cysteine has been researched along with epidermal growth factor in 92 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (5.43) | 18.7374 |
| 1990's | 33 (35.87) | 18.2507 |
| 2000's | 32 (34.78) | 29.6817 |
| 2010's | 14 (15.22) | 24.3611 |
| 2020's | 8 (8.70) | 2.80 |
| Authors | Studies |
|---|---|
| Cutting, GR; Dietz, HC; Francomano, CA; Pyeritz, RE; Saraiva, JM | 1 |
| Lukas, TJ; Staros, JV; Woltjer, RL | 1 |
| Enger, MD; Kang, YJ | 1 |
| Walker, P | 1 |
| Bellot, F; Burgess, WH; Givol, D; Lax, I; Schlessinger, J; Ullrich, A | 1 |
| Kato, S; Kohno, K; Martin, GR; Sasaki, M; Yamada, Y | 1 |
| Andrews, ME; Hursh, DA; Raff, RA | 1 |
| Gillespie, JM; Marshall, RC; Moore, GP; Panaretto, BA; Robertson, DM | 1 |
| Milewicz, DM; Putnam, EA; Ramirez, F; Zhang, H | 1 |
| Couchman, JR; Hassell, JR; Horchar, T; Ljubimov, AV; Sthanam, M | 1 |
| Chen, Q; Goetinck, PF; Haudenschild, DR; Hofer, U; Tondravi, MM | 1 |
| Mayer, WE; Tichy, H | 1 |
| Keene, DR; Sakai, LY | 1 |
| Munekata, E; Ohtaki, T; Shimizu, M; Shin, SY | 1 |
| Kays, SE; Schnellmann, RG | 1 |
| Chung, AE; Dong, LJ; Hsieh, JC | 1 |
| Cadle, RG; Dietz, HC; Francomano, CA; Hall, BD; McIntosh, I; Piersall, LD; Pyeritz, RE | 1 |
| Liu, CF; Tam, JP | 1 |
| Blake, DA; Grant, MB; McLean, NV; Munjal, ID | 1 |
| Kainulainen, K; Kristofersson, U; Peltonen, L; Saxne, T; Ståhl-Hallengren, C; Tornqvist, K; Ukkonen, T | 1 |
| Rao, C; Spetzler, JC; Tam, JP | 1 |
| Bonadio, J; D'Alessio, M; Lynch, JR; Pangilinan, T; Pereira, L; Ramirez, F; Sykes, B | 1 |
| Alcamo, E; Corbin, V; Kidd, S; Lieber, T; Young, MW | 1 |
| Baker, E; Davis, EC; Gibson, MA; Hatzinikolas, G; Mecham, RP; Sutherland, GR | 1 |
| Keski-Oja, J; Saharinen, J; Taipale, J | 1 |
| Morrison, P; Rosner, MR; Saltiel, AR | 1 |
| Arcila, P; Bennett, WF; Berleau, LT; Keyt, BA; Nguyen, HV; Sehl, LC | 1 |
| Guyer, CA; Staros, JV; Tong, K | 1 |
| Arlaud, GJ; Bersch, B; Gagnon, J; Hernandez, JF; Pétillot, Y | 1 |
| Kim, SR; Kwon, KS; Lee, SR; Rhee, SG | 1 |
| Bhatnagar, A; Chandra, A; Harter, TM; Petrash, JM; Srivastava, S; Srivastava, SK | 2 |
| Kwon, KS; Rhee, SG; Wu, Y | 1 |
| Keasler, KB; McKeller, DE; Nowak, G; Schnellmann, RG | 1 |
| Alewood, D; Alewood, PF; Barnham, KJ; Domagala, T; Nice, EC; Norton, RS; Torres, AM | 1 |
| Kroeger, M; Sang, QX; Stone, AL | 1 |
| Brenn, T; Francke, U; Furthmayr, H; Liu, W; Schrijver, I | 1 |
| Ebisu, S; Fujii, T; Miyauchi, A; Mizukami, M; Ozawa, M; Takagi, H; Tojo, T; Yashiro, K | 1 |
| Bennett, BD; Dodson, WS; Haniu, M; Harding, BJ; Jarosinski, MA; Jones, T; Lenz, DM; Liu, CF; Young, Y; Zamborelli, TJ; Zhang, J | 1 |
| Guy, GR; Lim, J; Low, BC; Ong, SH; Wong, ES; Yusoff, P | 1 |
| Fryxell, KJ; Jordan, TV; Soderlund, M | 1 |
| Alessi, DR; Arthur, JS; Deak, M; Kieloch, A; Lain, S; Lizcano, JM; Morrice, N; Sapkota, GP; Williams, MR | 1 |
| Cunnick, JM; Doupnik, CA; Mei, L; Wu, J | 1 |
| Ameen, AS; Campion, SR; King, JM; Lai, L; Munzenmaier, TN | 1 |
| Beglova, N; Blacklow, SC; Springer, TA; Takagi, J; Yalamanchili, P | 1 |
| Lago, CT; Manco, G; Minchiotti, G; Parisi, S; Persico, MG; Rosa, F | 1 |
| Bozsó, Z; Gembitsky, DS; Lovas, S; Murphy, RF; O'Flaharty, M; Otvös, F | 1 |
| Denu, JM; Tanner, KG | 1 |
| Bar-Sagi, D; Egan, JE; Hall, AB; Yatsula, BA | 1 |
| Liu, DX; Ng, LF | 1 |
| Cuthbertson, A; Husbyn, M | 1 |
| Gu, LH; Jonas, CR; Jones, DP; Ziegler, TR | 1 |
| Andersen, JN; Barford, D; Hinks, JA; Meng, TC; Myers, MP; Salmeen, A; Tonks, NK | 1 |
| Kobbe, B; Morgelin, M; Paulsson, M; Sengle, G; Wagener, R | 1 |
| Ambo, H; Handa, M; Ikeda, Y; Kamata, T; Puzon-McLaughlin, W; Takada, Y; Tieu, KK | 1 |
| Bätge, B; Brinckmann, J; El-Hallous, E; John, H; Lin, G; Notbohm, H; Reinhardt, DP; Tiedemann, K; Vollbrandt, T | 1 |
| Handford, PA; Jensen, S; McGettrick, A; Redfield, C; Suk, JY; Whiteman, P; Willis, AC | 1 |
| Guarnaccia, C; Pintar, A; Pongor, S; Zanuttin, F | 1 |
| Fukui, Y; Kishida, R; Lee, ES | 1 |
| Cohen, MS; Shokat, KM; Taunton, J; Zhang, C | 1 |
| Alewood, D; Alewood, PF; Andrews, P; Burgess, AW; Craik, DJ; Domagala, T; Nerrie, M; Nice, EC; Nielsen, K; Rothacker, J; Walker, F; White, S | 1 |
| Becker, CG; Becker, T; Granato, M; Lefebvre, J; Schachner, M; Schweitzer, J | 1 |
| Cantin, GT; Carucci, DJ; Crabb, BS; Gilson, PR; Greenbaum, DC; Hodder, AN; McConville, MJ; Nebl, T; Sanders, PR; Schofield, L; Yates, JR | 1 |
| Cheng-Hsien, C; Chun-Cheng, H; Horng-Mo, L; Huei-Mei, H; Tso-Hsiao, C; Yuh-Mou, S; Yung-Ho, H | 1 |
| Chang, JY; Jiang, C; Lu, BY | 1 |
| Alvarado, D; Buglino, J; Lemmon, MA; Miura, GI; Resh, MD; Treisman, JE | 1 |
| Corredor, J; Dvorak, LA; Frey, MR; Ho, SB; Jacobson, AC; Moor, RE; Polk, DB; Shekels, LL | 1 |
| Asakuma, S; Fukui, Y; Kobayashi, M | 1 |
| Castro, C; Estrada, C; Murillo-Carretero, M; Torroglosa, A; Villalobo, A | 1 |
| Annis, DS; Liu, Y; Mosher, DF | 1 |
| Haehn, S; Ihling, CH; Kalkhof, S; Keller, MV; Müller, MQ; Paulsson, M; Sinz, A; Smyth, N; Witte, K | 1 |
| Bird, SD; Legge, M; Walker, RJ | 1 |
| Appelbaum, JS; Lowder, MA; Scheck, RA; Schepartz, A | 1 |
| Carroll, KS; Truong, TH | 1 |
| Takata, T; Tsuchiya, Y; Watanabe, Y | 1 |
| Cosenza, MR; Ellenberg, J; Fry, AM; Isokane, M; Krämer, A; Mardin, BR; Schiebel, E | 1 |
| Brunsveld, L; Ibach, J; Nieto, L; Sonntag, MH; Verveer, PJ | 1 |
| Carroll, KS; Gupta, V; Liebler, DC; Yang, J | 1 |
| Blessing, AM; Bollu, LR; Gao, G; Katreddy, RR; Ren, J; Su, F; Wang, J; Weihua, Z; Xu, L | 1 |
| Cao, XJ; Garcia, BA; Kharbanda, A; Runkle, KB; Stypulkowski, E; Wang, W; Witze, ES | 1 |
| Haar Petersen, M; Huang, H; Ibañez-Vea, M; Larsen, MR; Lassen, PS; Palmisano, G | 1 |
| Lisse, TS; Rieger, S | 1 |
| Hu, P; Luo, BH | 1 |
| Fujimura, K; Hirata, Y; Norisada, J; Oh-Hashi, K | 1 |
| Abiko, Y; Akaike, T; Arnér, ESJ; Balog, N; Cheng, Q; Dagnell, M; Dóka, É; Espinosa, B; Fukuto, JM; Funato, Y; Ida, T; Kumagai, Y; Luong, NC; Miki, H; Nagy, P; Nishimura, A; Prigge, JR; Schmidt, EE; Takata, T | 1 |
| Behring, JB; Bowman, GR; Clements, JL; Egan, MJ; Held, JM; Mooradian, AD; van der Post, S; Zimmerman, MI | 1 |
| Cartee, NMP; Lee, SJ; Wang, MM; Young, KZ; Zhang, X | 1 |
| Hwang, I; Kang, H; Khan, MRI; Thangarasu, M | 1 |
| Hojo, H; Moroder, L; Okumura, N; Takao, T; Takei, T; Tanaka, H | 1 |
| Okamoto, K; Sako, Y | 1 |
| Lee, SJ; Sukpraphrute, C; Sukpraphrute, R; Wang, MM; Wu, E; Ye, A; Zhang, X | 1 |
| Lin, H; Lu, D; Qiao, X; Zhang, Y | 1 |
1 review(s) available for cysteine and epidermal growth factor
| Article | Year |
|---|---|
Redox regulation of epidermal growth factor receptor signaling through cysteine oxidation.
Topics: Cysteine; Epidermal Growth Factor; ErbB Receptors; Humans; Hydrogen Peroxide; Membrane Glycoproteins; NADPH Oxidase 2; NADPH Oxidases; Oxidation-Reduction; Phosphorylation; Second Messenger Systems; Signal Transduction; Sulfenic Acids | 2012 |
1 trial(s) available for cysteine and epidermal growth factor
| Article | Year |
|---|---|
Substitution of a cysteine residue in a non-calcium binding, EGF-like domain of fibrillin segregates with the Marfan syndrome in a large kindred.
Topics: Amino Acid Sequence; Base Sequence; Chromosome Mapping; Chromosomes, Human, Pair 15; Cysteine; DNA Primers; Epidermal Growth Factor; Fibrillins; Genetic Variation; Humans; Marfan Syndrome; Microfilament Proteins; Molecular Sequence Data; Polymerase Chain Reaction | 1994 |
90 other study(ies) available for cysteine and epidermal growth factor
| Article | Year |
|---|---|
Clustering of fibrillin (FBN1) missense mutations in Marfan syndrome patients at cysteine residues in EGF-like domains.
Topics: Amino Acid Sequence; Base Sequence; Cysteine; DNA; DNA Mutational Analysis; Epidermal Growth Factor; Fibrillin-1; Fibrillins; Humans; Marfan Syndrome; Microfilament Proteins; Molecular Sequence Data; Molecular Structure; Phenotype; Polymerase Chain Reaction; Polymorphism, Genetic; Repetitive Sequences, Nucleic Acid | 1992 |
Direct identification of residues of the epidermal growth factor receptor in close proximity to the amino terminus of bound epidermal growth factor.
Topics: Amino Acid Sequence; Animals; Binding Sites; Cell Line; Chromatography, Affinity; Cross-Linking Reagents; Cysteine; Epidermal Growth Factor; ErbB Receptors; Humans; Iodine Radioisotopes; Mice; Molecular Sequence Data; Phosphotyrosine; Protein Conformation; Tyrosine | 1992 |
Increased glutathione levels in quiescent, serum-stimulated NRK-49F cells are associated not with a response to growth factors but with nutrient repletion.
Topics: Animals; Blood; Buthionine Sulfoximine; Cell Division; Cell Line; Culture Media; Cysteine; DNA; Epidermal Growth Factor; Glutamates; Glutamic Acid; Glutathione; Growth Substances; Interphase; Methionine Sulfoximine | 1991 |
Thyroxine increases neonatal mouse submandibular gland mRNA-directed synthesis of epidermal growth factor.
Topics: Animals; Cysteine; Epidermal Growth Factor; Female; Male; Mice; Poly A; Pregnancy; Protein Biosynthesis; RNA; RNA, Messenger; Submandibular Gland; Sulfur Radioisotopes; Thyroxine | 1986 |
Localization of a major receptor-binding domain for epidermal growth factor by affinity labeling.
Topics: Affinity Labels; Antibodies; Cell Line; Cross-Linking Reagents; Cyanogen Bromide; Cysteine; Epidermal Growth Factor; ErbB Receptors; Humans; Iodine Radioisotopes; Methionine; Peptide Fragments; Succinimides; Sulfur Radioisotopes | 1988 |
Sequence of the cDNA encoding the laminin B1 chain reveals a multidomain protein containing cysteine-rich repeats.
Topics: Amino Acid Sequence; Animals; Base Sequence; Cloning, Molecular; Cysteine; DNA, Circular; Epidermal Growth Factor; Genetic Code; Laminin; Mice; Proteins | 1987 |
A sea urchin gene encodes a polypeptide homologous to epidermal growth factor.
Topics: Animals; Cysteine; DNA; Epidermal Growth Factor; Gene Expression Regulation; Humans; Mice; Nucleic Acid Hybridization; Peptides; Repetitive Sequences, Nucleic Acid; RNA, Messenger; Sea Urchins | 1987 |
Changes in the proteins of wool following treatment of sheep with epidermal growth factor.
Topics: Animals; Cysteine; Dose-Response Relationship, Drug; Electrophoresis, Polyacrylamide Gel; Epidermal Growth Factor; Hair; Infusions, Parenteral; Male; Mice; Protein Biosynthesis; Proteins; Sheep; Sulfur; Time Factors; Tyrosine | 1982 |
Fibrillin-2 (FBN2) mutations result in the Marfan-like disorder, congenital contractural arachnodactyly.
Topics: Base Sequence; Cell Line; Cysteine; DNA Mutational Analysis; Epidermal Growth Factor; Fibrillin-1; Fibrillin-2; Fibrillins; Fibroblasts; Humans; Marfan Syndrome; Microfilament Proteins; Molecular Sequence Data; Point Mutation; Polymorphism, Single-Stranded Conformational; Protein Structure, Tertiary; Repetitive Sequences, Nucleic Acid | 1995 |
Antibody mapping and tissue localization of globular and cysteine-rich regions of perlecan domain III.
Topics: Animals; Antibodies, Monoclonal; Base Sequence; Codon; Cornea; Cysteine; DNA Primers; Enzyme-Linked Immunosorbent Assay; Epidermal Growth Factor; Epitopes; Fluorescent Antibody Technique; Heparan Sulfate Proteoglycans; Heparitin Sulfate; Kidney; Liver; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Microscopy, Fluorescence; Molecular Sequence Data; Muscle, Skeletal; Polymerase Chain Reaction; Proteoglycans; Recombinant Proteins; Restriction Mapping; Skin; Spleen | 1995 |
The role of coiled-coil alpha-helices and disulfide bonds in the assembly and stabilization of cartilage matrix protein subunits. A mutational analysis.
Topics: Amino Acid Sequence; Animals; Base Sequence; Cartilage; Cell Line; Chickens; Chlorocebus aethiops; Cysteine; Disulfides; DNA Mutational Analysis; DNA Primers; Drug Stability; Epidermal Growth Factor; Extracellular Matrix Proteins; Glycoproteins; Macromolecular Substances; Matrilin Proteins; Molecular Sequence Data; Mutagenesis, Site-Directed; Polymerase Chain Reaction; Protein Structure, Secondary; Recombinant Proteins; Transfection | 1995 |
A cDNA clone from the sea lamprey Petromyzon marinus coding for a scavenger receptor Cys-rich (SRCR) domain protein.
Topics: Amino Acid Sequence; Animals; Antigens, CD; Antigens, Differentiation, T-Lymphocyte; Base Sequence; Cell Membrane; Cloning, Molecular; Consensus Sequence; Cysteine; DNA, Complementary; Epidermal Growth Factor; Gene Library; Humans; Lampreys; Macrophages; Mammals; Membrane Glycoproteins; Membrane Proteins; Molecular Sequence Data; Phylogeny; Protein Biosynthesis; Receptors, Immunologic; Receptors, Lipoprotein; Receptors, Scavenger; Recombinant Proteins; Scavenger Receptors, Class B; Sequence Homology, Amino Acid; T-Lymphocytes | 1995 |
Fibrillin: monomers and microfibrils.
Topics: Alternative Splicing; Amino Acid Sequence; Cells, Cultured; Chromatography, Affinity; Cysteine; Disulfides; Epidermal Growth Factor; Extracellular Matrix Proteins; Fibrillins; Fluorescent Antibody Technique; Humans; Marfan Syndrome; Microfilament Proteins; Microscopy, Electron; Molecular Sequence Data; Mutation; Protein Conformation | 1994 |
Synthesis and biological activity of N-terminal-truncated derivatives of human epidermal growth factor (h-EGF).
Topics: 3T3 Cells; Amino Acid Sequence; Animals; Binding, Competitive; Carcinoma, Squamous Cell; Cell Division; Chromatography, High Pressure Liquid; Cysteine; Dose-Response Relationship, Drug; Epidermal Growth Factor; ErbB Receptors; Humans; Indicators and Reagents; Kinetics; Mice; Molecular Sequence Data; Peptide Fragments; Protein Conformation; Protein Folding; Tumor Cells, Cultured | 1995 |
Regeneration of renal proximal tubule cells in primary culture following toxicant injury: response to growth factors.
Topics: Animals; Cells, Cultured; Cysteine; Epidermal Growth Factor; Female; Growth Substances; Insulin; Insulin-Like Growth Factor I; Kidney Tubules, Proximal; Oligopeptides; Peroxides; Rabbits; Reactive Oxygen Species; Regeneration; tert-Butylhydroperoxide | 1995 |
Two distinct cell attachment sites in entactin are revealed by amino acid substitutions and deletion of the RGD sequence in the cysteine-rich epidermal growth factor repeat 2.
Topics: Amino Acid Sequence; Base Sequence; Binding Sites; Cell Adhesion; Cysteine; Epidermal Growth Factor; Humans; Integrins; Membrane Glycoproteins; Molecular Sequence Data; Oligopeptides | 1995 |
Peptide segment ligation strategy without use of protecting groups.
Topics: Amino Acid Sequence; Cysteine; Disulfides; Epidermal Growth Factor; Esters; Indicators and Reagents; Mass Spectrometry; Molecular Sequence Data; Molecular Weight; Peptides; Proteins; Threonine | 1994 |
Differences in the synthesis of secreted proteins in human retinal endothelial cells of diabetic and nondiabetic origin.
Topics: Adult; Cells, Cultured; Cysteine; Diabetic Retinopathy; Electrophoresis, Polyacrylamide Gel; Endothelium, Vascular; Epidermal Growth Factor; Eye Proteins; Female; Fibroblast Growth Factors; Humans; Immunoblotting; Male; Methionine; Middle Aged; Molecular Weight; Retina | 1994 |
An extra cysteine in one of the non-calcium-binding epidermal growth factor-like motifs of the FBN1 polypeptide is connected to a novel variant of Marfan syndrome.
Topics: Adult; Base Sequence; Calcium; Chromosomes, Human, Pair 15; Cysteine; Epidermal Growth Factor; Fibrillin-1; Fibrillins; Genetic Linkage; Humans; Male; Marfan Syndrome; Microfilament Proteins; Molecular Sequence Data; Mutation; Pedigree | 1994 |
A novel strategy for the synthesis of the cysteine-rich protective antigen of the malaria merozoite surface protein (MSP-1). Knowledge-based strategy for disulfide formation.
Topics: Amino Acid Sequence; Animals; Chromatography, High Pressure Liquid; Cysteine; Dimethyl Sulfoxide; Disulfides; Epidermal Growth Factor; Malaria Vaccines; Merozoite Surface Protein 1; Molecular Sequence Data; Peptide Fragments; Plasmodium falciparum; Protein Folding; Protein Precursors; Protozoan Proteins; Thermolysin | 1994 |
Genomic organization of the sequence coding for fibrillin, the defective gene product in Marfan syndrome.
Topics: Amino Acid Sequence; Base Sequence; Carrier Proteins; Chromosome Mapping; Chromosomes, Fungal; Cloning, Molecular; Cysteine; DNA; Epidermal Growth Factor; Exons; Fibrillins; Gene Library; Genome, Human; Humans; Intracellular Signaling Peptides and Proteins; Latent TGF-beta Binding Proteins; Marfan Syndrome; Microfilament Proteins; Molecular Sequence Data; Repetitive Sequences, Nucleic Acid; Transforming Growth Factor beta | 1993 |
Antineurogenic phenotypes induced by truncated Notch proteins indicate a role in signal transduction and may point to a novel function for Notch in nuclei.
Topics: Animals; Animals, Genetically Modified; Cell Compartmentation; Cell Cycle Proteins; Cell Nucleus; Cysteine; DNA Mutational Analysis; Drosophila; Drosophila Proteins; Epidermal Growth Factor; Fungal Proteins; Genes, Insect; Immunohistochemistry; Insect Hormones; Membrane Proteins; Nerve Tissue; Peptide Fragments; Phenotype; Receptors, Notch; Repetitive Sequences, Nucleic Acid; Restriction Mapping; Schizosaccharomyces pombe Proteins; Sequence Deletion; Signal Transduction; Transcription Factors | 1993 |
Bovine latent transforming growth factor beta 1-binding protein 2: molecular cloning, identification of tissue isoforms, and immunolocalization to elastin-associated microfibrils.
Topics: Adaptor Proteins, Signal Transducing; Amino Acid Sequence; Animals; Base Sequence; Carrier Proteins; Cattle; Chromosome Mapping; Chromosomes, Human, Pair 14; Cloning, Molecular; Cysteine; DNA Primers; Elastin; Epidermal Growth Factor; Humans; In Situ Hybridization, Fluorescence; Intracellular Signaling Peptides and Proteins; Latent TGF-beta Binding Proteins; Microbodies; Molecular Sequence Data; Polymerase Chain Reaction; Sequence Homology, Amino Acid | 1995 |
Association of the small latent transforming growth factor-beta with an eight cysteine repeat of its binding protein LTBP-1.
Topics: Amino Acid Sequence; Animals; Binding Sites; Carrier Proteins; Cell Line; Chlorocebus aethiops; CHO Cells; Cricetinae; Cysteine; Disulfides; Electrophoresis, Polyacrylamide Gel; Epidermal Growth Factor; Extracellular Matrix; Extracellular Matrix Proteins; Humans; Intracellular Signaling Peptides and Proteins; Kidney; Latent TGF-beta Binding Proteins; Models, Structural; Molecular Sequence Data; Polymerase Chain Reaction; Recombinant Proteins; Repetitive Sequences, Nucleic Acid; Transfection; Transforming Growth Factor beta | 1996 |
Role of mitogen-activated protein kinase kinase in regulation of the epidermal growth factor receptor by protein kinase C.
Topics: 3T3 Cells; Animals; CHO Cells; Cricetinae; Cysteine; Down-Regulation; Enzyme Activation; Epidermal Growth Factor; ErbB Receptors; Mice; Mitogen-Activated Protein Kinase Kinases; Mutagenesis, Site-Directed; Phorbol 12,13-Dibutyrate; Phosphorylation; Protein Binding; Protein Kinase C; Protein Kinase Inhibitors; Protein Kinases; Signal Transduction; Terpenes; Thapsigargin; Tyrosine | 1996 |
Locating the unpaired cysteine of tissue-type plasminogen activator.
Topics: Amino Acid Sequence; Animals; Antibodies, Monoclonal; Binding Sites; Cell Line; Computer Graphics; Cricetinae; Cysteine; Embryo, Mammalian; Epidermal Growth Factor; Fibrin; Genetic Variation; Humans; Kidney; Mice; Mice, Inbred ICR; Models, Molecular; Molecular Sequence Data; Mutagenesis, Site-Directed; Point Mutation; Protein Structure, Secondary; Recombinant Proteins; Sequence Homology, Amino Acid; Tissue Plasminogen Activator; Transfection | 1996 |
Steric constraints in the recognition of peptide substrates for the epidermal growth factor receptor kinase.
Topics: Binding Sites; Cysteine; Epidermal Growth Factor; ErbB Receptors; Fluoresceins; Fluorescent Dyes; Iodoacetamide; Kinetics; Mass Spectrometry; Molecular Weight; Oligopeptides; Phosphorylation; Protein Conformation; Signal Transduction; Substrate Specificity; Tyrosine | 1996 |
Chemical synthesis and characterization of the epidermal growth factor-like module of human complement protease C1r.
Topics: Amino Acid Sequence; Binding Sites; Calcium; Chromatography, High Pressure Liquid; Chymotrypsin; Complement C1r; Complement C1s; Cysteine; Disulfides; Epidermal Growth Factor; Humans; Magnetic Resonance Spectroscopy; Mass Spectrometry; Molecular Sequence Data; Oxidation-Reduction; Peptide Fragments; Peptide Mapping; Protein Binding; Protein Folding; Structure-Activity Relationship | 1997 |
Reversible inactivation of protein-tyrosine phosphatase 1B in A431 cells stimulated with epidermal growth factor.
Topics: Amino Acid Sequence; Cell Line; Cysteine; Epidermal Growth Factor; Humans; Hydrogen Peroxide; Kinetics; Molecular Sequence Data; Molecular Weight; Placenta; Protein Tyrosine Phosphatases; Recombinant Proteins; Tumor Cells, Cultured | 1998 |
Kinetic studies of FR-1, a growth factor-inducible aldo-keto reductase.
Topics: Aldehyde Reductase; Aldehydes; Amino Acid Substitution; Animals; Binding Sites; Cysteine; Enzyme Activation; Epidermal Growth Factor; Growth Substances; Kinetics; Mass Spectrometry; Mice; Mutagenesis, Site-Directed; Protein Biosynthesis; Proteins; Serine; Substrate Specificity | 1998 |
Probing cellular protein targets of H2O2 with fluorescein-conjugated iodoacetamide and antibodies to fluorescein.
Topics: Antibodies; Blotting, Western; Catecholamines; Cysteine; Epidermal Growth Factor; Fluoresceins; Humans; Hydrogen Peroxide; Hydrogen-Ion Concentration; Imidazolines; Molecular Weight; Oxidants; Oxidation-Reduction; Papain; Phosphorylation; Phosphotyrosine; Precipitin Tests; Protein Tyrosine Phosphatases; Proteins; Substrate Specificity; Tumor Cells, Cultured | 1998 |
Differential effects of EGF on repair of cellular functions after dichlorovinyl-L-cysteine-induced injury.
Topics: Animals; Cell Division; Cysteine; Epidermal Growth Factor; Female; Intracellular Membranes; Kidney Diseases; Kidney Tubules, Proximal; Microvilli; Mitochondria; Oxygen Consumption; Rabbits; Regeneration; Wound Healing | 1999 |
Role of the 6-20 disulfide bridge in the structure and activity of epidermal growth factor.
Topics: Chromatography, High Pressure Liquid; Cysteine; Disulfides; Epidermal Growth Factor; Hydrogen-Ion Concentration; Magnetic Resonance Spectroscopy; Mass Spectrometry; Models, Molecular; Models, Statistical; Molecular Structure; Mutagenesis; Sequence Homology, Amino Acid; Structure-Activity Relationship; Temperature | 1998 |
Structure-function studies of FR-1. A growth factor-inducible aldo-keto reductase.
Topics: Aldehyde Reductase; Aldehydes; Cysteine; Epidermal Growth Factor; Fibroblast Growth Factor 1; Fibroblast Growth Factor 2; Gene Expression; Humans; Kinetics; Proteins; Structure-Activity Relationship | 1999 |
Structure-function analysis of the ADAM family of disintegrin-like and metalloproteinase-containing proteins (review).
Topics: Amino Acid Sequence; Animals; Cell Adhesion; Cysteine; Disintegrins; Epidermal Growth Factor; Evolution, Molecular; Fertilization; Humans; Metalloendopeptidases; Molecular Sequence Data; Organ Specificity; Protein Precursors; Protein Sorting Signals; Sequence Alignment; Signal Transduction; Structure-Activity Relationship; Zinc | 1999 |
Cysteine substitutions in epidermal growth factor-like domains of fibrillin-1: distinct effects on biochemical and clinical phenotypes.
Topics: Adolescent; Adult; Age of Onset; Aged; Alleles; Amino Acid Substitution; Cells, Cultured; Child; Child, Preschool; Cysteine; Disulfides; DNA Mutational Analysis; Epidermal Growth Factor; Exons; Fibrillin-1; Fibrillins; Fibroblasts; Genes, Lethal; Genotype; Humans; Infant, Newborn; Marfan Syndrome; Microfilament Proteins; Middle Aged; Molecular Sequence Data; Mutation; Phenotype; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger | 1999 |
Structural conversion from non-native to native form of recombinant human epidermal growth factor by Brevibacillus choshinensis.
Topics: Bacillus; Cysteine; Epidermal Growth Factor; Glutathione; Humans; Hydrogen-Ion Concentration; Kinetics; Macromolecular Substances; Protein Disulfide Reductase (Glutathione); Protein Processing, Post-Translational; Recombinant Proteins; Thermodynamics | 1999 |
A comparison of folding techniques in the chemical synthesis of the epidermal growth factor-like domain in neu differentiation factor alpha/beta.
Topics: Amino Acid Sequence; Amino Acids; Chromatography, High Pressure Liquid; Cysteine; Disulfides; Epidermal Growth Factor; Mass Spectrometry; Molecular Sequence Data; Neuregulin-1; Peptide Biosynthesis; Peptides; Protein Folding; Protein Structure, Tertiary; Sequence Homology, Amino Acid; Time Factors | 2000 |
Sprouty proteins are targeted to membrane ruffles upon growth factor receptor tyrosine kinase activation. Identification of a novel translocation domain.
Topics: Amino Acid Sequence; Animals; Cell Line; Cell Membrane; Conserved Sequence; COS Cells; Cysteine; Drosophila; Drosophila Proteins; Enzyme Activation; Epidermal Growth Factor; ErbB Receptors; Humans; Insect Proteins; Membrane Proteins; Mice; Microtubules; Molecular Sequence Data; Nerve Tissue Proteins; Phosphatidylinositol 3-Kinases; Receptor Protein-Tyrosine Kinases; Recombinant Proteins; Sequence Alignment; Sequence Homology, Amino Acid; Transfection | 2000 |
An animal model for the molecular genetics of CADASIL. (Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy).
Topics: Animals; Anura; Arteries; Arterioles; Cell Differentiation; Cell Division; Collagen; Cysteine; Dementia, Multi-Infarct; Disease Models, Animal; Drosophila melanogaster; Epidermal Growth Factor; Genes, Dominant; Genes, Lethal; Genetic Linkage; Humans; Mice; Muscle, Smooth, Vascular; Mutation; Myosins; Nerve Fibers, Myelinated; Organ Specificity; Phenotype; Protein Structure, Tertiary; Proto-Oncogene Proteins; Receptor, Notch3; Receptor, Notch4; Receptors, Cell Surface; Receptors, Notch; Signal Transduction | 2001 |
Phosphorylation of the protein kinase mutated in Peutz-Jeghers cancer syndrome, LKB1/STK11, at Ser431 by p90(RSK) and cAMP-dependent protein kinase, but not its farnesylation at Cys(433), is essential for LKB1 to suppress cell vrowth.
Topics: AMP-Activated Protein Kinase Kinases; AMP-Activated Protein Kinases; Animals; Binding Sites; Calcium-Calmodulin-Dependent Protein Kinases; Cell Division; Cell Line; Cloning, Molecular; Colforsin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Cysteine; Enzyme Activation; Enzyme Inhibitors; Epidermal Growth Factor; Glutathione Transferase; Humans; Immunoblotting; Isoquinolines; Mevalonic Acid; Mice; Models, Biological; Mutation; Peutz-Jeghers Syndrome; Phosphorylation; Precipitin Tests; Protein Prenylation; Protein Serine-Threonine Kinases; Rats; Ribosomal Protein S6 Kinases; Ribosomal Protein S6 Kinases, 90-kDa; Serine; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Sulfonamides; Time Factors; Transfection | 2001 |
Phosphotyrosines 627 and 659 of Gab1 constitute a bisphosphoryl tyrosine-based activation motif (BTAM) conferring binding and activation of SHP2.
Topics: Amino Acid Motifs; Animals; Binding Sites; COS Cells; Cysteine; Enzyme Activation; Epidermal Growth Factor; Intracellular Signaling Peptides and Proteins; Mitogen-Activated Protein Kinase 1; Mutation; Peptides; Phosphoproteins; Phosphotyrosine; Protein Binding; Protein Structure, Tertiary; Protein Tyrosine Phosphatase, Non-Receptor Type 11; Protein Tyrosine Phosphatase, Non-Receptor Type 6; Protein Tyrosine Phosphatases; Recombinant Fusion Proteins | 2001 |
Dipeptide frequency/bias analysis identifies conserved sites of nonrandomness shared by cysteine-rich motifs.
Topics: Amino Acid Motifs; Computational Biology; Conserved Sequence; Cysteine; Databases, Factual; Dipeptides; Epidermal Growth Factor; Glycine; Laminin; Models, Molecular | 2001 |
Definition of EGF-like, closely interacting modules that bear activation epitopes in integrin beta subunits.
Topics: Amino Acid Sequence; Animals; Antibodies, Monoclonal; Antigens, Differentiation, T-Lymphocyte; Cell Line; Cysteine; Disulfides; Enzyme-Linked Immunosorbent Assay; Epidermal Growth Factor; Epitopes; Humans; Integrins; Mice; Molecular Sequence Data; Protein Structure, Secondary; Protein Subunits; Recombinant Proteins; Repetitive Sequences, Amino Acid; Sequence Alignment; Sequence Homology, Amino Acid; T-Lymphocytes; Transfection | 2001 |
Structure-function analysis of the EGF-CFC family member Cripto identifies residues essential for nodal signalling.
Topics: Amino Acid Sequence; Animals; Binding Sites; Computer Simulation; Cysteine; Embryonic Induction; Epidermal Growth Factor; Genetic Complementation Test; Homeodomain Proteins; Models, Molecular; Molecular Sequence Data; Neoplasm Proteins; Point Mutation; Protein Binding; Protein Structure, Tertiary; Recombinant Proteins; Sequence Homology, Amino Acid; Transcription Factors; Zebrafish; Zebrafish Proteins | 2001 |
A specific binding site for a fragment of the B-loop of epidermal growth factor and related peptides.
Topics: Amino Acid Sequence; Binding Sites; Cell Line; Cell Membrane; Cysteine; Dose-Response Relationship, Drug; Epidermal Growth Factor; ErbB Receptors; Humans; Ligands; Molecular Sequence Data; Peptide Biosynthesis; Peptides; Protein Binding; Protein Structure, Secondary; Protein Structure, Tertiary; Sequence Homology, Amino Acid; Tumor Cells, Cultured | 2002 |
Redox regulation of protein tyrosine phosphatases by hydrogen peroxide: detecting sulfenic acid intermediates and examining reversible inactivation.
Topics: 4-Chloro-7-nitrobenzofurazan; Catalytic Domain; Cell Line; Cysteine; Enzyme Inhibitors; Epidermal Growth Factor; Glutathione; Humans; Hydrogen Peroxide; Hydrogen-Ion Concentration; Kinetics; Models, Biological; Oxidation-Reduction; Protein Tyrosine Phosphatases; Signal Transduction; Sulfenic Acids | 2002 |
The bimodal regulation of epidermal growth factor signaling by human Sprouty proteins.
Topics: Animals; Blotting, Western; CHO Cells; Cricetinae; Cysteine; DNA, Complementary; Down-Regulation; Drosophila Proteins; Epidermal Growth Factor; ErbB Receptors; HeLa Cells; Humans; Insect Proteins; Intracellular Signaling Peptides and Proteins; MAP Kinase Signaling System; Membrane Proteins; Mitogen-Activated Protein Kinase 1; Plasmids; Precipitin Tests; Protein Structure, Tertiary; Proteins; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-cbl; Signal Transduction; Time Factors; Transcription, Genetic; Transfection; Ubiquitin; Ubiquitin-Protein Ligases | 2002 |
Membrane association and dimerization of a cysteine-rich, 16-kilodalton polypeptide released from the C-terminal region of the coronavirus infectious bronchitis virus 1a polyprotein.
Topics: Amino Acid Sequence; Animals; Base Sequence; Cell Membrane; Chlorocebus aethiops; COS Cells; Cysteine; Dimerization; Epidermal Growth Factor; Infectious bronchitis virus; Molecular Sequence Data; Peptides; Polyproteins; Vero Cells; Viral Proteins | 2002 |
A novel approach to the synthesis of EGF-like domains: a method for the one-pot regioselective formation of the three disulfide bonds of a human blood coagulation factor VII EGF-1 analogue.
Topics: Amino Acid Sequence; Aspartic Acid; Chromatography, High Pressure Liquid; Circular Dichroism; Cysteine; Disulfides; Epidermal Growth Factor; Factor VII; Humans; Molecular Sequence Data; Peptides; Protein Folding; Protein Structure, Secondary; Protein Structure, Tertiary; Sequence Homology, Amino Acid; Spectrometry, Mass, Electrospray Ionization; Structure-Activity Relationship | 2002 |
Extracellular thiol/disulfide redox state affects proliferation rate in a human colon carcinoma (Caco2) cell line.
Topics: Bromodeoxyuridine; Cell Division; Chromatography, High Pressure Liquid; Culture Media; Cysteine; Cystine; Disulfides; DNA; Epidermal Growth Factor; Extracellular Matrix; Free Radicals; Humans; Insulin-Like Growth Factor I; Intestinal Mucosa; Models, Biological; Oxidation-Reduction; Signal Transduction; Time Factors; Tumor Cells, Cultured | 2002 |
Redox regulation of protein tyrosine phosphatase 1B involves a sulphenyl-amide intermediate.
Topics: Amides; Amino Acid Substitution; Binding Sites; Cysteine; Epidermal Growth Factor; Insulin; Models, Molecular; Oxidation-Reduction; Phosphorylation; Protein Binding; Protein Conformation; Protein Tyrosine Phosphatase, Non-Receptor Type 1; Protein Tyrosine Phosphatases; Receptor, Insulin; Serine; Sulfenic Acids | 2003 |
Identification and characterization of AMACO, a new member of the von Willebrand factor A-like domain protein superfamily with a regulated expression in the kidney.
Topics: Amino Acid Sequence; Animals; Base Sequence; Basement Membrane; Biomarkers, Tumor; Blotting, Northern; Calcium-Binding Proteins; Cartilage; Cell Line; Chondrocytes; Cysteine; DNA, Complementary; Electrophoresis, Polyacrylamide Gel; Epidermal Growth Factor; Epithelial Cells; Extracellular Matrix Proteins; Fibroblasts; Gene Expression Regulation; Humans; In Situ Hybridization; Keratinocytes; Kidney; Lung; Mice; Mice, Inbred C57BL; Microscopy, Electron; Microscopy, Fluorescence; Models, Genetic; Molecular Sequence Data; Multigene Family; Oligonucleotides, Antisense; Peptides; Plasmids; Protein Structure, Tertiary; Recombinant Proteins; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sequence Homology, Amino Acid; Tissue Distribution; Transcription Factors; von Willebrand Factor | 2003 |
Critical cysteine residues for regulation of integrin alphaIIbbeta3 are clustered in the epidermal growth factor domains of the beta3 subunit.
Topics: Animals; CHO Cells; Cricetinae; Cricetulus; Cysteine; Disulfides; Epidermal Growth Factor; Fibrinogen; Humans; Integrin beta3; Mutagenesis, Site-Directed; Platelet Glycoprotein GPIIb-IIIa Complex; Protein Structure, Tertiary | 2004 |
Consequences of cysteine mutations in calcium-binding epidermal growth factor modules of fibrillin-1.
Topics: Amino Acid Sequence; Blotting, Western; Calcium; Cell Line; Circular Dichroism; Cysteine; Epidermal Growth Factor; Epitope Mapping; Fibrillin-1; Fibrillins; Humans; Microfilament Proteins; Microscopy, Electron; Molecular Sequence Data; Mutation; Mutation, Missense; Peptides; Plasmids; Protein Structure, Secondary; Protein Structure, Tertiary; Recombinant Proteins; RNA, Messenger; Temperature; Transfection; Ultraviolet Rays | 2004 |
Structural consequences of cysteine substitutions C1977Y and C1977R in calcium-binding epidermal growth factor-like domain 30 of human fibrillin-1.
Topics: Amino Acid Sequence; Binding Sites; Calcium; Chelating Agents; Cloning, Molecular; Cysteine; Disulfides; DNA; Dose-Response Relationship, Drug; Egtazic Acid; Epidermal Growth Factor; Fibrillin-1; Fibrillins; Humans; Kinetics; Magnetic Resonance Spectroscopy; Microfilament Proteins; Models, Molecular; Molecular Sequence Data; Mutation; Protein Binding; Protein Conformation; Protein Folding; Protein Structure, Tertiary; Protein Transport; Recombinant Proteins; Spectrometry, Mass, Electrospray Ionization; Time Factors; Trypsin | 2004 |
Folding of epidermal growth factor-like repeats from human tenascin studied through a sequence frame-shift approach.
Topics: Amino Acid Sequence; Chromatography, High Pressure Liquid; Chromatography, Liquid; Circular Dichroism; Cysteine; Disulfides; Epidermal Growth Factor; Extracellular Matrix; Humans; Kinetics; Magnetic Resonance Spectroscopy; Mass Spectrometry; Models, Molecular; Molecular Sequence Data; Mutagenesis; Oxygen; Peptides; Protein Folding; Tenascin; Thermodynamics; Time Factors | 2004 |
In vitro maturation of porcine oocytes using a defined medium and developmental capacity after intracytoplasmic sperm injection.
Topics: Amino Acids; Animals; Blastocyst; Culture Media; Cysteine; Embryonic Development; Epidermal Growth Factor; Female; Glutathione; Male; Oocytes; Polyvinyl Alcohol; Sperm Injections, Intracytoplasmic; Swine; Tissue Culture Techniques | 2004 |
Structural bioinformatics-based design of selective, irreversible kinase inhibitors.
Topics: Amino Acid Sequence; Animals; Binding Sites; Computational Biology; COS Cells; Cysteine; Cytidine Deaminase; Enzyme Inhibitors; Epidermal Growth Factor; Heterocyclic Compounds, 2-Ring; Histones; Hydrophobic and Hydrophilic Interactions; Molecular Structure; Mutation; Phosphorylation; Protein Structure, Tertiary; Ribosomal Protein S6 Kinases, 90-kDa; Sequence Alignment; Serine; Structure-Activity Relationship; Threonine | 2005 |
The role of disulfide bonds in the structure and function of murine epidermal growth factor (mEGF).
Topics: Amino Acid Sequence; Aminobutyrates; Animals; Chromatography, High Pressure Liquid; Circular Dichroism; Cysteine; Disulfides; Epidermal Growth Factor; Humans; Hydrogen-Ion Concentration; Magnetic Resonance Spectroscopy; Mass Spectrometry; Mice; Mice, Inbred BALB C; Models, Molecular; Molecular Sequence Data; Oxygen; Peptides; Protein Folding; Protein Structure, Tertiary; Sequence Homology, Amino Acid; Time Factors | 2005 |
Tenascin-C is involved in motor axon outgrowth in the trunk of developing zebrafish.
Topics: Amino Acid Sequence; Animals; Axons; Cell Differentiation; Cloning, Molecular; Cysteine; DNA, Complementary; Epidermal Growth Factor; Gene Expression Regulation, Developmental; Humans; Immunohistochemistry; Molecular Sequence Data; Motor Neurons; Mutation; RNA, Messenger; Sequence Alignment; Sequence Homology, Amino Acid; Tenascin; Zebrafish | 2005 |
Distinct protein classes including novel merozoite surface antigens in Raft-like membranes of Plasmodium falciparum.
Topics: Amino Acid Motifs; Animals; Antigens, Protozoan; Antigens, Surface; Cell Membrane; Cysteine; Detergents; Epidermal Growth Factor; Erythrocytes; Glycosylphosphatidylinositols; Green Fluorescent Proteins; Membrane Microdomains; Merozoite Surface Protein 1; Models, Biological; Plasmodium falciparum; Protein Binding; Protein Structure, Tertiary; Proteins; Proteomics; Protozoan Proteins | 2005 |
Src homology 2-containing phosphotyrosine phosphatase regulates endothelin-1-induced epidermal growth factor receptor transactivation in rat renal tubular cell NRK-52E.
Topics: Animals; Cell Line; Cysteine; Endothelin-1; Epidermal Growth Factor; Intracellular Signaling Peptides and Proteins; Kidney Tubules; Oxidation-Reduction; Protein Tyrosine Phosphatase, Non-Receptor Type 11; Protein Tyrosine Phosphatases; Rats; Reactive Oxygen Species; SH2 Domain-Containing Protein Tyrosine Phosphatases; Signal Transduction; src Homology Domains; Transcriptional Activation | 2006 |
Isomers of epidermal growth factor with Ser --> Cys mutation at the N-terminal sequence: isomerization, stability, unfolding, refolding, and structure.
Topics: Amino Acid Sequence; Cysteine; Disulfides; Epidermal Growth Factor; Humans; Isomerism; Models, Molecular; Molecular Sequence Data; Mutagenesis, Site-Directed; Mutation; Protein Conformation; Protein Denaturation; Protein Folding; Serine | 2005 |
Palmitoylation of the EGFR ligand Spitz by Rasp increases Spitz activity by restricting its diffusion.
Topics: Acyltransferases; Animals; Base Sequence; Biological Transport, Active; Cell Line; Cell Membrane; Cysteine; DNA; Drosophila; Drosophila Proteins; Epidermal Growth Factor; ErbB Receptors; Female; Genes, Insect; In Vitro Techniques; Ligands; Male; Membrane Proteins; Models, Biological; Mutagenesis, Site-Directed; Mutation; Ovary; Palmitic Acid; Recombinant Proteins; Transfection; Wings, Animal | 2006 |
Cysteine-rich domains of muc3 intestinal mucin promote cell migration, inhibit apoptosis, and accelerate wound healing.
Topics: Amino Acid Sequence; Animals; Apoptosis; Cell Movement; Cell Proliferation; Cells, Cultured; Cysteine; Epidermal Growth Factor; ErbB Receptors; Humans; Mice; Molecular Sequence Data; Mucin-3; Mucins; Protein Structure, Tertiary; Recombinant Proteins; Wound Healing | 2006 |
Blastocyst production by in vitro maturation and development of porcine oocytes in defined media following intracytoplasmic sperm injection.
Topics: Animals; Blastocyst; Culture Media; Cysteine; Embryonic Development; Epidermal Growth Factor; Female; Fertilization in Vitro; Glutathione; Male; Oocytes; Pregnancy; Sperm Injections, Intracytoplasmic; Spermatocytes; Swine; Tissue Culture Techniques | 2007 |
S-Nitrosylation of the epidermal growth factor receptor: a regulatory mechanism of receptor tyrosine kinase activity.
Topics: Catalytic Domain; Cell Line, Tumor; Cell Proliferation; Cysteine; Epidermal Growth Factor; ErbB Receptors; Feedback, Physiological; Humans; Mutagenesis, Site-Directed; Mutation; Neuroblastoma; Nitric Oxide; Nitric Oxide Synthase; Oxidative Phosphorylation; Quaternary Ammonium Compounds; Receptor Protein-Tyrosine Kinases; Signal Transduction; Transgenes | 2009 |
Interactions among the epidermal growth factor-like modules of thrombospondin-1.
Topics: Calorimetry; Circular Dichroism; Cloning, Molecular; Crystallography, X-Ray; Cysteine; Dose-Response Relationship, Drug; Epidermal Growth Factor; Humans; Kinetics; Molecular Conformation; Protein Binding; Protein Conformation; Recombinant Proteins; Temperature; Thrombospondin 1 | 2009 |
A novel disulfide pattern in laminin-type epidermal growth factor-like (LE) modules of laminin β1 and γ1 chains.
Topics: Animals; Binding Sites; Cysteine; Disulfides; Epidermal Growth Factor; Laminin; Mice; Protein Binding; Protein Structure, Tertiary | 2010 |
Thiols stabilize cobblestone morphology of cultured mesothelial cells.
Topics: Cell Culture Techniques; Cell Differentiation; Cell Proliferation; Cell Shape; Cells, Cultured; Cysteine; Epidermal Growth Factor; Epithelial Cells; Epithelial-Mesenchymal Transition; Epithelium; Glutathione; Humans; Mercaptoethanol; Microscopy, Electron; Microscopy, Phase-Contrast; Oxidative Stress; Peritoneum; Phenotype; Reactive Oxygen Species; Signal Transduction; Sulfhydryl Compounds | 2011 |
Bipartite tetracysteine display reveals allosteric control of ligand-specific EGFR activation.
Topics: Allosteric Site; Animals; Binding Sites; Biochemistry; Cell Membrane; CHO Cells; Cricetinae; Cysteine; Dimerization; Epidermal Growth Factor; ErbB Receptors; Humans; Ligands; Protein Binding; Protein Structure, Tertiary; Transforming Growth Factor alpha | 2012 |
90-kDa ribosomal S6 kinase 1 is inhibited by S-glutathionylation of its active-site cysteine residue during oxidative stress.
Topics: Animals; Brain; Catalytic Domain; Cysteine; Diamide; Epidermal Growth Factor; Glutathione; HEK293 Cells; Humans; Kinetics; Mice; Nitric Oxide Synthase Type I; Oxidative Stress; Phosphorylation; Protein Processing, Post-Translational; Ribosomal Protein S6 Kinases, 90-kDa | 2013 |
EGF-induced centrosome separation promotes mitotic progression and cell survival.
Topics: Cell Proliferation; Cell Survival; Centrosome; Cysteine; DNA Replication; Enzyme Activation; Epidermal Growth Factor; ErbB Receptors; HeLa Cells; Humans; Kinesins; Mitosis; NIMA-Related Kinases; Protein Serine-Threonine Kinases; S Phase Cell Cycle Checkpoints; Serine-Threonine Kinase 3; Signal Transduction; Spindle Apparatus; Time Factors; Transfection | 2013 |
Site-specific protection and dual labeling of human epidermal growth factor (hEGF) for targeting, imaging, and cargo delivery.
Topics: Cysteine; Diagnostic Imaging; Drug Delivery Systems; Epidermal Growth Factor; Humans; Models, Molecular; Molecular Probes; Protein Engineering; Protein Folding; Recombinant Fusion Proteins; Thiazolidines | 2014 |
Site-specific mapping and quantification of protein S-sulphenylation in cells.
Topics: Acetylation; Cell Line, Tumor; Cysteine; Epidermal Growth Factor; Epithelial Cells; Gene Expression; Humans; Hydrogen Peroxide; Hypoxia-Inducible Factor 1, alpha Subunit; Molecular Sequence Annotation; Oxidation-Reduction; Peptide Mapping; Phosphorylation; Protein Processing, Post-Translational; Sirtuins; Sulfenic Acids; Ubiquitination | 2014 |
Involvement of de novo synthesized palmitate and mitochondrial EGFR in EGF induced mitochondrial fusion of cancer cells.
Topics: Breast Neoplasms; Cell Line, Tumor; Cysteine; Drug Resistance; Epidermal Growth Factor; ErbB Receptors; Fatty Acid Synthase, Type I; Female; Humans; Male; Mitochondria; Mitochondrial Dynamics; Mitochondrial Proteins; Palmitates; Prohibitins; Prostatic Neoplasms; Protein Array Analysis; Protein Kinase Inhibitors; Protein-Tyrosine Kinases | 2014 |
Inhibition of DHHC20-Mediated EGFR Palmitoylation Creates a Dependence on EGFR Signaling.
Topics: Acyltransferases; Animals; Antineoplastic Agents; Breast Neoplasms; Cell Death; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cysteine; Endocytosis; Epidermal Growth Factor; ErbB Receptors; Gefitinib; GRB2 Adaptor Protein; HEK293 Cells; Humans; Lipoylation; Mass Spectrometry; Mice; Mutation; NIH 3T3 Cells; Protein Conformation; Protein Kinase Inhibitors; Protein Processing, Post-Translational; Protein Transport; Proteolysis; Quinazolines; RNA Interference; Signal Transduction; Structure-Activity Relationship; Transfection | 2016 |
Simultaneous Enrichment of Cysteine-containing Peptides and Phosphopeptides Using a Cysteine-specific Phosphonate Adaptable Tag (CysPAT) in Combination with titanium dioxide (TiO2) Chromatography.
Topics: Chromatography, Liquid; Cysteine; Epidermal Growth Factor; ErbB Receptors; HeLa Cells; Humans; Isotope Labeling; Organophosphonates; Peptides; Phosphopeptides; Phosphorylation; Proteomics; Signal Transduction; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Titanium | 2016 |
IKKα regulates human keratinocyte migration through surveillance of the redox environment.
Topics: Amino Acid Sequence; Animals; Cell Line; Cell Movement; Cysteine; Epidermal Growth Factor; Humans; Hydrogen Peroxide; I-kappa B Kinase; Keratinocytes; Oxidation-Reduction; Promoter Regions, Genetic; Protein Processing, Post-Translational; Signal Transduction; Wound Healing; Zebrafish | 2017 |
The interface between the EGF1 and EGF2 domains is critical in integrin affinity regulation.
Topics: Binding Sites; Cell Adhesion; Chimera; Coordination Complexes; Crystallography; Cysteine; Epidermal Growth Factor; Extracellular Matrix; HEK293 Cells; Humans; Integrin beta Chains; Integrin beta3; Ligands; Microscopy, Confocal; Protein Binding; Protein Conformation; Protein Domains; Signal Transduction | 2018 |
Expression analysis and functional characterization of the mouse cysteine-rich with EGF-like domains 2.
Topics: Animals; Cell Adhesion Molecules; Cell Line; Cysteine; Endoplasmic Reticulum; Endoplasmic Reticulum Stress; Epidermal Growth Factor; Extracellular Matrix Proteins; Male; Mice; Mice, Inbred Strains; Thapsigargin; Transcription Factor CHOP; Transcriptome; Tunicamycin | 2018 |
Control of protein function through oxidation and reduction of persulfidated states.
Topics: Animals; Cysteine; Epidermal Growth Factor; Homeodomain Proteins; HSP90 Heat-Shock Proteins; Humans; Kelch-Like ECH-Associated Protein 1; Mice; Oxidation-Reduction; Protein Tyrosine Phosphatase, Non-Receptor Type 1; PTEN Phosphohydrolase; Selenium; Signal Transduction; Sulfides; Thioredoxin Reductase 1; Thioredoxins | 2020 |
Spatial and temporal alterations in protein structure by EGF regulate cryptic cysteine oxidation.
Topics: Cell Line, Tumor; Cell Membrane; Crystallography, X-Ray; Cysteine; Epidermal Growth Factor; ErbB Receptors; Humans; Molecular Dynamics Simulation; Oxidation-Reduction; Phosphorylation; Protein Conformation; Reactive Oxygen Species; Signal Transduction; Time Factors | 2020 |
Trans-Reduction of Cerebral Small Vessel Disease Proteins by Notch-Derived EGF-like Sequences.
Topics: CADASIL; Cerebral Small Vessel Diseases; Cysteine; Epidermal Growth Factor; Humans; Mutation; Receptor, Notch3; Receptors, Notch | 2022 |
Plant produced endotoxin binding recombinant proteins effectively remove endotoxins from protein samples.
Topics: Arabidopsis; Cysteine; Endotoxins; Epidermal Growth Factor; Escherichia coli; Lipopolysaccharides; Plant Extracts; Recombinant Fusion Proteins; Recombinant Proteins; Solvents | 2022 |
Chemical synthesis of per-selenocysteine human epidermal growth factor.
Topics: Cysteine; Disulfides; Epidermal Growth Factor; Humans; Peptides; Protein Folding; Selenocysteine | 2023 |
Two Closed Conformations of CRAF Require the 14-3-3 Binding Motifs and Cysteine-Rich Domain to be Intact in Live Cells.
Topics: 14-3-3 Proteins; Amino Acid Motifs; Cysteine; Epidermal Growth Factor; HeLa Cells; Humans; Protein Binding; Protein Domains; Proto-Oncogene Proteins c-raf | 2023 |
Structural changes in NOTCH3 induced by CADASIL mutations: Role of cysteine and non-cysteine alterations.
Topics: CADASIL; Cysteine; Disulfides; Epidermal Growth Factor; Humans; Mutation; Receptor, Notch3 | 2023 |
A novel scavenger receptor (EcSRECII) as a lipopolysaccharide recognition molecule involved in regulating NF-κB activation through extracellular EGF-like cysteine-rich repeat domains with lysosomes in Epinephelus coioides.
Topics: Animals; Bass; Cysteine; Epidermal Growth Factor; Lipopolysaccharides; Lysosomes; Mammals; NF-kappa B; Receptors, Scavenger; Signal Transduction; Vibrio Infections | 2023 |