cyclopentane has been researched along with neramexane in 31 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 5 (16.13) | 18.2507 |
| 2000's | 25 (80.65) | 29.6817 |
| 2010's | 1 (3.23) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Baker, LM; Danysz, W; Hauss-Wegrzyniak, B; Stoehr, JD; Wenk, GL | 1 |
| Danysz, W; Karcz-Kubicha, M; Lorenz, B | 1 |
| Belozertseva, IV; Bespalov, AY; Dravolina, OA; Sukhotina, IA | 1 |
| Bespalov, A; Danysz, W; Semenova, S | 1 |
| Danysz, W; Hesselink, MB; Parsons, CG; Wollenburg, C | 1 |
| Danysz, W; Hölter, SM; Spanagel, R | 1 |
| Danysz, W; Frankiewicz, T; Parsons, C; Sopala, M | 1 |
| Danysz, W; Kozela, E; Popik, P | 1 |
| Belayev, L; Busto, R; Ginsberg, MD; Liu, Y; Zhao, W | 1 |
| Bespalov, AY; Sukhotina, IA | 1 |
| Danysz, W; Parsons, CG; Quack, G | 1 |
| Bienkowski, P; Danysz, W; Koros, E; Kostowski, W; Krzascik, P; Scinska, A | 1 |
| Headley, MP; Houghton, AK; Parsons, CG | 1 |
| Ferrari, U; Parsons, CG; Rammes, G; Rupprecht, R; Zieglgänsberger, W | 1 |
| Davies, JA; Marsh, WL; Naish, HJ | 1 |
| Escobar, MR; Fourie, J; Sitar, DS | 1 |
| Bespalov, AY; Danysz, W; Sukhotina, IA; Zvartau, EE | 1 |
| Biala, G; Bochenski, M; Danysz, W; Kotlinska, J; Rafalski, P | 1 |
| Bachteler, D; Ciccocioppo, R; Danysz, W; Economidou, D; Spanagel, R | 1 |
| Bespalov, AY; Danysz, W; Malyshkin, AA; Medvedev, IO | 1 |
| Bochenski, M; Danysz, W; Kotlinska, J | 1 |
| Rammes, G; Schierloh, A | 1 |
| Danysz, W; Kos, T; Legutko, B; Popik, P; Samoriski, G | 1 |
| Campbell, AM; Danysz, W; Diamond, DM; Park, CR; Schaefer, D; Zoladz, PR | 1 |
| Althaus, M; Hanschmann, A; Klein, T; Magerl, W; Treede, RD | 1 |
| Elgoyhen, AB; Gomez-Casati, ME; Katz, E; Kracun, S; Millar, NS; Parsons, CG; Plazas, PV; Savino, J | 1 |
| Gilling, K; Jatzke, C; Jirgensons, A; Kauss, V; Parsons, CG; Vanejevs, M; Wollenburg, C | 1 |
| Chen, SR; Pan, HL; Samoriski, G | 1 |
| Alam, M; Danysz, W; Dekundy, A; Schmidt, WJ | 1 |
| Ahmad, SU; Kumar, J; Mohamed, IN; Pakri Mohamed, RM | 1 |
4 review(s) available for cyclopentane and neramexane
| Article | Year |
|---|---|
Memantine and the amino-alkyl-cyclohexane MRZ 2/579 are moderate affinity uncompetitive NMDA receptor antagonists--in vitro characterisation.
Topics: Animals; Cyclopentanes; Excitatory Amino Acid Antagonists; In Vitro Techniques; Memantine; Rats; Receptors, N-Methyl-D-Aspartate | 2000 |
Neramexane.
Topics: Alcoholism; Animals; Cyclopentanes; Humans; Neuroprotective Agents; Pain; Receptors, N-Methyl-D-Aspartate | 2002 |
Neramexane (merz pharmaceuticals/forest laboratories).
Topics: Animals; Clinical Trials as Topic; Cyclopentanes; Humans; Nervous System Diseases; Neuroprotective Agents; Receptors, N-Methyl-D-Aspartate; Treatment Outcome | 2006 |
Novel Pharmacotherapeutic Approaches in Treatment of Alcohol Addiction.
Topics: Alcohol Deterrents; Alcoholism; Animals; Aripiprazole; Baclofen; Cyclopentanes; Gabapentin; Humans; Naltrexone; Quetiapine Fumarate | 2018 |
1 trial(s) available for cyclopentane and neramexane
| Article | Year |
|---|---|
Antihyperalgesic and analgesic properties of the N-methyl-D-aspartate (NMDA) receptor antagonist neramexane in a human surrogate model of neurogenic hyperalgesia.
Topics: Aminopyridines; Analgesics; Capsaicin; Cross-Over Studies; Cyclopentanes; Dose-Response Relationship, Drug; Double-Blind Method; Humans; Hyperalgesia; Injections, Intradermal; Nervous System Diseases; Pain; Physical Stimulation; Receptors, N-Methyl-D-Aspartate; Treatment Outcome | 2008 |
26 other study(ies) available for cyclopentane and neramexane
| Article | Year |
|---|---|
Neuroprotection by novel antagonists at the NMDA receptor channel and glycineB sites.
Topics: Acetylcholine; Animals; Cyclopentanes; Enzyme Inhibitors; Male; Mitochondria; Neuroprotective Agents; Neurotoxins; Nitro Compounds; Propionates; Rats; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate; Substantia Innominata; Succinate Dehydrogenase | 1998 |
GlycineB antagonists and partial agonists in rodent models of Parkinson's disease--comparison with uncompetitive N-methyl-D-aspartate receptor antagonist.
Topics: Animals; Antiparkinson Agents; Binding, Competitive; Catalepsy; Cyclopentanes; Drug Evaluation, Preclinical; Drug Synergism; Excitatory Amino Acid Antagonists; Glycine Agents; Haloperidol; Hypnotics and Sedatives; Levodopa; Male; Neuroprotective Agents; Parkinson Disease, Secondary; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Reserpine | 1999 |
Morphine tolerance and dependence in mice with history of repeated exposures to NMDA receptor channel blockers.
Topics: Analgesics, Opioid; Animals; Cyclopentanes; Dizocilpine Maleate; Drug Tolerance; Excitatory Amino Acid Antagonists; Interpersonal Relations; Male; Memantine; Mice; Morphine; Morphine Dependence; Reaction Time; Receptors, N-Methyl-D-Aspartate | 1999 |
Low-affinity NMDA receptor channel blockers inhibit acquisition of intravenous morphine self-administration in naive mice.
Topics: Analysis of Variance; Animals; Cyclopentanes; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Injections, Intravenous; Male; Memantine; Mice; Mice, Inbred DBA; Morphine; Narcotics; Neuroprotective Agents; Receptors, N-Methyl-D-Aspartate; Self Administration | 1999 |
Brain distribution of an uncompetitive NMDA receptor antagonist; comparison to its in vitro potency in electrophysiological studies.
Topics: Animals; Binding, Competitive; Calcium Channels; Cyclopentanes; Dose-Response Relationship, Drug; Hippocampus; In Vitro Techniques; Microdialysis; Neuroprotective Agents; Patch-Clamp Techniques; Rats; Receptors, GABA-A; Receptors, N-Methyl-D-Aspartate; Receptors, Nicotinic; Time Factors | 1999 |
Novel uncompetitive N-methyl-D-aspartate (NMDA)-receptor antagonist MRZ 2/579 suppresses ethanol intake in long-term ethanol-experienced rats and generalizes to ethanol cue in drug discrimination procedure.
Topics: Alcohol Drinking; Animals; Cyclopentanes; Discrimination Learning; Dose-Response Relationship, Drug; Drinking; Male; Neuroprotective Agents; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Self Administration; Substance Withdrawal Syndrome; Time Factors | 2000 |
Middle cerebral artery occlusion produces secondary, remote impairment in hippocampal plasticity of rats - involvement of N-methyl-D-aspartate receptors?
Topics: Animals; Arterial Occlusive Diseases; Cerebral Arterial Diseases; Cyclopentanes; Excitatory Postsynaptic Potentials; Hippocampus; Ischemic Attack, Transient; Long-Term Potentiation; Male; Middle Cerebral Artery; Neuronal Plasticity; Neuroprotective Agents; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate | 2000 |
Clinically available NMDA receptor antagonists memantine and dextromethorphan reverse existing tolerance to the antinociceptive effects of morphine in mice.
Topics: Analgesics, Opioid; Animals; Cyclopentanes; Dextromethorphan; Drug Tolerance; Excitatory Amino Acid Antagonists; Male; Memantine; Mice; Morphine; Receptors, N-Methyl-D-Aspartate; Tail | 2000 |
MRZ 2/579, a novel uncompetitive N-methyl-D-aspartate antagonist, reduces infarct volume and brain swelling and improves neurological deficit after focal cerebral ischemia in rats.
Topics: Animals; Brain Edema; Brain Ischemia; Cerebral Cortex; Cyclopentanes; Excitatory Amino Acid Agonists; Image Processing, Computer-Assisted; Infarction, Middle Cerebral Artery; Male; N-Methylaspartate; Neostriatum; Neurologic Examination; Neuroprotective Agents; Rats; Rats, Sprague-Dawley | 2000 |
Effects of the NMDA receptor channel blockers memantine and MRZ 2/579 on morphine withdrawal-facilitated aggression in mice.
Topics: Aggression; Animals; Cyclopentanes; Excitatory Amino Acid Antagonists; Male; Memantine; Mice; Morphine; Narcotics; Receptors, N-Methyl-D-Aspartate; Social Behavior; Substance Withdrawal Syndrome | 2000 |
Effects of a novel uncompetitive NMDA receptor antagonist, MRZ 2/579 on ethanol self-administration and ethanol withdrawal seizures in the rat.
Topics: Alcohol Drinking; Alcohol Withdrawal Seizures; Animals; Conditioning, Operant; Cyclopentanes; Diazepam; Epilepsy, Reflex; Ethanol; Male; Memantine; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Self Administration; Sleep | 2001 |
Mrz 2/579, a fast kinetic NMDA channel blocker, reduces the development of morphine tolerance in awake rats.
Topics: Analgesics, Opioid; Animals; Cyclopentanes; Drug Tolerance; Male; Morphine; Neuroprotective Agents; Pain; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Sodium Chloride; Substance Withdrawal Syndrome; Wakefulness | 2001 |
The N-methyl-D-aspartate receptor channel blockers memantine, MRZ 2/579 and other amino-alkyl-cyclohexanes antagonise 5-HT(3) receptor currents in cultured HEK-293 and N1E-115 cell systems in a non-competitive manner.
Topics: Animals; Antidepressive Agents; Binding, Competitive; Cell Membrane; Cells, Cultured; Cyclohexanes; Cyclopentanes; Depression; Dose-Response Relationship, Drug; Drug Interactions; Excitatory Amino Acid Antagonists; Humans; Memantine; Membrane Potentials; Mice; Neuroprotective Agents; Receptors, N-Methyl-D-Aspartate; Receptors, Serotonin; Receptors, Serotonin, 5-HT3; Serotonin Antagonists | 2001 |
Effect of low-affinity NMDA receptor antagonists on electrical activity in mouse cortical slices.
Topics: Animals; Cerebral Cortex; Cyclopentanes; Dextromethorphan; Electric Conductivity; Electrophysiology; Epilepsy; Excitatory Amino Acid Antagonists; Female; In Vitro Techniques; Male; Mice; Mice, Inbred DBA; Pyridines; Receptors, N-Methyl-D-Aspartate | 2002 |
NMDA receptor antagonists to characterize rat renal organic cation transporter function.
Topics: Amantadine; Animals; Cyclopentanes; Drug Interactions; Energy Metabolism; Excitatory Amino Acid Antagonists; In Vitro Techniques; Kidney; Kidney Tubules; Kinetics; Male; Memantine; Organic Cation Transport Proteins; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Structure-Activity Relationship | 2002 |
Caffeine withdrawal syndrome in social interaction test in mice: effects of the NMDA receptor channel blockers, memantine and neramexane.
Topics: Animals; Caffeine; Cyclopentanes; Dose-Response Relationship, Drug; Injections, Intraperitoneal; Male; Memantine; Mice; Motor Activity; Receptors, N-Methyl-D-Aspartate; Social Behavior; Substance Withdrawal Syndrome; Time Factors | 2004 |
Effect of neramexane on ethanol dependence and reinforcement.
Topics: Acamprosate; Alcohol Deterrents; Alcoholism; Animals; Behavior, Animal; Central Nervous System Depressants; Conditioning, Operant; Cyclopentanes; Ethanol; Male; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Reinforcement, Psychology; Seizures; Substance Withdrawal Syndrome; Taurine | 2004 |
The effects of acamprosate and neramexane on cue-induced reinstatement of ethanol-seeking behavior in rat.
Topics: Acamprosate; Alcohol Deterrents; Alcohol Drinking; Animals; Conditioning, Operant; Cues; Cyclopentanes; Extinction, Psychological; Injections, Intraperitoneal; Male; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Recurrence; Taurine | 2005 |
Anti-allodynic interactions between NMDA receptor channel blockers and morphine or clonidine in neuropathic rats.
Topics: Adrenergic alpha-2 Receptor Agonists; Analgesics; Analgesics, Opioid; Animals; Clonidine; Cyclopentanes; Dose-Response Relationship, Drug; Drug Interactions; Male; Memantine; Morphine; Pain Measurement; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Receptors, Opioid, mu; Sciatic Neuropathy | 2005 |
N-methyl-D-aspartate and group I metabotropic glutamate receptors are involved in the expression of ethanol-induced sensitization in mice.
Topics: Acamprosate; Alcoholism; Animals; Brain; Cyclopentanes; Dizocilpine Maleate; Dose-Response Relationship, Drug; Drug Synergism; Ethanol; Glutamic Acid; Male; Mice; Motor Activity; N-Methylaspartate; Pyridines; Quinolines; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate; Stereotyped Behavior; Synaptic Transmission; Taurine; Thiazoles | 2006 |
Enhancement of antidepressant-like effects but not brain-derived neurotrophic factor mRNA expression by the novel N-methyl-D-aspartate receptor antagonist neramexane in mice.
Topics: Animals; Antidepressive Agents; Brain-Derived Neurotrophic Factor; Cyclopentanes; Excitatory Amino Acid Antagonists; Male; Mice; Mice, Inbred C57BL; Receptors, N-Methyl-D-Aspartate; RNA, Messenger | 2006 |
Enhancement of long-term spatial memory in adult rats by the noncompetitive NMDA receptor antagonists, memantine and neramexane.
Topics: Alzheimer Disease; Animals; Brain-Derived Neurotrophic Factor; Cyclopentanes; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Long-Term Potentiation; Male; Maze Learning; Memantine; Memory; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate | 2006 |
Inhibition of the alpha9alpha10 nicotinic cholinergic receptor by neramexane, an open channel blocker of N-methyl-D-aspartate receptors.
Topics: Acetylcholine; Animals; Cell Line; Cyclopentanes; Hair Cells, Auditory, Inner; Humans; Memantine; Nicotinic Antagonists; Oocytes; Protein Subunits; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Receptors, Nicotinic; Recombinant Proteins; Xenopus laevis | 2007 |
A novel class of amino-alkylcyclohexanes as uncompetitive, fast, voltage-dependent, N-methyl-D-aspartate (NMDA) receptor antagonists--in vitro characterization.
Topics: Animals; Aza Compounds; Azabicyclo Compounds; Binding, Competitive; Cells, Cultured; Cyclohexylamines; Cyclopentanes; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Hippocampus; In Vitro Techniques; Inhibitory Concentration 50; Memantine; Membrane Potentials; Neurons; Patch-Clamp Techniques; Rats; Receptors, N-Methyl-D-Aspartate; Spiro Compounds | 2007 |
Antinociceptive effects of chronic administration of uncompetitive NMDA receptor antagonists in a rat model of diabetic neuropathic pain.
Topics: Amines; Analgesics; Animals; Cyclohexanecarboxylic Acids; Cyclopentanes; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Disease Models, Animal; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Gabapentin; gamma-Aminobutyric Acid; Male; Memantine; Pain; Pain Measurement; Physical Stimulation; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Streptozocin; Time Factors | 2009 |
Effects of glutamate and alpha2-noradrenergic receptor antagonists on the development of neurotoxicity produced by chronic rotenone in rats.
Topics: Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Antagonists; Animals; Basal Ganglia; Behavior, Animal; Catalepsy; Cyclopentanes; Disease Models, Animal; Dopamine; Excitatory Amino Acid Antagonists; Hypokinesia; Idazoxan; Male; Motor Activity; Muscle Rigidity; Neuroprotective Agents; Neurotoxicity Syndromes; Parkinsonian Disorders; Pyridines; Rats; Rats, Sprague-Dawley; Receptor, Metabotropic Glutamate 5; Receptors, Adrenergic, alpha-2; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate; Rotenone; Serotonin; Substantia Nigra; Time Factors | 2009 |