Compounds > cysteine

cysteine and fosfomycin

cysteine has been researched along with fosfomycin in 18 studies

Research

Studies (18)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's3 (16.67)18.2507
2000's4 (22.22)29.6817
2010's9 (50.00)24.3611
2020's2 (11.11)2.80

Authors

AuthorsStudies
Brown, ED; Haley, TM; Ichikawa, Y; Lane, WS; Marquardt, JL; Walsh, CT; Wong, CH1
Amrhein, N; Wanke, C1
Duncan, K; Kempsell, KE; Kim, DH; Lane, WS; Lees, WJ; Walsh, CT1
Amrhein, N; Eschenburg, S; Krekel, F; Luger, K; Schönbrunn, E1
Armstrong, RN; Bernat, BA; Cao, M; Helmann, JD; Wang, Z1
Amrhein, N; Etezady-Esfarjani, T; Macheroux, P; Samland, AK1
Berti, PJ; Chindemi, P; Jackson, SG; Junop, MS; Zhang, F1
Antelmann, H; Claiborne, A; Fahey, RC; Gaballa, A; Helmann, JD; Newton, GL; Parsonage, D; Rawat, M; Upton, H1
Hamilton, CJ; Jothivasan, VK; Kane, MG; La Clair, JJ; Newton, GL; Rawat, M; Roberts, AA; Sharma, SV; Upton, H; Wakabayashi, JI1
Armstrong, RN; Cook, PD; Hines, KM; Keithly, ME; Kim, K; Lamers, AP; Stec, DF; Sulikowski, GA1
Duran, SR; Hamilton, CJ; Rawat, M; Roberts, AA; Sharma, SV; Strankman, AW1
Aharonowitz, Y; Antelmann, H; Borovok, I; Gierok, P; Hamilton, CJ; Harms, M; Hecker, M; Hochgräfe, F; Lalk, M; Mostertz, J; Pöther, DC1
Kitade, Y; Kusakabe, Y; Nakamura, KT; Nakanishi, M; Tanaka, N; Umeda, T1
Armstrong, RN; Cook, PD; Harp, J; Jagessar, KL; Keithly, ME; Sulikowski, GA; Thompson, MK1
Armstrong, RN; Cook, PD; Goodman, MC; Hammer, ND; Harp, J; Jagessar, KL; Keithly, ME; Skaar, EP; Thompson, MK1
Kesler, MBA; Lewis, AD; Long, TE; Riedel, TM; Varney, ME1
Ábrányi-Balogh, P; Dolšak, A; Gobec, S; Grabrijan, K; Hrast, M; Imre, T; Keserű, GM; Petri, L; Proj, M; Zdovc, I1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K1

Reviews

2 review(s) available for cysteine and fosfomycin

ArticleYear
[Structural biology for developing antimalarial compounds].
    Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan, 2013, Volume: 133, Issue:5

    Topics: Adenosylhomocysteinase; Aldose-Ketose Isomerases; Animals; Antimalarials; Catalytic Domain; Clinical Trials as Topic; Crystallization; Crystallography; Cysteine; Drug Design; Enzyme Inhibitors; Fosfomycin; Humans; Molecular Conformation; Plasmodium falciparum; Protein Structure, Tertiary; Structure-Activity Relationship; Threonine

2013
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
    Drug discovery today, 2016, Volume: 21, Issue:4

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk

2016

Other Studies

16 other study(ies) available for cysteine and fosfomycin

ArticleYear
Kinetics, stoichiometry, and identification of the reactive thiolate in the inactivation of UDP-GlcNAc enolpyruvoyl transferase by the antibiotic fosfomycin.
    Biochemistry, 1994, Sep-06, Volume: 33, Issue:35

    Topics: Alkyl and Aryl Transferases; Bacterial Proteins; Binding Sites; Cysteine; Escherichia coli; Fosfomycin; Kinetics; Mass Spectrometry; Peptide Mapping; Transferases; Uridine Diphosphate N-Acetylglucosamine

1994
Evidence that the reaction of the UDP-N-acetylglucosamine 1-carboxyvinyltransferase proceeds through the O-phosphothioketal of pyruvic acid bound to Cys115 of the enzyme.
    European journal of biochemistry, 1993, Dec-15, Volume: 218, Issue:3

    Topics: Alkyl and Aryl Transferases; Amino Acid Sequence; Base Sequence; Binding Sites; Chromatography, High Pressure Liquid; Cysteine; Enterobacter; Escherichia coli; Fosfomycin; Molecular Sequence Data; Mutagenesis, Site-Directed; Phosphates; Phosphoenolpyruvate; Pyruvates; Pyruvic Acid; Transferases

1993
Characterization of a Cys115 to Asp substitution in the Escherichia coli cell wall biosynthetic enzyme UDP-GlcNAc enolpyruvyl transferase (MurA) that confers resistance to inactivation by the antibiotic fosfomycin.
    Biochemistry, 1996, Apr-16, Volume: 35, Issue:15

    Topics: Alkyl and Aryl Transferases; Anti-Bacterial Agents; Aspartic Acid; Catalysis; Cell Wall; Cysteine; Drug Resistance, Microbial; Escherichia coli; Fosfomycin; Kinetics; Mutagenesis, Site-Directed; Thermodynamics; Transferases

1996
Role of the loop containing residue 115 in the induced-fit mechanism of the bacterial cell wall biosynthetic enzyme MurA.
    Biochemistry, 2000, Mar-07, Volume: 39, Issue:9

    Topics: Alkyl and Aryl Transferases; Amino Acid Substitution; Catalysis; Cell Wall; Conserved Sequence; Crystallography, X-Ray; Cysteine; Enterobacter cloacae; Enzyme Activation; Enzyme Inhibitors; Fosfomycin; Ligands; Mutagenesis, Site-Directed; Peptide Fragments; Serine; Spectrometry, Fluorescence; Thermodynamics

2000
FosB, a cysteine-dependent fosfomycin resistance protein under the control of sigma(W), an extracytoplasmic-function sigma factor in Bacillus subtilis.
    Journal of bacteriology, 2001, Volume: 183, Issue:7

    Topics: Amino Acid Sequence; Bacillus subtilis; Bacterial Proteins; Cysteine; Drug Resistance, Microbial; Escherichia coli; Fosfomycin; Glutathione Transferase; Magnesium; Manganese; Molecular Sequence Data; Sigma Factor; Transcription, Genetic

2001
Asparagine 23 and aspartate 305 are essential residues in the active site of UDP-N-acetylglucosamine enolpyruvyl transferase from Enterobacter cloacae.
    Biochemistry, 2001, Feb-13, Volume: 40, Issue:6

    Topics: Alkyl and Aryl Transferases; Amino Acid Substitution; Asparagine; Aspartic Acid; Binding Sites; Catalysis; Cysteine; Enterobacter cloacae; Enzyme Inhibitors; Fosfomycin; Mutagenesis, Site-Directed; Phosphates; Phosphoenolpyruvate; Recombinant Proteins; Uridine Diphosphate N-Acetylglucosamine

2001
Evidence of kinetic control of ligand binding and staged product release in MurA (enolpyruvyl UDP-GlcNAc synthase)-catalyzed reactions .
    Biochemistry, 2009, Dec-15, Volume: 48, Issue:49

    Topics: Alkyl and Aryl Transferases; Catalysis; Catalytic Domain; Crystallography, X-Ray; Cysteine; Escherichia coli Proteins; Fosfomycin; Kinetics; Ligands; Phosphoenolpyruvate; Protein Binding; Protein Conformation

2009
Biosynthesis and functions of bacillithiol, a major low-molecular-weight thiol in Bacilli.
    Proceedings of the National Academy of Sciences of the United States of America, 2010, Apr-06, Volume: 107, Issue:14

    Topics: Bacillus subtilis; Cysteine; Disulfides; Drug Resistance, Bacterial; Fosfomycin; Genome, Bacterial; Glucosamine; Glycosyltransferases; Molecular Structure; Molecular Weight; Multigene Family; Mutation; Oxidative Stress; Phylogeny; Stress, Physiological

2010
Chemical and Chemoenzymatic syntheses of bacillithiol: a unique low-molecular-weight thiol amongst low G + C Gram-positive bacteria.
    Angewandte Chemie (International ed. in English), 2011, Jul-25, Volume: 50, Issue:31

    Topics: Anti-Bacterial Agents; Biocatalysis; Cysteine; Fosfomycin; Glucosamine; Gram-Positive Bacteria; Sulfhydryl Compounds; Transferases

2011
Synthesis of bacillithiol and the catalytic selectivity of FosB-type fosfomycin resistance proteins.
    Organic letters, 2012, Oct-19, Volume: 14, Issue:20

    Topics: Bacillus; Biocatalysis; Cysteine; Fosfomycin; Glucosamine; Molecular Structure; Proto-Oncogene Proteins c-fos; Staphylococcus aureus; Substrate Specificity

2012
Mechanistic studies of FosB: a divalent-metal-dependent bacillithiol-S-transferase that mediates fosfomycin resistance in Staphylococcus aureus.
    The Biochemical journal, 2013, Apr-01, Volume: 451, Issue:1

    Topics: Anti-Bacterial Agents; Bacterial Proteins; Cysteine; Drug Resistance, Bacterial; Fosfomycin; Glucosamine; Kinetics; Magnesium; Manganese; Staphylococcus aureus; Transferases

2013
Distribution and infection-related functions of bacillithiol in Staphylococcus aureus.
    International journal of medical microbiology : IJMM, 2013, Volume: 303, Issue:3

    Topics: Animals; Anti-Bacterial Agents; Antioxidants; Bacterial Load; Cell Line; Chromatography, High Pressure Liquid; Cysteine; Diamide; Drug Resistance, Bacterial; Epithelial Cells; Fosfomycin; Gene Expression; Glucosamine; Humans; Hydrogen Peroxide; Hypochlorous Acid; Macrophages; Mice; Oxidants; Staphylococcus aureus; Virulence Factors

2013
Structural and chemical aspects of resistance to the antibiotic fosfomycin conferred by FosB from Bacillus cereus.
    Biochemistry, 2013, Oct-15, Volume: 52, Issue:41

    Topics: Anti-Bacterial Agents; Bacillus cereus; Bacterial Proteins; Crystallography, X-Ray; Cysteine; Fosfomycin; Glucosamine; Kinetics; Substrate Specificity; Transferases

2013
Structure and function of the genomically encoded fosfomycin resistance enzyme, FosB, from Staphylococcus aureus.
    Biochemistry, 2014, Feb-04, Volume: 53, Issue:4

    Topics: Amino Acid Sequence; Anti-Bacterial Agents; Bacterial Proteins; Catalytic Domain; Cations, Divalent; Crystallography, X-Ray; Cysteine; Drug Resistance, Bacterial; Fosfomycin; Genome, Bacterial; Glucosamine; Kinetics; Models, Molecular; Molecular Sequence Data; Protein Conformation; Staphylococcus aureus; Sulfates; Transferases; Zinc

2014
Pharmacological evaluation of disulfiram analogs as antimicrobial agents and their application as inhibitors of fosB-mediated fosfomycin resistance.
    The Journal of antibiotics, 2022, Volume: 75, Issue:3

    Topics: Anti-Infective Agents; Bacterial Proteins; Cysteine; Disulfiram; Drug Resistance, Bacterial; Fosfomycin; Glucosamine; Humans; Methicillin-Resistant Staphylococcus aureus; Microbial Sensitivity Tests; Proto-Oncogene Proteins c-fos; Staphylococcal Infections; Sulfhydryl Compounds

2022
Covalent inhibitors of bacterial peptidoglycan biosynthesis enzyme MurA with chloroacetamide warhead.
    European journal of medicinal chemistry, 2022, Dec-05, Volume: 243

    Topics: Alkyl and Aryl Transferases; Anti-Bacterial Agents; Chromatography, Liquid; Cysteine; Enzyme Inhibitors; Escherichia coli; Fosfomycin; Peptidoglycan; Tandem Mass Spectrometry

2022