cysteine has been researched along with methotrexate in 62 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 7 (11.29) | 18.7374 |
| 1990's | 13 (20.97) | 18.2507 |
| 2000's | 19 (30.65) | 29.6817 |
| 2010's | 20 (32.26) | 24.3611 |
| 2020's | 3 (4.84) | 2.80 |
| Authors | Studies |
|---|---|
| Bennett, CD; Williams, MN | 1 |
| Chrin, LR; Jaffe, JJ | 1 |
| Hilton, MA; Kmetz, DR; Patel, CC | 1 |
| Barrueco, JR; O'Leary, DF; Sirotnak, FM | 1 |
| Czarnomska, A; Danysz, A; Naciazek-Wieniawska, A; Soltysiak-Pawluczuk, D | 1 |
| Frank, N; Osswald, H | 1 |
| Baggott, JE; Morgan, SL; Refsum, H; Ueland, PM | 1 |
| Billiau, A; Dijkmans, R; Heremans, H | 1 |
| Allen, RH; Broxson, EH; Kolhouse, JF; Stabler, SP; Stork, LC | 1 |
| Danenberg, PV; Heidelberger, C; Langenbach, RJ | 1 |
| Fan, CC; Huennekens, FM; Vitols, KS | 1 |
| Brooks, P; Conaghan, PG | 1 |
| Brooks, P; Conaghan, PG; Girgis, L | 1 |
| Rafter, GW | 1 |
| Falzone, CJ; Iwakura, M; Jones, BE; Matthews, CR | 1 |
| Asano, G; Koda, M; Nakamura, H; Yoshino, S | 1 |
| Arakawa, M; Hasegawa, H; Nakano, M; Nishi, S; Saito, T; Ueno, M | 1 |
| Ahonen, AK; Harila-Saari, AH; Himanen, AS; Lanning, BM; Pääkkö, EL; Pyhtinen, J; Torniainen, PJ; Vainionpää, LK | 1 |
| Bottiglieri, T; Farrow, A; Griener, JC; Hyland, K; Kamen, BA; Quinn, CT | 1 |
| Bottiglieri, T; Griener, JC; Kamen, BA; Quinn, CT | 1 |
| Hefferton, D; Rahman, P; Robb, D | 1 |
| Aono, H; Hirano, D; Ishigami, S; Nagashima, M; Sasano, M; Takai, M; Wauke, K; Yoshino, S | 1 |
| Hanaoka, R; Hanyuda, M; Ide, H; Kaga, S; Kasama, T; Miwa, Y; Negishi, M; Shiozawa, F | 1 |
| Flintoff, WF; Sadlish, H; Williams, FM | 1 |
| Garfield, S; Gottesman, MM; Liang, XJ; Shen, DW | 1 |
| Gomita, Y; Kawasaki, Y; Moriyama, M; Shibata, K | 1 |
| Kawabata, D; Mimori, T | 1 |
| Abali, EE; Banerjee, D; Bertino, JR; Menon, LG; Mishra, PJ; Peters, R; Skacel, N | 1 |
| Aoyama, M; Asai, K; Fukuoka, M; Kobayashi, M; Kusabe, T; Otsuka, T; Tanikawa, T; Waguri-Nagaya, Y | 1 |
| Amano, K; Kameda, H; Sekiguchi, N; Takeuchi, T | 1 |
| Hara, M; Inoue, E; Iwatani, M; Kamatani, N; Nakajima, A; Nakamura, T; Tomatsu, T; Yamanaka, H | 1 |
| Nakamura, K; Nakashima, T; Ochi, S; Oda, H; Suematsu, A; Tajiri, Y; Taka, J; Takayanagi, H; Tanaka, S | 1 |
| Matsuda, T; Ohtsubo, H | 1 |
| Saito, E; Suwa, A; Suzuki, Y; Wakabayashi, T | 1 |
| Fujimura, M; Kasahara, K; Nakao, S; Nakatsumi, Y; Tambo, Y; Yasui, M | 1 |
| Arimitsu, J; Hagihara, K; Hirano, T; Kawai, M; Kawase, I; Kuwahara, Y; Nakanishi, K; Narazaki, M; Ogata, A; Shima, Y; Tanaka, T; Terabe, F | 1 |
| Hirohata, S; Tomita, T; Yanagida, T; Yoshikawa, H | 1 |
| Yamanaka, H | 1 |
| Mimori, T; Yukawa, N | 1 |
| Komase, Y; Sakaida, H; Takemura, T | 1 |
| Amasaki, Y; Fujisaku, A; Ichikawa, K; Mukai, M; Ohnishi, K; Ohsaki, H; Sagawa, A; Shimizu, M; Yasuda, I | 1 |
| Kawai, S; Miyasaka, N; Takeuchi, T; Tanaka, Y; Yamamoto, K | 1 |
| Koyama, Y; Ohta, T; Shiraishi, H; Uchino, A | 1 |
| Aghasadeghi, MR; Ardestani, MS; Barghi, Z; Cohan, RA; Hedayati, MH; Inanlou, DN; Khanahmad, H; Madadkar-Sobhani, A; Norouzian, D; Roohvand, F | 1 |
| Amano, H; Kageyama, M; Kempe, K; Kusaoi, M; Matsudaira, R; Matsushita, M; Morimoto, S; Nawata, M; Ogasawara, M; Onuma, S; Sekiya, F; Tada, K; Takasaki, Y; Tamura, N; Toyama, S; Yamaji, K | 1 |
| Ichikawa, N; Yamanaka, H | 1 |
| Kageyama, M; Kempe, K; Kon, T; Kusaoi, M; Matsudaira, R; Matsushita, M; Ogasawara, M; Onuma, S; Sekiya, F; Sugimoto, K; Tada, K; Takasaki, Y; Tamura, N; Yamaji, K | 1 |
| Aono, H; Okamoto, M; Sasano, M; Seki, I; Setoguchi, C; Tsuji, F | 1 |
| Suzuki, Y | 1 |
| Tamura, N | 1 |
| Tanaka, E; Yamanaka, H | 1 |
| Amano, K; Kameda, H; Kishimoto, M; Kurasawa, T; Nagasawa, H; Takeuchi, T | 1 |
| Hou, Z; Matherly, LH; Wilson, MR | 1 |
| Abe, C; Funahashi, K; Katayama, K; Kondo, M; Matsubara, T; Matsuno, H; Okada, M; Sagawa, A; Sakai, Y; Yamasaki, K | 1 |
| Alizadeh, AM; Barar, J; Davaran, S; Johari-Ahar, M; Omidi, Y; Rashidi, MR | 1 |
| Abraham, P; Natarajan, K | 1 |
| Cooper, I; Fridkin, M; Shechter, Y | 1 |
| Nerthigan, Y; Pandey, S; Sharma, AK; Wu, HF | 1 |
| Ishizaki, J; Kitagawa, K; Nakano, C; Sai, Y; Suga, Y | 1 |
| Aluri, S; Fiser, A; Goldman, ID; Lin, K; Najmi, M; Zhan, HQ; Zhao, R | 1 |
| Cui, YX; Dong, WC; Feng, JY; Guo, JL; Jiang, Y; Wu, XK; Zhang, CX; Zhang, ZQ; Zhao, MQ | 1 |
| Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K | 1 |
11 review(s) available for cysteine and methotrexate
| Article | Year |
|---|---|
Disease-modifying antirheumatic drugs, including methotrexate, gold, antimalarials, and D-penicillamine.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Antimalarials; Antirheumatic Agents; Arthritis, Rheumatoid; Clinical Trials as Topic; Cysteine; Drug Therapy, Combination; Gold; Humans; Methotrexate; Penicillamine; Sulfasalazine | 1995 |
Disease-modifying antirheumatic drugs, including methotrexate, sulfasalazine, gold, antimalarials, and penicillamine.
Topics: Age Factors; Antimalarials; Arthritis, Rheumatoid; Clinical Trials as Topic; Cysteine; Digestive System; Gold; Humans; Liver; Methotrexate; Penicillamine; Sulfasalazine | 1994 |
[Drug-induced renal disorders in patients with rheumatoid arthritis].
Topics: Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Arthritis, Rheumatoid; Cyclosporine; Cysteine; Humans; Kidney Diseases; Methotrexate; ortho-Aminobenzoates | 1996 |
[Disease modifying anti-rheumatic drugs (DMARDs): an overview].
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Benzopyrans; Cysteine; Evidence-Based Medicine; Gold Sodium Thiomalate; Humans; Isoxazoles; Leflunomide; Meta-Analysis as Topic; Methotrexate; Randomized Controlled Trials as Topic; Sulfasalazine; Sulfonamides | 2005 |
[Effective combination therapy of TNF antagonists with DMARDs].
Topics: Adalimumab; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Azathioprine; Cysteine; Drug Therapy, Combination; Etanercept; Humans; Hydroxychloroquine; Immunoglobulin G; Infliximab; Isoxazoles; Leflunomide; Methotrexate; Receptors, Tumor Necrosis Factor; Sulfasalazine; Tumor Necrosis Factor-alpha | 2007 |
[Adverse effects of conventional DMARDs and biologic DMARDs].
Topics: Antibodies, Monoclonal; Antirheumatic Agents; Chemical and Drug Induced Liver Injury; Cysteine; Drug Eruptions; Drug Hypersensitivity; Hematologic Diseases; Humans; Immune System Diseases; Infliximab; Isoxazoles; Kidney Diseases; Leflunomide; Lung Diseases; Methotrexate | 2007 |
[Antirheumatic agents for treatment of rheumatoid arthritis].
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Cysteine; Gold Sodium Thiomalate; Humans; Isoxazoles; Leflunomide; Methotrexate; Pharmacogenetics; Randomized Controlled Trials as Topic; Remission Induction; Sulfasalazine; Time Factors | 2008 |
[Effect of disease modifying anti-rheumatic drugs on radiographic progression in rheumatoid arthritis].
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Cyclosporine; Cysteine; Disease Progression; Drug Therapy, Combination; Gold Sodium Thiomalate; Humans; Isoxazoles; Leflunomide; Methotrexate; Penicillamine; Radiography; Randomized Controlled Trials as Topic; Sulfasalazine; Tacrolimus | 2009 |
[ Bone and cartilage destruction in RA and its intervention. Disease-modifying antirheumatic drugs].
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Bone and Bones; Cartilage; Clinical Trials as Topic; Cysteine; Humans; Isoxazoles; Joints; Leflunomide; Methotrexate; Sulfasalazine; Tacrolimus | 2012 |
[DMARDs (disease-modifying antirheumatic drugs)].
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Cysteine; Humans; Japan; Methotrexate; Sulfasalazine; Tacrolimus | 2013 |
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk | 2016 |
5 trial(s) available for cysteine and methotrexate
| Article | Year |
|---|---|
Homocysteine levels in patients with rheumatoid arthritis treated with low-dose methotrexate.
Topics: Arthritis, Rheumatoid; Cysteine; Double-Blind Method; Female; Folic Acid; Homocysteine; Humans; Male; Methotrexate | 1991 |
Efficacy profile of bucillamine in rheumatoid arthritis patients in a large observational cohort study, IORRA.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Cohort Studies; Cysteine; Drug Therapy, Combination; Female; Health Status; Humans; Joints; Male; Methotrexate; Middle Aged; Pain; Prednisolone; Prospective Studies; Remission Induction; Severity of Illness Index; Sulfasalazine | 2006 |
A multicentre trial of bucillamine in the treatment of early rheumatoid arthritis (SNOW study).
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Arthritis, Rheumatoid; Child; Cysteine; Early Diagnosis; Female; Humans; Male; Methotrexate; Middle Aged; Patient Dropouts; Remission Induction; Treatment Outcome; Young Adult | 2011 |
Efficacy and safety of additional use of tacrolimus in patients with early rheumatoid arthritis with inadequate response to DMARDs--a multicenter, double-blind, parallel-group trial.
Topics: Adult; Antirheumatic Agents; Arthritis, Rheumatoid; Cysteine; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Immunosuppressive Agents; Joints; Male; Methotrexate; Middle Aged; Severity of Illness Index; Sulfasalazine; Tacrolimus; Treatment Outcome | 2011 |
Addition of another disease-modifying anti-rheumatic drug to methotrexate reduces the flare rate within 2 years after infliximab discontinuation in patients with rheumatoid arthritis: an open, randomized, controlled trial.
Topics: Adult; Aged; Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Cysteine; Disease Progression; Drug Therapy, Combination; Female; Humans; Infliximab; Male; Methotrexate; Middle Aged; Treatment Outcome; Young Adult | 2014 |
46 other study(ies) available for cysteine and methotrexate
| Article | Year |
|---|---|
Effect of cysteine modification on dihydrofolate reductase from a methotrexate-resistant strain of Escherichia coli B. Identification of modified residues.
Topics: Chelating Agents; Circular Dichroism; Copper; Cysteine; Dithionitrobenzoic Acid; Drug Resistance, Microbial; Escherichia coli; Mercaptoethanol; Methotrexate; Phenylmercuric Acetate; Protein Conformation; Tetrahydrofolate Dehydrogenase | 1977 |
10-Formyltetrahydrofolate synthetase activity in normal and brugia pahangi-infected Aedes aegypti.
Topics: Aedes; Animals; Brugia; Cysteine; Female; Formate-Tetrahydrofolate Ligase; Kinetics; Ligases; Magnesium; Male; Methotrexate; Molecular Weight; Quaternary Ammonium Compounds; Suramin; Temperature | 1979 |
Plasma amino acids during high-dose methotrexate-citrovorum "rescue".
Topics: Adult; Amino Acids; Cysteine; Humans; Kinetics; Leucovorin; Male; Methotrexate; Osteosarcoma; Phenylalanine | 1976 |
Metabolic turnover of methotrexate polyglutamates in lysosomes derived from S180 cells. Definition of a two-step process limited by mediated lysosomal permeation of polyglutamates and activating reduced sulfhydryl compounds.
Topics: Animals; beta-N-Acetylhexosaminidases; Biological Transport; Cysteine; gamma-Glutamyl Hydrolase; Hydrogen-Ion Concentration; Kinetics; Lysosomes; Mercaptoethanol; Methotrexate; Mice; Models, Biological; Oxidation-Reduction; Polyglutamic Acid; Sarcoma 180; Sulfhydryl Compounds | 1992 |
Effects of thiol compounds on methotrexate uptake by murine lymphocytes from thymus and thymic lymphosarcoma.
Topics: Animals; Biological Transport, Active; Cell Membrane Permeability; Cysteine; Glutathione; Methotrexate; Mice; Mice, Inbred Strains; Oxidation-Reduction; Sulfhydryl Compounds; T-Lymphocytes; Thymus Neoplasms | 1992 |
Sacrosine- and prolinedithiocarbamate pretreatment increases the therapeutic efficacy of doxorubicin, methotrexate, teniposide, mitoxantrone or cyclohexylchloroethylnitrosourea in leukemia L1210.
Topics: Animals; Antineoplastic Agents; Cysteine; Doxorubicin; Drug Synergism; Female; Leukemia L1210; Lomustine; Methotrexate; Mice; Mice, Inbred DBA; Mitoxantrone; Proline; Sarcosine; Teniposide; Thiocarbamates | 1990 |
Heterogeneity of Chinese hamster ovary cell-produced recombinant murine interferon-gamma.
Topics: Animals; Cell Line; Cricetinae; Cricetulus; Cysteine; Electrophoresis, Polyacrylamide Gel; Female; Glycosylation; Interferon-gamma; Methionine; Methotrexate; Mice; Molecular Weight; Ovary; Poly A; Recombinant Proteins; RNA; RNA, Messenger | 1987 |
Changes in plasma methionine and total homocysteine levels in patients receiving methotrexate infusions.
Topics: Adolescent; Adult; Burkitt Lymphoma; Child; Cysteine; Homocysteine; Humans; Infusions, Intravenous; Kinetics; Methionine; Methotrexate; Models, Theoretical; Osteosarcoma; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 1989 |
Structures of reversible and irreversible complexes of thymidylate synthetase and fluorinated pyrimidine nucleotides.
Topics: Amides; Binding Sites; Binding, Competitive; Carbon Radioisotopes; Cysteine; Deoxyribonucleotides; Drug Resistance, Microbial; Fluorine; Iodoacetates; Kinetics; Lacticaseibacillus casei; Methotrexate; Methyltransferases; Models, Chemical; Peptide Fragments; Protein Binding; Protein Denaturation; Spectrophotometry, Ultraviolet; Structure-Activity Relationship; Tetrahydrofolates; Thymidylate Synthase; Tritium; Trypsin; Uracil Nucleotides | 1974 |
Inhibition of dihydrofolate reductase by methotrexate: a new look at an old problem.
Topics: Animals; Catalysis; Cells, Cultured; Cysteine; Folic Acid Antagonists; Histidine; Kinetics; Leukemia L1210; Methotrexate; Mice; NADP; Structure-Activity Relationship | 1980 |
Plasma thiols, copper and rheumatoid arthritis.
Topics: Animals; Arthritis, Rheumatoid; Copper; Cysteine; Glutathione; Homocysteine; Humans; Methionine; Methotrexate; Models, Biological; Sulfhydryl Compounds | 1994 |
Collapse of parallel folding channels in dihydrofolate reductase from Escherichia coli by site-directed mutagenesis.
Topics: Circular Dichroism; Cysteine; Escherichia coli; Flow Cytometry; Folic Acid Antagonists; Kinetics; Magnetic Resonance Spectroscopy; Methotrexate; Mutagenesis, Site-Directed; NADP; Protein Conformation; Protein Folding; Tetrahydrofolate Dehydrogenase; Thermodynamics; Urea | 1993 |
[Effects of disease modifying antirheumatic drugs (DMARDs) and DEX on IL-1 beta and IL-6 production by IL-1 beta stimulated synovial culture cells].
Topics: Anti-Inflammatory Agents; Antirheumatic Agents; Cells, Cultured; Cysteine; Depression, Chemical; Dexamethasone; Gold Sodium Thiomalate; Humans; Interleukin-1; Interleukin-6; Methotrexate; Ribonucleosides; Sulfasalazine; Synovial Membrane; Tumor Necrosis Factor-alpha | 1996 |
Brain perfusion after treatment of childhood acute lymphoblastic leukemia.
Topics: Adolescent; Antimetabolites, Antineoplastic; Brain; Child; Child, Preschool; Cranial Irradiation; Cysteine; Female; Humans; Magnetic Resonance Imaging; Male; Methotrexate; Neurologic Examination; Organotechnetium Compounds; Oximes; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Technetium Tc 99m Exametazime; Tomography, Emission-Computed, Single-Photon | 1997 |
Elevation of homocysteine and excitatory amino acid neurotransmitters in the CSF of children who receive methotrexate for the treatment of cancer.
Topics: Antimetabolites, Antineoplastic; Central Nervous System; Child; Chromatography, High Pressure Liquid; Cysteine; Excitatory Amino Acids; Homocysteine; Humans; Methotrexate; Neoplasms; Neurotransmitter Agents; Retrospective Studies | 1997 |
Methotrexate, homocysteine, and seizures.
Topics: Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Cysteine; Epilepsy, Tonic-Clonic; Homocysteine; Humans; Infant; Male; Methotrexate; Neurotransmitter Agents; Precursor B-Cell Lymphoblastic Leukemia-Lymphoma; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 1998 |
Increased MDR1 P-glycoprotein expression in methotrexate resistance: comment on the article by Yudoh et al.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cysteine; Drug Interactions; Drug Resistance, Multiple; Humans; Methotrexate; Sulfasalazine; Th1 Cells | 2000 |
Effects of combinations of anti-rheumatic drugs on the production of vascular endothelial growth factor and basic fibroblast growth factor in cultured synoviocytes and patients with rheumatoid arthritis.
Topics: Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Arthritis, Rheumatoid; C-Reactive Protein; Cells, Cultured; Cysteine; Dexamethasone; Drug Synergism; Drug Therapy, Combination; Endothelial Growth Factors; Fibroblast Growth Factor 2; Gold Sodium Thiomalate; Humans; In Vitro Techniques; Lipopolysaccharides; Lymphokines; Methotrexate; Sulfasalazine; Synovial Membrane; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors | 2000 |
[A case of rheumatoid arthritis complicated with a pneumonitis during concomitant treatment with methotrexate and bucillamine].
Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Arthritis, Rheumatoid; Cysteine; Female; Humans; Methotrexate; Pneumonia | 2002 |
The region between transmembrane domains 1 and 2 of the reduced folate carrier forms part of the substrate-binding pocket.
Topics: Alanine; Amino Acid Sequence; Animals; Bacterial Proteins; Biotin; Biotinylation; Carrier Proteins; Cell Membrane; Cricetinae; Cysteine; Cytosol; Folic Acid; Green Fluorescent Proteins; Kinetics; Luminescent Proteins; Membrane Transport Proteins; Methotrexate; Molecular Sequence Data; Mutagenesis, Site-Directed; Protein Binding; Protein Conformation; Protein Structure, Tertiary; Recombinant Fusion Proteins; Reduced Folate Carrier Protein; RNA; Streptolysins | 2003 |
Mislocalization of membrane proteins associated with multidrug resistance in cisplatin-resistant cancer cell lines.
Topics: Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biotin; Carbon Radioisotopes; Carboplatin; Carrier Proteins; Cell Membrane; Cisplatin; Cysteine; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Endoplasmic Reticulum Chaperone BiP; Folate Receptors, GPI-Anchored; HeLa Cells; Humans; KB Cells; Lysosomes; Methionine; Methotrexate; Receptors, Cell Surface; Succinimides; Sulfur Radioisotopes; Triiodobenzoic Acids; Tritium | 2003 |
[Examination of the escape phenomenon in disease modifying antirheumatic drugs].
Topics: Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Blood Sedimentation; C-Reactive Protein; Cysteine; Drug Therapy, Combination; Female; Humans; Male; Methotrexate; Middle Aged; Phenylacetates; Recurrence; Secondary Prevention; Sulfasalazine | 2005 |
Identification of amino acids required for the functional up-regulation of human dihydrofolate reductase protein in response to antifolate Treatment.
Topics: Amino Acids; Animals; Binding Sites; Blotting, Western; Catalysis; Cell Survival; CHO Cells; Cloning, Molecular; Cricetinae; Cysteine; DNA Primers; Folic Acid Antagonists; Gene Expression Regulation, Enzymologic; Glutamic Acid; Glutathione Transferase; Green Fluorescent Proteins; Humans; Inhibitory Concentration 50; Kinetics; Leucine; Methotrexate; Microscopy, Fluorescence; Models, Biological; Mutagenesis, Site-Directed; Mutation; NADP; Protein Biosynthesis; Recombinant Fusion Proteins; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Serine; Spectrophotometry; Tetrahydrofolate Dehydrogenase; Time Factors; Transcription, Genetic; Transfection; Up-Regulation | 2005 |
The inhibitory effect of disease-modifying anti-rheumatic drugs and steroids on gliostatin/platelet-derived endothelial cell growth factor production in human fibroblast-like synoviocytes.
Topics: Adrenal Cortex Hormones; Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Cells; Cells, Cultured; Cysteine; Dexamethasone; Elbow; Female; Fibroblasts; Humans; Knee; Methotrexate; Middle Aged; Organogold Compounds; Orthopedic Procedures; Penicillamine; Phenylacetates; Sulfasalazine; Synovial Membrane; Thymidine Phosphorylase | 2005 |
Efficacy and safety of bucillamine, a D-penicillamine analogue, in patients with active rheumatoid arthritis.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; C-Reactive Protein; Cysteine; Female; Humans; Joints; Male; Methotrexate; Middle Aged; Retrospective Studies; Severity of Illness Index; Treatment Outcome | 2006 |
Scientific basis for the efficacy of combined use of antirheumatic drugs against bone destruction in rheumatoid arthritis.
Topics: Animals; Antirheumatic Agents; Arthritis, Rheumatoid; Bone Resorption; Cell Differentiation; Cells, Cultured; Coculture Techniques; Cysteine; Dose-Response Relationship, Drug; Drug Therapy, Combination; Methotrexate; Mice; Mice, Inbred C57BL; NFATC Transcription Factors; Osteoclasts; RANK Ligand; Sulfasalazine | 2007 |
Eosinophilic pneumonia (EP) associated with rheumatoid arthritis in which drug-induced eosinophilic pneumonia could be ruled out.
Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Arthritis, Rheumatoid; Cysteine; Diagnosis, Differential; Glucocorticoids; Humans; Male; Methotrexate; Prednisolone; Pulmonary Eosinophilia | 2008 |
Etanercept improved primary biliary cirrhosis associated with rheumatoid arthritis.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Arthritis, Rheumatoid; Cysteine; Drug Therapy, Combination; Etanercept; Female; Humans; Immunoglobulin G; Liver Cirrhosis, Biliary; Methotrexate; Middle Aged; Prednisolone; Receptors, Tumor Necrosis Factor; Treatment Outcome; Withholding Treatment | 2009 |
Differential influences of bucillamine and methotrexate on the generation of fibroblast-like cells from bone marrow CD34+ cells of rheumatoid arthritis patients.
Topics: Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Antigens, CD34; Antirheumatic Agents; Arthritis, Rheumatoid; Bone Marrow Cells; Culture Media; Cysteine; Female; Fibroblasts; Fluorescent Antibody Technique; Humans; Ilium; Immunosuppressive Agents; Indicators and Reagents; Matrix Metalloproteinase 1; Methotrexate; Middle Aged; Stem Cells; Vimentin | 2009 |
Organizing pneumonia in a patient with rheumatoid arthritis treated with etanercept.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Cryptogenic Organizing Pneumonia; Cysteine; Drug Therapy, Combination; Etanercept; Female; Humans; Immunoglobulin G; Methotrexate; Middle Aged; Radiography, Thoracic; Receptors, Tumor Necrosis Factor; Treatment Outcome | 2010 |
Etanercept in combination with conventional disease-modifying antirheumatic drugs (DMARDs) in the treatment of rheumatoid arthritis patients intolerant to methotrexate.
Topics: Adult; Aged; Aged, 80 and over; Antirheumatic Agents; Arthritis, Rheumatoid; Cysteine; Drug Substitution; Drug Therapy, Combination; Etanercept; Female; Glucocorticoids; Humans; Immunoglobulin G; Joints; Male; Methotrexate; Middle Aged; Pain Measurement; Receptors, Tumor Necrosis Factor; Recovery of Function; Retrospective Studies; Severity of Illness Index; Sulfasalazine; Treatment Failure | 2012 |
Design, modeling, expression, and chemoselective PEGylation of a new nanosize cysteine analog of erythropoietin.
Topics: Animals; Cell Line; Cell Proliferation; CHO Cells; Chromatography, Gel; Cloning, Molecular; Computer Simulation; Cricetinae; Cricetulus; Cysteine; Drug Delivery Systems; Erythropoietin; Glutamic Acid; Humans; Methotrexate; Molecular Dynamics Simulation; Mutagenesis, Site-Directed; Nanoparticles; Polyethylene Glycols; Protein Binding; Protein Stability; Recombinant Proteins; Spectroscopy, Fourier Transform Infrared | 2011 |
Single-center, retrospective analysis of efficacy and safety of tacrolimus as a second-line DMARD in combination therapy and the risk factors contributing to adverse events in 115 patients with rheumatoid arthritis.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Cysteine; Disease Progression; Drug Therapy, Combination; Female; Humans; Male; Methotrexate; Middle Aged; Retrospective Studies; Risk Factors; Severity of Illness Index; Sulfasalazine; Tacrolimus; Treatment Outcome | 2012 |
Recent trends in use of nonbiologic DMARDs and evaluation of their continuation rates in single and dual combination therapies in rheumatoid arthritis patients in Japan.
Topics: Adult; Antirheumatic Agents; Arthritis, Rheumatoid; Cysteine; Drug Therapy, Combination; Female; Humans; Japan; Male; Methotrexate; Practice Patterns, Physicians'; Severity of Illness Index; Sulfasalazine; Treatment Outcome | 2012 |
Bucillamine inhibits CD40-mediated Akt activation and antibody production in mouse B-cell lymphoma.
Topics: Animals; Antibody Formation; CD40 Antigens; Cell Line, Tumor; Cell Proliferation; Cysteine; Enzyme Activation; Methotrexate; Mice; Oncogene Protein v-akt; Phosphorylation | 2012 |
[Anti-rheumatic drugs].
Topics: Antirheumatic Agents; Cysteine; Hematologic Diseases; Humans; Hypersensitivity; Infections; Isoxazoles; Kidney Diseases; Leflunomide; Liver Neoplasms; Lung Diseases; Methotrexate | 2012 |
[Rheumatoid arthritis: progress in diagnosis and treatment. Topics: IV. Treatment; 2. Antirheumatic agents, 1) non-biologic agents].
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Cysteine; Female; Humans; Methotrexate; Sulfasalazine; Tacrolimus | 2012 |
Substituted cysteine accessibility reveals a novel transmembrane 2-3 reentrant loop and functional role for transmembrane domain 2 in the human proton-coupled folate transporter.
Topics: Amino Acid Sequence; Amino Acid Substitution; Binding Sites; Biological Transport; Biotinylation; Blotting, Western; Cell Membrane; Cysteine; Folic Acid; Folic Acid Antagonists; Glutamates; Guanine; HeLa Cells; Humans; Kinetics; Methotrexate; Molecular Sequence Data; Mutation; Pemetrexed; Protein Structure, Secondary; Proton-Coupled Folate Transporter; Tritium | 2014 |
The usefulness of a new triple combination treatment utilizing methotrexate, salazosulfapyridine, and bucillamine in rheumatoid arthritis.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Biological Products; Cysteine; Drug Therapy, Combination; Female; Humans; Japan; Male; Methotrexate; Middle Aged; Sulfasalazine; Treatment Outcome | 2016 |
Methotrexate-conjugated quantum dots: synthesis, characterisation and cytotoxicity in drug resistant cancer cells.
Topics: Antineoplastic Agents; Cell Line, Tumor; Cysteine; Drug Delivery Systems; Drug Resistance, Neoplasm; Endocytosis; Folic Acid; Humans; KB Cells; Methotrexate; Nanoconjugates; Quantum Dots | 2016 |
Methotrexate administration induces differential and selective protein tyrosine nitration and cysteine nitrosylation in the subcellular organelles of the small intestinal mucosa of rats.
Topics: Animals; Blotting, Western; Cysteine; Cytosol; Intestinal Mucosa; Intestine, Small; Male; Methotrexate; Mitochondrial Proteins; Nuclear Proteins; Proteins; Rats; Rats, Wistar; Tyrosine | 2016 |
Conjugation of Methotrexate-Amino Derivatives to Macromolecules through Carboxylate Moieties Is Superior Over Conventional Linkage to Amino Residues: Chemical, Cell-Free and In Vitro Characterizations.
Topics: Animals; Antineoplastic Agents; Carboxylic Acids; Cattle; Cell Line, Tumor; Cysteine; Glioma; Humans; Hydrogen-Ion Concentration; Hydrolysis; Methotrexate; Peptides; Polyethylene Glycols; Serum Albumin, Bovine | 2016 |
Cysteine capped copper/molybdenum bimetallic nanoclusters for fluorometric determination of methotrexate via the inner filter effect.
Topics: Copper; Cysteine; Fluorescent Dyes; Humans; Hydrogen-Ion Concentration; Limit of Detection; Metal Nanoparticles; Methotrexate; Molybdenum; Particle Size; Spectrometry, Fluorescence; Surface Properties | 2019 |
A Previously Unknown Drug-Drug Interaction Is Suspected in Delayed Elimination of Plasma Methotrexate in High-Dose Methotrexate Therapy.
Topics: Cysteine; Drug Combinations; Drug Interactions; Drug Monitoring; Female; Glycine; Glycyrrhetinic Acid; Humans; Leukemia; Logistic Models; Lymphoma; Male; Metabolic Clearance Rate; Methotrexate; Osteosarcoma; Retrospective Studies; Risk Factors; Vincristine | 2020 |
A proton-coupled folate transporter mutation causing hereditary folate malabsorption locks the protein in an inward-open conformation.
Topics: Amino Acid Sequence; Animals; Biological Transport; Cysteine; Folic Acid Deficiency; HeLa Cells; Humans; Kinetics; Malabsorption Syndromes; Methotrexate; Mutagenesis, Site-Directed; Protein Structure, Tertiary; Proton-Coupled Folate Transporter | 2020 |
A simple and accurate HFCF-UF method for the analysis of homocysteine, cysteine, cysteinyl-glycine, and glutathione in human blood.
Topics: Anti-Bacterial Agents; Blood Chemical Analysis; Chromatography, High Pressure Liquid; Cysteine; Dipeptides; Enzyme Inhibitors; Freezing; Glutathione; Homocysteine; Humans; Limit of Detection; Methotrexate; Molecular Structure; Tandem Mass Spectrometry; Temperature; Ultrafiltration; Valproic Acid; Vancomycin | 2021 |