cysteine has been researched along with palmitic acid in 180 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 13 (7.22) | 18.7374 |
| 1990's | 60 (33.33) | 18.2507 |
| 2000's | 83 (46.11) | 29.6817 |
| 2010's | 21 (11.67) | 24.3611 |
| 2020's | 3 (1.67) | 2.80 |
| Authors | Studies |
|---|---|
| Amarneh, B; Ktistakis, NT; Naim, HY; Roth, MG | 1 |
| Chapman, ER; Estep, RP; Storm, DR | 1 |
| Büllesbach, EE; Crouch, RK; Knapp, DR; Papac, DI; Thornburg, KR | 1 |
| Crise, B; Rose, JK | 1 |
| Benson, BJ; Griffin, PR; Lesikar, DD; Moffat, B; Naidu, A; Stults, JT | 1 |
| Kendal, A; Klenk, HD; Rott, R; Veit, M | 1 |
| Catterall, WA; Schmidt, JW | 1 |
| Bouvier, M; Caron, MG; Hnatowich, M; Lefkowitz, RJ; O'Dowd, BF | 1 |
| Skene, JH; Virág, I | 1 |
| Chen, ZQ; DuBois, G; Shih, TY; Ulsh, LS | 1 |
| Buss, JE; Sefton, BM | 1 |
| Adam, M; Johnstone, RM; Turbide, C | 1 |
| Gallwitz, D; Molenaar, CM; Prange, R | 1 |
| Rott, R; Schmidt, M; Schmidt, MF | 1 |
| Abdulaev, NG; Bogachuk, AS | 1 |
| Hämmerling, GJ; Koch, N | 2 |
| Kaufman, JF; Krangel, MS; Strominger, JL | 1 |
| Bizzozero, OA; Fridal, K; Pastuszyn, A | 1 |
| García-Cardeña, G; Liu, J; Sessa, WC | 1 |
| Grassie, MA; Guzzi, F; Magee, AI; McCallum, JF; Milligan, G; Parenti, M; Wise, A | 1 |
| Morrison, DF; O'Brien, PJ; Pepperberg, DR | 1 |
| Fujimoto, T; Laposata, M; McEver, RP; Muszbek, L; Prescott, SM; Stroud, E; Whatley, RE | 1 |
| Kornfeld, S; Rohrer, J; Schweizer, A | 1 |
| Dietzen, DJ; Hastings, WR; Lublin, DM | 1 |
| Inglese, J; Lefkowitz, RJ; Premont, RT; Randall, RR; Stoffel, RH | 1 |
| Barbee, G; Barker, PA; Misko, TP; Shooter, EM | 1 |
| Kawate, N; Menon, KM | 1 |
| Cadwallader, KA; Hancock, JF; Macdonald, SG; Paterson, H | 1 |
| Grassie, MA; Magee, AI; McCallum, JF; Milligan, G; Parenti, M | 1 |
| Degtyarev, MY; Jones, TL; Spiegel, AM | 1 |
| Koblet, H; Naim, HY; Schärer, CG | 1 |
| Kennedy, ME; Limbird, LE | 1 |
| Bhattacharya, S; Karnik, SS; Khorana, HG; Ridge, KD | 1 |
| Ivanova, L; Schlesinger, MJ | 1 |
| Clark, D; Luirink, J; Majoor, MJ; Oudega, B; Stegehuis, F | 1 |
| Sefton, BM; Yurchak, LK | 1 |
| Michel, T; Robinson, LJ | 1 |
| Hampson, DR; Pickering, DS; Salter, MW; Taverna, FA | 1 |
| Kosugi, S; Mori, T | 1 |
| Rothman, JE; Söllner, TH; Veit, M | 1 |
| Dietzen, DJ; Hastings, WR; Kurzchalia, TV; Lublin, DM; Monier, S | 1 |
| Adam, L; Bonin, H; Bouvier, M; Loisel, TP; Moffett, S; Mouillac, B | 1 |
| Leventis, R; Schroeder, H; Shahinian, S; Silvius, JR; Walton, PA | 1 |
| Bommeli, C; Hiltpold, A; Köhler, P; Papanastasiou, P | 1 |
| Reverey, H; Schmidt, MF; Veit, M | 1 |
| An, S; Blasi, J; Brose, N; Chapman, ER; Jahn, R; Johnston, PA; Südhof, TC | 1 |
| Lublin, DM; Tao, N; Wagner, SJ | 1 |
| Derynck, R; Shum, L; Turck, CW | 1 |
| Dohlman, HG; Song, J | 1 |
| Weigel, PH; Zeng, FY | 1 |
| Baron, C; Thorstenson, YR; Zambryski, PC | 1 |
| Resh, MD; van't Hof, W | 1 |
| George, SR; Jin, H; O'Dowd, BF; Zastawny, R | 1 |
| Bijlmakers, MJ; Isobe-Nakamura, M; Marsh, M; Ruddock, LJ | 1 |
| Grassie, MA; Lee, M; Milligan, G; Parenti, M; Rees, S; Wise, A | 1 |
| Benovic, JL; Loudon, RP | 1 |
| Lane, SR; Liu, Y | 1 |
| Ishisaka, R; Iwata, H; Takemura, D; Tou, E; Utsumi, T; Yabuki, M | 1 |
| Berliner, LJ; Narayan, M | 1 |
| Bernstein, LS; Blumer, KJ; Linder, ME; Srinivasa, SP | 1 |
| Harteneck, C; Ponimaskin, E; Schmidt, MF; Schultz, G | 1 |
| Chien, AJ; Gao, T; Hosey, MM; Perez-Reyes, E | 1 |
| Caballero, M; Carabaña, J; Celma, ML; Fernández-Muñoz, R; Ortego, J | 1 |
| Chien, AJ; Hosey, MM | 1 |
| Deans, JP; Polyak, MJ; Tailor, SH | 1 |
| Beck, K; Ferreira, P; Mollner, S; Pfeuffer, T | 1 |
| Chen, C; Liu-Chen, LY; Shahabi, V; Xu, W | 1 |
| Baker, TL; Booden, MA; Buss, JE; Der, CJ; Punke, SG; Solski, PA | 1 |
| Altenbach, C; Cai, K; Hubbell, WL; Khorana, HG; Langen, R | 1 |
| Altenbach, C; Cai, K; Farrens, D; Hubbell, WL; Khorana, HG; Klein-Seetharaman, J; Zhang, C | 1 |
| Popov, S; Ross, EM; Slaughter, C; Tu, Y | 1 |
| Berthiaume, LG; McCabe, JB; Vance, J; Zhao, Y | 1 |
| Blumer, KJ; Linder, ME; Manahan, CL; Patnana, M | 1 |
| Patel, TB; Scholich, K; Yigzaw, Y | 1 |
| Bhattacharyya, R; Wedegaertner, PB | 1 |
| Jones, TL; Ugur, O | 1 |
| Pidgeon, C; Post, CB; Wilkinson, TA; Yin, J | 1 |
| Adarichev, V; Behn, H; Offermanns, S; Ponimaskin, E; Schmidt, MF; Voyno-Yasenetskaya, TA | 1 |
| Blasey, H; Catsicas, S; Di Paolo, G; Grenningloh, G; Igarashi, M; Lutjens, R; Pellier, V; Pfulg, C; Ruchti, E; Staple, JK | 1 |
| Creemers, JW; Pauli, I; Plets, E; Teuchert, M; van de Loo, JW; Van de Ven, WJ | 1 |
| Higuchi, M; Izumi, KM; Kieff, E | 1 |
| Hongo, S; Li, ZN; Matsuzaki, Y; Nakamura, K; Sugahara, K; Sugawara, K; Tsuchiya, E | 1 |
| Arenzana-Seisdedos, F; Bachelerie, F; Percherancier, Y; Planchenault, T; Valenzuela-Fernandez, A; Virelizier, JL | 1 |
| Ansanay, H; Bélanger, C; Bouvier, M; Qanbar, R | 1 |
| Hawtin, SR; Patel, S; Tobin, AB; Wheatley, M | 1 |
| Batenburg, JJ; Gadella, BM; Haagsman, HP; ten Brinke, A; Vaandrager, AB; van Golde, LM | 1 |
| Dunphy, JT; Greentree, WK; Linder, ME | 1 |
| Ernberg, I; Matskova, L; Pawson, T; Winberg, G | 1 |
| Bickmeyer, U; Dumuis, A; Heine, M; Joubert, L; Ponimaskin, EG; Richter, DW; Sebben, M | 1 |
| Bowzard, JB; Courtney, RJ; Loomis, JS; Wills, JW | 1 |
| Everson, WV; Matveev, SV; Smart, EJ; Uittenbogaard, A | 1 |
| Batenburg, JJ; Haagsman, HP; ten Brinke, A; Vaandrager, AB; van Golde, LM | 1 |
| Batenburg, JJ; Haagsman, HP; Ridder, AN; ten Brinke, A; Vaandrager, AB; van Golde, LM | 1 |
| Cai, S; Exton, JH; Ho, WT; Spellman, R; Xie, Z | 1 |
| Brothers, SP; Castro-Fernández, C; Conn, PM; Fisher, RA; Janovick, JA; Ji, TH | 1 |
| Billard, M; Boucheix, C; Charrin, S; Manié, S; Oualid, M; Rubinstein, E | 1 |
| Krishnakumar, SS; Panda, D | 1 |
| Berditchevski, F; Gilbert, E; Odintsova, E; Sawada, S | 1 |
| Weigel, PH; Yik, JH | 1 |
| Chen, L; Davis, NG; Feng, Y; Roth, AF | 1 |
| Ferguson, G; Palmer, TM; Watterson, KR | 1 |
| Kinsella, BT; Lawler, OA; Miggin, SM | 1 |
| Burakoff, SJ; Fragoso, R; Jin, YJ; Ren, D; Su, MW; Zhang, X | 1 |
| Nagaraj, R; Pallavi, B | 1 |
| Nanjundan, M; Sims, PJ; Wiedmer, T; Zhao, J | 1 |
| Hemler, ME; Kolesnikova, TV; Stipp, CS | 1 |
| Hegele, RA; Liang, X; Miskie, BA; Resh, MD; Shan, J; Tran, K; Vukmirica, J; Yao, Z; Yuan, J | 1 |
| Jones, TL; Onaran, HO; Ugur, O | 1 |
| Davey, PC; Druey, KM; Hiol, A; Jones, TL; Milligan, G; Nini, L; Osterhout, JL; Waheed, AA; Wang, J; Ward, RJ | 1 |
| Chen, CK; Davey, PC; Druey, KM; Fischer, ER; Hiol, A; Jones, TL; Milligan, G; Osterhout, JL; Waheed, AA | 1 |
| Baker, TL; Buss, JE; Coloff, JL; Walker, J; Zheng, H | 1 |
| Fricker, LD; Kalinina, EV | 1 |
| Heindel, U; Schmidt, MF; Veit, M | 1 |
| Bouvier, M; Charest, PG | 1 |
| Davidson, JS; Katz, AA; Lopes, J; Maudsley, SR; Millar, RP; Pawson, AJ; Sun, YM | 1 |
| ONTKO, JA | 1 |
| Dumuis, A; Papoucheva, E; Ponimaskin, EG; Richter, DW; Sebben, M | 1 |
| Clark, KL; Eilert, KD; Johnson, ME; Oelke, A; Simpson, PC; Todd, SC | 1 |
| Acconcia, F; Ascenzi, P; Fabozzi, G; Marino, M; Visca, P | 1 |
| Kittler, JT; Moss, SJ; Rathenberg, J | 1 |
| Braun, V; El Marjou, A; Goud, B; Lallemand-Breitenbach, V; Perez, F; Poüs, C; Quesnoit, M | 1 |
| Jones, TL | 1 |
| Bacic, A; Callaghan, JM; Currie, G; Ferguson, K; McConville, MJ; McFadden, GI; Naderer, T; Spurck, T; Tull, D; Vince, JE | 1 |
| Veit, M | 1 |
| Barrientos, AA; Berthiaume, LG; Corvi, MM; Gavilanes, F; Navarro-Lérida, I; Rodríguez-Crespo, I | 1 |
| Clouser, CL; Menon, KM; Munshi, UM; Peegel, H | 1 |
| Chamberlain, LH; Gould, GW; Salaün, C | 1 |
| Dai, J; Liu, H; Treber, M; Woldegiorgis, G; Zheng, G | 1 |
| Sebti, SM; Wang, DA | 1 |
| Du, D; Gershengorn, MC; Grimberg, H; Lupu-Meiri, M; Oron, Y; Raaka, BM | 1 |
| Ablonczy, Z; Crouch, RK; Lem, J; Makino, CL; Wang, Z; Wen, XH | 1 |
| Chuttani, K; Harivardhan Reddy, L; Mishra, AK; Murthy, RS; Sharma, RK | 1 |
| Anilkumar, N; Couchman, JR; Itoh, Y; Nagase, H; Seiki, M; Uekita, T | 1 |
| Chan, WE; Chen, SS; Lin, HH | 1 |
| Berzat, AC; Buss, JE; Chenette, EJ; Cox, AD; Der, CJ; Minden, A; Shutes, A; Weinbaum, CA | 1 |
| Conrad, JT; Nash, TE; Touz, MC | 1 |
| Alvarado, D; Buglino, J; Lemmon, MA; Miura, GI; Resh, MD; Treisman, JE | 1 |
| Puertollano, R; Vergarajauregui, S | 1 |
| Arstikaitis, P; Cowan, CM; Drisdel, RC; El-Husseini, A; Gan, L; Green, WN; Hayden, MR; Huang, K; Kang, R; Mullard, A; Orban, PC; Ravikumar, B; Raymond, LA; Rubinsztein, DC; Singaraja, RR; Yanai, A | 1 |
| Dietrich, LE; Hou, H; LaGrassa, TJ; Meiringer, CT; Subramanian, K; Ungermann, C | 1 |
| Albert, PR; Chidiac, P; Mao, H; Nunn, C | 1 |
| Heinemann, U; Kümmel, D; Veit, M | 1 |
| Huang, Y; Ni, J; Qu, L; Wang, M; Yang, H | 1 |
| Callaway, S; Ceballos, C; Hunter, E; McDonough, PM; Mikic, I; Planey, S; Price, JH; Seron, T; von Massenbach, B; Watson, R; Zacharias, D; Zhang, J | 1 |
| Chouljenko, VN; Colgrove, R; Farzan, M; Iyer, A; Knipe, DM; Kousoulas, KG; Petit, CM | 1 |
| Harbour, SN; Jackson, DE; Newman, PJ; Paddock, C; Sardjono, CT; Tridandapani, S; Yip, JC | 1 |
| Arehart, EJ; Douville, KL; Gleim, SR; Hwa, J; Stitham, J | 1 |
| Hannun, YA; Tani, M | 1 |
| Jin, M; Li, S; Travis, GH; Yuan, Q | 1 |
| Bamberger, M; Bismuth, G; Carmo, AM; Castro, MA; Gonçalves, CM; Nunes, RJ; Pereira, CF | 1 |
| Fujiyoshi, Y; Hiroaki, Y; Nishikawa, K; Suzuki, H | 1 |
| Crouch, RK; Filipek, S; Jastrzebska, B; Kono, M; Lem, J; Maeda, A; Maeda, T; Müller, DJ; Palczewski, K; Park, PS; Pulawski, W; Sapra, KT | 1 |
| Berthiaume, LG; Keller, BO; Kostiuk, MA | 1 |
| Duval, M; Fromentin, R; Leclerc, D; Majeau, N; Savard, C; Tremblay, MJ | 1 |
| Gallagher, T; Shulla, A | 1 |
| Buddelmeijer, N; Young, R | 1 |
| Kinsella, BT; Mulvaney, EP; Reid, HM; Turner, EC | 1 |
| Bar, E; Gutman, O; Henis, YI; Hirsch, JA; Jürgens, G; Lewinsohn, E; Poraty, L; Richter, S; Segev, O; Sorek, N; Yalovsky, S | 1 |
| Chamberlain, LH; Gorleku, OA; Greaves, J; Salaun, C | 1 |
| Beaino, W; Trifilieff, E | 1 |
| Chen, D; Deng, J; Gong, W; Hou, J; Wang, X; Xie, Z; Yang, F; Zhao, Z | 1 |
| Geffard, M; Kubera, M; Leunis, JC; Maes, M; Mihaylova, I | 1 |
| Adibekian, A; Cravatt, BF; Martin, BR; Tully, SE; Wang, C | 1 |
| Huang, C; Makino, S; Matsuyama, S; Shirato, K; Taguchi, F; Ujike, M | 1 |
| Ahrends, R; Banerji, S; Flieger, A; Hermes, B; Lang, C; Rastew, E; Siegbrecht, E | 1 |
| Geffard, M; Kubera, M; Leunis, JC; Maes, M; Mihaylova, I; Twisk, FN | 1 |
| Fuller, W; Howie, J; Shattock, MJ; Tulloch, LB | 1 |
| Bublitz, M; Capy, P; Decottignies, P; le Maire, M; Le Maréchal, P; Montigny, C; Møller, JV; Nissen, P; Olesen, C | 1 |
| Aguilera, G; Deng, Q; Riquelme, D; Waxse, B; Zhang, J | 1 |
| Clemmer, DE; Khanal, N; Li, Z; Mukhopadhyay, S; Pejaver, V; Radivojac, P | 1 |
| Aramsangtienchai, P; Cao, J; Lin, H; Spiegelman, NA | 1 |
| Dainese, E; Dufrusine, B; Fezza, F; Maccarrone, M; Oddi, S; Scipioni, L; Selent, J; Stepniewski, TM; Totaro, A | 1 |
| Gottlieb, CD; Linder, ME | 1 |
| Fernandez, JP; Hang, HC; Molina, H; Thinon, E | 1 |
| Kumar, M; Kumar, R; Kumari, B | 1 |
| Albanesi, JP; Angert, I; Barylko, B; Chen, Y; Chen, YJ; Hennen, J; Liou, J; Mueller, JD; Sun, HQ; Taylor, CA; Yin, H | 1 |
| Delon, J; El Masri, R | 1 |
| Lin, H | 1 |
| Brügger, B; Cortizo, FG; Diakonov, EE; Helm, D; Kopp-Schneider, A; Lohbeck, J; Miller, AK; Nůsková, H; Reid, C; Sachsenheimer, T; Schneider, M; Schwenker, LS; Teleman, AA; Tiebe, M | 1 |
8 review(s) available for cysteine and palmitic acid
| Article | Year |
|---|---|
Post-translational modifications of beta subunits of voltage-dependent calcium channels.
Topics: Animals; Calcium Channels; Calcium Channels, L-Type; Cysteine; Humans; Muscle Proteins; Mutagenesis, Site-Directed; Myocardium; Palmitic Acid; Phosphorylation; Protein Conformation; Protein Folding; Protein Isoforms; Protein Processing, Post-Translational; Protein-Tyrosine Kinases; Recombinant Fusion Proteins; Structure-Activity Relationship | 1998 |
Functional domains in tetraspanin proteins.
Topics: Amino Acid Sequence; Animals; Binding Sites; Cysteine; Dimerization; Humans; Membrane Proteins; Models, Molecular; Molecular Sequence Data; Palmitic Acid; Protein Structure, Quaternary; Protein Structure, Tertiary | 2003 |
Role of palmitoylation in RGS protein function.
Topics: Amino Acid Sequence; Animals; Cell Membrane; Conserved Sequence; Cysteine; GTP Phosphohydrolases; GTP-Binding Protein alpha Subunits, Gi-Go; GTPase-Activating Proteins; Guanosine Triphosphate; Humans; Models, Molecular; Palmitic Acid; Protein Processing, Post-Translational; Protein Structure, Secondary; RGS Proteins; Signal Transduction | 2004 |
RGS17/RGSZ2 and the RZ/A family of regulators of G-protein signaling.
Topics: Animals; Calcium; Cysteine; GTP-Binding Proteins; GTPase-Activating Proteins; Humans; Models, Biological; Palmitic Acid; Protein Binding; Protein Structure, Tertiary; RGS Proteins; Signal Transduction; Subcellular Fractions; Tissue Distribution; Ubiquitin | 2006 |
Human prostacyclin receptor structure and function from naturally-occurring and synthetic mutations.
Topics: Amino Acid Sequence; Asparagine; Binding Sites; Cysteine; Models, Molecular; Molecular Sequence Data; Mutation; Nuclear Magnetic Resonance, Biomolecular; Palmitic Acid; Polymorphism, Genetic; Polymorphism, Single Nucleotide; Proline; Protein Structure, Secondary; Protein Structure, Tertiary; Receptors, Epoprostenol; Serine | 2007 |
Regulation of the cardiac Na(+) pump by palmitoylation of its catalytic and regulatory subunits.
Topics: Amino Acid Sequence; Animals; Catalytic Domain; Cysteine; Humans; Lipoylation; Models, Molecular; Molecular Sequence Data; Myocardium; Palmitic Acid; Protein Processing, Post-Translational; Protein Structure, Quaternary; Sequence Homology, Amino Acid; Sodium-Potassium-Exchanging ATPase | 2013 |
Structure and function of DHHC protein S-acyltransferases.
Topics: Acyltransferases; Animals; Cysteine; Humans; Isoenzymes; Lipoylation; Mutation; Palmitic Acid; Protein Conformation; Protein Interaction Domains and Motifs; Protein Processing, Post-Translational; Species Specificity; Substrate Specificity | 2017 |
Protein cysteine palmitoylation in immunity and inflammation.
Topics: Animals; Cysteine; Cytokines; Humans; Inflammation; Palmitic Acid; Signal Transduction | 2021 |
172 other study(ies) available for cysteine and palmitic acid
| Article | Year |
|---|---|
Effects of altering palmitylation sites on biosynthesis and function of the influenza virus hemagglutinin.
Topics: Amino Acid Sequence; Animals; Cell Fusion; Cell Line; Cysteine; Hemagglutinin Glycoproteins, Influenza Virus; Hemagglutinins, Viral; Influenza A virus; Kinetics; Molecular Sequence Data; Mutagenesis, Site-Directed; Palmitic Acid; Palmitic Acids; Trypsin; Viral Envelope Proteins | 1992 |
Palmitylation of neuromodulin (GAP-43) is not required for phosphorylation by protein kinase C.
Topics: Amino Acid Sequence; Animals; Base Sequence; CHO Cells; Cricetinae; Cysteine; GAP-43 Protein; Genetic Vectors; Kinetics; Membrane Glycoproteins; Molecular Sequence Data; Mutagenesis, Site-Directed; Nerve Tissue Proteins; Neurofilament Proteins; Oligodeoxyribonucleotides; Palmitic Acid; Palmitic Acids; Phosphorylation; Protein Kinase C; Restriction Mapping; Substrate Specificity; Time Factors; Transfection | 1992 |
Palmitylation of a G-protein coupled receptor. Direct analysis by tandem mass spectrometry.
Topics: Amino Acid Sequence; Animals; Cattle; Chromatography, High Pressure Liquid; Cyanogen Bromide; Cysteine; GTP-Binding Proteins; Mass Spectrometry; Models, Structural; Molecular Sequence Data; Palmitic Acid; Palmitic Acids; Peptide Fragments; Protein Conformation; Rhodopsin; Rod Cell Outer Segment; Thermolysin | 1992 |
Identification of palmitoylation sites on CD4, the human immunodeficiency virus receptor.
Topics: Amino Acid Sequence; Base Sequence; CD4 Antigens; Chromatography, Liquid; Cysteine; HeLa Cells; HIV; Humans; Methionine; Molecular Sequence Data; Mutagenesis; Palmitic Acid; Palmitic Acids; Plasmids; Precipitin Tests; Protein Processing, Post-Translational | 1992 |
Lung surfactant protein SP-C from human, bovine, and canine sources contains palmityl cysteine thioester linkages.
Topics: Acylation; Amino Acid Sequence; Animals; Cattle; Chromatography, Gas; Chromatography, High Pressure Liquid; Cysteine; Dithiothreitol; Dogs; Humans; Molecular Sequence Data; Palmitic Acid; Palmitic Acids; Proteolipids; Pulmonary Surfactants; Spectrum Analysis; Sulfhydryl Compounds | 1991 |
The M2 protein of influenza A virus is acylated.
Topics: Acylation; Animals; Autoradiography; Cell Line; Cysteine; Influenza A virus; Myristic Acid; Myristic Acids; Palmitic Acid; Palmitic Acids; Protein Processing, Post-Translational; Sulfur Radioisotopes; Tritium; Viral Matrix Proteins | 1991 |
Palmitylation, sulfation, and glycosylation of the alpha subunit of the sodium channel. Role of post-translational modifications in channel assembly.
Topics: Alkaloids; Animals; Brain; Cells, Cultured; Cysteine; Embryo, Mammalian; Glycoproteins; Indolizines; Ion Channels; Macromolecular Substances; Membrane Proteins; Methionine; Neurons; Palmitic Acid; Palmitic Acids; Protein Processing, Post-Translational; Rats; Sodium; Sodium Channels; Swainsonine; Tunicamycin | 1987 |
Palmitoylation of the human beta 2-adrenergic receptor. Mutation of Cys341 in the carboxyl tail leads to an uncoupled nonpalmitoylated form of the receptor.
Topics: Acylation; Adenylyl Cyclases; Cell Membrane; Cysteine; Humans; Membrane Glycoproteins; Mutation; Palmitic Acid; Palmitic Acids; Protein Processing, Post-Translational; Radioligand Assay; Receptors, Adrenergic, beta; Structure-Activity Relationship | 1989 |
Posttranslational membrane attachment and dynamic fatty acylation of a neuronal growth cone protein, GAP-43.
Topics: Acylation; Animals; Axons; Brain; Calcium; Cations, Divalent; Cell Membrane; Cerebral Cortex; Cysteine; Fatty Acids; GAP-43 Protein; Growth Substances; Membrane Proteins; Nerve Tissue Proteins; Neurons; Palmitic Acid; Palmitic Acids; Phosphoproteins; Protein Processing, Post-Translational; Rats; Rats, Inbred Strains; Solubility; Zinc | 1989 |
Posttranslational processing of p21 ras proteins involves palmitylation of the C-terminal tetrapeptide containing cysteine-186.
Topics: Animals; Cells, Cultured; Cysteine; Molecular Weight; Oncogene Proteins, Viral; Palmitic Acid; Palmitic Acids; Protein Processing, Post-Translational; Rats; Sarcoma Viruses, Murine | 1985 |
Direct identification of palmitic acid as the lipid attached to p21ras.
Topics: Animals; Cell Transformation, Neoplastic; Cells, Cultured; Cysteine; Harvey murine sarcoma virus; Mice; Myristic Acid; Myristic Acids; Oncogene Protein p21(ras); Oncogene Proteins, Viral; Palmitic Acid; Palmitic Acids; Sarcoma Viruses, Murine | 1986 |
Incorporation of myristate and palmitate into the sheep reticulocyte transferrin receptor: evidence for identical sites of labeling.
Topics: Acylation; Animals; Cell Fractionation; Centrifugation, Density Gradient; Chymotrypsin; Cysteine; Erythrocyte Membrane; Hydroxylamine; Hydroxylamines; Immunosorbent Techniques; Myristic Acid; Myristic Acids; Palmitic Acid; Palmitic Acids; Protein Biosynthesis; Receptors, Transferrin; Reticulocytes; Serine Endopeptidases; Sheep; Sulfhydryl Compounds; Tritium | 1988 |
A carboxyl-terminal cysteine residue is required for palmitic acid binding and biological activity of the ras-related yeast YPT1 protein.
Topics: Amino Acid Sequence; Animals; Base Sequence; Codon; Cysteine; Fungal Proteins; Genes; Genes, Fungal; Humans; Molecular Sequence Data; Mutation; Palmitic Acid; Palmitic Acids; Protein Binding; ras Proteins; Saccharomyces cerevisiae; Sequence Homology, Nucleic Acid | 1988 |
Chemical identification of cysteine as palmitoylation site in a transmembrane protein (Semliki Forest virus E1).
Topics: Amino Acid Sequence; Animals; Chromatography, High Pressure Liquid; Cricetinae; Cysteine; Electrophoresis, Polyacrylamide Gel; Isothiocyanates; Membrane Proteins; Molecular Sequence Data; Molecular Weight; p-Dimethylaminoazobenzene; Palmitic Acid; Palmitic Acids; Semliki forest virus; Thiocyanates | 1988 |
Two adjacent cysteine residues in the C-terminal cytoplasmic fragment of bovine rhodopsin are palmitylated.
Topics: Acylation; Animals; Cattle; Cell Membrane; Chromatography, Gas; Chromatography, High Pressure Liquid; Cysteine; Cytoplasm; Mass Spectrometry; Palmitic Acid; Palmitic Acids; Peptide Fragments; Protein Conformation; Retinal Pigments; Rhodopsin; Rod Cell Outer Segment | 1988 |
The HLA-D-associated invariant chain binds palmitic acid at the cysteine adjacent to the membrane segment.
Topics: Antibodies, Monoclonal; Cell Line; Cerulenin; Cysteine; Fatty Acids; Histocompatibility Antigens Class II; Humans; Hydroxylamine; Hydroxylamines; Immunosorbent Techniques; Palmitic Acid; Palmitic Acids; Polymorphism, Genetic; Tunicamycin | 1986 |
Ia-associated invariant chain is fatty acylated before addition of sialic acid.
Topics: Acylation; Animals; Antibodies, Monoclonal; Antigens, Differentiation, B-Lymphocyte; Cerulenin; Cysteine; Disulfides; Histocompatibility Antigens Class II; Lymphoma; Mice; Mice, Inbred BALB C; N-Acetylneuraminic Acid; Neuraminidase; Palmitic Acid; Palmitic Acids; Plasmacytoma; Protein Binding; Sialic Acids; Tunicamycin | 1985 |
Cysteines in the transmembrane region of major histocompatibility complex antigens are fatty acylated via thioester bonds.
Topics: Cysteine; Histocompatibility Antigens Class II; HLA Antigens; HLA-A Antigens; HLA-B Antigens; HLA-DR Antigens; Humans; Hydrogen-Ion Concentration; Hydroxylamine; Hydroxylamines; Major Histocompatibility Complex; Palmitic Acid; Palmitic Acids; Palmitoyl Coenzyme A; Peptide Hydrolases; Tromethamine | 1984 |
Identification of the palmitoylation site in rat myelin P0 glycoprotein.
Topics: Acylation; Amino Acid Sequence; Animals; Binding Sites; Borohydrides; Cysteine; Esters; Fatty Acids; Hydroxylamine; Hydroxylamines; In Vitro Techniques; Molecular Sequence Data; Myelin P0 Protein; Myelin Proteins; Oxidation-Reduction; Palmitic Acid; Palmitic Acids; Rats; Sciatic Nerve; Sulfhydryl Compounds | 1994 |
Biosynthesis and palmitoylation of endothelial nitric oxide synthase: mutagenesis of palmitoylation sites, cysteines-15 and/or -26, argues against depalmitoylation-induced translocation of the enzyme.
Topics: Animals; Base Sequence; Biological Transport; Blotting, Western; Bradykinin; Calcium; Cattle; Cell Fractionation; Cysteine; Cytosol; Endothelium, Vascular; Ionomycin; Membranes; Molecular Sequence Data; Mutagenesis, Site-Directed; Myristic Acid; Myristic Acids; Nitric Oxide Synthase; Palmitic Acid; Palmitic Acids; Protein Binding; Protein Processing, Post-Translational; Recombinant Proteins; Signal Transduction; Structure-Activity Relationship; Transfection | 1995 |
The role of palmitoylation of the guanine nucleotide binding protein G11 alpha in defining interaction with the plasma membrane.
Topics: Amino Acid Sequence; Animals; Base Sequence; Cell Line; Cell Membrane; Chlorocebus aethiops; Chromatography, Gel; Cysteine; Cytosol; DNA Primers; DNA, Complementary; Electrophoresis, Polyacrylamide Gel; Genetic Variation; GTP-Binding Proteins; Mice; Molecular Sequence Data; Mutagenesis, Site-Directed; Palmitic Acid; Palmitic Acids; Point Mutation; Polymerase Chain Reaction; Protein Processing, Post-Translational; Recombinant Proteins; Sequence Homology, Amino Acid; Serine; Transfection | 1995 |
Depalmitoylation of rhodopsin with hydroxylamine.
Topics: Acylation; Animals; Cattle; Cell Line; Chlorocebus aethiops; Chromatography, Affinity; Cysteine; Guanosine Triphosphate; Hydrogen-Ion Concentration; Hydrolysis; Hydroxylamine; Hydroxylamines; Isotope Labeling; Kinetics; Membrane Proteins; Mutagenesis, Site-Directed; Palmitic Acid; Palmitic Acids; Phosphates; Phosphorus Radioisotopes; Protein Processing, Post-Translational; Radioisotope Dilution Technique; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Rhodopsin; Rod Cell Outer Segment; Transfection; Tritium | 1995 |
P-selectin is acylated with palmitic acid and stearic acid at cysteine 766 through a thioester linkage.
Topics: Acylation; Amino Acid Sequence; Antigens, CD; Base Sequence; Blood Platelets; Cloning, Molecular; Cysteine; DNA; Electrophoresis, Polyacrylamide Gel; Gas Chromatography-Mass Spectrometry; Humans; Molecular Sequence Data; Oligodeoxyribonucleotides; P-Selectin; Palmitic Acid; Palmitic Acids; Platelet Membrane Glycoproteins; Polymerase Chain Reaction; Protein Processing, Post-Translational; Stearic Acids; Tritium | 1993 |
Determination of the structural requirements for palmitoylation of p63.
Topics: Amino Acid Sequence; Animals; Base Sequence; Brefeldin A; Cell Line; Chlorocebus aethiops; Cyclopentanes; Cysteine; Membrane Proteins; Molecular Sequence Data; Palmitic Acid; Palmitic Acids | 1995 |
Caveolin is palmitoylated on multiple cysteine residues. Palmitoylation is not necessary for localization of caveolin to caveolae.
Topics: Amino Acid Sequence; Animals; Caveolin 1; Caveolins; Cell Line; Cell Membrane; Cysteine; Dogs; Humans; Membrane Proteins; Molecular Sequence Data; Palmitic Acid; Palmitic Acids; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-fyn; Structure-Activity Relationship | 1995 |
Palmitoylation of G protein-coupled receptor kinase, GRK6. Lipid modification diversity in the GRK family.
Topics: Acylation; Amino Acid Sequence; Animals; Baculoviridae; Cell Line; Cell Membrane; Chlorocebus aethiops; Cysteine; Cytosol; Delayed Rectifier Potassium Channels; Electrophoresis, Polyacrylamide Gel; G-Protein-Coupled Receptor Kinases; GTP-Binding Proteins; Kidney; Molecular Sequence Data; Palmitic Acid; Palmitic Acids; Plasmids; Potassium Channels; Potassium Channels, Voltage-Gated; Protein Prenylation; Protein Processing, Post-Translational; Protein Serine-Threonine Kinases; Receptor Protein-Tyrosine Kinases; Spodoptera; Transfection | 1994 |
The low affinity neurotrophin receptor, p75LNTR, is palmitoylated by thioester formation through cysteine 279.
Topics: Acylation; Amino Acid Sequence; Animals; Cell Line; Cell Membrane; Chlorocebus aethiops; Cysteine; Esters; Mice; Mice, Inbred BALB C; Molecular Sequence Data; Palmitic Acid; Palmitic Acids; PC12 Cells; Protein Processing, Post-Translational; Rats; Receptor, Nerve Growth Factor; Receptors, Neuropeptide; Transfection | 1994 |
Palmitoylation of luteinizing hormone/human choriogonadotropin receptors in transfected cells. Abolition of palmitoylation by mutation of Cys-621 and Cys-622 residues in the cytoplasmic tail increases ligand-induced internalization of the receptor.
Topics: Amino Acid Sequence; Animals; Base Sequence; Cell Line; Cell Membrane; Chorionic Gonadotropin; Cysteine; Humans; Kidney; Kinetics; Models, Structural; Molecular Sequence Data; Mutagenesis, Site-Directed; Oligodeoxyribonucleotides; Palmitic Acid; Palmitic Acids; Protein Processing, Post-Translational; Protein Structure, Secondary; Rats; Receptors, LH; Recombinant Proteins; Transfection | 1994 |
N-terminally myristoylated Ras proteins require palmitoylation or a polybasic domain for plasma membrane localization.
Topics: Amino Acid Sequence; Animals; Base Sequence; Calcium-Calmodulin-Dependent Protein Kinases; Cell Line; Cell Membrane; Chlorocebus aethiops; Cysteine; DNA Primers; Mitogen-Activated Protein Kinase Kinases; Molecular Sequence Data; Mutagenesis, Site-Directed; Myristic Acid; Myristic Acids; Palmitic Acid; Palmitic Acids; Point Mutation; Polymerase Chain Reaction; Protein Biosynthesis; Protein Kinases; Protein Processing, Post-Translational; Proto-Oncogene Proteins p21(ras); Recombinant Proteins; Restriction Mapping; Sequence Homology, Amino Acid; Serine; Transfection | 1994 |
Lack of N terminal palmitoylation of G protein alpha subunits reduces membrane association.
Topics: Amino Acid Sequence; Animals; Cell Line; Cysteine; Cytosol; DNA, Complementary; GTP-Binding Proteins; Hydroxylamine; Hydroxylamines; Immunoblotting; Molecular Sequence Data; Mutagenesis, Site-Directed; Palmitic Acid; Palmitic Acids; Protein Processing, Post-Translational; Rats; Serine; Transfection | 1993 |
The G protein alpha s subunit incorporates [3H]palmitic acid and mutation of cysteine-3 prevents this modification.
Topics: Animals; Base Sequence; Cell Line; Cycloheximide; Cysteine; Gene Expression; GTP-Binding Proteins; Immunoblotting; Immunosorbent Techniques; Methionine; Molecular Sequence Data; Mutagenesis, Site-Directed; Palmitic Acid; Palmitic Acids; Rats; Transfection; Tritium | 1993 |
Palmitoylation of Semliki Forest virus glycoproteins in insect cells (C6/36) occurs in an early compartment and is coupled to the cleavage of the precursor p62.
Topics: Acylation; Aedes; Animals; Cell Compartmentation; Cysteine; Palmitic Acid; Palmitic Acids; Protein Precursors; Protein Processing, Post-Translational; Semliki forest virus; Vero Cells; Viral Envelope Proteins | 1993 |
Mutations of the alpha 2A-adrenergic receptor that eliminate detectable palmitoylation do not perturb receptor-G-protein coupling.
Topics: Acylation; Alanine; Allosteric Regulation; Amino Acid Sequence; Animals; Cell Line; Chromatography, Affinity; Cysteine; Dogs; Electrophoresis, Polyacrylamide Gel; Genetic Vectors; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Guanylyl Imidodiphosphate; Kidney; Kinetics; Mutagenesis, Site-Directed; Palmitic Acid; Palmitic Acids; Receptors, Adrenergic, beta; Recombinant Proteins; Serine; Swine; Transfection; Yohimbine | 1993 |
Palmitoylation of bovine opsin and its cysteine mutants in COS cells.
Topics: Amino Acid Sequence; Animals; Cattle; Cell Line; Cell Membrane; Cysteine; Electrophoresis, Polyacrylamide Gel; Eye Proteins; G-Protein-Coupled Receptor Kinase 1; Molecular Sequence Data; Mutagenesis, Site-Directed; Palmitic Acid; Palmitic Acids; Phosphorylation; Protein Kinases; Protein Processing, Post-Translational; Protein Structure, Secondary; Recombinant Proteins; Rhodopsin; Rod Opsins; Serine; Spectrophotometry; Transfection | 1993 |
Site-directed mutations in the Sindbis virus E2 glycoprotein identify palmitoylation sites and affect virus budding.
Topics: Amino Acid Sequence; Animals; Cell Line; Cysteine; DNA Mutational Analysis; Models, Biological; Molecular Sequence Data; Mutagenesis, Site-Directed; Palmitic Acid; Palmitic Acids; Phenotype; Protein Processing, Post-Translational; RNA, Viral; Sindbis Virus; Viral Envelope Proteins; Virus Replication | 1993 |
A lipoprotein signal peptide plus a cysteine residue at the amino-terminal end of the periplasmic protein beta-lactamase is sufficient for its lipid modification, processing and membrane localization in Escherichia coli.
Topics: Amino Acid Sequence; Anti-Bacterial Agents; Bacterial Outer Membrane Proteins; Bacterial Proteins; Base Sequence; beta-Lactamases; Biological Transport; Cysteine; Cytoplasm; Endopeptidases; Escherichia coli; Escherichia coli Proteins; Lipoproteins; Membrane Proteins; Molecular Sequence Data; Palmitic Acid; Palmitic Acids; Peptides; Protein Processing, Post-Translational; Protein Sorting Signals; Recombinant Fusion Proteins; Serine Endopeptidases; Substrate Specificity | 1993 |
Palmitoylation of either Cys-3 or Cys-5 is required for the biological activity of the Lck tyrosine protein kinase.
Topics: Amino Acid Sequence; Animals; Base Sequence; Cell Line; Chlorocebus aethiops; Cysteine; DNA Primers; Interleukin-3; Kinetics; Lymphocyte Activation; Lymphocyte Specific Protein Tyrosine Kinase p56(lck); Mice; Molecular Sequence Data; Mutagenesis, Site-Directed; Palmitic Acid; Palmitic Acids; Point Mutation; Polymerase Chain Reaction; Protein Processing, Post-Translational; Rats; Recombinant Proteins; Restriction Mapping; src-Family Kinases; T-Lymphocytes; Transfection | 1995 |
Mutagenesis of palmitoylation sites in endothelial nitric oxide synthase identifies a novel motif for dual acylation and subcellular targeting.
Topics: Acylation; Amino Acid Sequence; Base Sequence; Cell Compartmentation; Cell Membrane; Cells, Cultured; Cysteine; Endothelium, Vascular; Fatty Acids; Isoenzymes; Molecular Sequence Data; Mutagenesis; Myristic Acid; Myristic Acids; Nitric Oxide Synthase; Palmitic Acid; Palmitic Acids; Protein Processing, Post-Translational; Recombinant Proteins; Sequence Deletion; Structure-Activity Relationship | 1995 |
Palmitoylation of the GluR6 kainate receptor.
Topics: Alanine; Animals; Autoradiography; Base Sequence; Cell Line; Cysteine; DNA, Complementary; Embryo, Mammalian; Embryo, Nonmammalian; GluK2 Kainate Receptor; Humans; Kidney; Molecular Sequence Data; Mutagenesis, Site-Directed; Oligodeoxyribonucleotides; Open Reading Frames; Palmitic Acid; Palmitic Acids; Phosphorylation; Point Mutation; Protein Kinase C; Protein Processing, Post-Translational; Receptors, Kainic Acid; Receptors, Metabotropic Glutamate; Recombinant Proteins; Spodoptera; Transfection; Tritium | 1995 |
Cysteine-699, a possible palmitoylation site of the thyrotropin receptor, is not crucial for cAMP or phosphoinositide signaling but is necessary for full surface expression.
Topics: Amino Acid Sequence; Animals; Cell Line; Cell Membrane; Cyclic AMP; Cysteine; Molecular Sequence Data; Palmitic Acid; Palmitic Acids; Phosphatidylinositols; Protein Binding; Receptors, Thyrotropin; Signal Transduction; Thyrotropin | 1996 |
Multiple palmitoylation of synaptotagmin and the t-SNARE SNAP-25.
Topics: Acylation; Amino Acid Sequence; Calcium-Binding Proteins; Cell Fractionation; Cell Membrane; Cysteine; Cytosol; Membrane Glycoproteins; Membrane Proteins; Molecular Sequence Data; Mutation; Nerve Tissue Proteins; Palmitic Acid; Palmitic Acids; Qa-SNARE Proteins; Synaptosomal-Associated Protein 25; Synaptotagmins | 1996 |
Oligomerization of VIP21-caveolin in vitro is stabilized by long chain fatty acylation or cholesterol.
Topics: Acyl Coenzyme A; Acylation; Animals; Carrier Proteins; Caveolin 1; Caveolins; Cell Line; Cysteine; Dogs; Humans; Hydroxycholesterols; Membrane Proteins; Palmitic Acid; Palmitic Acids | 1996 |
Palmitoylated cysteine 341 modulates phosphorylation of the beta2-adrenergic receptor by the cAMP-dependent protein kinase.
Topics: Adrenergic beta-Agonists; Amino Acid Sequence; Animals; Cell Line; Cyclic AMP-Dependent Protein Kinases; Cysteine; Humans; Molecular Sequence Data; Mutagenesis, Site-Directed; Palmitic Acid; Palmitic Acids; Phosphorylation; Receptors, Adrenergic, beta-2; Recombinant Proteins; Spodoptera | 1996 |
Lipid-modified, cysteinyl-containing peptides of diverse structures are efficiently S-acylated at the plasma membrane of mammalian cells.
Topics: Acylation; Acyltransferases; Amino Acid Sequence; Animals; Cell Line; Cell Membrane; Cysteine; Enzyme Inhibitors; Golgi Apparatus; Intracellular Membranes; Lipoproteins; Mammals; Molecular Sequence Data; Palmitic Acid; Palmitic Acids; Peptides; Substrate Specificity; Tunicamycin | 1996 |
The release of the variant surface protein of Giardia to its soluble isoform is mediated by the selective cleavage of the conserved carboxy-terminal domain.
Topics: Amino Acid Sequence; Animals; Antigens, Protozoan; Antigens, Surface; Cell Membrane; Conserved Sequence; Cysteine; Giardia; Hydrolases; Kinetics; Membrane Proteins; Molecular Sequence Data; Palmitic Acid; Palmitic Acids; Protozoan Proteins; Sequence Homology, Amino Acid; Sheep; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization | 1996 |
Cytoplasmic tail length influences fatty acid selection for acylation of viral glycoproteins.
Topics: Acylation; Amino Acid Sequence; Animals; Cell Line; Cells, Cultured; Cysteine; Cytoplasm; Electrophoresis, Polyacrylamide Gel; Fatty Acids; Gammainfluenzavirus; Hemagglutinin Glycoproteins, Influenza Virus; Hemagglutinins, Viral; Membrane Proteins; Microscopy, Fluorescence; Molecular Sequence Data; Myristic Acid; Myristic Acids; Palmitic Acid; Palmitic Acids; Precipitin Tests; Recombinant Fusion Proteins; Stearic Acids; Viral Envelope Proteins | 1996 |
Fatty acylation of synaptotagmin in PC12 cells and synaptosomes.
Topics: Acylation; Amino Acid Sequence; Animals; Aplysia; Brain; Caenorhabditis elegans; Calcium-Binding Proteins; Cysteine; Decapodiformes; Drosophila; Humans; Hydroxylamine; Hydroxylamines; Membrane Glycoproteins; Molecular Sequence Data; Nerve Tissue Proteins; Palmitic Acid; Palmitic Acids; PC12 Cells; Rats; Sequence Homology, Amino Acid; Synaptosomes; Synaptotagmin I; Synaptotagmins | 1996 |
CD36 is palmitoylated on both N- and C-terminal cytoplasmic tails.
Topics: Animals; CD36 Antigens; Cell Line; Cysteine; Cytoplasm; DNA, Complementary; Electrophoresis, Polyacrylamide Gel; Flow Cytometry; Humans; Palmitic Acid; Rats; Transfection | 1996 |
Cysteines 153 and 154 of transmembrane transforming growth factor-alpha are palmitoylated and mediate cytoplasmic protein association.
Topics: Animals; CHO Cells; Cricetinae; Cysteine; Cytoplasm; Membrane Proteins; Mutagenesis, Site-Directed; Palmitic Acid; Plasmids; Transforming Growth Factor alpha | 1996 |
Partial constitutive activation of pheromone responses by a palmitoylation-site mutant of a G protein alpha subunit in yeast.
Topics: Cell Membrane; Cysteine; Esters; Fungal Proteins; GTP-Binding Protein alpha Subunits; GTP-Binding Protein alpha Subunits, Gq-G11; GTP-Binding Proteins; Guanosine Diphosphate; Heterotrimeric GTP-Binding Proteins; Membrane Proteins; Mutagenesis; Palmitic Acid; Pheromones; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Signal Transduction; Sulfhydryl Compounds | 1996 |
Fatty acylation of the rat and human asialoglycoprotein receptors. A conserved cytoplasmic cysteine residue is acylated in all receptor subunits.
Topics: Acylation; Animals; Asialoglycoprotein Receptor; Chromatography, High Pressure Liquid; Cysteine; Fatty Acids; Humans; Hydroxylamine; Hydroxylamines; Iodoacetamide; Molecular Weight; Palmitic Acid; Protein Conformation; Rats; Rats, Sprague-Dawley; Receptors, Cell Surface; Subtilisins | 1996 |
The lipoprotein VirB7 interacts with VirB9 in the membranes of Agrobacterium tumefaciens.
Topics: Agrobacterium tumefaciens; Bacterial Proteins; Cell Membrane; Cysteine; Dimerization; Electrophoresis, Polyacrylamide Gel; Lipoproteins; Membrane Proteins; Oxidation-Reduction; Palmitic Acid; Precipitin Tests; Virulence Factors | 1997 |
Rapid plasma membrane anchoring of newly synthesized p59fyn: selective requirement for NH2-terminal myristoylation and palmitoylation at cysteine-3.
Topics: 3T3 Cells; Acylation; Animals; Cell Membrane; COS Cells; Cysteine; Detergents; GAP-43 Protein; GTP-Binding Proteins; Humans; Membrane Glycoproteins; Mice; Mutation; Myristic Acid; Myristic Acids; Nerve Tissue Proteins; Octoxynol; Oncogene Protein pp60(v-src); Palmitic Acid; Polyribosomes; Protein Processing, Post-Translational; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-fyn; Proto-Oncogene Proteins pp60(c-src); Recombinant Fusion Proteins; RNA, Messenger | 1997 |
Elimination of palmitoylation sites in the human dopamine D1 receptor does not affect receptor-G protein interaction.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Acylation; Adenylyl Cyclases; Alanine; Amino Acid Sequence; Animals; Cells, Cultured; Cloning, Molecular; Cricetinae; Cysteine; Dopamine; Dopamine Agonists; GTP-Binding Proteins; Humans; Kidney; Molecular Sequence Data; Mutagenesis, Site-Directed; Palmitic Acid; Radioligand Assay; Receptors, Adrenergic, beta-2; Receptors, Dopamine D1; Sequence Alignment; Software; Transfection | 1997 |
Intrinsic signals in the unique domain target p56(lck) to the plasma membrane independently of CD4.
Topics: 3T3 Cells; Animals; Biological Transport; CD4 Antigens; CD8 Antigens; Cell Membrane; Cysteine; Fluorescent Antibody Technique, Indirect; Golgi Apparatus; HeLa Cells; Humans; Lymphocyte Specific Protein Tyrosine Kinase p56(lck); Mice; Microscopy, Electron; Palmitic Acid; Protein Sorting Signals; Protein Structure, Tertiary; src-Family Kinases; T-Lymphocytes; Transfection | 1997 |
A cysteine-3 to serine mutation of the G-protein Gi1 alpha abrogates functional activation by the alpha 2A-adrenoceptor but not interactions with the beta gamma complex.
Topics: Adenylate Cyclase Toxin; Adenylyl Cyclases; Animals; Chlorocebus aethiops; COS Cells; Cysteine; GTP-Binding Protein alpha Subunits, Gi-Go; Mutagenesis, Site-Directed; Palmitic Acid; Pertussis Toxin; Receptors, Adrenergic, alpha-2; Serine; Virulence Factors, Bordetella | 1997 |
Altered activity of palmitoylation-deficient and isoprenylated forms of the G protein-coupled receptor kinase GRK6.
Topics: Amino Acid Sequence; Amino Acid Substitution; Animals; Base Sequence; Cattle; COS Cells; Cysteine; DNA Primers; Eye Proteins; G-Protein-Coupled Receptor Kinase 1; G-Protein-Coupled Receptor Kinases; GTP-Binding Proteins; Isoproterenol; Kinetics; Liposomes; Molecular Sequence Data; Mutagenesis, Site-Directed; Palmitic Acid; Phosphatidylcholines; Phosphorylation; Polymerase Chain Reaction; Protein Kinases; Protein Prenylation; Protein Serine-Threonine Kinases; Receptor Protein-Tyrosine Kinases; Receptors, Adrenergic, beta-2; Recombinant Proteins; Retina; Rhodopsin; Sequence Deletion; Serine; Transfection | 1997 |
Characterization of the palmitoylation domain of SNAP-25.
Topics: Amino Acid Sequence; Amino Acid Substitution; Animals; Base Sequence; Cell Membrane; COS Cells; Cysteine; DNA Primers; Membrane Proteins; Mice; Molecular Sequence Data; Mutagenesis, Site-Directed; Nerve Tissue Proteins; Neurons; Palmitic Acid; Polymerase Chain Reaction; Protein Processing, Post-Translational; Recombinant Proteins; Synaptosomal-Associated Protein 25; Transfection | 1997 |
Met-Gly-Cys motif from G-protein alpha subunit cannot direct palmitoylation when fused to heterologous protein.
Topics: Amino Acid Sequence; Animals; Base Sequence; Cell Line; Cysteine; Glycine; GTP-Binding Protein alpha Subunits, Gs; Macromolecular Substances; Methionine; Myristic Acid; Palmitic Acid; Protein Biosynthesis; Protein Processing, Post-Translational; Recombinant Fusion Proteins; Spodoptera; Transcription, Genetic; Transfection; Tumor Necrosis Factor-alpha | 1998 |
Mapping fatty acid binding to beta-lactoglobulin: Ligand binding is restricted by modification of Cys 121.
Topics: Anilino Naphthalenesulfonates; Animals; Binding Sites; Cattle; Cyclic N-Oxides; Cysteine; Electron Spin Resonance Spectroscopy; Fluorescence; Fluorescent Dyes; Hydrogen-Ion Concentration; Lactoglobulins; Ligands; Methyl Methanesulfonate; Methylation; Models, Molecular; Molecular Structure; Palmitic Acid; Protein Binding; Spin Labels; Vitamin A | 1998 |
Plasma membrane localization is required for RGS4 function in Saccharomyces cerevisiae.
Topics: Amino Acid Sequence; Calcium-Calmodulin-Dependent Protein Kinases; Cell Membrane; Cysteine; Fungal Proteins; Green Fluorescent Proteins; Luminescent Proteins; Molecular Sequence Data; Palmitic Acid; Pheromones; Proteins; RGS Proteins; Saccharomyces cerevisiae; Signal Transduction; Structure-Activity Relationship | 1998 |
A cysteine-11 to serine mutant of G alpha12 impairs activation through the thrombin receptor.
Topics: Acylation; Amino Acid Sequence; Cysteine; Molecular Sequence Data; Mutagenesis, Site-Directed; Palmitic Acid; Protein Binding; Protein Processing, Post-Translational; Receptors, Thrombin; Serine; Signal Transduction | 1998 |
Membrane targeting of L-type calcium channels. Role of palmitoylation in the subcellular localization of the beta2a subunit.
Topics: Amino Acid Sequence; Animals; Anti-Bacterial Agents; Biological Transport; Brefeldin A; Calcium Channels; Calcium Channels, L-Type; Cell Compartmentation; Cyclopentanes; Cysteine; Macrolides; Molecular Sequence Data; Mutation; Palmitic Acid; Protein Processing, Post-Translational; Protein Synthesis Inhibitors; Rabbits; Rats; Recombinant Fusion Proteins; Species Specificity; src Homology Domains | 1998 |
Measles virus fusion protein is palmitoylated on transmembrane-intracytoplasmic cysteine residues which participate in cell fusion.
Topics: Acylation; Amino Acid Sequence; Animals; Base Sequence; Cell Fusion; Cell Line; Cell Membrane; Chlorocebus aethiops; Cysteine; Cytoplasm; DNA Primers; Dogs; Giant Cells; Humans; Measles virus; Molecular Sequence Data; Mutagenesis, Site-Directed; Palmitic Acid; Vero Cells; Viral Fusion Proteins | 1998 |
Identification of a cytoplasmic region of CD20 required for its redistribution to a detergent-insoluble membrane compartment.
Topics: Antibody Specificity; Antigens, CD20; Cell Compartmentation; Cell Membrane; Cysteine; Cytoplasm; Humans; Immune Sera; Membrane Proteins; Octoxynol; Palmitic Acid; Peptide Fragments; Protein Structure, Tertiary; Sequence Deletion; Solubility | 1998 |
Nonenzymatic palmitoylation at Cys 3 causes extra-activation of the alpha-subunit of the stimulatory GTP-binding protein Gs.
Topics: Acylation; Animals; Cell Line; Cysteine; GTP-Binding Protein alpha Subunits, Gs; Humans; Hydrolysis; Palmitic Acid; Recombinant Proteins; Tritium; Turkeys | 1998 |
Palmitoylation of the rat mu opioid receptor.
Topics: Amino Acid Sequence; Animals; Binding Sites; CHO Cells; Cricetinae; Cysteine; Dithiothreitol; Hydroxylamine; Kinetics; Molecular Sequence Data; Morphine; Mutagenesis, Site-Directed; Palmitic Acid; Peptide Fragments; Protein Processing, Post-Translational; Rats; Receptors, Opioid, mu; Recombinant Proteins; Transfection | 1998 |
A non-farnesylated Ha-Ras protein can be palmitoylated and trigger potent differentiation and transformation.
Topics: 3T3 Cells; Animals; Cell Differentiation; Cell Membrane; Cysteine; DNA, Complementary; Guanosine Diphosphate; Guanosine Triphosphate; Mice; Palmitic Acid; PC12 Cells; Protein Prenylation; ras Proteins; Rats; Structure-Activity Relationship; Transfection | 1999 |
Structural features of the C-terminal domain of bovine rhodopsin: a site-directed spin-labeling study.
Topics: Amino Acid Sequence; Animals; Antibodies, Monoclonal; Binding Sites; Binding Sites, Antibody; Cattle; Cysteine; Electron Spin Resonance Spectroscopy; Light; Molecular Sequence Data; Mutagenesis, Site-Directed; Palmitic Acid; Peptide Fragments; Rhodopsin; Spin Labels | 1999 |
Single-cysteine substitution mutants at amino acid positions 306-321 in rhodopsin, the sequence between the cytoplasmic end of helix VII and the palmitoylation sites: sulfhydryl reactivity and transducin activation reveal a tertiary structure.
Topics: Amino Acid Sequence; Amino Acid Substitution; Animals; Binding Sites; Cattle; COS Cells; Cysteine; Cytoplasm; Disulfides; Leucine; Light; Molecular Sequence Data; Palmitic Acid; Peptide Fragments; Protein Structure, Secondary; Protein Structure, Tertiary; Pyridines; Rhodopsin; Spectrometry, Fluorescence; Sulfhydryl Reagents; Transducin; Tyrosine | 1999 |
Palmitoylation of a conserved cysteine in the regulator of G protein signaling (RGS) domain modulates the GTPase-activating activity of RGS4 and RGS10.
Topics: Animals; Base Sequence; Cysteine; DNA Primers; DNA, Complementary; GTP-Binding Proteins; GTPase-Activating Proteins; Mutagenesis, Site-Directed; Palmitic Acid; RGS Proteins; Spodoptera | 1999 |
Palmitoylation of apolipoprotein B is required for proper intracellular sorting and transport of cholesteroyl esters and triglycerides.
Topics: Animals; Apolipoproteins B; Biological Transport; Cholesterol Esters; Chromatography, Thin Layer; Cysteine; Endoplasmic Reticulum; Fluorescent Antibody Technique, Indirect; Golgi Apparatus; Humans; Hydroxylamine; Lipids; Lipoproteins, LDL; Mutagenesis, Site-Directed; Palmitic Acid; Protein Processing, Post-Translational; Rats; Sequence Deletion; Structure-Activity Relationship; Transfection; Triglycerides; Tumor Cells, Cultured | 2000 |
Dual lipid modification motifs in G(alpha) and G(gamma) subunits are required for full activity of the pheromone response pathway in Saccharomyces cerevisiae.
Topics: Amino Acid Motifs; Animals; Cell Membrane; Cells, Cultured; Cysteine; Green Fluorescent Proteins; GTP-Binding Protein alpha Subunits; GTP-Binding Protein alpha Subunits, Gq-G11; GTP-Binding Protein gamma Subunits; Heterotrimeric GTP-Binding Proteins; Insecta; Luminescent Proteins; Palmitic Acid; Pheromones; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins | 2000 |
Cysteine 3 is not the site of in vitro palmitoylation on G(salpha).
Topics: Acylation; Cell-Free System; Cysteine; GTP-Binding Protein alpha Subunits, Gs; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Diphosphate; Mutation; Palmitic Acid; Palmitoyl Coenzyme A; Protein Conformation; Protein Processing, Post-Translational | 2000 |
Galpha 13 requires palmitoylation for plasma membrane localization, Rho-dependent signaling, and promotion of p115-RhoGEF membrane binding.
Topics: Amino Acid Sequence; Amino Acid Substitution; Animals; Cell Line; Cell Membrane; COS Cells; Cysteine; DNA-Binding Proteins; GTP-Binding Protein alpha Subunits, G12-G13; Guanine Nucleotide Exchange Factors; Heterotrimeric GTP-Binding Proteins; Humans; Luciferases; Molecular Sequence Data; Mutagenesis, Site-Directed; Nuclear Proteins; Palmitic Acid; Protein Processing, Post-Translational; Rats; Recombinant Proteins; rho GTP-Binding Proteins; Rho Guanine Nucleotide Exchange Factors; Sequence Alignment; Serum Response Factor; Signal Transduction; Transcription Factors; Transcription, Genetic; Transfection | 2000 |
A proline-rich region and nearby cysteine residues target XLalphas to the Golgi complex region.
Topics: Alternative Splicing; Amino Acid Motifs; Amino Acid Sequence; Animals; Cell Line; Chromogranins; COS Cells; Cysteine; Golgi Apparatus; Green Fluorescent Proteins; GTP-Binding Protein alpha Subunits, Gs; Heterotrimeric GTP-Binding Proteins; Humans; Immunoblotting; Intracellular Membranes; Luminescent Proteins; Membrane Proteins; Microscopy, Confocal; Microscopy, Fluorescence; Molecular Sequence Data; Nerve Tissue Proteins; Palmitic Acid; PC12 Cells; Proline; Rats; Recombinant Fusion Proteins | 2000 |
Alkylation of cysteine-containing peptides to mimic palmitoylation.
Topics: Alkylation; Amino Acid Sequence; Cysteine; Molecular Mimicry; Molecular Sequence Data; Palmitic Acid; Peptides; Protein Processing, Post-Translational | 2000 |
Acylation of Galpha(13) is important for its interaction with thrombin receptor, transforming activity and actin stress fiber formation.
Topics: Actins; Acylation; Amino Acid Sequence; Amino Acid Substitution; Animals; Binding Sites; Cell Line; Cell Membrane; Cell Transformation, Neoplastic; Cysteine; Cytoskeleton; Guanosine 5'-O-(3-Thiotriphosphate); Heterotrimeric GTP-Binding Proteins; Mice; Molecular Sequence Data; Mutation; Palmitic Acid; Protein Binding; Rats; Receptor, PAR-1; Receptors, Thrombin; rho GTP-Binding Proteins; Signal Transduction; Transfection; Tumor Stem Cell Assay | 2000 |
Localization and targeting of SCG10 to the trans-Golgi apparatus and growth cone vesicles.
Topics: Animals; Calcium-Binding Proteins; Carrier Proteins; Cysteine; Fluorescent Antibody Technique; Gene Deletion; Golgi Apparatus; Growth Cones; Intracellular Membranes; Intracellular Signaling Peptides and Proteins; Membrane Proteins; Mice; Mice, Inbred Strains; Microscopy, Immunoelectron; Microtubule Proteins; Mutagenesis; Nerve Growth Factors; Nerve Tissue Proteins; Palmitic Acid; PC12 Cells; Protein Sorting Signals; Protein Structure, Tertiary; Rats; Stathmin; Subcellular Fractions; Synaptophysin; Synaptosomal-Associated Protein 25; Transfection | 2000 |
Dynamic palmitoylation of lymphoma proprotein convertase prolongs its half-life, but is not essential for trans-Golgi network localization.
Topics: Amino Acid Substitution; Brefeldin A; Cerulenin; Cycloheximide; Cysteine; Cytosol; Enzyme Stability; Exocytosis; Fluorescent Antibody Technique, Indirect; Half-Life; Lymphoma; Membrane Microdomains; Monensin; Mutation; Palmitic Acid; Protein Processing, Post-Translational; Protein Sorting Signals; Protein Structure, Tertiary; Protein Transport; Serine Endopeptidases; Subtilisins; trans-Golgi Network; Tunicamycin | 2000 |
Epstein-Barr virus latent-infection membrane proteins are palmitoylated and raft-associated: protein 1 binds to the cytoskeleton through TNF receptor cytoplasmic factors.
Topics: Cell Line, Transformed; Cysteine; Cytoskeleton; Enzyme Activation; Herpesvirus 4, Human; Humans; JNK Mitogen-Activated Protein Kinases; Lipid Metabolism; Mitogen-Activated Protein Kinases; NF-kappa B; Palmitic Acid; Protein Binding; Protein Isoforms; Receptors, Tumor Necrosis Factor; Signal Transduction; Viral Matrix Proteins | 2001 |
The sites for fatty acylation, phosphorylation and intermolecular disulphide bond formation of influenza C virus CM2 protein.
Topics: Animals; Binding Sites; Biological Transport; Cell Membrane; Centrifugation, Density Gradient; Chlorocebus aethiops; COS Cells; Cross-Linking Reagents; Cysteine; Disulfides; Gammainfluenzavirus; Humans; Palmitic Acid; Phosphorylation; Sucrose; Viral Matrix Proteins | 2001 |
Palmitoylation-dependent control of degradation, life span, and membrane expression of the CCR5 receptor.
Topics: Amino Acid Sequence; Cell Line; Cysteine; Flow Cytometry; Half-Life; Humans; Hydrolysis; Membrane Proteins; Molecular Sequence Data; Palmitic Acid; Receptors, CCR5; Sequence Homology, Amino Acid | 2001 |
Primary sequence requirements for S-acylation of beta(2)-adrenergic receptor peptides.
Topics: Acylation; Amino Acid Sequence; Amino Acids; Cysteine; Hydrogen-Ion Concentration; Kinetics; Palmitic Acid; Peptide Fragments; Protein Processing, Post-Translational; Receptors, Adrenergic, beta-2 | 2001 |
Palmitoylation of the vasopressin V1a receptor reveals different conformational requirements for signaling, agonist-induced receptor phosphorylation, and sequestration.
Topics: Amino Acid Sequence; Animals; Base Sequence; Cell Line; CHO Cells; Cricetinae; Cysteine; DNA Primers; Humans; Molecular Sequence Data; Palmitic Acid; Phosphorylation; Protein Conformation; Receptors, Vasopressin; Sequence Homology, Amino Acid; Signal Transduction | 2001 |
The juxtamembrane lysine and arginine residues of surfactant protein C precursor influence palmitoylation via effects on trafficking.
Topics: Amino Acid Sequence; Amino Acid Substitution; Animals; Arginine; Base Sequence; Biological Transport, Active; Brefeldin A; CHO Cells; Cricetinae; Cysteine; DNA Primers; Endoplasmic Reticulum; Golgi Apparatus; Humans; Lysine; Molecular Sequence Data; Mutation; Palmitic Acid; Peptides; Pulmonary Surfactant-Associated Protein C; Pulmonary Surfactants; Recombinant Proteins; Subcellular Fractions | 2001 |
Enrichment of G-protein palmitoyltransferase activity in low density membranes: in vitro reconstitution of Galphai to these domains requires palmitoyltransferase activity.
Topics: Acyltransferases; Blotting, Western; Caveolin 1; Caveolins; Cell Line; Cell Membrane; Cyclodextrins; Cysteine; Detergents; Humans; Immunoblotting; Membrane Microdomains; Mutation; Palmitic Acid; Protein Binding; Protein Structure, Tertiary; Recombinant Proteins; Signal Transduction; Tumor Cells, Cultured | 2001 |
C-terminal domain of the Epstein-Barr virus LMP2A membrane protein contains a clustering signal.
Topics: Amino Acid Sequence; Cysteine; Membrane Microdomains; Membrane Proteins; Molecular Sequence Data; Octoxynol; Palmitic Acid; Viral Matrix Proteins | 2001 |
The 5-hydroxytryptamine(4a) receptor is palmitoylated at two different sites, and acylation is critically involved in regulation of receptor constitutive activity.
Topics: Acylation; Amino Acid Sequence; Animals; Binding Sites; Binding, Competitive; Cell Line; Cell Membrane; COS Cells; Cyclic AMP; Cysteine; DNA; Dose-Response Relationship, Drug; Guanosine 5'-O-(3-Thiotriphosphate); Immunohistochemistry; Insecta; Models, Biological; Molecular Sequence Data; Mutagenesis, Site-Directed; Mutation; Palmitic Acid; Palmitic Acids; Precipitin Tests; Protein Binding; Protein Structure, Tertiary; Receptors, Serotonin; Receptors, Serotonin, 5-HT4; Recombinant Proteins; Sequence Homology, Amino Acid; Serine; Signal Transduction; Time Factors; Transfection | 2002 |
Intracellular trafficking of the UL11 tegument protein of herpes simplex virus type 1.
Topics: Biological Transport; Cell Membrane; Cysteine; Golgi Apparatus; Humans; Membrane Proteins; Palmitic Acid; Phosphorylation; Simplexvirus; Viral Structural Proteins | 2001 |
Cholesteryl ester is transported from caveolae to internal membranes as part of a caveolin-annexin II lipid-protein complex.
Topics: Animals; Annexin A2; Biological Transport; Caveolae; Caveolin 1; Caveolins; Cell Line; Cell Membrane; CHO Cells; Cholesterol Esters; Cricetinae; Cysteine; Cytosol; Electrophoresis, Polyacrylamide Gel; Gas Chromatography-Mass Spectrometry; Humans; Immunoblotting; Immunoglobulin G; Lipid Metabolism; Lipoproteins, LDL; Mice; Mutation; Palmitic Acid; Precipitin Tests; Protein Binding; Silver Staining; Temperature; Time Factors; Transfection | 2002 |
Differential effect of brefeldin A on the palmitoylation of surfactant protein C proprotein mutants.
Topics: Alanine; Animals; Antioxidants; Brefeldin A; Cell Membrane; Cell Nucleus; CHO Cells; Cricetinae; Cysteine; Immunohistochemistry; Kinetics; Leucine; Masoprocol; Monensin; Mutation; Nocodazole; Palmitic Acid; Palmitic Acids; Peptides; Proline; Protein Processing, Post-Translational; Protein Structure, Tertiary; Protein Synthesis Inhibitors; Pulmonary Surfactants; Recombinant Proteins; Transfection | 2002 |
Structural requirements for palmitoylation of surfactant protein C precursor.
Topics: Amino Acid Sequence; Animals; Cell Membrane; CHO Cells; Cricetinae; Cysteine; Cystine; Humans; Hydroxylamine; Immunohistochemistry; Molecular Sequence Data; Mutagenesis, Site-Directed; Mutation; Palmitic Acid; Peptides; Protein Structure, Tertiary; Pulmonary Surfactant-Associated Protein C; Pulmonary Surfactants; Transfection | 2002 |
Mechanisms of regulation of phospholipase D1 and D2 by the heterotrimeric G proteins G13 and Gq.
Topics: Animals; Brain; Clostridium botulinum; COS Cells; Cysteine; DNA-Binding Proteins; Enzyme Activation; Genes, Dominant; GTP-Binding Protein alpha Subunits, G12-G13; GTP-Binding Protein alpha Subunits, Gq-G11; Heterotrimeric GTP-Binding Proteins; Mutation; Palmitic Acid; Phorbol Esters; Phospholipase D; Phosphorylation; Plasmids; Protein Binding; Protein Kinase C; Protein Processing, Post-Translational; Rats; rhoA GTP-Binding Protein; Serine; Threonine; Transfection | 2002 |
Regulation of RGS3 and RGS10 palmitoylation by GnRH.
Topics: Animals; Antineoplastic Agents, Hormonal; Blotting, Western; Buserelin; Cysteine; Electrophoresis, Polyacrylamide Gel; Gene Expression Regulation; GTP-Binding Proteins; GTPase-Activating Proteins; Humans; Kinetics; Mutagenesis, Site-Directed; Palmitic Acid; Rats; Receptors, LHRH; Repressor Proteins; Reverse Transcriptase Polymerase Chain Reaction; RGS Proteins; Signal Transduction; Sodium Fluoride | 2002 |
Differential stability of tetraspanin/tetraspanin interactions: role of palmitoylation.
Topics: Animals; Antigens, CD; Antigens, Differentiation, T-Lymphocyte; Cell Line; CHO Cells; Cricetinae; Cysteine; Detergents; Drug Stability; Humans; In Vitro Techniques; Macromolecular Substances; Membrane Glycoproteins; Membrane Proteins; Mutagenesis, Site-Directed; Palmitic Acid; Recombinant Proteins; Tetraspanin 25; Tetraspanin 28; Tetraspanin 29 | 2002 |
Spatial relationship between the prodan site, Trp-214, and Cys-34 residues in human serum albumin and loss of structure through incremental unfolding.
Topics: 2-Naphthylamine; Binding Sites; Binding, Competitive; Cysteine; Energy Transfer; Fluorescent Dyes; Hot Temperature; Humans; Palmitic Acid; Protein Conformation; Protein Denaturation; Protein Folding; Serum Albumin; Spectrometry, Fluorescence; Tryptophan; Warfarin | 2002 |
Expression of the palmitoylation-deficient CD151 weakens the association of alpha 3 beta 1 integrin with the tetraspanin-enriched microdomains and affects integrin-dependent signaling.
Topics: Animals; Antigens, CD; Binding Sites; Cell Adhesion; Cell Line; Cysteine; Extracellular Matrix; Integrin alpha3beta1; Membrane Microdomains; Membrane Proteins; Mutagenesis, Site-Directed; Palmitic Acid; Phosphorylation; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Rats; Recombinant Proteins; Sequence Deletion; Signal Transduction; Tetraspanin 24; Transfection | 2002 |
The position of cysteine relative to the transmembrane domain is critical for palmitoylation of H1, the major subunit of the human asialoglycoprotein receptor.
Topics: Alanine; Amino Acid Motifs; Amino Acid Sequence; Animals; Asialoglycoprotein Receptor; Cell Membrane; COS Cells; Cysteine; Cytoplasm; DNA, Complementary; Humans; Molecular Sequence Data; Mutation; Palmitic Acid; Palmitic Acids; Plasmids; Protein Binding; Protein Structure, Tertiary; Sequence Homology, Amino Acid; Transfection | 2002 |
The yeast DHHC cysteine-rich domain protein Akr1p is a palmitoyl transferase.
Topics: Acyltransferases; Animals; Ankyrin Repeat; Cysteine; Humans; Palmitic Acid; Palmitoyl Coenzyme A; Protein Structure, Tertiary; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Transferases | 2002 |
Subtype-specific regulation of receptor internalization and recycling by the carboxyl-terminal domains of the human A1 and rat A3 adenosine receptors: consequences for agonist-stimulated translocation of arrestin3.
Topics: Alanine; Animals; Arrestins; beta-Adrenergic Receptor Kinases; Cell Line; CHO Cells; Cricetinae; Cyclic AMP-Dependent Protein Kinases; Cysteine; Endosomes; Green Fluorescent Proteins; Humans; Kinetics; Luminescent Proteins; Mutagenesis, Site-Directed; Palmitic Acid; Phosphorylation; Protein Structure, Tertiary; Protein Transport; Purinergic P1 Receptor Agonists; Rats; Receptor, Adenosine A3; Receptors, Purinergic P1; Recombinant Fusion Proteins; Transfection | 2002 |
Palmitoylation of the human prostacyclin receptor. Functional implications of palmitoylation and isoprenylation.
Topics: Amino Acid Motifs; Amino Acid Sequence; Blotting, Western; Calcium; Cell Line; Cyclic AMP; Cysteine; Dose-Response Relationship, Drug; Enzyme Inhibitors; Gene Deletion; Humans; Ligands; Lipids; Models, Biological; Molecular Sequence Data; Mutagenesis, Site-Directed; Mutation; Palmitic Acid; Protein Binding; Protein Kinase C; Protein Prenylation; Protein Structure, Tertiary; Radioligand Assay; Receptors, Epoprostenol; Receptors, Prostaglandin; Serine; Signal Transduction; Time Factors; Transfection | 2003 |
Lipid raft distribution of CD4 depends on its palmitoylation and association with Lck, and evidence for CD4-induced lipid raft aggregation as an additional mechanism to enhance CD3 signaling.
Topics: Amino Acid Motifs; Antibodies, Monoclonal; Binding Sites; CD3 Complex; CD4 Antigens; CD8 Antigens; Cell Membrane; Cross-Linking Reagents; Cysteine; Gene Targeting; Humans; Jurkat Cells; Lymphocyte Specific Protein Tyrosine Kinase p56(lck); Membrane Microdomains; Muromonab-CD3; Mutagenesis, Site-Directed; Palmitic Acid; Phosphorylation; Plasmids; Sequence Deletion; Signal Transduction; T-Lymphocytes; Tyrosine | 2003 |
Palmitoylated peptides from the cysteine-rich domain of SNAP-23 cause membrane fusion depending on peptide length, position of cysteines, and extent of palmitoylation.
Topics: Amino Acid Sequence; Animals; Carrier Proteins; Conserved Sequence; Cysteine; Exocytosis; Humans; Kinetics; Membrane Fusion; Mice; Molecular Sequence Data; Palmitic Acid; Peptide Fragments; Qb-SNARE Proteins; Qc-SNARE Proteins; Sequence Alignment; Sequence Homology, Amino Acid; Structure-Activity Relationship | 2003 |
Palmitoylation of phospholipid scramblase 1 controls its distribution between nucleus and plasma membrane.
Topics: Active Transport, Cell Nucleus; Animals; Antigens; Carrier Proteins; Cell Line; Cell Membrane; Cell Nucleus; Cysteine; Cytokines; Humans; Membrane Proteins; Mice; Mutagenesis, Site-Directed; Palmitates; Palmitic Acid; Phospholipid Transfer Proteins; Phospholipids; Transfection; Tumor Cells, Cultured | 2003 |
Assembly and secretion of very low density lipoproteins containing apolipoprotein B48 in transfected McA-RH7777 cells. Lack of evidence that palmitoylation of apolipoprotein B48 is required for lipoprotein secretion.
Topics: Animals; Antibodies, Monoclonal; Apolipoprotein B-48; Apolipoproteins B; Cell Line; Cysteine; Dose-Response Relationship, Drug; Endoplasmic Reticulum; Golgi Apparatus; Humans; Immunohistochemistry; Lipoproteins; Lipoproteins, VLDL; Microscopy, Fluorescence; Mutagenesis, Site-Directed; Mutation; Palmitates; Palmitic Acid; Plasmids; Protein Biosynthesis; Protein Structure, Tertiary; Protein Transport; Rats; Serine; Time Factors; Transfection; Ultracentrifugation | 2003 |
Partial rescue of functional interactions of a nonpalmitoylated mutant of the G-protein G alpha s by fusion to the beta-adrenergic receptor.
Topics: Adenylyl Cyclases; Alanine; Animals; Cell Membrane; Cysteine; Gene Expression Regulation; GTP-Binding Protein alpha Subunits, Gs; Humans; Hydroxylamine; Intracellular Fluid; Mice; Mutagenesis, Site-Directed; Palmitic Acid; Protein Binding; Protein Subunits; Protein Transport; Rats; Receptors, Adrenergic, beta-2; Recombinant Fusion Proteins; Transfection; Tumor Cells, Cultured | 2003 |
Palmitoylation regulates regulator of G-protein signaling (RGS) 16 function. II. Palmitoylation of a cysteine residue in the RGS box is critical for RGS16 GTPase accelerating activity and regulation of Gi-coupled signalling.
Topics: Adenylyl Cyclase Inhibitors; Animals; Binding Sites; Caveolin 1; Caveolins; Cell Line; Cell Membrane; COS Cells; Cysteine; Escherichia coli; GTP Phosphohydrolases; GTP-Binding Protein alpha Subunits, Gi-Go; GTPase-Activating Proteins; Humans; Membrane Lipids; Mice; Models, Molecular; Mutagenesis; Palmitic Acid; Pertussis Toxin; Proteins; Rats; Recombinant Fusion Proteins; RGS Proteins; Signal Transduction; Somatostatin; Structure-Activity Relationship; Transfection | 2003 |
Palmitoylation regulates regulators of G-protein signaling (RGS) 16 function. I. Mutation of amino-terminal cysteine residues on RGS16 prevents its targeting to lipid rafts and palmitoylation of an internal cysteine residue.
Topics: Animals; beta-Cyclodextrins; Caveolin 1; Caveolins; Cell Line; Cell Membrane; COS Cells; Cyclodextrins; Cysteine; Electrophoresis, Polyacrylamide Gel; Enzyme Activation; Glutathione Transferase; GTP Phosphohydrolases; GTP-Binding Protein alpha Subunits, Gi-Go; Guanosine Triphosphate; Heterotrimeric GTP-Binding Proteins; Humans; Immunoblotting; Liver; Male; Membrane Lipids; Mice; Microscopy, Immunoelectron; Models, Molecular; Molecular Structure; Mutagenesis; Palmitic Acid; Proteins; Rats; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Recombinant Fusion Proteins; RGS Proteins; Serotonin; Transfection | 2003 |
Distinct rates of palmitate turnover on membrane-bound cellular and oncogenic H-ras.
Topics: 3T3 Cells; Acylation; Animals; Caveolin 1; Caveolins; Cell Membrane; Cysteine; Fibroblasts; Fluorescent Antibody Technique; Genes, ras; Guanosine Diphosphate; Guanosine Triphosphate; Half-Life; Hydrogen-Ion Concentration; Kinetics; Mice; Palmitic Acid; Palmitoyl-CoA Hydrolase; Proto-Oncogene Proteins p21(ras); Sonication; Transfection; Tritium | 2003 |
Palmitoylation of carboxypeptidase D. Implications for intracellular trafficking.
Topics: 3T3 Cells; Amino Acid Sequence; Animals; Biological Transport; Carboxypeptidases; Cloning, Molecular; Cysteine; Cystine; Golgi Apparatus; Humans; Mice; Microscopy, Fluorescence; Molecular Sequence Data; Mutation; Octoxynol; Palmitic Acid; Protein Binding; Protein Structure, Tertiary; Sequence Homology, Amino Acid; Time Factors; Transfection | 2003 |
Palmitoylation sites and processing of synaptotagmin I, the putative calcium sensor for neurosecretion.
Topics: Amino Acid Sequence; Animals; Biological Transport; Calcium; Calcium-Binding Proteins; Cell Line; Cysteine; DNA; Electrophoresis, Polyacrylamide Gel; Fatty Acids; Fluorescent Antibody Technique, Indirect; Glycosylation; Golgi Apparatus; Membrane Glycoproteins; Membrane Proteins; Molecular Sequence Data; Mutation; Nerve Tissue Proteins; Palmitic Acid; PC12 Cells; Precipitin Tests; Protein Binding; Rats; Sequence Homology, Amino Acid; Synaptosomal-Associated Protein 25; Synaptotagmin I; Synaptotagmins; Time Factors; Tumor Cells, Cultured | 2003 |
Palmitoylation of the V2 vasopressin receptor carboxyl tail enhances beta-arrestin recruitment leading to efficient receptor endocytosis and ERK1/2 activation.
Topics: Animals; Arrestins; beta-Arrestins; Cell Line; Cyclic AMP; Cysteine; Dose-Response Relationship, Drug; Endocytosis; Genes, Dominant; Genetic Vectors; Green Fluorescent Proteins; Humans; Immunoblotting; Luminescent Proteins; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Mutagenesis, Site-Directed; Mutation; Palmitic Acid; Phosphorylation; Plasmids; Precipitin Tests; Protein Structure, Tertiary; Rats; Receptors, Vasopressin; Time Factors | 2003 |
Multiple determinants for rapid agonist-induced internalization of a nonmammalian gonadotropin-releasing hormone receptor: a putative palmitoylation site and threonine doublet within the carboxyl-terminal tail Are critical.
Topics: Amino Acid Sequence; Animals; Arrestins; beta-Arrestins; Caveolae; Caveolin 1; Caveolins; Chickens; Clathrin-Coated Vesicles; COS Cells; Cysteine; Dynamins; Endocytosis; Gonadotropin-Releasing Hormone; Humans; Inositol Phosphates; Kidney; Molecular Sequence Data; Mutagenesis, Site-Directed; Palmitic Acid; Protein Structure, Tertiary; Receptors, LHRH; Threonine; Transfection | 2003 |
COENZYME A-INDUCED INHIBITION OF CONVERSION OF PALMITIC ACID TO KETONE BODIES IN RAT LIVER HOMOGENATES.
Topics: Adenosine Triphosphate; Antimetabolites; Caprylates; Coenzyme A; Cysteine; Cytochromes; Ergothioneine; Glutathione; Ketone Bodies; Lipid Metabolism; Liver; Mercaptoethylamines; Palmitic Acid; Pharmacology; Rats; Research | 1964 |
The 5-hydroxytryptamine(1A) receptor is stably palmitoylated, and acylation is critical for communication of receptor with Gi protein.
Topics: Amino Acid Sequence; Animals; Baculoviridae; Cell Line; CHO Cells; Cricetinae; Cyclic AMP; Cycloheximide; Cysteine; Cytoplasm; DNA; Dose-Response Relationship, Drug; Epitopes; Esters; Fatty Acids; Fluorescent Antibody Technique, Indirect; GTP-Binding Protein alpha Subunits, Gi-Go; Guanosine 5'-O-(3-Thiotriphosphate); Hydroxylamine; Insecta; Mice; Mitogen-Activated Protein Kinases; Models, Biological; Molecular Sequence Data; Mutagenesis, Site-Directed; Mutation; NIH 3T3 Cells; Palmitic Acid; Palmitic Acids; Protein Structure, Tertiary; Protein Synthesis Inhibitors; Receptor, Serotonin, 5-HT1A; Sequence Homology, Amino Acid; Signal Transduction | 2004 |
CD81 associates with 14-3-3 in a redox-regulated palmitoylation-dependent manner.
Topics: 14-3-3 Proteins; Amino Acid Motifs; Amino Acid Sequence; Animals; Antigens, CD; Blotting, Western; Cell Division; Cloning, Molecular; COS Cells; Cysteine; Cytoplasm; Electrophoresis, Polyacrylamide Gel; Hepatocytes; Humans; Hydrogen Peroxide; Jurkat Cells; Mice; Molecular Sequence Data; NIH 3T3 Cells; Oxidation-Reduction; Oxidative Stress; Oxygen; Palmitic Acid; Plasmids; Precipitin Tests; Protein Binding; Protein Isoforms; Protein Structure, Tertiary; Sequence Homology, Amino Acid; Signal Transduction; Tetraspanin 28; Transfection; Tyrosine 3-Monooxygenase | 2004 |
S-palmitoylation modulates human estrogen receptor-alpha functions.
Topics: Alanine; Blotting, Western; Cell Membrane; Cysteine; Enzyme Activation; Estrogen Receptor alpha; Gene Deletion; HeLa Cells; Humans; Hypoglycemic Agents; Immunoblotting; Luciferases; Mitogen-Activated Protein Kinases; Mutagenesis, Site-Directed; Mutation; Palmitic Acid; Plasmids; Precipitin Tests; Protein Structure, Tertiary; Receptors, Estrogen; Signal Transduction; Time Factors; Transcriptional Activation; Transfection | 2004 |
Palmitoylation regulates the clustering and cell surface stability of GABAA receptors.
Topics: Animals; COS Cells; Cysteine; gamma-Aminobutyric Acid; Hippocampus; Neural Inhibition; Neurons; Palmitic Acid; Protein Structure, Tertiary; Protein Subunits; Rats; Receptor Aggregation; Receptors, GABA-A; Synaptic Membranes; Synaptic Transmission | 2004 |
CLIPR-59 is a lipid raft-associated protein containing a cytoskeleton-associated protein glycine-rich domain (CAP-Gly) that perturbs microtubule dynamics.
Topics: Amino Acid Sequence; Animals; Antibodies, Monoclonal; Blotting, Western; Cell Membrane; Cells, Cultured; Cysteine; Cytoskeleton; Detergents; Dose-Response Relationship, Drug; Glycine; Golgi Apparatus; Green Fluorescent Proteins; HeLa Cells; Humans; Luminescent Proteins; Membrane Microdomains; Mice; Microscopy, Confocal; Microscopy, Fluorescence; Microtubule-Associated Proteins; Microtubules; Molecular Sequence Data; Mutation; Nocodazole; Palmitic Acid; Plasmids; Point Mutation; Protein Structure, Tertiary; Subcellular Fractions; Transfection | 2004 |
SMP-1, a member of a new family of small myristoylated proteins in kinetoplastid parasites, is targeted to the flagellum membrane in Leishmania.
Topics: Amino Acid Sequence; Animals; Cell Membrane; Cloning, Molecular; Cysteine; Cytoskeleton; Detergents; Epitopes; Fatty Acids; Fatty Acids, Monounsaturated; Flagella; Glycine; Immunoblotting; Ketoconazole; Kinetoplastida; Leishmania major; Lipid Metabolism; Membrane Proteins; Microscopy, Electron; Microscopy, Fluorescence; Molecular Sequence Data; Myristic Acid; Octoxynol; Palmitic Acid; Phylogeny; Polyethylene Glycols; Protein Structure, Tertiary; Sequence Homology, Amino Acid; Sphingolipids; Temperature; Tubulin | 2004 |
The human SNARE protein Ykt6 mediates its own palmitoylation at C-terminal cysteine residues.
Topics: Amino Acid Sequence; Cell Line; Cysteine; Humans; Membrane Proteins; Molecular Sequence Data; Palmitic Acid; Peptides; Protein Structure, Tertiary; R-SNARE Proteins | 2004 |
Palmitoylation of inducible nitric-oxide synthase at Cys-3 is required for proper intracellular traffic and nitric oxide synthesis.
Topics: Amino Acid Sequence; Animals; Anti-Bacterial Agents; Antifungal Agents; Biological Transport; Boron Compounds; Brefeldin A; Cell Line; Cells, Cultured; Cloning, Molecular; COS Cells; Cysteine; Escherichia coli; Fluorescent Dyes; Golgi Apparatus; Green Fluorescent Proteins; Hydroxylamine; Lysine; Mice; Molecular Sequence Data; Monensin; Mutagenesis, Site-Directed; Mutation; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Palmitic Acid; Proline; Protein Processing, Post-Translational; Recombinant Fusion Proteins; Recombinant Proteins; Serine; Time Factors; Transfection | 2004 |
Evidence that palmitoylation of carboxyl terminus cysteine residues of the human luteinizing hormone receptor regulates postendocytic processing.
Topics: Blotting, Western; Cell Line; Cell Membrane; Cysteine; Dose-Response Relationship, Drug; Endocytosis; Glycine; GTP-Binding Proteins; Humans; Immunoprecipitation; Kinetics; Ligands; Models, Biological; Mutagenesis, Site-Directed; Mutation; Palmitic Acid; Palmitic Acids; Plasmids; Protein Binding; Protein Structure, Tertiary; Receptors, LH; Time Factors; Transfection | 2005 |
The SNARE proteins SNAP-25 and SNAP-23 display different affinities for lipid rafts in PC12 cells. Regulation by distinct cysteine-rich domains.
Topics: Amino Acid Sequence; Animals; Binding Sites; Carrier Proteins; Cysteine; Green Fluorescent Proteins; Membrane Microdomains; Membrane Proteins; Mice; Molecular Sequence Data; Mutation; Nerve Tissue Proteins; Palmitic Acid; PC12 Cells; Phenylalanine; Protein Structure, Tertiary; Protein Transport; Qb-SNARE Proteins; Qc-SNARE Proteins; Rats; SNARE Proteins; Synaptosomal-Associated Protein 25; Vesicular Transport Proteins | 2005 |
Cysteine-scanning mutagenesis of muscle carnitine palmitoyltransferase I reveals a single cysteine residue (Cys-305) is important for catalysis.
Topics: Alanine; Amino Acid Sequence; Animals; Binding Sites; Blotting, Western; Carnitine; Carnitine O-Palmitoyltransferase; Catalysis; Cysteine; DNA Primers; Humans; Kinetics; Malonyl Coenzyme A; Models, Chemical; Molecular Sequence Data; Mutagenesis; Mutation; Myocardium; Palmitic Acid; Palmitoylcarnitine; Pichia; Protein Structure, Tertiary; Sequence Homology, Amino Acid; Serine | 2005 |
Palmitoylated cysteine 192 is required for RhoB tumor-suppressive and apoptotic activities.
Topics: Alanine; Amino Acid Sequence; Apoptosis; Blotting, Western; Cell Cycle Proteins; Cell Line; Cell Line, Tumor; Cell Proliferation; Coloring Agents; Cyclin-Dependent Kinase Inhibitor p21; Cysteine; DNA Primers; Genes, Tumor Suppressor; Glycine; Humans; In Situ Nick-End Labeling; Molecular Sequence Data; Mutagenesis, Site-Directed; Mutation; Palmitic Acid; Promoter Regions, Genetic; Protein Biosynthesis; Protein Prenylation; rhoA GTP-Binding Protein; rhoB GTP-Binding Protein; Sequence Homology, Amino Acid; Serine; Tetrazolium Salts; Thiazoles; Transcription Factor AP-1; Transcription, Genetic; Transfection; Transforming Growth Factor beta | 2005 |
Carboxyl tail cysteine mutants of the thyrotropin-releasing hormone receptor type 1 exhibit constitutive signaling: role of palmitoylation.
Topics: Animals; Cell Line; CHO Cells; Cricetinae; Cysteine; Female; Humans; Mutagenesis, Site-Directed; Palmitic Acid; Peptide Fragments; Receptors, Thyrotropin-Releasing Hormone; Signal Transduction; Xenopus laevis | 2005 |
Enhanced shutoff of phototransduction in transgenic mice expressing palmitoylation-deficient rhodopsin.
Topics: Amino Acid Sequence; Animals; Blotting, Western; Cysteine; Electrodes; Gene Library; Immunohistochemistry; Light; Mass Spectrometry; Mice; Mice, Transgenic; Models, Genetic; Models, Statistical; Molecular Sequence Data; Mutation; Palmitic Acid; Phosphorylation; Protein Processing, Post-Translational; Reactive Oxygen Species; Receptors, G-Protein-Coupled; Retina; Reverse Transcriptase Polymerase Chain Reaction; Rhodopsin; RNA; Time Factors | 2005 |
Influence of administration route on tumor uptake and biodistribution of etoposide loaded solid lipid nanoparticles in Dalton's lymphoma tumor bearing mice.
Topics: Animals; Antineoplastic Agents, Phytogenic; Chelating Agents; Cysteine; Drug Carriers; Etoposide; Humans; Injections, Intraperitoneal; Injections, Intravenous; Injections, Subcutaneous; Liposomes; Lymphoma; Mice; Mice, Inbred BALB C; Microscopy, Electron, Scanning; Palmitic Acid; Particle Size; Pentetic Acid; Radionuclide Imaging; Radiopharmaceuticals; Tin Compounds; Tissue Distribution | 2005 |
Palmitoylation at Cys574 is essential for MT1-MMP to promote cell migration.
Topics: Amino Acid Motifs; Animals; Caveolae; Cell Movement; Chlorocebus aethiops; CHO Cells; Clathrin; COS Cells; Cricetinae; Cysteine; Matrix Metalloproteinase 14; Matrix Metalloproteinases; Matrix Metalloproteinases, Membrane-Associated; Mice; Palmitic Acid; Protein Processing, Post-Translational | 2005 |
Wild-type-like viral replication potential of human immunodeficiency virus type 1 envelope mutants lacking palmitoylation signals.
Topics: Amino Acid Sequence; Amino Acid Substitution; Base Sequence; Binding Sites; Cysteine; DNA Primers; Gene Products, env; HIV-1; Humans; Palmitic Acid; Plasmids; Reference Values; Sequence Deletion; Serine; Virus Replication | 2005 |
Transforming activity of the Rho family GTPase, Wrch-1, a Wnt-regulated Cdc42 homolog, is dependent on a novel carboxyl-terminal palmitoylation motif.
Topics: Amino Acid Motifs; Amino Acid Sequence; Animals; Biotin; Blotting, Western; cdc42 GTP-Binding Protein; Cell Adhesion; Cell Membrane; Cell Proliferation; Cysteine; Cytosol; Endosomes; Esters; Green Fluorescent Proteins; Mice; Microscopy, Fluorescence; Molecular Sequence Data; Mutagenesis, Site-Directed; Mutation; NIH 3T3 Cells; Palmitic Acid; Protein Binding; Protein Structure, Tertiary; Recombinant Proteins; rho GTP-Binding Proteins; Sequence Homology, Amino Acid; Signal Transduction; Transfection | 2005 |
A novel palmitoyl acyl transferase controls surface protein palmitoylation and cytotoxicity in Giardia lamblia.
Topics: Acyltransferases; Amino Acid Motifs; Amino Acid Sequence; Animals; Antibodies, Protozoan; Antigens, Protozoan; Cell Membrane; Computational Biology; Conserved Sequence; Cysteine; Genome, Protozoan; Giardia lamblia; Molecular Sequence Data; Molecular Weight; Open Reading Frames; Palmitic Acid; Protein Processing, Post-Translational; Protozoan Proteins; RNA, Antisense | 2005 |
Palmitoylation of the EGFR ligand Spitz by Rasp increases Spitz activity by restricting its diffusion.
Topics: Acyltransferases; Animals; Base Sequence; Biological Transport, Active; Cell Line; Cell Membrane; Cysteine; DNA; Drosophila; Drosophila Proteins; Epidermal Growth Factor; ErbB Receptors; Female; Genes, Insect; In Vitro Techniques; Ligands; Male; Membrane Proteins; Models, Biological; Mutagenesis, Site-Directed; Mutation; Ovary; Palmitic Acid; Recombinant Proteins; Transfection; Wings, Animal | 2006 |
Two di-leucine motifs regulate trafficking of mucolipin-1 to lysosomes.
Topics: Alanine; Amino Acid Motifs; Amino Acid Sequence; Amino Acid Substitution; Cysteine; Cytosol; Endocytosis; Fluorescent Antibody Technique, Indirect; Green Fluorescent Proteins; HeLa Cells; Humans; Leucine; Lysosomes; Microscopy, Confocal; Models, Chemical; Molecular Sequence Data; Mutagenesis, Site-Directed; Palmitic Acid; Protein Structure, Tertiary; Protein Transport; Recombinant Proteins; Transient Receptor Potential Channels; TRPM Cation Channels | 2006 |
Palmitoylation of huntingtin by HIP14 is essential for its trafficking and function.
Topics: Acyltransferases; Adaptor Proteins, Signal Transducing; Amino Acid Sequence; Animals; Animals, Newborn; Carrier Proteins; Cells, Cultured; Cerebral Cortex; Chlorocebus aethiops; COS Cells; Cysteine; Down-Regulation; Humans; Huntingtin Protein; Inclusion Bodies; Mice; Mice, Transgenic; Mutation; Nerve Tissue Proteins; Neurons; Nuclear Proteins; Palmitic Acid; Peptides; Protein Processing, Post-Translational; Protein Transport; Rats; Trinucleotide Repeat Expansion | 2006 |
Palmitoylation determines the function of Vac8 at the yeast vacuole.
Topics: Cell Membrane; Cysteine; Lipoproteins; Membrane Proteins; Mutation; Palmitic Acid; Protein Processing, Post-Translational; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; src Homology Domains; Vacuoles; Vesicular Transport Proteins | 2006 |
Unique self-palmitoylation activity of the transport protein particle component Bet3: a mechanism required for protein stability.
Topics: Animals; Arginine; Cell Line; Cricetinae; Cysteine; Humans; Models, Molecular; Palmitic Acid; Palmitoyl Coenzyme A; Protein Binding; Protein Denaturation; Protein Structure, Tertiary; Temperature; Vesicular Transport Proteins | 2006 |
Palmitoylation and its effect on the GTPase-activating activity and conformation of RGS2.
Topics: Circular Dichroism; Cysteine; Fluorescence; GTP-Binding Protein alpha Subunits, Gq-G11; GTPase-Activating Proteins; Mutagenesis, Site-Directed; Mutant Proteins; Palmitic Acid; Protein Processing, Post-Translational; Protein Structure, Secondary; RGS Proteins; Solutions; Tryptophan | 2006 |
A live cell, image-based approach to understanding the enzymology and pharmacology of 2-bromopalmitate and palmitoylation.
Topics: Amino Acid Motifs; Amino Acid Sequence; Bacterial Proteins; Cysteine; Cytoplasm; Green Fluorescent Proteins; Humans; Image Processing, Computer-Assisted; Inhibitory Concentration 50; Lipids; Luminescent Proteins; Microscopy, Fluorescence; Models, Chemical; Molecular Sequence Data; Palmitates; Palmitic Acid; Signal Transduction | 2006 |
Palmitoylation of the cysteine-rich endodomain of the SARS-coronavirus spike glycoprotein is important for spike-mediated cell fusion.
Topics: Amino Acid Sequence; Animals; Cell Fusion; Cell Membrane; Chlorocebus aethiops; Cysteine; Immunohistochemistry; Isotope Labeling; Membrane Fusion; Membrane Glycoproteins; Molecular Sequence Data; Mutagenesis, Site-Directed; Palmitic Acid; Protein Processing, Post-Translational; Severe acute respiratory syndrome-related coronavirus; Spike Glycoprotein, Coronavirus; Tritium; Vero Cells; Viral Envelope Proteins | 2007 |
Palmitoylation at Cys595 is essential for PECAM-1 localisation into membrane microdomains and for efficient PECAM-1-mediated cytoprotection.
Topics: Actin Cytoskeleton; Animals; Antigens, CD; Apoptosis; Blood Platelets; Cell Line; Cholesterol; Cysteine; Cytoplasm; Endothelial Cells; Etoposide; Genes, Reporter; Green Fluorescent Proteins; Humans; In Vitro Techniques; Membrane Microdomains; Mutation; Palmitic Acid; Platelet Activation; Platelet Endothelial Cell Adhesion Molecule-1; Platelet Membrane Glycoproteins; Protein Binding; Protein Processing, Post-Translational; Protein Structure, Tertiary; Protein Transport; Receptors, IgG; Recombinant Fusion Proteins; Signal Transduction; Transfection | 2006 |
Neutral sphingomyelinase 2 is palmitoylated on multiple cysteine residues. Role of palmitoylation in subcellular localization.
Topics: Catalytic Domain; Cell Line, Tumor; Cell Membrane; Cysteine; Humans; Palmitic Acid; Protein Transport; Sphingomyelin Phosphodiesterase; Subcellular Fractions | 2007 |
Role of LRAT on the retinoid isomerase activity and membrane association of Rpe65.
Topics: Absorption; Acyltransferases; Animals; Carrier Proteins; Cattle; Cell Membrane; cis-trans-Isomerases; Cysteine; Eye Proteins; Humans; Light; Mass Spectrometry; Mice; Palmitates; Palmitic Acid; Pigment Epithelium of Eye | 2007 |
Protein interactions between CD2 and Lck are required for the lipid raft distribution of CD2.
Topics: Animals; CD2 Antigens; Cell Line, Tumor; Cell Membrane; Cysteine; Humans; Jurkat Cells; Lymphocyte Specific Protein Tyrosine Kinase p56(lck); Membrane Microdomains; Mice; Palmitic Acid; Rats; Rats, Wistar; T-Lymphocytes; Thymoma | 2008 |
Formation of aquaporin-4 arrays is inhibited by palmitoylation of N-terminal cysteine residues.
Topics: Amino Acid Sequence; Amino Acid Substitution; Animals; Aquaporin 4; Cell Membrane; CHO Cells; Cricetinae; Cricetulus; Cysteine; Freeze Fracturing; Molecular Sequence Data; Mutant Proteins; Palmitic Acid; Protein Isoforms; Protein Structure, Quaternary; Rats; Sequence Deletion; Sodium Dodecyl Sulfate; Structure-Activity Relationship; Transfection | 2008 |
Modulation of molecular interactions and function by rhodopsin palmitylation.
Topics: Animals; Chlorocebus aethiops; COS Cells; Cysteine; Light; Mice; Mice, Inbred C57BL; Models, Molecular; Molecular Conformation; Palmitic Acid; Protein Binding; Protein Structure, Tertiary; Rhodopsin; Rod Cell Outer Segment; Transducin | 2009 |
Non-radioactive detection of palmitoylated mitochondrial proteins using an azido-palmitate analogue.
Topics: Acyl Coenzyme A; Acylation; Animals; Azides; Chromatography; Cysteine; Lipoylation; Mass Spectrometry; Mitochondria, Liver; Mitochondrial Proteins; Palmitic Acid; Phosphines; Rats; Rats, Sprague-Dawley | 2009 |
Palmitoylation of hepatitis C virus core protein is important for virion production.
Topics: Cell Line; Cell Membrane; Cysteine; Endoplasmic Reticulum; Genome, Viral; Genotype; Hepacivirus; Humans; Microscopy, Fluorescence; Mutagenesis, Site-Directed; Mutation; Palmitic Acid; Protein Sorting Signals; Viral Core Proteins; Virion | 2009 |
Role of spike protein endodomains in regulating coronavirus entry.
Topics: Amino Acid Sequence; Animals; Coronavirus; Cysteine; Fibroblasts; HeLa Cells; Humans; Lipids; Membrane Glycoproteins; Mice; Molecular Sequence Data; Palmitic Acid; Protein Binding; Protein Structure, Tertiary; Spike Glycoprotein, Coronavirus; Viral Envelope Proteins | 2009 |
The essential Escherichia coli apolipoprotein N-acyltransferase (Lnt) exists as an extracytoplasmic thioester acyl-enzyme intermediate.
Topics: Acylation; Acyltransferases; Apolipoproteins; Cysteine; DNA, Bacterial; Escherichia coli; Escherichia coli Proteins; Glycerophospholipids; Immunoblotting; Kinetics; Palmitic Acid; Plasmids; Sulfhydryl Compounds | 2010 |
Interaction of the human prostacyclin receptor with Rab11: characterization of a novel Rab11 binding domain within alpha-helix 8 that is regulated by palmitoylation.
Topics: Computational Biology; Cysteine; Humans; Leucine; Palmitic Acid; Palmitic Acids; Prostaglandins; Protein Binding; Protein Structure, Secondary; Protein Structure, Tertiary; Protein Transport; rab GTP-Binding Proteins; Receptors, Epoprostenol; Receptors, G-Protein-Coupled; Valine | 2010 |
An S-acylation switch of conserved G domain cysteines is required for polarity signaling by ROP GTPases.
Topics: Acylation; Arabidopsis; Arabidopsis Proteins; Cell Membrane; Cell Polarity; Cysteine; Lipid Metabolism; Membrane Microdomains; Models, Molecular; Monomeric GTP-Binding Proteins; Palmitic Acid; Protein Structure, Tertiary; Recombinant Fusion Proteins; Signal Transduction; Stearic Acids | 2010 |
Palmitoylation of the SNAP25 protein family: specificity and regulation by DHHC palmitoyl transferases.
Topics: Amino Acid Sequence; Animals; Cell Membrane; Cysteine; Gene Expression Regulation, Enzymologic; Golgi Apparatus; Humans; Molecular Sequence Data; Palmitic Acid; PC12 Cells; Protein Isoforms; Qb-SNARE Proteins; Qc-SNARE Proteins; Rats; Sequence Homology, Amino Acid; Synaptosomal-Associated Protein 25; Vesicular Transport Proteins | 2010 |
Thiopalmitoylated peptides from the peripheral nervous system myelin p0 protein: synthesis, characterization, and neuritogenic properties.
Topics: Animals; Circular Dichroism; Cysteine; Male; Myelin P0 Protein; Neurons; Palmitic Acid; Peptides; Peripheral Nervous System; Rats; Rats, Inbred Lew; Sulfhydryl Compounds | 2010 |
Acyl-biotinyl exchange chemistry and mass spectrometry-based analysis of palmitoylation sites of in vitro palmitoylated rat brain tubulin.
Topics: Amino Acid Sequence; Animals; Bacterial Proteins; Binding Sites; Biotin; Brain; Cysteine; Lipoylation; Mass Spectrometry; Molecular Sequence Data; Palmitic Acid; Protein Engineering; Proteomics; Rats; Sequence Analysis; Signal Transduction; Tubulin | 2010 |
IgM-mediated autoimmune responses directed against multiple neoepitopes in depression: new pathways that underpin the inflammatory and neuroprogressive pathophysiology.
Topics: Acetylcholine; Adult; Aged; Antibody Formation; Autoimmunity; Case-Control Studies; Cysteine; Depression; Depressive Disorder; DNA Damage; Epitopes; Fatigue; Fatty Acids; Female; Humans; Immunoglobulin M; Inflammation; Lipid Peroxidation; Male; Middle Aged; Myristic Acid; Negotiating; Nitric Oxide; Oxidative Stress; Palmitic Acid; Severity of Illness Index | 2011 |
Global profiling of dynamic protein palmitoylation.
Topics: Animals; Cysteine; Fatty Acids, Unsaturated; Lipase; Lipoylation; Mass Spectrometry; Mice; Organophosphonates; Palmitic Acid; Protein Processing, Post-Translational; Serine Endopeptidases; Thiolester Hydrolases | 2011 |
Two palmitylated cysteine residues of the severe acute respiratory syndrome coronavirus spike (S) protein are critical for S incorporation into virus-like particles, but not for M-S co-localization.
Topics: Animals; Chlorocebus aethiops; Coronavirus M Proteins; COS Cells; Cysteine; Membrane Glycoproteins; Mice; Palmitic Acid; Severe Acute Respiratory Syndrome; Severe acute respiratory syndrome-related coronavirus; Spike Glycoprotein, Coronavirus; Viral Envelope Proteins; Viral Matrix Proteins; Virion; Virus Assembly | 2012 |
Zinc metalloproteinase ProA directly activates Legionella pneumophila PlaC glycerophospholipid:cholesterol acyltransferase.
Topics: Acyltransferases; Amino Acid Sequence; Bacterial Proteins; Binding Sites; Blotting, Western; Catalytic Domain; Cholesterol; Cysteine; Enzyme Activation; Gene Knockout Techniques; Legionella pneumophila; Metalloproteases; Molecular Sequence Data; Mutation; Palmitic Acid; Propionates; Sequence Homology, Amino Acid; Sterols; Substrate Specificity; Zinc | 2012 |
IgM-mediated autoimmune responses directed against anchorage epitopes are greater in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) than in major depression.
Topics: Adult; Amino Acids; Analysis of Variance; Autoimmune Diseases; Cysteine; Depressive Disorder, Major; Enzyme-Linked Immunosorbent Assay; Epitopes; Fatigue Syndrome, Chronic; Female; Humans; Immunoglobulin M; Least-Squares Analysis; Male; Middle Aged; Myristic Acid; Nitric Oxide; Palmitic Acid; Phenylalanine | 2012 |
S-palmitoylation and s-oleoylation of rabbit and pig sarcolipin.
Topics: Amino Acid Sequence; Animals; Biological Evolution; Crystallography, X-Ray; Cysteine; Gene Expression; Hydroxylamine; Kinetics; Lipoylation; Models, Molecular; Molecular Sequence Data; Muscle Proteins; Muscle, Skeletal; Oleic Acid; Palmitic Acid; Phenylalanine; Phylogeny; Protein Processing, Post-Translational; Proteolipids; Rabbits; Sarcoplasmic Reticulum; Sarcoplasmic Reticulum Calcium-Transporting ATPases; Sequence Alignment; Species Specificity; Swine; Thermodynamics | 2014 |
Helix 8 of the ligand binding domain of the glucocorticoid receptor (GR) is essential for ligand binding.
Topics: Amino Acid Sequence; Animals; Cell Membrane; Conserved Sequence; Corticosterone; Cysteine; Dexamethasone; Dose-Response Relationship, Drug; HSP90 Heat-Shock Proteins; Humans; Ligands; Lipoylation; Luciferases; Molecular Sequence Data; Mutant Proteins; Mutation; Palmitic Acid; Protein Binding; Protein Structure, Secondary; Protein Structure, Tertiary; Protein Transport; Rats; Receptors, Glucocorticoid; Repetitive Sequences, Amino Acid; Sequence Alignment; Structure-Activity Relationship; Transcription, Genetic; Tritium | 2015 |
Position of Proline Mediates the Reactivity of S-Palmitoylation.
Topics: Cysteine; Lipoylation; Models, Molecular; Molecular Dynamics Simulation; Palmitic Acid; Peptides; Proline; Protein Processing, Post-Translational | 2015 |
Topics: A549 Cells; Acetyltransferases; Acyltransferases; Cell Movement; Cysteine; Human Umbilical Vein Endothelial Cells; Humans; Intracellular Signaling Peptides and Proteins; Junctional Adhesion Molecule C; Jurkat Cells; Lipoylation; Palmitic Acid; Protein Processing, Post-Translational; Tight Junctions | 2017 |
Palmitoylation of cysteine 415 of CB
Topics: Caveolin 1; Cell Line; Cholesterol; Cysteine; HEK293 Cells; Humans; Ligands; Lipoylation; Membrane Microdomains; Molecular Dynamics Simulation; Mutation; Palmitic Acid; Protein Binding; Protein Conformation; Protein Interaction Maps; Receptor, Cannabinoid, CB1 | 2017 |
Selective Enrichment and Direct Analysis of Protein S-Palmitoylation Sites.
Topics: Acylation; Animals; Binding Sites; Cysteine; Fatty Acids; Humans; Hydroxylamine; Lipoylation; Mass Spectrometry; Membrane Proteins; Palmitic Acid; Protein Processing, Post-Translational; Proteomics; RNA-Binding Proteins; Staining and Labeling | 2018 |
Prediction of Rare Palmitoylation Events in Proteins.
Topics: Algorithms; Cysteine; Glycine; Humans; Lipoylation; Palmitic Acid; Position-Specific Scoring Matrices; Protein Processing, Post-Translational; Proteins; Proteome; Serine; Support Vector Machine | 2018 |
Myristoylation-Dependent Palmitoylation of the Receptor Tyrosine Kinase Adaptor FRS2α.
Topics: Adaptor Proteins, Signal Transducing; Cell Line, Tumor; Cysteine; Golgi Apparatus; Green Fluorescent Proteins; HEK293 Cells; Humans; Lipoylation; Membrane Microdomains; Membrane Proteins; Mutation; Myristic Acid; Palmitic Acid; Spectrometry, Fluorescence | 2019 |
[An abnormal palmitoylation arising from a mutation of CDC42 results in a severe autoinflammatory syndrome].
Topics: Amino Acid Substitution; Arginine; Autoimmune Diseases; cdc42 GTP-Binding Protein; Cysteine; Humans; Inflammation; Lipoylation; Mutation, Missense; Palmitic Acid; Syndrome | 2020 |
Competition for cysteine acylation by C16:0 and C18:0 derived lipids is a global phenomenon in the proteome.
Topics: Acylation; Cysteine; HEK293 Cells; HeLa Cells; Humans; Palmitic Acid; Proteome; Stearic Acids | 2023 |