cynaropicrin has been researched along with sesquiterpenes in 45 studies
| Studies (cynaropicrin) | Trials (cynaropicrin) | Recent Studies (post-2010) (cynaropicrin) | Studies (sesquiterpenes) | Trials (sesquiterpenes) | Recent Studies (post-2010) (sesquiterpenes) |
|---|---|---|---|---|---|
| 53 | 0 | 41 | 17,489 | 536 | 7,668 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (6.67) | 18.2507 |
| 2000's | 7 (15.56) | 29.6817 |
| 2010's | 29 (64.44) | 24.3611 |
| 2020's | 6 (13.33) | 2.80 |
| Authors | Studies |
|---|---|
| Cheng, CH; Costall, B; Hamburger, M; Hostettmann, K; Jenner, P; Naylor, RJ; Wang, Y | 1 |
| Hamburger, M; Hay, AJ; Hostettmann, K; Hoult, JR | 1 |
| Baik, KU; Cho, JY; Jung, JH; Lee, J; Park, J; Park, MH; Yoo, ES | 1 |
| Baik, KU; Cho, JY; Jung, JH; Park, MH | 1 |
| Chain, BM; Cho, JY; Joo, HG; Jung, JH; Katz, DR; Kim, AR; Kim, BH; Rhee, MH; Yoo, ES | 1 |
| Cho, JY; Chun, T; Jung, JH; Kim, AR; Rhee, MH; Yoo, ES | 1 |
| Bellato, F; Cardozo, AM; Cechinel-Filho, V; Delle Monache, F; Emendörfer, F; Noldin, VF; Yunes, RA | 1 |
| Bachelier, A; Klein, CD; Mayer, R | 1 |
| Batsuren, D; Kang, K; Kim, CY; Lee, HJ; Lee, SB; Nho, CW; Tunsag, J | 1 |
| Bártlová, M; Opletal, L; Sajfrtová, M; Sovová, H | 1 |
| Pieri, V; Stuppner, H | 1 |
| Adams, M; Brun, R; Hamburger, M; Kaiser, M; Zimmermann, S | 1 |
| Beekwilder, J; Bouwmeester, HJ; Cankar, K; Comino, C; Lanteri, S; Menin, B; Moglia, A; Portis, E | 1 |
| Akao, Y; Hamada, T; Kojima, H; Masutani, T; Tanaka, K; Tanaka, YT; Tsuboi, M | 1 |
| Adams, M; Brun, R; Fouche, G; Hamburger, M; Hata, Y; Kaiser, M; Koorbanally, NA; Maharaj, V; Mokoka, TA; Moodley, N; Xolani, PK; Zimmermann, S | 1 |
| Adams, M; Batista, Dda G; Batista, MM; Brun, R; da Silva, CF; da Silva, PB; De Araújo, JS; De Mieri, M; de Souza, EM; Hamburger, M; Hammer, ER; Lionel, J; Schühly, W; Soeiro, Mde N; Zimmermann, S | 1 |
| Adams, M; Becker, K; Brun, R; Hamburger, M; Kaiser, M; Krauth-Siegel, RL; Leroux, A; Oufir, M; Zimmermann, S | 1 |
| Butturini, E; Carcereri de Prati, A; Cavalieri, E; Chiavegato, G; Darra, E; Mariotto, S; Rigo, A | 1 |
| Adams, M; Brun, R; Hamburger, M; Hara, S; Kaiser, M; Kondo, R; Sato, M; Usuki, T; Yoshimoto, Y; Zimmermann, S | 1 |
| Furue, M; Hashimoto-Hachiya, A; Nakahara, T; Takahara, M; Takei, K; Tsuji, G | 1 |
| Furue, M; Ishii, Y; Kuroki, H; Mitoma, C; Takeda, T; Uchi, H; Yamada, H; Yamada, K | 1 |
| Beekwilder, J; Bourgaud, F; Cankar, K; Comino, C; Eljounaidi, K; Genre, A; Hehn, A; Lanteri, S; Moglia, A | 1 |
| Abdel-Azim, NS; Alsaid, MS; El Halawany, AM; Hegazy, ME; Ibrahim, AY; Mohamed, TA; Paré, PW; Shahat, AA | 1 |
| Adams, M; Hara, S; Ogawa, K; Sato, M; Sato, T; Usuki, T | 1 |
| Diez, J; Elsebai, MF; Fontaine-Vive, F; Koutsoudakis, G; Mattila, S; Mehiri, M; Meyerhans, A; Pérez-Vilaró, G; Pirttilä, AM; Saludes, V; Turpeinen, A | 1 |
| Hara, A; Kojima, H; Masutani, T; Niwa, M; Tanaka, YT; Tsuboi, M | 1 |
| García, BF; Macías, FA; Molinillo, JM; Rial, C; Torres, A; Varela, RM | 1 |
| Borborema, SET; Costa-Silva, TA; Da Costa, FB; Galuppo, MK; Lima, ML; Mesquita, JT; Schmidt, TJ; Taniwaki, NN; Tempone, AG; Wulsten, IF | 1 |
| Chianese, G; Efferth, T; Formisano, C; Rigano, D; Seo, EJ; Sirignano, C; Taglialatela-Scafati, O; Zengin, G | 1 |
| Carev, I; Čulić, VČ; Politeo, O; Radan, M; Tešević, V | 1 |
| Amini, E; Asili, J; Iranshahi, M; Masullo, M; Piacente, S; Shakeri, A | 1 |
| Cláudio, AFM; de Faria, ELP; do Carmo, RS; Freire, CSR; Freire, MG; Silvestre, AJD | 1 |
| Brás, T; Capel, C; Capel, J; Duarte, MF; Ferro, AM; Gonçalves, S; Guerra, Â; Guerreiro, O; Jerónimo, E; Lozano, R; Oliveira, MM; Parreira, P; Ramos, P; Yuste-Lisbona, FJ | 1 |
| Colantuono, A; Ferracane, R; Vitaglione, P | 1 |
| Boorsma, CE; Draijer, C; Hylkema, MN; Melgert, BN; Robbe, P | 1 |
| Hayata, M; Iddamalgoda, A; Imai, K; Kamio, N; Nodomi, K; Ogata, Y; Sato, S; Tamura, M; Tanaka, K; Tsuda, H; Ueda, K; Watanabe, N | 1 |
| Bulotta, S; Celano, M; Lepore, SM; Lombardo, GE; Maggisano, V; Maiuolo, J; Mollace, V; Russo, D | 1 |
| Fang, J; Han, X; Liu, T; Wu, Y; Xu, J; Zhang, J | 1 |
| Kurita, M; Li, J; Usuki, T; Yoshida, Y | 1 |
| Alves, VD; Brás, T; Crespo, JG; Duarte, MF; Gomes, AC; Gonçalves, AC; Neves, LA; Rosa, D | 1 |
| Allegra, M; Busà, R; De Cicco, P; Ercolano, G; Formisano, C; Ianaro, A; Taglialatela-Scafati, O | 1 |
| Ando, T; Hattori, Y; Matsuda, H; Matsumoto, T; Nakamura, S; Nakashima, S | 1 |
| Cai, D; Cheng, Z; Duan, H; Fu, Y | 1 |
| Chen, F; Ding, Z; Fang, J; Xi, J; Zhang, B; Zhao, H; Zhong, M | 1 |
| Jin, T; Leng, B | 1 |
45 other study(ies) available for cynaropicrin and sesquiterpenes
| Article | Year |
|---|---|
Toxic effects of solstitialin A 13-acetate and cynaropicrin from Centaurea solstitialis L. (Asteraceae) in cell cultures of foetal rat brain.
Topics: Animals; Brain; Cells, Cultured; Female; Lactones; Phorbols; Plant Extracts; Plants; Pregnancy; Rats; Rats, Inbred Strains; Sesquiterpenes | 1992 |
Toxic inhibition of smooth muscle contractility by plant-derived sesquiterpenes caused by their chemically reactive alpha-methylenebutyrolactone functions.
Topics: Animals; Aorta, Thoracic; Chromatography, High Pressure Liquid; Cysteine; In Vitro Techniques; Lactones; Male; Muscle Contraction; Muscle, Smooth, Vascular; Phenylephrine; Phorbols; Plants; Rabbits; Sesquiterpenes | 1994 |
Inhibitory effect of sesquiterpene lactones from Saussurea lappa on tumor necrosis factor-alpha production in murine macrophage-like cells.
Topics: Animals; Cell Line; Lactones; Mice; Molecular Structure; Plants, Medicinal; Sesquiterpenes; Tumor Necrosis Factor-alpha | 1998 |
In vitro anti-inflammatory effects of cynaropicrin, a sesquiterpene lactone, from Saussurea lappa.
Topics: Animals; Anti-Inflammatory Agents; Cell Line; Cell Survival; Cytotoxins; Humans; Lactones; Lymphocytes; Male; Mice; Mice, Inbred BALB C; Nitric Oxide; Sesquiterpenes; Tumor Necrosis Factor-alpha | 2000 |
Cynaropicrin, a sesquiterpene lactone, as a new strong regulator of CD29 and CD98 functions.
Topics: Antigens, CD; Cell Aggregation; Fusion Regulatory Protein-1; Humans; Integrin beta1; Lactones; Leukosialin; Macrophages; MAP Kinase Signaling System; Mitogen-Activated Protein Kinases; Phosphorylation; Sesquiterpenes; Sialoglycoproteins; Tyrosine; U937 Cells | 2004 |
Cytotoxic and pro-apoptotic activities of cynaropicrin, a sesquiterpene lactone, on the viability of leukocyte cancer cell lines.
Topics: Antineoplastic Agents; Apoptosis; Cell Cycle; Cell Line, Tumor; Cell Survival; DNA Fragmentation; Flow Cytometry; Humans; L-Lactate Dehydrogenase; Lactones; Leukocytes; Microscopy, Phase-Contrast; Protein Kinase C; Reactive Oxygen Species; Sesquiterpenes | 2004 |
Antispasmodic activity of fractions and cynaropicrin from Cynara scolymus on guinea-pig ileum.
Topics: Animals; Cynara scolymus; Dose-Response Relationship, Drug; Female; Guinea Pigs; Ileum; In Vitro Techniques; Lactones; Male; Parasympatholytics; Plant Extracts; Plant Leaves; Sesquiterpenes | 2005 |
Sesquiterpene lactones are potent and irreversible inhibitors of the antibacterial target enzyme MurA.
Topics: Alkyl and Aryl Transferases; Enzyme Inhibitors; Escherichia coli; Lactones; Peptidoglycan; Pseudomonas aeruginosa; Sesquiterpenes; Structure-Activity Relationship | 2006 |
The chemopreventive effects of Saussurea salicifolia through induction of apoptosis and phase II detoxification enzyme.
Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Cell Line, Tumor; Cell Proliferation; Chromatin; DNA, Neoplasm; Enzyme Induction; Ethanol; Flow Cytometry; Furans; Humans; Lactones; Lignans; Metabolic Detoxication, Phase II; NAD(P)H Dehydrogenase (Quinone); Neoplasms; Plant Extracts; Saussurea; Sesquiterpenes; Solvents; Tetrazolium Salts; Thiazoles | 2007 |
Supercritical fluid extraction of cynaropicrin and 20-hydroxyecdysone from Leuzea carthamoides DC.
Topics: Chemistry Techniques, Analytical; Chromatography, Supercritical Fluid; Ecdysterone; Ethanol; Lactones; Leuzea; Models, Chemical; Plant Extracts; Plant Leaves; Plant Roots; Pressure; Sesquiterpenes; Solvents; Temperature | 2008 |
Quantification of cynaropicrin in artichoke leaf extracts by ¹H NMR spectroscopy.
Topics: Cynara scolymus; Lactones; Magnetic Resonance Spectroscopy; Plant Extracts; Plant Leaves; Quality Control; Reference Standards; Reproducibility of Results; Sensitivity and Specificity; Sesquiterpenes; Solid Phase Extraction | 2011 |
Cynaropicrin: the first plant natural product with in vivo activity against Trypanosoma brucei.
Topics: Animals; Cell Line; Centaurea; Disease Models, Animal; Female; Humans; Inhibitory Concentration 50; Injections, Intraperitoneal; Lactones; Mice; Molecular Structure; Parasitemia; Parasitic Sensitivity Tests; Plant Components, Aerial; Plant Extracts; Rats; Sesquiterpenes; Trypanocidal Agents; Trypanosoma brucei gambiense; Trypanosoma brucei rhodesiense; Trypanosomiasis, African | 2012 |
Genetic mapping and characterization of the globe artichoke (+)-germacrene A synthase gene, encoding the first dedicated enzyme for biosynthesis of the bitter sesquiterpene lactone cynaropicrin.
Topics: Alkyl and Aryl Transferases; Biosynthetic Pathways; Chromatography, Liquid; Chromosome Mapping; Cynara scolymus; DNA, Complementary; Escherichia coli; Gas Chromatography-Mass Spectrometry; Gene Expression Profiling; Gene Expression Regulation, Plant; Genes, Plant; Genetic Linkage; Lactones; Molecular Sequence Data; Organ Specificity; Phenols; Phylogeny; Plant Proteins; Polymorphism, Single Nucleotide; Sesquiterpenes; Taste | 2012 |
Cynaropicrin from Cynara scolymus L. suppresses photoaging of skin by inhibiting the transcription activity of nuclear factor-kappa B.
Topics: Animals; Cells, Cultured; Cynara scolymus; Disease Models, Animal; Lactones; Mice; NF-kappa B; Plant Extracts; Sesquiterpenes; Skin Aging; Transcription, Genetic | 2013 |
Antiprotozoal screening of 60 South African plants, and the identification of the antitrypanosomal germacranolides schkuhrin I and II.
Topics: Antimalarials; Antiprotozoal Agents; Asteraceae; Humans; Inhibitory Concentration 50; Lactones; Leishmania donovani; Plant Extracts; Plasmodium falciparum; Sesquiterpenes; Sesquiterpenes, Germacrane; South Africa; Trypanocidal Agents; Trypanosoma brucei rhodesiense; Trypanosoma cruzi; Vernonia | 2013 |
Activities of psilostachyin A and cynaropicrin against Trypanosoma cruzi in vitro and in vivo.
Topics: Animals; Autophagy; Cell Membrane; Chagas Disease; Lactones; Liver; Male; Mice; Microscopy, Electron, Transmission; Nitroimidazoles; Parasitic Sensitivity Tests; Sesquiterpenes; Survival Analysis; Treatment Failure; Trypanocidal Agents; Trypanosoma cruzi; Vacuoles | 2013 |
Cynaropicrin targets the trypanothione redox system in Trypanosoma brucei.
Topics: Amide Synthases; Enzyme Activation; Humans; Lactones; NADH, NADPH Oxidoreductases; Ornithine Decarboxylase; Ornithine Decarboxylase Inhibitors; Oxidation-Reduction; Protozoan Proteins; Sesquiterpenes; Sulfhydryl Compounds; Trypanosoma brucei brucei; Trypanosomiasis, African | 2013 |
Mild oxidative stress induces S-glutathionylation of STAT3 and enhances chemosensitivity of tumoural cells to chemotherapeutic drugs.
Topics: Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cell Proliferation; Cell Survival; Cisplatin; Cytotoxins; Docetaxel; Drug Resistance, Neoplasm; Drug Synergism; Glutathione; Humans; Inhibitor of Apoptosis Proteins; Lactones; Oxidative Stress; Phosphorylation; Poly(ADP-ribose) Polymerases; Protein Processing, Post-Translational; Proto-Oncogene Proteins c-bcl-2; Reactive Oxygen Species; Sesquiterpenes; Signal Transduction; STAT3 Transcription Factor; Survivin; Taxoids | 2013 |
Antitrypanosomal structure-activity-relationship study of synthetic cynaropicrin derivatives.
Topics: Inhibitory Concentration 50; Lactones; Molecular Structure; Sesquiterpenes; Structure-Activity Relationship; Trypanocidal Agents; Trypanosoma brucei brucei | 2014 |
Cynaropicrin attenuates UVB-induced oxidative stress via the AhR-Nrf2-Nqo1 pathway.
Topics: Active Transport, Cell Nucleus; Antioxidants; Basic Helix-Loop-Helix Transcription Factors; Cells, Cultured; Cytoprotection; Dose-Response Relationship, Drug; Humans; Inflammation Mediators; Interleukin-6; Keratinocytes; Lactones; NAD(P)H Dehydrogenase (Quinone); NF-E2-Related Factor 2; Oxidative Stress; Receptors, Aryl Hydrocarbon; RNA Interference; RNA, Messenger; Sesquiterpenes; Signal Transduction; Transfection; Tumor Necrosis Factor-alpha; Ultraviolet Rays; Up-Regulation | 2015 |
[Effect of Cynaropicrin on 2,3,4,7,8-Pentachlorodibenzofuran-induced Wasting Syndrome and Oxidative Stress].
Topics: Animals; Benzofurans; Dose-Response Relationship, Drug; Lactones; Mice; Mice, Inbred C57BL; Oxidative Stress; Sesquiterpenes; Wasting Syndrome | 2015 |
Accumulation of cynaropicrin in globe artichoke and localization of enzymes involved in its biosynthesis.
Topics: Cynara scolymus; Gene Expression Regulation, Plant; Lactones; Microscopy, Confocal; Microscopy, Fluorescence; Plant Proteins; Sesquiterpenes; Tissue Distribution | 2015 |
Sesquiterpene Lactones from Cynara cornigera: Acetyl Cholinesterase Inhibition and In Silico Ligand Docking.
Topics: Africa; Antioxidants; Chelating Agents; Cholinesterase Inhibitors; Crystallography, X-Ray; Cynara; Free Radical Scavengers; Lactones; Molecular Structure; Plant Extracts; Sesquiterpenes | 2016 |
Synthesis of cynaropicrin-d(4).
Topics: Deuterium; Lactones; Molecular Structure; Sesquiterpenes; Trypanocidal Agents | 2015 |
Pan-genotypic Hepatitis C Virus Inhibition by Natural Products Derived from the Wild Egyptian Artichoke.
Topics: Antiviral Agents; Biological Products; Cynara; Hepacivirus; Lactones; Plant Extracts; Plant Leaves; Sesquiterpenes; Virus Internalization | 2016 |
Cynaropicrin is dual regulator for both degradation factors and synthesis factors in the cartilage metabolism.
Topics: Aggrecans; Basic Helix-Loop-Helix Transcription Factors; Cartilage; Cell Line; Humans; Hydrolysis; Lactones; Matrix Metalloproteinase 13; NF-kappa B; Sesquiterpenes; SOX9 Transcription Factor; Tumor Necrosis Factor-alpha | 2016 |
The Joint Action of Sesquiterpene Lactones from Leaves as an Explanation for the Activity of Cynara cardunculus.
Topics: Cotyledon; Cynara; Lactones; Molecular Structure; Plant Extracts; Plant Leaves; Sesquiterpenes; Triticum | 2016 |
Investigation of the Anti-Leishmania (Leishmania) infantum Activity of Some Natural Sesquiterpene Lactones.
Topics: Animals; Antiprotozoal Agents; Bridged-Ring Compounds; Cells, Cultured; Drug Evaluation, Preclinical; Furans; Inhibitory Concentration 50; Lactones; Leishmania infantum; Leishmaniasis, Visceral; Macrophages, Peritoneal; Mice, Inbred BALB C; Nitric Oxide; Sesquiterpenes; Sesquiterpenes, Germacrane; Sesquiterpenes, Guaiane; Sesterterpenes | 2017 |
Antiproliferative activity against leukemia cells of sesquiterpene lactones from the Turkish endemic plant Centaurea drabifolia subsp. detonsa.
Topics: Antineoplastic Agents, Phytogenic; Cell Line, Tumor; Centaurea; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Humans; Lactones; Leukemia; Molecular Structure; Plant Components, Aerial; Plant Extracts; Sesquiterpenes; Sesquiterpenes, Guaiane; Structure-Activity Relationship; Turkey | 2017 |
Qualitative HPLC-DAD/ESI-TOF-MS Analysis, Cytotoxic, and Apoptotic Effects of Croatian Endemic Centaurea ragusina L. Aqueous Extracts.
Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Cell Line, Tumor; Centaurea; Chromatography, High Pressure Liquid; Glioblastoma; Humans; Lactones; Plant Extracts; Sesquiterpenes; Spectrometry, Mass, Electrospray Ionization; Urinary Bladder Neoplasms | 2017 |
Screening of several biological activities induced by different sesquiterpene lactones isolated from Centaurea behen L. and Rhaponticum repens (L.) Hidalgo.
Topics: Angiogenesis Inhibitors; Animals; Anti-Bacterial Agents; Antifungal Agents; Antineoplastic Agents, Phytogenic; Cell Line, Tumor; Centaurea; Drug Evaluation, Preclinical; Flavones; Human Umbilical Vein Endothelial Cells; Humans; Lactones; Leuzea; Mice; Plant Extracts; Sesquiterpenes | 2018 |
Deep Eutectic Solvents as Efficient Media for the Extraction and Recovery of Cynaropicrin from Cynara cardunculus L. Leaves.
Topics: Biomass; Cynara; Lactones; Molecular Structure; Plant Extracts; Plant Leaves; Sesquiterpenes; Solvents | 2017 |
Haplotype analysis of the germacrene A synthase gene and association with cynaropicrin content and biological activities in Cynara cardunculus.
Topics: Alkyl and Aryl Transferases; Bacteria; Cell Line, Tumor; Cell Survival; Cynara; Gene Frequency; Haplotypes; Humans; Lactones; Microbial Sensitivity Tests; Phylogeny; Plant Extracts; Plant Leaves; Plant Proteins; Polymorphism, Single Nucleotide; Sesquiterpenes; Triterpenes | 2018 |
Potential bioaccessibility and functionality of polyphenols and cynaropicrin from breads enriched with artichoke stem.
Topics: Antioxidants; Biological Availability; Bread; Caffeic Acids; Cynara scolymus; Digestion; Food, Fortified; Humans; Lactones; Plant Stems; Polyphenols; Sesquiterpenes | 2018 |
Dual role of YM1+ M2 macrophages in allergic lung inflammation.
Topics: Animals; Asthma; Cell Polarity; Female; Lactones; Macrophages; Mice, Inbred BALB C; Pneumonia; Respiratory Hypersensitivity; Sesquiterpenes | 2018 |
Cynaropicrin from Cynara scolymus L. suppresses Porphyromonas gingivalis LPS-induced production of inflammatory cytokines in human gingival fibroblasts and RANKL-induced osteoclast differentiation in RAW264.7 cells.
Topics: Animals; Cell Differentiation; Cells, Cultured; Cynara scolymus; Cytokines; Fibroblasts; Gingiva; Humans; Lactones; Lipopolysaccharides; Mice; Osteoclasts; Phosphorylation; Porphyromonas gingivalis; RANK Ligand; RAW 264.7 Cells; Sesquiterpenes; Transcription Factor RelA; Transcriptional Activation | 2019 |
Antiproliferative Effects of Cynaropicrin on Anaplastic Thyroid Cancer Cells.
Topics: Antineoplastic Agents, Phytogenic; Antioxidants; Cell Cycle Checkpoints; Cell Line, Tumor; Cell Survival; Humans; Lactones; Lipid Peroxidation; Malondialdehyde; NF-kappa B; Phosphorylation; Reactive Oxygen Species; Sesquiterpenes; STAT3 Transcription Factor; Thyroid Carcinoma, Anaplastic; Thyroid Neoplasms | 2019 |
Promotion of HeLa cells apoptosis by cynaropicrin involving inhibition of thioredoxin reductase and induction of oxidative stress.
Topics: Apoptosis; Cell Proliferation; Cynara scolymus; Gene Expression Regulation, Neoplastic; HeLa Cells; Humans; Lactones; Neoplasms; Oxidation-Reduction; Oxidative Stress; Reactive Oxygen Species; Sesquiterpenes; Thioredoxin-Disulfide Reductase | 2019 |
Cynaropicrin and inhibition of NF-κB activation: A structure activity relationship study.
Topics: Cytotoxins; Humans; Lactones; NF-kappa B; Sesquiterpenes; Structure-Activity Relationship | 2019 |
Development of bioactive films based on chitosan and Cynara cardunculus leaves extracts for wound dressings.
Topics: Bandages; Cell Line; Cell Survival; Chitosan; Cynara; Fibroblasts; Humans; Lactones; Microscopy, Electron, Scanning; Plant Extracts; Plant Leaves; Sesquiterpenes; Skin; Wound Healing | 2020 |
Inhibitory effects of cynaropicrin on human melanoma progression by targeting MAPK, NF-κB, and Nrf-2 signaling pathways in vitro.
Topics: Apoptosis; Cell Proliferation; Disease Progression; Humans; Lactones; Melanoma; Mitogen-Activated Protein Kinase Kinases; NF-kappa B; Sesquiterpenes; Signal Transduction | 2021 |
Inhibitory effects of cynaropicrin and related sesquiterpene lactones from leaves of artichoke (Cynara scolymus L.) on induction of iNOS in RAW264.7 cells and its high-affinity proteins.
Topics: Animals; Cynara scolymus; Lactones; Mice; Nitric Oxide Synthase Type II; Plant Leaves; RAW 264.7 Cells; Sesquiterpenes | 2021 |
Renal Tissue Damage Induced by Acute Kidney Injury in Sepsis Rat Model Is Inhibited by Cynaropicrin via IL-1β and TNF-α Down-Regulation.
Topics: Acute Kidney Injury; Animals; Disease Models, Animal; Down-Regulation; Interleukin-1beta; Lactones; Proto-Oncogene Proteins c-bcl-2; Rats; Sepsis; Sesquiterpenes; Tumor Necrosis Factor-alpha | 2021 |
Cynaropicrin Induces Cell Cycle Arrest and Apoptosis by Inhibiting PKM2 to Cause DNA Damage and Mitochondrial Fission in A549 Cells.
Topics: A549 Cells; Apoptosis; Cell Cycle Checkpoints; DNA Damage; Humans; Lactones; Mitochondrial Dynamics; Pyruvate Kinase; Sesquiterpenes | 2021 |
Cynaropicrin Averts the Oxidative Stress and Neuroinflammation in Ischemic/Reperfusion Injury Through the Modulation of NF-kB.
Topics: Animals; Antioxidants; bcl-2-Associated X Protein; Brain Ischemia; Caspase 3; Infarction, Middle Cerebral Artery; Inflammation Mediators; Interleukin-10; Lactones; Neuroinflammatory Diseases; NF-kappa B; Nitrates; Oxidative Stress; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Sesquiterpenes; Stroke | 2023 |