Page last updated: 2024-08-17

cycloserine and n-methylaspartate

cycloserine has been researched along with n-methylaspartate in 36 studies

Research

Studies (36)

TimeframeStudies, this research(%)All Research%
pre-19901 (2.78)18.7374
1990's14 (38.89)18.2507
2000's9 (25.00)29.6817
2010's7 (19.44)24.3611
2020's5 (13.89)2.80

Authors

AuthorsStudies
Bellows, DS; Clarke, ID; Diamandis, P; Dirks, PB; Graham, J; Jamieson, LG; Ling, EK; Sacher, AG; Tyers, M; Ward, RJ; Wildenhain, J1
Ascher, P; Henderson, G; Johnson, JW1
Herberg, LJ; Rose, IC1
Cler, J; Emmett, MR; Iyengar, S; Mick, S; Rao, TS; Wood, PL1
Chau, A; Khanna, JM; Morato, GS; Shah, G1
Fonnum, F; Myhrer, T; Oksengård, AR; Paulsen, RE; Wangen, K1
Carlsson, A; Carlsson, ML; Engberg, G1
Dall'Olio, R; Gandolfi, O1
Dall'Olio, R; Gandolfi, O; Rimondini, R1
Müller, WE; Scheuer, K; Stoll, S1
Fedele, E; Pittaluga, A; Raiteri, M; Risiglione, C1
Davis, RE; Deutsch, SI; Fay-McCarthy, M; Kendrick, K; Rosse, RB1
Hamm, RJ; Temple, MD1
Ohno, M; Watanabe, S1
Blankenstein, MA; Gispen-de Wied, C; Kahn, RS; Lipsch, C; van Berckel, BN; van Ree, JM; Wynne, HJ1
Monogham, DT; Rosenquist, TH; Schneider, AM1
Benveniste, M; Shavit, S; Sheinin, A1
Hozumi, S; Kisara, K; Murata, A; Nakagawasai, O; Niijima, F; Tadano, T; Tan-No, K; Yamadera, F1
Cranney, J; Ledgerwood, L; Richardson, R1
Dadds, MR; Guastella, AJ; Lovibond, PF; Mitchell, P; Richardson, R1
Apkarian, AV; Berra, HH; Centeno, MV; Lavarello, S; Millecamps, M; Rudick, CN; Tkatch, T1
Rothwell, JC; Swayne, OB; Teo, JT1
Büchel, C; De Martino, B; Dolan, RJ; Holt, B; Kalisch, R; Klöppel, S; Petrovic, P1
Dubrovina, NI; Zinovyev, DR; Zinovyeva, DV1
Gean, PW; Lin, HC; Mao, SC; Su, CL1
Ananth, M; Lui, W; Michaelides, M; Puca, Z; Subrize, M; Thanos, PK; Volkow, ND; Wang, GJ1
Dubrovina, NI; Zinov'eva, DV1
Lenze, EJ; Rodebaugh, TL1
Altemus, M; Anderson, P; Andersson, E; Cukor, J; Davis, M; de Kleine, RA; Difede, J; Dunlop, BW; Farrell, LJ; Fernández de la Cruz, L; Finck, C; Frumento, P; Geffken, GR; Geller, D; Gerardi, M; Golfels, F; Goodman, WK; Guastella, AJ; Gutner, C; Hendriks, GJ; Heyman, I; Hofmann, SG; Jovanovic, T; Kushner, MG; Lee, FS; Lenze, EJ; Levinson, CA; Lewin, AB; Mataix-Cols, D; McConnell, H; McNamara, JP; Monzani, B; Murphy, TK; Norrholm, S; Otto, MW; Pérez-Vigil, A; Plag, J; Pollack, MH; Ressler, KJ; Rodebaugh, TL; Rosenfield, D; Rothbaum, BO; Rück, C; Scheeringa, MS; Siewert-Siegmund, A; Smits, JAJ; Storch, EA; Ströhle, A; Tart, CD; Thuras, P; Tolin, DF; van Minnen, A; Waters, AM; Weems, CF; Wilhelm, S; Wyka, K1
Cheng, B; Huang, Y; Li, D; Liu, G; Shen, W; Su, J; Zhang, YX; Zhou, WX1
Carpenter, A; Leyfer, O; Pincus, D1
Kozyrev, SA; Nikitin, VP; Solntseva, SV1
Inslicht, SS; Lipshitz, SL; Marmar, CR; Metzler, TJ; Milad, MR; Neylan, TC; Niles, AN; Orr, SP; Otte, C1
Bastlund, JF; Christensen, SR; De Meyer, K; Gabay, A; Gijsen, S; Herrik, KF; Mehta, MA; Nottage, JF1
Burket, JA; Deutsch, SI1
Cole, J; McGirr, A; Sohn, MN; Wrightson, JG1

Reviews

4 review(s) available for cycloserine and n-methylaspartate

ArticleYear
Glutamatergic treatment strategies for age-related memory disorders.
    Life sciences, 1994, Volume: 55, Issue:25-26

    Topics: Acetamides; Aging; Animals; Cognition; Cycloserine; Glutamic Acid; Humans; Memory Disorders; N-Methylaspartate; Nootropic Agents; Receptors, N-Methyl-D-Aspartate

1994
Lessons learned from D-cycloserine: the promise and limits of drug facilitation of exposure therapy.
    The Journal of clinical psychiatry, 2013, Volume: 74, Issue:4

    Topics: Animals; Antimetabolites; Anxiety Disorders; Combined Modality Therapy; Cycloserine; Humans; Implosive Therapy; N-Methylaspartate; Treatment Outcome

2013
D-Cycloserine Augmentation of Exposure-Based Cognitive Behavior Therapy for Anxiety, Obsessive-Compulsive, and Posttraumatic Stress Disorders: A Systematic Review and Meta-analysis of Individual Participant Data.
    JAMA psychiatry, 2017, 05-01, Volume: 74, Issue:5

    Topics: Antidepressive Agents; Anxiety Disorders; Combined Modality Therapy; Cycloserine; Drug Synergism; Excitatory Amino Acid Agonists; Humans; Implosive Therapy; N-Methylaspartate; Obsessive-Compulsive Disorder; Outcome Assessment, Health Care; Stress Disorders, Post-Traumatic

2017
From Mouse to Man: N-Methyl-d-Aspartic Acid Receptor Activation as a Promising Pharmacotherapeutic Strategy for Autism Spectrum Disorders.
    The Medical clinics of North America, 2023, Volume: 107, Issue:1

    Topics: Animals; Autism Spectrum Disorder; Cycloserine; Dizocilpine Maleate; Humans; Mice; Mice, Inbred BALB C; N-Methylaspartate; Randomized Controlled Trials as Topic; Receptors, N-Methyl-D-Aspartate; Social Behavior

2023

Trials

7 trial(s) available for cycloserine and n-methylaspartate

ArticleYear
D-cycloserine adjuvant therapy to molindone in the treatment of schizophrenia.
    Clinical neuropharmacology, 1996, Volume: 19, Issue:5

    Topics: Administration, Oral; Adult; Aged; Antipsychotic Agents; Chemotherapy, Adjuvant; Cycloserine; Dose-Response Relationship, Drug; Drug Therapy, Combination; Humans; Middle Aged; Molindone; N-Methylaspartate; Psychiatric Status Rating Scales; Schizophrenia

1996
The partial NMDA agonist D-cycloserine stimulates LH secretion in healthy volunteers.
    Psychopharmacology, 1998, Volume: 138, Issue:2

    Topics: Adult; Affect; Antipsychotic Agents; Behavior; Blood Pressure; Body Temperature; Brief Psychiatric Rating Scale; Cross-Over Studies; Cycloserine; Dopamine; Double-Blind Method; Heart Rate; Homovanillic Acid; Humans; Hydrocortisone; Luteinizing Hormone; Male; N-Methylaspartate; Neurosecretory Systems; Receptors, N-Methyl-D-Aspartate; Schizophrenia

1998
A randomized controlled trial of the effect of D-cycloserine on exposure therapy for spider fear.
    Journal of psychiatric research, 2007, Volume: 41, Issue:6

    Topics: Adolescent; Adult; Animals; Cognitive Behavioral Therapy; Combined Modality Therapy; Cycloserine; Drug Administration Schedule; Extinction, Psychological; Fear; Female; Humans; Male; Middle Aged; N-Methylaspartate; Phobic Disorders; Photic Stimulation; Spiders

2007
Further evidence for NMDA-dependence of the after-effects of human theta burst stimulation.
    Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology, 2007, Volume: 118, Issue:7

    Topics: Adult; Cerebral Cortex; Cycloserine; Double-Blind Method; Evoked Potentials, Motor; Excitatory Amino Acid Antagonists; Female; Humans; Male; N-Methylaspartate; Receptors, N-Methyl-D-Aspartate; Theta Rhythm; Transcranial Magnetic Stimulation

2007
N-methyl-D-aspartate Partial Agonist Enhanced Intensive Cognitive-Behavioral Therapy of Panic Disorder in Adolescents.
    Child psychiatry and human development, 2019, Volume: 50, Issue:2

    Topics: Adolescent; Adult; Cognitive Behavioral Therapy; Combined Modality Therapy; Cycloserine; Double-Blind Method; Fear; Female; Humans; Implosive Therapy; Male; N-Methylaspartate; Panic Disorder; Parents; Psychotropic Drugs; Treatment Outcome

2019
Randomized controlled experimental study of hydrocortisone and D-cycloserine effects on fear extinction in PTSD.
    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2022, Volume: 47, Issue:11

    Topics: Cycloserine; Double-Blind Method; Extinction, Psychological; Fear; Glucocorticoids; Humans; Hydrocortisone; N-Methylaspartate; Receptors, N-Methyl-D-Aspartate; Stress Disorders, Post-Traumatic

2022
The effects of D-Cycloserine on corticospinal excitability after repeated spaced intermittent theta-burst transcranial magnetic stimulation: A randomized controlled trial in healthy individuals.
    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2023, Volume: 48, Issue:8

    Topics: Adult; Cycloserine; Evoked Potentials, Motor; Humans; Motor Cortex; N-Methylaspartate; Neuronal Plasticity; Theta Rhythm; Transcranial Magnetic Stimulation

2023

Other Studies

25 other study(ies) available for cycloserine and n-methylaspartate

ArticleYear
Chemical genetics reveals a complex functional ground state of neural stem cells.
    Nature chemical biology, 2007, Volume: 3, Issue:5

    Topics: Animals; Cell Survival; Cells, Cultured; Mice; Molecular Structure; Neoplasms; Neurons; Pharmaceutical Preparations; Sensitivity and Specificity; Stem Cells

2007
Competitive antagonists and partial agonists at the glycine modulatory site of the mouse N-methyl-D-aspartate receptor.
    The Journal of physiology, 1990, Volume: 430

    Topics: Action Potentials; Animals; Brain; Cells, Cultured; Cerebral Cortex; Cycloserine; Diencephalon; Glycine; Ion Channels; Kynurenic Acid; Mice; N-Methylaspartate; Neurons; Pyrrolidinones; Receptors, N-Methyl-D-Aspartate

1990
Effects of D-cycloserine and cycloleucine, ligands for the NMDA-associated strychnine-insensitive glycine site, on brain-stimulation reward and spontaneous locomotion.
    Pharmacology, biochemistry, and behavior, 1990, Volume: 36, Issue:4

    Topics: Animals; Brain; Cycloleucine; Cycloserine; Dose-Response Relationship, Drug; Ligands; Male; Motor Activity; N-Methylaspartate; Rats; Receptors, Glycine; Receptors, Neurotransmitter; Reward; Self Stimulation; Strychnine

1990
In vivo modulation of the N-methyl-D-aspartate receptor complex by D-serine: potentiation of ongoing neuronal activity as evidenced by increased cerebellar cyclic GMP.
    Journal of neurochemistry, 1989, Volume: 53, Issue:3

    Topics: Animals; Aspartic Acid; Cerebellum; Cyclic GMP; Cycloserine; Dibenzocycloheptenes; Dizocilpine Maleate; Male; Mice; N-Methylaspartate; Neurons; Piperazines; Pyrrolidinones; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Serine

1989
Influence of nitric oxide synthase inhibition on the development of rapid tolerance to ethanol.
    Brain research bulletin, 1995, Volume: 37, Issue:6

    Topics: Amino Acid Oxidoreductases; Animals; Arginine; Brain; Cycloserine; Drug Tolerance; Ethanol; Male; N-Methylaspartate; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Nitroarginine; Postural Balance; Rats; Rats, Sprague-Dawley

1995
Role of glutamate and glutamate receptors in memory function and Alzheimer's disease.
    Annals of the New York Academy of Sciences, 1995, May-10, Volume: 757

    Topics: Adult; Aged; Alzheimer Disease; Animals; Cognition; Cycloserine; Discrimination Learning; Entorhinal Cortex; Female; Glutamic Acid; Humans; Male; Memory; N-Methylaspartate; Rats; Receptors, Glutamate; Temporal Lobe

1995
Effects of D-cycloserine and (+)-HA-966 on the locomotor stimulation induced by NMDA antagonists and clonidine in monoamine-depleted mice.
    Journal of neural transmission. General section, 1994, Volume: 95, Issue:3

    Topics: Allosteric Site; Animals; Biogenic Monoamines; Clonidine; Cycloserine; Dose-Response Relationship, Drug; Mice; Motor Activity; N-Methylaspartate; Pyrrolidinones; Receptors, Adrenergic, alpha-2; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate

1994
The NMDA positive modulator D-cycloserine potentiates the neuroleptic activity of D1 and D2 dopamine receptor blockers in the rat.
    Psychopharmacology, 1993, Volume: 110, Issue:1-2

    Topics: Animals; Antipsychotic Agents; Apomorphine; Benzamides; Benzazepines; Cycloserine; Dizocilpine Maleate; Dopamine Antagonists; Dopamine D2 Receptor Antagonists; Dose-Response Relationship, Drug; Male; Motor Activity; N-Methylaspartate; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D1; Stereotyped Behavior

1993
The NMDA positive modulator D-cycloserine inhibits dopamine-mediated behaviors in the rat.
    Neuropharmacology, 1994, Volume: 33, Issue:1

    Topics: Animals; Apomorphine; Behavior, Animal; Benzazepines; Cycloserine; Dopamine; Dopamine Agents; Dopamine Antagonists; Dopamine D2 Receptor Antagonists; Ergolines; Grooming; Male; Methamphetamine; Motor Activity; N-Methylaspartate; Quinpirole; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D1; Receptors, Dopamine D2; Stereotyped Behavior; Sulpiride

1994
Age-related decrease of the NMDA receptor-mediated noradrenaline release in rat hippocampus and partial restoration by D-cycloserine.
    European journal of pharmacology, 1993, Jan-26, Volume: 231, Issue:1

    Topics: Aging; Animals; Cycloserine; Glycine; Hippocampus; In Vitro Techniques; Male; N-Methylaspartate; Norepinephrine; Rats; Rats, Inbred WKY; Receptors, N-Methyl-D-Aspartate; Stereoisomerism; Synaptosomes

1993
Chronic, post-injury administration of D-cycloserine, an NMDA partial agonist, enhances cognitive performance following experimental brain injury.
    Brain research, 1996, Nov-25, Volume: 741, Issue:1-2

    Topics: Animals; Antimetabolites; Brain Injuries; Cognition; Cycloserine; Male; Maze Learning; N-Methylaspartate; Postural Balance; Rats; Rats, Sprague-Dawley

1996
Enhanced N-methyl-D-aspartate function reverses working memory failure induced by blockade of group I metabotropic glutamate receptors in the rat hippocampus.
    Neuroscience letters, 1998, Jan-02, Volume: 240, Issue:1

    Topics: Animals; Behavior, Animal; Cycloserine; Dose-Response Relationship, Drug; Hippocampus; Indans; Male; Memory; Microinjections; N-Methylaspartate; Rats; Rats, Wistar; Receptors, Metabotropic Glutamate

1998
N-methyl-D-aspartate receptor agonists modulate homocysteine-induced developmental abnormalities.
    FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 1999, Volume: 13, Issue:12

    Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Chick Embryo; Cycloserine; Excitatory Amino Acid Agonists; Glutamic Acid; Glycine; Homocysteine; N-Methylaspartate; Nervous System; Nervous System Malformations; Receptors, N-Methyl-D-Aspartate; Teratogens

1999
Subunit specificity and mechanism of action of NMDA partial agonist D-cycloserine.
    Neuropharmacology, 2001, Volume: 41, Issue:2

    Topics: Animals; Antimetabolites; Cycloserine; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Female; Hydrogen-Ion Concentration; N-Methylaspartate; Oocytes; Receptors, N-Methyl-D-Aspartate; Xenopus

2001
Effects of NMDA receptor-related agonists on learning and memory impairment in olfactory bulbectomized mice.
    Methods and findings in experimental and clinical pharmacology, 2004, Volume: 26, Issue:2

    Topics: 2-Amino-5-phosphonovalerate; Animals; Avoidance Learning; Cycloserine; Disease Models, Animal; Dizocilpine Maleate; Drug Therapy, Combination; Injections, Intraventricular; Male; Memory Disorders; Mice; N-Methylaspartate; Olfactory Bulb; Piperidines; Receptors, N-Methyl-D-Aspartate; Spermidine; Time Factors

2004
D-cycloserine facilitates extinction of learned fear: effects on reacquisition and generalized extinction.
    Biological psychiatry, 2005, Apr-15, Volume: 57, Issue:8

    Topics: Animals; Antimetabolites; Avoidance Learning; Calorimetry, Differential Scanning; Conditioning, Psychological; Cycloserine; Excitatory Amino Acid Agonists; Extinction, Psychological; Fear; Learning; Male; N-Methylaspartate; Rats; Rats, Sprague-Dawley

2005
D-cycloserine reduces neuropathic pain behavior through limbic NMDA-mediated circuitry.
    Pain, 2007, Volume: 132, Issue:1-2

    Topics: Analgesics; Animals; Behavior, Animal; Cycloserine; Dose-Response Relationship, Drug; Hyperalgesia; Limbic System; N-Methylaspartate; Neuralgia; Pain Measurement; Rats; Rats, Sprague-Dawley; Treatment Outcome

2007
The NMDA agonist D-cycloserine facilitates fear memory consolidation in humans.
    Cerebral cortex (New York, N.Y. : 1991), 2009, Volume: 19, Issue:1

    Topics: Adaptation, Physiological; Adult; Brain; Conditioning, Psychological; Cycloserine; Fear; Female; Humans; Mental Recall; N-Methylaspartate; Receptors, N-Methyl-D-Aspartate

2009
N-methyl-D-aspartate receptors and amnesia in mice with depression-like state.
    Bulletin of experimental biology and medicine, 2007, Volume: 144, Issue:5

    Topics: Amnesia; Analysis of Variance; Animals; Avoidance Learning; Behavior, Animal; Cycloserine; Depression; Dizocilpine Maleate; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Kynurenic Acid; Male; Mice; Mice, Inbred C57BL; N-Methylaspartate; Receptors, Amino Acid

2007
Alterations of excitatory transmission in the lateral amygdala during expression and extinction of fear memory.
    The international journal of neuropsychopharmacology, 2010, Volume: 13, Issue:3

    Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Acoustic Stimulation; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Amygdala; Animals; Behavior, Animal; Cycloserine; Electric Stimulation; Endocytosis; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Extinction, Psychological; Fear; In Vitro Techniques; Male; Membrane Potentials; Memory; N-Methylaspartate; Patch-Clamp Techniques; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Synaptic Transmission

2010
D-cycloserine facilitates extinction of cocaine self-administration in C57 mice.
    Synapse (New York, N.Y.), 2011, Volume: 65, Issue:10

    Topics: Animals; Behavior, Animal; Cocaine; Cocaine-Related Disorders; Conditioning, Operant; Cues; Cycloserine; Dopamine Uptake Inhibitors; Extinction, Psychological; Injections, Intraperitoneal; Male; Mice; Mice, Inbred C57BL; N-Methylaspartate; Self Administration; Stereoisomerism

2011
[Interaction of N-methyl-D-aspartate and Dopamine D1 receptors in modulation of passive avoidance extinction at mice with depressive-like state].
    Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova, 2011, Volume: 97, Issue:7

    Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Avoidance Learning; Cycloserine; Depression; Depressive Disorder; Dopamine; Dopamine Agonists; Extinction, Psychological; Injections, Intraperitoneal; Male; Memory; Mice; Mice, Inbred C57BL; Models, Animal; N-Methylaspartate; Receptor Cross-Talk; Receptors, Dopamine D1; Receptors, N-Methyl-D-Aspartate

2011
Modulating the Balance of Synaptic and Extrasynaptic NMDA Receptors Shows Positive Effects against Amyloid-β-Induced Neurotoxicity.
    Journal of Alzheimer's disease : JAD, 2017, Volume: 57, Issue:3

    Topics: Amyloid beta-Peptides; Animals; Antimetabolites; Cycloserine; Disease Models, Animal; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Hippocampus; Locomotion; Male; Maze Learning; N-Methylaspartate; Nesting Behavior; Neurotoxicity Syndromes; Peptide Fragments; Piperidines; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Recognition, Psychology; Signal Transduction; Synapses

2017
A Study of the Participation of NMDA Glutamate Receptors in the Mechanisms of Specific Anterograde Amnesia Reversion.
    Bulletin of experimental biology and medicine, 2020, Volume: 170, Issue:2

    Topics: Amnesia; Amnesia, Anterograde; Animals; Avoidance Learning; Conditioning, Classical; Cycloserine; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Glutamic Acid; Glycine; Helix, Snails; Memory; Memory, Long-Term; Memory, Short-Term; Models, Animal; N-Methylaspartate; Neuronal Plasticity; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Reproducibility of Results; Synapses

2020
The effect of ketamine and D-cycloserine on the high frequency resting EEG spectrum in humans.
    Psychopharmacology, 2023, Volume: 240, Issue:1

    Topics: Cross-Over Studies; Cycloserine; Double-Blind Method; Electroencephalography; Humans; Ketamine; Male; N-Methylaspartate; Receptors, N-Methyl-D-Aspartate

2023
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