Amino Acid Antagonists; Gene Expression Regulation; Hippocampus; Humans; Immunoprecipitation; Models, Molecular; Mutagenesis, Site-Directed; Neurons; Nitric Oxide Donors; Protein Binding; Rats; Receptors, N-Methyl-D-Aspartate; S-Nitrosoglutathione; Serine; tat Gene Products, Human Immunodeficiency Virus; Transfection; Valine | 2008 |
Association of the SerCys DISC1 polymorphism with human hippocampal formation gray matter and function during memory encoding.
Topics: Adult; Alleles; Amino Acid Sequence; Amino Acid Substitution; Cysteine; DNA Mutational Analysis; Female; Genetic Predisposition to Disease; Genetic Variation; Genotype; Hippocampus; Humans; Magnetic Resonance Imaging; Male; Memory; Memory Disorders; Nerve Tissue Proteins; Neural Pathways; Polymorphism, Genetic; Prefrontal Cortex; Schizophrenia; Serine; Young Adult | 2008 |
High-casein diet suppresses guanidinoacetic acid-induced hyperhomocysteinemia and potentiates the hypohomocysteinemic effect of serine in rats.
Topics: Animals; Caseins; Cysteine; Diet; Glycine; Homocysteine; Hyperhomocysteinemia; Male; Methionine; Rats; Rats, Wistar; Serine | 2008 |
Human polycomb 2 protein is a SUMO E3 ligase and alleviates substrate-induced inhibition of cystathionine beta-synthase sumoylation.
Topics: Cystathionine beta-Synthase; Cysteine; Enzyme Activation; Homocysteine; Humans; Ligases; Models, Molecular; Polycomb-Group Proteins; Protein Processing, Post-Translational; Repressor Proteins; S-Adenosylmethionine; Serine; SUMO-1 Protein; Ubiquitin-Protein Ligases | 2008 |
Structure-function roles of four cysteine residues in the human arsenic (+3 oxidation state) methyltransferase (hAS3MT) by site-directed mutagenesis.
Topics: Arsenic; Circular Dichroism; Cysteine; Dose-Response Relationship, Drug; Humans; Kinetics; Methylation; Methyltransferases; Mutagenesis, Site-Directed; Protein Structure, Secondary; Selenium; Serine; Spectroscopy, Fourier Transform Infrared; Structure-Activity Relationship | 2009 |
Engineering antibody fragments to fold in the absence of disulfide bonds.
Topics: Amino Acid Sequence; Antigens, Bacterial; Bacterial Toxins; Cysteine; Directed Molecular Evolution; Disulfides; Enzyme-Linked Immunosorbent Assay; Escherichia coli; Escherichia coli Proteins; Flow Cytometry; Gene Library; Immunoglobulin Variable Region; Molecular Sequence Data; Mutation; Oxidation-Reduction; Protein Conformation; Protein Disulfide-Isomerases; Protein Engineering; Protein Folding; Sequence Alignment; Serine | 2009 |
Transmembrane domain 8 of the {gamma}-aminobutyric acid transporter GAT-1 lines a cytoplasmic accessibility pathway into its binding pocket.
Topics: Aspartic Acid; Cysteine; Cytoplasm; GABA Plasma Membrane Transport Proteins; gamma-Aminobutyric Acid; HeLa Cells; Humans; Models, Biological; Mutation; Protein Binding; Protein Structure, Secondary; Protein Structure, Tertiary; Protein Transport; Serine | 2009 |
Efficient substitution reaction from cysteine to the serine residue of glycosylated polypeptide: repetitive peptide segment ligation strategy and the synthesis of glycosylated tetracontapeptide having acid labile sialyl-T(N) antigens.
Topics: Antigens, Tumor-Associated, Carbohydrate; Cysteine; Glycopeptides; Serine | 2009 |
Interchain disulfide bonding in human IgG2 antibodies probed by site-directed mutagenesis.
Topics: Amino Acid Substitution; Antibodies, Monoclonal; Cysteine; Disulfides; Electrophoresis, Polyacrylamide Gel; Humans; Immunoglobulin G; Immunoglobulin kappa-Chains; Mutagenesis, Site-Directed; Peptide Fragments; Peptide Mapping; Recombinant Proteins; Serine; Spectrometry, Mass, Electrospray Ionization | 2009 |
Formation of two intramolecular disulfide bonds is necessary for ApoA-I-dependent cholesterol efflux mediated by ABCA1.
Topics: Amino Acid Sequence; Animals; Apolipoprotein A-I; ATP Binding Cassette Transporter 1; ATP-Binding Cassette Transporters; Cell Membrane; Cholesterol; Cysteine; Disulfides; Humans; Molecular Sequence Data; Mutation; Protein Binding; Rats; Sequence Homology, Amino Acid; Serine; Trypsin | 2009 |
Gas-phase IR spectroscopy of deprotonated amino acids.
Topics: Amino Acids; Anions; Aspartic Acid; Cysteine; Gases; Glutamic Acid; Phenylalanine; Protons; Serine; Spectrophotometry; Spectrophotometry, Infrared; Tyrosine | 2009 |
Two pathways for cysteine biosynthesis in Leishmania major.
Topics: Amino Acid Sequence; Animals; Biological Transport; Biosynthetic Pathways; Blotting, Western; Catalysis; Cystathionine beta-Synthase; Cystathionine gamma-Lyase; Cysteine; Cysteine Synthase; Electrophoresis, Polyacrylamide Gel; Glutathione; Kinetics; Leishmania major; Methionine; Molecular Sequence Data; Protozoan Proteins; Sequence Homology, Amino Acid; Serine; Serine O-Acetyltransferase; Spermidine; Substrate Specificity; Sulfides; Sulfur Radioisotopes | 2009 |
Influence of key residues on the heterologous extracellular production of fungal ribonuclease U2 in the yeast Pichia pastoris.
Topics: Blotting, Western; Cysteine; Electrophoresis, Polyacrylamide Gel; Endoribonucleases; Histidine; Models, Molecular; Pichia; Protein Folding; Serine; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Temperature; Ustilago | 2009 |
The Disrupted-in-Schizophrenia-1 Ser704Cys polymorphism and brain morphology in schizophrenia.
Topics: Adult; Brain; Cognition Disorders; Cysteine; Female; Frontal Lobe; Gene Frequency; Genetic Predisposition to Disease; Genetic Variation; Genotype; Homozygote; Humans; Magnetic Resonance Imaging; Male; Nerve Tissue Proteins; Neuropsychological Tests; Polymorphism, Genetic; Schizophrenia; Schizophrenic Psychology; Serine | 2009 |
Tailoring a low-molecular weight protein tyrosine phosphatase into an efficient reporting protein.
Topics: Amino Acid Sequence; Cysteine; Humans; Molecular Sequence Data; Molecular Weight; Protein Conformation; Protein Engineering; Protein Tyrosine Phosphatases; Recombinant Fusion Proteins; Sequence Deletion; Serine; Solubility | 2009 |
Hepatic cystathionine beta-synthase activity does not increase in response to methionine supplementation in rats fed a low casein diet: association with plasma homocysteine concentrations.
Topics: Animals; Betaine-Homocysteine S-Methyltransferase; Caseins; Cystathionine beta-Synthase; Cysteine; Dietary Proteins; Dietary Supplements; Dose-Response Relationship, Drug; Energy Intake; Glycine; Homocysteine; Liver; Male; Methionine; Organ Size; Rats; Rats, Wistar; RNA, Messenger; S-Adenosylhomocysteine; S-Adenosylmethionine; Serine; Weight Gain | 2009 |
Association of the Ser326Cys polymorphism in the OGG1 gene with type 2 DM.
Topics: Aged; Amino Acid Substitution; Asian People; Cysteine; Diabetes Mellitus, Type 2; DNA Glycosylases; Female; Genetic Predisposition to Disease; Humans; Insulin; Insulin Secretion; Male; Middle Aged; Polymorphism, Genetic; Serine | 2009 |
Enantiospecific adsorption of amino acids on hydroxylated quartz (0001).
Topics: Adsorption; Alanine; Amino Acids; Cysteine; Glycine; Hydrogen Bonding; Hydroxylation; Models, Molecular; Molecular Conformation; Quantum Theory; Quartz; Serine; Stereoisomerism | 2009 |
A De Novo mutation of STK11 gene in a Chinese patient with Peutz-Jeghers syndrome.
Topics: Adult; Alleles; Amino Acid Substitution; AMP-Activated Protein Kinase Kinases; Biopsy; China; Codon; Cysteine; DNA Mutational Analysis; Exons; Female; Germ-Line Mutation; Humans; Intestinal Mucosa; Peutz-Jeghers Syndrome; Point Mutation; Protein Serine-Threonine Kinases; Serine | 2010 |
Relative contributions of cystathionine beta-synthase and gamma-cystathionase to H2S biogenesis via alternative trans-sulfuration reactions.
Topics: Alanine; Chromatography, High Pressure Liquid; Computer Simulation; Cystathionine beta-Synthase; Cystathionine gamma-Lyase; Cysteine; Humans; Hydrogen Sulfide; Kinetics; Mass Spectrometry; Models, Biological; Models, Chemical; Molecular Conformation; Serine; Sulfides; Sulfur | 2009 |
Using expressed protein ligation to probe the substrate specificity of lantibiotic synthetases.
Topics: Amino Acids; Analytic Sample Preparation Methods; Anti-Bacterial Agents; Bacterial Proteins; Bacteriocins; Cyclization; Cysteine; Dehydration; Gene Expression; Hydro-Lyases; Inteins; Ligases; Molecular Structure; Peptides; Protein Processing, Post-Translational; Recombinant Fusion Proteins; Serine; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Substrate Specificity; Threonine | 2009 |
Cysteine modification of a specific repressor protein controls the translational status of nucleus-encoded LHCII mRNAs in Chlamydomonas.
Topics: Algal Proteins; Amino Acid Substitution; Animals; Cell Nucleus; Chlamydomonas reinhardtii; Cysteine; Down-Regulation; Light; Mutation; Oxidative Stress; Phenotype; Photosystem II Protein Complex; Phototrophic Processes; Protein Binding; Protein Biosynthesis; Protein Stability; Protein Structure, Tertiary; Repressor Proteins; RNA, Algal; RNA, Messenger; Serine; Structure-Activity Relationship | 2009 |
Frequency of the S65C mutation in the hemochromatosis gene in Brazil.
Topics: Adult; Aged; Amino Acid Substitution; Brazil; Cysteine; Female; Gene Frequency; Hemochromatosis; Hemochromatosis Protein; Heterozygote; Histocompatibility Antigens Class I; Humans; Male; Membrane Proteins; Middle Aged; Mutation; Serine; Sex Characteristics | 2009 |
Mutational study of the role of N-terminal amino acid residues in tetrachlorohydroquinone reductive dehalogenase from Sphingomonas sp. UG30.
Topics: Amino Acid Sequence; Cysteine; DNA Mutational Analysis; Enzyme Stability; Glutathione; Hydrolases; Molecular Sequence Data; Oxidation-Reduction; Protein Binding; Protein Structure, Tertiary; Sequence Alignment; Serine; Sphingomonas; Temperature | 2009 |
Influence of nickel stress on growth and some important physiological/biochemical attributes in some diverse canola (Brassica napus L.) cultivars.
Topics: Brassica napus; Cysteine; Drug Resistance; Histidine; Nickel; Osmosis; Plant Leaves; Plant Shoots; Serine; Water | 2009 |
Detection of covalent and noncovalent intermediates in the polymerization reaction catalyzed by a C149S class III polyhydroxybutyrate synthase.
Topics: Acyl Coenzyme A; Acylation; Acyltransferases; Amino Acid Substitution; Catalysis; Catalytic Domain; Chromatiaceae; Cysteine; Polymers; Recombinant Proteins; Serine | 2009 |
Identification of an iron-sulfur cluster that modulates the enzymatic activity in NarE, a Neisseria meningitidis ADP-ribosyltransferase.
Topics: Adenosine Diphosphate Ribose; ADP Ribose Transferases; Bacterial Proteins; Blotting, Western; Catalysis; Cysteine; Electron Spin Resonance Spectroscopy; Electrophoresis, Polyacrylamide Gel; Enzyme Assays; Iron; Iron-Sulfur Proteins; Mutation; Neisseria meningitidis; Niacinamide; Recombinant Proteins; Serine; Spectrophotometry; Sulfur | 2009 |
Chiral transmission between amino acids: chirally selective amino acid substitution in the serine octamer as a possible step in homochirogenesis.
Topics: Amino Acids; Chemistry, Organic; Cysteine; Dimerization; Models, Chemical; Models, Molecular; Molecular Conformation; Serine; Spectrometry, Mass, Electrospray Ionization; Stereoisomerism | 2002 |
Two alleles of NF-kappaB in the sea anemone Nematostella vectensis are widely dispersed in nature and encode proteins with distinct activities.
Topics: Alleles; Animals; Cysteine; Dimerization; DNA; Haplotypes; Models, Genetic; NF-kappa B; Phylogeny; Polymorphism, Genetic; Protein Binding; Protein Structure, Tertiary; Sea Anemones; Serine; Transcription Factor RelA | 2009 |
Diverse vasopressin V2 receptor functionality underlying partial congenital nephrogenic diabetes insipidus.
Topics: Arginine; Blotting, Western; Cell Line; Chromosomes, Human, X; Cysteine; Diabetes Insipidus, Nephrogenic; DNA, Complementary; Genetic Linkage; Genetic Variation; Humans; Kidney; Microscopy, Confocal; Phenotype; Protein Biosynthesis; Receptors, Vasopressin; Serine; Tissue Distribution; Transcription, Genetic; Transfection | 2009 |
hOGG1 Ser326Cys polymorphism and risk of lung cancer by histological type.
Topics: Adenocarcinoma; Adult; Aged; Carcinoma, Small Cell; Carcinoma, Squamous Cell; Case-Control Studies; Cysteine; DNA Glycosylases; Female; Gene Frequency; Genetic Predisposition to Disease; Genotype; Humans; Lung Neoplasms; Male; Meta-Analysis as Topic; Middle Aged; Multivariate Analysis; Mutation, Missense; Odds Ratio; Polymorphism, Single Nucleotide; Risk Factors; Serine; Smoking | 2009 |
Cysteine mutagenesis reveals transmembrane residues associated with charge translocation in prestin.
Topics: Animals; Anion Transport Proteins; Cysteine; Disulfides; Electrophysiology; Gerbillinae; Green Fluorescent Proteins; Humans; Microscopy, Confocal; Mutagenesis; Mutation; Protein Structure, Secondary; Protein Transport; Serine; Sulfate Transporters; Valine | 2010 |
Characterization of two isotypes of l-threonine dehydratase from Entamoeba histolytica.
Topics: Adenosine Monophosphate; Allosteric Regulation; Amino Acid Sequence; Ammonia; Animals; Carboxylic Acids; Cysteine; Cytidine Monophosphate; Entamoeba histolytica; Enzyme Inhibitors; Gene Expression Regulation, Enzymologic; Humans; Isoelectric Point; Isoenzymes; Kinetics; Molecular Sequence Data; Molecular Weight; Protozoan Proteins; Pyridoxal; Sequence Homology, Amino Acid; Serine; Substrate Specificity; Threonine; Threonine Dehydratase | 2010 |
Overexpression of serine acetlytransferase produced large increases in O-acetylserine and free cysteine in developing seeds of a grain legume.
Topics: Arabidopsis; Crosses, Genetic; Cysteine; Cysteine Synthase; Gene Expression Regulation, Plant; Genotype; Lupinus; Metabolic Networks and Pathways; Methionine; Plants, Genetically Modified; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Seed Storage Proteins; Seeds; Serine; Serine O-Acetyltransferase; Sulfur | 2010 |
Solution structure of the IIAChitobiose-IIBChitobiose complex of the N,N'-diacetylchitobiose branch of the Escherichia coli phosphotransferase system.
Topics: Amino Acid Substitution; Binding Sites; Catalytic Domain; Cysteine; Disaccharides; Disulfides; Escherichia coli; Escherichia coli Proteins; Magnetic Resonance Spectroscopy; Models, Molecular; Mutation; Phosphoenolpyruvate Sugar Phosphotransferase System; Phosphorylation; Protein Binding; Protein Conformation; Protein Structure, Secondary; Protein Structure, Tertiary; Serine; Solutions | 2010 |
Strategies and limitations in dendrimeric immunogen synthesis. The influenza virus M2e epitope as a case study.
Topics: Amino Acid Sequence; Aminocaproic Acid; Animals; Antibodies, Monoclonal; Chromatography, High Pressure Liquid; Cysteine; Dendrimers; Enzyme-Linked Immunosorbent Assay; Epitopes; Molecular Sequence Data; Serine; Solutions; Sulfides; Vaccines, Synthetic; Viral Matrix Proteins | 2010 |
Protein crystallography reveals a role for the FS0 cluster of Escherichia coli nitrate reductase A (NarGHI) in enzyme maturation.
Topics: Catalysis; Cell Membrane; Crystallography, X-Ray; Cysteine; Electron Spin Resonance Spectroscopy; Electron Transport; Escherichia coli; Iron-Sulfur Proteins; Molybdenum; Mutagenesis, Site-Directed; Mutation; Nitrate Reductases; Oxygen; Serine | 2010 |
Comorbidity between bipolar disorder and alcohol use disorder: association of dopamine and serotonin gene polymorphisms.
Topics: Adult; Alcohol-Related Disorders; Bipolar Disorder; Chi-Square Distribution; Comorbidity; Cysteine; Databases, Genetic; Female; Gene Frequency; Genetic Predisposition to Disease; Humans; Male; Middle Aged; Neurotransmitter Transport Proteins; Polymorphism, Single Nucleotide; Psychiatric Status Rating Scales; Receptors, Dopamine; Receptors, Serotonin; Serine; Severity of Illness Index; Sex Factors | 2010 |
Over-expression, purification and characterization of an Asc-1 homologue from Gloeobacter violaceus.
Topics: Alanine; Biological Transport; Cysteine; Humans; Membrane Transport Proteins; Protein Structure, Secondary; Serine | 2010 |
N-terminal acetylation of cellular proteins creates specific degradation signals.
Topics: Acetylation; Alanine; Amino Acid Sequence; Cysteine; Half-Life; Methionine; Protein Stability; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Serine; Substrate Specificity; Ubiquitin-Protein Ligases; Ubiquitination; Valine | 2010 |
Structural basis for inverting the enantioselectivity of arylmalonate decarboxylase revealed by the structural analysis of the Gly74Cys/Cys188Ser mutant in the liganded form.
Topics: Amino Acid Substitution; Bordetella bronchiseptica; Carboxy-Lyases; Catalytic Domain; Crystallization; Crystallography, X-Ray; Cysteine; Glycine; Ligands; Protein Binding; Protein Conformation; Protons; Serine; Stereoisomerism | 2010 |
A novel mutation in the predicted TMIII domain of the PSEN2 gene in an Italian pedigree with atypical Alzheimer's disease.
Topics: Aged; Alzheimer Disease; Cognition Disorders; Cysteine; DNA Mutational Analysis; Female; Humans; Italy; Male; Middle Aged; Mutation; Neuropsychological Tests; Pedigree; Presenilin-2; Protein Structure, Tertiary; Serine | 2010 |
Cysteine as a modulator residue in the active site of xenobiotic reductase A: a structural, thermodynamic and kinetic study.
Topics: Alanine; Amino Acid Sequence; Amino Acid Substitution; Binding Sites; Coumarins; Cysteine; Kinetics; Molecular Sequence Data; Mutagenesis, Site-Directed; NAD; NADP; Oxidation-Reduction; Oxidoreductases; Protein Conformation; Pseudomonas putida; Serine; Substrate Specificity; Thermodynamics; Xenobiotics | 2010 |
Isotope fractionation of mercury during its photochemical reduction by low-molecular-weight organic compounds.
Topics: Chemical Fractionation; Cysteine; Glutathione; Kinetics; Mercury; Mercury Isotopes; Molecular Weight; Organic Chemicals; Oxidation-Reduction; Photochemical Processes; Serine; Solubility | 2010 |
Anaerobic sulfatase-maturating enzyme--a mechanistic link with glycyl radical-activating enzymes?
Topics: Alanine; Anaerobiosis; Binding Sites; Catalysis; Cysteine; Electron Spin Resonance Spectroscopy; Eukaryota; Glycine; Iron-Sulfur Proteins; Oxidation-Reduction; S-Adenosylmethionine; Serine; Substrate Specificity; Sulfatases | 2010 |
A functional polymorphism (Ser326Cys) of the human 8-oxoguanine DNA glycosylase (hOGG1) gene and schizophrenia.
Topics: Adult; Cysteine; DNA Glycosylases; Female; Gene Frequency; Genome-Wide Association Study; Genotype; Humans; Male; Middle Aged; Polymorphism, Single Nucleotide; Schizophrenia; Serine | 2010 |
Spectroscopic and computational investigation of three Cys-to-Ser mutants of nickel superoxide dismutase: insight into the roles played by the Cys2 and Cys6 active-site residues.
Topics: Catalytic Domain; Circular Dichroism; Computer Simulation; Cysteine; Ligands; Models, Biological; Models, Molecular; Mutation; Nickel; Serine; Superoxide Dismutase | 2010 |
The DISC1 Ser704Cys substitution affects centrosomal localization of its binding partner PCM1 in glia in human brain.
Topics: Adult; Amino Acid Substitution; Autoantigens; Brain; Cell Cycle Proteins; Centrosome; Cysteine; Female; Humans; Male; Middle Aged; Nerve Tissue Proteins; Neuroglia; Schizophrenia; Serine | 2010 |
Impact of sulfur starvation on cysteine biosynthesis in T-DNA mutants deficient for compartment-specific serine-acetyltransferase.
Topics: Anion Transport Proteins; Arabidopsis; Arabidopsis Proteins; Biological Transport; Carbon-Oxygen Lyases; Chloroplasts; Cysteine; Cysteine Synthase; Cytosol; DNA, Bacterial; Gene Expression Regulation, Plant; Gene Knockout Techniques; Plants, Genetically Modified; Plasmids; Plastids; Polymerase Chain Reaction; RNA, Plant; Seedlings; Serine; Serine O-Acetyltransferase; Sulfates; Sulfhydryl Compounds; Sulfur | 2010 |
A Cys/Ser mutation of NDPK-A stabilizes its oligomerization state and enhances its activity.
Topics: Amino Acid Sequence; Amino Acid Substitution; Cysteine; Deoxyribonucleases; Disulfides; Mutagenesis, Site-Directed; NM23 Nucleoside Diphosphate Kinases; Protein Multimerization; Serine | 2010 |
Influence of amino acids cysteine and serine on aggregation kinetics of zinc and mercury sulfide colloids.
Topics: Adsorption; Carboxylic Acids; Colloids; Cysteine; Environmental Pollutants; Hazardous Substances; Mercury Compounds; Serine; Sulfides; Zinc Compounds | 2010 |
Manipulation of thiocillin variants by prepeptide gene replacement: structure, conformation, and activity of heterocycle substitution mutants.
Topics: Alanine; Amino Acid Sequence; Amino Acid Substitution; Anti-Bacterial Agents; Bacillus cereus; Cysteine; Gene Knockout Techniques; Molecular Sequence Data; Multigene Family; Mutation; Nuclear Magnetic Resonance, Biomolecular; Peptides; Protein Conformation; Serine | 2010 |
Recessive multiple epiphyseal dysplasia (rMED) with homozygosity for C653S mutation in the DTDST gene--phenotype, molecular diagnosis and surgical treatment of habitual dislocation of multilayered patella: case report.
Topics: Adult; Amino Acid Substitution; Anion Transport Proteins; Cysteine; Genes, Recessive; Genetic Predisposition to Disease; Genotype; Homozygote; Humans; Knee Dislocation; Male; Mutation; Orthopedic Procedures; Osteochondrodysplasias; Patella; Phenotype; Serine; Sulfate Transporters; Treatment Outcome | 2010 |
Enantiospecific adsorption of amino acids on hydroxylated quartz (10 1 0).
Topics: Adsorption; Amino Acids; Asparagine; Aspartic Acid; Cysteine; Quartz; Serine; Stereoisomerism; Thermodynamics | 2010 |
Cysteinyl-glycine in the control of glutathione homeostasis in bovine lenses.
Topics: Animals; Borates; Cattle; Cysteine; Dipeptides; gamma-Glutamyltransferase; Glutathione; Homeostasis; Lens, Crystalline; Osmolar Concentration; Serine; Tissue Culture Techniques; Tissue Distribution; Up-Regulation | 2010 |
Dimeric crystal structure of rabbit L-gulonate 3-dehydrogenase/lambda-crystallin: insights into the catalytic mechanism.
Topics: Amino Acid Sequence; Animals; Binding Sites; Biocatalysis; Carbohydrate Dehydrogenases; Crystallins; Cysteine; Dimerization; Enzyme Stability; Models, Molecular; Molecular Sequence Data; Mutagenesis, Site-Directed; Rabbits; Sequence Homology, Amino Acid; Serine | 2010 |
Oxidative stress, Helicobacter pylori, and OGG1 Ser326Cys, XPC Lys939Gln, and XPD Lys751Gln polymorphisms in a Turkish population with colorectal carcinoma.
Topics: Adult; Aged; Amino Acid Substitution; Colorectal Neoplasms; Cysteine; DNA Glycosylases; DNA-Binding Proteins; Genetics, Population; Glutamine; Helicobacter Infections; Helicobacter pylori; Humans; Lysine; Middle Aged; Mutation, Missense; Oxidative Stress; Polymorphism, Single Nucleotide; Serine; Turkey; Xeroderma Pigmentosum Group D Protein | 2010 |
Cysteine-to-serine mutants dramatically reorder the active site of human ABO(H) blood group B glycosyltransferase without affecting activity: structural insights into cooperative substrate binding.
Topics: ABO Blood-Group System; Amino Acid Substitution; Catalytic Domain; Crystallography, X-Ray; Cysteine; Galactosyltransferases; Humans; Models, Molecular; Mutation, Missense; Protein Binding; Protein Multimerization; Protein Structure, Quaternary; Protein Structure, Tertiary; Serine; Uridine Diphosphate | 2010 |
The 8-oxoguanine glycosylase I (hOGG1) Ser326Cys variant affects the susceptibility to multi-vessel disease in Taiwan coronary artery disease patients.
Topics: Aged; Coronary Artery Disease; Cysteine; DNA Glycosylases; Genotype; Humans; Male; Middle Aged; Polymorphism, Genetic; Risk Factors; Serine; Severity of Illness Index; Taiwan | 2010 |
Prevalence of H63D, S65C, and C282Y hereditary hemochromatosis gene variants in Madeira Island (Portugal).
Topics: Adolescent; Adult; Amino Acid Substitution; Aspartic Acid; Cysteine; Gene Frequency; Genotype; Hemochromatosis; Hemochromatosis Protein; Histidine; Histocompatibility Antigens Class I; Humans; Male; Membrane Proteins; Polymorphism, Single Nucleotide; Portugal; Prevalence; Serine; Tyrosine; Young Adult | 2011 |
Radical formation of amino acid precursors in interstellar regions? Ser, Cys and Asp.
Topics: Aspartic Acid; Cysteine; Nitriles; Serine; Thermodynamics | 2010 |
Insights into the mechanism of dihydropyrimidine dehydrogenase from site-directed mutagenesis targeting the active site loop and redox cofactor coordination.
Topics: Amino Acid Substitution; Animals; Arginine; Catalytic Domain; Cysteine; Dihydrouracil Dehydrogenase (NADP); Electron Spin Resonance Spectroscopy; Flavin-Adenine Dinucleotide; Flavins; Glutamine; Histidine; Hydrogen-Ion Concentration; Iron; Kinetics; Models, Molecular; Mutagenesis, Site-Directed; Mutation; Oxidation-Reduction; Protein Binding; Protein Conformation; Protein Structure, Tertiary; Pyrimidines; Serine; Spectrophotometry; Swine | 2010 |
Redox properties of a thioredoxin-like Arabidopsis protein, AtTDX.
Topics: Amino Acid Motifs; Amino Acid Sequence; Amino Acid Substitution; Arabidopsis; Arabidopsis Proteins; Catalytic Domain; Circular Dichroism; Cysteine; Disulfides; Electrophoresis, Polyacrylamide Gel; Kinetics; Models, Molecular; Molecular Sequence Data; Mutagenesis, Site-Directed; Oxidation-Reduction; Protein Binding; Protein Structure, Tertiary; Sequence Homology, Amino Acid; Serine; Substrate Specificity; Temperature; Thioredoxin-Disulfide Reductase; Thioredoxins; Toluene | 2010 |
Metabolome analysis revealed increase in S-methylcysteine and phosphatidylisopropanolamine synthesis upon L-cysteine deprivation in the anaerobic protozoan parasite Entamoeba histolytica.
Topics: Chromatography, Thin Layer; Cysteine; Cysteine Synthase; Entamoeba histolytica; Gene Expression Regulation; Glycolysis; Kinetics; Metabolomics; Oxidative Stress; Propanolamines; S-Adenosylmethionine; Serine | 2010 |
Cysteine-to-serine shuffling using a Saccharomyces cerevisiae expression system improves protein secretion: case of a nonglycosylated mutant of miraculin, a taste-modifying protein.
Topics: Amino Acid Sequence; Cysteine; Genetic Vectors; Glycoproteins; Molecular Sequence Data; Mutagenesis, Site-Directed; Protein Folding; Recombinant Proteins; Saccharomyces cerevisiae; Serine; Sweetening Agents | 2011 |
The inability of vaccinia virus A33R protein to form intermolecular disulfide-bonded homodimers does not affect the production of infectious extracellular virus.
Topics: Cysteine; Disulfides; HeLa Cells; Humans; Membrane Glycoproteins; Mutagenesis, Site-Directed; Protein Multimerization; Serine; Vaccinia virus; Viral Envelope Proteins; Viral Load; Viral Plaque Assay; Virus Assembly; Virus Replication | 2010 |
Eosinophil cysteinyl leukotriene synthesis mediated by exogenous secreted phospholipase A2 group X.
Topics: Asthma; Calcium; Cysteine; Eicosanoids; Eosinophils; Group X Phospholipases A2; Humans; Leukotrienes; Lysophospholipids; N-Formylmethionine Leucyl-Phenylalanine; p38 Mitogen-Activated Protein Kinases; Phospholipases A2; Phosphorylation; Recombinant Proteins; Serine | 2010 |
A novel ALS SOD1 C6S mutation with implications for aggregation related toxicity and genetic counseling.
Topics: Adult; Aged; Amyotrophic Lateral Sclerosis; Cysteine; Disulfides; DNA Mutational Analysis; Female; Genetic Counseling; Genetic Testing; Genotype; Humans; Male; Mutation; Pedigree; Serine; Superoxide Dismutase; Superoxide Dismutase-1 | 2011 |
Novel oxidative modifications in redox-active cysteine residues.
Topics: Alanine; Amino Acid Sequence; Animals; Catalytic Domain; Cysteine; Glyceraldehyde-3-Phosphate Dehydrogenase (Phosphorylating); HEK293 Cells; Humans; Mass Spectrometry; Mice; Mitochondrial Proteins; Molecular Sequence Data; Mutant Proteins; Nucleoside-Diphosphate Kinase; Oxidation-Reduction; Peptides; Peroxiredoxin VI; Protein Processing, Post-Translational; Recombinant Proteins; Serine; Sulfenic Acids; Sulfinic Acids | 2011 |
Ubiquitylation of an ERAD substrate occurs on multiple types of amino acids.
Topics: Animals; Cell Line; Chlorocebus aethiops; COS Cells; Cysteine; Endoplasmic Reticulum; Humans; Hydrogen-Ion Concentration; Immunoglobulin kappa-Chains; Lysine; Mice; NIH 3T3 Cells; Protein Structure, Tertiary; Protein Unfolding; Saccharomyces cerevisiae Proteins; Serine; Sodium Hydroxide; Substrate Specificity; Threonine; Ubiquitin; Ubiquitin-Protein Ligases; Ubiquitination | 2010 |
Fatty acid modification of Wnt1 and Wnt3a at serine is prerequisite for lipidation at cysteine and is essential for Wnt signalling.
Topics: Amino Acid Sequence; Amino Acid Substitution; Animals; Cell Line; Cysteine; Embryonic Development; Humans; Lipoylation; Mice; Molecular Sequence Data; Mutation; Rats; Serine; Wnt Proteins; Wnt1 Protein; Wnt3 Protein; Wnt3A Protein; Xenopus; Xenopus Proteins | 2011 |
Cysteine S-glycosylation, a new post-translational modification found in glycopeptide bacteriocins.
Topics: Acetylglucosamine; Bacillus subtilis; Bacteriocins; Base Sequence; Circular Dichroism; Cysteine; Glycopeptides; Glycosylation; Gram-Positive Bacteria; Hexosamines; Inhibitory Concentration 50; Lactobacillales; Lactobacillus plantarum; Mass Spectrometry; Molecular Sequence Data; Peptide Fragments; Peptides; Protein Processing, Post-Translational; Protein Sorting Signals; Serine | 2011 |
Association of white matter integrity with genetic variation in an exonic DISC1 SNP.
Topics: Adolescent; Adult; Anisotropy; Brain; Cysteine; Diffusion Magnetic Resonance Imaging; Exons; Female; Genome-Wide Association Study; Genotype; Humans; Male; Nerve Fibers, Myelinated; Nerve Tissue Proteins; Polymorphism, Single Nucleotide; Serine; Young Adult | 2011 |
Structural, dynamic, and chemical characterization of a novel S-glycosylated bacteriocin.
Topics: Acetylglucosamine; Bacteriocins; Cysteine; Disulfides; Glycosylation; Kinetics; Lactobacillus plantarum; Magnetic Resonance Spectroscopy; Models, Molecular; Oxygen; Protein Conformation; Protein Processing, Post-Translational; Protein Structure, Secondary; Serine; Sulfur | 2011 |
The 8-oxoguanine DNA N-glycosylase 1 (hOGG1) Ser326Cys variant affects the susceptibility to Graves' disease.
Topics: Adolescent; Adult; Aged; Amino Acid Substitution; Biomarkers; Cysteine; DNA; DNA Damage; DNA Glycosylases; DNA Repair; Female; Gene Frequency; Genetic Predisposition to Disease; Genotype; Graves Disease; Guanine; Humans; Male; Middle Aged; Oxidative Stress; Polymorphism, Genetic; Reactive Oxygen Species; Risk; Serine; Young Adult | 2011 |
Identification and enzymic analysis of a novel protein associated with production of hydrogen sulfide and L-serine from L-cysteine in Fusobacterium nucleatum subsp. nucleatum ATCC 25586.
Topics: Bacterial Proteins; Chromatography, Gas; Chromatography, High Pressure Liquid; Cysteine; Cysteine Synthase; Escherichia coli; Fusobacterium nucleatum; Hydrogen Sulfide; Kinetics; Serine | 2011 |
Redox chemistry of the Schizosaccharomyces pombe ferredoxin electron-transfer domain and influence of Cys to Ser substitutions.
Topics: Amino Acid Substitution; Circular Dichroism; Cysteine; Ferredoxin-NADP Reductase; Ferredoxins; Iron-Sulfur Proteins; Mutagenesis, Site-Directed; NADP; Oxidation-Reduction; Schizosaccharomyces; Schizosaccharomyces pombe Proteins; Serine; Thermodynamics | 2011 |
Role of disulfide bridges in archaeal family-B DNA polymerases.
Topics: Amino Acid Sequence; Calorimetry, Differential Scanning; Cysteine; Disulfides; DNA-Directed DNA Polymerase; DNA, Archaeal; Models, Molecular; Molecular Sequence Data; Polymerase Chain Reaction; Protein Folding; Sequence Alignment; Serine; Temperature | 2011 |
Characterization of the structure and function of Klebsiella pneumoniae allantoin racemase.
Topics: Allantoin; Amino Acid Substitution; Bacterial Proteins; Binding Sites; Biocatalysis; Catalytic Domain; Crystallography, X-Ray; Cysteine; Humans; Kinetics; Klebsiella Infections; Klebsiella pneumoniae; Models, Molecular; Mutation; Protein Multimerization; Protein Structure, Quaternary; Protein Structure, Secondary; Racemases and Epimerases; Serine; Stereoisomerism; Substrate Specificity | 2011 |
Comparative thermodynamic studies on substrate and product binding of O-acetylserine sulfhydrylase reveals two different ligand recognition modes.
Topics: Calorimetry; Cysteine; Cysteine Synthase; Entropy; Haemophilus influenzae; Ligands; Methionine; Mycobacterium tuberculosis; Salmonella typhimurium; Serine; Sodium Chloride; Spectrometry, Fluorescence; Temperature; Thermodynamics | 2011 |
Characterization of human-type monoclonal antibodies against reduced form of hemin binding protein 35 from Porphyromonas gingivalis.
Topics: Amino Acid Substitution; Animals; Antibodies, Monoclonal, Humanized; Bacterial Proteins; Carrier Proteins; Cysteine; Heme-Binding Proteins; Hemeproteins; Hemin; Humans; Immunization, Passive; Mice; Mice, Transgenic; Porphyromonas gingivalis; Protein Binding; Protein Structure, Tertiary; Serine; Thioredoxins; Virulence Factors | 2011 |
Effects of gamma-ray-induced free radicals on the metal content and amino acid composition of human metallothionein-1.
Topics: Butyrates; Cystathionine; Cysteine; Gamma Rays; Homocysteine; Humans; Metallothionein; Methionine; Serine; Zinc | 2011 |
Amide bonds to the nitrogen atoms of cysteine and serine as "weak points" in the backbones of proteins.
Topics: Amides; Amino Acids; Cysteine; Hydrolysis; Nitrogen; Protein Splicing; Proteins; Serine | 2011 |
The metastasis-promoting phosphatase PRL-3 shows activity toward phosphoinositides.
Topics: Amino Acid Sequence; Catalysis; Cell Movement; Cysteine; Enzyme Activation; Genetic Variation; HEK293 Cells; Humans; Molecular Sequence Data; Mutation; Neoplasm Invasiveness; Neoplasm Proteins; Phosphatidylinositols; Protein Tyrosine Phosphatases; Recombinant Proteins; Serine; Substrate Specificity | 2011 |
Changes in cysteine and O-acetyl-L-serine levels in the microalga Chlorella sorokiniana in response to the S-nutritional status.
Topics: Cysteine; Glutathione; Microalgae; Serine; Sulfates | 2011 |
Hb Riesa or β93 (F9) Cys→Ser, a new electrophoretically silent haemoglobin variant interfering with haemoglobin A1c measurement.
Topics: Amino Acid Sequence; Amino Acid Substitution; beta-Globins; Chromatography, High Pressure Liquid; Cysteine; Diabetes Mellitus, Type 1; Genetic Variation; Glycated Hemoglobin; Humans; Male; Middle Aged; Molecular Sequence Data; Mutation, Missense; Serine; Spectrometry, Mass, Electrospray Ionization | 2011 |
Acid-base thermochemistry of gaseous oxygen and sulfur substituted amino acids (Ser, Thr, Cys, Met).
Topics: Amino Acids; Cysteine; Gases; Methionine; Oxygen; Quantum Theory; Serine; Sulfur; Thermodynamics; Threonine | 2011 |
Cortisol responses to emotional stress in men: association with a functional polymorphism in the 5HTR2C gene.
Topics: Adolescent; Adult; Cysteine; Genetic Association Studies; Genotype; Humans; Hydrocortisone; Male; Middle Aged; Polymorphism, Single Nucleotide; Psychiatric Status Rating Scales; Radioimmunoassay; Receptor, Serotonin, 5-HT2C; Serine; Statistics as Topic; Stress, Psychological; Young Adult | 2012 |
Nse1-dependent recruitment of Smc5/6 to lesion-containing loci contributes to the repair defects of mutant complexes.
Topics: Amino Acid Substitution; Cell Cycle Proteins; Chromosomal Proteins, Non-Histone; Cysteine; DNA Damage; DNA Helicases; DNA Repair; DNA-Binding Proteins; Homologous Recombination; Mitosis; Nuclear Proteins; Point Mutation; Protein Structure, Tertiary; Rad52 DNA Repair and Recombination Protein; S Phase; Schizosaccharomyces; Schizosaccharomyces pombe Proteins; Serine | 2011 |
Structural insight into the role of the human melanocortin 3 receptor cysteine residues on receptor function.
Topics: Amino Acid Sequence; Amino Acid Substitution; Cyclic AMP; Cysteine; HEK293 Cells; Humans; Molecular Sequence Data; Mutagenesis, Site-Directed; Mutation; Protein Binding; Protein Structure, Tertiary; Receptor, Melanocortin, Type 3; Sequence Alignment; Serine; Signal Transduction; Structure-Activity Relationship; Transfection | 2011 |
The role of a disulfide bridge in the stability and folding kinetics of Arabidopsis thaliana cytochrome c(6A).
Topics: Amino Acid Sequence; Arabidopsis; Cyanobacteria; Cysteine; Cytochromes c6; Disulfides; Heme; Hydrogen-Ion Concentration; Kinetics; Molecular Sequence Data; Oxidation-Reduction; Protein Folding; Protein Structure, Tertiary; Serine; Thermodynamics | 2012 |
CysK from Lactobacillus casei encodes a protein with O-acetylserine sulfhydrylase and cysteine desulfurization activity.
Topics: Carbon-Sulfur Lyases; Cloning, Molecular; Cysteine; Cysteine Synthase; DNA, Bacterial; Escherichia coli; Gene Expression; Gene Expression Profiling; Genetic Complementation Test; Hydrogen-Ion Concentration; Kinetics; Lacticaseibacillus casei; Mass Spectrometry; Molecular Sequence Data; Real-Time Polymerase Chain Reaction; Recombinant Proteins; Sequence Analysis, DNA; Serine | 2012 |
Biogenesis of Weibel-Palade bodies in von Willebrand's disease variants with impaired von Willebrand factor intrachain or interchain disulfide bond formation.
Topics: Cysteine; Disulfides; Endoplasmic Reticulum; HEK293 Cells; Humans; Models, Biological; Mutation; Plasmids; Protein Conformation; Protein Folding; Protein Multimerization; Protein Subunits; Serine; Transfection; Tyrosine; von Willebrand Diseases; von Willebrand Factor; Weibel-Palade Bodies | 2012 |
The disulfide isomerase ERp57 mediates platelet aggregation, hemostasis, and thrombosis.
Topics: Animals; Cysteine; Hemostasis; Humans; Male; Mice; Mice, Inbred C57BL; Mutagenesis, Site-Directed; Mutant Proteins; Platelet Aggregation; Protein Disulfide-Isomerases; Rabbits; Serine; Thrombosis | 2012 |
Cu(I) affinities of the domain 1 and 3 sites in the human metallochaperone for Cu,Zn-superoxide dismutase.
Topics: Amino Acid Motifs; Binding Sites; Chromatography, Gel; Cloning, Molecular; Copper; Cysteine; Cytosol; Dose-Response Relationship, Drug; Escherichia coli; Humans; Hydrogen-Ion Concentration; Kinetics; Mutagenesis, Site-Directed; Protein Binding; Protein Structure, Tertiary; Serine; Spectrophotometry, Atomic; Superoxide Dismutase | 2012 |
Prothrombin Mumbai causes severe prothrombin deficiency due to a novel Cys90Ser mutation.
Topics: Cysteine; Female; Humans; Hypoprothrombinemias; Infant; Mutation; Prothrombin; Serine; Severity of Illness Index | 2012 |
Repair of oxidative DNA damage is delayed in the Ser326Cys polymorphic variant of the base excision repair protein OGG1.
Topics: Animals; Antimetabolites; Blotting, Western; Buthionine Sulfoximine; Cells, Cultured; Cysteine; Deoxyadenosines; DNA Damage; DNA Glycosylases; DNA Repair; Embryo, Mammalian; Fibroblasts; Flow Cytometry; Gene-Environment Interaction; Glutathione; Humans; Mice; Mice, Knockout; Mutation Rate; Oxidative Stress; Polymorphism, Genetic; Reactive Oxygen Species; Real-Time Polymerase Chain Reaction; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Serine; Up-Regulation | 2012 |
Metal cation dependence of interactions with amino acids: bond energies of Cs+ to Gly, Pro, Ser, Thr, and Cys.
Topics: Cations; Cesium; Cysteine; Glycine; Proline; Quantum Theory; Serine; Threonine | 2012 |
Mutation of Ser-50 and Cys-66 in Snapin modulates protein structure and stability.
Topics: Cysteine; Mutation; Protein Conformation; Protein Stability; Protein Structure, Secondary; Serine; SNARE Proteins; Spectroscopy, Fourier Transform Infrared; Vesicular Transport Proteins | 2012 |
Interactions of organophosphates with keratins in the cornified epithelium of human skin.
Topics: Binding Sites; Chemical Warfare Agents; Cysteine; Humans; Keratins; Organophosphates; Organothiophosphorus Compounds; Paraoxon; Peptide Fragments; Pronase; Serine; Skin; Tandem Mass Spectrometry; Trypsin; Tyrosine | 2012 |
Cysteine biosynthesis, in concert with a novel mechanism, contributes to sulfide detoxification in mitochondria of Arabidopsis thaliana.
Topics: Arabidopsis; Carbon-Oxygen Lyases; Cyanides; Cysteine; Cytosol; Electron Transport Complex II; Electron Transport Complex III; Electron Transport Complex IV; Inactivation, Metabolic; Iron-Sulfur Proteins; Mitochondria; Phenotype; Plastids; Seedlings; Serine; Sulfides | 2012 |
WhiB2/Rv3260c, a cell division-associated protein of Mycobacterium tuberculosis H37Rv, has properties of a chaperone.
Topics: Adenosine Triphosphate; Bacterial Proteins; Base Sequence; Cell Division; Chemical Precipitation; Citrate (si)-Synthase; Cysteine; DNA, Bacterial; Genes, Bacterial; Insulin; Molecular Chaperones; Mutagenesis, Site-Directed; Mycobacterium tuberculosis; Oxidation-Reduction; Protein Denaturation; Serine | 2012 |
Mitochondrial cysteine synthase complex regulates O-acetylserine biosynthesis in plants.
Topics: Arabidopsis; Arabidopsis Proteins; Biological Transport; Cysteine; Cysteine Synthase; Magnetic Resonance Spectroscopy; Mitochondria; Mitochondrial Proteins; Models, Biological; Serine; Serine O-Acetyltransferase | 2012 |
miR395 is a general component of the sulfate assimilation regulatory network in Arabidopsis.
Topics: Anion Transport Proteins; Arabidopsis; Arabidopsis Proteins; Buthionine Sulfoximine; Cysteine; DNA-Binding Proteins; Gene Expression Regulation, Plant; Genes, Plant; Metabolic Networks and Pathways; MicroRNAs; Models, Biological; Plants, Genetically Modified; RNA, Plant; Serine; Sulfates; Transcription Factors | 2012 |
A chemical approach to mapping nucleosomes at base pair resolution in yeast.
Topics: Base Composition; Base Pairing; Chromosome Mapping; Chromosomes, Fungal; Computational Biology; Cysteine; DNA, Fungal; Genome, Fungal; Histones; Mutagenesis; Nucleosomes; Phenotype; Saccharomyces cerevisiae; Serine; Transcription Factors | 2012 |
Effects of a buried cysteine-to-serine mutation on yeast triosephosphate isomerase structure and stability.
Topics: Binding Sites; Catalysis; Crystallography, X-Ray; Cysteine; Kinetics; Models, Molecular; Molecular Dynamics Simulation; Mutation; Protein Conformation; Saccharomyces cerevisiae; Serine; Triose-Phosphate Isomerase | 2012 |
Guanylylation-competent replication proteins of Tomato mosaic virus are disulfide-linked.
Topics: Amino Acid Substitution; Bromovirus; Cucumovirus; Cysteine; Disulfides; Guanosine Monophosphate; Mutagenesis, Site-Directed; Nicotiana; Protein Binding; Serine; Tobamovirus; Viral Proteins; Virus Replication | 2012 |
Transcripts of sulphur metabolic genes are co-ordinately regulated in developing seeds of common bean lacking phaseolin and major lectins.
Topics: Amino Acids; Cluster Analysis; Cysteine; Gene Expression Profiling; Gene Expression Regulation, Plant; Lectins; Methionine; Oligonucleotide Array Sequence Analysis; Phaseolus; Plant Proteins; RNA, Messenger; RNA, Plant; Seed Storage Proteins; Seeds; Serine; Sulfur | 2012 |
Recent trends in Cys- and Ser/Thr-based synthetic strategies for the elaboration of peptide constructs.
Topics: Cysteine; Esterification; Imines; Ionic Liquids; Peptides; Serine; Solvents; Sulfur; Threonine; Water | 2012 |
Control of STN7 transcript abundance and transient STN7 dimerisation are involved in the regulation of STN7 activity.
Topics: Arabidopsis; Arabidopsis Proteins; Cysteine; Cytochrome b6f Complex; Disulfides; Dithiothreitol; Diuron; Enzyme Activation; Light; Light-Harvesting Protein Complexes; Oxidation-Reduction; Phosphorylation; Photosystem II Protein Complex; Protein Multimerization; Protein Processing, Post-Translational; Protein Serine-Threonine Kinases; RNA, Messenger; Serine; Time Factors | 2013 |
Detection of reaction intermediates during human cystathionine β-synthase-monitored turnover and H2S production.
Topics: Cystathionine beta-Synthase; Cysteine; Heme; Homocysteine; Humans; Hydrogen Sulfide; Kinetics; Serine | 2012 |
Solid phase versus solution phase synthesis of heterocyclic macrocycles.
Topics: Cyclization; Cysteine; Leucine; Oxidation-Reduction; Peptides, Cyclic; Serine; Solid-Phase Synthesis Techniques; Solutions; Thiazoles | 2013 |
Increasing effects of S-methyl-L-cysteine on the extracellular D-serine concentrations in the rat medial frontal cortex.
Topics: Amino Acid Transport Systems, Neutral; Amino Acids; Animals; Cysteine; Extracellular Fluid; Frontal Lobe; Infusions, Intraventricular; Male; Microdialysis; Rats; Rats, Wistar; Serine | 2013 |
Single residue mutation in active site of serine acetyltransferase isoform 3 from Entamoeba histolytica assists in partial regaining of feedback inhibition by cysteine.
Topics: Amino Acid Sequence; Catalytic Domain; Cysteine; Entamoeba histolytica; Feedback, Physiological; Humans; Isoenzymes; Kinetics; Molecular Dynamics Simulation; Molecular Sequence Data; Mutagenesis, Site-Directed; Mutation; Sequence Alignment; Serine; Serine O-Acetyltransferase; Substrate Specificity; Thermodynamics | 2013 |
Further characterization of Cys-type and Ser-type anaerobic sulfatase maturating enzymes suggests a commonality in the mechanism of catalysis.
Topics: Amino Acid Sequence; Anaerobiosis; Base Sequence; Catalysis; Chromatography, Gel; Cloning, Molecular; Clostridium perfringens; Cysteine; DNA Primers; Electrons; Genes, Bacterial; Mass Spectrometry; Molecular Sequence Data; Mutagenesis, Site-Directed; Oxidation-Reduction; Serine; Spectrophotometry, Ultraviolet; Sulfatases | 2013 |
Enzymatic synthesis of S-phenyl-L-cysteine from keratin hydrolysis industries wastewater with tryptophan synthase.
Topics: Ammonium Chloride; Animals; Chromatography, Thin Layer; Cysteine; Escherichia coli; Fermentation; Hydrogen-Ion Concentration; Hydrolysis; Industrial Waste; Keratins; Serine; Surface-Active Agents; Temperature; Tryptophan Synthase; Wastewater | 2013 |
An enzymatic route to selenazolines.
Topics: Amino Acid Sequence; Cysteine; Iodoacetamide; Multienzyme Complexes; Oxazoles; Peptides, Cyclic; Selenium; Selenocysteine; Serine; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Thiazoles; Threonine | 2013 |
Relationship between a point mutation S97C in CK1δ protein and its affect on ATP-binding affinity.
Topics: Adenosine Triphosphate; Breast Neoplasms; Carcinoma, Ductal, Breast; Casein Kinase Idelta; Computer Simulation; Cysteine; Female; Humans; Molecular Docking Simulation; Molecular Dynamics Simulation; Point Mutation; Serine; Signal Transduction | 2014 |
Synthesis and conformational analysis of neoglycoconjugates derived from O- and S-glucose.
Topics: Carbohydrate Conformation; Chemistry Techniques, Synthetic; Cysteine; Glucose; Glycoconjugates; Magnetic Resonance Spectroscopy; Molecular Dynamics Simulation; Serine | 2013 |
Direct targeting of Arabidopsis cysteine synthase complexes with synthetic polypeptides to selectively deregulate cysteine synthesis.
Topics: Amino Acid Sequence; Arabidopsis; Cysteine; Cysteine Synthase; Molecular Sequence Data; Peptides; Plants, Genetically Modified; Sequence Alignment; Serine; Serine O-Acetyltransferase | 2013 |
Voltage-dependent processes in the electroneutral amino acid exchanger ASCT2.
Topics: Alanine; Amino Acid Sequence; Amino Acid Transport System ASC; Animals; Binding Sites; Cysteine; HEK293 Cells; Humans; Membrane Potentials; Minor Histocompatibility Antigens; Molecular Dynamics Simulation; Molecular Sequence Data; Protein Structure, Tertiary; Rats; Serine; Sodium | 2013 |
Mechanism-based inhibition of iPLA2β demonstrates a highly reactive cysteine residue (C651) that interacts with the active site: mass spectrometric elucidation of the mechanisms underlying inhibition.
Topics: Animals; Catalysis; Catalytic Domain; Crystallography, X-Ray; Cysteine; Drug Design; Hydrolysis; Insecta; Lipids; Mass Spectrometry; Models, Chemical; Phospholipases A2, Calcium-Independent; Serine; Spectrophotometry | 2013 |
Mutation of active site serine residue with cysteine displays change in acyl-acceptor preference of β-peptidyl aminopeptidase from Pseudomonas aeruginosa PAO1.
Topics: Aminopeptidases; Catalysis; Catalytic Domain; Cysteine; Mutation; Pseudomonas aeruginosa; Serine | 2014 |
Parkin-catalyzed ubiquitin-ester transfer is triggered by PINK1-dependent phosphorylation.
Topics: Animals; Binding Sites; Biocatalysis; Carbonyl Cyanide m-Chlorophenyl Hydrazone; Cells, Cultured; Cysteine; Embryo, Mammalian; Esters; Fibroblasts; HEK293 Cells; HeLa Cells; Humans; Immunoblotting; Membrane Potential, Mitochondrial; Mice; Mice, Knockout; Models, Biological; Phosphorylation; Protein Kinases; Proton Ionophores; Serine; Substrate Specificity; Ubiquitin; Ubiquitin-Protein Ligases; Ubiquitination | 2013 |
Crystal structure of the Plasmodium falciparum thioredoxin reductase-thioredoxin complex.
Topics: Amino Acid Substitution; Antimalarials; Binding Sites; Crystallography, X-Ray; Cysteine; Humans; Models, Biological; Models, Molecular; Multiprotein Complexes; Plasmodium falciparum; Protein Interaction Domains and Motifs; Protein Structure, Quaternary; Protein Structure, Secondary; Serine; Thioredoxin-Disulfide Reductase; Thioredoxins | 2013 |
Metal switch-controlled myosin II from Dictyostelium discoideum supports closure of nucleotide pocket during ATP binding coupled to detachment from actin filaments.
Topics: Actin Cytoskeleton; Actins; Adenosine Triphosphatases; Adenosine Triphosphate; Allosteric Site; Cysteine; Dictyostelium; Gene Expression Regulation; Hydrolysis; Magnesium; Manganese; Metals; Myosin Type II; Nucleotides; Protein Binding; Protein Structure, Tertiary; Serine | 2013 |
Visualization of imbalances in sulfur assimilation and synthesis of sulfur-containing amino acids at the single-cell level.
Topics: Amino Acids; Corynebacterium glutamicum; Cysteine; Cytoplasm; Homoserine; Microscopy, Fluorescence; Serine; Single-Cell Analysis; Sulfur | 2013 |
The presence of modifiable residues in the core peptide part of precursor nisin is not crucial for precursor nisin interactions with NisB- and NisC.
Topics: Anti-Infective Agents; Bacterial Proteins; Cloning, Molecular; Cysteine; Genetic Variation; Intramolecular Lyases; Lactococcus lactis; Membrane Proteins; Nisin; Peptides; Plasmids; Protein Binding; Protein Engineering; Protein Structure, Tertiary; Recombination, Genetic; Serine; Substrate Specificity; Threonine | 2013 |
Combined effects of polymorphisms of DNA-repair protein genes and metabolic enzyme genes on the risk of cholangiocarcinoma.
Topics: Alanine; Arginine; Bile Duct Neoplasms; Bile Ducts, Intrahepatic; Cholangiocarcinoma; Cysteine; DNA Glycosylases; DNA Repair; DNA-Binding Proteins; Genotype; Glutamine; Glutathione Transferase; Histidine; Humans; Poly (ADP-Ribose) Polymerase-1; Poly(ADP-ribose) Polymerases; Polymerase Chain Reaction; Polymorphism, Single Nucleotide; Risk Assessment; Risk Factors; Serine; Valine; X-ray Repair Cross Complementing Protein 1 | 2013 |
DISC1 Ser704Cys impacts thalamic-prefrontal connectivity.
Topics: Adolescent; Adult; Afferent Pathways; Brain Mapping; Chi-Square Distribution; Cysteine; Female; Humans; Imaging, Three-Dimensional; Magnetic Resonance Imaging; Male; Nerve Tissue Proteins; Oxygen; Prefrontal Cortex; Serine; Thalamus; Young Adult | 2015 |
Bio-inspired band gap engineering of zinc oxide by intracrystalline incorporation of amino acids.
Topics: Amino Acids; Arginine; Biomimetic Materials; Crystallization; Cysteine; Feasibility Studies; Glutamic Acid; Microscopy, Electrochemical, Scanning; Nitrogen; Photoelectron Spectroscopy; Selenocysteine; Semiconductors; Serine; X-Ray Diffraction; Zinc Oxide | 2014 |
The sensitive balance between the fully folded and locally unfolded conformations of a model peroxiredoxin.
Topics: Amino Acid Substitution; Catalytic Domain; Crystallography, X-Ray; Cysteine; Models, Molecular; Peroxiredoxins; Protein Folding; Protein Structure, Tertiary; Salmonella typhimurium; Serine; Structure-Activity Relationship; Thermodynamics | 2013 |
Investigation of LKB1 Ser431 phosphorylation and Cys433 farnesylation using mouse knockin analysis reveals an unexpected role of prenylation in regulating AMPK activity.
Topics: Adenylate Kinase; Amino Acid Sequence; AMP-Activated Protein Kinases; Animals; Cysteine; HEK293 Cells; Humans; Mice; Molecular Sequence Data; Phosphorylation; Protein Prenylation; Protein Serine-Threonine Kinases; Serine | 2014 |
Intramolecular disulfide bond of Tim22 protein maintains integrity of the TIM22 complex in the mitochondrial inner membrane.
Topics: Amino Acid Sequence; Antiporters; Cysteine; Disulfides; Mitochondria; Mitochondrial Membrane Transport Proteins; Mitochondrial Membranes; Mitochondrial Precursor Protein Import Complex Proteins; Models, Biological; Molecular Sequence Data; Multiprotein Complexes; Mutant Proteins; Mutation; Protein Binding; Protein Stability; Protein Transport; Proteolysis; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Serine; Temperature | 2014 |
A close look at a ketosynthase from a trans-acyltransferase modular polyketide synthase.
Topics: Amino Acid Sequence; Amino Acid Substitution; Catalytic Domain; Crystallography, X-Ray; Cysteine; Mass Spectrometry; Models, Molecular; Molecular Sequence Data; Mutation; Polyketide Synthases; Protein Conformation; Serine; Substrate Specificity | 2014 |
Defining membrane spanning domains and crucial membrane-localized acidic amino acid residues for K⁺ transport of a Kup/HAK/KT-type Escherichia coli potassium transporter.
Topics: Amino Acid Sequence; Amino Acid Substitution; Biological Transport; Cell Membrane; Cysteine; Escherichia coli; Escherichia coli Proteins; Histidine; Hydrogen-Ion Concentration; Molecular Sequence Data; Potassium; Protein Structure, Tertiary; Serine | 2014 |
Expression of Porphyromonas gingivalis gingipain antigen Hgp44 domain on surface of Lactococcus lactis.
Topics: Adhesins, Bacterial; Antibodies, Bacterial; Antigens, Bacterial; Antigens, Surface; Bacterial Proteins; Bacterial Vaccines; Cysteine; Cysteine Endopeptidases; Escherichia coli; Feasibility Studies; Gingipain Cysteine Endopeptidases; Hemagglutinins; Humans; Immunization; Immunoblotting; Lactococcus lactis; Mutagenesis, Site-Directed; Plasmids; Porphyromonas gingivalis; Recombinant Proteins; Serine | 2013 |
Traceless chemical ligation from S-, O-, and N-acyl isopeptides.
Topics: Acylation; Biochemistry; Cysteine; Homocysteine; Peptides; Peptides, Cyclic; Serine; Solid-Phase Synthesis Techniques; Tryptophan; Tyrosine | 2014 |
Characterization and structural analysis of human selenium-dependent glutathione peroxidase 4 mutant expressed in Escherichia coli.
Topics: Cloning, Molecular; Cysteine; Escherichia coli; Gene Expression; Glutathione Peroxidase; Humans; Models, Molecular; Mutation; Phospholipid Hydroperoxide Glutathione Peroxidase; Plasmids; Protein Engineering; Recombinant Proteins; Selenocysteine; Serine | 2014 |
Mechanism of oxidant-induced mistranslation by threonyl-tRNA synthetase.
Topics: Cysteine; Escherichia coli Proteins; Histidine; Hydrogen Peroxide; Oxidants; Oxidative Stress; Peptide Elongation Factor Tu; RNA, Transfer, Thr; Serine; Sulfenic Acids; Threonine-tRNA Ligase; Transfer RNA Aminoacylation | 2014 |
Effects of pH and lactate on hydrogen sulfide production by oral Veillonella spp.
Topics: Alanine; Ammonia; Cystathionine beta-Synthase; Cystathionine gamma-Lyase; Cysteine; Hydrogen Sulfide; Hydrogen-Ion Concentration; Lactic Acid; Serine; Sulfides; Veillonella | 2014 |
L-Cysteine inhibits root elongation through auxin/PLETHORA and SCR/SHR pathway in Arabidopsis thaliana.
Topics: Arabidopsis; Arabidopsis Proteins; Buthionine Sulfoximine; Cysteine; Down-Regulation; Green Fluorescent Proteins; Indoleacetic Acids; Meristem; Oxidation-Reduction; Peroxisomes; Plant Roots; Serine; Signal Transduction; Stem Cell Niche; Transcription Factors | 2015 |
A zinc linchpin motif in the MUTYH glycosylase interdomain connector is required for efficient repair of DNA damage.
Topics: Amino Acid Sequence; Animals; Cysteine; DNA Damage; DNA Glycosylases; DNA Repair Enzymes; Humans; Kinetics; Mice; Models, Molecular; Molecular Sequence Data; Mutagenesis; Protein Conformation; Serine; Zinc Compounds | 2014 |
Novel cysteine-centered sulfur metabolic pathway in the thermotolerant methylotrophic yeast Hansenula polymorpha.
Topics: Amino Acid Sequence; Amino Acids, Sulfur; Carbon; Cysteine; Fungal Proteins; Gene Deletion; Glutathione; Metabolic Networks and Pathways; Molecular Sequence Data; Mutation; Pichia; Reproducibility of Results; Sequence Alignment; Serine; Sulfur | 2014 |
The influence of Ser-154, Cys-113, and the phosphorylated threonine residue on the catalytic reaction mechanism of Pin1.
Topics: Binding Sites; Biocatalysis; Catalytic Domain; Cysteine; Humans; Hydrogen Bonding; Isomerism; Molecular Dynamics Simulation; NIMA-Interacting Peptidylprolyl Isomerase; Peptidylprolyl Isomerase; Phosphorylation; Quantum Theory; Serine; Static Electricity; Substrate Specificity; Thermodynamics; Threonine | 2014 |
Germination of Aspergillus niger conidia is triggered by nitrogen compounds related to L-amino acids.
Topics: Amino Acids; Aspergillus nidulans; Aspergillus niger; Carbon Radioisotopes; Cysteine; Deoxyglucose; Galactose; Hyphae; Nitrogen Compounds; Serine; Spores, Fungal; Valine | 2014 |
The possible implication of the S250C variant of the autoimmune regulator protein in a patient with autoimmunity and immunodeficiency: in silico analysis suggests a molecular pathogenic mechanism for the variant.
Topics: Adolescent; AIRE Protein; Amino Acid Sequence; Amino Acid Substitution; Autoimmunity; Cysteine; Humans; Immunologic Deficiency Syndromes; Male; Models, Molecular; Molecular Sequence Data; Pedigree; Polyendocrinopathies, Autoimmune; Sequence Homology, Amino Acid; Serine; Transcription Factors | 2014 |
Phosphorylation within the cysteine-rich region of dystrophin enhances its association with β-dystroglycan and identifies a potential novel therapeutic target for skeletal muscle wasting.
Topics: Amino Acid Sequence; Animals; Cell Differentiation; Cell Line; Cysteine; Dystroglycans; Dystrophin; Dystrophin-Associated Proteins; Gene Expression Regulation; HEK293 Cells; Humans; Mice; Mice, Inbred C57BL; Mice, Inbred mdx; Models, Molecular; Molecular Sequence Data; Muscle, Skeletal; Muscular Atrophy; Myoblasts; Phosphorylation; Recombinant Fusion Proteins; Serine; Signal Transduction | 2014 |
Rationalization of the pKa values of alcohols and thiols using atomic charge descriptors and its application to the prediction of amino acid pKa's.
Topics: Alcohols; Cysteine; Models, Chemical; Phenols; Proteins; Quantum Theory; Serine; Static Electricity; Sulfhydryl Compounds; Thermodynamics; Tyrosine; Water | 2014 |
The Disrupted-in-Schizophrenia-1 Ser704Cys polymorphism and brain neurodevelopmental markers in schizophrenia and healthy subjects.
Topics: Adult; Analysis of Variance; Brain; Chi-Square Distribution; Cysteine; Female; Functional Laterality; Genotype; Humans; Magnetic Resonance Imaging; Male; Nerve Tissue Proteins; Polymorphism, Single Nucleotide; Psychiatric Status Rating Scales; Schizophrenia; Serine; Young Adult | 2015 |
Examination of the dimerization states of the single-stranded RNA recognition protein pentatricopeptide repeat 10 (PPR10).
Topics: Adenine; Amino Acid Sequence; Arabidopsis; Chloroplast Proteins; Chloroplasts; Codon; Crystallization; Cysteine; Molecular Sequence Data; Nucleic Acids; Plant Proteins; Point Mutation; Protein Binding; Protein Multimerization; Protein Structure, Tertiary; RNA-Binding Proteins; Sequence Homology, Amino Acid; Serine; Zea mays | 2014 |
Covalent docking of large libraries for the discovery of chemical probes.
Topics: Animals; Bacterial Proteins; beta-Lactamase Inhibitors; beta-Lactamases; COS Cells; Cysteine; Drug Discovery; Gram-Negative Bacteria; Humans; Hydrophobic and Hydrophilic Interactions; Janus Kinase 3; Ligands; Molecular Docking Simulation; Molecular Probes; Protein Binding; Protein Kinase Inhibitors; Recombinant Proteins; Ribosomal Protein S6 Kinases, 90-kDa; Serine; Small Molecule Libraries | 2014 |
Overcoming mantle cell lymphoma's ibrutinib resistance.
Topics: Adenine; Agammaglobulinaemia Tyrosine Kinase; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Cyclin-Dependent Kinases; Cysteine; Drug Resistance, Neoplasm; Humans; Lymphoma, Mantle-Cell; Mutation; Piperazines; Piperidines; Protein Kinase Inhibitors; Protein-Tyrosine Kinases; Purines; Pyrazoles; Pyridines; Pyrimidines; Quinazolinones; Serine | 2014 |
Traceless splicing enabled by substrate-induced activation of the Nostoc punctiforme Npu DnaE intein after mutation of a catalytic cysteine to serine.
Topics: Aldehyde-Lyases; Amino Acid Sequence; Bacterial Proteins; Blotting, Western; Catalytic Domain; Cysteine; DNA Polymerase III; Enzyme Activation; Escherichia coli Proteins; Exteins; Inteins; Molecular Sequence Data; Mutation, Missense; Nostoc; Protein Splicing; Serine; Substrate Specificity; Threonine | 2014 |
Intra-residue interactions in proteins: interplay between serine or cysteine side chains and backbone conformations, revealed by laser spectroscopy of isolated model peptides.
Topics: Cysteine; Hydrogen Bonding; Molecular Conformation; Peptides; Protein Structure, Secondary; Proteins; Serine | 2015 |
Reduced HRAS G12V-Driven Tumorigenesis of Cell Lines Expressing KRAS C118S.
Topics: Amino Acid Substitution; Animals; Cell Line; Cell Transformation, Neoplastic; Cysteine; Female; Fibroblasts; Gene Expression Regulation, Neoplastic; Gene Knock-In Techniques; GTP Phosphohydrolases; HEK293 Cells; Humans; Membrane Proteins; Mice; Mice, SCID; Mutagenesis, Site-Directed; Mutation; Oxidation-Reduction; Proto-Oncogene Proteins p21(ras); Serine; Signal Transduction; Transplantation, Heterologous | 2015 |
In Vitro Study of L-Glutamate and L-Glutamine Transport in Retinal Pericytes: Involvement of Excitatory Amino Acid Transporter 1 and Alanine-Serine-Cysteine Transporter 2.
Topics: Alanine; Amino Acid Transport System ASC; Animals; Aspartic Acid; Cysteine; Excitatory Amino Acid Transporter 1; Glutamic Acid; Glutamine; Ion Transport; Male; Minor Histocompatibility Antigens; Pericytes; Rats, Wistar; Retina; Serine | 2015 |
Impact of cysteine variants on the structure, activity, and stability of recombinant human α-galactosidase A.
Topics: alpha-Galactosidase; Cysteine; Disulfides; HEK293 Cells; Humans; Mutagenesis, Site-Directed; Protein Folding; Recombinant Proteins; Serine; Structure-Activity Relationship | 2015 |
A Protein Extract from Chicken Reduces Plasma Homocysteine in Rats.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Animals; Betaine; Betaine-Homocysteine S-Methyltransferase; Caseins; Chickens; Choline; Cystathionine gamma-Lyase; Cysteine; Dietary Proteins; Folic Acid; Glycine; Homocysteine; Liver; Male; Meat; Methionine; Rats; Rats, Wistar; Riboflavin; RNA, Messenger; Sarcosine; Serine; Vitamin B 12; Vitamin B 6 | 2015 |
Far infrared spectra of solid state L-serine, L-threonine, L-cysteine, and L-methionine in different protonation states.
Topics: Cysteine; Methionine; Models, Molecular; Molecular Conformation; Protons; Serine; Spectroscopy, Fourier Transform Infrared; Spectrum Analysis, Raman; Threonine; Vibration; Water | 2015 |
Site-directed mutagenesis substituting cysteine for serine in 2-Cys peroxiredoxin (2-Cys Prx A) of Arabidopsis thaliana effectively improves its peroxidase and chaperone functions.
Topics: Arabidopsis; Arabidopsis Proteins; Cysteine; Molecular Chaperones; Mutagenesis, Site-Directed; Peroxidase; Peroxiredoxins; Serine | 2015 |
Phenothiazine-based CaaX competitive inhibitors of human farnesyltransferase bearing a cysteine, methionine, serine or valine moiety as a new family of antitumoral compounds.
Topics: Amino Acids; Antineoplastic Agents; Cysteine; Dose-Response Relationship, Drug; Enzyme Inhibitors; Farnesyltranstransferase; Humans; Methionine; Molecular Structure; Phenothiazines; Serine; Structure-Activity Relationship; Valine | 2015 |
The effect of disulfide bond introduction and related Cys/Ser mutations on the stability of a cyclohexanone monooxygenase.
Topics: Acinetobacter; Bacterial Proteins; Cysteine; Disulfides; Enzyme Stability; Escherichia coli; Mutation; Oxygenases; Protein Engineering; Recombinant Proteins; Serine | 2015 |
Regulation of the unfolded protein response via S-nitrosylation of sensors of endoplasmic reticulum stress.
Topics: Amino Acid Substitution; Animals; Cell Death; Cell Line; Cell Line, Tumor; Cysteine; eIF-2 Kinase; Endoplasmic Reticulum; Endoplasmic Reticulum Stress; Endoribonucleases; Eukaryotic Initiation Factor-2; Fibroblasts; Mice; Models, Biological; Mutagenesis, Site-Directed; Neurons; Nitric Oxide; Parkinson Disease; Phosphorylation; Protein Processing, Post-Translational; Protein Serine-Threonine Kinases; Serine; Signal Transduction; Unfolded Protein Response | 2015 |
An Unprecedented Combination of Serine and Cysteine Nucleophiles in a Split Intein with an Atypical Split Site.
Topics: Cysteine; Databases, Nucleic Acid; Inteins; Metagenome; Point Mutation; Serine | 2015 |
The Characteristics and Regulatory Mechanisms of Superoxide Generation from eNOS Reductase Domain.
Topics: Animals; Biopterins; Calmodulin; Cattle; Cysteine; Electron Spin Resonance Spectroscopy; Heme; Mutation; Nitric Oxide Synthase Type III; Oxidation-Reduction; Phosphorylation; Protein Structure, Tertiary; Serine; Superoxides | 2015 |
The role of protein disulfide isomerase in the post-ligation phase of β3 integrin-dependent cell adhesion.
Topics: Animals; Bacitracin; Catalysis; Cell Adhesion; Cell Line; Cricetinae; Cysteine; Disulfides; Fibrinogen; Flow Cytometry; Humans; Integrin alphaVbeta3; Integrin beta3; Ligands; Mutation; Platelet Glycoprotein GPIIb-IIIa Complex; Protein Disulfide-Isomerases; Protein Domains; Serine | 2015 |
Evolutionary Loss of Activity in De-Ubiquitylating Enzymes of the OTU Family.
Topics: Amino Acid Sequence; Amino Acid Substitution; Animals; Apoptosis; Binding Sites; Catalytic Domain; Conserved Sequence; Cysteine; Drosophila melanogaster; Drosophila Proteins; Evolution, Molecular; Gene Expression Regulation; Humans; Inhibitor of Apoptosis Proteins; Molecular Sequence Data; Protein Binding; RNA, Small Interfering; Sequence Alignment; Sequence Homology, Amino Acid; Serine; Ubiquitin; Ubiquitin-Specific Proteases; Ubiquitination | 2015 |
Conformational Interconversions of Amino Acid Derivatives.
Topics: Alanine; Amino Acids; Cysteine; Models, Molecular; Molecular Conformation; Quantum Theory; Serine; Thermodynamics | 2016 |
Chemoselectivity and the Chan-Lam Coupling Reaction: Adding Amino Acids to Polymer-Coated Microelectrode Arrays.
Topics: Amino Acids; Cysteine; Microelectrodes; Peptides; Polymers; Serine | 2016 |
Changes in one-carbon metabolism after duodenal-jejunal bypass surgery.
Topics: Adenosine Diphosphate; Adenosine Monophosphate; Adenosine Triphosphate; Aldehyde Dehydrogenase; AMP-Activated Protein Kinases; Anastomosis, Surgical; Animals; Bariatric Surgery; Betaine-Homocysteine S-Methyltransferase; Blood Glucose; Cystathionine; Cystathionine beta-Synthase; Cysteine; Duodenum; Fatty Acids; Gastric Bypass; Glucose; Glutathione; Glutathione Transferase; Guanine Deaminase; Hypoxanthine; Inosine Monophosphate; Jejunum; Liver; Male; Metabolomics; Obesity; Oxidation-Reduction; Phosphorylation; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Serine; Vitamin B 12 | 2016 |
Cysteine biosynthesis in Lactobacillus casei: identification and characterization of a serine acetyltransferase.
Topics: Acetyl Coenzyme A; Cloning, Molecular; Culture Media; Cysteine; Cysteine Synthase; DNA, Bacterial; Escherichia coli; Lacticaseibacillus casei; Molecular Sequence Annotation; Mutation; Plasmids; Recombinant Proteins; Serine; Serine O-Acetyltransferase; Sulfur | 2016 |
Cytotoxicity studies of water soluble coordination compounds with a [Mo2O2S2](2+) core.
Topics: Antineoplastic Agents; Cell Line, Tumor; Cell Survival; Cisplatin; Coordination Complexes; Cysteine; HT29 Cells; Humans; Inhibitory Concentration 50; Ligands; MCF-7 Cells; Metals, Alkali; Molybdenum; Organometallic Compounds; Serine; Solubility; Structure-Activity Relationship; Sulfur; Threonine; Water | 2016 |
A unified mechanism for proteolysis and autocatalytic activation in the 20S proteasome.
Topics: Aspartic Acid; Autolysis; Catalysis; Catalytic Domain; Crystallography, X-Ray; Cysteine; Lysine; Mutagenesis, Site-Directed; Proteasome Endopeptidase Complex; Protein Precursors; Proteolysis; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Serine; Threonine | 2016 |
Identification of Connexin43 Phosphorylation and S-Nitrosylation in Cultured Primary Vascular Cells.
Topics: Biotin; Blotting, Western; Cells, Cultured; Connexin 43; Cysteine; Fluorescent Antibody Technique; Human Umbilical Vein Endothelial Cells; Humans; Phosphorylation; Primary Cell Culture; Protein Processing, Post-Translational; S-Nitrosothiols; Serine; Threonine; Tyrosine | 2016 |
Nitrile-synthesizing enzyme: Screening, purification and characterization.
Topics: Alanine; Culture Media; Cyanides; Cysteine; Hydrogen-Ion Concentration; Kinetics; Lyases; Molecular Weight; Nitriles; Pseudomonas; Serine; Serine O-Acetyltransferase; Substrate Specificity; Temperature | 2016 |
A novel Na(+) -Independent alanine-serine-cysteine transporter 1 inhibitor inhibits both influx and efflux of D-Serine.
Topics: Amino Acid Transport System ASC; Animals; Cells, Cultured; CHO Cells; Cobamides; Cricetulus; Cyclohexanes; Cysteine; Dose-Response Relationship, Drug; Embryo, Mammalian; Hippocampus; Male; Microdialysis; Minor Histocompatibility Antigens; Neurons; Organophosphonates; Rats; Rats, Sprague-Dawley; Rats, Wistar; Serine; Sodium | 2016 |
Identification of SER-PRO-CYS Peptide in Blood Serum of Multiple Sclerosis Patients.
Topics: Adult; Amino Acid Sequence; Biomarkers; Cysteine; Female; Humans; Male; Middle Aged; Multiple Sclerosis; Peptides; Proline; Serine; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Tandem Mass Spectrometry; Young Adult | 2016 |
Paracrine effect of carbon monoxide - astrocytes promote neuroprotection through purinergic signaling in mice.
Topics: Adenosine; Adenosine Triphosphate; Animals; Apoptosis; Astrocytes; Carbon Monoxide; Coculture Techniques; Cysteine; Extracellular Space; Gene Silencing; Glycyrrhetinic Acid; Mice, Inbred C57BL; Models, Biological; Neurons; Neuroprotection; Paracrine Communication; Pyrimidines; Receptor, trkB; Receptors, Adenosine A2; Receptors, Purinergic; Serine; Signal Transduction; Suramin; Thioinosine; Triazoles; Xanthines | 2016 |
Approaches to Determine Protein Ubiquitination Residue Types.
Topics: Amino Acid Sequence; Cysteine; Methionine; Molecular Biology; Protein Processing, Post-Translational; Proteins; Serine; Ubiquitin; Ubiquitination | 2016 |
Enabling N-to-C Ser/Thr Ligation for Convergent Protein Synthesis via Combining Chemical Ligation Approaches.
Topics: Amino Acid Sequence; Carbon; Chemistry Techniques, Synthetic; Cysteine; Interleukin-17; Nitrogen; Oligopeptides; Proteins; Serine | 2016 |
Differential 3-bromopyruvate inhibition of cytosolic and mitochondrial human serine hydroxymethyltransferase isoforms, key enzymes in cancer metabolic reprogramming.
Topics: Amino Acid Sequence; Antineoplastic Agents; Catalytic Domain; Cloning, Molecular; Cysteine; Cytosol; Enzyme Assays; Escherichia coli; Gene Expression; Glycine Hydroxymethyltransferase; Humans; Kinetics; Mitochondria; Molecular Docking Simulation; Mutagenesis, Site-Directed; Protein Binding; Protein Domains; Protein Structure, Secondary; Pyruvates; Recombinant Proteins; Serine; Structure-Activity Relationship | 2016 |
Association between Type A blaZ Gene Polymorphism and Cefazolin Inoculum Effect in Methicillin-Susceptible Staphylococcus aureus.
Topics: Anti-Bacterial Agents; Bacterial Proteins; Cefazolin; Cysteine; Dipeptides; Humans; Methicillin; Microbial Sensitivity Tests; Phylogeny; Polymorphism, Single Nucleotide; Serine; Staphylococcus aureus | 2016 |
Control of Autophagy in Chlamydomonas Is Mediated through Redox-Dependent Inactivation of the ATG4 Protease.
Topics: Autophagy; Chlamydomonas; Conserved Sequence; Cysteine; Disulfides; Enzyme Activation; Light; Models, Biological; Mutation; NADP; Oxidation-Reduction; Plant Proteins; Protein Aggregates; Protein Multimerization; Serine; Stress, Physiological; Structure-Activity Relationship; Thioredoxins | 2016 |
An archaeal ADP-dependent serine kinase involved in cysteine biosynthesis and serine metabolism.
Topics: Archaeal Proteins; Cysteine; Gene Expression Regulation, Archaeal; Gene Expression Regulation, Enzymologic; Glycine; Protein Serine-Threonine Kinases; Serine; Thermococcus; Threonine | 2016 |
Mutational analysis of Kex2 recognition sites and a disulfide bond in tannase from Aspergillus oryzae.
Topics: Aspergillus oryzae; Binding Sites; Carboxylic Ester Hydrolases; Catalysis; Crystallography, X-Ray; Cysteine; Disulfides; DNA Mutational Analysis; Fungal Proteins; Gene Deletion; Genetic Variation; Glycoside Hydrolases; Histidine; Hydrogen-Ion Concentration; Proprotein Convertases; Serine; Substrate Specificity; Temperature | 2017 |
An ENU-induced p.C225S missense mutation in the mouse Tgfb1 gene does not cause Camurati-Engelmann disease-like skeletal phenotypes.
Topics: Amino Acid Substitution; Animals; Camurati-Engelmann Syndrome; Cysteine; Ethylnitrosourea; Female; Gene Library; Genetic Association Studies; HEK293 Cells; Humans; Male; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Molecular Targeted Therapy; Mutation, Missense; Phenotype; Serine; Signal Transduction; Transforming Growth Factor beta1 | 2017 |
Cysteine 893 is a target of regulatory thiol modifications of GluA1 AMPA receptors.
Topics: Adaptor Proteins, Signal Transducing; Amino Acid Substitution; Catalytic Domain; Cysteine; Discs Large Homolog 1 Protein; HEK293 Cells; Humans; Membrane Proteins; Nitric Oxide Synthase Type I; Receptors, AMPA; Serine | 2017 |
RIP1 autophosphorylation is promoted by mitochondrial ROS and is essential for RIP3 recruitment into necrosome.
Topics: Animals; Apoptosis; Cell Line, Tumor; Cysteine; Humans; Mice; Mitochondria; Necrosis; NIH 3T3 Cells; Phosphorylation; Primary Cell Culture; Reactive Oxygen Species; Receptor-Interacting Protein Serine-Threonine Kinases; Serine; Tumor Necrosis Factor-alpha | 2017 |
Novel synthetic analogues of avian β-defensin-12: the role of charge, hydrophobicity, and disulfide bridges in biological functions.
Topics: Alanine; Amino Acid Sequence; Animals; Anti-Infective Agents; Bacteria; Bacterial Load; beta-Defensins; Birds; Cell Line; Chemotaxis; Chickens; Colony Count, Microbial; Cysteine; Dendritic Cells; Disulfides; Drug Combinations; Hydrophobic and Hydrophilic Interactions; Macrophages; Microbial Sensitivity Tests; Microscopy, Electron, Scanning; Peptides; Protein Conformation; Serine; Sodium Chloride | 2017 |
Ganoderic acid targeting nuclear factor erythroid 2-related factor 2 in lung cancer.
Topics: Cell Line, Tumor; Cell Movement; Cell Proliferation; Cell Survival; Cysteine; Humans; Lung Neoplasms; Molecular Docking Simulation; NF-E2-Related Factor 2; Protein Conformation; Protein Isoforms; Reactive Oxygen Species; Serine; Signal Transduction; Triterpenes | 2017 |
Crystal Structure of the Regulatory Domain of AphB from
Topics: Bacterial Proteins; Benzene Derivatives; Binding Sites; Crystallography, X-Ray; Cysteine; Gene Expression Regulation, Bacterial; Genes, Regulator; Hydrogen-Ion Concentration; Ligands; Models, Molecular; Oxidative Stress; Protein Interaction Domains and Motifs; Sequence Analysis, Protein; Serine; Trans-Activators; Vibrio Infections; Vibrio vulnificus; Virulence | 2017 |
Overexpression of Ebola virus envelope GP1 protein.
Topics: Amino Acid Substitution; Base Pairing; Cell Adhesion Molecules; Cloning, Molecular; Codon, Initiator; Cysteine; Ebolavirus; Gene Expression; Genetic Vectors; HEK293 Cells; Humans; Lectins, C-Type; Nucleic Acid Conformation; Protein Binding; Protein Biosynthesis; Receptors, Cell Surface; Recombinant Proteins; Serine; Viral Envelope Proteins | 2017 |
Cysteine Biosynthesis Controls Serratia marcescens Phospholipase Activity.
Topics: Culture Media; Cysteine; DNA Transposable Elements; Gene Expression Profiling; Gene Knockout Techniques; Genetic Complementation Test; Locomotion; Mutagenesis, Insertional; Phospholipases; Serine; Serine O-Acetyltransferase; Serratia marcescens | 2017 |
Mutations to Cysteine Residues in the Trypanosoma cruzi B-Cell Superantigen Tc24 Diminish Susceptibility to IgM-Mediated Hydrolysis.
Topics: Animals; Antibodies, Protozoan; B-Lymphocytes; Calcium-Binding Proteins; Chagas Disease; Cysteine; Hydrolysis; Immunity, Innate; Immunization; Immunoglobulin M; Mice; Mutation; Protein Isoforms; Protozoan Vaccines; Sequence Alignment; Serine; Superantigens; Trypanosoma cruzi | 2017 |
mTORC2 Regulates Amino Acid Metabolism in Cancer by Phosphorylation of the Cystine-Glutamate Antiporter xCT.
Topics: A549 Cells; Amino Acid Transport System y+; Brain Neoplasms; Cysteine; Glioblastoma; Glutamine; Glutathione; HEK293 Cells; Humans; Mechanistic Target of Rapamycin Complex 1; Multiprotein Complexes; Mutation; Phosphorylation; Protein Binding; Proteomics; RNA Interference; Serine; Tandem Mass Spectrometry; Time Factors; TOR Serine-Threonine Kinases; Transfection; Tumor Microenvironment | 2017 |
Structural basis of the substrate specificity and instability in solution of a glycosidase from Lactobacillus plantarum.
Topics: Catalytic Domain; Cysteine; Glucosidases; Glycoside Hydrolases; Lactobacillus plantarum; Phosphates; Proteolysis; Serine; Solubility; Solutions; Substrate Specificity | 2017 |
Improved fermentative L-cysteine overproduction by enhancing a newly identified thiosulfate assimilation pathway in Escherichia coli.
Topics: Biosynthetic Pathways; Cysteine; Escherichia coli; Escherichia coli Proteins; Fermentation; Genetic Engineering; Glucose; Glycerol; Serine; Sulfates; Sulfides; Sulfites; Sulfur; Thiosulfate Sulfurtransferase; Thiosulfates | 2017 |
Biogenesis of Hydrogen Sulfide and Thioethers by Cystathionine Beta-Synthase.
Topics: Alanine; Animals; Biomarkers; Catalysis; Cystathionine beta-Synthase; Cysteine; Haplorhini; Homocysteine; Hydrogen Sulfide; Kinetics; Mice; Mice, Knockout; Serine; Sulfides; Sulfur | 2018 |
Anaerobic sulfatase maturase AslB from Escherichia coli activates human recombinant iduronate-2-sulfate sulfatase (IDS) and N-acetylgalactosamine-6-sulfate sulfatase (GALNS).
Topics: Catalytic Domain; Chondroitinsulfatases; Cysteine; Enzyme Activation; Escherichia coli; Escherichia coli Proteins; Glycoproteins; Humans; Models, Molecular; Molecular Docking Simulation; Molecular Dynamics Simulation; Protein Binding; Recombinant Proteins; Serine; Sulfatases | 2017 |
Biochemical characterization of argininosuccinate lyase from M. tuberculosis: significance of a c-terminal cysteine in catalysis and thermal stability.
Topics: Amino Acid Sequence; Arginine; Argininosuccinate Lyase; Argininosuccinic Acid; Bacterial Proteins; Binding Sites; Biocatalysis; Cloning, Molecular; Cysteine; Enzyme Stability; Escherichia coli; Gene Expression; Genetic Vectors; Kinetics; Mutagenesis, Site-Directed; Mycobacterium tuberculosis; Protein Binding; Protein Structure, Secondary; Recombinant Proteins; Sequence Alignment; Sequence Homology, Amino Acid; Serine; Structure-Activity Relationship; Substrate Specificity | 2017 |
Arsenic methylation by a novel ArsM As(III) S-adenosylmethionine methyltransferase that requires only two conserved cysteine residues.
Topics: Amino Acid Sequence; Animals; Arsenic; Arsenites; Bacillus; Base Sequence; Conserved Sequence; Cysteine; Humans; Methylation; Methyltransferases; Mutagenesis, Site-Directed; Serine | 2018 |
Novel biosynthetic pathway for sulfur amino acids in Cryptococcus neoformans.
Topics: Agrobacterium tumefaciens; Amino Acids, Sulfur; Animals; Cryptococcus neoformans; Cysteine; Cysteine Synthase; Genome, Fungal; Hydrogen Sulfide; Male; Methionine; Mice, Inbred ICR; Models, Animal; Mutagenesis; Saccharomyces cerevisiae; Serine; Sulfur; Virulence | 2018 |
Reconstruction of cysteine biosynthesis using engineered cysteine-free enzymes.
Topics: Cloning, Molecular; Cysteine; Cysteine Synthase; Escherichia coli; Methionine; Serine; Serine O-Acetyltransferase; Sulfur | 2018 |
Activity-based E3 ligase profiling uncovers an E3 ligase with esterification activity.
Topics: Adaptor Proteins, Signal Transducing; Biocatalysis; Cell Line, Tumor; Crystallography, X-Ray; Cysteine; Esterification; HEK293 Cells; Humans; Lysine; Models, Molecular; Protein Domains; Proteomics; Serine; Substrate Specificity; Threonine; Ubiquitin; Ubiquitin-Protein Ligases; Ubiquitination | 2018 |
The second and third amino acids of Pam2 lipopeptides are key for the proliferation of cytotoxic T cells.
Topics: Adjuvants, Immunologic; Animals; Antigen Presentation; Cell Differentiation; Cell Proliferation; Cells, Cultured; Cysteine; Dendritic Cells; Interferon-gamma; Lipopeptides; Lymphocyte Activation; Mice; Mice, Inbred C57BL; Mice, Knockout; Myeloid Differentiation Factor 88; Peptide Library; Protein Conformation; Serine; Staphylococcus aureus; T-Lymphocytes, Cytotoxic; Toll-Like Receptor 2 | 2018 |
Quantification of thioether-linked glutathione modifications in human lens proteins.
Topics: Adolescent; Alanine; Aminobutyrates; Cataract; Cellular Senescence; Chromatography, Liquid; Crystallins; Cysteine; Glutathione; Humans; Lens, Crystalline; Middle Aged; Protein Processing, Post-Translational; Serine; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Sulfides; Threonine; Tissue Donors; Young Adult | 2018 |
Prediction of Rare Palmitoylation Events in Proteins.
Topics: Algorithms; Cysteine; Glycine; Humans; Lipoylation; Palmitic Acid; Position-Specific Scoring Matrices; Protein Processing, Post-Translational; Proteins; Proteome; Serine; Support Vector Machine | 2018 |
PDI-mediated S-nitrosylation of DRP1 facilitates DRP1-S616 phosphorylation and mitochondrial fission in CA1 neurons.
Topics: Animals; Cysteine; Disease Models, Animal; Dynamins; Male; Mitochondria; Mitochondrial Dynamics; Neurons; NG-Nitroarginine Methyl Ester; Nitric Oxide; Phosphorylation; Protein Disulfide-Isomerases; Proteolysis; Rats; Rats, Sprague-Dawley; Serine; Status Epilepticus | 2018 |
Crystal structure of Arabidopsis thaliana peroxiredoxin A C119S mutant.
Topics: Amino Acid Sequence; Amino Acid Substitution; Arabidopsis; Arabidopsis Proteins; Catalytic Domain; Chloroplast Proteins; Chloroplasts; Cloning, Molecular; Crystallography, X-Ray; Cysteine; Escherichia coli; Gene Expression; Genetic Vectors; Kinetics; Models, Molecular; Mutation; Peroxiredoxins; Protein Binding; Protein Conformation, alpha-Helical; Protein Conformation, beta-Strand; Protein Interaction Domains and Motifs; Protein Multimerization; Recombinant Proteins; Serine; Substrate Specificity | 2018 |
Molecular and biochemical characterization of key enzymes in the cysteine and serine metabolic pathways of Acanthamoeba castellanii.
Topics: Acanthamoeba castellanii; Animals; Bacterial Proteins; Cloning, Molecular; Cysteine; Cysteine Synthase; Drug Delivery Systems; Escherichia coli; Gene Expression Regulation, Enzymologic; Glycolysis; Metabolic Networks and Pathways; Mice; Microscopy, Confocal; Phosphoglycerate Dehydrogenase; Real-Time Polymerase Chain Reaction; Recombinant Proteins; Serine; Sugar Alcohol Dehydrogenases; Transaminases | 2018 |
Trapping biosynthetic acyl-enzyme intermediates with encoded 2,3-diaminopropionic acid.
Topics: beta-Alanine; Biocatalysis; Biosynthetic Pathways; Cysteine; Cysteine Proteases; Escherichia coli; Models, Molecular; Peptides; Protein Domains; Recombinant Proteins; Serine; Substrate Specificity; Thiolester Hydrolases; Valinomycin | 2019 |
Enzymatic assembly of carbon-carbon bonds via iron-catalysed sp
Topics: Alkylation; Animals; Biocatalysis; Carbon; Coenzymes; Cysteine; Cytochrome P-450 Enzyme System; Directed Molecular Evolution; Heme; Hydrogen; Iron; Male; Methane; Serine; Substrate Specificity; Vitamin B 12 | 2019 |
L-cysteine/cystathionine-β-synthase-induced relaxation in mouse aorta involves a L-serine/sphingosine-1-phosphate/NO pathway.
Topics: Animals; Aorta; Cystathionine; Cystathionine beta-Synthase; Cysteine; Humans; Lysophospholipids; Mice; Serine; Sphingosine | 2020 |
Serum Metabolomics Study of Nonsmoking Female Patients with Non-Small Cell Lung Cancer Using Gas Chromatography-Mass Spectrometry.
Topics: Adult; Aged; Amino Acids; Biomarkers, Tumor; Carcinoma, Non-Small-Cell Lung; Case-Control Studies; Cysteine; Diagnosis, Differential; Diglycerides; Early Detection of Cancer; Energy Metabolism; Female; Gas Chromatography-Mass Spectrometry; Humans; Lipid Metabolism; Lung Neoplasms; Metabolome; Middle Aged; Neoplasms; Non-Smokers; Oxidative Stress; Sensitivity and Specificity; Serine | 2019 |
Mutations of Cys and Ser residues in the α5-subunit of the 20S proteasome from Saccharomyces cerevisiae affects gating and chronological lifespan.
Topics: Cysteine; Glutathione; Longevity; Mutation; Oxidative Stress; Proteasome Endopeptidase Complex; Proteolysis; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Serine | 2019 |
Characterising covalent warhead reactivity.
Topics: Amino Acids; Cysteine; Kinetics; Magnetic Resonance Spectroscopy; Pharmaceutical Preparations; Serine | 2019 |
Deciphering S-methylcysteine biosynthesis in common bean by isotopic tracking with mass spectrometry.
Topics: Biosynthetic Pathways; Carbon Isotopes; Carbon-Sulfur Lyases; Chromatography, Reverse-Phase; Cysteine; Cysteine Synthase; Mass Spectrometry; Metabolomics; Methionine; Nitrogen Isotopes; Phaseolus; Seeds; Serine; Sulfur | 2019 |
Synthetic Access to 3-Substituted Pyroglutamic Acids from Tetramate Derivatives of Serine, Threonine,
Topics: Cysteine; Molecular Conformation; Pyrrolidonecarboxylic Acid; Serine; Stereoisomerism; Threonine | 2019 |
Highly efficient preparation of active S-phenyl-L-cysteine with tryptophan synthase using a chemoenzymatic method.
Topics: Bromobenzenes; Chemistry, Organic; Cysteine; Magnesium; Models, Chemical; Molecular Structure; Organometallic Compounds; Phenols; Serine; Sulfhydryl Compounds; Tryptophan Synthase | 2019 |
Unraveling the Impact of Cysteine-to-Serine Mutations on the Structural and Functional Properties of Cu(I)-Binding Proteins.
Topics: Amino Acid Substitution; Copper-Transporting ATPases; Cysteine; Humans; Metallochaperones; Models, Molecular; Mutant Proteins; Mutation; Protein Conformation; Serine; Spectrum Analysis; Structure-Activity Relationship | 2019 |
Mechanistic and Structural Insights into Cysteine-Mediated Inhibition of Pyruvate Kinase Muscle Isoform 2.
Topics: Amino Acid Substitution; Amino Acids; Carrier Proteins; Catalysis; Catalytic Domain; Crystallography, X-Ray; Cysteine; Enzyme Inhibitors; Humans; Isoenzymes; Ligands; Membrane Proteins; Models, Molecular; Mutant Proteins; Phosphoenolpyruvate; Protein Binding; Protein Conformation; Serine; Thyroid Hormone-Binding Proteins; Thyroid Hormones; Tyrosine | 2019 |
Efficient production of glutathione with multi-pathway engineering in Corynebacterium glutamicum.
Topics: Corynebacterium glutamicum; Cysteine; Glutamic Acid; Glutathione; Glycine; Metabolic Engineering; Metabolic Networks and Pathways; Serine | 2019 |
Mining for protein S-sulfenylation in
Topics: Arabidopsis; Catalytic Domain; Cysteine; Humans; Hydrogen Peroxide; Mitogen-Activated Protein Kinase 1; Oxidation-Reduction; Proteins; RNA; Serine; Signal Transduction; Sulfenic Acids; Sulfhydryl Compounds | 2019 |
Combined genome editing and transcriptional repression for metabolic pathway engineering in Corynebacterium glutamicum using a catalytically active Cas12a.
Topics: Bacterial Proteins; Bioreactors; Corynebacterium glutamicum; CRISPR-Associated Proteins; CRISPR-Cas Systems; Cysteine; Endodeoxyribonucleases; Gene Deletion; Gene Editing; Genome, Bacterial; Metabolic Engineering; Metabolic Networks and Pathways; RNA, Guide, Kinetoplastida; Serine | 2019 |
Transsulfuration Activity Can Support Cell Growth upon Extracellular Cysteine Limitation.
Topics: A549 Cells; Animals; Cell Proliferation; Cysteine; Extracellular Space; Female; Gene Knockout Techniques; Hep G2 Cells; Heterografts; Humans; Male; MCF-7 Cells; Methionine; Mice; Mice, Inbred NOD; Mice, Nude; Mice, SCID; Neoplasms; Protamines; S-Adenosylhomocysteine; S-Adenosylmethionine; Serine; Tumor Burden | 2019 |
Hepatitis C Virus RNA-Dependent RNA Polymerase Is Regulated by Cysteine S-Glutathionylation.
Topics: Amino Acid Substitution; Cell Line, Tumor; Cysteine; Genome, Viral; Glutathione; Hepacivirus; Humans; Oxidation-Reduction; Recombinant Proteins; Replicon; RNA-Dependent RNA Polymerase; RNA, Viral; Serine; Viral Nonstructural Proteins; Virus Replication | 2019 |
Syntheses of Atypically Fluorinated Peptidyl Macrocycles through Sequential Vinylic Substitutions.
Topics: Cysteine; Histidine; Humans; Macrocyclic Compounds; Peptides; Serine; Tyrosine; Vinyl Compounds | 2020 |
Serotonin 5-HT
Topics: Calcium; Cell Membrane; Cysteine; Humans; In Vitro Techniques; Polymorphism, Single Nucleotide; Receptor, Serotonin, 5-HT2C; Serine; Serotonin; Serotonin Receptor Agonists | 2019 |
Impact of naturally occurring serine/cysteine variations on the structure and function of Pseudomonas metallothioneins.
Topics: Amino Acid Sequence; Bacterial Proteins; Cysteine; Edetic Acid; Magnetic Resonance Spectroscopy; Mass Spectrometry; Metallothionein; Pseudomonas; Serine | 2020 |
Keap1 Cystenine 151 as a Potential Target for Artemisitene-Induced Nrf2 Activation.
Topics: A549 Cells; Amino Acid Substitution; Artemisinins; Cysteine; Humans; Kelch-Like ECH-Associated Protein 1; Mutant Proteins; NF-E2-Related Factor 2; Oxidation-Reduction; Serine; Transcriptional Activation; Ubiquitination | 2019 |
De novo formation of citrate-based fluorophores on N-termini of peptides and proteins in cells and tissues.
Topics: Animals; Cell Line, Tumor; Citric Acid; Cysteine; Fluorescence; Fluorescent Dyes; HEK293 Cells; Humans; Mice; Microscopy, Confocal; Microscopy, Fluorescence; Molecular Probes; NIH 3T3 Cells; Peptides; Proof of Concept Study; Proteins; Pyridones; Serine; Thiazoles | 2020 |
Accelerated transsulfuration metabolically defines a discrete subclass of amyotrophic lateral sclerosis patients.
Topics: Aged; Amyotrophic Lateral Sclerosis; Case-Control Studies; Cells, Cultured; Cysteine; Female; Fibroblasts; Glucose; Glutathione; Humans; Male; Metabolic Networks and Pathways; Metabolome; Metabolomics; Middle Aged; Serine; Skin | 2020 |
Cystathionine β-synthase is involved in cysteine biosynthesis and H
Topics: Biocatalysis; Cystathionine; Cystathionine beta-Synthase; Cystathionine gamma-Lyase; Cysteine; DNA, Complementary; Genes, Protozoan; Heme; Homocysteine; Hydrogen Sulfide; Kinetics; Serine; Toxoplasma | 2020 |
An intraresidue H-bonding motif in selenocysteine and cysteine, revealed by gas phase laser spectroscopy and quantum chemistry calculations.
Topics: Cysteine; Dipeptides; Hydrogen Bonding; Protein Structure, Secondary; Quantum Theory; Selenocysteine; Serine; Spectrum Analysis | 2020 |
Prebiotic synthesis of cysteine peptides that catalyze peptide ligation in neutral water.
Topics: Alanine; Catalysis; Cysteine; Kinetics; Nitriles; Origin of Life; Peptides; Serine | 2020 |
Cystathionine-gamma-lyase overexpression in T cells enhances antitumor effect independently of cysteine autonomy.
Topics: Adoptive Transfer; Animals; CD8-Positive T-Lymphocytes; Cell Engineering; Cell Line, Tumor; Cell Proliferation; Cystathionine gamma-Lyase; Cysteine; Extracellular Fluid; Female; Glycine; Methionine; Mice; Mice, Inbred C57BL; Models, Animal; Ovarian Neoplasms; Proline; Serine; Tumor Microenvironment | 2021 |
Role of a cysteine residue in substrate entry and catalysis in MtHIBADH: Analysis by chemical modifications and site-directed mutagenesis.
Topics: Alanine; Alcohol Oxidoreductases; Bacterial Proteins; Catalysis; Cysteine; Dinitrobenzenes; Hydrogen Bonding; Models, Molecular; Mutagenesis, Site-Directed; Mycobacterium tuberculosis; NAD; p-Chloromercuribenzoic Acid; Protein Conformation; Recombinant Proteins; Serine; Structure-Activity Relationship; Substrate Specificity | 2021 |
Difference in an intermolecular disulfide-bond between two highly homologous serum proteins Leg1a and Leg1b implicates their functional differentiation.
Topics: Animals; Blood Proteins; Cysteine; Disulfides; Gene Expression Regulation; Liver; Male; Mutagenesis, Site-Directed; Oxygen; Principal Component Analysis; Protein Conformation; Serine; Up-Regulation; Zebrafish; Zebrafish Proteins | 2021 |
Serine acetyltransferase from Neisseria gonorrhoeae; structural and biochemical basis of inhibition.
Topics: Acetyl Coenzyme A; Amino Acid Sequence; Biocatalysis; Catalytic Domain; Cloning, Molecular; Crystallization; Crystallography, X-Ray; Cysteine; Escherichia coli; Feedback, Physiological; Kinetics; Ligands; Malates; Neisseria gonorrhoeae; Protein Binding; Protein Conformation, alpha-Helical; Protein Conformation, beta-Strand; Serine; Serine O-Acetyltransferase | 2022 |
Influence of cysteine, serine, sulfate, and sulfide on anaerobic conversion of unsaturated long-chain fatty acid, oleate, to methane.
Topics: Anaerobiosis; Bioreactors; Cysteine; Fatty Acids; Methane; Oleic Acid; RNA, Ribosomal, 16S; Serine; Sulfates; Sulfides | 2022 |
Plasma Metabolomic Changes in Children with Cerebral Palsy Exposed to Botulinum Neurotoxin.
Topics: Botulinum Toxins, Type A; Cerebral Palsy; Child; Cysteine; Glycine; Humans; Injections, Intramuscular; Methionine; Muscle Spasticity; Neuromuscular Agents; Serine; Threonine; Treatment Outcome | 2022 |
Structural analysis of cysteine-free Nt.BspD6 nicking endonuclease and its functional features.
Topics: Bacillus; Binding Sites; Crystallography, X-Ray; Cysteine; Deoxyribonuclease I; Dimerization; DNA; Endonucleases; Hydrogen Bonding; Hydrolysis; Molecular Structure; Mutagenesis, Site-Directed; Protein Subunits; Serine | 2022 |
Active O-acetylserine-(thiol) lyase A and B confer improved selenium resistance and degrade l-Cys and l-SeCys in Arabidopsis.
Topics: Arabidopsis; Carbon-Oxygen Lyases; Cysteine; Lyases; Selenic Acid; Selenium; Serine; Sulfhydryl Compounds; Sulfites; Sulfur | 2022 |
Introducing Cysteines into Nanobodies for Site-Specific Labeling.
Topics: Cysteine; Fluoresceins; Serine; Single-Domain Antibodies; Sulfonic Acids | 2022 |
Global profiling of phosphorylation-dependent changes in cysteine reactivity.
Topics: Cysteine; Humans; Phosphorylation; Protein Processing, Post-Translational; Proteome; Proteomics; Serine; Threonine | 2022 |
Targeting ASCT2-mediated glutamine metabolism inhibits proliferation and promotes apoptosis of pancreatic cancer cells.
Topics: Adenosine Triphosphate; Alanine; Amino Acid Transport System ASC; Apoptosis; Cell Line, Tumor; Cell Proliferation; Cysteine; Glutamine; Humans; Minor Histocompatibility Antigens; Pancreas; Pancreatic Neoplasms; Reactive Oxygen Species; Serine | 2022 |
A cell wall-anchored glycoprotein confers resistance to cation stress in Actinomyces oris biofilms.
Topics: Actinomyces; Bacterial Proteins; Biofilms; Cations, Divalent; Cell Wall; Cysteine; Detergents; Membrane Proteins; Peptidoglycan; Peptidyl Transferases; Serine; Sodium Dodecyl Sulfate | 2022 |
Genomic Insights into the Distribution of Peptidases and Proteolytic Capacity among
Topics: Animals; Bacteria; Cysteine; Genomics; Peptide Hydrolases; Phylogeny; Prevotella; Proteolysis; RNA, Ribosomal, 16S; Ruminants; Serine | 2022 |
The association of serum sulfur amino acids and related metabolites with incident diabetes: a prospective cohort study.
Topics: Amino Acids; Amino Acids, Sulfur; Cystathionine; Cysteine; Diabetes Mellitus; Glutamates; Glutamine; Humans; Methionine; Prospective Studies; Serine; Taurine | 2022 |
Serine and Cysteine Peptidases: So Similar, Yet Different. How the Active-Site Electrostatics Facilitates Different Reaction Mechanisms.
Topics: Catalysis; Catalytic Domain; Cysteine; Oxygen; Serine; Serine Endopeptidases; Static Electricity | 2022 |
Serine/Threonine Ligation and Cysteine/Penicillamine Ligation.
Topics: Cysteine; Esters; Penicillamine; Peptides; Serine; Threonine | 2022 |
Surface cysteine to serine substitutions in IL-18 reduce aggregation and enhance activity.
Topics: Cysteine; Escherichia coli; Humans; Interferon-gamma; Interleukin-18; Recombinant Proteins; Renal Dialysis; Serine | 2022 |
Structural and functional studies of serine acetyltransferase isoform from Entamoeba histolytica reveals novel role of the C-terminal tail in loss of regulation from feedback inhibition.
Topics: Cysteine; Entamoeba histolytica; Feedback; Protein Isoforms; Serine; Serine O-Acetyltransferase | 2022 |
H
Topics: Aminooxyacetic Acid; Cystathionine beta-Synthase; Cysteine; Humans; Hydrogen Sulfide; Serine | 2022 |
Chemical acylation of an acquired serine suppresses oncogenic signaling of K-Ras(G12S).
Topics: Acylation; Cysteine; Humans; Mutation; Oncogenes; Proto-Oncogene Proteins p21(ras); Serine | 2022 |
Metabolic engineering of the L-serine biosynthetic pathway improves glutathione production in Saccharomyces cerevisiae.
Topics: Biosynthetic Pathways; Cysteine; Fermentation; Glutathione; Metabolic Engineering; Phosphoglycerate Dehydrogenase; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Serine | 2022 |
The Nϵ-Rule for Serine, but Not Cysteine Catalytic Triads.
Topics: Binding Sites; Cysteine; Histidine; Imidazoles; Models, Molecular; Protons; Serine | 2022 |
Cysteine Oxidation to Sulfenic Acid in APE1 Aids G-Quadruplex Binding While Compromising DNA Repair.
Topics: Cysteine; DNA Repair; DNA-(Apurinic or Apyrimidinic Site) Lyase; Endonucleases; Serine; Sulfenic Acids; Transcription Factors | 2022 |
Rapid, sensitive analysis method for determining the nitrogen stable isotope ratio of total free amino acids in soil.
Topics: Alanine; Amino Acids; Arginine; Asparagine; Aspartic Acid; Cysteine; gamma-Aminobutyric Acid; Glutamic Acid; Glycine; Histidine; Leucine; Lysine; Nitrogen; Nitrogen Isotopes; Phenylalanine; Serine; Soil; Tryptophan | 2022 |
Phytochrome B enhances seed germination tolerance to high temperature by reducing S-nitrosylation of HFR1.
Topics: Abscisic Acid; Arabidopsis; Arabidopsis Proteins; Cysteine; DNA-Binding Proteins; Gene Expression Regulation, Plant; Germination; Gibberellins; Light; Phytochrome; Phytochrome B; Protein S; Seeds; Serine; Temperature; Transcription Factors | 2022 |
Stereoselective α-Deuteration of Serine, Cysteine, Selenocysteine, and 2,3-Diaminopropanoic Acid Derivatives.
Topics: Alcohols; Amines; beta-Alanine; Carbocysteine; Cysteine; Selenocysteine; Serine | 2022 |
Characterization of human cystathionine γ-lyase enzyme activities toward d-amino acids.
Topics: Alanine; Amino Acid Isomerases; Amino Acids; Animals; Cystathionine; Cystathionine gamma-Lyase; Cysteine; Escherichia coli; Homoserine; Humans; Hydro-Lyases; Lyases; Mammals; Racemases and Epimerases; Serine | 2022 |
Loss of the Rhodobacter capsulatus Serine Acetyl Transferase Gene,
Topics: Biofilms; Cysteine; DNA; Gene Expression Regulation, Bacterial; Gene Transfer, Horizontal; Phenotype; Rhodobacter capsulatus; Serine; Serine O-Acetyltransferase | 2022 |
Transcriptomic and proteomic analysis of Staphylococcus aureus response to cuminaldehyde stress.
Topics: Adenosine Triphosphate; Amino Acids, Branched-Chain; Animals; Anti-Bacterial Agents; Bacterial Proteins; Benzaldehydes; Betaine; Cattle; Cymenes; Cysteine; DNA, Single-Stranded; Fatty Acids; Gene Expression Regulation, Bacterial; Glycine; Iron; Methionine; Peptidoglycan; Proteomics; Serine; Staphylococcal Infections; Staphylococcus aureus; Threonine; Transcriptome | 2022 |
Gut dysbiosis and inflammatory blood markers precede HIV with limited changes after early seroconversion.
Topics: B-Cell Activating Factor; Bile Acids and Salts; Biomarkers; Cross-Sectional Studies; Cysteine; Dysbiosis; HIV Infections; Humans; Interleukin-8; Lipids; Lithocholic Acid; Serine; Seroconversion; Sphingosine; Sulfates; Tumor Necrosis Factor-alpha | 2022 |
Gatekeeper Residue Replacement in a Phosphite Transporter Enhances Mutational Robustness of the Biocontainment Strategy.
Topics: ATP-Binding Cassette Transporters; Bacterial Proteins; Cysteine; Escherichia coli; Mutation; Phenylalanine; Phosphates; Phosphites; Phosphorus; Serine | 2022 |
LncRNA MSC-AS1, as an oncogene in melanoma, promotes the proliferation and glutaminolysis by regulating the miR-330-3p/ YAP1 axis.
Topics: Alanine; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cysteine; Gene Expression Regulation, Neoplastic; Glutamates; Glutaminase; Glutamine; Humans; Ketoglutaric Acids; Melanoma; MicroRNAs; Oncogenes; RNA, Long Noncoding; Serine; YAP-Signaling Proteins | 2022 |
Separation of the enantiomers of underivatized amino acids by using serially connected dual column high-performance liquid chromatography-tandem mass spectrometry.
Topics: Acetonitriles; Amines; Amino Acids; Aspartic Acid; Chromatography, High Pressure Liquid; Chromatography, Liquid; Crown Ethers; Cysteine; Ethanol; Humans; Methionine; Phenylalanine; Proline; Serine; Stereoisomerism; Tandem Mass Spectrometry; Water | 2022 |
Effects of hydrogen peroxide and l-tryptophan on antioxidative potential, apoptosis, and mammalian target of rapamycin signaling in bovine intestinal epithelial cells.
Topics: Alanine; Animals; Antioxidants; Apoptosis; Catalase; Cattle; Cysteine; Epithelial Cells; Hydrogen Peroxide; Large Neutral Amino Acid-Transporter 1; Mammals; Oxidative Stress; Serine; Signal Transduction; Superoxide Dismutase; TOR Serine-Threonine Kinases; Tryptophan | 2022 |
Cysteine restriction-specific effects of sulfur amino acid restriction on lipid metabolism.
Topics: Amino Acids, Sulfur; Animals; Cross-Sectional Studies; Cysteine; Female; Humans; Lipid Metabolism; Male; Methionine; Mice; Obesity; Serine | 2022 |
Proteomic analysis of digestive tract peptidases and lipases from the invasive gastropod Pomacea canaliculata.
Topics: Animals; Cysteine; Gastrointestinal Tract; Gastropoda; Metalloproteases; Peptides; Proteomics; Serine; Serine Endopeptidases; Serine Proteases | 2023 |
Procyanidin B2 3,3″-di-O-gallate suppresses IFN-γ production in murine CD4
Topics: Alanine; Amino Acid Transport System ASC; Amino Acids; Animals; CD4-Positive T-Lymphocytes; Cysteine; Glutamine; Interferon-gamma; Mammals; Mice; Minor Histocompatibility Antigens; Proanthocyanidins; Serine; T-Lymphocytes; TOR Serine-Threonine Kinases | 2023 |
[Preliminary exploration of the metabolic profile and metabolic pathways in newly diagnosed multiple myeloma].
Topics: Adult; Aged; Biomarkers; Cysteine; Female; Humans; Male; Metabolic Networks and Pathways; Metabolome; Metabolomics; Methionine; Middle Aged; Multiple Myeloma; Phenylalanine; Reproducibility of Results; Serine; Threonine | 2022 |
Heat Capacities of L-Cysteine, L-Serine, L-Threonine, L-Lysine, and L-Methionine.
Topics: Cysteine; Hot Temperature; Lysine; Methionine; Serine; Threonine | 2023 |
Structural insights into latency of the metallopeptidase ulilysin (lysargiNase) and its unexpected inhibition by a sulfonyl-fluoride inhibitor of serine peptidases.
Topics: Calcium; Crystallography, X-Ray; Cysteine; Fluorides; Metalloproteases; Peptide Hydrolases; Protein Conformation; Serine; Zinc | 2023 |
Comprehensive Metabolic Tracing Reveals the Origin and Catabolism of Cysteine in Mammalian Tissues and Tumors.
Topics: Animals; Carcinogenesis; Cysteine; Cystine; Glutathione; Mammals; Mice; Neoplasms; Serine | 2023 |
Mammalian D-Cysteine: A new addition to the growing family of biologically relevant D-amino acids.
Topics: Amino Acids; Animals; Cysteine; Humans; Mammals; Proteins; Serine; Stereoisomerism | 2023 |
Serine-/Cysteine-Based sp
Topics: Adjuvants, Immunologic; Adjuvants, Pharmaceutic; Animals; Asthma; CD8-Positive T-Lymphocytes; Cysteine; Cytokines; Disease Models, Animal; Immunotherapy; Mice; Mice, Inbred BALB C; Ovalbumin; Serine; Th2 Cells; Toll-Like Receptor 4 | 2023 |
Standardized ileal digestibility of amino acids in cottonseed meal fed to pregnant and non-pregnant sows.
Topics: Amino Acids; Animal Feed; Animal Nutritional Physiological Phenomena; Animals; Aspartic Acid; Cottonseed Oil; Cysteine; Diet; Digestion; Female; Glycine max; Ileum; Methionine; Pregnancy; Serine; Swine; Threonine; Tyrosine | 2023 |
lncRNA SYTL5-OT4 promotes vessel co-option by inhibiting the autophagic degradation of ASCT2.
Topics: Alanine; Carrier Proteins; Cell Line, Tumor; Cysteine; Humans; In Situ Hybridization, Fluorescence; Liver Neoplasms; Membrane Proteins; Membrane Transport Proteins; RNA, Long Noncoding; Serine | 2023 |
Oxidation and Phenolysis of Peptide/Protein C-Terminal Hydrazides Afford Salicylaldehyde Ester Surrogates for Chemical Protein Synthesis.
Topics: Cysteine; Esters; Peptides; Protein C; Proteins; Serine; Threonine | 2023 |
Cytological and transcriptomic analysis to unveil the mechanism of web blotch resistance in Peanut.
Topics: Acetyltransferases; Arachis; Cysteine; Gene Expression Profiling; Reproducibility of Results; Serine; Transcriptome | 2023 |
Methionine-CBS axis promotes intracellular ROS levels by reprogramming serine metabolism.
Topics: Cysteine; Methionine; Racemethionine; Reactive Oxygen Species; S-Adenosylmethionine; Serine | 2023 |
Quantitative structure-activity relationships of the bitter thresholds of amino acids, peptides, and their derivatives.
Topics: Amino Acids; Humans; Mathematics; Peptides; Structure-Activity Relationship; Taste | 1987 |
Expression cloning of a Na+-independent aromatic amino acid transporter with structural similarity to H+/monocarboxylate transporters.
Topics: Amino Acid Sequence; Amino Acid Transport Systems; Amino Acid Transport Systems, Neutral; Animals; Anion Transport Proteins; Bacterial Proteins; Carrier Proteins; Cloning, Molecular; Escherichia coli Proteins; Female; Intestine, Small; Kinetics; Levodopa; Mice; Molecular Sequence Data; Oocytes; Phenylalanine; Rats; Recombinant Proteins; Sequence Alignment; Sequence Homology, Amino Acid; Substrate Specificity; Tryptophan; Tyrosine; Xenopus laevis | 2001 |
A green fluorescent chemosensor for amino acids provides a versatile high-throughput screening (HTS) assay for proteases.
Topics: Amino Acids; Copper; Drug Evaluation, Preclinical; Endopeptidases; Fluoresceins; Fluorescence; Kinetics; Ligands; Molecular Probes | 2003 |
Three-dimensional quantitative structure-activity relationship analyses of substrates of the human proton-coupled amino acid transporter 1 (hPAT1).
Topics: Amino Acid Transport Systems; Caco-2 Cells; Endocytosis; Humans; Kinetics; Models, Chemical; Models, Molecular; Molecular Conformation; Quantitative Structure-Activity Relationship; Substrate Specificity; Symporters | 2011 |
A Perspective on Medicinal Chemistry Approaches for Targeting Pyruvate Kinase M2.
Topics: Allosteric Regulation; Allosteric Site; Carrier Proteins; Chemistry, Pharmaceutical; Glycolysis; Humans; Membrane Proteins; Protein Kinase Inhibitors; Thyroid Hormone-Binding Proteins; Thyroid Hormones | 2022 |