cysteine and osimertinib

cysteine has been researched along with osimertinib in 4 studies

Research

Studies (4)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	0 (0.00)	29.6817
2010's	3 (75.00)	24.3611
2020's	1 (25.00)	2.80

Authors

Authors	Studies
Ballard, P; Cantarini, MV; Collier, J; Dickinson, PA; Frewer, P; Martin, S; Pickup, K	1
Aye, Y; Long, MJC	1
Almaden, C; Barbas, S; Behenna, D; Brodsky, O; Cravatt, BF; Dix, MM; Ferre, R; Gajiwala, KS; Hayward, MM; Kath, JC; Lazear, MR; Lu, S; Niessen, S; Planken, S; Potter, ZE; Ryan, K	1
Chen, S; Fan, XX; Gong, S; Hu, X; Li, N; Wu, JL; Zhuo, Y	1

Reviews

1 review(s) available for cysteine and osimertinib

Article	Year
Privileged Electrophile Sensors: A Resource for Covalent Drug Development. Cell chemical biology, 2017, Jul-20, Volume: 24, Issue:7 Topics: Acrylamides; Aniline Compounds; Animals; Catalytic Domain; Cysteine; Drug Design; Enzyme Inhibitors; ErbB Receptors; Humans; Isoenzymes; Piperazines; Proto-Oncogene Proteins c-akt; Reactive Oxygen Species	2017

Trials

1 trial(s) available for cysteine and osimertinib

Article	Year
Metabolic Disposition of Osimertinib in Rats, Dogs, and Humans: Insights into a Drug Designed to Bind Covalently to a Cysteine Residue of Epidermal Growth Factor Receptor. Drug metabolism and disposition: the biological fate of chemicals, 2016, Volume: 44, Issue:8 Topics: Acrylamides; Adult; Aged; Aniline Compounds; Animals; Antineoplastic Agents; Binding Sites; Biotransformation; Carcinoma, Non-Small-Cell Lung; Cysteine; Cytochrome P-450 CYP3A; Dogs; Drug Administration Schedule; ErbB Receptors; Feces; Female; Hepatocytes; Humans; Lung Neoplasms; Male; Mice; Middle Aged; Piperazines; Protein Binding; Protein Kinase Inhibitors; Rats, Wistar; Serum Albumin, Human; Tissue Distribution	2016

Article

Year

Metabolic Disposition of Osimertinib in Rats, Dogs, and Humans: Insights into a Drug Designed to Bind Covalently to a Cysteine Residue of Epidermal Growth Factor Receptor.

Drug metabolism and disposition: the biological fate of chemicals, 2016, Volume: 44, Issue:8

Topics: Acrylamides; Adult; Aged; Aniline Compounds; Animals; Antineoplastic Agents; Binding Sites; Biotransformation; Carcinoma, Non-Small-Cell Lung; Cysteine; Cytochrome P-450 CYP3A; Dogs; Drug Administration Schedule; ErbB Receptors; Feces; Female; Hepatocytes; Humans; Lung Neoplasms; Male; Mice; Middle Aged; Piperazines; Protein Binding; Protein Kinase Inhibitors; Rats, Wistar; Serum Albumin, Human; Tissue Distribution

2016

Other Studies

2 other study(ies) available for cysteine and osimertinib

Article	Year
Proteome-wide Map of Targets of T790M-EGFR-Directed Covalent Inhibitors. Cell chemical biology, 2017, Nov-16, Volume: 24, Issue:11 Topics: 5'-Nucleotidase; Acrylamides; Aniline Compounds; Animals; Cathepsins; Cell Line, Tumor; Checkpoint Kinase 2; Cysteine; ErbB Receptors; GPI-Linked Proteins; HEK293 Cells; Humans; Liver; Lysosomes; Mice; Mice, Inbred C57BL; Mutagenesis, Site-Directed; Piperazines; Protein Kinase Inhibitors; Proteome; Proteomics; Rhodamines; Transplantation, Heterologous	2017
Quantification of Osimertinib and Metabolite-Protein Modification Reveals Its High Potency and Long Duration of Effects on Target Organs. Chemical research in toxicology, 2021, 11-15, Volume: 34, Issue:11 Topics: Acrylamides; Aniline Compounds; Animals; Cattle; Chromatography, Liquid; Chymotrypsin; Cysteine; Female; Humans; Hydrolysis; Liver; Male; Microsomes, Liver; Molecular Structure; Rats; Rats, Sprague-Dawley; Tandem Mass Spectrometry	2021

Article

Year

Proteome-wide Map of Targets of T790M-EGFR-Directed Covalent Inhibitors.

Cell chemical biology, 2017, Nov-16, Volume: 24, Issue:11

Topics: 5'-Nucleotidase; Acrylamides; Aniline Compounds; Animals; Cathepsins; Cell Line, Tumor; Checkpoint Kinase 2; Cysteine; ErbB Receptors; GPI-Linked Proteins; HEK293 Cells; Humans; Liver; Lysosomes; Mice; Mice, Inbred C57BL; Mutagenesis, Site-Directed; Piperazines; Protein Kinase Inhibitors; Proteome; Proteomics; Rhodamines; Transplantation, Heterologous

2017

Quantification of Osimertinib and Metabolite-Protein Modification Reveals Its High Potency and Long Duration of Effects on Target Organs.

Chemical research in toxicology, 2021, 11-15, Volume: 34, Issue:11

Topics: Acrylamides; Aniline Compounds; Animals; Cattle; Chromatography, Liquid; Chymotrypsin; Cysteine; Female; Humans; Hydrolysis; Liver; Male; Microsomes, Liver; Molecular Structure; Rats; Rats, Sprague-Dawley; Tandem Mass Spectrometry

2021