cysteine and pyrrolidonecarboxylic acid

cysteine has been researched along with pyrrolidonecarboxylic acid in 75 studies

Research

Studies (75)

Timeframe	Studies, this research(%)	All Research%
pre-1990	19 (25.33)	18.7374
1990's	34 (45.33)	18.2507
2000's	13 (17.33)	29.6817
2010's	8 (10.67)	24.3611
2020's	1 (1.33)	2.80

Authors

Authors	Studies
Meister, A	3
Lusty, CJ	1
Banks, MF; Coloso, RM; Garcia, RA; Stipanuk, MH	1
Coloso, RM; Hirschberger, LL; Stipanuk, MH	1
Fujimoto, M; Hirata, M; Ohno, K	1
Aebi, S; Lauterburg, BH; Porta, P; Summer, K	1
Baker, DH; Chung, TK; Funk, MA	1
Ferko, AP	1
Akagi, R; Taguchi, T; Ubuka, T	1
Anderson, ME; Bridges, RJ; Meister, A; Underwood, M	1
Anderson, ME; Meister, A	2
DeGraff, WG; Mitchell, JB; Russo, A	1
Bauman, PF; Bray, TM; Smith, TK	1
Nishina, H; Ohta, J; Ubuka, T	1
Anderson, ME; Hwang, O; Meister, A	1
Stiel, L; Wapnir, RA	1
Hazelton, GA; Hjelle, JJ; Klaassen, CD	1
Meister, A; Ross, LL; Tate, SS	1
Meister, A; Palekar, AG; Tate, SS	1
Green, JP; Okonkwo, PO; Orlowski, M	1
Crowley, C; Tucker, EM; Young, JD	1
Bruggink, JE; Glazenburg, EJ; Mulder, GJ; Wolters-Keulemans, K	1
Boettcher, B; Meister, A; Williamson, JM	1
Anders, MW; Stevens, JL	1
Borum, PR; Chance, M; Emgushov, RT; Jackson, JB; Kalayjian, RC; Mayer, KH; Skowron, G; Spell, SA; Webb, LS; Yen-Lieberman, B	1
Bais, R; Baker, PW; Rofe, AM	2
Barnidge, M; Janney, CG; Neuschwander-Tetri, BA	1
Grendell, JH; Luthen, RE	1
Ensunsa, JL; Hirschberger, LL; Stipanuk, MH	1
Bray, TM; Goss, PM; Nagy, LE	1
Banks, MF; Stipanuk, MH	1
Fujiyama, J; Hirayama, K; Yasutake, A	1
Chaudiére, J; Fougeat, S; Gerard-Monnier, D; Gourvest, JF	1
Glosson, JA; Goldberg, DI; Madsen, DC; Rowe, WB; White, RD; Wilson, DM	1
Smith, TK; Sousadias, MG	1
Baker, ER; Baker, H; DeAngelis, B; Frank, O; Hutner, SH; Khalil, M	1
Arons, MM; Bernard, GR; Morris, PE; Paz, HL; Russell, JA; Wheeler, AP; Wright, PE	1
Ali-Osman, F; Srivenugopal, KS	1
Arstrand, K; Dizdar, N; Kågedal, B; Kullman, A	1
Beani, JC; Emonet, N; Favier, A; Leccia, MT; Richard, MJ	1
Dringen, R; Hamprecht, B; Kranich, O; Sandberg, M	1
Frei, B; Gokce, N; Holbrook, M; Keaney, JF; Leaf, C; Vita, JA	1
Harris, C; Miller, JM; Nuttall, AL; Raphael, Y; Yamasoba, T	1
Barditch-Crovo, P; Borum, P; Buier, R; Goldberg, D; Kalayjian, RC; Lederman, M; Lietman, P; Noe, D; Rowe, WB; Skowron, G	1
Alghamdi, GA; Borum, PR; Jassal, SV; Logan, J; Martis, L; Moberly, JB; Moran, JE; Mupas, L; Oreopoulos, DG; Rodela, H; Story, KO; Webb, LE; Wolfson, M	1
Gwilt, PR; Leaf, CD; Li, XY; Radick, LE; Whalen, JJ	1
Dringen, R; Hamprecht, B	1
Ajami, AM; Cai, W; Lu, XM; Metges, CC; Wong, S; Young, VR; Yu, YM	1
Ajami, AM; Fukagawa, NK; Hercules, E	1
Dizdar, N; Kågedal, B; Kullman, A	1
Hammarqvist, F; Wernerman, J	1
Ajami, A; Cai, W; Lu, XM; Metges, CC; Regan, MM; Wong, S; Young, VR; Yu, YM	1
Bauer, K; Heuer, H; Papadopoulos, T	1
Alonso-Varona, A; Bilbao, P; Calle, Y; Castro, B; del Olmo, M; Palomares, T	1
Bearne, SL; Hekmat, O; Macdonnell, JE	1
An, NH; Han, MK; Jang, SI; Kim, HK; Kim, SJ; Kim, UH; Park, HJ; Park, KH; Park, KJ; Park, YR; Shin, YM	1
Assimos, DG; Holmes, RP; Milliner, DS; Wilson, DM	1
Drozak, J; Winiarska, K	1
Abe, K; Iijima, Y; Ishikawa, H; Watanabe, T	1
Lear, JD; Marcinkiewicz, M; Sinha, D; Walsh, PN	1
Barker, AJ; Mulcahy, LR; Nillni, EA	1
Lee, YC; Park, SJ	1
Bachhawat, AK; Kumar, A	1
Al Moutaery, M; Al Rayes, H; Al Swailam, R; Arshaduddin, M; Elfaki, I; Khan, HA; Tariq, M	1
Caltabiano, G; Ciruela, F; Fernández-Dueñas, V; Gandía, J; González-Muñiz, R; Morató, X; Pardo, L; Stagljar, I	1
Emmett, M	1
Føreid, S; Gadeholt, G	1
Godin, JP; Guiraud, SP; Jia, W; Kussmann, M; Martin, FP; Nydegger, A; Su, MM; Xie, GX	1
Dalle Donne, I; Galvagni, F; Giustarini, D; Milzani, A; Rossi, R; Santucci, A; Severi, FM	1
Callegari, E; Feng, S; Liu, Y; Mammenga, E; Min, JW; Qiao, F; Subedi, K; Wang, H	1
Bagum, H; Christensen, KE; Genov, M; Moloney, MG; Pretsch, A; Pretsch, D	1

Reviews

7 review(s) available for cysteine and pyrrolidonecarboxylic acid

Article	Year
Function of glutathione in kidney via the gamma-glutamyl cycle. The Medical clinics of North America, 1975, Volume: 59, Issue:3 Topics: Acyltransferases; Adult; Amino Acids; Animals; Cysteine; Dipeptidases; gamma-Glutamylcyclotransferase; gamma-Glutamyltransferase; Glutamates; Glutaminase; Glutamine; Glutathione; Glycine; Humans; Kidney; Male; Metabolism, Inborn Errors; Peptide Synthases; Pyroglutamate Hydrolase; Pyrrolidonecarboxylic Acid; Transaminases	1975
The gamma-glutamyl cycle. Diseases associated with specific enzyme deficiencies. Annals of internal medicine, 1974, Volume: 81, Issue:2 Topics: Acyltransferases; Adult; Amidohydrolases; Amino Acid Metabolism, Inborn Errors; Amino Acids; Anemia, Hemolytic; Cell Membrane Permeability; Child, Preschool; Cysteine; Erythrocytes; Female; gamma-Glutamyltransferase; Glutamates; Glutathione; Glycine; Humans; Infant; Infant, Newborn; Kidney; Male; Peptide Synthases; Proline; Pyrrolidonecarboxylic Acid	1974
An enzymatic basis for a blood-brain barrier? The gamma-glutamyl cycle-background and considerations relating to amino acid transport in the brain. Research publications - Association for Research in Nervous and Mental Disease, 1974, Volume: 53 Topics: Acyltransferases; Adult; Amidohydrolases; Amino Acids; Animals; Blood-Brain Barrier; Brain; Choroid Plexus; Cysteine; gamma-Glutamyltransferase; Glutamates; Glutamine; Glutathione; Humans; Male; Methionine Sulfoximine; Mice; Peptide Synthases; Proline; Pyrrolidonecarboxylic Acid; Rabbits	1974
Modulation of endogenous glutathione availability. Current opinion in clinical nutrition and metabolic care, 1999, Volume: 2, Issue:6 Topics: Acetylcysteine; Animals; Cysteine; Glutamine; Glutathione; Humans; Protein Precursors; Pyrrolidonecarboxylic Acid; Thiazoles; Thiazolidines	1999
[Glutathione in therapy]. Postepy higieny i medycyny doswiadczalnej, 2002, Volume: 56, Issue:4 Topics: Animals; Cysteine; Diabetes Mellitus; Glutathione; Humans; Infections; Neurodegenerative Diseases; Oxidative Stress; Pyrrolidonecarboxylic Acid; Thiazoles; Thiazolidines	2002
Antioxidants as novel agents for asthma. Mini reviews in medicinal chemistry, 2006, Volume: 6, Issue:2 Topics: Acetylcysteine; Anti-Asthmatic Agents; Antioxidants; Asthma; Cysteine; Glutathione; Humans; Oxidative Stress; Pyrrolidonecarboxylic Acid; Reactive Oxygen Species; Thiazoles; Thiazolidines	2006
Acetaminophen toxicity and 5-oxoproline (pyroglutamic acid): a tale of two cycles, one an ATP-depleting futile cycle and the other a useful cycle. Clinical journal of the American Society of Nephrology : CJASN, 2014, Volume: 9, Issue:1 Topics: Acetaminophen; Acid-Base Equilibrium; Acidosis; Adenosine Triphosphate; Analgesics, Non-Narcotic; Animals; Cysteine; Energy Metabolism; Glutathione; Humans; Poisoning; Prognosis; Pyrrolidonecarboxylic Acid; Substrate Cycling	2014

Trials

7 trial(s) available for cysteine and pyrrolidonecarboxylic acid

Article	Year
A phase I/II trial of intravenous L-2-oxothiazolidine-4-carboxylic acid (procysteine) in asymptomatic HIV-infected subjects. Journal of acquired immune deficiency syndromes, 1994, Volume: 7, Issue:4 Topics: Adult; Aged; beta 2-Microglobulin; CD4-Positive T-Lymphocytes; Cysteine; Female; Glutathione; HIV Seropositivity; Humans; Infusions, Intravenous; Leukocyte Count; Male; Middle Aged; Pyrrolidonecarboxylic Acid; Thiazoles; Thiazolidines	1994
A trial of antioxidants N-acetylcysteine and procysteine in ARDS. The Antioxidant in ARDS Study Group. Chest, 1997, Volume: 112, Issue:1 Topics: Acetylcysteine; Adult; Antioxidants; Bilirubin; Bronchoalveolar Lavage Fluid; Cardiac Output; Cysteine; Double-Blind Method; Free Radical Scavengers; Glutathione; Humans; Middle Aged; Prospective Studies; Pyrrolidonecarboxylic Acid; Respiration, Artificial; Respiratory Distress Syndrome; Thiazoles; Thiazolidines; Time Factors	1997
L-2-Oxothiazolidine-4-carboxylic acid reverses endothelial dysfunction in patients with coronary artery disease. The Journal of clinical investigation, 1998, Mar-15, Volume: 101, Issue:6 Topics: Administration, Oral; Aged; Arteriosclerosis; Blood Flow Velocity; Blood Glucose; Blood Pressure; Cholesterol; Coronary Disease; Cysteine; Double-Blind Method; Endothelium, Vascular; Female; Glutathione; Heart Rate; Humans; Hyperemia; Male; Middle Aged; Nitric Oxide; Nitroglycerin; Oxidation-Reduction; Pyrrolidonecarboxylic Acid; Thiazoles; Thiazolidines; Triglycerides; Ultrasonography	1998
A phase I/II evaluation of oral L-2-oxothiazolidine-4-carboxylic acid in asymptomatic patients infected with human immunodeficiency virus. Journal of clinical pharmacology, 1998, Volume: 38, Issue:4 Topics: Adult; Anti-HIV Agents; Cysteine; Dose-Response Relationship, Drug; Double-Blind Method; Glutathione; HIV Infections; Humans; Leukocytes, Mononuclear; Middle Aged; Prodrugs; Pyrrolidonecarboxylic Acid; Thiazoles; Thiazolidines	1998
Elevation of whole-blood glutathione in peritoneal dialysis patients by L-2-oxothiazolidine-4-carboxylate, a cysteine prodrug (Procysteine). Journal of the American Society of Nephrology : JASN, 1998, Volume: 9, Issue:6 Topics: Administration, Oral; Cysteine; Double-Blind Method; Female; Glutathione; Humans; Kidney Failure, Chronic; Male; Middle Aged; Osmolar Concentration; Peritoneal Dialysis, Continuous Ambulatory; Prospective Studies; Pyrrolidonecarboxylic Acid; Thiazoles; Thiazolidines	1998
Plasma L-5-oxoproline carbon and nitrogen kinetics in healthy young adults. The Journal of nutrition, 1999, Volume: 129, Issue:11 Topics: Adult; Carbon; Cross-Over Studies; Cysteine; Diet; Fasting; Food; Humans; Male; Nitrogen; Pyrrolidonecarboxylic Acid	1999
(L)-2-oxothiazolidine-4-carboxylate in the treatment of primary hyperoxaluria type 1. BJU international, 2001, Volume: 88, Issue:9 Topics: Calcium Oxalate; Calcium, Dietary; Cysteine; Female; Humans; Hyperoxaluria, Primary; Infusions, Intravenous; Male; Middle Aged; Pyrrolidonecarboxylic Acid; Thiazoles; Thiazolidines; Treatment Outcome	2001

Other Studies

61 other study(ies) available for cysteine and pyrrolidonecarboxylic acid

Article	Year
Detection of an enzyme bound gamma-glutamyl acyl ester of carbamyl phosphate synthetase of Escherichia coli. FEBS letters, 1992, Dec-14, Volume: 314, Issue:2 Topics: Acids; Binding Sites; Carbamoyl-Phosphate Synthase (Glutamine-Hydrolyzing); Cysteine; Escherichia coli; Esters; Glutamates; Glutamine; Hydrolysis; Hydroxamic Acids; Kinetics; Mutation; Pyrrolidonecarboxylic Acid; Serine	1992
Cysteine concentration regulates cysteine metabolism to glutathione, sulfate and taurine in rat hepatocytes. The Journal of nutrition, 1992, Volume: 122, Issue:3 Topics: Animals; Cells, Cultured; Chelating Agents; Cysteine; Glutathione; Indicators and Reagents; Liver; Male; Methionine; Phenanthrolines; Pyrrolidonecarboxylic Acid; Rats; Rats, Inbred Strains; Sulfates; Taurine; Thiazoles; Thiazolidines	1992
Uptake and metabolism of L-2-oxo-[35S]thiazolidine-4-carboxylate by rat cells is slower than that of L-[35S]cysteine or L-[35S]methionine. The Journal of nutrition, 1991, Volume: 121, Issue:9 Topics: Animals; Biological Transport; Chromatography, High Pressure Liquid; Cysteine; Glutathione; In Vitro Techniques; Intestine, Small; Kidney Tubules; Liver; Male; Methionine; Pyrrolidonecarboxylic Acid; Rats; Rats, Inbred Strains; Sulfur Radioisotopes; Thiazoles; Thiazolidines	1991
Protective effect of prostaglandin A2 against menadione-induced cell injury in cultured porcine aorta endothelial cells. Chemico-biological interactions, 1991, Volume: 78, Issue:1 Topics: Animals; Aorta; Cells, Cultured; Cysteine; Dose-Response Relationship, Drug; Endothelium, Vascular; Glutathione; Methionine; Prostaglandins A; Pyrrolidonecarboxylic Acid; Swine; Thiazoles; Thiazolidines; Time Factors; Vitamin K	1991
L-2-oxothiazolidine-4-carboxylic acid, a cysteine prodrug: pharmacokinetics and effects on thiols in plasma and lymphocytes in human. The Journal of pharmacology and experimental therapeutics, 1991, Volume: 257, Issue:1 Topics: Adult; Cysteine; Glutathione; Humans; Lymphocytes; Male; Middle Aged; Prodrugs; Pyrrolidonecarboxylic Acid; Thiazoles; Thiazolidines	1991
L-2-oxothiazolidine-4-carboxylate as a cysteine precursor: efficacy for growth and hepatic glutathione synthesis in chicks and rats. The Journal of nutrition, 1990, Volume: 120, Issue:2 Topics: Administration, Oral; Animals; Chickens; Cysteine; Diet; Glutathione; Liver; Male; Pyrrolidonecarboxylic Acid; Random Allocation; Rats; Rats, Inbred Strains; Regression Analysis; Thiazoles; Thiazolidines; Weight Gain	1990
The interaction between ethanol and cysteine on the central depressant effects of ethanol in mice. Pharmacology, biochemistry, and behavior, 1990, Volume: 36, Issue:3 Topics: Animals; Cysteine; Drug Synergism; Ethanol; gamma-Aminobutyric Acid; Injections, Intraventricular; Isethionic Acid; Male; Mice; Posture; Pyrrolidonecarboxylic Acid; Reflex; Thiazoles; Thiazolidines	1990
Tissue contents and urinary excretion of taurine after administration of L-cysteine and L-2-oxothiazolidine-4-carboxylate to rats. Acta medica Okayama, 1990, Volume: 44, Issue:3 Topics: Animals; Caseins; Cysteine; Cysteine Dioxygenase; Cystine; Dietary Proteins; Dioxygenases; Injections, Intraperitoneal; Liver; Male; Oxygenases; Pyrrolidonecarboxylic Acid; Rats; Rats, Inbred Strains; Taurine; Thiazoles; Thiazolidines; Tissue Distribution	1990
Glutathione metabolism at the blood-cerebrospinal fluid barrier. FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 1989, Volume: 3, Issue:13 Topics: Animals; Antimetabolites; Biological Transport; Blood-Brain Barrier; Buthionine Sulfoximine; Choroid Plexus; Cysteine; Dipeptides; gamma-Glutamyltransferase; Glutathione; Isoxazoles; Male; Methionine Sulfoximine; Pyrrolidonecarboxylic Acid; Rats; Rats, Inbred Strains; Thiazoles; Thiazolidines	1989
Marked increase of cysteine levels in many regions of the brain after administration of 2-oxothiazolidine-4-carboxylate. FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 1989, Volume: 3, Issue:5 Topics: Animals; Brain; Brain Stem; Caudate Nucleus; Cerebellum; Cerebral Cortex; Cysteine; Glutathione; Hypothalamus; Male; Mice; Pons; Pyrrolidonecarboxylic Acid; Rats; Rats, Inbred Strains; Thiazoles; Thiazolidines	1989
Glutathione depletion greatly reduces neocarzinostatin cytotoxicity in Chinese hamster V79 cells. The Journal of biological chemistry, 1985, Jul-15, Volume: 260, Issue:14 Topics: Animals; Antibiotics, Antineoplastic; Cell Line; Cell Survival; Chromatography, High Pressure Liquid; Cricetinae; Cricetulus; Cysteine; Glutathione; Pyrrolidonecarboxylic Acid; Thiazoles; Thiazolidines; Zinostatin	1985
Intracellular delivery of cysteine. Methods in enzymology, 1987, Volume: 143 Topics: Animals; Biological Transport; Cysteine; Glutathione; Mice; Pyrrolidonecarboxylic Acid; Radioisotope Dilution Technique; Sulfur Radioisotopes; Thiazoles; Thiazolidines; Tissue Distribution	1987
Effect of dietary protein deficiency and L-2-oxothiazolidine-4-carboxylate on the diurnal rhythm of hepatic glutathione in the rat. The Journal of nutrition, 1988, Volume: 118, Issue:8 Topics: Analysis of Variance; Animals; Body Weight; Circadian Rhythm; Cysteine; Diet; Glutathione; Liver; Male; Protein Deficiency; Pyrrolidonecarboxylic Acid; Rats; Rats, Inbred Strains; Thiazoles; Thiazolidines; Time Factors	1988
Effect of L-2-oxothiazolidine-4-carboxylate administration on glutathione and cysteine concentrations in guinea pig liver and kidney. Physiological chemistry and physics and medical NMR, 1987, Volume: 19, Issue:1 Topics: Animals; Cysteine; Glutathione; Guinea Pigs; Kidney; Kinetics; Liver; Male; Pyrrolidonecarboxylic Acid; Thiazoles; Thiazolidines	1987
Intracellular cysteine and glutathione delivery systems. Journal of the American College of Nutrition, 1986, Volume: 5, Issue:2 Topics: Acetaminophen; Animals; Biological Transport, Active; Cysteine; Dipeptides; Glutathione; Intracellular Fluid; Kidney; Liver; Mice; Models, Biological; Pyroglutamate Hydrolase; Pyrrolidonecarboxylic Acid; Sulfur; Thiazoles; Thiazolidines	1986
Zinc intestinal absorption in rats: specificity of amino acids as ligands. The Journal of nutrition, 1986, Volume: 116, Issue:11 Topics: Acetylcysteine; Amino Acids; Animals; Colon; Cysteine; Histidine; Ileum; Imidazoles; Indoles; Intestinal Absorption; Jejunum; Kinetics; Male; Proline; Pyrrolidonecarboxylic Acid; Rats; Rats, Inbred Strains; Tryptophan; Zinc	1986
Effects of cysteine pro-drugs on acetaminophen-induced hepatotoxicity. The Journal of pharmacology and experimental therapeutics, 1986, Volume: 237, Issue:1 Topics: Acetaminophen; Acetylcysteine; Animals; Biotransformation; Cysteine; Glucuronates; Glucuronic Acid; Glutathione; Kinetics; Liver; Liver Glycogen; Male; Mice; Phosphoadenosine Phosphosulfate; Protein Binding; Pyrrolidonecarboxylic Acid; Structure-Activity Relationship; Thiazoles; Thiazolidines	1986
The -glutamyl cycle in the choroid plexus: its possible function in amino acid transport. Proceedings of the National Academy of Sciences of the United States of America, 1973, Volume: 70, Issue:5 Topics: Acyltransferases; Amino Acids; Aminobutyrates; Animals; Biological Transport; Brain; Choroid Plexus; Cysteine; gamma-Glutamyltransferase; Glutamates; Glutathione; Glycine; Kidney; Ligases; Methionine; Proline; Pyrrolidonecarboxylic Acid; Rabbits	1973
Formation of 5-oxoproline from glutathione in erythrocytes by the gamma-glutamyltranspeptidase-cyclotransferase pathway. Proceedings of the National Academy of Sciences of the United States of America, 1974, Volume: 71, Issue:2 Topics: Acyltransferases; Animals; Carbon Radioisotopes; Cell Membrane; Cysteine; Dipeptidases; Erythrocytes; gamma-Glutamyltransferase; Glutamates; Glutathione; Glycine; In Vitro Techniques; Methionine; Peptide Synthases; Pyrrolidonecarboxylic Acid; Rabbits	1974
Enzymes of the gamma-glutamyl cycle in the choroid plexus and brain. Journal of neurochemistry, 1974, Volume: 22, Issue:6 Topics: Acyltransferases; Animals; Brain; Carbon Radioisotopes; Cations, Monovalent; Cattle; Choroid Plexus; Chromatography, Ion Exchange; Cysteine; Enzyme Activation; gamma-Glutamyltransferase; Glutamates; Hydrogen-Ion Concentration; Kinetics; Magnesium; Organ Specificity; Peptide Synthases; Potassium; Proline; Pyrrolidonecarboxylic Acid; Rabbits; Sodium; Species Specificity	1974
Red cell glutathione deficiency: clinical and biochemical investigations using sheep as an experimental model system. British journal of haematology, 1981, Volume: 48, Issue:3 Topics: Anemia; Animals; Cysteine; Disease Models, Animal; Erythrocyte Aging; Erythrocytes; Glutamate-Cysteine Ligase; Glutathione; Nitrites; Phenylhydrazines; Pyrrolidonecarboxylic Acid; Sheep; Sulfoxides	1981
Inhibition of glutathione efflux in the recirculating rat liver perfusion by cysteine but not by oxothiazolidine carboxylate, an intracellular cysteine precursor. FEBS letters, 1984, Dec-10, Volume: 178, Issue:2 Topics: Animals; Cysteine; Glutathione; In Vitro Techniques; Kinetics; Liver; Male; Perfusion; Pyrrolidonecarboxylic Acid; Rats; Rats, Inbred Strains; Thiazoles; Thiazolidines	1984
Intracellular cysteine delivery system that protects against toxicity by promoting glutathione synthesis. Proceedings of the National Academy of Sciences of the United States of America, 1982, Volume: 79, Issue:20 Topics: Acetaminophen; Animals; Cysteine; Glutathione; Glutathione Synthase; Inactivation, Metabolic; Liver; Mice; Pyrrolidonecarboxylic Acid; Thiazoles; Thiazolidines	1982
Metabolism of haloforms to carbon monoxide. IV. studies on the reaction mechanism in vivo. Chemico-biological interactions, 1981, Volume: 37, Issue:3 Topics: Animals; Carbon Monoxide; Carcinogens; Chloroform; Cysteine; Deuterium; Hydrocarbons, Brominated; Male; Maleates; Phenobarbital; Pyrrolidonecarboxylic Acid; Rats; Rats, Inbred Strains; Thiazoles; Thiazolidines; Trihalomethanes	1981
The efficacy of (L)-2-oxothiazolidine-4-carboxylate (OTC) and (L)-cysteine in reducing urinary oxalate excretion. The Journal of urology, 1994, Volume: 152, Issue:6 Pt 1 Topics: Animals; Calcium Oxalate; Cysteine; Male; Metabolism; Pyrrolidonecarboxylic Acid; Rats; Thiazoles; Thiazolidines; Time Factors	1994
Cerulein-induced pancreatic cysteine depletion: prevention does not diminish acute pancreatitis in the mouse. Gastroenterology, 1994, Volume: 107, Issue:3 Topics: Animals; Ceruletide; Cysteine; Dose-Response Relationship, Drug; Female; Glutathione; Mice; Mice, Inbred Strains; Pancreas; Pancreatitis; Pyrrolidonecarboxylic Acid; Thiazoles; Thiazolidines; Time Factors	1994
Thiol metabolism and acute pancreatitis: trying to make the pieces fit. Gastroenterology, 1994, Volume: 107, Issue:3 Topics: Acute Disease; Animals; Ceruletide; Cysteine; Glutathione; Pancreas; Pancreatitis; Pyrrolidonecarboxylic Acid; Sulfhydryl Compounds; Thiazoles; Thiazolidines	1994
Catabolism of cysteine, cystine, cysteinesulfinate, and OTC by isolated perfused rat hindquarter. The American journal of physiology, 1993, Volume: 264, Issue:5 Pt 1 Topics: Adenine Nucleotides; Animals; Cysteine; Cystine; Hindlimb; In Vitro Techniques; Lactates; Male; Muscles; Neurotransmitter Agents; Perfusion; Phosphocreatine; Pyrrolidonecarboxylic Acid; Pyruvates; Radioisotope Dilution Technique; Rats; Rats, Sprague-Dawley; Sulfates; Sulfur Radioisotopes; Taurine; Thiazoles; Thiazolidines	1993
Regulation of hepatocyte glutathione by amino acid precursors and cAMP in protein-energy malnourished rats. The Journal of nutrition, 1994, Volume: 124, Issue:3 Topics: Amino Acids; Animals; Cells, Cultured; Cyclic AMP; Cysteine; Glutathione; Homeostasis; Liver; Male; Methionine; Oxygen; Protein-Energy Malnutrition; Pyrrolidonecarboxylic Acid; Rats; Rats, Wistar; Thiazoles; Thiazolidines	1994
The utilization of N-acetylcysteine and 2-oxothiazolidine-4-carboxylate by rat hepatocytes is limited by their rate of uptake and conversion to cysteine. The Journal of nutrition, 1994, Volume: 124, Issue:3 Topics: Acetylcysteine; Animals; Cells, Cultured; Culture Media; Cysteine; Glutathione; Liver; Male; Pyrrolidonecarboxylic Acid; Rats; Rats, Sprague-Dawley; Selenium Radioisotopes; Thiazoles; Thiazolidines	1994
Mechanism of methylmercury efflux from cultured astrocytes. Biochemical pharmacology, 1994, Apr-29, Volume: 47, Issue:9 Topics: Animals; Astrocytes; Buthionine Sulfoximine; Cells, Cultured; Cysteine; Glutathione; Methionine Sulfoximine; Methylmercury Compounds; Probenecid; Pyrrolidonecarboxylic Acid; Rats; Thiazoles; Thiazolidines	1994
Partial prevention of glutathione depletion in rats following acute intoxication with diethylmaleate. Clinical physiology and biochemistry, 1993, Volume: 10, Issue:1 Topics: Animals; Brain; Cysteine; Glutathione; Heart; Kidney; Liver; Male; Maleates; Myocardium; Pyrrolidonecarboxylic Acid; Rats; Rats, Sprague-Dawley; Thiazoles; Thiazolidines	1993
Toxicity evaluations of L-cysteine and Procysteine, a cysteine prodrug, given once intravenously to neonatal rats. Toxicology letters, 1993, Volume: 69, Issue:1 Topics: Animals; Animals, Newborn; Body Weight; Cysteine; Injections, Intravenous; Organ Size; Prodrugs; Pyrrolidonecarboxylic Acid; Rats; Rats, Sprague-Dawley; Thiazoles; Thiazolidines	1993
Toxicity and growth-promoting potential of spermine when fed to chicks. Journal of animal science, 1995, Volume: 73, Issue:8 Topics: Adenosylmethionine Decarboxylase; Animal Feed; Animals; Chickens; Cysteine; Diet; Dose-Response Relationship, Drug; Eating; Glutathione; Kidney; Liver; Male; Muscle, Skeletal; Ornithine; Ornithine Decarboxylase; Polyamines; Putrescine; Pyrrolidonecarboxylic Acid; Spermine; Thiazoles; Thiazolidines	1995
Antioxidant survey to assess antagonism to redox stress using a prokaryotic and an eukaryotic system. Experientia, 1996, Jun-15, Volume: 52, Issue:6 Topics: Antioxidants; Buthionine Sulfoximine; Cysteine; Escherichia coli; Eukaryota; Free Radicals; Glutathione; Homocysteine; Methionine Sulfoximine; Oxidative Stress; Pyrrolidonecarboxylic Acid; Thiazoles; Thiazolidines; Vitamin K; Vitamin K 3	1996
Activity and distribution of the cysteine prodrug activating enzyme, 5-oxo-L-prolinase, in human normal and tumor tissues. Cancer letters, 1997, Jul-15, Volume: 117, Issue:1 Topics: Cysteine; Humans; Neoplasms; Prodrugs; Pyroglutamate Hydrolase; Pyrrolidonecarboxylic Acid; Thiazoles; Thiazolidines	1997
Effects on interstitial glutathione, cysteine and 5-S-cysteinyldopa of buthionine sulphoximine in human melanoma transplants. Melanoma research, 1997, Volume: 7, Issue:4 Topics: Acetylcysteine; Animals; Antimetabolites, Antineoplastic; Buthionine Sulfoximine; Cysteine; Cysteinyldopa; Drug Interactions; Enzyme Inhibitors; Glutathione; Humans; Melanoma; Mice; Mice, Inbred BALB C; Mice, Nude; Microdialysis; Neoplasm Transplantation; Pyrrolidonecarboxylic Acid; Thiazoles; Thiazolidines	1997
Thiols and selenium: protective effect on human skin fibroblasts exposed to UVA radiation. Journal of photochemistry and photobiology. B, Biology, 1997, Volume: 40, Issue:1 Topics: Acetylcysteine; Antioxidants; Cell Survival; Cells, Cultured; Cysteine; Dose-Response Relationship, Radiation; Female; Fibroblasts; Glutathione; Humans; Pyrrolidonecarboxylic Acid; Radiation-Protective Agents; Skin; Sodium Selenite; Surgery, Plastic; Thiazoles; Thiazolidines; Thiophenes; Ultraviolet Rays	1997
Utilization of cysteine and cysteine precursors for the synthesis of glutathione in astroglial cultures: preference for cystine. Glia, 1998, Volume: 22, Issue:1 Topics: Animals; Astrocytes; Brain; Brain Chemistry; Cell Survival; Cells, Cultured; Cystathionine; Cysteine; Cystine; gamma-Glutamyltransferase; Glutathione; Methionine; Nerve Tissue Proteins; Pyrrolidonecarboxylic Acid; Rats; Rats, Wistar; Thiazoles; Thiazolidines	1998
Role of glutathione in protection against noise-induced hearing loss. Brain research, 1998, Feb-16, Volume: 784, Issue:1-2 Topics: Animals; Antioxidants; Auditory Threshold; Buthionine Sulfoximine; Chromatography, High Pressure Liquid; Cochlea; Cysteine; Evoked Potentials, Auditory, Brain Stem; Female; Glutathione; Guinea Pigs; Hearing Loss, Noise-Induced; Prodrugs; Pyrrolidonecarboxylic Acid; Thiazoles; Thiazolidines	1998
The effect of (L)-cysteine and (L)-2-oxothiazolidine-4-carboxylic acid (OTZ) on urinary oxalate excretion: studies using a hyperoxaluric rat model. The Journal of urology, 1998, Volume: 159, Issue:6 Topics: Animals; Cysteine; Disease Models, Animal; Male; Oxalates; Pyrrolidonecarboxylic Acid; Rats; Rats, Inbred Strains; Thiazoles; Thiazolidines; Urinary Calculi	1998
Pharmacokinetics of 2-oxothiazolidine-4-carboxylate, a cysteine prodrug, and cysteine. Journal of clinical pharmacology, 1998, Volume: 38, Issue:10 Topics: Adult; Cysteine; Glutathione; Humans; Infusions, Intravenous; Male; Prodrugs; Pyrrolidonecarboxylic Acid; Thiazoles; Thiazolidines	1998
N-acetylcysteine, but not methionine or 2-oxothiazolidine-4-carboxylate, serves as cysteine donor for the synthesis of glutathione in cultured neurons derived from embryonal rat brain. Neuroscience letters, 1999, Jan-08, Volume: 259, Issue:2 Topics: Acetylcysteine; Animals; Brain; Cells, Cultured; Cysteine; Female; Glutathione; Methionine; Neurons; Pregnancy; Pyrrolidonecarboxylic Acid; Rats; Rats, Wistar; Thiazoles; Thiazolidines	1999
L-2-[(13)C]oxothiazolidine-4-carboxylic acid: a probe for precursor mobilization for glutathione synthesis. American journal of physiology. Endocrinology and metabolism, 2000, Volume: 278, Issue:1 Topics: Acetaminophen; Adult; Aged; Breath Tests; Calorimetry, Indirect; Carbon Dioxide; Cysteine; Female; Glutathione; Humans; Kinetics; Male; Middle Aged; Models, Biological; Prodrugs; Pyrrolidonecarboxylic Acid; Thiazoles; Thiazolidines	2000
Comparison of N-acetylcysteine and l-2-oxothiazolidine-4-carboxylate as cysteine deliverers and glutathione precursors in human malignant melanoma transplants in mice. Cancer chemotherapy and pharmacology, 2000, Volume: 45, Issue:3 Topics: Acetylcysteine; Animals; Buthionine Sulfoximine; Cysteine; Cysteinyldopa; Enzyme Inhibitors; Glutathione; Humans; Melanoma; Melanoma, Experimental; Mice; Mice, Nude; Microdialysis; Neoplasm Transplantation; Protein Precursors; Pyrrolidonecarboxylic Acid; Thiazoles; Thiazolidines; Transplantation, Heterologous; Tumor Cells, Cultured	2000
Oxoproline kinetics and oxoproline urinary excretion during glycine- or sulfur amino acid-free diets in humans. American journal of physiology. Endocrinology and metabolism, 2000, Volume: 278, Issue:5 Topics: Adult; Amino Acids, Sulfur; Creatinine; Cysteine; Diet; Fasting; Food; Glycine; Humans; Kinetics; Male; Oxidation-Reduction; Pyrrolidonecarboxylic Acid	2000
Analysis of the thyrotropin-releasing hormone-degrading ectoenzyme by site-directed mutagenesis of cysteine residues. Cys68 is involved in disulfide-linked dimerization. European journal of biochemistry, 2000, Volume: 267, Issue:9 Topics: Aminopeptidases; Animals; Base Sequence; Cell Line; Cricetinae; Cysteine; Dimerization; Disulfides; DNA Primers; Mutagenesis, Site-Directed; Pyrrolidonecarboxylic Acid; Rats	2000
Effects of L-2-oxothiazolidine-4-carboxylate on the cytotoxic activity and toxicity of cyclophosphamide in mice bearing B16F10 melanoma liver metastases. Melanoma research, 2000, Volume: 10, Issue:2 Topics: Acrolein; Alkylation; Animals; Antineoplastic Agents, Alkylating; Biotransformation; Cell Division; Cyclophosphamide; Cysteine; Disease Progression; Drug Interactions; Drug Screening Assays, Antitumor; Female; Glutathione; Leukopenia; Liver Neoplasms; Melanoma, Experimental; Mice; Mice, Inbred C57BL; Oxidation-Reduction; Prodrugs; Pyrrolidonecarboxylic Acid; Thiazoles; Thiazolidines	2000
Inhibition of Escherichia coli CTP synthase by glutamate gamma-semialdehyde and the role of the allosteric effector GTP in glutamine hydrolysis. The Biochemical journal, 2001, May-15, Volume: 356, Issue:Pt 1 Topics: Allosteric Regulation; Aminobutyrates; Carbon-Nitrogen Ligases; Cysteine; Cytidine Triphosphate; Enzyme Activation; Escherichia coli; Glutamates; Glutamine; Hydrolysis; Kinetics; Models, Chemical; Mutagenesis, Site-Directed; Pyrroles; Pyrrolidonecarboxylic Acid; Quaternary Ammonium Compounds; Recombinant Proteins	2001
Antidiabetic effect of a prodrug of cysteine, L-2-oxothiazolidine-4-carboxylic acid, through CD38 dimerization and internalization. The Journal of biological chemistry, 2002, Feb-15, Volume: 277, Issue:7 Topics: ADP-ribosyl Cyclase; ADP-ribosyl Cyclase 1; Animals; Antigens, CD; Antigens, Differentiation; Antioxidants; Blood Glucose; Calcium; Cell Line; Cell Separation; Cysteine; Dimerization; Disulfides; DNA, Complementary; Dose-Response Relationship, Drug; Flow Cytometry; Glucose; Green Fluorescent Proteins; HeLa Cells; Humans; Hypoglycemic Agents; Immunohistochemistry; Islets of Langerhans; Luminescent Proteins; Membrane Glycoproteins; Mice; Mice, Inbred BALB C; Microscopy, Confocal; Mutagenesis, Site-Directed; Mutation; NAD+ Nucleosidase; Oligonucleotides, Antisense; Pyrrolidonecarboxylic Acid; Signal Transduction; Thiazoles; Thiazolidines; Time Factors; Transfection	2002
Bovine 5-oxo-L-prolinase: simple assay method, purification, cDNA cloning, and detection of mRNA in the coronary artery. Biological & pharmaceutical bulletin, 2004, Volume: 27, Issue:3 Topics: Amidohydrolases; Amino Acid Sequence; Animals; Cattle; Cloning, Molecular; Coronary Vessels; Cysteine; DNA, Complementary; Electrophoresis, Polyacrylamide Gel; Humans; In Vitro Techniques; Molecular Sequence Data; Nitrates; Pyrrolidonecarboxylic Acid; Rats; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sequence Homology, Amino Acid; Species Specificity; Thiazoles; Thiazolidines; Vasodilator Agents	2004
Factor XIa dimer in the activation of factor IX. Biochemistry, 2005, Aug-02, Volume: 44, Issue:30 Topics: Amino Acid Substitution; Cell Line; Cysteine; Dextran Sulfate; Dimerization; Factor IX; Factor XIa; Factor XIIa; Glycine; Humans; Hydrolysis; Oligopeptides; Partial Thromboplastin Time; Platelet Activation; Pyrrolidonecarboxylic Acid; Substrate Specificity; Thrombin	2005
Disruption of disulfide bond formation alters the trafficking of prothyrotropin releasing hormone (proTRH)-derived peptides. Regulatory peptides, 2006, Jan-15, Volume: 133, Issue:1-3 Topics: Amino Acid Motifs; Animals; Chromatography, Gel; Cysteine; Disulfides; Immunohistochemistry; Models, Biological; Mutation; Peptides; Protein Precursors; Protein Processing, Post-Translational; Pyrrolidonecarboxylic Acid; Rats; Secretory Vesicles; Thyrotropin-Releasing Hormone; Transfection; Tumor Cells, Cultured	2006
A futile cycle, formed between two ATP-dependant gamma-glutamyl cycle enzymes, gamma-glutamyl cysteine synthetase and 5-oxoprolinase: the cause of cellular ATP depletion in nephrotic cystinosis? Journal of biosciences, 2010, Volume: 35, Issue:1 Topics: Adenosine Triphosphate; Amino Acid Transport Systems, Neutral; Animals; Cysteine; Cystinosis; Disease Models, Animal; Glutamate-Cysteine Ligase; Glutamic Acid; Humans; Mice; Models, Biological; Pyroglutamate Hydrolase; Pyrrolidonecarboxylic Acid	2010
Protective effect of a cysteine prodrug and antioxidant, L-2-oxothiazolidine-4-carboxylate, against ethanol-induced gastric lesions in rats. Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie, 2012, Volume: 64, Issue:3 Topics: Animals; Anti-Ulcer Agents; Antioxidants; Cysteine; Disease Models, Animal; Ethanol; Female; Gastric Mucosa; Male; Prodrugs; Pyrrolidonecarboxylic Acid; Rats; Rats, Wistar; Stomach Ulcer; Thiazolidines	2012
The Parkinson's disease-associated GPR37 receptor-mediated cytotoxicity is controlled by its intracellular cysteine-rich domain. Journal of neurochemistry, 2013, Volume: 125, Issue:3 Topics: Activating Transcription Factor 4; Analysis of Variance; Antibodies; Biotinylation; Calcium; Caspase 3; Cell Line, Transformed; Cell Survival; Cyclic AMP; Cysteine; Dose-Response Relationship, Drug; Enzyme Inhibitors; HEK293 Cells; Humans; Intracellular Fluid; Mutation; Neuropeptides; Protein Structure, Tertiary; Protein Transport; Pyrrolidonecarboxylic Acid; Receptors, G-Protein-Coupled; Thapsigargin; Transfection	2013
Beta-hydroxybutyrate and pyroglutamate can be included in a rapid GC-MS screening method for differential diagnosis of metabolic acidosis. Scandinavian journal of clinical and laboratory investigation, 2017, Volume: 77, Issue:2 Topics: 3-Hydroxybutyric Acid; Biomarkers; Calibration; Cysteine; Diabetic Ketoacidosis; Diagnosis, Differential; Ethylene Glycol; Gas Chromatography-Mass Spectrometry; Glycolates; Humans; Ketosis; Pyrrolidonecarboxylic Acid; Reproducibility of Results	2017
Urinary metabolic insights into host-gut microbial interactions in healthy and IBD children. World journal of gastroenterology, 2017, May-28, Volume: 23, Issue:20 Topics: Adolescent; Anthropometry; Bile Acids and Salts; Body Composition; Case-Control Studies; Child; Colitis, Ulcerative; Crohn Disease; Cysteine; Female; Gas Chromatography-Mass Spectrometry; Gastrointestinal Microbiome; Glutamic Acid; Glutathione; Glycine; Humans; Inflammation; Inflammatory Bowel Diseases; Male; Metabolome; Metabolomics; Microbial Interactions; Phenotype; Pyrrolidonecarboxylic Acid; Signal Transduction; Urine	2017
N-acetylcysteine ethyl ester as GSH enhancer in human primary endothelial cells: A comparative study with other drugs. Free radical biology & medicine, 2018, Volume: 126 Topics: Acetylcysteine; Cell Proliferation; Culture Media; Cysteine; Endothelial Cells; Ethyl Ethers; Glutathione; Human Umbilical Vein Endothelial Cells; Humans; Pyrrolidonecarboxylic Acid; Thiazolidines	2018
Therapeutic Role of a Cysteine Precursor, OTC, in Ischemic Stroke Is Mediated by Improved Proteostasis in Mice. Translational stroke research, 2020, Volume: 11, Issue:1 Topics: Adaptor Proteins, Signal Transducing; Animals; Autophagy-Related Proteins; Brain Ischemia; Cells, Cultured; Cysteine; Ischemic Stroke; Male; Mice, Inbred C57BL; Neurons; Oxidative Stress; Proteostasis; Pyrrolidonecarboxylic Acid; Thiazolidines	2020
Synthetic Access to 3-Substituted Pyroglutamic Acids from Tetramate Derivatives of Serine, Threonine, The Journal of organic chemistry, 2019, 08-16, Volume: 84, Issue:16 Topics: Cysteine; Molecular Conformation; Pyrrolidonecarboxylic Acid; Serine; Stereoisomerism; Threonine	2019