Page last updated: 2024-08-21

cyclopentane and pevonedistat

cyclopentane has been researched along with pevonedistat in 265 studies

Research

Studies (265)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	2 (0.75)	29.6817
2010's	200 (75.47)	24.3611
2020's	63 (23.77)	2.80

Authors

Authors	Studies
Adhikari, S; Berger, AJ; Bolen, JB; Brownell, JE; Burke, KE; Cardin, DP; Claiborne, CF; Critchley, S; Cullis, CA; Dick, LR; Doucette, A; Garnsey, JJ; Gaulin, JL; Gavin, JM; Gershman, RE; Langston, SP; Lublinsky, AR; McDonald, A; Milhollen, MA; Mizutani, H; Narayanan, U; Olhava, EJ; Peluso, S; Rezaei, M; Rolfe, M; Sintchak, MD; Smith, PG; Soucy, TA; Talreja, T; Thomas, MP; Traore, T; Vyskocil, S; Weatherhead, GS; Yu, J; Zhang, J	1
Rolfe, M; Smith, PG; Soucy, TA	1
Bolen, JB; Brownell, JE; Bruzzese, FJ; Bump, NJ; Burkhardt, AL; Claiborne, CF; Cullis, CA; Dick, LR; Gavin, JM; Hamman, KB; Langston, SP; Li, P; Liao, H; Lingaraj, T; Loke, HK; Ma, J; Mallender, WD; Milhollen, MA; Rolfe, M; Sells, TB; Sintchak, MD; Soucy, TA; Spelman, JJ; Visiers, I; Vyskocil, S; Wu, D; Yang, X	1
Carew, JS; Garnsey, JJ; Giles, FJ; Kelly, KR; Mahalingam, D; Medina, E; Nawrocki, ST; O'Dwyer, M; Oberheu, K; Padmanabhan, S; Smith, PG; Swords, RT	1
Chen, ZJ; Skaug, B	1
Adams-Duffy, J; Berger, AJ; Bolen, JB; Dang, L; Dick, LR; Garnsey, JJ; Koenig, E; Langston, SP; Manfredi, M; Milhollen, MA; Narayanan, U; Rolfe, M; Smith, PG; Soucy, TA; Staudt, LM; Thomas, MP; Traore, T; Yu, J; Zhang, J	1
Choo, YY; Hagen, T; Leck, YC; Smith, PG; Tan, CY	1
Bennett, EJ; Gygi, SP; Harper, JW; Rush, J	1
Dutta, A; Lin, JJ; Milhollen, MA; Narayanan, U; Smith, PG	1
Deshaies, RJ; Graham, RL; Hess, S; Kolawa, NJ; Lee, JE; Smith, GT; Sweredoski, MJ	1
Abagyan, R; Chan, DS; Fong, WF; Lee, SM; Leung, CH; Ma, DL; Yang, H; Zhu, GY	1
Choi, WJ; Jeong, LS; Kim, HO; Lee, HW; Nam, SK	1
Amidon, B; Milhollen, MA; Narayanan, U; Smith, PG; Soucy, TA; Veiby, PO	1
Dohmann, EM; Hakenjos, JP; Isono, E; Katsiarimpa, A; Richter, R; Schwechheimer, C	1
Jia, L; Li, H; Sun, Y	1
Harper, JW; Lim, HJ; Tan, MK	1
Bernard, H; Blank, JL; Bouck, DC; Garcia, K; Liao, H; Lightcap, ES; Liu, XJ	1
Khuri, FR; Lonial, S; Sun, SY; Yue, P; Zhao, L	1
Chen, YN; Elia, AE; Elledge, SJ; Emanuele, MJ; Guo, A; Hsu, PW; Izhar, L; Leng, Y; Rush, J; Thoma, CR; Xu, Q; Yen, HC	1
Germanos, MS; Manfredi, MG; Robertson, R; Silva, MD; Smith, PG	1
Carol, H; Gorlick, R; Houghton, PJ; Kang, MH; Keir, ST; Kolb, EA; Lock, R; Maris, JM; Morton, CL; Reynolds, CP; Smith, MA; Smith, PG; Wu, J; Yu, J	1
Kirkwood, KJ; Lamond, AI; Larance, M; Lundberg, E; Uhlen, M; Xirodimas, DP	1
Lawrence, TS; Li, H; Morgan, MA; Sebolt, JT; Smith, PG; Sun, Y; Wei, D; Yu, J; Zhao, L	1
Li, Y; Sun, Y; Tan, M; Xi, N; Yang, R	1
Chan, CH; Gao, Y; Lin, HK; Wang, G	1
Chang, S; D'Andrea, AD; Huang, M; Kee, Y; Moreau, LA; Park, E; Smith, PG	1
Kamitani, T; Nakatani, T; Tanaka, T	2
Leidecker, O; Mahata, B; Matic, I; Pion, E; Xirodimas, DP	1
Amidon, BS; Bence, NF; Bolen, JB; Brownell, J; Dick, LR; Gavin, JM; Koenig, EM; Loke, HK; Ma, J; Manfredi, MG; McDonald, AA; Milhollen, MA; Narayanan, U; Riceberg, J; Sells, TB; Sintchak, MD; Smith, PG; Thomas, MP; Traore, T; Xu, Q; Yang, X	1
Sun, Y; Tan, M; Wang, G; Yang, D	1
Chu, Y; Ding, C; Jeong, LS; Jia, L; Lee, HW; Li, L; Liu, J; Luo, Z; Pan, Y; Qian, J; Sun, Y; Wang, L; Wang, X; Wu, L; Yang, D; Yi, J; Yu, G	1
Hjerpe, R; Kurz, T; Thomas, Y	1
de Álava, E; García-Domínguez, DJ; Ginel-Picardo, A; Mackintosh, C; Ordóñez, JL; Sacristán, MP; Smith, PG	1
Carew, JS; Griffin, P; Kelly, KR; Nawrocki, ST	1
Dahl, R; Petroski, MD; Toth, JI; Yang, L	1
Jeong, LS; Jia, L; Liu, J; Luo, Z; Pan, Y	1
Chang, FM; Granados, JC; Innis-Whitehouse, W; Maffi, SK; Reyna, SM; Rodriguez, E; Short, JD; Slaga, TJ; Wei, SJ	1
Jia, L; Sun, Y; Xiong, X; Zhao, Y	1
Bernard, H; Blank, JL; Bouck, DC; Cosmopoulos, K; Garcia, K; Hather, G; Lightcap, ES; Liu, R; Liu, XJ; Milhollen, MA; Narayanan, U; Tayber, O	1
Chan, DS; Leung, CH; Ma, DL; Wang, HM; Yang, H; Zhong, HJ	1
Jin, HS; Liao, L; Liu, YC; Park, Y	1
Bartholomeeusen, K; Cartozo, NC; Crosby, DC; Gross, JD; Harris, RS; Hayashi, F; Jäger, S; Kim, DY; Krogan, NJ; Kwon, E; Li, M; Mason-Herr, J; Peterlin, BM; Stanley, DJ; Yen, L; Yokoyama, S	1
Downs, CA; Helms, MN; Johnson, NM; Kreiner, LH; Kumar, A	1
Chu, Y; Dong, T; Gao, H; Jeong, LS; Jia, L; Lee, HW; Li, L; Liu, B; Liu, G; Niu, W; Yu, J; Zhang, Y; Zheng, S; Zheng, Y	1
Bargou, RC; Giner, T; Maier, E; Rauert-Wunderlich, H; Siegmund, D; Stühmer, T; Wajant, H	1
Hagen, T; Tan, CY	1
Bembenek, ME; Brauer, P; Burkhardt, A; Chen, J; Dick, LR; Garcia, K; Lin, Y; Loke, HK; Ma, J; Xu, Q; Yan, ZH	1
Beausoleil, SA; Berger, A; Blakemore, S; Carew, JS; Espitia, CM; Kelly, KR; Milhollen, M; Nawrocki, ST; Possemato, A; Smith, PG; Thomas, M	1
Chang, C; Ding, C; Fu, T; He, F; Jia, L; Jiang, J; Liu, M; Liu, W; Lu, T; Ma, J; Malovannaya, A; Qian, X; Qin, J; Song, L; Wang, Y; Wei, J; Wei, L; Ying, W; Zhang, W; Zhang, Y; Zhen, B	1
Brownell, JE; Dick, LR; Li, P; Liao, H; Loke, HK; Ma, J; Mallender, WD; Minissale, JJ; Rollins, N; Soucy, TA; Thomas, MP; Xu, Q; Yang, X; Zhu, F	1
Mishra, A; Singh, A; Verma, S	1
Hou, G; Kapeles, S; Mathewson, N; Oravecz-Wilson, K; Reddy, P; Sun, Y; Tamaki, H; Toubai, T; Wang, Y	1
Berger, AJ; Bryant, JL; Conaway, MR; Dutta, A; Jazaeri, AA; Milhollen, MA; Modesitt, SC; Park, J; Shibata, E; Smith, PG	1
Hofmann, H; Landau, NR; Norton, TD; Polsky, SB; Schultz, ML; Sunseri, N	1
Fan, HY; Guo, LJ; Pan, WW; Song, FZ; Xu, Y; Yu, C; Zhang, HY; Zhou, D; Zhou, JJ	1
Alpi, AF; Duda, DM; Hofmann, K; Kelsall, IR; Knebel, A; Langevin, F; Olszewski, JL; Schulman, BA; Wightman, M; Wood, N	1
Guo, H; Liu, X; Luo, K; Markham, RB; Qian, L; Wei, W; Yu, XF; Zhang, H	1
Li, H; Sun, Y; Tan, M	1
Berger, A; Blakemore, SJ; Bowman, D; Burke, KE; Chakravarty, A; Ecsedy, J; Fleming, M; McDonald, AA; Shinde, V; Tirrell, SM	1
Nakasone, A; Oono, Y	1
Chen, P; Cheng, H; Chu, YW; Hoffman, RM; Hua, ZC; Jeong, LS; Jia, LJ; Jiang, YN; Lee, HW; Li, LH; Qi, H; Wang, K; Wang, P; Wang, R; Wu, JF; Yang, M; Yao, WT; Ying, HQ; Yu, GY; Yu, J; Yu, XJ	1
Brown, JR; Danilov, AV; Danilova, OV; Eastman, A; Godbersen, JC; Humphries, LA; Kebbekus, PE	1
Chan, DS; Chan, PW; Leung, CH; Liu, LJ; Ma, DL; Wang, HM; Zhong, HJ	1
Bandi, S; Blank, JL; Bouck, DC; Cosmopoulos, K; Garcia, K; Hather, G; Kuranda, M; Lightcap, ES; Liu, R; Liu, XJ; Pickard, MD; Sappal, DS; Smith, PG; Thomas, MP	1
Bhattacharjee, RN; da Silva, SR; Dhe-Paganon, S; Goard, CA; Gunning, PT; Hurren, R; Lukkarila, JL; Maclean, N; Medeiros, B; Paiva, SL; Petroski, MD; Schimmer, AD; Sukhai, MA; Toth, JI; Xu, GW	1
Bernal, L; Boise, LH; Chen, J; Gu, Y; Harvey, RD; Kaufman, JL; Lonial, S; Matulis, SM; Sun, SY; Torre, C	1
Chen, P; Chu, Y; Dong, Z; Gao, Q; Hoffman, RM; Hu, F; Jeong, LS; Jia, H; Jia, L; Lee, HW; Li, C; Li, H; Li, L; Mei, J; Qi, H; Shi, J; Sun, Y; Wang, M; Wang, P; Wang, Y; Wei, D; Xie, L; Yang, M; Yao, W; Yu, G; Yu, J; Zhu, J	1
Feng, Y; Fu, S; Guo, X; Jeong, LS; Jia, L; Li, C; Li, L; Liang, Y; Sun, M; Wang, X; Ye, D; Zhao, H	1
Duan, M; Fan, J; Gao, Q; Jeong, LS; Jia, LJ; Li, LH; Qiu, SJ; Shi, JY; Wang, XY; Wang, ZC; Yang, LX; Yu, GY; Zhang, WJ; Zhao, H; Zhou, J	1
Friedman, JM; Kawabe, T; Kufe, DW; Saito, N; Sakakibara, K; Sato, T; VonHoff, DD	1
Bayless, A; Campbell, EL; Colgan, SP; Curtis, VF; Ehrentraut, SF; Glover, LE; Kelly, CJ; Kominsky, DJ	1
El-Mesery, M; Seher, A; Siegmund, D; Stühmer, T; Wajant, H	1
Carew, JS; Carraway, H; Keaton, M; Kelly, KR; Maciejewski, JP; Nawrocki, ST; Sekeres, MA; Smith, PG	1
Chang, HC; Chang, SC; Chou, CT; Ho, IL; Hsieh, JT; Hsu, CH; Huang, KH; Kuo, KL; Lin, WC; Pu, YS; Shi, CS; Tsai, YC; Wu, JT	1
Aspichueta, P; Barbier-Torres, L; Beraza, N; Boix, L; Bruix, J; Buqué, X; Cano, A; Castro, A; Delgado, TC; Fernández-Domínguez, I; Fernández-Ramos, D; Fernández-Tussy, P; García-Rodríguez, JL; Gutiérrez-de Juan, V; Lopitz-Otsoa, F; Lu, SC; Martínez-Chantar, ML; Mato, JM; Varela-Rey, M; Villa, E; Xirodimas, D; Zubiete-Franco, I	1
Bergman, Y; Berkowitz, DE; Hori, D; Kim, JH; Pandey, D; Romer, LH	1
Patrick, GN; Scudder, SL	1
Altman, JK; Bixby, DL; Blakemore, SJ; DeAngelo, DJ; Dezube, BJ; Erba, HP; Faessel, H; Giles, FJ; Hua, Z; Maris, M; Medeiros, BC; Sedarati, F; Swords, RT	1
Jia, L; Jiang, Y	1
Chu, Y; Jeong, LS; Jia, L; Liu, J; Luo, Z; Pan, Y; Wang, W; Wang, Y; Zhou, X	1
Baquero-Pérez, B; Hughes, DJ; Jackson, BR; Whitehouse, A; Wood, JJ	1
Chen, P; Chu, Y; Dong, Z; Hoffman, RM; Hu, T; Jeong, LS; Jia, L; Jiang, Y; Li, C; Li, P; Liang, Y; Pan, Y; Qi, H; Wei, D; Yang, M; Zhang, P	1
Bailly, A; Bou Malhab, LJ; Gleizes, PE; Lamond, AI; Larance, M; Nagala, M; O'Donohue, MF; Perrin, A; Pion, E; Smith, P; Xirodimas, DP; Zomerdijk, J	1
Chu, Y; Duan, S; Hua, W; Jia, L; Jiang, Y; Li, C; Li, L; Liu, Z; Mao, Y; Yang, M; Yang, Z; Yu, G; Zhang, Y; Zhu, W	1
Beli, P; Britton, S; Brown, JS; Calsou, P; Galanty, Y; Jackson, SP; le Sage, C; Lukashchuk, N; Sczaniecka-Clift, M	1
Alachkar, H; Anghelina, M; Bloomfield, CD; Caligiuri, MA; Croce, CM; Curfman, J; Dorrance, A; Garzon, R; Guzman, ML; Huang, X; Khalife, J; Lee, LJ; Lee, RJ; Marcucci, G; Medeiros, BC; Mendler, JH; Neviani, P; Perrotti, D; Pichiorri, F; Radomska, HS; Santhanam, R; Saultz, J; Wang, H; Wu, YZ	1
Dai, H; Hess, AD; Karp, JE; Kaufmann, SH; Knorr, KL; Meng, XW; Schneider, PA; Smith, BD	1
Li, G; Wan, J; Zhang, Z; Zhu, J	1
Berger, A; Brown, JR; Danilov, AV; Danilova, OV; Godbersen, JC; Paiva, C	1
Gu, Z; Huang, J; Thomas, GS; Tricot, G; Xu, H; Yang, Y; Zhan, F; Zhou, Y	1
Berger, A; Brown, JR; Danilov, AV; Godbersen, JC; Paiva, C	1
Barker, E; Bosque, A; DePaula-Silva, AB; Planelles, V; Ramirez, PW; Szaniawski, M	1
Baradaran, B; Farajollahi, A; Islamian, JP; Mohammadi, M; Monfared, AS; Oladghaffari, M; Shanehbandi, D	1
Baradaran, B; Islamian, JP; Monfared, AS; Oladghaffari, M	1
Chen, P; Chu, Y; Hou, D; Liu, F; Liu, H; Liu, J; Luo, Z; Lv, B; Ma, Y; Wu, L; Yang, D; Yu, S; Zhang, J; Zhang, Q	1
Advani, AS; Beausoleil, SA; Carew, JS; Carraway, HE; Espitia, CM; Han, Y; Kelly, KR; Maciejewski, JP; Nawrocki, ST; Nazha, A; Possemato, A; Sekeres, MA; Visconte, V	1
Broxmeyer, HE; Lahm, T; Lakhter, AJ; Naidu, SR	1
Berger, AJ; Burke, K; Clark, JW; Cleary, JM; Cohen, RB; Dezube, BJ; Faessel, HM; Harvey, RD; Kauh, JS; Mahalingam, D; Mulligan, G; Pickard, MD; Sarantopoulos, J; Shapiro, GI; Weiss, GJ	1
Berger, AJ; Dezube, BJ; Diefenbach, C; Faessel, HM; Harvey, RD; Hua, Z; Jakubowiak, AJ; Kelly, K; Lebovic, D; Lonial, S; Mulligan, G; O'Connor, OA; Orlowski, RZ; Shah, JJ; Smith, MR; Tirrell, S	1
Chang, HC; Chiang, CK; Chou, CT; Ho, IL; Hsieh, JT; Hsu, CH; Huang, KH; Kuo, KL; Lin, WC; Liu, SH; Pu, YS; Shi, CS; Tsai, YC; Wu, JT	1
Barth, MJ; Czuczman, MS; Czuczman, NM; Frys, SE; Gu, J; Hernandez-Ilizaliturri, FJ; Hu, Q; Klener, P; Liu, S; Mavis, C; Neppalli, V; Vockova, P	1
Custodio, DF; de Sousa, GF; Freitas, VM; Lima, Mde A; Monteiro, G	1
Karnak, D; Lawrence, TS; Morgan, MA; Sun, Y; Tan, M; Zhang, Q	1
Bayer, W; Drexler, I; Katschinski, B; Krawczyk, A; Landsberg, CD; Le-Trilling, VT; Megger, DA; Rückborn, MU; Sitek, B; Tao, S; Tenbusch, M; Trilling, M	1
Berger, AJ; Chalasani, S; Chen, S; Dai, Y; Dumur, CI; Ferreira-Gonzalez, A; Grant, S; Kmieciak, M; Leng, Y; Li, L; Lin, H; Povirk, L; Rahmani, M; Rizzo, KA; Zhang, Y; Zhou, L	1
Huai, W; Song, H; Wang, W; Yu, Z; Zhang, L; Zhao, J; Zhao, W	1
Andérica-Romero, AC; Hernández-Damián, J; Pedraza-Chaverri, J; Torres, I; Vázquez-Cervantes, GI	1
Chen, P; Chen, X; Dong, Z; Hao, Q; Hoffman, RM; Hu, T; Jeong, LS; Jia, L; Li, P; Liang, Y; Ma, Y; Qi, H; Wang, J; Yang, M; Yang, S; Yu, J; Zhang, J; Zhang, P; Zhang, Y; Zhao, H	1
Cho, JY; Chun, YS; Jeong, LS; Ju, UI; Kim, JB; Kim, SW; Kim, SY; Lee, HW; Lee, KH; Park, HS; Park, JW; Park, KS; Shin, DH; Song, JY; Yu, J	1
Cao, H; Cao, J; Han, K; Li, X; Qiu, G; Shen, B; Wang, J; Wang, Q; Zhang, J	1
Bhatia, S; Boasberg, P; Dezube, BJ; Faessel, H; Hamid, O; Mulligan, G; Pavlick, AC; Pickard, MD; Thompson, JA	1
Jin, H; Lan, H; Sun, Y; Tang, Z	1
Nyati, MK; Sun, Y; Tan, M; Wang, G; Zhao, Y; Zhou, X	1
Li, GQ; Li, SS; Shi, CC; Zhang, HP; Zhang, Y	1
Feng, Y; Fu, S; Guo, X; Jeong, LS; Jia, L; Li, L; Liang, Y; Wang, X; Yan, Z; Yu, J; Yu, X; Zhang, W; Zhang, Y; Zhao, H	1
Cheng, M; Fan, R; Hu, S; Lin, Y; Liu, X; Pei, Y; Tao, R; Wang, L; Wang, Z; Zhang, M; Zhang, T; Zheng, S; Zhong, J; Zhou, J	1
Abbas, T; Benamar, M; Corbett, P; Du, K; Gioeli, D; Guessous, F; Obeid, J; Slingluff, CL	1
Fujiwara, H; Mathewson, ND; Oravecz-Wilson, K; Reddy, P; Rossi, C; Sun, Y; Toubai, T; Wu, SR; Zajac, C	1
Pei, Y; Qiu, G; Shen, B; Wang, Q; Xu, Y; Ye, Z; Zhang, J; Zhang, X	1
Deng, Z; Jiang, F; Li, JD; Liu, H; Mao, W; Xia, Z; Zhang, J; Zhang, S	1
Barredo, JC; DeSalvo, J; Leclerc, GJ; Leclerc, GM; Swords, RT; Zheng, S	1
Hashimoto, K; Hibino, R; Inazuka, M; Ishikawa, T; Kuida, K; Morimoto, M; Smith, PG; Sumi, H; Yabuki, M; Yoshida, S	1
Bardelli, A; Bertotti, A; Di Nicolantonio, F; Grillone, K; Isella, C; Medico, E; Migliardi, G; Petti, C; Picco, G; Rossi, T; Sapino, A; Sarotto, I; Sassi, F; Trusolino, L	1
Dai, X; Ding, Q; Gan, W; Li, M; Mitsiades, N; Wan, L; Wei, W; Wu, F; Zhang, J	1
Bagby, SM; Berger, A; Blakemore, SJ; Eckhardt, SG; Klauck, PJ; McDonald, A; Micel, LN; Pitts, TM; Selby, HM; Smith, PF; Spreafico, A; Tan, AC; Tentler, JJ; Wong, KM	1
Abedi, M; Chen, M; Khuat, LT; Murphy, WJ; Pai, CS	1
Delaval, B; Descamps, S; Malhab, LJ; Xirodimas, DP	1
Assard, N; Balakirev, MY; Dolega, ME; Gerbaud, S; Gidrol, X; Guyon, L; Kermarrec, F; Mittler, F; Obeid, P; Rulina, AV; Sulpice, E	1
Fujisaki, A; Higashiyama, S; Hiyoshi, H; Izutani, H; Joh, T; Kubota, E; Maekawa, M; Nakayama, H; Sakaue, T	1
Guo, ZP; Hu, YC; Jin, F; Liu, XD; Ma, T; Song, ZQ; Xie, Y; Zhou, PK	1
Aspichueta, P; Aurrekoetxea, I; Barbier-Torres, L; Beraza, N; Caballeria, J; Crespo, J; de Davalillo, SL; Delgado, TC; Duce, AM; Fernández-Ramos, D; Fernández-Tussy, P; Gutiérrez-de Juan, V; Iruzubieta, P; Lopitz-Otsoa, F; Lu, SC; Martínez-Chantar, ML; Mato, JM; Simon, J; Taibo, D; Varela-Rey, M; Villa, E; Zubiete-Franco, I	1
Altman, JK; Anwer, F; DeAngelo, DJ; Dezube, BJ; Erba, HP; Faessel, H; Giles, FJ; Hua, Z; Maris, M; Medeiros, BC; Sedarati, F; Stein, H; Swords, RT; Watts, J	1
Berger, A; Danes, C; Danilov, AV; Danilova, OV; Godbersen, JC; Paiva, C; Rowland, T	1
Fujisaki, A; Hamakawa, H; Higashiyama, S; Imai, Y; Izutani, H; Joh, T; Kubota, E; Nakashiro, KI; Sakakibara, I; Sakaue, T; Uesugi, T	1
Asare, Y; Bernhagen, J; Hennes, T; Jumpertz, S; Schütz, AK	1
Asghari Jafar Abadi, M; Baradaran, B; Farajollahi, A; Mohammadi, M; Oladghaffari, M; Pirayesh Islamian, J; Shabestani Monfared, A; Shanehbandi, D	1
Finn, LE; Foran, JM; Hess, AD; Karp, JE; Kaufmann, SH; Knorr, KL; Smith, BD	1
Chou, TF; Keith, AL; Lee, Y; Pittman, SK; Razani, B; Weihl, CC	1
Li, W; Liang, H; Liu, J; Luo, Z; Min, P; Xiong, P; Xu, D; Zhang, J; Zhang, Z; Zheng, W	1
Jeong, LS; Jia, L; Jiang, Y; Li, L; Liang, Y; Liu, X; Wu, J; Yu, J; Zhang, W	1
Jia, L; Li, H; Li, L; Liu, X; Sun, Y; Wu, J; Zhao, L; Zhou, W	1
Cao, L; Cao, Y; Huang, BJ; Jia, LJ; Luo, DH; Mei, Y; Meng, DF; Peng, LX; Qian, CN; Qiang, YY; Sun, R; Wang, MY; Xiang, YQ; Xie, P; Yang, JP; Yun, JP; Zheng, LS	1
An, H; Kuhn, M; Löbel, M; Misra, M; Schindelin, H; Sotriffer, C; Statsyuk, AV	1
Li, W; Seng, J; Shi, C; Wang, H; Yin, L; Zhang, Y; Zhou, W	1
Jeong, LS; Jia, L; Li, L; Liang, Y; Liu, L; Liu, X; Wang, J; Wang, S; Wang, X; Yu, J; Zhang, W; Zhang, Y; Zhao, H	1
Chang, PJ; Chen, LW; Chen, LY; Hung, CH; Shih, YJ; Wang, SS	1
Jiang, W; Si, Y; Tong, S; Xie, P; Yu, H; Zhang, L	1
Abbas, T; Allak, A; Benamar, M; Guessous, F; Jameson, MJ; Read, PW; Vanderdys, V	1
Girish, KS; Kemparaju, K; Paul, M	1
Ai, TJ; Du, LJ; Duan, SZ; Jia, L; Li, C; Li, L; Liu, J; Liu, Y; Shi, C; Sun, JY; Sun, XN; Xia, Z	1
Kuang, T; Li, JA; Lou, W; Lou, Z; Luo, K; Nowsheen, S; Qin, B; Rong, Y; Song, C; Wang, D; Xu, X; Yuan, J	1
Han, K; Zhang, J	1
Chen, H; Jung, YS; Qian, Y; Sun, H; Wang, K; Yao, W	1
Chun, YS; Lee, GW; Li, L; Park, JW; Park, SY	1
Du, X; Jin, Y; Li, J; Li, Y; Liu, C; Lu, Y; Nie, D; Pan, J; Zhou, J	1
Jia, L; Sun, Y; Zhang, W; Zhou, L	1
Arquint, C; Cubizolles, F; Morand, A; Nigg, EA; Schmidt, A	1
Fathi, AT	1
Bi, R; Chang, J; Deng, Y; Du, Y; Guo, H; Liu, G; Shah, NK; Shu, C; Wang, C; Wei, W; Xu, B	1
Abdi, K; Kuo, CT; Lai, CH; Lay, M; Paez-Gonzalez, P; Pyun, J	1
Chun, YS; Kim, SJ; Lee, GW; Park, JB; Park, JW; Park, SY; Seo, J; Shin, SH; Watanabe, M	1
Li, H; Sun, Y; Tan, M; Wei, W; Xu, J; Zhou, W	1
Aladjem, MI; Baris, AM; Fu, H; Jang, SM; Marks, AB; Redmond, CJ; Redon, CE; Smith, OK; Tulchinsky, DA; Utani, K; Zhang, Y	1
Carson, WE; Duggan, MC; Olaverria Salavaggione, GN	1
Anderson, KC; Cang, Y; Hideshima, T; Ho, M; Liu, J; Peng, Z; Song, T; Tai, YT; Wang, S; Xing, L; Zhou, W	1
Assumpção, ALFV; Lu, Z; Marlowe, KW; Pan, X; Shaffer, KS	1
Bi, Y; Chen, X; Cui, D; Shu, J; Xiong, X; Zhao, Y	1
Abou-Eid, S; Megger, DA; Sitek, B; Zülch, B	1
Dong, C; Jeong, LS; Jia, L; Kang, J; Li, L; Liang, Y; Liu, X; Liu, XK; Sun, S; Wang, X; Yan, Z; Yu, J; Zeng, MS; Zhang, W; Zhang, Y; Zhao, H; Zhong, Q	1
Kanka, J; Kinterova, V; Petruskova, V; Toralova, T	1
Guo, H; Hong, X; Li, S; Li, W; Wei, W; Wei, Z; Xie, M; Zhang, S	1
Bai, N; Bai, ZG; Hu, L; Ma, XM; Zhang, ZT	1
Funato, K; Ishibashi, R; Kishikawa, T; Koike, K; Ohno, M; Otsuka, M; Seimiya, T; Sekiba, K; Suzuki, T; Tanaka, E; Yamagami, M	1
Huang, KY; Huang, TJ; Kuan, FC; Kuo, KL; Lee, CY; Lin, WC; Liu, SH; Shi, CS; Tang, CH; Wu, MH	1
Cao, C; Fan, S; Guan, MX; Jin, H; Li, H; Li, Y; Meng, F; Sun, Y; Tan, M; Zhao, L; Zhou, Q; Zhu, L	1
Chen, L; He, S; Hu, X; Jeong, LS; Jia, L; Jia, X; Li, C; Li, L; Liu, G; Liu, X; Lu, Y; Ni, S; Shao, ZM; Sun, H; Yu, J; Yu, K; Zhang, J; Zhang, W; Zhang, Y; Zhao, H; Zhou, L	1
Bauer, TM; Faessel, H; Faller, DV; Harvey, RD; Lockhart, AC; Nemunaitis, J; Sedarati, F; Venkatakrishnan, K; Zhou, X	1
Hu, Q; Liu, M; Liu, Y; Shang, Q; Xue, Y; Yin, L; Zhu, H	1
Brands, RC; El-Mesery, M; Hartmann, S; Kübler, AC; Müller-Richter, UDA; Scheurer, MJJ; Seher, A	1
Hao, R; Li, R; Li, X; Qian, F; Song, Y; Sun, L; Wu, Y; Yang, X; Ye, RD	1
Kim, IM; Li, J; Littlejohn, R; Liu, J; Ma, W; Stansfield, BK; Su, H; Weintraub, NL; Zhou, J; Zou, J	1
Jia, L; Jiang, Y; Li, L; Luo, Q; Zhou, L	1
Gambus, A; Jones, RM; Poovathumkadavil, D; Priego Moreno, S; Scaramuzza, S	1
Bie, P; Fang, L; Jiang, P; Li, G; Lin, X; Wu, D; Xie, CM; Yang, Z; Yin, L; Zhang, J; Zhang, L; Zhong, C	1
Chen, C; Ma, Y; Wang, W; Wang, X; Yang, R; Yang, Z; Zhang, Q; Zhao, K; Zhao, X; Zhou, S	1
Chung, D; Dellaire, G; Salsman, J	1
Fan, S; Huang, T; Jia, J; Jin, Y; Li, M; Li, Y; Liang, X; Ma, T; Tan, Z; Yang, M	1
Cheng, W; Hoffman, RM; Jeong, LS; Jia, L; Jiang, Y; Li, L; Liang, Y; Qi, H; Yang, X; Yu, J; Zheng, P; Zhou, L	1
Hordijk, PL; Jim, KK; Kovačević, I; Majolée, J; Pronk, MCA; van Bezu, JSM; van der Sar, AM	1
Li, C; Liang, Y; Liu, Z; Xie, L; Yu, S	1
Cai, L; Chen, G; Jia, L; Jiang, Y; Kang, J; Li, L; Liang, Y; Liu, X; Ruan, H; Wang, M; Wang, S; Zhang, W; Zhang, Y	1
Guo, DF; Rahmouni, K	1
Liu, X; Ouyang, G; Tang, J; Xiao, W; Xu, C; Yu, G	1
Bi, R; Deng, Y; Guo, H; Li, Y; Shen, S; Wang, C; Wei, W; Yang, Y; Yu, XF; Zhang, N; Zheng, W	1
Bahjat, M; Bende, RJ; Bloedjes, T; de Wilde, G; Eldering, E; Guikema, JEJ; Kersten, MJ; Luijks, DM; Maas, C; van Dam, T; van Noesel, CJM	1
Faessel, HM; Faller, DV; Mould, DR; Sedarati, F; Venkatakrishnan, K; Zhou, X	1
Ehrenschwender, M; El-Mesery, M; Leich, E; Rauert-Wunderlich, H; Rosenthal, T; Schlosser, A; Schreder, M; Siegmund, D; Stühmer, T; Wajant, H	1
Andersson-Sand, H; Caramuta, S; Fotouhi, O; Ghaderi, M; Juhlin, CC; Kharaziha, P; Kjellin, H; Kjellman, M; Larsson, C; Orre, LM; Pan, Y; Vesterlund, M; Yousef, A; Zedenius, J	1
Chen, Y; Guy, RK; Hammill, JT; Kim, HS; Min, J; Rector, J; Schulman, BA; Scott, DC; Singh, B	1
Chen, G; Li, H; Schiff, R; Sun, Y; Tan, M; Xie, CM; Xiong, X; Yin, Y	1
Hosono, N	1
Assumpção, ALFV; Huelsmeyer, MK; Jia, S; Lu, Z; Pan, X; Vail, DM; Van Hesteren, MA; Wood, EA	1
Cai, L; Jia, L; Li, L; Liu, L	1
Boag, G; Chinner, N; Fernandes, K; Garg, AK; Hepburn, LA; Ibrahim, AFM; Leigh, IM; McHugh, A; Proby, CM; Saville, MK	1
Sun, Y; Zhang, S	1
Ding, Z; Ejendal, KFK; Hayes, MP; Larsen, MJ; Santoro, N; Soto-Velasquez, M; Watts, VJ	1
Jia, L; Zhou, L	1
Mao, H; Sun, Y	1
Chen, G; Chen, W; Cheng, W; Hoffman, RM; Ji, G; Jia, L; Jiang, Y; Li, L; Liang, Y; Wang, M; Wang, S; Zhang, W; Zhang, Y; Zhao, H; Zhou, L; Zhou, W	1
Chen, ZS; Fan, YF; Li, JS; Ma, XY; Wei, LY; Wu, ZX; Yang, DH; Yang, Y; Zhao, M	1
Broaddus, R; Dai, H; Garnett, J; Hu, L; Jonasch, E; Kopetz, S; Lam, TNA; Li, Y; Liang, Y; Lin, SY; Lu, KH; McGrail, DJ; Menter, D; Mills, GB; Peng, G; Sahni, N; Schmandt, R; Shih, DJH; Sun, C; Wu, JY; Yates, MS; Yin, J	1
Feng, FY; Han, S; Liu, X; Sun, GY; Sun, Y; Tan, M; Wang, G; Wilder-Romans, K; Zhou, X; Zhu, H	1
Dai, Y; Hao, Y; Li, C; Liu, L; Pan, Y; Sun, X; Tong, X; Zhang, S; Zhang, T; Zhang, Y	1
Berger, A; Best, S; Bruss, N; Danilov, AV; Danilova, OV; Kittai, A; Lam, V; Lind, EF; Liu, T; Murray, S; Pennock, ND	1
Huibregtse, JM; Matouschek, A; Tomita, T	1
Chen, Y; Du, M; Liu, W; Tan, Y; Xie, P; Yusuying, S	1
Cai, L; Chen, P; Heng, Y; Jia, L; Jiang, Y; Jin, X; Li, L; Liang, Y; Zhang, W	1
Heo, MJ; Jeong, LS; Jung, J; Kang, SH; Kim, HR; Kim, KM; Kim, SG; Kim, YS; Lee, JM; Lim, H; Moon, A; Yu, J	1
He, S; Rao, F; Shi, S; Su, Y; Wu, J; Yang, X; Zhang, J; Zhang, X	1
Cordes, BA; Iempridee, T; Kraus, RJ; Lambert, PF; Lee, DL; Mertz, JE; Patel, P; Sathiamoorthi, S; Yu, X; Yuan, X	1
Anany, MA; El-Mesery, M; Hazem, SH; Shaker, ME	1
Dutta, R; Jeng, MY; Mannis, GN; Tan, IT; Zhang, TY	1
Adhya, AK; Jiramongkol, Y; Lam, EW; Mishra, SK; Naik, SK; Parida, DK; Parija, M; Prakash, S	1
Guo, H; Liu, Y; Lou, G; Sun, Y; Xie, M; Yang, Z; Yao, J; Zheng, M	1
Chester, JA; Ding, Z; Knipp, GT; van Rijn, RM; Watts, VJ	1
Kroonen, JS; Vertegaal, ACO	1
Adès, L; Bell, J; Campelo, MD; Cerrano, M; Faller, DV; Fram, RJ; Friedlander, S; Graux, C; Liesveld, J; Lopez, PF; Radinoff, A; Sangerman, MA; Sekeres, MA; Selleslag, D; Tzvetkov, N; Watts, J; Zeidner, JF; Zhao, D	1
Bowen, S; Dai, Y; Faller, DV; Friedlander, S; Haikawa, K; Hua, Z; Kupperman, E; Kuroda, S; Nakai, K; Sedarati, F; Venkatakrishnan, K; Yamamoto, Y; Yuan, Y; Zhou, X	1
Augoff, K; Hryniewicz-Jankowska, A; Sossey-Alaoui, K; Stach, K; Tabola, R; Wierzbicki, J	1
Chen, Y; Feng, W; Hua, R; Huo, Y; Jiang, H; Lin, Y; Yang, X; Yin, B; Zhang, J	1
Bouchal, J; Gachechiladze, M; Kharaishvili, G; Kral, M; Kurfurstova, D; Mickova, A; Mistrik, M; Pokryvkova, B; Soucek, K; Vacek, O	1
Huber, RJ; Kim, WD; Mathavarajah, S	1
Arrate, MP; Boghaert, ER; Cojocari, D; Gorska, A; Hogdal, LJ; Huska, JD; Phillips, DC; Purkal, JJ; Ramsey, HE; Savona, MR; Smith, BN; Xiao, Y	1
Bravo-Navas, S; Briz, M; Domínguez-García, JJ; Pipaón, C; Romón, Í; Yáñez, L	1
Augert, A; Basom, R; Eastwood, E; MacPherson, D; Norton, JP; Rudin, CM	1
Bei, Q; Liu, H; Luo, X	1
Aladjem, MI; Baris, AM; Fu, H; Gross, JM; Jang, SM; Lazar, SB; Marks, AB; Mencer, ST; Mosavarpour, S; Pongor, LS; Rao, M; Redon, CE; Sebastian, R; Thakur, BL; Utani, K; Zhuang, SZ	1
Barbieri, E; Foster, JH; Horton, TM; Moreno-Smith, M; Scorsone, KA; Zage, P; Zhang, L	1
Aspichueta, P; Azkargorta, M; Banales, JM; Bujanda, L; Caballero-Camino, FJ; Drenth, JPH; Elortza, F; Izquierdo-Sanchez, L; Lee-Law, PY; Martinez-Chantar, ML; Marzioni, M; Olaizola, P; Perugorria, MJ; Rodrigues, PM	1
Ji, X; Tu, Y; Wang, K; Wang, X; Xie, L; Zeng, X; Zhang, J; Zhu, L; Zhu, M	1
Ayyildiz, D; Calandrini, C; de Heus, C; de Krijger, RR; Derakhshan, S; Dolman, MEM; Drost, J; Kool, M; Langenberg, KPS; Liv, N; Molenaar, JJ; Paassen, I; Tytgat, GAM; van de Ven, M; van den Heuvel-Eibrink, MM; van Hooff, SR	1
Flores-Martínez, YA; Le-Trilling, VTK; Trilling, M	1
Liu, X; Reichermeier, KM; Wang, K	1
El-Far, YM; El-Mesery, M	1
Antonangeli, F; Capuano, C; Cippitelli, M; Fionda, C; Galandrini, R; Mekhloufi, A; Molfetta, R; Paolini, R; Petillo, S; Petrucci, MT; Pighi, C; Santoni, A; Soriani, A; Zingoni, A	1
Celik, H; Challen, GA; Collins, TB; De Togni, ES; Fisher, DAC; Fulbright, MC; Kong, T; Laranjeira, ABA; Oh, ST; Ruzinova, M; Wong, AJ	1
Abounouh, K; Altawalah, H; Benjelloun, S; Dehbi, H; Ezzikouri, S; Kayesh, MEH; Kitab, B; Kohara, M; Murakami, S; Ogawa, S; Pineau, P; Tanaka, Y; Tsukiyama-Kohara, K	1
Agelopoulos, K; Berdel, WE; Göllner, S; Klosner, J; Müller-Tidow, C; Rohde, C; Schliemann, C	1
Kuang, T; Li, JA; Lou, W; Mao, W; Rong, Y; Zhang, L	1
Cao, Y; Chang, L; Fan, W; Geng, X; Hu, Y; Kang, L; Liu, Z; Luo, H; Ran, Y; Shi, MJ; Wang, R; Wang, S; Yang, H; Yang, X; Yin, X; Yu, H; Zhao, BQ; Zhong, Y; Zhu, Y	1
Chen, C; Clayton, YD; Friedman, JE; Gu, L; Hasan, MN; Li, T; Matye, DJ; Wang, Y	1
Berens, ME; Bybee, R; Dhruv, HD; Ferdosi, SR; Furnari, F; Garcia-Mansfield, K; Hartman, L; Lee, M; Ma, J; Parisian, AD; Peng, S; Pirrotte, P; Reid, G; Sharma, R; Tang, N; Taylor, B	1
Dolan, BP; Gibbs, JS; Leestemaker-Palmer, AL; Vijayasimha, K; Yewdell, JW	1
Adès, L; Anagnostopoulos, A; De Paz Arias, R; Díez-Campelo, M; Doronin, VA; Faller, DV; Fram, RJ; Friedlander, S; Girshova, L; Kambhampati, S; Munhoz, EC; Platzbecker, U; Santini, V; Sekeres, MA; Symeonidis, A; Valcárcel, D; Viniou, NA; Woszczyk, D; Yuan, Y	1
Cheng, SY; Goenka, A	1
Liu, Y; Ma, L; Meng, L; Xiong, H; Yang, Z; Zheng, D	1
Chen, Q; Dou, L; Li, H; Meredith, MA; Sun, Y; Xiong, X; Xu, T; You, X; Zhang, S	1
Chen, W; Wang, Y; Xia, W; Zhang, J; Zhao, Y	1
Hou, T; Li, Y; Li, Z; Liu, H; Ma, Q; Pan, P; Sun, Y; Xiong, X; Xu, T; Yu, B; Yu, Q; Zheng, Y	1
Arellano, ML; Baer, MR; Ball, BJ; Blum, W; Borate, U; Boyiadzis, MM; Burd, A; Byrd, JC; Chen, T; Collins, RH; Deininger, M; Druker, BJ; Duong, VH; Foran, JM; Foster, MC; Gana, TJ; Heerema, NA; Kaufmann, SH; Kovacsovics, T; Levine, RL; Lin, TL; Litzow, MR; Marcus, S; Martycz, M; Mims, AS; Odenike, O; Olin, RL; Patel, PA; Peterson, KL; Rosenberg, L; Saliba, AN; Schiller, GJ; Schneider, PA; Shoben, AB; Stefanos, M; Stein, EM; Stock, W; Traer, E; Walker, A; Yocum, AO	1
Berger, A; Chen, C; Danilov, AV; Hernandez-Ilizaliturri, F; Kambhampati, S; Lam, V; Pennock, N; Rodriguez-Rodriguez, S; Roleder, C; Siddiqi, T; Torka, P; Vuong, D; Wang, JH; Wang, L; Wang, X; Xia, Z	1
Aladjem, MI; Ceribelli, M; Fu, H; Jo, U; Murai, J; Murai, Y; Pommier, Y; Redon, CE; Thomas, CJ	1
Aubry, A; Avet-Loiseau, H; Bremner, R; Charish, J; Corre, J; Monnier, PP; Pearson, JD; Sivak, JM; Xirodimas, DP; Yu, T	1
Guo, ZS	1

Reviews

13 review(s) available for cyclopentane and pevonedistat

Article	Year
Novel roles of Skp2 E3 ligase in cellular senescence, cancer progression, and metastasis. Chinese journal of cancer, 2012, Volume: 31, Issue:4 Topics: Animals; Cell Movement; Cellular Senescence; Cyclopentanes; Disease Progression; Drug Delivery Systems; Gene Expression Regulation, Neoplastic; Humans; Neoplasms; Pyrimidines; S-Phase Kinase-Associated Proteins; Ubiquitination	2012
Inhibition of NEDD8-conjugation pathway by novel molecules: potential approaches to anticancer therapy. Molecular oncology, 2012, Volume: 6, Issue:3 Topics: Animals; Cyclopentanes; Humans; NEDD8 Protein; Neoplasms; Pyrimidines; Signal Transduction; SKP Cullin F-Box Protein Ligases; Ubiquitins	2012
MLN4924: a novel first-in-class inhibitor of NEDD8-activating enzyme for cancer therapy. Expert opinion on investigational drugs, 2012, Volume: 21, Issue:10 Topics: Animals; Antineoplastic Agents; Cyclopentanes; Humans; NEDD8 Protein; Neoplasms; Pyrimidines; Ubiquitins	2012
Negative regulation of NEDD8 conjugation pathway by novel molecules and agents for anticancer therapy. Current pharmaceutical design, 2013, Volume: 19, Issue:22 Topics: Antineoplastic Agents; Cyclopentanes; Humans; NEDD8 Protein; Neoplasms; Proteasome Endopeptidase Complex; Pyrimidines; Ubiquitins	2013
Neddylation Pathway as a Novel Anti-cancer Target: Mechanistic Investigation and Therapeutic Implication. Anti-cancer agents in medicinal chemistry, 2015, Volume: 15, Issue:9 Topics: Antineoplastic Agents; Cyclopentanes; Humans; Macrophages; NEDD8 Protein; Neoplasms; Neovascularization, Pathologic; Pyrimidines; Ubiquitins	2015
MLN4924 therapy as a novel approach in cancer treatment modalities. Journal of chemotherapy (Florence, Italy), 2016, Volume: 28, Issue:2 Topics: Antineoplastic Agents; Apoptosis; Autophagy; Cell Cycle Proteins; Cullin Proteins; Cyclopentanes; Humans; Neoplasms; NF-KappaB Inhibitor alpha; Proto-Oncogene Proteins c-bcl-2; Pyrimidines; Radiation-Sensitizing Agents	2016
Protein neddylation and its alterations in human cancers for targeted therapy. Cellular signalling, 2018, Volume: 44 Topics: Apoptosis; Autophagy; Cell Cycle Checkpoints; Cellular Senescence; Cyclopentanes; Humans; Molecular Targeted Therapy; Neoplasms; Protein Processing, Post-Translational; Pyrimidines; Ubiquitin-Activating Enzymes; Ubiquitin-Protein Ligases	2018
Pharmaceutical Inhibition of Neddylation as Promising Treatments for Various Cancers. Current topics in medicinal chemistry, 2019, Volume: 19, Issue:12 Topics: Antineoplastic Agents; Biological Products; Cyclopentanes; Epigenesis, Genetic; Humans; NEDD8 Protein; Neoplasms; Protein Processing, Post-Translational; Pyrimidines	2019
Neddylation: a novel modulator of the tumor microenvironment. Molecular cancer, 2019, 04-03, Volume: 18, Issue:1 Topics: Cancer-Associated Fibroblasts; Cell Survival; Cellular Senescence; Clinical Trials as Topic; Cyclopentanes; Humans; NEDD8 Protein; Neoplasms; Pyrimidines; Signal Transduction; Tumor Microenvironment	2019
[New therapeutic agents for acute myeloid leukemia]. [Rinsho ketsueki] The Japanese journal of clinical hematology, 2019, Volume: 60, Issue:9 Topics: Benzimidazoles; Bridged Bicyclo Compounds, Heterocyclic; Cyclopentanes; Drug Approval; Flavonoids; Glycine; Humans; Leukemia, Myeloid, Acute; Molecular Targeted Therapy; Phenylurea Compounds; Piperidines; Pyridines; Pyrimidines; Sulfonamides; United States; United States Food and Drug Administration	2019
Targeting Protein Neddylation for Cancer Therapy. Advances in experimental medicine and biology, 2020, Volume: 1217 Topics: Animals; Apoptosis; Autophagy; Cyclopentanes; Humans; NEDD8 Protein; Neoplasms; Pyrimidines; Ubiquitin-Protein Ligases; Ubiquitination	2020
Neddylation-Independent Activities of MLN4924. Advances in experimental medicine and biology, 2020, Volume: 1217 Topics: Animals; Antineoplastic Agents; Apoptosis; Carrier Proteins; Cyclopentanes; ErbB Receptors; Glycolysis; Humans; Interferon-beta; Membrane Proteins; NEDD8 Protein; Pneumonia; Pyrimidines; Thyroid Hormone-Binding Proteins; Thyroid Hormones	2020
Targeting SUMO Signaling to Wrestle Cancer. Trends in cancer, 2021, Volume: 7, Issue:6 Topics: Antineoplastic Agents; Cell Cycle; Cell Proliferation; Clinical Trials as Topic; Cyclopentanes; Gene Expression Regulation, Neoplastic; Humans; NEDD8 Protein; Neoplasms; Pyrazoles; Pyrimidines; Signal Transduction; Small Ubiquitin-Related Modifier Proteins; Sulfides; Sulfonamides; Sumoylation; Ubiquitin-Activating Enzymes	2021

Trials

11 trial(s) available for cyclopentane and pevonedistat

Article	Year
Pevonedistat (MLN4924), a First-in-Class NEDD8-activating enzyme inhibitor, in patients with acute myeloid leukaemia and myelodysplastic syndromes: a phase 1 study. British journal of haematology, 2015, Volume: 169, Issue:4 Topics: Adult; Aged; Aged, 80 and over; Chemical and Drug Induced Liver Injury; Cyclopentanes; Enzyme Inhibitors; Female; Humans; Leukemia, Myeloid, Acute; Male; Maximum Tolerated Dose; Middle Aged; Multiple Organ Failure; Myelodysplastic Syndromes; Pyrimidines; Ubiquitin-Activating Enzymes	2015
Phase I Study of the Investigational NEDD8-Activating Enzyme Inhibitor Pevonedistat (TAK-924/MLN4924) in Patients with Advanced Solid Tumors. Clinical cancer research : an official journal of the American Association for Cancer Research, 2016, Feb-15, Volume: 22, Issue:4 Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Cyclopentanes; Female; Humans; Male; Maximum Tolerated Dose; Middle Aged; Neoplasms; Pyrimidines; Treatment Outcome; Tumor Burden; Ubiquitin-Activating Enzymes	2016
Phase I Study of the Novel Investigational NEDD8-Activating Enzyme Inhibitor Pevonedistat (MLN4924) in Patients with Relapsed/Refractory Multiple Myeloma or Lymphoma. Clinical cancer research : an official journal of the American Association for Cancer Research, 2016, Jan-01, Volume: 22, Issue:1 Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Biomarkers; Cyclopentanes; Drug Administration Schedule; Drug Monitoring; Drug Resistance, Neoplasm; Female; Humans; Lymphoma; Male; Maximum Tolerated Dose; Middle Aged; Molecular Targeted Therapy; Multiple Myeloma; NEDD8 Protein; Neoplasm Recurrence, Local; Pyrimidines; Retreatment; Treatment Outcome; Ubiquitins	2016
A phase I study of the investigational NEDD8-activating enzyme inhibitor pevonedistat (TAK-924/MLN4924) in patients with metastatic melanoma. Investigational new drugs, 2016, Volume: 34, Issue:4 Topics: Adult; Aged; Cyclopentanes; Female; Humans; Male; Maximum Tolerated Dose; Melanoma; Middle Aged; Pyrimidines; Treatment Outcome; Ubiquitin-Activating Enzymes	2016
Expanded safety analysis of pevonedistat, a first-in-class NEDD8-activating enzyme inhibitor, in patients with acute myeloid leukemia and myelodysplastic syndromes. Blood cancer journal, 2017, 02-03, Volume: 7, Issue:2 Topics: Adult; Aged; Aged, 80 and over; Cyclopentanes; Enzyme Inhibitors; Female; Humans; Leukemia, Myeloid, Acute; Male; Maximum Tolerated Dose; Middle Aged; Myelodysplastic Syndromes; NEDD8 Protein; Pyrimidines; Young Adult	2017
Effect of CYP3A inhibitors on the pharmacokinetics of pevonedistat in patients with advanced solid tumours. British journal of clinical pharmacology, 2019, Volume: 85, Issue:7 Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Area Under Curve; Carboplatin; Cyclopentanes; Cytochrome P-450 CYP3A Inhibitors; Docetaxel; Drug Interactions; Enzyme Inhibitors; Female; Fluconazole; Humans; Itraconazole; Male; Middle Aged; Neoplasms; Paclitaxel; Pyrimidines	2019
Improved outcomes of octogenarians and nonagenarians with acute myeloid leukemia in the era of novel therapies. American journal of hematology, 2020, Volume: 95, Issue:11 Topics: Aged, 80 and over; Aniline Compounds; Antibodies, Monoclonal, Humanized; Antineoplastic Combined Chemotherapy Protocols; Bridged Bicyclo Compounds, Heterocyclic; Cyclopentanes; Disease-Free Survival; Female; Glycine; Humans; Leukemia, Myeloid, Acute; Male; Pyrazines; Pyridines; Pyrimidines; Retrospective Studies; Sulfonamides; Survival Rate	2020
Randomized phase 2 trial of pevonedistat plus azacitidine versus azacitidine for higher-risk MDS/CMML or low-blast AML. Leukemia, 2021, Volume: 35, Issue:7 Topics: Antimetabolites, Antineoplastic; Azacitidine; Cyclopentanes; Enzyme Inhibitors; Humans; Leukemia, Myeloid, Acute; Leukemia, Myelomonocytic, Chronic; Myelodysplastic Syndromes; Pyrimidines	2021
Asia-inclusive global development of pevonedistat: Clinical pharmacology and translational research enabling a phase 3 multiregional clinical trial. Clinical and translational science, 2021, Volume: 14, Issue:3 Topics: Antineoplastic Combined Chemotherapy Protocols; Asia; Azacitidine; Cyclopentanes; Drugs, Investigational; Global Burden of Disease; Humans; Incidence; International Cooperation; Leukemia, Myeloid, Acute; Leukemia, Myelomonocytic, Chronic; Maximum Tolerated Dose; Myelodysplastic Syndromes; Pharmacology, Clinical; Pyrimidines; Translational Research, Biomedical; Ubiquitin-Activating Enzymes; United States	2021
Pevonedistat plus azacitidine vs azacitidine alone in higher-risk MDS/chronic myelomonocytic leukemia or low-blast-percentage AML. Blood advances, 2022, 09-13, Volume: 6, Issue:17 Topics: Antimetabolites, Antineoplastic; Azacitidine; Cyclopentanes; Drug Therapy, Combination; Humans; Leukemia, Myelomonocytic, Chronic; Pyrimidines	2022
Pevonedistat with azacitidine in older patients with TP53-mutated AML: a phase 2 study with laboratory correlates. Blood advances, 2023, 06-13, Volume: 7, Issue:11 Topics: Aged; Azacitidine; Cyclopentanes; Humans; Leukemia, Myeloid, Acute; Pyrimidines; Tumor Suppressor Protein p53	2023

Other Studies

241 other study(ies) available for cyclopentane and pevonedistat

Article	Year
An inhibitor of NEDD8-activating enzyme as a new approach to treat cancer. Nature, 2009, Apr-09, Volume: 458, Issue:7239 Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Cells, Cultured; Cullin Proteins; Cyclopentanes; Enzyme Inhibitors; Female; Humans; Mice; NEDD8 Protein; Neoplasms; Proteasome Inhibitors; Pyrimidines; Transplantation, Heterologous; Ubiquitin-Activating Enzymes; Ubiquitins	2009
Targeting NEDD8-activated cullin-RING ligases for the treatment of cancer. Clinical cancer research : an official journal of the American Association for Cancer Research, 2009, Jun-15, Volume: 15, Issue:12 Topics: Antineoplastic Agents; Boronic Acids; Bortezomib; Cullin Proteins; Cyclopentanes; Humans; NEDD8 Protein; Neoplasms; NF-kappa B; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Pyrazines; Pyrimidines; RING Finger Domains; Signal Transduction; Ubiquitin-Activating Enzymes; Ubiquitin-Conjugating Enzymes; Ubiquitin-Protein Ligases; Ubiquitins	2009
Substrate-assisted inhibition of ubiquitin-like protein-activating enzymes: the NEDD8 E1 inhibitor MLN4924 forms a NEDD8-AMP mimetic in situ. Molecular cell, 2010, Jan-15, Volume: 37, Issue:1 Topics: Adenosine Monophosphate; Binding Sites; Binding, Competitive; Cell Line, Tumor; Crystallography, X-Ray; Cyclopentanes; Enzyme Activation; Enzyme Inhibitors; Humans; NEDD8 Protein; Protein Structure, Tertiary; Pyrimidines; Ubiquitins	2010
Inhibition of NEDD8-activating enzyme: a novel approach for the treatment of acute myeloid leukemia. Blood, 2010, May-06, Volume: 115, Issue:18 Topics: Animals; Blotting, Western; Cell Line, Tumor; Cullin Proteins; Cyclopentanes; DNA Damage; Fluorescent Antibody Technique; fms-Like Tyrosine Kinase 3; Humans; Leukemia, Myeloid, Acute; Mice; NEDD8 Protein; NF-kappa B; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Pyrimidines; Reactive Oxygen Species; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Signal Transduction; Ubiquitins; Xenograft Model Antitumor Assays	2010
SUMO, Ubiquitin, UBL Proteins: Implications For Human Diseases - Fifth International Conference. IDrugs : the investigational drugs journal, 2010, Volume: 13, Issue:4 Topics: Allosteric Regulation; Bacterial Toxins; Communicable Diseases; Cyclopentanes; Cytokines; Enzyme Activation; Enzyme Inhibitors; Gene Expression Regulation; Heat-Shock Proteins; Hemolysin Proteins; Heterocyclic Compounds, 3-Ring; Humans; NEDD8 Protein; Neoplasms; Nuclear Proteins; Protein Processing, Post-Translational; Pyrimidines; Signal Transduction; Small Ubiquitin-Related Modifier Proteins; Tankyrases; Transcription Factors; Ubiquitin; Ubiquitin-Activating Enzymes; Ubiquitin-Conjugating Enzymes; Ubiquitin-Protein Ligases; Ubiquitination; Ubiquitins	2010
MLN4924, a NEDD8-activating enzyme inhibitor, is active in diffuse large B-cell lymphoma models: rationale for treatment of NF-{kappa}B-dependent lymphoma. Blood, 2010, Sep-02, Volume: 116, Issue:9 Topics: Animals; Apoptosis; B-Lymphocytes; Blotting, Western; Cell Cycle; Cell Proliferation; Cyclopentanes; DNA Replication; Female; Flow Cytometry; Germinal Center; Humans; Lymphoma, Large B-Cell, Diffuse; Mice; Mice, Inbred NOD; Mice, SCID; NEDD8 Protein; NF-kappa B; Pyrimidines; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Ubiquitins; Xenograft Model Antitumor Assays	2010
Biochemical and cellular effects of inhibiting Nedd8 conjugation. Biochemical and biophysical research communications, 2010, Jul-30, Volume: 398, Issue:3 Topics: Actins; Cell Line; Cullin Proteins; Cyclopentanes; Cytoskeleton; HeLa Cells; Humans; NEDD8 Protein; Pyrimidines; rhoA GTP-Binding Protein; RNA, Small Interfering; Ubiquitin-Conjugating Enzymes; Ubiquitins	2010
Dynamics of cullin-RING ubiquitin ligase network revealed by systematic quantitative proteomics. Cell, 2010, Dec-10, Volume: 143, Issue:6 Topics: Cell Line; Cullin Proteins; Cyclopentanes; NEDD8 Protein; Protein Processing, Post-Translational; Proteomics; Pyrimidines; Transcription Factors; Ubiquitins	2010
NEDD8-targeting drug MLN4924 elicits DNA rereplication by stabilizing Cdt1 in S phase, triggering checkpoint activation, apoptosis, and senescence in cancer cells. Cancer research, 2010, Dec-15, Volume: 70, Issue:24 Topics: Apoptosis; Cell Cycle Proteins; Cellular Senescence; Colorectal Neoplasms; Cyclin-Dependent Kinase Inhibitor p21; Cyclopentanes; DNA Replication; HCT116 Cells; Humans; Molecular Targeted Therapy; NEDD8 Protein; Pyrimidines; S Phase; Tumor Suppressor Protein p53; Ubiquitin-Protein Ligases; Ubiquitins	2010
The steady-state repertoire of human SCF ubiquitin ligase complexes does not require ongoing Nedd8 conjugation. Molecular & cellular proteomics : MCP, 2011, Volume: 10, Issue:5 Topics: Cullin Proteins; Cyclopentanes; F-Box Proteins; HEK293 Cells; Humans; Isotope Labeling; NEDD8 Protein; Protein Binding; Proteome; Pyrimidines; Recombinant Proteins; SKP Cullin F-Box Protein Ligases; Transcription Factors; Ubiquitins	2011
A natural product-like inhibitor of NEDD8-activating enzyme. Chemical communications (Cambridge, England), 2011, Mar-07, Volume: 47, Issue:9 Topics: Apigenin; Biflavonoids; Binding Sites; Cell Line, Tumor; Computer Simulation; Cyclopentanes; Drug Design; Humans; NEDD8 Protein; Pyrimidines; Ubiquitins	2011
Stereoselective synthesis of MLN4924, an inhibitor of NEDD8-activating enzyme. The Journal of organic chemistry, 2011, May-06, Volume: 76, Issue:9 Topics: Cyclopentanes; Pyrimidines; Stereoisomerism; Substrate Specificity; Ubiquitins	2011
Inhibition of NEDD8-activating enzyme induces rereplication and apoptosis in human tumor cells consistent with deregulating CDT1 turnover. Cancer research, 2011, Apr-15, Volume: 71, Issue:8 Topics: Apoptosis; Cell Cycle Proteins; Cell Line, Tumor; Cullin Proteins; Cyclopentanes; DNA Damage; DNA Replication; DNA, Neoplasm; Gene Knockdown Techniques; HCT116 Cells; Humans; NEDD8 Protein; Pyrimidines; RNA, Small Interfering; S Phase; Ubiquitins	2011
MLN4924 is an efficient inhibitor of NEDD8 conjugation in plants. Plant physiology, 2011, Volume: 156, Issue:2 Topics: Amino Acid Sequence; Arabidopsis; Arabidopsis Proteins; Cullin Proteins; Cyclopentanes; Humans; Indoleacetic Acids; Molecular Sequence Data; Morphogenesis; Mutation; Phenotype; Protein Processing, Post-Translational; Pyrimidines; Seedlings; Sequence Homology, Amino Acid; Species Specificity; Ubiquitin-Protein Ligases; Ubiquitins	2011
Induction of p21-dependent senescence by an NAE inhibitor, MLN4924, as a mechanism of growth suppression. Neoplasia (New York, N.Y.), 2011, Volume: 13, Issue:6 Topics: Animals; Apoptosis; Cell Line, Tumor; Cell Proliferation; Cell Survival; Cells, Cultured; Cellular Senescence; Cyclin-Dependent Kinase Inhibitor p21; Cyclopentanes; DNA Damage; Dose-Response Relationship, Drug; Embryo, Mammalian; Enzyme Inhibitors; Fibroblasts; HCT116 Cells; Humans; Immunoblotting; Mice; Mice, Knockout; NEDD8 Protein; Pyrimidines; SKP Cullin F-Box Protein Ligases; Ubiquitin-Activating Enzymes; Ubiquitins	2011
SCF(FBXO22) regulates histone H3 lysine 9 and 36 methylation levels by targeting histone demethylase KDM4A for ubiquitin-mediated proteasomal degradation. Molecular and cellular biology, 2011, Volume: 31, Issue:18 Topics: Basic Helix-Loop-Helix Transcription Factors; Boronic Acids; Bortezomib; Cell Cycle; Cell Cycle Proteins; Cell Line, Tumor; Chromatin; Cyclopentanes; Epigenesis, Genetic; F-Box Proteins; Gene Expression Regulation; HEK293 Cells; HeLa Cells; Histone Demethylases; Histones; Humans; Jumonji Domain-Containing Histone Demethylases; Mass Spectrometry; Methylation; Proteasome Endopeptidase Complex; Protein Processing, Post-Translational; Pyrazines; Pyrimidines; Receptors, Cytoplasmic and Nuclear; Reverse Transcriptase Polymerase Chain Reaction; RNA Interference; RNA, Small Interfering; Signal Transduction; Ubiquitination	2011
Quantitative proteomic analysis of cellular protein modulation upon inhibition of the NEDD8-activating enzyme by MLN4924. Molecular & cellular proteomics : MCP, 2011, Volume: 10, Issue:11 Topics: Cell Line, Tumor; Cyclopentanes; Gene Expression Profiling; Gene Expression Regulation; Gene Knockdown Techniques; Humans; Kinetics; Phenotype; Proteasome Endopeptidase Complex; Protein Stability; Proteolysis; Proteome; Proteomics; Pyrimidines; RNA Interference; Ubiquitin-Activating Enzymes; Ubiquitination	2011
The NEDD8-activating enzyme inhibitor, MLN4924, cooperates with TRAIL to augment apoptosis through facilitating c-FLIP degradation in head and neck cancer cells. Molecular cancer therapeutics, 2011, Volume: 10, Issue:12 Topics: Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Carcinoma, Squamous Cell; CASP8 and FADD-Like Apoptosis Regulating Protein; Cyclopentanes; DNA-Binding Proteins; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Drug Synergism; Head and Neck Neoplasms; Humans; Proteolysis; Pyrimidines; Squamous Cell Carcinoma of Head and Neck; TNF-Related Apoptosis-Inducing Ligand; Tumor Cells, Cultured; Ubiquitin-Activating Enzymes; Ubiquitination; Up-Regulation	2011
Global identification of modular cullin-RING ligase substrates. Cell, 2011, Oct-14, Volume: 147, Issue:2 Topics: Cyclopentanes; Enzyme Inhibitors; Genome, Human; Humans; Proteome; Pyrimidines; Ubiquitin-Protein Ligases; Ubiquitination	2011
Multimodal imaging with (18)F-FDG PET and Cerenkov luminescence imaging after MLN4924 treatment in a human lymphoma xenograft model. Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2011, Volume: 52, Issue:11 Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Cell Transformation, Neoplastic; Cyclopentanes; Female; Fluorodeoxyglucose F18; Humans; Luminescent Measurements; Lymphoma; Mice; Molecular Imaging; Positron-Emission Tomography; Pyrimidines	2011
Initial testing of the investigational NEDD8-activating enzyme inhibitor MLN4924 by the pediatric preclinical testing program. Pediatric blood & cancer, 2012, Volume: 59, Issue:2 Topics: Animals; Brain Neoplasms; Cell Line, Tumor; Cell Proliferation; Child; Cyclopentanes; Female; Humans; Mice; Mice, Inbred BALB C; Mice, Inbred NOD; Mice, SCID; NEDD8 Protein; Neuroblastoma; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Pyrimidines; Sarcoma; Tumor Cells, Cultured; Ubiquitins; Xenograft Model Antitumor Assays	2012
Characterization of MRFAP1 turnover and interactions downstream of the NEDD8 pathway. Molecular & cellular proteomics : MCP, 2012, Volume: 11, Issue:3 Topics: Animals; Carrier Proteins; Cell Nucleus; Cells, Cultured; Cullin Proteins; Cyclopentanes; Histone Acetyltransferases; Humans; Intracellular Signaling Peptides and Proteins; Male; Mice; NEDD8 Protein; Nuclear Proteins; Protein Interaction Maps; Pyrimidines; RNA, Small Interfering; Testis; Transcription Factors; Ubiquitin-Protein Ligases; Ubiquitins	2012
Radiosensitization of human pancreatic cancer cells by MLN4924, an investigational NEDD8-activating enzyme inhibitor. Cancer research, 2012, Jan-01, Volume: 72, Issue:1 Topics: Aneuploidy; Animals; Base Sequence; Cell Division; Cell Line, Tumor; Cyclopentanes; DNA Damage; Enzyme Inhibitors; Fluorescent Antibody Technique; G2 Phase; Humans; NEDD8 Protein; Pancreatic Neoplasms; Pyrimidines; Radiation Tolerance; RNA, Small Interfering; Ubiquitins; Xenograft Model Antitumor Assays	2012
Inactivation of SAG E3 ubiquitin ligase blocks embryonic stem cell differentiation and sensitizes leukemia cells to retinoid acid. PloS one, 2011, Volume: 6, Issue:11 Topics: Animals; Antineoplastic Agents; Apoptosis; Cell Differentiation; Cell Line, Tumor; Cyclopentanes; Drug Interactions; Embryonic Stem Cells; Enzyme Activation; Enzyme Inhibitors; Female; Gene Deletion; Humans; JNK Mitogen-Activated Protein Kinases; Leukemia, Myeloid, Acute; Male; Mice; Proto-Oncogene Proteins c-bcl-2; Pyrimidines; Tretinoin; Ubiquitin-Protein Ligases	2011
Inhibition of the Nedd8 system sensitizes cells to DNA interstrand cross-linking agents. Molecular cancer research : MCR, 2012, Volume: 10, Issue:3 Topics: Cell Line, Tumor; Checkpoint Kinase 1; Cross-Linking Reagents; Cyclopentanes; DNA; DNA Damage; Drug Screening Assays, Antitumor; Fanconi Anemia; Fanconi Anemia Complementation Group D2 Protein; Gene Knockdown Techniques; Humans; Models, Biological; NEDD8 Protein; Phosphorylation; Poly(ADP-ribose) Polymerase Inhibitors; Poly(ADP-ribose) Polymerases; Protein Kinases; Pyrimidines; Ubiquitination; Ubiquitins	2012
The ubiquitin E1 enzyme Ube1 mediates NEDD8 activation under diverse stress conditions. Cell cycle (Georgetown, Tex.), 2012, Mar-15, Volume: 11, Issue:6 Topics: Amino Acid Sequence; Blotting, Western; Cell Line, Tumor; Cyclopentanes; Enzyme Activation; Gene Knockdown Techniques; Humans; Leupeptins; Mass Spectrometry; Molecular Sequence Data; NEDD8 Protein; Oxidative Stress; Proteasome Endopeptidase Complex; Pyrimidines; Time Factors; Transfection; Tumor Suppressor Protein p53; Ubiquitin-Activating Enzymes; Ubiquitins	2012
Treatment-emergent mutations in NAEβ confer resistance to the NEDD8-activating enzyme inhibitor MLN4924. Cancer cell, 2012, Mar-20, Volume: 21, Issue:3 Topics: Animals; Binding Sites; Cell Line, Tumor; Clinical Trials as Topic; Cyclopentanes; Drug Resistance, Neoplasm; Enzyme Inhibitors; Female; Humans; Mice; Mice, Nude; Mutation; Pyrimidines; Rats; Rats, Nude; Tumor Cells, Cultured; Ubiquitin-Activating Enzymes; Xenograft Model Antitumor Assays	2012
The p21-dependent radiosensitization of human breast cancer cells by MLN4924, an investigational inhibitor of NEDD8 activating enzyme. PloS one, 2012, Volume: 7, Issue:3 Topics: Apoptosis; Base Sequence; Breast Neoplasms; Cell Cycle; Cell Line, Tumor; Cyclopentanes; Female; Flow Cytometry; Humans; NEDD8 Protein; Oncogene Protein p21(ras); Pyrimidines; Radiation-Sensitizing Agents; RNA, Small Interfering; Ubiquitins	2012
The Nedd8-activating enzyme inhibitor MLN4924 induces autophagy and apoptosis to suppress liver cancer cell growth. Cancer research, 2012, Jul-01, Volume: 72, Issue:13 Topics: Animals; Apoptosis; Autophagy; Base Sequence; Cyclopentanes; Humans; Liver Neoplasms; Mice; Mice, Nude; NEDD8 Protein; Pyrimidines; RNA, Small Interfering; Ubiquitins	2012
NEDD8 overexpression results in neddylation of ubiquitin substrates by the ubiquitin pathway. Journal of molecular biology, 2012, Aug-03, Volume: 421, Issue:1 Topics: Caspase 7; Cells, Cultured; Cyclopentanes; Gene Expression Regulation; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; NEDD8 Protein; Pyrimidines; Tumor Suppressor Protein p53; Ubiquitin; Ubiquitin-Activating Enzymes; Ubiquitin-Conjugating Enzymes; Ubiquitin-Protein Ligases; Ubiquitins	2012
WEE1 accumulation and deregulation of S-phase proteins mediate MLN4924 potent inhibitory effect on Ewing sarcoma cells. Oncogene, 2013, Mar-14, Volume: 32, Issue:11 Topics: Animals; Antineoplastic Agents; Bone Neoplasms; Cell Cycle Proteins; Cell Line, Tumor; Cyclopentanes; Female; Gene Expression Regulation, Neoplastic; Gene Knockdown Techniques; Humans; Mice; Mice, Inbred C57BL; Nuclear Proteins; Protein-Tyrosine Kinases; Pyrimidines; RNA, Small Interfering; S Phase; Sarcoma, Ewing; Xenograft Model Antitumor Assays	2013
A gatekeeper residue for NEDD8-activating enzyme inhibition by MLN4924. Cell reports, 2012, Apr-19, Volume: 1, Issue:4 Topics: Amino Acid Sequence; Amino Acid Substitution; Cell Line, Tumor; Chromatography, Liquid; Cullin Proteins; Cyclopentanes; Cytochrome P-450 Enzyme System; Drug Resistance, Neoplasm; HCT116 Cells; Humans; Molecular Sequence Data; Point Mutation; Pyrimidines; Sequence Alignment; Tandem Mass Spectrometry; Ubiquitin-Activating Enzymes	2012
Inactivation of the Cullin (CUL)-RING E3 ligase by the NEDD8-activating enzyme inhibitor MLN4924 triggers protective autophagy in cancer cells. Autophagy, 2012, Volume: 8, Issue:11 Topics: Animals; Autophagy; Cullin Proteins; Cyclopentanes; Cytoprotection; Enzyme Activation; Enzyme Inhibitors; Gene Knockdown Techniques; Humans; Mice; Models, Biological; Neoplasms; Pyrimidines; Reactive Oxygen Species; Ubiquitin-Protein Ligases; Ubiquitins	2012
Inhibition of neddylation represses lipopolysaccharide-induced proinflammatory cytokine production in macrophage cells. The Journal of biological chemistry, 2012, Oct-12, Volume: 287, Issue:42 Topics: Animals; Anti-Inflammatory Agents; Cell Line, Tumor; Cyclopentanes; Dexamethasone; Humans; Inflammation Mediators; Interleukin-6; Lipopolysaccharides; Macrophages; Mice; NEDD8 Protein; NF-kappa B; Protein Processing, Post-Translational; Pyrimidines; Transcription, Genetic; Tumor Necrosis Factor-alpha; Ubiquitin-Activating Enzymes; Ubiquitins; Up-Regulation	2012
Targeting Cullin-RING ligases by MLN4924 induces autophagy via modulating the HIF1-REDD1-TSC1-mTORC1-DEPTOR axis. Cell death & disease, 2012, Sep-06, Volume: 3 Topics: Autophagy; Autophagy-Related Protein 5; Cell Line, Tumor; Cyclopentanes; HCT116 Cells; HeLa Cells; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Intracellular Signaling Peptides and Proteins; MCF-7 Cells; Mechanistic Target of Rapamycin Complex 1; Microtubule-Associated Proteins; Multiprotein Complexes; Pyrimidines; RNA Interference; RNA, Small Interfering; TOR Serine-Threonine Kinases; Transcription Factors; Tuberous Sclerosis Complex 1 Protein; Tumor Suppressor Proteins; Ubiquitin-Protein Ligases	2012
Novel DNA damage checkpoints mediating cell death induced by the NEDD8-activating enzyme inhibitor MLN4924. Cancer research, 2013, Jan-01, Volume: 73, Issue:1 Topics: Antineoplastic Agents; Blotting, Western; Cell Cycle Checkpoints; Cell Line, Tumor; Cyclopentanes; DNA Damage; Flow Cytometry; Humans; Melanoma; NEDD8 Protein; Polymerase Chain Reaction; Pyrimidines; Ubiquitins	2013
A metal-based inhibitor of NEDD8-activating enzyme. PloS one, 2012, Volume: 7, Issue:11 Topics: Caco-2 Cells; Cell Line, Tumor; Cell-Free System; Cyclopentanes; Dimerization; DNA-Binding Proteins; Dose-Response Relationship, Drug; Humans; Inhibitory Concentration 50; Ligands; Luciferases; Magnetic Resonance Spectroscopy; Metals; Models, Chemical; Molecular Conformation; NEDD8 Protein; NF-kappa B; Protein Binding; Pyridines; Pyrimidines; Rhodium; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Ubiquitin-Activating Enzymes; Ubiquitins	2012
Neddylation pathway regulates T-cell function by targeting an adaptor protein Shc and a protein kinase Erk signaling. Proceedings of the National Academy of Sciences of the United States of America, 2013, Jan-08, Volume: 110, Issue:2 Topics: Adoptive Transfer; Animals; CD4-Positive T-Lymphocytes; Cell Differentiation; Cullin Proteins; Cyclopentanes; Gene Knockdown Techniques; Immunoblotting; Immunoprecipitation; MAP Kinase Signaling System; Mice; Mice, Inbred C57BL; NEDD8 Protein; Oligonucleotides; Pyrimidines; Receptors, Antigen, T-Cell; Shc Signaling Adaptor Proteins; Src Homology 2 Domain-Containing, Transforming Protein 1; Ubiquitins	2013
Inhibition of a NEDD8 Cascade Restores Restriction of HIV by APOBEC3G. PLoS pathogens, 2012, Volume: 8, Issue:12 Topics: APOBEC-3G Deaminase; Carrier Proteins; CD4-Positive T-Lymphocytes; Cell Line; Cullin Proteins; Cyclopentanes; Cytidine Deaminase; HEK293 Cells; HIV; HIV Infections; Humans; Magnetic Resonance Imaging; NEDD8 Protein; Pyrimidines; RNA Interference; RNA, Small Interfering; Ubiquitin-Protein Ligases; Ubiquitins; vif Gene Products, Human Immunodeficiency Virus	2012
H2O2 regulates lung epithelial sodium channel (ENaC) via ubiquitin-like protein Nedd8. The Journal of biological chemistry, 2013, Mar-22, Volume: 288, Issue:12 Topics: Alveolar Epithelial Cells; Animals; Cells, Cultured; Cullin Proteins; Cyclopentanes; Epithelial Sodium Channels; Female; Gene Expression; Hydrogen Peroxide; Membrane Potentials; Mice; Mice, Inbred C57BL; NEDD8 Protein; Oxidation-Reduction; Patch-Clamp Techniques; Pyrimidines; Rats; Ubiquitin-Activating Enzymes; Ubiquitin-Protein Ligases; Ubiquitination; Ubiquitins; Up-Regulation	2013
Neddylation pathway regulates the proliferation and survival of macrophages. Biochemical and biophysical research communications, 2013, Mar-15, Volume: 432, Issue:3 Topics: Animals; Apoptosis; Cell Line; Cell Proliferation; Cell Survival; Cyclopentanes; Cytokines; DNA Damage; G2 Phase Cell Cycle Checkpoints; Macrophages; Mice; Protein Processing, Post-Translational; Pyrimidines; Signal Transduction; Ubiquitin-Activating Enzymes; Ubiquitin-Protein Ligases	2013
The IKK inhibitor Bay 11-7082 induces cell death independent from inhibition of activation of NFκB transcription factors. PloS one, 2013, Volume: 8, Issue:3 Topics: Amides; Apoptosis; Blotting, Western; Cell Line; Cell Survival; Cyclopentanes; Enzyme-Linked Immunosorbent Assay; Flow Cytometry; Gene Expression Regulation, Neoplastic; Humans; I-kappa B Kinase; Microscopy, Fluorescence; Multiple Myeloma; NF-kappa B; Nitriles; Pyrimidines; RNA, Small Interfering; Signal Transduction; Sulfones; Thiophenes	2013
Destabilization of CDC6 upon DNA damage is dependent on neddylation but independent of Cullin E3 ligases. The international journal of biochemistry & cell biology, 2013, Volume: 45, Issue:7 Topics: Cell Cycle Proteins; Cullin Proteins; Cyclopentanes; DNA Damage; DNA Replication; G1 Phase; HCT116 Cells; HEK293 Cells; HeLa Cells; Humans; Mitomycin; NEDD8 Protein; Nuclear Proteins; Pyrimidines; RNA Interference; RNA, Small Interfering; Tumor Suppressor Proteins; Ubiquitin-Protein Ligases; Ubiquitination; Ubiquitins	2013
Quantifiable analysis of cellular pathway inhibition of a Nedd8-activating enzyme inhibitor, MLN4924, using AlphaScreen. Analytical biochemistry, 2013, Aug-15, Volume: 439, Issue:2 Topics: Cyclopentanes; Gene Expression Regulation; HCT116 Cells; Humans; Protein Binding; Protein Subunits; Pyrimidines; Ubiquitin-Activating Enzymes	2013
Disrupting protein NEDDylation with MLN4924 is a novel strategy to target cisplatin resistance in ovarian cancer. Clinical cancer research : an official journal of the American Association for Cancer Research, 2013, Jul-01, Volume: 19, Issue:13 Topics: Animals; Apoptosis; Apoptosis Regulatory Proteins; Cell Survival; Cisplatin; Cyclopentanes; DNA Damage; Drug Resistance, Neoplasm; Female; Humans; Membrane Proteins; Mice; Mitochondrial Proteins; NF-kappa B; Ovarian Neoplasms; Proteome; Pyrimidines; Reactive Oxygen Species; Tumor Burden; Tumor Stem Cell Assay; Xenograft Model Antitumor Assays	2013
A fast workflow for identification and quantification of proteomes. Molecular & cellular proteomics : MCP, 2013, Volume: 12, Issue:8 Topics: Chromatography, High Pressure Liquid; Cyclopentanes; HeLa Cells; Hep G2 Cells; Human Umbilical Vein Endothelial Cells; Humans; Proteome; Proteomics; Pyrimidines; Tandem Mass Spectrometry	2013
Absolute quantification of E1, ubiquitin-like proteins and Nedd8-MLN4924 adduct by mass spectrometry. Cell biochemistry and biophysics, 2013, Volume: 67, Issue:1 Topics: Animals; Cell Line; Chromatography, High Pressure Liquid; Cyclopentanes; Female; HCT116 Cells; HeLa Cells; Humans; Isotope Labeling; Nanotechnology; NEDD8 Protein; Peptides; Pyrimidines; Rats; Rats, Nude; Recombinant Proteins; Tandem Mass Spectrometry; Ubiquitin; Ubiquitin-Activating Enzymes; Ubiquitins	2013
Molecular dynamics investigation on the poor sensitivity of A171T mutant NEDD8-activating enzyme (NAE) for MLN4924. Journal of biomolecular structure & dynamics, 2014, Volume: 32, Issue:7 Topics: Cyclopentanes; Humans; Hydrogen Bonding; Molecular Dynamics Simulation; Mutation; Pyrimidines; Ubiquitin-Activating Enzymes	2014
Neddylation plays an important role in the regulation of murine and human dendritic cell function. Blood, 2013, Sep-19, Volume: 122, Issue:12 Topics: Animals; Apoptosis; beta-Transducin Repeat-Containing Proteins; Carrier Proteins; Cell Line; Cyclopentanes; Cytokines; Dendritic Cells; Enzyme Activation; Extracellular Signal-Regulated MAP Kinases; Female; Humans; I-kappa B Proteins; Inflammation Mediators; Lipopolysaccharides; Mice; Mitogen-Activated Protein Kinases; NEDD8 Protein; NF-kappa B; Phenotype; Protein Processing, Post-Translational; Protein Transport; Proteolysis; Pyrimidines; Signal Transduction; T-Lymphocytes; Ubiquitins	2013
Overcoming platinum resistance in preclinical models of ovarian cancer using the neddylation inhibitor MLN4924. Molecular cancer therapeutics, 2013, Volume: 12, Issue:10 Topics: Apoptosis; Carboplatin; Cell Line, Tumor; Cisplatin; Cyclopentanes; Drug Resistance, Neoplasm; Drug Synergism; Fanconi Anemia Complementation Group D2 Protein; Female; Humans; Molecular Targeted Therapy; Ovarian Neoplasms; Pyrimidines; Ubiquitin-Activating Enzymes; Ubiquitination	2013
Inhibition of CUL4A Neddylation causes a reversible block to SAMHD1-mediated restriction of HIV-1. Journal of virology, 2013, Volume: 87, Issue:21 Topics: Cell Line; Cullin Proteins; Cyclopentanes; Enzyme Inhibitors; HIV-1; Humans; Monomeric GTP-Binding Proteins; NEDD8 Protein; Protein Processing, Post-Translational; Pyrimidines; SAM Domain and HD Domain-Containing Protein 1; Ubiquitins; Virus Replication	2013
Ubiquitin E3 ligase CRL4(CDT2/DCAF2) as a potential chemotherapeutic target for ovarian surface epithelial cancer. The Journal of biological chemistry, 2013, Oct-11, Volume: 288, Issue:41 Topics: Animals; Apoptosis; Blotting, Western; Carcinoma, Ovarian Epithelial; Cell Cycle Proteins; Cell Line, Tumor; Cell Survival; Cells, Cultured; Cyclin-Dependent Kinase Inhibitor p21; Cyclin-Dependent Kinase Inhibitor p27; Cyclopentanes; DNA Damage; Dose-Response Relationship, Drug; Female; Gene Expression Regulation, Neoplastic; Humans; Immunohistochemistry; Mice; Mice, Nude; Neoplasms, Glandular and Epithelial; Nuclear Proteins; Ovarian Neoplasms; Pyrimidines; Reverse Transcriptase Polymerase Chain Reaction; RNA Interference; Ubiquitin-Protein Ligases; Xenograft Model Antitumor Assays	2013
TRIAD1 and HHARI bind to and are activated by distinct neddylated Cullin-RING ligase complexes. The EMBO journal, 2013, Oct-30, Volume: 32, Issue:21 Topics: Carrier Proteins; Cullin Proteins; Cyclopentanes; HEK293 Cells; Humans; NEDD8 Protein; Pyrimidines; Ubiquitin; Ubiquitin-Conjugating Enzymes; Ubiquitin-Protein Ligases; Ubiquitination; Ubiquitins	2013
A first-in-class NAE inhibitor, MLN4924, blocks lentiviral infection in myeloid cells by disrupting neddylation-dependent Vpx-mediated SAMHD1 degradation. Journal of virology, 2014, Volume: 88, Issue:1 Topics: Animals; Cyclopentanes; Humans; Lentivirus Infections; Monomeric GTP-Binding Proteins; Pyrimidines; SAM Domain and HD Domain-Containing Protein 1	2014
Endothelial deletion of Sag/Rbx2/Roc2 E3 ubiquitin ligase causes embryonic lethality and blocks tumor angiogenesis. Oncogene, 2014, Oct-30, Volume: 33, Issue:44 Topics: Animals; Carrier Proteins; Cell Movement; Cell Proliferation; Cyclin-Dependent Kinase Inhibitor p27; Cyclopentanes; Embryo Loss; Endothelial Cells; Gene Deletion; Gene Knockdown Techniques; Melanoma, Experimental; Mice, Knockout; NEDD8 Protein; Neovascularization, Pathologic; Pyrimidines; Ubiquitin-Protein Ligases; Ubiquitins	2014
Applications of pathology-assisted image analysis of immunohistochemistry-based biomarkers in oncology. Veterinary pathology, 2014, Volume: 51, Issue:1 Topics: Algorithms; Animals; Apoptosis; Aurora Kinase A; Automation; Azepines; Biomarkers, Pharmacological; Biopsy; Cyclopentanes; Drug Discovery; Drug Evaluation, Preclinical; Humans; Image Processing, Computer-Assisted; Immunohistochemistry; Mitosis; Neoplasms; Pyrimidines; Skin	2014
Lack of SMALL ACIDIC PROTEIN 1 (SMAP1) causes increased sensitivity to an inhibitor of RUB/NEDD8-activating enzyme in Arabidopsis seedlings. Plant signaling & behavior, 2013, Volume: 8, Issue:10 Topics: Arabidopsis; Arabidopsis Proteins; Cyclopentanes; Enzyme Inhibitors; Indoleacetic Acids; Pyrimidines; Seedlings; Ubiquitins	2013
Suppression of tumor angiogenesis by targeting the protein neddylation pathway. Cell death & disease, 2014, Feb-13, Volume: 5 Topics: Angiogenesis Inhibitors; Animals; Apoptosis; Carrier Proteins; Cell Cycle Checkpoints; Cell Line, Tumor; Chick Embryo; Chorioallantoic Membrane; Cullin Proteins; Cyclopentanes; DNA Damage; Dose-Response Relationship, Drug; Endothelial Cells; Human Umbilical Vein Endothelial Cells; Humans; Male; Mice; Mice, Inbred C57BL; Mice, Nude; NEDD8 Protein; Neovascularization, Pathologic; Neovascularization, Physiologic; Pancreatic Neoplasms; Protein Processing, Post-Translational; Pyrimidines; Rats; Rats, Sprague-Dawley; rhoA GTP-Binding Protein; RNA Interference; Time Factors; Tissue Culture Techniques; Transfection; Tumor Burden; Ubiquitin-Activating Enzymes; Ubiquitins; Xenograft Model Antitumor Assays	2014
The Nedd8-activating enzyme inhibitor MLN4924 thwarts microenvironment-driven NF-κB activation and induces apoptosis in chronic lymphocytic leukemia B cells. Clinical cancer research : an official journal of the American Association for Cancer Research, 2014, Mar-15, Volume: 20, Issue:6 Topics: Animals; Antineoplastic Agents; Apoptosis; B-Lymphocytes; Blotting, Western; Cell Line, Tumor; Cyclopentanes; Enzyme Inhibitors; Flow Cytometry; Humans; Immunohistochemistry; Leukemia, Lymphocytic, Chronic, B-Cell; Mice; NF-kappa B; Oligonucleotide Array Sequence Analysis; Polymerase Chain Reaction; Pyrimidines; Real-Time Polymerase Chain Reaction; Signal Transduction; Tumor Microenvironment; Ubiquitin-Activating Enzymes	2014
Structure-based repurposing of FDA-approved drugs as inhibitors of NEDD8-activating enzyme. Biochimie, 2014, Volume: 102 Topics: Adenosine Triphosphate; Cyclopentanes; Drug Approval; Enzyme Inhibitors; Humans; Pyrimidines; Signal Transduction; Ubiquitin-Activating Enzymes; United States; United States Food and Drug Administration; User-Computer Interface	2014
Nedd8-activating enzyme inhibitor MLN4924 provides synergy with mitomycin C through interactions with ATR, BRCA1/BRCA2, and chromatin dynamics pathways. Molecular cancer therapeutics, 2014, Volume: 13, Issue:6 Topics: Animals; Apoptosis; Ataxia Telangiectasia Mutated Proteins; BRCA1 Protein; BRCA2 Protein; Cell Line, Tumor; Chromatin; Cyclopentanes; DNA Damage; Drug Synergism; Humans; Mice; Mitomycin; Pyrimidines; Ubiquitin-Activating Enzymes; Ultraviolet Rays; Xenograft Model Antitumor Assays	2014
Mutations in UBA3 confer resistance to the NEDD8-activating enzyme inhibitor MLN4924 in human leukemic cells. PloS one, 2014, Volume: 9, Issue:4 Topics: Adenosine Triphosphate; Antineoplastic Agents; Cell Line, Tumor; Cullin Proteins; Cyclopentanes; DNA Mutational Analysis; Drug Resistance, Neoplasm; Enzyme Inhibitors; Genotype; Humans; K562 Cells; Leukemia; Models, Molecular; NEDD8 Protein; Point Mutation; Protein Binding; Protein Conformation; Pyrimidines; Structure-Activity Relationship; U937 Cells; Ubiquitin-Activating Enzymes; Ubiquitins	2014
MLN4924, an NAE inhibitor, suppresses AKT and mTOR signaling via upregulation of REDD1 in human myeloma cells. Blood, 2014, May-22, Volume: 123, Issue:21 Topics: Antineoplastic Agents; Apoptosis; Boronic Acids; Bortezomib; Cell Line, Tumor; Cell Proliferation; Cyclopentanes; Humans; Multiple Myeloma; Proteasome Inhibitors; Proto-Oncogene Proteins c-akt; Pyrazines; Pyrimidines; Signal Transduction; TOR Serine-Threonine Kinases; Transcription Factors; Ubiquitin-Activating Enzymes; Up-Regulation	2014
Overactivated neddylation pathway as a therapeutic target in lung cancer. Journal of the National Cancer Institute, 2014, Volume: 106, Issue:6 Topics: Adenocarcinoma; Adenocarcinoma of Lung; Antineoplastic Agents; Carcinoma, Squamous Cell; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cell Survival; Cyclopentanes; Flow Cytometry; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Humans; Immunoblotting; Immunohistochemistry; Lung Neoplasms; Molecular Targeted Therapy; NEDD8 Protein; Pyrimidines; Real-Time Polymerase Chain Reaction; Signal Transduction; Tumor Stem Cell Assay; Ubiquitins	2014
Targeting the neddylation pathway to suppress the growth of prostate cancer cells: therapeutic implication for the men's cancer. BioMed research international, 2014, Volume: 2014 Topics: Apoptosis; Cell Line, Tumor; Cell Survival; Cullin Proteins; Cyclopentanes; DNA Damage; Humans; Male; Molecular Targeted Therapy; Prostatic Neoplasms; Pyrimidines; Signal Transduction; Ubiquitin-Protein Ligases; Ubiquitins	2014
Neddylation pathway is up-regulated in human intrahepatic cholangiocarcinoma and serves as a potential therapeutic target. Oncotarget, 2014, Sep-15, Volume: 5, Issue:17 Topics: Animals; Bile Duct Neoplasms; Bile Ducts, Intrahepatic; Cell Line, Tumor; Cell Separation; Cholangiocarcinoma; Cyclopentanes; Enzyme Inhibitors; Female; Humans; Immunohistochemistry; Male; Mice; Mice, Nude; NEDD8 Protein; Neoplasm Recurrence, Local; Pyrimidines; Signal Transduction; Tissue Array Analysis; Ubiquitin-Activating Enzymes; Ubiquitin-Conjugating Enzymes; Ubiquitins; Up-Regulation; Xenograft Model Antitumor Assays	2014
CBS9106-induced CRM1 degradation is mediated by cullin ring ligase activity and the neddylation pathway. Molecular cancer therapeutics, 2014, Volume: 13, Issue:12 Topics: Aminopyridines; Apoptosis; Carrier Proteins; Cell Cycle; Cell Line, Tumor; Cell Nucleus; Cell Survival; COP9 Signalosome Complex; Cullin Proteins; Cyclopentanes; Exportin 1 Protein; Gene Knockdown Techniques; HCT116 Cells; Humans; Intracellular Signaling Peptides and Proteins; Karyopherins; Lysosomes; NEDD8 Protein; Nuclear Proteins; Peptide Hydrolases; Protein Transport; Proteolysis; Pyrimidines; Pyrrolidinones; Receptors, Cytoplasmic and Nuclear; Signal Transduction; Transcription Factors; Tumor Suppressor Protein p53; Ubiquitin-Activating Enzymes; Ubiquitins	2014
Stabilization of HIF through inhibition of Cullin-2 neddylation is protective in mucosal inflammatory responses. FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2015, Volume: 29, Issue:1 Topics: Animals; Cell Line; Cullin Proteins; Cyclopentanes; Disease Models, Animal; Endopeptidases; Gene Knockdown Techniques; HeLa Cells; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Inflammatory Bowel Diseases; Intestinal Mucosa; Metabolic Networks and Pathways; Mice, Inbred C57BL; NEDD8 Protein; Protease Inhibitors; Protein Stability; Pyrimidines; Ubiquitins	2015
MLN4924 sensitizes monocytes and maturing dendritic cells for TNF-dependent and -independent necroptosis. British journal of pharmacology, 2015, Volume: 172, Issue:5 Topics: Apoptosis; Cyclopentanes; Dendritic Cells; Dose-Response Relationship, Drug; Humans; Lipopolysaccharides; Monocytes; Necrosis; NF-kappa B; Pyrimidines; Structure-Activity Relationship; Tumor Necrosis Factor-alpha	2015
The NEDD8-activating enzyme inhibitor MLN4924 disrupts nucleotide metabolism and augments the efficacy of cytarabine. Clinical cancer research : an official journal of the American Association for Cancer Research, 2015, Jan-15, Volume: 21, Issue:2 Topics: Animals; Apoptosis; Cell Cycle Proteins; Cell Line, Tumor; Cell Survival; Cyclopentanes; Cytarabine; Drug Synergism; Gene Knockdown Techniques; Humans; Mice, Nude; NEDD8 Protein; Nucleotides; Protein Stability; Pyrimidines; Ubiquitins; Xenograft Model Antitumor Assays	2015
MLN4924, a novel protein neddylation inhibitor, suppresses proliferation and migration of human urothelial carcinoma: In vitro and in vivo studies. Cancer letters, 2015, Jul-28, Volume: 363, Issue:2 Topics: Animals; Apoptosis; Carcinoma; Cell Cycle Checkpoints; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cyclopentanes; Flow Cytometry; Humans; Mice; NEDD8 Protein; Pyrimidines; Ubiquitin-Activating Enzymes; Ubiquitins; Urologic Neoplasms; Xenograft Model Antitumor Assays	2015
Stabilization of LKB1 and Akt by neddylation regulates energy metabolism in liver cancer. Oncotarget, 2015, Feb-10, Volume: 6, Issue:4 Topics: AMP-Activated Protein Kinase Kinases; Animals; Blotting, Western; Carcinoma, Hepatocellular; Cyclopentanes; Energy Metabolism; Hep G2 Cells; Hepatocytes; Humans; Liver Neoplasms; Male; Mice, Inbred C57BL; Mice, Knockout; Mice, Nude; NEDD8 Protein; Prohibitins; Protein Processing, Post-Translational; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins c-akt; Pyrimidines; Repressor Proteins; Reverse Transcriptase Polymerase Chain Reaction; RNA Interference; Signal Transduction; Transplantation, Heterologous; Ubiquitins	2015
NEDDylation promotes endothelial dysfunction: a role for HDAC2. Journal of molecular and cellular cardiology, 2015, Volume: 81 Topics: Animals; Aorta; Arginase; Atherosclerosis; Cell Line; Cyclopentanes; Endopeptidases; Endothelial Cells; Endothelium, Vascular; Enzyme Inhibitors; Histone Deacetylase 2; Humans; Lipoproteins, LDL; Mice; NEDD8 Protein; Proteasome Endopeptidase Complex; Protein Processing, Post-Translational; Proteolysis; Pyrimidines; Signal Transduction; Tissue Culture Techniques; Ubiquitination; Ubiquitins	2015
Synaptic structure and function are altered by the neddylation inhibitor MLN4924. Molecular and cellular neurosciences, 2015, Volume: 65 Topics: Animals; Cells, Cultured; Cyclopentanes; Enzyme Inhibitors; Hippocampus; Neurons; Pyrimidines; Rats; Receptors, Glutamate; Synapses; Synaptic Potentials; Ubiquitin; Ubiquitination	2015
Targeting protein neddylation with an NEDD8-activating enzyme inhibitor MLN4924 induced apoptosis or senescence in human lymphoma cells. Cancer biology & therapy, 2015, Volume: 16, Issue:3 Topics: Apoptosis; Cell Line, Tumor; Cell Proliferation; Cell Survival; Cellular Senescence; Cullin Proteins; Cyclopentanes; Gene Expression Regulation, Leukemic; Humans; Lymphoma; NEDD8 Protein; Protein Processing, Post-Translational; Pyrimidines; Signal Transduction; Ubiquitin-Protein Ligases; Ubiquitins	2015
NEDDylation is essential for Kaposi's sarcoma-associated herpesvirus latency and lytic reactivation and represents a novel anti-KSHV target. PLoS pathogens, 2015, Volume: 11, Issue:3 Topics: Cell Line, Tumor; Cyclopentanes; DNA Replication; DNA, Viral; Gene Expression Regulation, Viral; HEK293 Cells; Herpesvirus 8, Human; Humans; NEDD8 Protein; NF-kappa B; Pyrimidines; Sarcoma, Kaposi; Ubiquitins; Virus Activation	2015
Synergistic inhibition of autophagy and neddylation pathways as a novel therapeutic approach for targeting liver cancer. Oncotarget, 2015, Apr-20, Volume: 6, Issue:11 Topics: Antineoplastic Agents; Apoptosis Regulatory Proteins; Autophagy; Carcinoma, Hepatocellular; Cell Line, Tumor; Chloroquine; Cyclopentanes; DNA Damage; Drug Synergism; Gene Expression Regulation, Neoplastic; Humans; Liver Neoplasms; Macrolides; Molecular Targeted Therapy; NEDD8 Protein; Neoplasm Proteins; Protein Processing, Post-Translational; Proto-Oncogene Proteins c-bcl-2; Pyrimidines; Random Allocation; RNA, Small Interfering; Transfection; Ubiquitins; Xenograft Model Antitumor Assays	2015
The NEDD8 inhibitor MLN4924 increases the size of the nucleolus and activates p53 through the ribosomal-Mdm2 pathway. Oncogene, 2016, Jan-28, Volume: 35, Issue:4 Topics: Animals; Caenorhabditis elegans; Caenorhabditis elegans Proteins; Cell Line; Cell Nucleolus; Cyclopentanes; Genes, p53; Humans; MCF-7 Cells; Metabolic Networks and Pathways; Mice, Mutant Strains; NEDD8 Protein; Proto-Oncogene Proteins c-mdm2; Pyrimidines; Ribosomal Proteins; Ribosomes; Ubiquitins	2016
Suppression of glioblastoma by targeting the overactivated protein neddylation pathway. Neuro-oncology, 2015, Volume: 17, Issue:10 Topics: Antineoplastic Agents; Apoptosis; Brain Neoplasms; Cell Cycle Checkpoints; Cell Line, Tumor; Cullin Proteins; Cyclopentanes; Disease Progression; Glioblastoma; Humans; NEDD8 Protein; Pyrimidines; Signal Transduction; Ubiquitins; Xenograft Model Antitumor Assays	2015
Neddylation promotes ubiquitylation and release of Ku from DNA-damage sites. Cell reports, 2015, May-05, Volume: 11, Issue:5 Topics: Antigens, Nuclear; Cell Line; Cell Survival; Cyclopentanes; DNA Damage; DNA End-Joining Repair; DNA-Binding Proteins; Histones; Humans; Ku Autoantigen; NEDD8 Protein; Protein Binding; Protein Structure, Tertiary; Proteomics; Pyrimidines; Radiation, Ionizing; RNA Interference; RNA, Small Interfering; Ubiquitin-Conjugating Enzymes; Ubiquitination; Ubiquitins	2015
Pharmacological targeting of miR-155 via the NEDD8-activating enzyme inhibitor MLN4924 (Pevonedistat) in FLT3-ITD acute myeloid leukemia. Leukemia, 2015, Volume: 29, Issue:10 Topics: Animals; Apoptosis; Blotting, Western; Cell Differentiation; Cell Proliferation; Chromatin Immunoprecipitation; Cyclopentanes; Drug Resistance, Neoplasm; Female; fms-Like Tyrosine Kinase 3; Gene Expression Regulation, Leukemic; Humans; Leukemia, Myeloid, Acute; Mice; Mice, Inbred NOD; Mice, SCID; MicroRNAs; Monocytes; NEDD8 Protein; NF-kappa B; Promoter Regions, Genetic; Pyrimidines; Real-Time Polymerase Chain Reaction; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Signal Transduction; Tandem Repeat Sequences; Tumor Cells, Cultured; Ubiquitins; Xenograft Model Antitumor Assays	2015
MLN4924 induces Noxa upregulation in acute myelogenous leukemia and synergizes with Bcl-2 inhibitors. Cell death and differentiation, 2015, Volume: 22, Issue:12 Topics: Antineoplastic Agents; Apoptosis; Bridged Bicyclo Compounds, Heterocyclic; Cell Line, Tumor; Cyclopentanes; Drug Synergism; HL-60 Cells; Humans; Leukemia, Myeloid, Acute; Myeloid Cell Leukemia Sequence 1 Protein; Proto-Oncogene Proteins c-bcl-2; Proto-Oncogene Proteins c-myc; Pyrimidines; RNA Interference; RNA, Small Interfering; Sulfonamides; Up-Regulation	2015
Radiosensitization of Human Colorectal Cancer Cells by MLN4924: An Inhibitor of NEDD8-Activating Enzyme. Technology in cancer research & treatment, 2016, Volume: 15, Issue:4 Topics: Apoptosis; Cell Line, Tumor; Colorectal Neoplasms; Cyclin-Dependent Kinase Inhibitor p27; Cyclopentanes; DNA Damage; Dose-Response Relationship, Drug; Dose-Response Relationship, Radiation; G2 Phase Cell Cycle Checkpoints; Gene Knockdown Techniques; Humans; NEDD8 Protein; Pyrimidines; Radiation-Sensitizing Agents; RNA, Small Interfering; Ubiquitins; X-Rays	2016
Targeting neddylation effectively antagonizes nuclear factor-κB in chronic lymphocytic leukemia B-cells. Leukemia & lymphoma, 2015, Volume: 56, Issue:5 Topics: Apoptosis; Cell Line, Tumor; Cyclopentanes; Gene Expression Regulation, Leukemic; Humans; Leukemia, Lymphocytic, Chronic, B-Cell; NEDD8 Protein; NF-kappa B; Pyrimidines; Transcription, Genetic; Ubiquitins	2015
NEDD8 Inhibition Overcomes CKS1B-Induced Drug Resistance by Upregulation of p21 in Multiple Myeloma. Clinical cancer research : an official journal of the American Association for Cancer Research, 2015, Dec-15, Volume: 21, Issue:24 Topics: Antineoplastic Agents; Apoptosis; Bortezomib; CDC2-CDC28 Kinases; Cell Line, Tumor; Cell Survival; Cyclin-Dependent Kinase Inhibitor p21; Cyclopentanes; Drug Resistance, Neoplasm; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Humans; Kaplan-Meier Estimate; Multiple Myeloma; NEDD8 Protein; Proteolysis; Pyrimidines; Signal Transduction; Ubiquitins	2015
Targeting neddylation induces DNA damage and checkpoint activation and sensitizes chronic lymphocytic leukemia B cells to alkylating agents. Cell death & disease, 2015, Jul-09, Volume: 6 Topics: Alkylating Agents; Apoptosis; B-Lymphocytes; Bendamustine Hydrochloride; CD40 Antigens; CD40 Ligand; Cell Cycle Checkpoints; Cell Line, Tumor; Cell Proliferation; Cyclopentanes; DNA Damage; Gene Expression Regulation, Neoplastic; Humans; Interleukins; Leukemia, Lymphocytic, Chronic, B-Cell; NEDD8 Protein; NF-kappa B; Pyrimidines; Ubiquitin-Activating Enzymes; Ubiquitins	2015
HIV-1 Vpu utilizes both cullin-RING ligase (CRL) dependent and independent mechanisms to downmodulate host proteins. Retrovirology, 2015, Jul-28, Volume: 12 Topics: beta-Transducin Repeat-Containing Proteins; CD4 Antigens; CD4-Positive T-Lymphocytes; Cells, Cultured; Cullin Proteins; Cyclopentanes; Down-Regulation; HIV-1; Human Immunodeficiency Virus Proteins; Humans; Pyrimidines; Receptors, CCR7; Ubiquitin-Protein Ligases; Viral Regulatory and Accessory Proteins	2015
High Efficiency Apoptosis Induction in Breast Cancer Cell Lines by MLN4924/2DG Co-Treatment. Asian Pacific journal of cancer prevention : APJCP, 2015, Volume: 16, Issue:13 Topics: Antimetabolites; Apoptosis; Blotting, Western; Breast Neoplasms; Cell Proliferation; Cyclopentanes; Deoxyglucose; Drug Therapy, Combination; Female; Humans; In Situ Nick-End Labeling; Pyrimidines; Real-Time Polymerase Chain Reaction; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Tumor Cells, Cultured; Ubiquitin-Activating Enzymes	2015
The novel protective role of P27 in MLN4924-treated gastric cancer cells. Cell death & disease, 2015, Aug-27, Volume: 6 Topics: Animals; Antineoplastic Agents; Antioxidants; Apoptosis Inducing Factor; Apoptosis Regulatory Proteins; Cell Line, Tumor; Cullin Proteins; Cyclin-Dependent Kinase Inhibitor p27; Cyclopentanes; Cytochromes c; Embryo, Nonmammalian; F-Box Proteins; G2 Phase Cell Cycle Checkpoints; Gene Expression Regulation, Neoplastic; Humans; Intracellular Signaling Peptides and Proteins; Mitochondrial Proteins; Pyrimidines; Reactive Oxygen Species; RNA, Small Interfering; S-Phase Kinase-Associated Proteins; Signal Transduction; Stomach Neoplasms; Xenograft Model Antitumor Assays; Zebrafish	2015
Comprehensive quantitative proteomic profiling of the pharmacodynamic changes induced by MLN4924 in acute myeloid leukemia cells establishes rationale for its combination with azacitidine. Leukemia, 2016, Volume: 30, Issue:5 Topics: Azacitidine; Cell Line, Tumor; Cyclopentanes; Humans; Leukemia, Myeloid, Acute; Neoplasm Proteins; Proteomics; Pyrimidines	2016
Golgi Associated HIF1a Serves as a Reserve in Melanoma Cells. Journal of cellular biochemistry, 2016, Volume: 117, Issue:4 Topics: Amino Acids, Dicarboxylic; Cell Hypoxia; Cell Line, Tumor; Cell Nucleus; Chloroquine; Cyclopentanes; Endoplasmic Reticulum; Gene Expression Regulation, Neoplastic; Golgi Apparatus; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Lysosomes; Melanocytes; Oxygen; Prolyl Hydroxylases; Prolyl-Hydroxylase Inhibitors; Proteasome Endopeptidase Complex; Protein Folding; Protein Transport; Proteolysis; Pyrimidines; RNA, Messenger; Signal Transduction; Transcription, Genetic	2016
MLN4924 Synergistically Enhances Cisplatin-induced Cytotoxicity via JNK and Bcl-xL Pathways in Human Urothelial Carcinoma. Scientific reports, 2015, Nov-23, Volume: 5 Topics: Animals; Antineoplastic Agents; Apoptosis; bcl-X Protein; Carcinoma, Transitional Cell; Caspase 3; Caspase 7; Cell Line, Tumor; Cisplatin; Cyclopentanes; Drug Combinations; Drug Synergism; Gene Expression Regulation, Neoplastic; Histones; Humans; MAP Kinase Kinase 4; Mice; Mice, Nude; NEDD8 Protein; Neoplasm Grading; Poly(ADP-ribose) Polymerases; Pyrimidines; Signal Transduction; Ubiquitins; Urinary Bladder Neoplasms; Xenograft Model Antitumor Assays	2015
Pevonedistat, a NEDD8-activating enzyme inhibitor, is active in mantle cell lymphoma and enhances rituximab activity in vivo. Blood, 2016, Mar-03, Volume: 127, Issue:9 Topics: Animals; Antineoplastic Agents; Apoptosis; Caspases; Cell Cycle Checkpoints; Cell Line, Tumor; Cell Separation; Cell Survival; Cyclopentanes; Enzyme Inhibitors; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Humans; Lymphoma, Mantle-Cell; Mice, SCID; NEDD8 Protein; NF-kappa B; Proto-Oncogene Proteins c-bcl-2; Pyrimidines; Rituximab; Small Molecule Libraries; Ubiquitins	2016
Chemogenomic Study of Carboplatin in Saccharomyces cerevisiae: Inhibition of the NEDDylation Process Overcomes Cellular Resistance Mediated by HuR and Cullin Proteins. PloS one, 2015, Volume: 10, Issue:12 Topics: Carboplatin; Cell Line, Tumor; Chromosomes, Human, Pair 1; Cullin Proteins; Cyclopentanes; Drug Resistance, Fungal; Drug Resistance, Neoplasm; ELAV-Like Protein 1; Female; Gene Expression Profiling; Humans; Mutation; Ovarian Neoplasms; Pyrimidines; Saccharomyces cerevisiae; Ubiquitin-Activating Enzymes	2015
FBXW7 Facilitates Nonhomologous End-Joining via K63-Linked Polyubiquitylation of XRCC4. Molecular cell, 2016, Feb-04, Volume: 61, Issue:3 Topics: Amino Acid Sequence; Animals; Ataxia Telangiectasia Mutated Proteins; Cell Cycle Proteins; Cyclopentanes; DNA Breaks, Double-Stranded; DNA End-Joining Repair; DNA-Activated Protein Kinase; DNA-Binding Proteins; Enzyme Inhibitors; F-Box Proteins; F-Box-WD Repeat-Containing Protein 7; HCT116 Cells; Humans; Lysine; Mice, Knockout; Molecular Sequence Data; Nuclear Proteins; Pancreatic Neoplasms; Phosphorylation; Polyubiquitin; Protein Processing, Post-Translational; Pyrimidines; Radiation Tolerance; Radiation-Sensitizing Agents; RNA Interference; Time Factors; Transfection; Ubiquitin-Activating Enzymes; Ubiquitin-Protein Ligases; Ubiquitination; Ubiquitins	2016
Broad and potent antiviral activity of the NAE inhibitor MLN4924. Scientific reports, 2016, Feb-01, Volume: 6 Topics: Animals; Antiviral Agents; Cyclopentanes; DNA Virus Infections; DNA Viruses; Humans; Mice; NEDD8 Protein; NIH 3T3 Cells; Orthomyxoviridae; Orthomyxoviridae Infections; Pyrimidines; Ubiquitins	2016
The NAE inhibitor pevonedistat interacts with the HDAC inhibitor belinostat to target AML cells by disrupting the DDR. Blood, 2016, 05-05, Volume: 127, Issue:18 Topics: Animals; Apoptosis; Bcl-2-Like Protein 11; Cell Cycle Proteins; Cells, Cultured; Checkpoint Kinase 1; Cyclopentanes; DNA Damage; DNA Repair; Drug Synergism; Histone Deacetylase Inhibitors; Humans; Hydroxamic Acids; Kaplan-Meier Estimate; Leukemia, Myeloid, Acute; Mice; Molecular Targeted Therapy; Myelodysplastic Syndromes; Neoplasm Proteins; NF-kappa B; Nuclear Proteins; Protein Processing, Post-Translational; Protein-Tyrosine Kinases; Pyrimidines; RNA Interference; RNA, Small Interfering; S Phase Cell Cycle Checkpoints; Sulfonamides; U937 Cells; Ubiquitin-Activating Enzymes; Xenograft Model Antitumor Assays	2016
MLN4924, a First-in-Class NEDD8-Activating Enzyme Inhibitor, Attenuates IFN-β Production. Journal of immunology (Baltimore, Md. : 1950), 2016, Apr-01, Volume: 196, Issue:7 Topics: Animals; Cell Line; Cyclopentanes; Female; Humans; Interferon Regulatory Factor-3; Interferon-beta; Macrophages, Peritoneal; Mice; NEDD8 Protein; Phosphorylation; Promoter Regions, Genetic; Protein Binding; Pyrimidines; Transcription, Genetic; Transcriptional Activation; Ubiquitins; Virus Replication	2016
The MLN4924 inhibitor exerts a neuroprotective effect against oxidative stress injury via Nrf2 protein accumulation. Redox biology, 2016, Volume: 8 Topics: Animals; Antioxidants; Cell Survival; Cerebellum; Cyclopentanes; Cytoprotection; Humans; Hydrogen Peroxide; Neurons; Neuroprotective Agents; NF-E2-Related Factor 2; Oxidative Stress; Primary Cell Culture; Pyrimidines; Rats; Reactive Oxygen Species; Signal Transduction; Ubiquitin-Activating Enzymes	2016
Neddylation Inhibition Activates the Extrinsic Apoptosis Pathway through ATF4-CHOP-DR5 Axis in Human Esophageal Cancer Cells. Clinical cancer research : an official journal of the American Association for Cancer Research, 2016, Aug-15, Volume: 22, Issue:16 Topics: Activating Transcription Factor 4; Animals; Apoptosis; BH3 Interacting Domain Death Agonist Protein; Biomarkers; Caspase 8; Cell Line, Tumor; Cyclopentanes; Disease Models, Animal; Esophageal Neoplasms; Gene Silencing; Humans; Mice; Models, Biological; Prognosis; Pyrimidines; Receptors, TNF-Related Apoptosis-Inducing Ligand; RNA Interference; Signal Transduction; Transcription Factor CHOP; Xenograft Model Antitumor Assays	2016
PPARγ neddylation essential for adipogenesis is a potential target for treating obesity. Cell death and differentiation, 2016, Volume: 23, Issue:8 Topics: 3T3-L1 Cells; Abdominal Fat; Adipocytes; Adipogenesis; Animals; CCAAT-Enhancer-Binding Protein-beta; CCAAT-Enhancer-Binding Protein-delta; CCAAT-Enhancer-Binding Proteins; Cell Cycle Checkpoints; Cell Differentiation; Cyclopentanes; Glucose Intolerance; HEK293 Cells; Humans; Male; Mice; Mice, Inbred C57BL; NEDD8 Protein; Obesity; PPAR gamma; Protein Binding; Proto-Oncogene Proteins c-mdm2; Pyrimidines; Ubiquitins	2016
The NEDD8-activating enzyme inhibitor MLN4924 induces G2 arrest and apoptosis in T-cell acute lymphoblastic leukemia. Oncotarget, 2016, Apr-26, Volume: 7, Issue:17 Topics: Animals; Apoptosis; Biomarkers, Tumor; Cell Cycle Checkpoints; Cell Proliferation; Cyclopentanes; G2 Phase; Humans; Male; Mice; Mice, Inbred NOD; Mice, SCID; NEDD8 Protein; Precursor T-Cell Lymphoblastic Leukemia-Lymphoma; Pyrimidines; Tumor Cells, Cultured; Xenograft Model Antitumor Assays	2016
Neddylation inhibitor MLN4924 suppresses growth and migration of human gastric cancer cells. Scientific reports, 2016, Apr-11, Volume: 6 Topics: Autophagy; Cadherins; Carrier Proteins; Cell Cycle Proteins; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cellular Senescence; Cullin Proteins; Cyclin-Dependent Kinase Inhibitor p21; Cyclopentanes; G2 Phase Cell Cycle Checkpoints; Humans; M Phase Cell Cycle Checkpoints; Matrix Metalloproteinase 9; NEDD8 Protein; Nuclear Proteins; Phosphoprotein Phosphatases; Protein Processing, Post-Translational; Pyrimidines; RNA Interference; RNA, Small Interfering; Stomach Neoplasms; Ubiquitin-Protein Ligases; Ubiquitins	2016
Blockage of neddylation modification stimulates tumor sphere formation in vitro and stem cell differentiation and wound healing in vivo. Proceedings of the National Academy of Sciences of the United States of America, 2016, May-24, Volume: 113, Issue:21 Topics: Animals; Cell Differentiation; Cyclopentanes; Humans; MAP Kinase Signaling System; MCF-7 Cells; Mice; Mice, Inbred BALB C; Mice, Nude; Mice, SCID; NEDD8 Protein; Proto-Oncogene Proteins c-myc; Pyrimidines; Spheroids, Cellular; Stem Cells; Ubiquitins; Wound Healing	2016
MLN4924 suppresses neddylation and induces cell cycle arrest, senescence, and apoptosis in human osteosarcoma. Oncotarget, 2016, Jul-19, Volume: 7, Issue:29 Topics: Animals; Apoptosis; Bone Neoplasms; Cellular Senescence; Cullin Proteins; Cyclopentanes; DNA Damage; G2 Phase Cell Cycle Checkpoints; Humans; Mice; Osteosarcoma; Protein Processing, Post-Translational; Pyrimidines; Ubiquitin-Activating Enzymes; Xenograft Model Antitumor Assays	2016
Radiosensitization by the investigational NEDD8-activating enzyme inhibitor MLN4924 (pevonedistat) in hormone-resistant prostate cancer cells. Oncotarget, 2016, Jun-21, Volume: 7, Issue:25 Topics: Cell Line, Tumor; Cyclopentanes; Enzyme Inhibitors; Humans; Male; NEDD8 Protein; Prostatic Neoplasms, Castration-Resistant; Pyrimidines; Radiation-Sensitizing Agents	2016
Inhibition of neddylation regulates dendritic cell functions via Deptor accumulation driven mTOR inactivation. Oncotarget, 2016, Jun-14, Volume: 7, Issue:24 Topics: Animals; Apoptosis; Caspase 3; Caspase 7; Cell Differentiation; Cells, Cultured; Cullin Proteins; Cyclopentanes; Cytokines; Dendritic Cells; Disease Models, Animal; Down-Regulation; Enzyme Inhibitors; Humans; Inflammatory Bowel Diseases; Intracellular Signaling Peptides and Proteins; Male; Mice; Mice, Inbred C57BL; Protein Processing, Post-Translational; Pyrimidines; Signal Transduction; TOR Serine-Threonine Kinases	2016
Inactivation of the CRL4-CDT2-SET8/p21 ubiquitylation and degradation axis underlies the therapeutic efficacy of pevonedistat in melanoma. EBioMedicine, 2016, Volume: 10 Topics: Animals; Antineoplastic Agents; Cell Cycle Checkpoints; Cell Line, Tumor; Cell Proliferation; Cellular Senescence; Cyclin-Dependent Kinase Inhibitor p21; Cyclopentanes; Disease Models, Animal; Female; Gene Expression; Gene Silencing; Genes, ras; Histone-Lysine N-Methyltransferase; Humans; Kaplan-Meier Estimate; Melanoma; Mice; Mutation; Nuclear Proteins; Prognosis; Protein Stability; Proto-Oncogene Proteins B-raf; Pyrimidines; RNA Interference; Ubiquitin-Protein Ligases; Ubiquitination; Xenograft Model Antitumor Assays	2016
SAG/Rbx2-Dependent Neddylation Regulates T-Cell Responses. The American journal of pathology, 2016, Volume: 186, Issue:10 Topics: Animals; Carrier Proteins; Cyclopentanes; Female; Gene Expression Profiling; Graft vs Host Disease; Humans; Immunity, Cellular; Mice, Inbred C57BL; Mice, Knockout; Oligonucleotide Array Sequence Analysis; Protein Processing, Post-Translational; Pyrimidines; Signal Transduction; T-Lymphocytes; Ubiquitin-Protein Ligases; Ubiquitination	2016
Neddylation is required for herpes simplex virus type I (HSV-1)-induced early phase interferon-beta production. Cellular & molecular immunology, 2016, Volume: 13, Issue:5 Topics: Animals; Cell Nucleus; Cyclopentanes; Cysteine Endopeptidases; Herpes Simplex; Herpesvirus 1, Human; Humans; Interferon Regulatory Factor-3; Interferon-beta; Mice, Inbred C57BL; NF-kappa B; Phenylenediamines; Pyrimidines; Ubiquitins	2016
Circadian clock components RORα and Bmal1 mediate the anti-proliferative effect of MLN4924 in osteosarcoma cells. Oncotarget, 2016, Oct-04, Volume: 7, Issue:40 Topics: Animals; Apoptosis; ARNTL Transcription Factors; Biomarkers, Tumor; Bone Neoplasms; Cell Proliferation; Circadian Clocks; Cyclopentanes; Enzyme Inhibitors; Humans; Mice; Mice, Nude; Nuclear Receptor Subfamily 1, Group F, Member 1; Osteosarcoma; Pyrimidines; Tumor Cells, Cultured; Xenograft Model Antitumor Assays	2016
The NEDD8-activating enzyme inhibitor pevonedistat activates the eIF2α and mTOR pathways inducing UPR-mediated cell death in acute lymphoblastic leukemia. Leukemia research, 2016, Volume: 50 Topics: Animals; Antineoplastic Agents; Cell Death; Cell Line, Tumor; Cyclopentanes; Endoplasmic Reticulum Stress; Enzyme Inhibitors; Eukaryotic Initiation Factor-2; Heterografts; Humans; Mice; NEDD8 Protein; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Pyrimidines; TOR Serine-Threonine Kinases; Ubiquitins; Unfolded Protein Response	2016
An inhibitor of apoptosis protein antagonist T-3256336 potentiates the antitumor efficacy of the Nedd8-activating enzyme inhibitor pevonedistat (TAK-924/MLN4924). Biochemical and biophysical research communications, 2016, Nov-18, Volume: 480, Issue:3 Topics: Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Cell Line, Tumor; Cell Survival; Cyclopentanes; Dose-Response Relationship, Drug; Drug Synergism; Humans; Inhibitor of Apoptosis Proteins; Mice; NEDD8 Protein; Neoplasms, Experimental; Oligopeptides; Pyrazines; Pyrimidines; Treatment Outcome; Ubiquitins	2016
Efficacy of NEDD8 Pathway Inhibition in Preclinical Models of Poorly Differentiated, Clinically Aggressive Colorectal Cancer. Journal of the National Cancer Institute, 2017, Volume: 109, Issue:2 Topics: Adenocarcinoma, Mucinous; Animals; Antineoplastic Agents; Apoptosis; Cadherins; CDX2 Transcription Factor; Cell Line, Tumor; Cell Proliferation; Cetuximab; Colorectal Neoplasms; Cyclopentanes; Disease-Free Survival; DNA Replication; Drug Resistance, Neoplasm; Female; Homeodomain Proteins; Humans; Keratin-20; Mice; NEDD8 Protein; Neoplasm Grading; Neoplasm Transplantation; Proto-Oncogene Proteins B-raf; Proto-Oncogene Proteins p21(ras); Pyrimidines; Signal Transduction; Transcriptome; Ubiquitins	2017
Prostate cancer-associated mutation in SPOP impairs its ability to target Cdc20 for poly-ubiquitination and degradation. Cancer letters, 2017, 01-28, Volume: 385 Topics: Antineoplastic Agents; Carbamates; Cdc20 Proteins; Cullin Proteins; Cyclopentanes; Diamines; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm; Enzyme Inhibitors; HeLa Cells; Humans; Male; Molecular Targeted Therapy; Mutation; Nuclear Proteins; Prostatic Neoplasms; Protein Interaction Domains and Motifs; Proteolysis; Pyrimidines; Repressor Proteins; Time Factors; Transfection; Ubiquitination	2017
Targeting the protein ubiquitination machinery in melanoma by the NEDD8-activating enzyme inhibitor pevonedistat (MLN4924). Investigational new drugs, 2017, Volume: 35, Issue:1 Topics: Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cell Survival; Cyclopentanes; Gene Expression Regulation, Neoplastic; Humans; Melanoma; Pyrimidines; Ubiquitin-Activating Enzymes; Ubiquitination	2017
Therapeutic Effects of a NEDD8-Activating Enzyme Inhibitor, Pevonedistat, on Sclerodermatous Graft-versus-Host Disease in Mice. Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation, 2017, Volume: 23, Issue:1 Topics: Animals; Antigen-Presenting Cells; Cyclopentanes; Enzyme Inhibitors; Graft vs Host Disease; Graft vs Tumor Effect; Hematopoietic Stem Cell Transplantation; Lymphoma, B-Cell; Mice; Pyrimidines; Scleroderma, Systemic; T-Lymphocytes; Time Factors; Transplantation, Homologous; Ubiquitin-Activating Enzymes	2017
The use of the NEDD8 inhibitor MLN4924 (Pevonedistat) in a cyclotherapy approach to protect wild-type p53 cells from MLN4924 induced toxicity. Scientific reports, 2016, 11-30, Volume: 6 Topics: Apoptosis; Cell Line, Tumor; Cyclopentanes; HCT116 Cells; Humans; NEDD8 Protein; Pyrimidines; Tumor Suppressor Protein p53; Ubiquitins	2016
Distinct outcomes of CRL-Nedd8 pathway inhibition reveal cancer cell plasticity. Cell death & disease, 2016, 12-01, Volume: 7, Issue:12 Topics: Cell Line, Tumor; Cell Lineage; Cell Plasticity; Cell Proliferation; Cell Survival; Cyclopentanes; Gene Knockdown Techniques; Humans; Male; Models, Biological; NEDD8 Protein; Prostatic Neoplasms; Pyrimidines; Receptors, Androgen; Signal Transduction; Spheroids, Cellular; Transcription, Genetic; Transcriptional Regulator ERG; Ubiquitin-Protein Ligases; Ubiquitins	2016
Neddylated Cullin 3 is required for vascular endothelial-cadherin-mediated endothelial barrier function. Cancer science, 2017, Volume: 108, Issue:2 Topics: Antigens, CD; Cadherins; Capillary Permeability; Cell Communication; Cullin Proteins; Cycloheximide; Cyclopentanes; Endothelium, Vascular; Human Umbilical Vein Endothelial Cells; Humans; NEDD8 Protein; Protein Synthesis Inhibitors; Pyrimidines; RNA, Messenger; RNA, Small Interfering; Ubiquitins	2017
MLN4924 suppresses the BRCA1 complex and synergizes with PARP inhibition in NSCLC cells. Biochemical and biophysical research communications, 2017, 01-29, Volume: 483, Issue:1 Topics: Antineoplastic Combined Chemotherapy Protocols; BRCA1 Protein; Carcinoma, Non-Small-Cell Lung; Carrier Proteins; Cell Line, Tumor; Cyclopentanes; DNA Damage; DNA-Binding Proteins; Histone Chaperones; Humans; Kaplan-Meier Estimate; Lung Neoplasms; Multiprotein Complexes; NEDD8 Protein; Nuclear Proteins; Phthalazines; Piperazines; Poly (ADP-Ribose) Polymerase-1; Poly(ADP-ribose) Polymerase Inhibitors; Pyrimidines; Tumor Suppressor Proteins; Ubiquitin-Protein Ligases; Ubiquitins	2017
Deregulated neddylation in liver fibrosis. Hepatology (Baltimore, Md.), 2017, Volume: 65, Issue:2 Topics: Aging; Analysis of Variance; Animals; Apoptosis; Biopsy, Needle; Cell Proliferation; Cell Survival; Cells, Cultured; Chemokine CCL4; Chemokines; Cyclopentanes; Disease Models, Animal; Hepatic Stellate Cells; Humans; Immunohistochemistry; Liver Cirrhosis; Male; Mice; Mice, Inbred C57BL; NEDD8 Protein; Pyrimidines; Random Allocation; Signal Transduction; Ubiquitins	2017
Pevonedistat, a Nedd8-activating enzyme inhibitor, sensitizes neoplastic B-cells to death receptor-mediated apoptosis. Oncotarget, 2017, Mar-28, Volume: 8, Issue:13 Topics: Antineoplastic Agents; Apoptosis; B-Lymphocytes; Cyclopentanes; Enzyme Inhibitors; Humans; Immunoblotting; Immunoprecipitation; Lymphoma, Large B-Cell, Diffuse; NEDD8 Protein; Pyrimidines; Receptors, Death Domain; Ubiquitins	2017
The CUL3-SPOP-DAXX axis is a novel regulator of VEGFR2 expression in vascular endothelial cells. Scientific reports, 2017, 02-20, Volume: 7 Topics: Adaptor Proteins, Signal Transducing; Co-Repressor Proteins; Cullin Proteins; Cyclopentanes; Endothelial Cells; Gene Expression Regulation; Gene Knockdown Techniques; Human Umbilical Vein Endothelial Cells; Humans; Molecular Chaperones; Nuclear Proteins; Pyrimidines; Repressor Proteins; Signal Transduction; Vascular Endothelial Growth Factor Receptor-2	2017
CSN5/JAB1 suppresses the WNT inhibitor DKK1 in colorectal cancer cells. Cellular signalling, 2017, Volume: 34 Topics: beta Catenin; Cell Line, Tumor; Colorectal Neoplasms; COP9 Signalosome Complex; Cyclopentanes; Down-Regulation; HCT116 Cells; Humans; Intercellular Signaling Peptides and Proteins; Intracellular Signaling Peptides and Proteins; Peptide Hydrolases; Pyrimidines; Recombinant Proteins; RNA Interference; RNA, Messenger; RNA, Small Interfering; Wnt Proteins; Wnt Signaling Pathway	2017
MLN4924 and 2DG combined treatment enhances the efficiency of radiotherapy in breast cancer cells. International journal of radiation biology, 2017, Volume: 93, Issue:6 Topics: Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Breast Neoplasms; Chemoradiotherapy; Cyclopentanes; Deoxyglucose; Dose-Response Relationship, Drug; Dose-Response Relationship, Radiation; Humans; MCF-7 Cells; Pyrimidines; Radiotherapy Dosage; Treatment Outcome	2017
Assessment of Drug Sensitivity in Hematopoietic Stem and Progenitor Cells from Acute Myelogenous Leukemia and Myelodysplastic Syndrome Ex Vivo. Stem cells translational medicine, 2017, Volume: 6, Issue:3 Topics: Cell Count; Cell Death; Cell Survival; Cyclopentanes; Cytarabine; Hematopoietic Stem Cells; Humans; Leukemia, Myeloid, Acute; Myelodysplastic Syndromes; Pyrimidines	2017
Keap1/Cullin3 Modulates p62/SQSTM1 Activity via UBA Domain Ubiquitination. Cell reports, 2017, 04-04, Volume: 19, Issue:1 Topics: Amino Acid Substitution; Autophagy; Cells, Cultured; Cullin Proteins; Cyclopentanes; Humans; Inclusion Bodies; Intracellular Signaling Peptides and Proteins; Kelch-Like ECH-Associated Protein 1; Lysine; Microtubule-Associated Proteins; Protein Binding; Pyrimidines; Sequestosome-1 Protein; Ubiquitin; Ubiquitin-Protein Ligases; Ubiquitination	2017
Neural precursor cell expressed, developmentally downregulated 8‑activating enzyme inhibitor MLN4924 sensitizes colorectal cancer cells to oxaliplatin by inducing DNA damage, G2 cell cycle arrest and apoptosis. Molecular medicine reports, 2017, Volume: 15, Issue:5 Topics: Apoptosis; Cell Line, Tumor; Colorectal Neoplasms; Cyclopentanes; DNA Damage; G2 Phase Cell Cycle Checkpoints; Humans; NEDD8 Protein; Neoplasm Proteins; Organoplatinum Compounds; Pyridines; Pyrimidines	2017
NEDD8-activating enzyme inhibitor, MLN4924 (Pevonedistat) induces NOXA-dependent apoptosis through up-regulation of ATF-4. Biochemical and biophysical research communications, 2017, 06-17, Volume: 488, Issue:1 Topics: Activating Transcription Factor 4; Apoptosis; Cells, Cultured; Cyclopentanes; Dose-Response Relationship, Drug; Human Umbilical Vein Endothelial Cells; Humans; Molecular Structure; Proto-Oncogene Proteins c-bcl-2; Pyrimidines; Structure-Activity Relationship; Up-Regulation	2017
Inhibition of Neddylation Modification Sensitizes Pancreatic Cancer Cells to Gemcitabine. Neoplasia (New York, N.Y.), 2017, Volume: 19, Issue:6 Topics: Adenocarcinoma; Adult; Aged; Apoptosis; Carcinoma, Pancreatic Ductal; Cell Line, Tumor; Cell Proliferation; Cyclopentanes; Deoxycytidine; Female; Gemcitabine; Gene Expression Regulation, Neoplastic; Humans; Male; Middle Aged; NEDD8 Protein; Pyrimidines; Ubiquitin-Activating Enzymes; Ubiquitins; Xenograft Model Antitumor Assays	2017
Promoting tumorigenesis in nasopharyngeal carcinoma, NEDD8 serves as a potential theranostic target. Cell death & disease, 2017, 06-01, Volume: 8, Issue:6 Topics: Adult; Animals; Antineoplastic Agents; Apoptosis; Carcinogenesis; Carcinoma; Cell Cycle Checkpoints; Cell Line, Tumor; Cell Proliferation; Cisplatin; Cyclopentanes; Female; Gamma Rays; Gene Expression Regulation, Neoplastic; Humans; JNK Mitogen-Activated Protein Kinases; Lymphatic Metastasis; Male; Mice; Mice, Nude; Middle Aged; Molecular Targeted Therapy; Nasopharyngeal Carcinoma; Nasopharyngeal Neoplasms; NEDD8 Protein; Neoplastic Stem Cells; Pyrimidines; RNA, Small Interfering; Signal Transduction; Survival Analysis; Xenograft Model Antitumor Assays	2017
Dissecting the Specificity of Adenosyl Sulfamate Inhibitors Targeting the Ubiquitin-Activating Enzyme. Structure (London, England : 1993), 2017, 07-05, Volume: 25, Issue:7 Topics: Binding Sites; Cyclopentanes; Enzyme Inhibitors; Humans; Mutation; Nucleosides; Protein Binding; Pyrazoles; Pyrimidines; Quantitative Structure-Activity Relationship; Saccharomyces cerevisiae Proteins; Substrate Specificity; Sulfides; Sulfonamides; Ubiquitin-Activating Enzymes	2017
Inhibition of Mcl-1 enhances Pevonedistat-triggered apoptosis in osteosarcoma cells. Experimental cell research, 2017, 09-15, Volume: 358, Issue:2 Topics: Antineoplastic Agents; Apoptosis; Caspase 3; Cell Line, Tumor; Cell Proliferation; Cell Survival; Cyclopentanes; Humans; Myeloid Cell Leukemia Sequence 1 Protein; Osteosarcoma; Proto-Oncogene Proteins c-bcl-2; Pyrimidines	2017
Targeting neddylation pathway with MLN4924 (Pevonedistat) induces NOXA-dependent apoptosis in renal cell carcinoma. Biochemical and biophysical research communications, 2017, 09-02, Volume: 490, Issue:4 Topics: Antineoplastic Agents; Apoptosis; Carcinoma, Renal Cell; Cell Survival; Cyclopentanes; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Humans; Kidney Neoplasms; Proto-Oncogene Proteins c-bcl-2; Pyrimidines; Structure-Activity Relationship; Tumor Cells, Cultured; Up-Regulation	2017
Effects of the NEDD8-Activating Enzyme Inhibitor MLN4924 on Lytic Reactivation of Kaposi's Sarcoma-Associated Herpesvirus. Journal of virology, 2017, 10-01, Volume: 91, Issue:19 Topics: Antigens, Viral; Butyric Acid; Cell Line, Tumor; Cell Proliferation; Cyclopentanes; HEK293 Cells; Herpesvirus 8, Human; Humans; Immediate-Early Proteins; Immunoglobulin J Recombination Signal Sequence-Binding Protein; Nuclear Proteins; Promoter Regions, Genetic; Pyrimidines; Sarcoma, Kaposi; Tetradecanoylphorbol Acetate; Trans-Activators; Ubiquitin-Activating Enzymes; Virus Activation	2017
MLN4924 (Pevonedistat), a protein neddylation inhibitor, suppresses proliferation and migration of human clear cell renal cell carcinoma. Scientific reports, 2017, 07-17, Volume: 7, Issue:1 Topics: Apoptosis; Autophagy; Carcinoma, Renal Cell; Cell Cycle Checkpoints; Cell Movement; Cell Proliferation; Cyclopentanes; Enzyme Inhibitors; Gene Expression Regulation, Neoplastic; Humans; Kidney Neoplasms; NEDD8 Protein; Protein Processing, Post-Translational; Proteolysis; Pyrimidines; Tumor Cells, Cultured; Ubiquitins	2017
The Neddylation Inhibitor Pevonedistat (MLN4924) Suppresses and Radiosensitizes Head and Neck Squamous Carcinoma Cells and Tumors. Molecular cancer therapeutics, 2018, Volume: 17, Issue:2 Topics: Animals; Cyclopentanes; Female; Gene Silencing; Humans; Mice; Mice, Nude; Pyrimidines; Radiation-Sensitizing Agents; Squamous Cell Carcinoma of Head and Neck; Transfection; Xenograft Model Antitumor Assays	2018
Inhibition of constitutive NF-κB activity induces platelet apoptosis via ER stress. Biochemical and biophysical research communications, 2017, 12-02, Volume: 493, Issue:4 Topics: Apoptosis; bcl-2-Associated X Protein; Blood Platelets; Calcium; Cyclopentanes; Endoplasmic Reticulum Stress; Humans; Membrane Potential, Mitochondrial; NF-kappa B; Nitriles; Proto-Oncogene Proteins c-bcl-2; Pyrimidines; Sarcoplasmic Reticulum Calcium-Transporting ATPases; Sulfones	2017
Inhibition of neddylation by MLN4924 improves neointimal hyperplasia and promotes apoptosis of vascular smooth muscle cells through p53 and p62. Cell death and differentiation, 2018, Volume: 25, Issue:2 Topics: Animals; Apoptosis; Cells, Cultured; Cyclopentanes; Enzyme Inhibitors; HEK293 Cells; Humans; Hyperplasia; Male; Membrane Glycoproteins; Mice; Mice, Inbred C57BL; Muscle, Smooth, Vascular; Nuclear Pore Complex Proteins; Pyrimidines; Tumor Suppressor Protein p53	2018
Chk1 inhibitor SCH 900776 enhances the antitumor activity of MLN4924 on pancreatic cancer. Cell cycle (Georgetown, Tex.), 2018, Volume: 17, Issue:2 Topics: Adult; Aged; Aged, 80 and over; Animals; Antineoplastic Combined Chemotherapy Protocols; Cell Line, Tumor; Checkpoint Kinase 1; Cyclopentanes; DNA Damage; DNA Replication; Drug Synergism; Female; G2 Phase Cell Cycle Checkpoints; Humans; Male; Mice, Nude; Middle Aged; Pancreatic Neoplasms; Prognosis; Protein Kinase Inhibitors; Pyrazoles; Pyrimidines; Ubiquitin-Activating Enzymes	2018
Roles of neddylation against viral infections. Cellular & molecular immunology, 2018, Volume: 15, Issue:3 Topics: Animals; Cyclopentanes; Humans; Immunity, Innate; Interferon Regulatory Factor-3; Interferon Type I; Mice; Mice, Knockout; NEDD8 Protein; NF-kappa B; Pyrimidines; Species Specificity; Ubiquitin-Protein Ligases; Ubiquitination; Virus Diseases; Viruses	2018
Inhibition of neddylation pathway represses influenza virus replication and pro-inflammatory responses. Virology, 2018, 01-15, Volume: 514 Topics: Animals; Antiviral Agents; Cyclopentanes; Cytokines; Female; Humans; Influenza A Virus, H1N1 Subtype; Influenza A Virus, H9N2 Subtype; Influenza, Human; Mice; Mice, Inbred BALB C; NF-kappa B; Protein Processing, Post-Translational; Pyrimidines; Ubiquitin-Conjugating Enzymes; Virus Replication	2018
Inhibition of neddylation facilitates cell migration through enhanced phosphorylation of caveolin-1 in PC3 and U373MG cells. BMC cancer, 2018, 01-05, Volume: 18, Issue:1 Topics: Caveolin 1; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cyclopentanes; Humans; Male; NEDD8 Protein; Phosphorylation; Prostatic Neoplasms; Proteolysis; Pyrimidines; Signal Transduction; Ubiquitin-Activating Enzymes	2018
Antitumor Effects of Blocking Protein Neddylation in T315I-BCR-ABL Leukemia Cells and Leukemia Stem Cells. Cancer research, 2018, 03-15, Volume: 78, Issue:6 Topics: Animals; Antigens, CD34; Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cyclopentanes; Drug Resistance, Neoplasm; Fusion Proteins, bcr-abl; Humans; Imatinib Mesylate; Leukemia, Experimental; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Male; Mice, Inbred C57BL; Molecular Targeted Therapy; Neoplastic Stem Cells; Point Mutation; Pyrimidines; Ubiquitin-Activating Enzymes	2018
The SKP1-Cullin-F-box E3 ligase βTrCP and CDK2 cooperate to control STIL abundance and centriole number. Open biology, 2018, Volume: 8, Issue:2 Topics: beta-Transducin Repeat-Containing Proteins; Centrioles; Cyclin-Dependent Kinase 2; Cyclopentanes; HEK293 Cells; Homeostasis; Humans; Interphase; Intracellular Signaling Peptides and Proteins; Mutation; Phosphorylation; Proteolysis; Proteomics; Pyrimidines; Serine; SKP Cullin F-Box Protein Ligases	2018
Pevonedistat, a new partner for 5-azacitidine. Blood, 2018, 03-29, Volume: 131, Issue:13 Topics: Azacitidine; Cyclopentanes; Enzyme Inhibitors; Humans; Leukemia, Myeloid, Acute; NEDD8 Protein; Pyrimidines	2018
A first-in-class inhibitor, MLN4924 (pevonedistat), induces cell-cycle arrest, senescence, and apoptosis in human renal cell carcinoma by suppressing UBE2M-dependent neddylation modification. Cancer chemotherapy and pharmacology, 2018, Volume: 81, Issue:6 Topics: Animals; Antineoplastic Agents; Apoptosis; Carcinoma, Renal Cell; Cell Cycle Checkpoints; Cell Line, Tumor; Cell Proliferation; Cellular Senescence; Cyclopentanes; DNA Damage; Dose-Response Relationship, Drug; Flow Cytometry; Humans; Kidney Neoplasms; Mice; Mice, Inbred BALB C; Pyrimidines; Ubiquitin-Activating Enzymes; Ubiquitin-Conjugating Enzymes; Xenograft Model Antitumor Assays	2018
Uncovering inherent cellular plasticity of multiciliated ependyma leading to ventricular wall transformation and hydrocephalus. Nature communications, 2018, 04-25, Volume: 9, Issue:1 Topics: Animals; Cell Dedifferentiation; Cell Plasticity; Cells, Cultured; Cilia; Cyclopentanes; Ependyma; Forkhead Transcription Factors; HEK293 Cells; Humans; Hydrocephalus; I-kappa B Kinase; Mice; Mice, Knockout; Neurogenesis; Neuroglia; Neurons; Primary Cell Culture; Pyrimidines; Signal Transduction	2018
The E3 ligase C-CBL inhibits cancer cell migration by neddylating the proto-oncogene c-Src. Oncogene, 2018, Volume: 37, Issue:41 Topics: Cell Line, Tumor; Cell Movement; Cyclopentanes; Enzyme Inhibitors; Genes, src; Genes, Tumor Suppressor; Glioblastoma; Humans; Lung Neoplasms; NEDD8 Protein; Neoplasms; Proto-Oncogene Mas; Proto-Oncogene Proteins c-cbl; Pyrimidines	2018
UBE2M Is a Stress-Inducible Dual E2 for Neddylation and Ubiquitylation that Promotes Targeted Degradation of UBE2F. Molecular cell, 2018, 06-21, Volume: 70, Issue:6 Topics: Animals; Cell Line; Cell Line, Tumor; Cullin Proteins; Cyclopentanes; Female; HEK293 Cells; Humans; Mice; Mice, Inbred BALB C; Mice, Nude; Pyrimidines; Stress, Physiological; Ubiquitin-Activating Enzymes; Ubiquitin-Conjugating Enzymes; Ubiquitin-Protein Ligases; Ubiquitination; Ubiquitins	2018
The replication initiation determinant protein (RepID) modulates replication by recruiting CUL4 to chromatin. Nature communications, 2018, 07-17, Volume: 9, Issue:1 Topics: Cell Cycle; Cell Line, Tumor; Chromatin; Cullin Proteins; Cyclopentanes; DNA Replication; Gene Expression; HCT116 Cells; Humans; Intracellular Signaling Peptides and Proteins; K562 Cells; Osteoblasts; Protein Binding; Protein Transport; Pyrimidines; Replication Origin; S-Phase Kinase-Associated Proteins; Stem Cell Factor; Ubiquitin-Protein Ligases	2018
Analysis of MLN4924 (pevonedistat) as a potential therapeutic agent in malignant melanoma. Melanoma research, 2018, Volume: 28, Issue:5 Topics: Cell Line, Tumor; Cyclopentanes; Enzyme Inhibitors; Humans; Melanoma; Pyrimidines; Skin Neoplasms; Survival Rate	2018
A genome-scale CRISPR-Cas9 screening in myeloma cells identifies regulators of immunomodulatory drug sensitivity. Leukemia, 2019, Volume: 33, Issue:1 Topics: Adaptor Proteins, Signal Transducing; Antineoplastic Agents; Biomarkers, Tumor; Bortezomib; COP9 Signalosome Complex; CRISPR-Cas Systems; Cyclopentanes; Enzyme Inhibitors; Gene Expression Regulation, Neoplastic; Humans; Ikaros Transcription Factor; Immunologic Factors; Multiple Myeloma; Peptide Hydrolases; Prognosis; Proteolysis; Pyrimidines; Tumor Cells, Cultured; Ubiquitin-Protein Ligases; Ubiquitination	2019
Targeting NEDD8-activating enzyme is a new approach to treat canine diffuse large B-cell lymphoma. Veterinary and comparative oncology, 2018, Volume: 16, Issue:4 Topics: Animals; Antineoplastic Agents; Apoptosis; Blotting, Western; Cell Line, Tumor; Cell Proliferation; Cyclopentanes; Dog Diseases; Dogs; Dose-Response Relationship, Drug; Inhibitory Concentration 50; Lymphoma, Large B-Cell, Diffuse; Mice; Mice, Inbred NOD; NEDD8 Protein; Neoplasm Transplantation; Pyrimidines; Reverse Transcriptase Polymerase Chain Reaction; Ubiquitin-Activating Enzymes	2018
AKT inhibitor MK-2206 sensitizes breast cancer cells to MLN4924, a first-in-class NEDD8-activating enzyme (NAE) inhibitor. Cell cycle (Georgetown, Tex.), 2018, Volume: 17, Issue:16 Topics: Apoptosis; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Cell Survival; Cyclopentanes; Female; Heterocyclic Compounds, 3-Ring; Humans; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Pyrimidines; Signal Transduction; Ubiquitin-Activating Enzymes	2018
Systematic analysis of synergistic proteome modulations in a drug combination of cisplatin and MLN4924. Molecular omics, 2018, 12-03, Volume: 14, Issue:6 Topics: Apoptosis; Cell Line, Tumor; Cell Survival; Chromatography, Liquid; Cisplatin; Cyclopentanes; DNA Damage; Dose-Response Relationship, Drug; Drug Combinations; Drug Synergism; Humans; Oxidative Stress; Proteome; Proteomics; Pyrimidines; Reactive Oxygen Species; Tandem Mass Spectrometry	2018
The Nedd8-activating enzyme inhibitor MLN4924 (TAK-924/Pevonedistat) induces apoptosis via c-Myc-Noxa axis in head and neck squamous cell carcinoma. Cell proliferation, 2019, Volume: 52, Issue:2 Topics: Apoptosis; Cell Cycle Checkpoints; Cell Line, Tumor; Cyclopentanes; Enzyme Inhibitors; Head and Neck Neoplasms; Humans; NEDD8 Protein; Proto-Oncogene Proteins c-bcl-2; Proto-Oncogene Proteins c-myc; Pyrimidines; Signal Transduction; Squamous Cell Carcinoma of Head and Neck	2019
Inhibition of Skp1-Cullin-F-box complexes during bovine oocyte maturation and preimplantation development leads to delayed development of embryos†. Biology of reproduction, 2019, 04-01, Volume: 100, Issue:4 Topics: Animals; Blastocyst; Cattle; Cells, Cultured; Cyclopentanes; Embryo, Mammalian; Embryonic Development; Female; In Vitro Oocyte Maturation Techniques; Multiprotein Complexes; Oocytes; Oogenesis; Pyrimidines; SKP Cullin F-Box Protein Ligases; Time Factors	2019
Disruption of protein neddylation with MLN4924 attenuates paclitaxel-induced apoptosis and microtubule polymerization in ovarian cancer cells. Biochemical and biophysical research communications, 2019, 01-15, Volume: 508, Issue:3 Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Cell Line, Tumor; Cell Proliferation; Cyclopentanes; Drug Resistance, Neoplasm; Female; Humans; Microtubules; NEDD8 Protein; Ovarian Neoplasms; Paclitaxel; Polymerization; Protein Processing, Post-Translational; Pyrimidines; Ubiquitin-Conjugating Enzymes	2019
MRFAP1 plays a protective role in neddylation inhibitor MLN4924-mediated gastric cancer cell death. European review for medical and pharmacological sciences, 2018, Volume: 22, Issue:23 Topics: Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cell Proliferation; Cyclopentanes; Enzyme Inhibitors; G2 Phase Cell Cycle Checkpoints; Gene Expression Regulation, Neoplastic; Humans; Intracellular Signaling Peptides and Proteins; Nuclear Proteins; Pyrimidines; Signal Transduction; Stomach Neoplasms; Ubiquitin-Activating Enzymes; Ubiquitination	2018
Pevonedistat, a Neuronal Precursor Cell-Expressed Developmentally Down-Regulated Protein 8-Activating Enzyme Inhibitor, Is a Potent Inhibitor of Hepatitis B Virus. Hepatology (Baltimore, Md.), 2019, Volume: 69, Issue:5 Topics: Cell Cycle Proteins; Chromosomal Proteins, Non-Histone; Cyclopentanes; Drug Evaluation, Preclinical; HEK293 Cells; Hep G2 Cells; Hepatitis B; Hepatitis B virus; Humans; Primary Cell Culture; Pyrimidines; Ubiquitin-Activating Enzymes; Ubiquitin-Protein Ligases; Virus Replication	2019
MLN4924, a Protein Neddylation Inhibitor, Suppresses the Growth of Human Chondrosarcoma through Inhibiting Cell Proliferation and Inducing Endoplasmic Reticulum Stress-Related Apoptosis. International journal of molecular sciences, 2018, Dec-24, Volume: 20, Issue:1 Topics: Animals; Apoptosis; Bone Neoplasms; Caspase 3; Cell Line, Tumor; Cell Proliferation; Chondrosarcoma; Cyclopentanes; Endoplasmic Reticulum Chaperone BiP; Endoplasmic Reticulum Stress; Enzyme Inhibitors; G2 Phase Cell Cycle Checkpoints; Heat-Shock Proteins; Histones; Humans; Mice; Mice, Nude; NEDD8 Protein; Phosphorylation; Pyrimidines; Transcription Factor CHOP; Transplantation, Heterologous	2018
Inhibiting neddylation modification alters mitochondrial morphology and reprograms energy metabolism in cancer cells. JCI insight, 2019, 02-21, Volume: 4, Issue:4 Topics: Animals; Apoptosis; Cell Line, Tumor; Cell Proliferation; Cell Survival; Cyclopentanes; Energy Metabolism; Female; GTP Phosphohydrolases; HEK293 Cells; Humans; Metformin; Mice; Mitochondria; Mitochondrial Dynamics; Mitochondrial Membrane Transport Proteins; Naphthoquinones; Neoplasms; Oxidative Phosphorylation; Proteolysis; Pyrimidines; Ubiquitin-Activating Enzymes; Ubiquitination; Xenograft Model Antitumor Assays	2019
Neddylation Inactivation Facilitates FOXO3a Nuclear Export to Suppress Estrogen Receptor Transcription and Improve Fulvestrant Sensitivity. Clinical cancer research : an official journal of the American Association for Cancer Research, 2019, 06-15, Volume: 25, Issue:12 Topics: Active Transport, Cell Nucleus; Animals; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Cyclopentanes; Disease-Free Survival; Drug Resistance, Neoplasm; Enzyme Inhibitors; Estrogen Receptor alpha; Estrogen Receptor Antagonists; Female; Forkhead Box Protein O3; Fulvestrant; Humans; Mice; Mice, Inbred BALB C; Mice, Nude; NEDD8 Protein; Pyrimidines; Ubiquitin-Activating Enzymes; Ubiquitins; Xenograft Model Antitumor Assays	2019
The Selection of NFκB Inhibitors to Block Inflammation and Induce Sensitisation to FasL-Induced Apoptosis in HNSCC Cell Lines Is Critical for Their Use as a Prospective Cancer Therapy. International journal of molecular sciences, 2019, Mar-15, Volume: 20, Issue:6 Topics: Amides; Anti-Inflammatory Agents; Cell Line, Tumor; Cell Proliferation; Cyclopentanes; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Drug Synergism; Fas Ligand Protein; Head and Neck Neoplasms; Humans; Hydrocortisone; Interleukin-8; NF-kappa B; Phenyl Ethers; Pyrimidines; Quinazolines; Signal Transduction; Squamous Cell Carcinoma of Head and Neck; Thiophenes; Tumor Necrosis Factor-alpha	2019
MLN4924 protects against interleukin-17A-induced pulmonary inflammation by disrupting ACT1-mediated signaling. American journal of physiology. Lung cellular and molecular physiology, 2019, 06-01, Volume: 316, Issue:6 Topics: Adaptor Proteins, Signal Transducing; Animals; Cell Line; Chemokine CXCL1; Cyclopentanes; Disease Models, Animal; Enzyme Inhibitors; Humans; Hypertension, Pulmonary; Interleukin-17; Interleukin-1beta; Interleukin-6; Male; Mice; Mice, Inbred C57BL; NF-kappa B; Pneumonia; Pulmonary Disease, Chronic Obstructive; Pyrimidines; TNF Receptor-Associated Factor 6; Ubiquitination	2019
Transient inhibition of neddylation at neonatal stage evokes reversible cardiomyopathy and predisposes the heart to isoproterenol-induced heart failure. American journal of physiology. Heart and circulatory physiology, 2019, 06-01, Volume: 316, Issue:6 Topics: Animals; Animals, Newborn; Cell Proliferation; Cells, Cultured; Cyclopentanes; Disease Models, Animal; Heart Failure; Hypertrophy, Left Ventricular; Isoproterenol; Myocytes, Cardiac; NEDD8 Protein; Pyrimidines; Rats, Sprague-Dawley; Ubiquitin-Conjugating Enzymes; Ubiquitination; Ventricular Function, Left; Ventricular Remodeling	2019
Mitotic replisome disassembly depends on TRAIP ubiquitin ligase activity. Life science alliance, 2019, Volume: 2, Issue:2 Topics: Animals; Aphidicolin; Caffeine; Chromatin; Cyclins; Cyclopentanes; DNA Replication; Female; Male; Minichromosome Maintenance Complex Component 7; Mitosis; Ovum; Pyrimidines; Small Ubiquitin-Related Modifier Proteins; Spermatozoa; Ubiquitin-Conjugating Enzymes; Ubiquitin-Protein Ligases; Ubiquitination; Valosin Containing Protein; Xenopus laevis; Xenopus Proteins	2019
Inhibition of neddylation modification by MLN4924 sensitizes hepatocellular carcinoma cells to sorafenib. Oncology reports, 2019, Volume: 41, Issue:6 Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Carcinoma, Hepatocellular; Cell Movement; Cell Proliferation; Cyclopentanes; Female; Gene Expression Regulation, Neoplastic; Humans; Liver Neoplasms; Male; Mice; Middle Aged; NEDD8 Protein; Neoplasm Proteins; NF-KappaB Inhibitor alpha; Pyrimidines; Sorafenib; Ubiquitin-Activating Enzymes; Ubiquitins; Xenograft Model Antitumor Assays	2019
Neddylation inhibition upregulates PD-L1 expression and enhances the efficacy of immune checkpoint blockade in glioblastoma. International journal of cancer, 2019, 08-01, Volume: 145, Issue:3 Topics: Animals; B7-H1 Antigen; Brain Neoplasms; Cell Line, Tumor; Cullin Proteins; Cyclopentanes; Enzyme Inhibitors; F-Box-WD Repeat-Containing Protein 7; Female; Glioblastoma; Humans; Mice; Mice, Inbred C57BL; Mice, Nude; Protein Processing, Post-Translational; Proto-Oncogene Proteins c-myc; Pyrimidines; Random Allocation; T-Lymphocytes; Ubiquitin-Activating Enzymes; Ubiquitin-Conjugating Enzymes; Up-Regulation; Xenograft Model Antitumor Assays	2019
Inhibition of neddylation induces mitotic defects and alters MKLP1 accumulation at the midbody during cytokinesis. Cell cycle (Georgetown, Tex.), 2019, Volume: 18, Issue:10 Topics: Cell Cycle Proteins; COP9 Signalosome Complex; Cyclopentanes; G2 Phase Cell Cycle Checkpoints; HeLa Cells; Humans; Microtubule-Associated Proteins; Mitosis; NEDD8 Protein; Pyrimidines	2019
Inhibition of neddylation causes meiotic arrest in mouse oocyte. Cell cycle (Georgetown, Tex.), 2019, Volume: 18, Issue:11 Topics: Animals; Antibodies, Monoclonal; Cell Cycle Checkpoints; Cells, Cultured; Cyclopentanes; Down-Regulation; Female; Meiosis; Mice; Mice, Inbred ICR; NEDD8 Protein; Oocytes; Oogenesis; Protein Processing, Post-Translational; Pyrimidines; RNA, Small Interfering; Ubiquitination	2019
Targeting neddylation inhibits intravascular survival and extravasation of cancer cells to prevent lung-cancer metastasis. Cell biology and toxicology, 2019, Volume: 35, Issue:3 Topics: Animals; Apoptosis; Cell Cycle Checkpoints; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cyclopentanes; Gene Expression Regulation, Neoplastic; Humans; Lung Neoplasms; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Mice; Mice, Inbred BALB C; Mice, Nude; NEDD8 Protein; Neoplasm Invasiveness; Neoplasm Metastasis; Protein Processing, Post-Translational; Pyrimidines; Signal Transduction; Ubiquitin-Activating Enzymes; Vimentin; Xenograft Model Antitumor Assays	2019
CSN5 inhibition triggers inflammatory signaling and Rho/ROCK-dependent loss of endothelial integrity. Scientific reports, 2019, 05-31, Volume: 9, Issue:1 Topics: Animals; COP9 Signalosome Complex; Cyclopentanes; Endothelium, Vascular; Gene Expression Regulation; Green Fluorescent Proteins; HEK293 Cells; Human Umbilical Vein Endothelial Cells; Humans; Inflammation; Intercellular Adhesion Molecule-1; Intracellular Signaling Peptides and Proteins; Neutrophils; NF-kappa B p50 Subunit; NF-KappaB Inhibitor alpha; Peptide Hydrolases; Pyrimidines; rho-Associated Kinases; rhoA GTP-Binding Protein; rhoB GTP-Binding Protein; Ubiquitin; Up-Regulation; Zebrafish	2019
MLN4924 Exerts a Neuroprotective Effect against Oxidative Stress via Sirt1 in Spinal Cord Ischemia-Reperfusion Injury. Oxidative medicine and cellular longevity, 2019, Volume: 2019 Topics: Animals; Cyclopentanes; Enzyme Inhibitors; Male; Neurons; Neuroprotective Agents; Oxidative Stress; Pyrimidines; Random Allocation; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Sirtuin 1; Spinal Cord Ischemia	2019
Validation of NEDD8-conjugating enzyme UBC12 as a new therapeutic target in lung cancer. EBioMedicine, 2019, Volume: 45 Topics: A549 Cells; Animals; Apoptosis; Cell Proliferation; China; Cyclopentanes; Female; Gene Expression Regulation, Neoplastic; Gene Knockdown Techniques; Heterografts; Humans; Lung Neoplasms; Male; Mice; Molecular Targeted Therapy; NEDD8 Protein; Proteomics; Pyrimidines; Signal Transduction; Ubiquitin-Conjugating Enzymes; Ubiquitins	2019
The Bardet-Biedl syndrome protein complex regulates cell migration and tissue repair through a Cullin-3/RhoA pathway. American journal of physiology. Cell physiology, 2019, 09-01, Volume: 317, Issue:3 Topics: Animals; Bardet-Biedl Syndrome; Cell Movement; Cells, Cultured; Cullin Proteins; Cyclopentanes; Enzyme Inhibitors; Female; Gene Knock-In Techniques; Humans; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Microtubule-Associated Proteins; Pyrimidines; rhoA GTP-Binding Protein; Signal Transduction	2019
Neddylation Facilitates the Antiviral Response in Zebrafish. Frontiers in immunology, 2019, Volume: 10 Topics: Animals; Cell Line; Cyclopentanes; Fish Diseases; NEDD8 Protein; Pyrimidines; Rhabdoviridae; Rhabdoviridae Infections; Signal Transduction; Ubiquitination; Zebrafish; Zebrafish Proteins	2019
Adenovirus oncoprotein E4orf6 triggers Cullin5 neddylation to activate the CLR5 E3 ligase for p53 degradation. Biochemical and biophysical research communications, 2019, 09-03, Volume: 516, Issue:4 Topics: Adenoviridae; Adenovirus E4 Proteins; Cullin Proteins; Cyclopentanes; Down-Regulation; Endopeptidases; Gene Expression Regulation; HEK293 Cells; Humans; Pyrimidines; Signal Transduction; Tumor Suppressor Protein p53; Ubiquitin-Conjugating Enzymes; Ubiquitin-Protein Ligases	2019
The NEDD8-activating enzyme inhibitor MLN4924 induces DNA damage in Ph+ leukemia and sensitizes for ABL kinase inhibitors. Cell cycle (Georgetown, Tex.), 2019, Volume: 18, Issue:18 Topics: Apoptosis; Cell Line, Tumor; Cyclopentanes; DNA Damage; Drug Resistance, Neoplasm; Drug Synergism; Drug Therapy, Combination; Fusion Proteins, bcr-abl; Humans; Imatinib Mesylate; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Myeloid Cell Leukemia Sequence 1 Protein; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-bcl-2; Pyrimidines; S Phase Cell Cycle Checkpoints; Signal Transduction; Ubiquitin-Activating Enzymes	2019
Population pharmacokinetics of pevonedistat alone or in combination with standard of care in patients with solid tumours or haematological malignancies. British journal of clinical pharmacology, 2019, Volume: 85, Issue:11 Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Biological Variation, Population; Clinical Trials as Topic; Cyclopentanes; Drug Interactions; Drugs, Investigational; Female; Hematologic Neoplasms; Humans; Male; Metabolic Clearance Rate; Middle Aged; Pyrimidines; Reference Values; Standard of Care; Young Adult	2019
The NEDD8-activating enzyme inhibitor MLN4924 sensitizes a TNFR1 Cell death & disease, 2019, 08-13, Volume: 10, Issue:8 Topics: Adult; Aged; Apoptosis; Bortezomib; Cell Line, Tumor; Cell Survival; Cyclopentanes; Female; Humans; Male; Middle Aged; Multiple Myeloma; Necrosis; NF-kappa B; Oligopeptides; Pyrimidines; Receptors, Tumor Necrosis Factor, Type I; Signal Transduction; Tumor Necrosis Factor-alpha; Ubiquitin-Activating Enzymes	2019
Proteomics identifies neddylation as a potential therapy target in small intestinal neuroendocrine tumors. Oncogene, 2019, Volume: 38, Issue:43 Topics: Aged; Apoptosis; Carrier Proteins; Cell Line, Tumor; Cyclopentanes; Female; Humans; Intestinal Neoplasms; Intestine, Small; Male; Middle Aged; NEDD8 Protein; Neuroendocrine Tumors; Proliferating Cell Nuclear Antigen; Proteomics; Pyrimidines; RNA, Small Interfering; Ubiquitins	2019
Discovery of Novel Pyrazolo-pyridone DCN1 Inhibitors Controlling Cullin Neddylation. Journal of medicinal chemistry, 2019, 09-26, Volume: 62, Issue:18 Topics: Amides; Carcinoma, Squamous Cell; Cell Line, Tumor; Cell Proliferation; Cullin Proteins; Cyclopentanes; Drug Design; Fibroblasts; Glycine; Humans; Intracellular Signaling Peptides and Proteins; NEDD8 Protein; Protein Domains; Protein Interaction Mapping; Pyrazoles; Pyridones; Pyrimidines; Reactive Oxygen Species; Structure-Activity Relationship; Ubiquitin-Conjugating Enzymes	2019
The FBXW2-MSX2-SOX2 axis regulates stem cell property and drug resistance of cancer cells. Proceedings of the National Academy of Sciences of the United States of America, 2019, 10-08, Volume: 116, Issue:41 Topics: Animals; Antineoplastic Agents, Hormonal; Apoptosis; Cell Proliferation; Cyclopentanes; Drug Resistance, Neoplasm; Enzyme Inhibitors; F-Box Proteins; Female; Gene Expression Regulation, Neoplastic; Homeodomain Proteins; Humans; Lung Neoplasms; Mice; Mice, Inbred BALB C; Mice, Knockout; Mice, Nude; Neoplastic Stem Cells; Prognosis; Pyrimidines; SOXB1 Transcription Factors; Survival Rate; Tamoxifen; Tumor Cells, Cultured; Ubiquitination; Xenograft Model Antitumor Assays	2019
Pevonedistat targeted therapy inhibits canine melanoma cell growth through induction of DNA re-replication and senescence. Veterinary and comparative oncology, 2020, Volume: 18, Issue:3 Topics: Animals; Apoptosis; Cell Line, Tumor; Cell Survival; Cyclopentanes; DNA Replication; Dog Diseases; Dogs; Enzyme Inhibitors; Melanoma; Mouth Neoplasms; Pyrimidines	2020
SCF Cellular signalling, 2020, Volume: 65 Topics: Antineoplastic Agents; Cell Line; Chromatography, Liquid; Cullin Proteins; Cyclopentanes; Cysteine Proteinase Inhibitors; Enzyme Inhibitors; F-Box Proteins; Humans; Leupeptins; Proteasome Endopeptidase Complex; Proteome; Pyrimidines; Signal Transduction; SKP Cullin F-Box Protein Ligases; Tandem Mass Spectrometry; Transcriptional Activation; Ubiquitination	2020
The Identification of Potential Therapeutic Targets for Cutaneous Squamous Cell Carcinoma. The Journal of investigative dermatology, 2020, Volume: 140, Issue:6 Topics: Carcinoma, Squamous Cell; Cell Cycle Proteins; Cell Line, Tumor; Cyclopentanes; Drug Screening Assays, Antitumor; Endopeptidases; Endosomal Sorting Complexes Required for Transport; F-Box Proteins; Gene Knockdown Techniques; Humans; Molecular Targeted Therapy; Nuclear Proteins; Pyrimidines; RNA, Small Interfering; Skin Neoplasms; Ubiquitin Thiolesterase; Ubiquitin-Activating Enzymes	2020
Targeting oncogenic SOX2 in human cancer cells: therapeutic application. Protein & cell, 2020, Volume: 11, Issue:2 Topics: Antineoplastic Agents; Cyclopentanes; Humans; Neoplasms; Neoplastic Stem Cells; Pyrimidines; SOXB1 Transcription Factors	2020
Genome-Wide Small Interfering RNA Screening Reveals a Role for Cullin3-Really Interesting New Gene Ligase Signaling in Heterologous Sensitization of Adenylyl Cyclase. The Journal of pharmacology and experimental therapeutics, 2020, Volume: 372, Issue:3 Topics: Adenylyl Cyclase Inhibitors; Adenylyl Cyclases; Carrier Proteins; Cell Survival; Cullin Proteins; Cyclic AMP; Cyclopentanes; Enzyme Activation; Gene Knockdown Techniques; Genome-Wide Association Study; HEK293 Cells; Humans; NEDD8 Protein; Pyrimidines; Receptors, Dopamine D2; RNA, Small Interfering; Signal Transduction; Ubiquitin-Protein Ligases	2020
Effective targeting of the ubiquitin-like modifier NEDD8 for lung adenocarcinoma treatment. Cell biology and toxicology, 2020, Volume: 36, Issue:4 Topics: Adenocarcinoma of Lung; Cell Cycle Checkpoints; Cell Line, Tumor; Cell Proliferation; Cyclopentanes; Humans; Lung Neoplasms; NEDD8 Protein; Pyrimidines; Signal Transduction; Ubiquitin	2020
Overexpression of ABCG2 confers resistance to pevonedistat, an NAE inhibitor. Experimental cell research, 2020, 03-15, Volume: 388, Issue:2 Topics: ATP Binding Cassette Transporter, Subfamily G, Member 2; Cyclopentanes; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Enzyme Inhibitors; Humans; Neoplasm Proteins; Neoplasms; Pyrimidines; Tumor Cells, Cultured; Ubiquitin-Activating Enzymes	2020
Proteome Instability Is a Therapeutic Vulnerability in Mismatch Repair-Deficient Cancer. Cancer cell, 2020, 03-16, Volume: 37, Issue:3 Topics: Animals; Cell Line, Tumor; Colorectal Neoplasms; Cyclopentanes; DNA Mismatch Repair; Endometrial Neoplasms; Female; HCT116 Cells; Humans; Immunotherapy; Mice, Inbred C57BL; Mice, Transgenic; Microsatellite Instability; Mutation; NEDD8 Protein; Programmed Cell Death 1 Receptor; Protein Stability; Proteome; Pyrimidines; Xenograft Model Antitumor Assays	2020
Neddylation inactivation represses androgen receptor transcription and inhibits growth, survival and invasion of prostate cancer cells. Neoplasia (New York, N.Y.), 2020, Volume: 22, Issue:4 Topics: Animals; Apoptosis; Cell Line, Tumor; Cell Proliferation; Cell Survival; Cyclopentanes; Gene Expression Regulation, Neoplastic; Humans; Male; Mice; Models, Biological; Protein Processing, Post-Translational; Pyrimidines; Receptors, Androgen; Transcription, Genetic	2020
Abnormal Cullin1 neddylation-mediated p21 accumulation participates in the pathogenesis of recurrent spontaneous abortion by regulating trophoblast cell proliferation and differentiation. Molecular human reproduction, 2020, 05-15, Volume: 26, Issue:5 Topics: Abortion, Habitual; Case-Control Studies; Cell Differentiation; Cell Proliferation; Cells, Cultured; Cullin Proteins; Cyclin-Dependent Kinase Inhibitor p21; Cyclopentanes; Female; Gene Expression Regulation; Humans; NEDD8 Protein; Pregnancy; Pyrimidines; RNA, Small Interfering; Trophoblasts; Ubiquitination	2020
Immunomodulatory effects of pevonedistat, a NEDD8-activating enzyme inhibitor, in chronic lymphocytic leukemia-derived T cells. Leukemia, 2021, Volume: 35, Issue:1 Topics: Antineoplastic Agents; Cell Line, Tumor; Cyclopentanes; Enzyme Inhibitors; Humans; Immunomodulation; Leukemia, Prolymphocytic, T-Cell; Lymphocyte Activation; Models, Biological; NEDD8 Protein; Pyrimidines; Receptors, Antigen, T-Cell; Signal Transduction; T-Lymphocytes; T-Lymphocytes, Helper-Inducer	2021
A masked initiation region in retinoblastoma protein regulates its proteasomal degradation. Nature communications, 2020, 04-24, Volume: 11, Issue:1 Topics: Acrylates; Calpain; Cell Cycle; Cell Transformation, Neoplastic; Cyclopentanes; E2F Transcription Factors; Female; Gene Expression Regulation, Neoplastic; HEK293 Cells; Human papillomavirus 16; Humans; NEDD8 Protein; Oligopeptides; Papillomavirus E7 Proteins; Proteasome Endopeptidase Complex; Protein Stability; Pyrimidines; Recombinant Proteins; Retinoblastoma Binding Proteins; Ubiquitin-Protein Ligases; Ubiquitination; Uterine Cervical Neoplasms	2020
Nedd8-activating enzyme inhibitor MLN4924 (Pevonedistat), inhibits miR-1303 to suppress human breast cancer cell proliferation via targeting p27 Experimental cell research, 2020, 07-15, Volume: 392, Issue:2 Topics: Apoptosis; Biomarkers, Tumor; Breast Neoplasms; Cell Cycle; Cell Proliferation; Cyclin-Dependent Kinase Inhibitor p27; Cyclopentanes; Enzyme Inhibitors; Female; Gene Expression Regulation, Neoplastic; Humans; MicroRNAs; NEDD8 Protein; Prognosis; Pyrimidines; Survival Rate; Tumor Cells, Cultured; Ubiquitin-Activating Enzymes	2020
Neddylation inhibition activates the protective autophagy through NF-κB-catalase-ATF3 Axis in human esophageal cancer cells. Cell communication and signaling : CCS, 2020, 05-12, Volume: 18, Issue:1 Topics: Activating Transcription Factor 3; Apoptosis; Autophagy; Catalase; Cell Line, Tumor; Cyclopentanes; Enzyme Inhibitors; Esophageal Neoplasms; Humans; NF-kappa B; Pyrimidines; Signal Transduction; Ubiquitin-Activating Enzymes	2020
UBC12-mediated SREBP-1 neddylation worsens metastatic tumor prognosis. International journal of cancer, 2020, 11-01, Volume: 147, Issue:9 Topics: Animals; Breast; Breast Neoplasms; Carcinoma, Hepatocellular; Cell Line, Tumor; Cyclopentanes; Female; Humans; Liver; Liver Neoplasms; Lymphatic Metastasis; Mice; NEDD8 Protein; Prognosis; Protein Stability; Pyrimidines; Sterol Regulatory Element Binding Protein 1; Survival Rate; Ubiquitin-Activating Enzymes; Ubiquitin-Conjugating Enzymes; Ubiquitination; Up-Regulation; Xenograft Model Antitumor Assays	2020
Suramin and NF449 are IP5K inhibitors that disrupt inositol hexakisphosphate-mediated regulation of cullin-RING ligase and sensitize cancer cells to MLN4924/pevonedistat. The Journal of biological chemistry, 2020, 07-24, Volume: 295, Issue:30 Topics: Benzenesulfonates; Cullin Proteins; Cyclopentanes; Enzyme Inhibitors; HCT116 Cells; HEK293 Cells; Humans; Neoplasm Proteins; Neoplasms; Phosphotransferases (Alcohol Group Acceptor); Phytic Acid; Pyrimidines; Suramin	2020
Reactivation of Epstein-Barr Virus by HIF-1α Requires p53. Journal of virology, 2020, 08-31, Volume: 94, Issue:18 Topics: Cell Line, Tumor; Cyclopentanes; Deferoxamine; Enzyme Inhibitors; Epithelial Cells; Gene Expression Regulation; Glycine; Herpesvirus 4, Human; Host-Pathogen Interactions; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Imidazoles; Iron Chelating Agents; Isoquinolines; Lymphocytes; Morpholines; Piperazines; Prolyl-Hydroxylase Inhibitors; Promoter Regions, Genetic; Protein Binding; Pyrimidines; Pyrones; Response Elements; RNA, Small Interfering; Signal Transduction; Trans-Activators; Tumor Suppressor Protein p53; Virus Activation	2020
The NEDD8-activating enzyme inhibition with MLN4924 sensitizes human cancer cells of different origins to apoptosis and necroptosis. Archives of biochemistry and biophysics, 2020, 09-30, Volume: 691 Topics: Apoptosis; Cell Line, Tumor; Cyclopentanes; Enzyme Inhibitors; Humans; Necroptosis; NF-kappa B; Pyrimidines; Signal Transduction; Tumor Necrosis Factor-alpha; Ubiquitin-Activating Enzymes	2020
NEDDylation negatively regulates ERRβ expression to promote breast cancer tumorigenesis and progression. Cell death & disease, 2020, 08-24, Volume: 11, Issue:8 Topics: Breast Neoplasms; Carcinogenesis; Cell Line, Tumor; Cell Proliferation; Cullin Proteins; Cyclopentanes; Disease Progression; Estrogen Receptor alpha; Estrogen Receptor beta; Female; Gene Expression Regulation, Neoplastic; Humans; NEDD8 Protein; Neoplasm Recurrence, Local; Pyrimidines; Receptors, Estrogen; Ubiquitins	2020
Neddylation inhibitor MLN4924 has anti-HBV activity via modulating the ERK-HNF1α-C/EBPα-HNF4α axis. Journal of cellular and molecular medicine, 2021, Volume: 25, Issue:2 Topics: Animals; Blotting, Southern; Carcinoma, Hepatocellular; Cyclopentanes; Hep G2 Cells; Hepatitis B virus; Hepatocyte Nuclear Factor 4; Humans; Liver Neoplasms; Mice; Pyrimidines; RNA, Messenger; Transcription Factors	2021
The CUL3/neddylation inhibitor MLN4924 reduces ethanol-induced locomotor sensitization and inflammatory pain allodynia in mice. Behavioural brain research, 2021, 02-05, Volume: 399 Topics: Alcoholism; Animals; Central Nervous System Depressants; Central Nervous System Sensitization; Cullin Proteins; Cyclopentanes; Disease Models, Animal; Enzyme Inhibitors; Ethanol; Hyperalgesia; Inflammation; Locomotion; Male; Mice; Mice, Inbred BALB C; NEDD8 Protein; Pyrimidines	2021
The Effect of Neddylation Inhibition on Inflammation-Induced MMP9 Gene Expression in Esophageal Squamous Cell Carcinoma. International journal of molecular sciences, 2021, Feb-09, Volume: 22, Issue:4 Topics: Cell Line, Tumor; Cell Movement; Cyclopentanes; Esophageal Neoplasms; Esophageal Squamous Cell Carcinoma; Gene Expression Regulation, Neoplastic; Humans; Matrix Metalloproteinase 9; NEDD8 Protein; Neoplasm Invasiveness; NF-KappaB Inhibitor alpha; Phosphorylation; Promoter Regions, Genetic; Protein Processing, Post-Translational; Pyrimidines; Transcription Factor RelA; Tumor Necrosis Factor-alpha; Ubiquitin-Activating Enzymes	2021
Neddylation pathway alleviates chronic pancreatitis by reducing HIF1α-CCL5-dependent macrophage infiltration. Cell death & disease, 2021, 03-15, Volume: 12, Issue:3 Topics: Animals; Cell Line; Chemokine CCL5; Chemotaxis; Cyclopentanes; Disease Models, Animal; Enzyme Inhibitors; Female; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Macrophages; Mice, Inbred C57BL; Pancreas; Pancreatitis, Chronic; Phenotype; Pyrimidines; Signal Transduction; Ubiquitin-Activating Enzymes; Ubiquitination	2021
Skp2 and Slug Are Coexpressed in Aggressive Prostate Cancer and Inhibited by Neddylation Blockade. International journal of molecular sciences, 2021, Mar-11, Volume: 22, Issue:6 Topics: Antigens, CD; Antineoplastic Agents; Cadherins; Cell Line, Tumor; Cell Survival; Cyclin-Dependent Kinase Inhibitor p27; Cyclopentanes; Docetaxel; Epithelial-Mesenchymal Transition; Gene Expression Regulation, Neoplastic; Humans; Lymphatic Metastasis; Male; NEDD8 Protein; Neoplasm Grading; PC-3 Cells; Prostate; Prostatic Neoplasms; Protein Processing, Post-Translational; Pyrimidines; Receptors, Androgen; RNA, Small Interfering; S-Phase Kinase-Associated Proteins; Snail Family Transcription Factors	2021
Inhibiting Neddylation with MLN4924 Suppresses Growth and Delays Multicellular Development in Biomolecules, 2021, 03-23, Volume: 11, Issue:3 Topics: Chemotaxis; Cyclopentanes; Dictyostelium; NEDD8 Protein; Protein Processing, Post-Translational; Pyrimidines	2021
Pevonedistat and azacitidine upregulate NOXA (PMAIP1) to increase sensitivity to venetoclax in preclinical models of acute myeloid leukemia. Haematologica, 2022, 04-01, Volume: 107, Issue:4 Topics: Azacitidine; Bridged Bicyclo Compounds, Heterocyclic; Cyclopentanes; Humans; Leukemia, Myeloid, Acute; Pyrimidines; Sulfonamides	2022
Map of ubiquitin-like post-translational modifications in chronic lymphocytic leukemia. Role of p53 lysine 120 NEDDylation. Leukemia, 2021, Volume: 35, Issue:12 Topics: Cells, Cultured; Cyclopentanes; Enzyme Inhibitors; Humans; Leukemia, Lymphocytic, Chronic, B-Cell; Lysine; Mass Spectrometry; NEDD8 Protein; Protein Processing, Post-Translational; Pyrimidines; Tumor Suppressor Protein p53; Ubiquitins	2021
Protein neddylation as a therapeutic target in pulmonary and extrapulmonary small cell carcinomas. Genes & development, 2021, Volume: 35, Issue:11-12 Topics: Animals; Basic Helix-Loop-Helix Transcription Factors; Carcinoma, Small Cell; Cell Death; Cell Line, Tumor; COP9 Signalosome Complex; Cyclopentanes; Disease Models, Animal; Gene Expression Regulation, Neoplastic; Heterografts; Humans; Lung Neoplasms; Mice; NEDD8 Protein; Neuroendocrine Cells; Proteins; Pyrimidines; Repressor Proteins; Sequence Deletion	2021
MLN4924 inhibits cell proliferation by targeting the activated neddylation pathway in endometrial carcinoma. The Journal of international medical research, 2021, Volume: 49, Issue:6 Topics: Apoptosis; Cell Line, Tumor; Cell Proliferation; Cyclopentanes; Endometrial Neoplasms; Female; Humans; NEDD8 Protein; Pyrimidines; Ubiquitins	2021
Dynamics of replication origin over-activation. Nature communications, 2021, 06-08, Volume: 12, Issue:1 Topics: Cell Cycle Proteins; Cell Line, Tumor; Cyclopentanes; DNA Replication; Genome, Human; Humans; Mitosis; Models, Biological; Pyrimidines; Replication Origin	2021
The Anti-Tumor Activity of the NEDD8 Inhibitor Pevonedistat in Neuroblastoma. International journal of molecular sciences, 2021, Jun-18, Volume: 22, Issue:12 Topics: Animals; Antineoplastic Agents; Apoptosis; Cell Cycle; Cell Line, Tumor; Cyclopentanes; Enzyme Inhibitors; Humans; Mice; NEDD8 Protein; Neuroblastoma; Pyrimidines; Tumor Suppressor Protein p53	2021
Inhibition of NAE-dependent protein hyper-NEDDylation in cystic cholangiocytes halts cystogenesis in experimental models of polycystic liver disease. United European gastroenterology journal, 2021, Volume: 9, Issue:7 Topics: Animals; Apoptosis; Bile Ducts; Cell Proliferation; Cell Survival; Cyclopentanes; Cysts; Enzyme Inhibitors; Humans; Liver Diseases; NEDD8 Protein; Protein Processing, Post-Translational; Pyrimidines; Rats; Sumoylation; Ubiquitin-Activating Enzymes; Ubiquitin-Conjugating Enzymes; Up-Regulation	2021
MLN4924 inhibits hedgehog signaling pathway and activates autophagy to alleviate mouse laser-induced choroidal neovascularization lesion. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2020, Volume: 130 Topics: Animals; Autophagy; Biomarkers; Choroidal Neovascularization; Cyclopentanes; Disease Management; Disease Models, Animal; Disease Susceptibility; Endothelial Cells; Hedgehog Proteins; Lasers; Mice; Pyrimidines; Retinal Pigment Epithelium; Signal Transduction	2020
Organoid-based drug screening reveals neddylation as therapeutic target for malignant rhabdoid tumors. Cell reports, 2021, 08-24, Volume: 36, Issue:8 Topics: Animals; Cell Line, Tumor; Cyclopentanes; Female; Gene Expression Regulation, Neoplastic; Humans; Male; Mice; Mice, Inbred NOD; Mice, SCID; Organoids; Pyrimidines; Rhabdoid Tumor; Unfolded Protein Response; Xenograft Model Antitumor Assays	2021
Nedd8-Activating Enzyme Is a Druggable Host Dependency Factor of Human and Mouse Cytomegalovirus. Viruses, 2021, 08-14, Volume: 13, Issue:8 Topics: Animals; Antiviral Agents; Cell Line; Cell Line, Tumor; Cullin Proteins; Cyclopentanes; Cytomegalovirus; Host Microbial Interactions; Humans; Mice; Muromegalovirus; NEDD8 Protein; Protein Processing, Post-Translational; Proteome; Pyrimidines; Pyrroles; Ubiquitin-Activating Enzymes; Ubiquitin-Protein Ligases	2021
Quantitative analyses for effects of neddylation on CRL2 Protein science : a publication of the Protein Society, 2021, Volume: 30, Issue:11 Topics: Cullin Proteins; Cyclopentanes; HEK293 Cells; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; NEDD8 Protein; Proteolysis; Pyrimidines; Ubiquitination; Von Hippel-Lindau Tumor Suppressor Protein	2021
Pevonedistat attenuates cisplatin-induced nephrotoxicity in mice by downregulating the release of inflammatory mediators. Journal of biochemical and molecular toxicology, 2021, Volume: 35, Issue:11 Topics: Animals; Antineoplastic Agents; Cisplatin; Cyclopentanes; Down-Regulation; Enzyme Inhibitors; Enzyme-Linked Immunosorbent Assay; Inflammation Mediators; Kidney; Male; Mice; Pyrimidines	2021
Immunomodulatory effect of NEDD8-activating enzyme inhibition in Multiple Myeloma: upregulation of NKG2D ligands and sensitization to Natural Killer cell recognition. Cell death & disease, 2021, 09-04, Volume: 12, Issue:9 Topics: Aged; Aged, 80 and over; Cell Degranulation; Cell Line, Tumor; Cyclopentanes; Female; Gene Expression Regulation, Neoplastic; Histocompatibility Antigens Class I; Humans; Immunologic Factors; Immunomodulation; Intracellular Signaling Peptides and Proteins; Killer Cells, Natural; Ligands; Male; Middle Aged; Multiple Myeloma; NEDD8 Protein; NK Cell Lectin-Like Receptor Subfamily K; Plasma Cells; Promoter Regions, Genetic; Pyrimidines; Up-Regulation	2021
Pevonedistat targets malignant cells in myeloproliferative neoplasms in vitro and in vivo via NFκB pathway inhibition. Blood advances, 2022, 01-25, Volume: 6, Issue:2 Topics: Animals; Cyclopentanes; Humans; Leukemia, Myeloid, Acute; Mice; Myeloproliferative Disorders; Primary Myelofibrosis; Pyrimidines	2022
Blocking neddylation elicits antiviral effect against hepatitis B virus replication. Molecular biology reports, 2022, Volume: 49, Issue:1 Topics: Antiviral Agents; Cell Survival; Cyclopentanes; DNA, Viral; Gene Expression Regulation; Hep G2 Cells; Hepatitis B e Antigens; Hepatitis B Surface Antigens; Hepatitis B virus; Humans; NEDD8 Protein; Pyrimidines; RNA, Small Interfering; Virus Replication	2022
Integrated RNAi screening identifies the NEDDylation pathway as a synergistic partner of azacytidine in acute myeloid leukemia. Scientific reports, 2021, 12-02, Volume: 11, Issue:1 Topics: Azacitidine; Chemokine CXCL12; Combined Modality Therapy; Cyclopentanes; HL-60 Cells; Humans; Leukemia, Myeloid, Acute; NEDD8 Protein; Pre-B-Cell Leukemia Transcription Factor 1; Pyrimidines; RNA Interference; Signal Transduction	2021
Gene expression profiling reveals the genomic changes caused by MLN4924 and the sensitizing effects of NAPEPLD knockdown in pancreatic cancer. Cell cycle (Georgetown, Tex.), 2022, Volume: 21, Issue:2 Topics: Animals; Apoptosis; Cell Line, Tumor; Cyclopentanes; Gene Expression Profiling; Mice; Pancreatic Neoplasms; Pyrimidines	2022
The NEDD8-activating enzyme inhibitor MLN4924 reduces ischemic brain injury in mice. Proceedings of the National Academy of Sciences of the United States of America, 2022, 02-08, Volume: 119, Issue:6 Topics: Animals; Brain Injuries; Brain Ischemia; Cyclopentanes; Male; Mice; NEDD8 Protein; Nerve Tissue Proteins; Protein Processing, Post-Translational; Pyrimidines; Ubiquitin-Protein Ligases	2022
Cullin neddylation inhibitor attenuates hyperglycemia by enhancing hepatic insulin signaling through insulin receptor substrate stabilization. Proceedings of the National Academy of Sciences of the United States of America, 2022, 02-08, Volume: 119, Issue:6 Topics: Animals; Cell Line; Cullin Proteins; Cyclopentanes; Hyperglycemia; Insulin; Liver; Male; Mice; Mice, Inbred C57BL; NEDD8 Protein; Pyrimidines; Receptor, Insulin; Signal Transduction; Ubiquitin-Protein Ligases; Ubiquitination; Ubiquitins	2022
PTEN loss drives resistance to the neddylation inhibitor MLN4924 in glioblastoma and can be overcome with TOP2A inhibitors. Neuro-oncology, 2022, 11-02, Volume: 24, Issue:11 Topics: Apoptosis; Cell Line, Tumor; Cyclopentanes; Drug Resistance, Neoplasm; Glioblastoma; Humans; NEDD8 Protein; PTEN Phosphohydrolase; Pyrimidines; Topoisomerase II Inhibitors	2022
MLN4924 Inhibits Defective Ribosomal Product Antigen Presentation Independently of Direct NEDDylation of Protein Antigens. Journal of immunology (Baltimore, Md. : 1950), 2022, 05-15, Volume: 208, Issue:10 Topics: Animals; Antigen Presentation; CD8-Positive T-Lymphocytes; Cyclopentanes; Mice; NEDD8 Protein; Proteasome Endopeptidase Complex; Proteins; Pyrimidines; Ubiquitin; Ubiquitins	2022
Targeting neddylation in cancer. Neuro-oncology, 2022, 11-02, Volume: 24, Issue:11 Topics: Cyclopentanes; Glioblastoma; Humans; PTEN Phosphohydrolase; Pyrimidines	2022
Activation of the β‑TrCP/IκBα/inflammation axis limits the sensitivity of liver cancer cells to neddylation inhibition. Oncology reports, 2022, Volume: 48, Issue:5 Topics: Apoptosis; beta-Transducin Repeat-Containing Proteins; Cell Line, Tumor; Cycloheximide; Cyclopentanes; Humans; Inflammation; Liver Neoplasms; NF-KappaB Inhibitor alpha; Pyrimidines; RNA, Messenger; Ubiquitin-Activating Enzymes; Ubiquitins; Xenograft Model Antitumor Assays	2022
PD-L1 induction via the MEK-JNK-AP1 axis by a neddylation inhibitor promotes cancer-associated immunosuppression. Cell death & disease, 2022, 10-03, Volume: 13, Issue:10 Topics: Animals; Apoptosis; Cell Line, Tumor; Cyclopentanes; Humans; Immunosuppression Therapy; Mice; Mitogen-Activated Protein Kinase Kinases; NEDD8 Protein; Neoplasms; Protein Kinase Inhibitors; Pyrimidines; RNA, Messenger; Transcription Factor AP-1	2022
Neddylation-mediated degradation of hnRNPA2B1 contributes to hypertriglyceridemia pancreatitis. Cell death & disease, 2022, 10-11, Volume: 13, Issue:10 Topics: Acute Disease; Animals; Cyclopentanes; Heterogeneous-Nuclear Ribonucleoprotein Group A-B; Hypertriglyceridemia; Mice; Mitochondrial Trifunctional Protein; NF-kappa B; Palmitic Acid; Pancreatitis; Pyrimidines; RNA	2022
A small molecule inhibitor of the UBE2F-CRL5 axis induces apoptosis and radiosensitization in lung cancer. Signal transduction and targeted therapy, 2022, 10-17, Volume: 7, Issue:1 Topics: Apoptosis; Cell Line, Tumor; Cullin Proteins; Cyclopentanes; DNA Adducts; G2 Phase Cell Cycle Checkpoints; Humans; Lung Neoplasms; Pyrimidines; Ubiquitin-Conjugating Enzymes; Ubiquitin-Protein Ligases	2022
Pharmacologic targeting of Nedd8-activating enzyme reinvigorates T-cell responses in lymphoid neoplasia. Leukemia, 2023, Volume: 37, Issue:6 Topics: Antineoplastic Agents; CD8-Positive T-Lymphocytes; Cell Line, Tumor; Cyclopentanes; Humans; Lymphoma; NEDD8 Protein; Tumor Microenvironment; Ubiquitin-Conjugating Enzymes	2023
Schlafen 11 (SLFN11) Kills Cancer Cells Undergoing Unscheduled Re-replication. Molecular cancer therapeutics, 2023, 08-01, Volume: 22, Issue:8 Topics: Antineoplastic Agents; Cell Line, Tumor; Chromatin; Cyclopentanes; Humans; Neoplasms; Nuclear Proteins	2023
Deneddylation of ribosomal proteins promotes synergy between MLN4924 and chemotherapy to elicit complete therapeutic responses. Cell reports, 2023, 08-29, Volume: 42, Issue:8 Topics: Apoptosis; bcl-2-Associated X Protein; Cell Line, Tumor; Cyclopentanes; NEDD8 Protein; Ribosomal Proteins; Topotecan; Tumor Suppressor Protein p53	2023
Oncolytic virus and inhibitor for NEDD8-activating enzyme pevonedistat: Promising combination for cancer therapy? Molecular therapy : the journal of the American Society of Gene Therapy, 2023, 11-01, Volume: 31, Issue:11 Topics: Antineoplastic Agents; Cyclopentanes; Enzyme Inhibitors; Humans; NEDD8 Protein; Neoplasms; Oncolytic Viruses	2023