Compounds > cysteine

cysteine and monomethyl auristatin e

cysteine has been researched along with monomethyl auristatin e in 7 studies

Research

Studies (7)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's2 (28.57)29.6817
2010's5 (71.43)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Alley, SC; Andreyka, J; Carter, P; Francisco, JA; Hamblett, KJ; Kim, K; McDonagh, CF; Stone, I; Turcott, E; Webster, JB; Westendorf, L1
Bhakta, S; Chen, Y; Clark, S; Dennis, MS; Duenas, E; Flagella, K; Gorrell, J; Junutula, JR; Katta, V; Kim, A; Lee Wong, W; Lee, CC; Leipold, DD; Lowman, HB; Lu, Y; Mallet, W; McDorman, K; Meng, YG; Ng, C; Polakis, P; Raab, H; Ross, S; Scheller, RH; Simpson, M; Sliwkowski, MX; Spencer, SD; Tsai, SP; Vandlen, R; Venook, R; Weir, S; Yang, J1
McFee, WA; Salas-Solano, O; Valliere-Douglass, JF1
Liu-Shin, L; Ratnaswamy, G; Wiggins, B; Yamaguchi, H1
Bezabeh, B; Christie, RJ; Dimasi, N; Fleming, R; Gao, C; Harper, J; Joseph, A; Mao, S; Wang, Q; Woods, R; Wu, H; Xu, ZQ1
Krzyscik, MA; Lobocki, M; Otlewski, J; Sokolowska-Wedzina, A; Szlachcic, A; Zakrzewska, M1
Bhakta, J; Bhakta, S; Bos, AB; Cook, R; Dela Cruz-Chuh, J; Erickson, H; Farahi, F; Fourie-O'Donohue, A; Junutula, JR; Kozak, KR; Liu, Y; Ng, C; Ohri, R; Pillow, TH; Polakis, P; Raab, H; Tsai, SP; Vandlen, R; Wei, B; Wong, AW1

Other Studies

7 other study(ies) available for cysteine and monomethyl auristatin e

ArticleYear
Engineered antibody-drug conjugates with defined sites and stoichiometries of drug attachment.
    Protein engineering, design & selection : PEDS, 2006, Volume: 19, Issue:7

    Topics: Animals; Antibodies, Monoclonal; Antineoplastic Agents; Base Sequence; Binding Sites; Cysteine; Disulfides; Immunoconjugates; Ki-1 Antigen; Ligands; Maximum Tolerated Dose; Mice; Oligopeptides; Protein Engineering; Serine; Solvents; Transplantation, Heterologous; Tumor Cells, Cultured

2006
Site-specific conjugation of a cytotoxic drug to an antibody improves the therapeutic index.
    Nature biotechnology, 2008, Volume: 26, Issue:8

    Topics: Animals; Antibodies, Monoclonal; Antibodies, Neoplasm; Antibody Specificity; Antineoplastic Agents; Binding Sites; CA-125 Antigen; Cell Line, Tumor; Chemistry, Pharmaceutical; Cysteine; Cytotoxins; Female; Humans; Immunotoxins; Macaca fascicularis; Membrane Proteins; Mice; Mutagenesis, Site-Directed; Oligopeptides; Ovarian Neoplasms; Rats; Rats, Sprague-Dawley; Sulfhydryl Compounds

2008
Native intact mass determination of antibodies conjugated with monomethyl Auristatin E and F at interchain cysteine residues.
    Analytical chemistry, 2012, Mar-20, Volume: 84, Issue:6

    Topics: Animals; Antibodies, Monoclonal; CHO Cells; Cricetinae; Cysteine; Immunoconjugates; Immunoglobulin G; Mass Spectrometry; Oligopeptides; Recombinant Proteins

2012
Characterization of cysteine-linked conjugation profiles of immunoglobulin G1 and immunoglobulin G2 antibody-drug conjugates.
    Journal of pharmaceutical sciences, 2015, Volume: 104, Issue:4

    Topics: Ado-Trastuzumab Emtansine; Antibodies, Monoclonal, Humanized; Brentuximab Vedotin; Calorimetry, Differential Scanning; Chemistry, Pharmaceutical; Chromatography, High Pressure Liquid; Chromatography, Reverse-Phase; Cross-Linking Reagents; Cysteine; Drug Stability; Electrophoresis, Capillary; Hydrophobic and Hydrophilic Interactions; Immunoconjugates; Immunoglobulin G; Immunoglobulin Heavy Chains; Immunoglobulin Light Chains; Mass Spectrometry; Maytansine; Oligopeptides; Peptide Mapping; Protein Stability; Technology, Pharmaceutical; Temperature; Trastuzumab

2015
Stabilization of cysteine-linked antibody drug conjugates with N-aryl maleimides.
    Journal of controlled release : official journal of the Controlled Release Society, 2015, Dec-28, Volume: 220, Issue:Pt B

    Topics: Antibodies, Monoclonal; Antineoplastic Agents; Chemistry, Pharmaceutical; Cross-Linking Reagents; Cysteine; Drug Stability; Hydrolysis; Immunoconjugates; Kinetics; Maleimides; Models, Chemical; Models, Molecular; Oligopeptides; Protein Conformation; Protein Stability; Sulfhydryl Compounds

2015
High-Yield Site-Specific Conjugation of Fibroblast Growth Factor 1 with Monomethylauristatin E via Cysteine Flanked by Basic Residues.
    Bioconjugate chemistry, 2017, 07-19, Volume: 28, Issue:7

    Topics: Amino Acid Motifs; Animals; Antineoplastic Agents; Binding Sites; Cell Death; Cell Line, Tumor; Cysteine; Drug Delivery Systems; Endocytosis; Fibroblast Growth Factor 1; Humans; Oligopeptides; Receptor, Fibroblast Growth Factor, Type 1

2017
High-Throughput Cysteine Scanning To Identify Stable Antibody Conjugation Sites for Maleimide- and Disulfide-Based Linkers.
    Bioconjugate chemistry, 2018, 02-21, Volume: 29, Issue:2

    Topics: Animals; Antineoplastic Agents, Immunological; Cysteine; Disulfides; Drug Stability; High-Throughput Screening Assays; Humans; Immunoconjugates; Maleimides; Models, Molecular; Mutagenesis, Site-Directed; Oligopeptides; Protein Aggregates; Protein Stability; Rats; Trastuzumab

2018