Page last updated: 2024-09-05

cyclophellitol and cyclohexanol

cyclophellitol has been researched along with cyclohexanol in 42 studies

Compound Research Comparison

Studies (cyclophellitol)	Trials (cyclophellitol)	Recent Studies (post-2010) (cyclophellitol)	Studies (cyclohexanol)	Trials (cyclohexanol)	Recent Studies (post-2010) (cyclohexanol)
44	0	24	4,548	691	1,355

Research

Studies (42)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	11 (26.19)	18.2507
2000's	6 (14.29)	29.6817
2010's	18 (42.86)	24.3611
2020's	7 (16.67)	2.80

Authors

Authors	Studies
Atsumi, S; Iinuma, H; Nosaka, C; Umezawa, K	3
Nakata, M; Niwata, Y; Tatsuta, K; Toshima, K; Umezawa, K	2
Umezawa, K; Withers, SG	1
Atsumi, S; Iinuma, H; Iitaka, Y; Naganawa, H; Nakamura, H; Takeuchi, T; Umezawa, K	1
Fung, PH; Shing, TK; Tai, VW; Wong, YS	1
Chong, C; Nakata, M; Niwata, Y; Tatsuta, K; Toshima, K	1
Atsumi, S; Iinuma, H; Nosaka, C; Ochi, Y; Umezawa, K	1
Bismuto, E; Irace, G; Nucci, R; Rossi, M	1
Hembre, EJ; Patterson, DE; Trost, BM	1
Takahashi, H	1
Breithaupt, AT; Collins, W; Kireev, AS; Kornienko, A; Nadein, ON	1
Bundgaard, E; Hansen, FG; Madsen, R	1
Davies, GJ; Gloster, TM; Madsen, R	1
Ikegami, S; Takahashi, H	1
Aerts, JM; Aten, J; Bleijlevens, B; Boot, RG; Donker-Koopman, WE; Florea, BI; Hollak, CE; Hooibrink, B; Kallemeijn, WW; Kramer, G; Li, KY; Ottenhoff, R; Overkleeft, HS; Strijland, A; van den Nieuwendijk, AM; van der Marel, GA; Witte, MD	1
Chen, CF; Ketudat Cairns, JR; Kuaprasert, B; Pengthaisong, S; Withers, SG	1
Aerts, JM; Aten, J; Boot, RG; Codée, JD; Florea, BI; Jiang, J; Kallemeijn, WW; Li, KY; Marques, AR; Ottenhoff, R; Overkleeft, HS; Scheij, S; van den Elst, H; van der Marel, GA; van Roomen, CP; Voorn-Brouwer, TM; Walvoort, MT; Willems, LI; Witte, MD	1
Mondal, S; Prathap, A; Sureshan, KM	1
Chandrasekar, B; Colby, T; Emran Khan Emon, A; Harzen, A; Hong, TN; Jiang, J; Overkleeft, HS; van der Hoorn, RA; Villamor, JG	1
Aerts, JM; Boot, RG; Codée, JD; Donker-Koopman, WE; Jiang, J; Kallemeijn, WW; Li, KY; Overkleeft, HS; van der Marel, GA; Witte, MD	1
Aerts, JM; Boot, RG; Codée, JD; Kallemeijn, WW; Li, KY; Overkleeft, HS; van der Marel, GA; Voorn-Brouwer, TM; Walvoort, MT; Witte, MD	1
Bujons, J; Egido-Gabás, M; Llebaria, A; Trapero, A	1
Aerts, JM; Beenakker, TJ; Codée, JD; Jiang, J; Kallemeijn, WW; Overkleeft, HS; van den Elst, H; van der Marel, GA	1
Chen, HM; Davies, GJ; Jiang, J; Jin, Y; Kötzler, MP; Kwan, DH; Overkleeft, HS; Withers, SG	1
Brayer, GD; Caner, S; Chen, HM; Jiang, J; Nguyen, NT; Overkleeft, H; Withers, SG; Zhang, X	1
Aerts, JM; Ben Bdira, F; Bleijlevens, B; Boot, R; de Haan, A; Florea, BI; Jiang, J; Kallemeijn, W; Overkleeft, HS; Ubbink, M	1
Aerts, JMFG; Artola, M; Beenakker, TJM; Codée, JDC; Davies, GJ; Ferraz, MJ; Hansen, T; Houben, JHPM; Li, KY; Offen, WA; Overkleeft, HS; Raich, L; Rovira, C; van der Marel, GA; van Rijssel, ER; Wander, DPA	1
Absalah, S; Aerts, JMFG; Al-Khakany, H; Boer, DEC; Bouwstra, JA; Dijkhoff, IM; Helder, RWJ; Kallemeijn, WW; Overkleeft, HS; Schreuder, A; van Smeden, J	1
Aerts, JM; Artola, ME; Kallemeijn, WW; Kuo, CL; Kytidou, K; Overkleeft, HS; van Meel, E; Witte, M	1
Aerts, JMFG; Artola, M; Codée, JDC; Florea, BI; Gloster, TM; Hansen, T; He, X; Kermode, AR; Kuo, CL; McMahon, SA; Oehler, V; Overkleeft, HS; van den Elst, H; van der Lienden, M; van der Marel, GA	1
Aerts, JMFG; Artola, M; Futerman, AH; Kallemeijn, WW; Kuo, CL; Lelieveld, LT; Meijer, AH; Mirzaian, M; Overkleeft, HS; Spaink, HP; Vardi, A; Zoutendijk, I	1
Aerts, JMFG; Artola, M; Boot, RG; Codée, JDC; Davies, GJ; Kuo, CL; Lelieveld, LT; Overkleeft, HS; Rowland, RJ; van der Marel, GA	1
Artola, M; Bhatt, AP; Cloer, EW; Davies, GJ; Goldfarb, D; Jariwala, PB; Major, MB; Overkleeft, HS; Pellock, SJ; Redinbo, MR; Roberts, LR; Simpson, JB; Walton, WG	1
Aerts, JMFG; Armstrong, Z; Beenakker, TJM; Boot, RG; Codée, JDC; Davies, GJ; de Boer, C; Debets, MF; Florea, BI; Geurink, PP; Hissink, C; Johnson, R; Kuo, CL; Lahav, D; Liu, B; Ovaa, H; Overkleeft, HS; van der Marel, GM; van der Stelt, M; van Rijssel, ER; Wong, CS; Wu, L	1
Amaki, S; Arakawa, T; Artola, M; Borlandelli, V; Codée, JDC; Coines, J; Davies, GJ; Fushinobu, S; Ishiwata, A; Ito, Y; Linzel, D; McGregor, NGS; Nin-Hill, A; Overkleeft, HS; Rovira, C; van der Marel, GA; Yamada, C	1
Aerts, JMFG; Artola, M; Boot, RG; Ferraz, MJ; Kuo, CL; Lelieveld, LT; Overkleeft, HS; Schröder, SP; Su, Q; Verhoek, M	1
Aerts, JMFG; Armstrong, Z; Beenakker, TJM; Codée, JDC; Davies, GJ; Florea, BI; Kuo, CL; McGregor, NGS; Offen, WA; Overkleeft, HS; Wong, CS	1
Davies, GJ; McGregor, NGS; Overkleeft, HS	1
Aerts, JMFG; Artola, M; Codée, JDC; Davies, GJ; Katzy, RE; Kok, K; Kuo, CL; Lelieveld, LT; Overkleeft, HS; Roig-Zamboni, V; Sulzenbacher, G; van der Marel, GA; Wu, L	1

Reviews

1 review(s) available for cyclophellitol and cyclohexanol

Article	Year
[Synthetic studies on sugar-related bioactive substances based on the ring transformation]. Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan, 2002, Volume: 122, Issue:10 Topics: Carbohydrates; Catalysis; Cyclization; Cyclohexanols; Cyclohexanones; Drug Design; Inositol; Inositol Phosphates; Lactones; Palladium	2002

Other Studies

41 other study(ies) available for cyclophellitol and cyclohexanol

Article	Year
Inhibition of glucocerebrosidase and induction of neural abnormality by cyclophellitol in mice. Archives of biochemistry and biophysics, 1992, Volume: 297, Issue:2 Topics: Animals; beta-Glucosidase; beta-N-Acetylhexosaminidases; Brain; Cyclohexanols; Female; Glucosylceramidase; Kidney; Kinetics; Liver; Mice; Mice, Inbred Strains; Muscles; Spleen; Time Factors	1992
Enantiospecific synthesis and biological evaluation of 1,6-epi-cyclophellitol. The Journal of antibiotics, 1991, Volume: 44, Issue:4 Topics: Basidiomycota; beta-Glucosidase; Chemical Phenomena; Chemistry; Crystallization; Cyclohexanols; Magnetic Resonance Spectroscopy; Molecular Structure; Stereoisomerism	1991
Cyclophellitol: a naturally occurring mechanism-based inactivator of beta-glucosidases. Biochemical and biophysical research communications, 1991, May-31, Volume: 177, Issue:1 Topics: Alcaligenes; beta-Glucosidase; Cyclohexanols; Escherichia coli; Kinetics; Plants; Recombinant Proteins	1991
Syntheses and enzyme inhibiting activities of cyclophellitol analogs. The Journal of antibiotics, 1991, Volume: 44, Issue:8 Topics: beta-Glucosidase; Cyclohexanols	1991
Production, isolation and structure determination of a novel beta-glucosidase inhibitor, cyclophellitol, from Phellinus sp. The Journal of antibiotics, 1990, Volume: 43, Issue:1 Topics: Basidiomycota; beta-Glucosidase; Crystallography; Cyclohexanols; Fermentation; Glucosidases; Molecular Structure	1990
Biological activities of cyclophellitol. The Journal of antibiotics, 1990, Volume: 43, Issue:12 Topics: 1-Deoxynojirimycin; Animals; Anti-Bacterial Agents; beta-Glucosidase; Binding, Competitive; Body Weight; Cell Line; Cyclohexanols; Female; Glucosamine; Glucosylceramidase; Indolizines; Mice; Microsomes; Tumor Cells, Cultured	1990
Kinetic studies on cyclophellitol analogues--mechanism-based inactivators. Biochemical and biophysical research communications, 1995, Aug-04, Volume: 213, Issue:1 Topics: alpha-Mannosidase; beta-Glucosidase; Cyclohexanols; Glycoside Hydrolase Inhibitors; Kinetics; Mannosidases; Saccharomyces cerevisiae; Stereoisomerism; Structure-Activity Relationship	1995
A family of cyclophellitol analogs: synthesis and evaluation. The Journal of antibiotics, 1993, Volume: 46, Issue:12 Topics: Cyclohexanols; Drug Stability; Glycoside Hydrolases; Magnetic Resonance Spectroscopy; Structure-Activity Relationship	1993
Accumulation of tissue glucosylsphingosine in Gaucher-like mouse induced by the glucosylceramidase inhibitor cyclophellitol. Archives of biochemistry and biophysics, 1993, Volume: 304, Issue:1 Topics: Animals; Brain; Cells, Cultured; Cyclohexanols; Disease Models, Animal; Gaucher Disease; Glucosylceramidase; In Vitro Techniques; Liver; Mice; Psychosine; Spleen	1993
Inhibition of experimental metastasis by an alpha-glucosidase inhibitor, 1,6-epi-cyclophellitol. Cancer research, 1993, Oct-15, Volume: 53, Issue:20 Topics: alpha-Glucosidases; Animals; Antineoplastic Agents; beta-Glucosidase; Cell Adhesion; Cell Line; Cyclohexanols; Female; Glycoside Hydrolase Inhibitors; Kinetics; Lung Neoplasms; Melanoma, Experimental; Mice; Mice, Inbred C57BL; Neoplasm Invasiveness; Neoplasm Metastasis	1993
Structural and dynamic aspects of beta-glycosidase from mesophilic and thermophilic bacteria by multitryptophanyl emission decay studies. Proteins, 1999, May-01, Volume: 35, Issue:2 Topics: beta-Glucosidase; Cyclohexanols; Enzyme Inhibitors; Escherichia coli; Guanidine; Protein Folding; Protein Structure, Secondary; Spectrometry, Fluorescence; Sulfolobus; Tryptophan	1999
AAA in KAT/DYKAT processes: first- and second-generation asymmetric syntheses of (+)- and (-)-cyclophellitol. Chemistry (Weinheim an der Bergstrasse, Germany), 2001, Sep-03, Volume: 7, Issue:17 Topics: Agaricales; Anti-HIV Agents; beta-Glucosidase; Catalysis; Cyclohexanols; Enzyme Inhibitors; Methods; Rhenium; Stereoisomerism	2001
Enantiodivergent formal synthesis of (+)- and (-)-cyclophellitol from D-xylose based on the latent symmetry concept. The Journal of organic chemistry, 2005, Jan-21, Volume: 70, Issue:2 Topics: Cyclohexanols; Molecular Structure; Stereoisomerism; Xylose	2005
A short synthesis of (+)-cyclophellitol. The Journal of organic chemistry, 2005, Nov-25, Volume: 70, Issue:24 Topics: beta-Glucosidase; Cyclohexanols; Enzyme Inhibitors; Molecular Conformation; Stereoisomerism; Xylose	2005
Structural basis for cyclophellitol inhibition of a beta-glucosidase. Organic & biomolecular chemistry, 2007, Feb-07, Volume: 5, Issue:3 Topics: beta-Glucosidase; Crystallography, X-Ray; Cyclohexanols; Enzyme Inhibitors; Enzyme Stability; Hydrolysis; Kinetics; Mass Spectrometry	2007
Synthesis of cyclophellitol utilizing a palladium chloride mediated-Ferrier-II rearrangement. Molecules (Basel, Switzerland), 2005, Aug-31, Volume: 10, Issue:8 Topics: Cyclohexanols; Models, Chemical; Molecular Conformation; Palladium; Temperature	2005
Ultrasensitive in situ visualization of active glucocerebrosidase molecules. Nature chemical biology, 2010, Volume: 6, Issue:12 Topics: Animals; Boron Compounds; Cells, Cultured; Cyclohexanols; Drug Design; Electrophoresis, Polyacrylamide Gel; Enzyme Inhibitors; Enzyme-Linked Immunosorbent Assay; Fibroblasts; Flow Cytometry; Fluorescent Dyes; Gaucher Disease; Glucosylceramidase; Imino Pyranoses; Mice; Microscopy, Fluorescence; Molecular Chaperones	2010
Rice BGlu1 glycosynthase and wild type transglycosylation activities distinguished by cyclophellitol inhibition. Carbohydrate research, 2012, May-01, Volume: 352 Topics: Carbohydrate Sequence; Cyclohexanols; Disaccharides; Enzyme Inhibitors; Glycosylation; Ligases; Molecular Sequence Data; Mutation; Oryza	2012
Novel activity-based probes for broad-spectrum profiling of retaining β-exoglucosidases in situ and in vivo. Angewandte Chemie (International ed. in English), 2012, Dec-07, Volume: 51, Issue:50 Topics: Animals; Aziridines; Brain; Cellulases; Cyclohexanols; Fluorescent Dyes; Hep G2 Cells; Humans; Isomerism; Mice; Proteomics; Recombinant Proteins	2012
Vinylogy in orthoester hydrolysis: total syntheses of cyclophellitol, valienamine, gabosine K, valienone, gabosine G, 1-epi-streptol, streptol, and uvamalol A. The Journal of organic chemistry, 2013, Aug-02, Volume: 78, Issue:15 Topics: Cyclohexanols; Cyclohexanones; Cyclohexenes; Esters; Hexosamines; Hydrolysis; Molecular Conformation	2013
Broad-range glycosidase activity profiling. Molecular & cellular proteomics : MCP, 2014, Volume: 13, Issue:10 Topics: Arabidopsis; Arabidopsis Proteins; Aziridines; Catalytic Domain; Cell Wall; Cyclohexanols; Glycoside Hydrolases; Mass Spectrometry; Molecular Probes; Phylogeny; Proteomics	2014
Exploring functional cyclophellitol analogues as human retaining beta-glucosidase inhibitors. Organic & biomolecular chemistry, 2014, Oct-21, Volume: 12, Issue:39 Topics: beta-Glucosidase; Cyclohexanols; Enzyme Inhibitors; Humans	2014
A sensitive gel-based method combining distinct cyclophellitol-based probes for the identification of acid/base residues in human retaining β-glucosidases. The Journal of biological chemistry, 2014, Dec-19, Volume: 289, Issue:51 Topics: Amino Acid Substitution; Amino Acids; Animals; Aziridines; beta-Glucosidase; Catalytic Domain; Chlorocebus aethiops; COS Cells; Cyclohexanols; Epoxy Compounds; Humans; Hydrolysis; Immunoblotting; Molecular Probes; Mutagenesis, Site-Directed; Mutation, Missense; Reproducibility of Results; Sodium Azide; Substrate Specificity	2014
Synthesis and evaluation of hydroxymethylaminocyclitols as glycosidase inhibitors. The Journal of organic chemistry, 2015, Apr-03, Volume: 80, Issue:7 Topics: alpha-Glucosidases; beta-Glucosidase; Cyclitols; Cyclohexanols; Enzyme Inhibitors; Glucosylceramidase; Kinetics; Structure-Activity Relationship	2015
Comparing Cyclophellitol N-Alkyl and N-Acyl Cyclophellitol Aziridines as Activity-Based Glycosidase Probes. Chemistry (Weinheim an der Bergstrasse, Germany), 2015, Jul-20, Volume: 21, Issue:30 Topics: alpha-Glucosidases; alpha-L-Fucosidase; Animals; Aziridines; beta-Glucosidase; Cell Line; Chlorocebus aethiops; COS Cells; Cyclohexanols; Electrophoresis, Polyacrylamide Gel; Fluorescent Dyes	2015
Chemoenzymatic synthesis of 6-phospho-cyclophellitol as a novel probe of 6-phospho-β-glucosidases. FEBS letters, 2016, Volume: 590, Issue:4 Topics: Catalytic Domain; Coenzymes; Crystallography, X-Ray; Cyclohexanols; Enzyme Inhibitors; Glucosidases; Molecular Probes; Protein Conformation; Streptococcus pyogenes	2016
Glucosyl epi-cyclophellitol allows mechanism-based inactivation and structural analysis of human pancreatic α-amylase. FEBS letters, 2016, Volume: 590, Issue:8 Topics: Catalytic Domain; Computer Simulation; Cyclohexanols; Disaccharides; Epoxy Compounds; Humans; Hydrogen Bonding; Inositol; Kinetics; Mass Spectrometry; Models, Molecular; Pancreatic alpha-Amylases; Water; X-Ray Diffraction	2016
Hydrophobic Interactions Contribute to Conformational Stabilization of Endoglycoceramidase II by Mechanism-Based Probes. Biochemistry, 2016, 08-30, Volume: 55, Issue:34 Topics: Amino Acid Sequence; Bacterial Proteins; Catalytic Domain; Cyclohexanols; Enzyme Stability; Gaucher Disease; Glucosylceramidase; Glycoside Hydrolases; Humans; Hydrophobic and Hydrophilic Interactions; Models, Molecular; Molecular Probes; Protein Conformation; Recombinant Proteins; Rhodococcus; Structural Homology, Protein	2016
Carba-cyclophellitols Are Neutral Retaining-Glucosidase Inhibitors. Journal of the American Chemical Society, 2017, 05-17, Volume: 139, Issue:19 Topics: alpha-Glucosidases; Cyclohexanols; Glycoside Hydrolase Inhibitors; Models, Molecular; Molecular Structure; Quantum Theory; Thermotoga maritima	2017
In situ visualization of glucocerebrosidase in human skin tissue: zymography versus activity-based probe labeling. Journal of lipid research, 2017, Volume: 58, Issue:12 Topics: Benzoxazines; Boron Compounds; Cyclohexanols; Enzyme Assays; Epoxy Compounds; Fluorescent Dyes; Gene Expression; Glucosides; Glucosylceramidase; Humans; Hymecromone; Skin; Staining and Labeling; Tissue Culture Techniques	2017
Activity-Based Probes for Glycosidases: Profiling and Other Applications. Methods in enzymology, 2018, Volume: 598 Topics: Cell Line; Cyclohexanols; Enzyme Assays; Enzyme Inhibitors; Fibroblasts; Fluorescent Dyes; Gaucher Disease; Glucosylceramidase; Glycosphingolipids; Humans; Lysosomes; Microscopy, Confocal; Microscopy, Fluorescence; Molecular Probes; Staining and Labeling	2018
New Irreversible α-l-Iduronidase Inhibitors and Activity-Based Probes. Chemistry (Weinheim an der Bergstrasse, Germany), 2018, Dec-17, Volume: 24, Issue:71 Topics: Aziridines; Chromatography, Liquid; Cyclohexanols; Enzyme Assays; Enzyme Inhibitors; Fluorescent Dyes; Humans; Iduronidase; Microscopy, Fluorescence; Models, Molecular; Recombinant Proteins; Staining and Labeling; Tandem Mass Spectrometry	2018
In vivo inactivation of glycosidases by conduritol B epoxide and cyclophellitol as revealed by activity-based protein profiling. The FEBS journal, 2019, Volume: 286, Issue:3 Topics: Animals; beta-Glucosidase; Brain; Cyclohexanols; Disease Models, Animal; Enzyme Assays; Glucosylceramidase; Glycoside Hydrolase Inhibitors; HEK293 Cells; Humans; Inositol; Isoenzymes; Kinetics; Larva; Lysosomes; Mice; Parkinson Disease; Zebrafish	2019
Functionalized Cyclophellitols Are Selective Glucocerebrosidase Inhibitors and Induce a Bona Fide Neuropathic Gaucher Model in Zebrafish. Journal of the American Chemical Society, 2019, 03-13, Volume: 141, Issue:10 Topics: Animals; Cyclohexanols; Disease Models, Animal; Enzyme Inhibitors; Gaucher Disease; Glucosylceramidase; Humans; Zebrafish; Zebrafish Proteins	2019
Discovering the Microbial Enzymes Driving Drug Toxicity with Activity-Based Protein Profiling. ACS chemical biology, 2020, 01-17, Volume: 15, Issue:1 Topics: Animals; Bacterial Proteins; Biomarkers; Computational Biology; Cyclohexanols; Drug-Related Side Effects and Adverse Reactions; Enzyme Inhibitors; Feces; Female; Gastrointestinal Microbiome; Glucuronidase; Glucuronides; Humans; Hydrolysis; Irinotecan; Kinetics; Male; Metabolome; Mice; Models, Molecular; Precision Medicine; Protein Binding; Protein Conformation	2020
Manno- Journal of the American Chemical Society, 2020, 07-29, Volume: 142, Issue:30 Topics: Cyclohexanols; Drug Discovery; Enzyme Inhibitors; Humans; Mannosidases; Molecular Structure	2020
Cysteine Nucleophiles in Glycosidase Catalysis: Application of a Covalent β-l-Arabinofuranosidase Inhibitor. Angewandte Chemie (International ed. in English), 2021, 03-08, Volume: 60, Issue:11 Topics: Biocatalysis; Crystallography, X-Ray; Cyclohexanols; Cysteine; Density Functional Theory; Enzyme Inhibitors; Glycoside Hydrolases; Molecular Dynamics Simulation; Molecular Structure	2021
Xylose-Configured Cyclophellitols as Selective Inhibitors for Glucocerebrosidase. Chembiochem : a European journal of chemical biology, 2021, 11-03, Volume: 22, Issue:21 Topics: Animals; Cells, Cultured; Cyclohexanols; Enzyme Inhibitors; Glucosylceramidase; HEK293 Cells; Humans; Molecular Conformation; Xylose; Zebrafish	2021
Synthesis of broad-specificity activity-based probes for Organic & biomolecular chemistry, 2022, 01-26, Volume: 20, Issue:4 Topics: beta-Mannosidase; Cyclohexanols; Molecular Conformation; Molecular Probes	2022
Detecting and identifying glycoside hydrolases using cyclophellitol-derived activity-based probes. Methods in enzymology, 2022, Volume: 664 Topics: Catalysis; Cyclohexanols; Glycoside Hydrolases	2022
1,6- Journal of the American Chemical Society, 2022, 08-17, Volume: 144, Issue:32 Topics: alpha-Glucosidases; Animals; Cyclohexanols; Glucan 1,4-alpha-Glucosidase; Glycogen; Glycogen Storage Disease Type II; Glycoside Hydrolase Inhibitors; Humans; Zebrafish	2022