cyclopentane has been researched along with brefeldin a in 848 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 23 (2.71) | 18.7374 |
| 1990's | 824 (97.17) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (0.12) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Aosai, F; Baba, T; Norose, K; Ohno, S; Segawa, K; Yamashita, K; Yano, A | 1 |
| Gapud, CP; Keil, W; Reiss, CS | 1 |
| Bennink, J; Esquivel, F; Yewdell, J | 1 |
| Kirkegaard, K; Klymkowsky, MW; Maynell, LA | 1 |
| Black, N; Brown, KS; Firestone, GL; Kain, SR; Platt, EJ | 1 |
| Becker, D; Knop, J; Neis, S; Neiss, U; Reske, K | 1 |
| Hsu, VW; Klausner, RD; Shah, N | 1 |
| Braulke, T; Damke, H; Klumperman, J; von Figura, K | 2 |
| Agricola, B; Bogner, E; Eggers, M; Kern, HF; Radsak, K | 1 |
| Carrasco, L; Irurzun, A; Perez, L | 3 |
| Chatterjee, S; Sarkar, S | 1 |
| McCormick, S; Nauseef, WM; Yi, H | 1 |
| Allavena, G; Bajetto, A; Rubartelli, A; Sitia, R; Wollman, E | 1 |
| Hong, W; Low, SH; Tang, BL; Wong, SH | 2 |
| Borchelt, DR; Prusiner, SB; Raeber, AJ; Serban, D; Taraboulos, A | 1 |
| McGuinness, MP; Orth, JM | 1 |
| Polakova, K; Russ, G | 1 |
| Corsetti, JP; Sparks, CE; Sparks, JD; Way, BA | 1 |
| Carlin, C; Hoffman, BL; Hoffman, P; Wold, WS; Yaffe, MB; Yei, S | 1 |
| Palade, GE; Schnitzer, JE; Ulmer, JB | 1 |
| Chakrabarti, D; Ghosh, SK | 1 |
| Higashiura, M; Yagura, T; Yamauchi, T | 1 |
| Erlich, R; Gleeson, PA; Kooy, J; Pettitt, JM; Toh, BH | 1 |
| Amitay, R; Bar-Nun, S; Haimovich, J; Rabinovich, E; Shachar, I | 2 |
| Chen, CH; Sugai, M; Wu, HC | 2 |
| Hansen, SH; Prydz, K; Sandvig, K; van Deurs, B | 2 |
| Brown, WJ; Wood, SA | 1 |
| Hurtley, SM | 1 |
| Morris, JF; Pow, DV | 1 |
| Black, VH; De Lemos-Chiarandini, C; Gumper, I; Ivessa, NE; Kreibich, G; Tsao, YS | 1 |
| Farquhar, MG; Hendricks, LC; McCaffery, M; McClanahan, SL; Palade, GE | 1 |
| Garcia-Navarro, R; Gracia-Navarro, F; Hidalgo, J; Perez-Vilar, J; Velasco, A | 1 |
| Hollinshead, M; Tooze, J | 2 |
| Gressner, AM; Gressner, G; Lahme, B; Lotfi, S | 1 |
| Dixon, JL; Furukawa, S; Ginsberg, HN; Sakata, N | 1 |
| Bernstein, HB; Compans, RW | 1 |
| Maldarelli, F; Martin, MA; Strebel, K; Willey, RL | 1 |
| Adamcová, J; Fuska, J; Proksa, B; Uhrin, D | 1 |
| Fransson, LA; Karlsson, P; Schmidtchen, A | 1 |
| Bähler, P; Lottaz, D; Oberholzer, T; Semenza, G; Sterchi, EE | 1 |
| Donaldson, JG; Finazzi, D; Klausner, RD | 1 |
| Helms, JB; Rothman, JE | 1 |
| Moskalewski, S; Thyberg, J | 1 |
| Kikuchi, M; Omura, F; Otsu, M; Tashiro, Y; Yoshimori, T | 1 |
| Chen, CH; Kuwazuru, Y; Nambiar, M; Wu, HC; Yoshida, T | 1 |
| Bonatti, S; Erra, MC; Leone, A; Malagolini, N; Pascale, MC; Serafini-Cessi, F | 1 |
| Holmes, EH; Sherwood, AL | 1 |
| Hong, W; Qi, X; Subramaniam, VN; Tang, BL; Wong, SH | 1 |
| Howell, KE; Ladinsky, MS | 1 |
| Curran, PK; Fishman, PH | 1 |
| Allan, D; Kallen, KJ; Quinn, P | 3 |
| Eskelinen, S; Hoekstra, D; Hoekstra, K; Kok, JW | 1 |
| Barr, FA; Binacchi, C; Huttner, WB; Rosa, P; Stinchcombe, JC | 1 |
| Farquhar, MG; Hendricks, LC; McClanahan, SL; Palade, GE | 1 |
| Holwerda, BC; Padgett, HS; Rogers, JC | 1 |
| Crary, JL; Haldar, K | 1 |
| Betina, V | 1 |
| Calderwood, SK; Mannheim-Rodman, LA; Price, BD | 1 |
| Nasciutti, LE; Picart, R; Rosenbaum, E; Tixier-Vidal, A; Tougard, C | 1 |
| Dishon, DS; Ferrell, GA; Le, A; Le, QQ; Sifers, RN | 1 |
| Grässel, S; Hasilik, A | 1 |
| Inoue, S; Simoni, RD | 1 |
| Freeze, HH; Sampath, D; Varki, A | 2 |
| Bolscher, J; Feltkamp, C; Ploegh, H; Tan, A | 1 |
| Brüning, A; Karrenbauer, A; Schnabel, E; Wieland, FT | 1 |
| Ktistakis, NT; Linder, ME; Roth, MG | 1 |
| Buxbaum, JD; Caporaso, GL; Gandy, SE; Greengard, P | 1 |
| Katsman, M; Silbert, JE; Sugumaran, G | 2 |
| Lee, AS; Liu, ES; Ou, JH | 1 |
| Kreis, TE; Robinson, MS | 1 |
| Ben-Zeev, O; Davis, RC; Doolittle, MH; Elovson, J; Schotz, MC | 1 |
| Burke, B; Doherty, J; Matlin, KS; McMorrow, I; Narula, N; Plopper, G; Stow, JL | 1 |
| Brüning, A; Ishikawa, T; Kneusel, RE; Lottspeich, F; Matern, U; Wieland, FT | 1 |
| Ben-Naim, M; Dabach, Y; Hollander, G; Stein, O; Stein, Y | 2 |
| Draper, RK; Kao, CY | 1 |
| Adesnik, M; De Lemos-Chiarandini, C; Ivessa, NE; Kreibich, G; Sabatini, DD; Takatsuki, A; Tsao, YS | 1 |
| Bushkin, Y; Demaria, S; Schwab, R | 1 |
| Bouwer, HG; Gibbins, BL; Hinrichs, DJ; Nelson, CS; Portnoy, DA | 1 |
| Fujiwara, T; Goto, Y; Ikehara, Y; Kung, HF; Kuwano, M; Nishioka, M; Ono, M; Seguchi, T; Shimada, T | 1 |
| Huttner, WB; Mantovani, S; Rosa, P; Rosboch, R | 1 |
| Brodsky, FM; Wong, DH | 1 |
| Hatch, GM; Vance, DE | 1 |
| Shah, D; Shen, WC; Taub, ME; Wan, J | 1 |
| Bangs, JD; Elmendorf, HG; Haldar, K | 1 |
| Kahn, RA; Melançon, P; Taylor, TC | 1 |
| Glick, JM; Harrison, EH; Marsh, JB; Ross, AC; Winkler, KE | 1 |
| Griffiths, G; Horzinek, MC; Locker, JK; Rottier, PJ | 1 |
| Carnell, L; Miller, SG; Moore, HH | 1 |
| Hannun, YA; Jayadev, S; Linardic, CM | 2 |
| Collins, PL; Mottet, G | 2 |
| Hunziker, W; Mellman, I; Whitney, JA | 2 |
| Heldin, CH; Ostman, A; Thyberg, J; Westermark, B | 1 |
| Brown, WJ; Park, JE; Wood, SA | 1 |
| Pelham, HR | 2 |
| Bächi, T; Bennink, JR; Russ, G; Yewdell, JW | 1 |
| Bennink, JR; Hackett, CJ; Wysocka, M; Yewdell, JW | 1 |
| Kaye, PM; Lang, T | 1 |
| Amherdt, M; Klausner, RD; Lippincott-Schwartz, J; Orci, L; Tipper, C; Yuan, L | 1 |
| Balch, WE; de Silva, AM; Helenius, A | 1 |
| Bloom, GS; Ktistakis, NT; Roth, MG | 1 |
| Fisher, RS; Grillo, FG; Zizi, M | 1 |
| Hoke, GM; Mumbauer, S; Pal, R; Sarngadharan, MG; Takatsuki, A | 1 |
| Mundy, DI; Warren, G | 1 |
| Alcalde, J; Bonay, P; Roa, A; Sandoval, IV; Vilaro, S | 1 |
| Banting, G; Reaves, B | 2 |
| Brown, MS; Dawson, PA; Goldstein, JL; Ho, YK; Ridgway, ND | 1 |
| Bertoletti, A; Cavalli, A; Chisari, FV; Fiaccadori, F; Fowler, P; Guilhot, S; Margolskee, RF; Moss, B; Penna, A; Valli, A | 1 |
| Donaldson, JG; Klausner, RD; Lippincott-Schwartz, J | 2 |
| Ikehara, Y; Ikemizu, J; Misumi, Y; Murakami, K; Nagahama, M; Nakayama, K | 1 |
| Bird, MM; Carroll, M | 1 |
| Burgess, TL; Skoufias, DA; Wilson, L | 1 |
| Hunziker, W; Mellman, I | 1 |
| Johnson, MJ; Magner, JA; Miura, Y; Rubin, D | 1 |
| Carson, GR; Kane, LP; Terhorst, C; Wileman, T | 1 |
| Goings, GE; Hanck, DA; Page, E; Upshaw-Earley, J | 1 |
| Donaldson, JG; Glickman, J; Klausner, RD; Kreis, TE; Lippincott-Schwartz, J; Robbins, J; Seamon, KB; Sheetz, MP | 1 |
| Card, JP; Enquist, LW; Meade, RP; Robbins, AK; Whealy, ME | 1 |
| Chen, SY; Compans, RW; Matsuoka, Y | 1 |
| Banfield, BW; Cheung, P; Tufaro, F | 1 |
| Rose, JK; Ruusala, A; Zagouras, P | 1 |
| Palade, GE; Ulmer, JB | 3 |
| Lee, AS; Ou, JH; Wang, J | 1 |
| Madshus, IH; Olsnes, S; Sandvig, K; Stenmark, H | 1 |
| Chen, CC; Wu, HC; Yoshida, T; Zhang, MS | 1 |
| Berger, B; Berger, EG; Bosshart, H; Straehl, P | 1 |
| Schulz, I; Zeuzem, S; Zimmermann, P | 1 |
| Chaudhary, VK; FitzGerald, D; Pastan, I; Seetharam, S | 1 |
| Berger, B; Berger, EG; Bosshart, H; Geuze, HJ; Strous, GJ; van Kerkhof, P | 1 |
| Hong, W; Low, SH; Subramaniam, VN; Tan, P; Tang, BL; Wong, SH | 1 |
| Grillo, FG; Hudson, TH | 1 |
| Bachhawat, AK; Pillai, S | 1 |
| Hofmann, WJ; Koch, N; Moldenhauer, G; Möller, P | 1 |
| Arioka, M; Hirata, A; Takatsuki, A; Yamasaki, M | 1 |
| Chawla, D; Hughes, RC | 1 |
| Lucocq, JM; Mackay, D; Nilsson, T; Warren, G | 1 |
| Kakiuchi, T; Nariuchi, H; Takatsuki, A; Watanabe, M | 1 |
| Misteli, T; Moremen, K; Nakano, A; Roth, J; Zuber, C | 1 |
| Freeze, HH; Garcia, JA; Sampath, D; Spiro, RC | 1 |
| Donaldson, JG; Kahn, RA; Klausner, RD; Lippincott-Schwartz, J | 1 |
| Biddison, WE; Klausner, RD; Nuchtern, JG | 1 |
| Amherdt, M; Donaldson, JG; Klausner, RD; Lippincott-Schwartz, J; Orci, L; Perrelet, A; Rothman, JE; Tagaya, M | 1 |
| Aasman, EJ; Szarka, R; Vance, JE | 1 |
| Adorini, L; Fuchs, S; Hämmerling, GJ; Heuser, A; Momburg, F; Moreno, J; Nadimi, F | 1 |
| Beato, KE; Boissy, RE; Nordlund, JJ | 1 |
| Fujiwara, T; Ikehara, Y; Oda, K | 2 |
| Brown, MS; Goldstein, JL; Herz, J; Kowal, RC | 1 |
| Imanaka, T; Sato, R; Takano, T; Takatsuki, A | 1 |
| Chen, CH; Wu, HC; Yoshida, T; Zhang, MS | 1 |
| Chen, BP; Madrigal, A; Parham, P | 1 |
| Lechler-Osborn, S; Lutz, MS; Mills, SE; Young, WW | 1 |
| Klöppel, KD; Kneusel, RE; Matern, U; Wray, V | 1 |
| Bennink, JR; Cox, JH; Eisenlohr, LC; Johnson, PR; Yewdell, JW | 1 |
| Simoni, RD; Urbani, L | 1 |
| Fuller, S; Tooze, J; Vaux, D | 1 |
| Isobe, K; Kuzushima, K; Morishima, T; Nakashima, I; Takatsuki, A | 1 |
| Chege, NW; Pfeffer, SR | 1 |
| Berger, EG; Donaldson, JG; Hauri, HP; Klausner, RD; Lippincott-Schwartz, J; Schweizer, A; Yuan, LC | 1 |
| Kuwano, M; Mizoguchi, H; Ono, M; Seguchi, T; Shite, S | 1 |
| Dekker, J; Strous, GJ | 1 |
| Hasilik, A; Isidoro, C; Radons, J | 1 |
| Bar-Nun, S; Chun, KT; Simoni, RD | 1 |
| Fujiwara, T; Ikehara, Y; Oda, K; Takami, N | 1 |
| Bloom, GS; Donaldson, JG; Klausner, RD; Kreis, TE; Lippincott-Schwartz, J | 1 |
| Armstrong, J; Warren, G | 1 |
| Cozzolino, F; Rubartelli, A; Sitia, R; Talio, M | 1 |
| Iber, H; Sandhoff, K; Stotz, H; Takatsuki, A; van Echten, G | 1 |
| Katsumata, O; Takatsuki, A; Tamaki, H; Yamashina, S | 1 |
| Adorini, L; Appella, E; Fuchs, S; Ullrich, SJ | 1 |
| St-Pierre, Y; Watts, TH | 1 |
| Kuwano, M; Ono, M; Seguchi, T; Shimada, T; Shite, S | 1 |
| Jaraquemada, D; Long, EO; Marti, M | 1 |
| Ikehara, Y; Miki, K; Misumi, Y; Takatsuki, A; Tamura, G | 1 |
| Magner, JA; Papagiannes, E | 1 |
| Bennink, JR; Yewdell, JW | 1 |
| Magner, JA; Miura, Y; Perkel, VS | 1 |
| Ishii, S; Kariya, Y; Nagasawa, M; Yamamoto, H | 1 |
| Bonifacino, JS; Klausner, RD; Lippincott-Schwartz, J; Yuan, LC | 1 |
| Davey, J | 1 |
| Ito, S; Kato, S; Naito, H; Noguchi, T | 1 |
| Doms, RW; Russ, G; Yewdell, JW | 1 |
| Nishimura, Y; Oda, K | 1 |
| Biddison, WE; Bonifacino, JS; Klausner, RD; Nuchtern, JG | 1 |
| Liu, AY; Magner, JA; Miura, Y; Perkel, VS | 1 |
| Fujiwara, T; Ikehara, Y; Oda, K; Takatsuki, A; Yokota, S | 1 |
| Hirose, S; Ikehara, Y; Misumi, Y; Oda, K; Takami, N; Takatsuki, A | 1 |
| Matern, U; Tietjen, KG | 1 |
| Nozoe, S; Ohta, T; Sunagawa, M | 1 |
| Hunkler, D; Matern, U; Tietjen, KG | 1 |
| Jinnouchi, H; Yagishita, K; Yamamoto, H | 1 |
| Sam, CT | 2 |
| Jinnouchi, H; Yagishita, K | 1 |
| Cieplak, W; Grant, CC; Konkel, ME; Messer, RJ | 1 |
| Bajnath, RB; De Jonge, HR; Dekker, K; Groot, JA | 1 |
| Betina, V; Drgonová, J; Farkas, V; Kossaczká, Z; Podobová, B | 1 |
| Borén, J; Lindberg, K; Olofsson, SO; Rustaeus, S | 1 |
| Akashi, T; Homma, M; Kanbe, T; Tanaka, K | 1 |
| Benos, DJ; Cunningham, SA; Frizzell, RA; Morris, AP; Tousson, A | 1 |
| Molloy, SS; Stenberg, PE; Thomas, G; Thomas, L; VanSlyke, JK | 1 |
| Bobinski, J; Chan, H; Hammerschlag, R; Smith, RS; Snyder, RE | 1 |
| Morin, AM; Stanboli, A | 1 |
| Borghi, H; Bourguignon, J; Callé, A; Diarra-Mehrpour, M; Héron, A; Martin, JP; Sesboüé, R | 1 |
| Kopito, RR; Ward, CL | 1 |
| Salter, RD; Tector, M; Zhang, Q | 1 |
| Chou, CF; Omary, MB | 1 |
| Okazaki, K; Sano, S; Slomiany, A; Slomiany, BL; Yamamoto, Y | 1 |
| Janssen, R; Tommassen, J; UytdeHaag, FG; van Doornik, CE; Verjans, GM | 1 |
| Armant, DR; Schultz, JF | 1 |
| Karlsson, H; Nässberger, L | 1 |
| Shibaoka, H; Sonobe, S; Yasuhara, H | 1 |
| Bellé, R; Cormier, P; Drewing, S; Minella, O; Mulner-Lorillon, O; Poulhe, R; Schmalzing, G | 1 |
| Ardelt, W; D'Alessio, G; De Lorenzo, C; Gadina, M; Mikulski, SM; Saxena, SK; Wu, Y; Youle, RJ | 1 |
| Bennink, JR; Deng, Y; Haugland, RP; Kang, HC; Yewdell, JW | 1 |
| Crommie, D; Rosen, SD | 1 |
| Arreaza, G; Brown, DA | 1 |
| Maccioni, HJ; Rosales Fritz, VM | 1 |
| Farrer, RG; Quarles, RH; Warden, MP | 1 |
| Barthel, A; Nickel, W; Söling, HD; Tonko, C | 1 |
| Brown, WJ; de Figueiredo, P | 1 |
| Edgren, G; Fransson, LA; Havsmark, B; Schmidtchen, A | 1 |
| Clayton, L; Johnson, MH; McConnell, JM | 1 |
| Oda, T; Wu, HC | 3 |
| Aubery, M; Chazaud, B; Decastel, M; Muriel, MP | 2 |
| Kim, HL; Kochevar, J | 1 |
| Boukamel, R; Gloor, S; Keller, P; Semenza, G; Zecca, L; Zwicker, E | 1 |
| De Lemos-Chiarandini, C; Gravotta, D; Ivessa, NE; Kreibich, G; Sabatini, DD | 1 |
| Canu, N; Ciotti, T; Ferri, GL; Levi, A; Possenti, R; Rinaldi, AM; Trani, E | 1 |
| Bassotti, C; Benedetti, A; Guidarelli, C; Jezequel, AM; Marucci, L | 1 |
| Brown, BE; Elias, PM; Feingold, KR; Mao-Qiang, M; Wu-Pong, S | 1 |
| Law, GJ; Mason, WT; Northrop, AJ; Rupnik, M; Zorec, R | 1 |
| al-Jaufy, AY; Jackson, MP; King, SR | 1 |
| de Bolos, C; Degand, P; Delannoy, P; Hemon, B; Huet, G; Kim, I; Lo-Guidice, JM; Moreau, O; Real, FX; Richet, C | 1 |
| Braca, A; Colanzi, A; Corda, D; De Matteis, MA; Di Girolamo, M; Luini, A; Pawlak, D; Rasenick, MM; Silletta, MG | 1 |
| Andersson, LM; Warburton, MJ | 1 |
| Giudici, ML; Lopes-Cardozo, M; Magni, P; Marchesini, S; van der Bijl, P; van Golde, LM; Vos, JP | 1 |
| Franksson, L; Jondal, M; Lederer, E; Liu, T; Ljunggren, HG; Zhou, X | 1 |
| Barry, M; Boshkov, L; Lee, SF; McFadden, G | 1 |
| Uhlin-Hansen, L; Yanagishita, M | 2 |
| Rose, JK; Turi, TG | 1 |
| Josefsson, JO; Vult von Steyern, F | 1 |
| Kantanen, ML; Kuismanen, E; Leinikki, P | 1 |
| Burns, MP; Lebherz, WB; Majadly, FD; McCloud, TG; Miller, DA; Muschik, GM; Poole, KK; Roach, JM; Ross, JT | 1 |
| Bächi, T; Berger, EG; Burger, P; Hille, A | 1 |
| Yamashina, S | 1 |
| Gould-Fogerite, S; Mannino, RJ; Reston, JT | 1 |
| Boekelheide, K; Johnson, KJ | 1 |
| Brett, SJ; Liew, FY; Rhodes, J; Tite, JP | 1 |
| De Matteis, MA; Di Tullio, G; Kahn, RA; Luini, A; Santini, G | 1 |
| Bächi, T; Berger, EG; Bosshart, H; Grimm, K; Kleene, R; Watzele, M | 1 |
| Adorini, L; Busch, R; Drexler, J; Fuchs, S; Hämmerling, GJ; Momburg, F; Post, M | 1 |
| Goodenough, DA; Musil, LS | 1 |
| Amsler, K | 1 |
| Kanje, M; Tågerud, S; Vult von Steyern, F | 1 |
| Edwards, SN; Jalkanen, M; Miettinen, HM | 1 |
| Cerundolo, V; Elliott, T; Townsend, A; Willis, A | 1 |
| Audet, R; Drapeau, G; Marceau, F; Petitclerc, E; Rioux, F | 1 |
| Narula, N; Stow, JL | 1 |
| Lagace, TA; Ridgway, ND | 1 |
| Ansorge, I; Benting, J; Lingelbach, KR; Paprotka, K | 1 |
| Fliesler, SJ; Florman, R; Keller, RK | 1 |
| Bateman, JF; Byers, PH; Chan, D; Chessler, SD; Cole, WG; Golub, SB; Lamandé, SR; Sillence, DO | 1 |
| Kornfeld, S; Rohrer, J; Schweizer, A | 1 |
| Benlimame, N; Nabi, IR; Simard, D | 1 |
| Betina, V; Crabbe, MJ | 1 |
| Banno, T; Ikehara, Y; Murakami, K; Nakayama, K; Torii, S; Watanabe, T | 1 |
| Henne, C; Koch, N; Möller, P; Schwenk, F | 1 |
| Ansorge, I; Jeckel, D; Lingelbach, K; Wieland, F | 1 |
| Figueiredo, RC; Soares, MJ | 1 |
| Atwal, OS; Minhas, K; Singh, B | 1 |
| Kielty, CM; Raghunath, M; Steinmann, B | 1 |
| Brown, HA; Ktistakis, NT; Roth, MG; Sternweis, PC | 1 |
| Chandra, S; Morrison, GH; Ridsdale, AJ; Zha, X | 1 |
| Bajetto, A; Bonifaci, N; Di Blas, E; Rubartelli, A; Sitia, R; Solito, E | 1 |
| Melançon, P; Spiro, DJ; Taylor, TC; Wessling-Resnick, M | 1 |
| Boisvert, F; Checroune, F; Cohen, EA; Friborg, J; Gratton, S; Sékaly, RP; Yao, XJ | 1 |
| Plaas, AH; Wong-Palms, S | 1 |
| Kao, CY; Ktistakis, NT; Roth, MG; Wang, RH | 1 |
| Cid-Arregui, A; Dotti, CG; Parton, RG; Simons, K | 1 |
| Daum, G; Hechtberger, P | 1 |
| Bergeron, JJ; Chang, W; Gelman, MS; Prives, JM; Thomas, DY | 1 |
| Bassi, R; Riboni, L; Tettamanti, G | 1 |
| Romero, G; Shome, K; Xu, XQ | 1 |
| Kovacsovics-Bankowski, M; Rock, KL | 1 |
| Kochevar, DT; Mitchell, DM | 1 |
| Hitzel, C; Koch, N; van Endert, P | 1 |
| Schonhorn, JE; Wessling-Resnick, M | 1 |
| Alvaro, D; Bassotti, C; Benedetti, A; Bini, A; Capocaccia, L; Furfaro, S; Gigliozzi, A; Jezequel, AM; La Rosa, T | 1 |
| Morré, DJ | 1 |
| Grosenbach, D; Hruby, DE; Ulaeto, D | 1 |
| Herscovitz, H; Kritis, A; Small, DM; Talianidis, I; Zanni, E; Zannis, V | 1 |
| Buechler, RD; Florkiewicz, E; Florkiewicz, RZ; Majack, RA | 1 |
| Asada, H; Ishiura, S; Kawamura, Y; Maruyama, K; Obata, K; Tagawa, K | 1 |
| Barbieri, JT; Xu, Y | 1 |
| Chen, CH; Oda, T; Wu, HC | 1 |
| Brostrom, CO; Brostrom, MA; Gmitter, D; Prostko, CR | 1 |
| Lippincott-Schwartz, J; Luján, HD; Marotta, A; Mowatt, MR; Nash, TE; Sciaky, N | 1 |
| Donohue-Rolfe, A; Donta, ST; Tomicic, TK | 1 |
| Clermont, Y; Jackson, CL; Képès, F; Rambourg, A | 1 |
| Arioka, M; Kadokura, H; Nagao, K; Taguchi, Y; Takatsuki, A; Yamasaki, M; Yoda, K | 1 |
| Mendez, AJ | 1 |
| Jondal, M; Lederer, E; Liu, T; Ljunggren, HG; Orvell, C; Zhou, X | 1 |
| Ng, KL; Ng, ML; Sreenivasan, V | 1 |
| Barroso, M; Sztul, ES | 1 |
| Kalish, RS; LaPorte, A; Wood, JA | 1 |
| Barrand, MA; Rhodes, T; Twentyman, PR | 1 |
| Argon, Y; Dul, JL; Melnick, J | 1 |
| Benjamins, JA; Nedelkoska, L | 1 |
| Gonatas, NK; Lavi, E; Stieber, A; Wang, Q | 1 |
| van Leyen, K; Wieland, F | 1 |
| Rose, JK; Turi, TG; Webster, P | 1 |
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| Anderson, TJ; Gleeson, PA; Griffiths, G; Matheson, F; Stow, JL; Toh, BH | 1 |
| Berg, E; Eriksson, I; Kjellén, L; Kusche-Gullberg, M; Uhlin-Hansen, L | 1 |
| Barret, A; Muller, L; Picart, R; Tougard, C | 1 |
| Colton, TL; Wilson, JM | 1 |
| Mendez, AJ; Uint, L | 1 |
| Hicke, L; Pypaert, M; Riezman, H; Rohrer, J; Zanolari, B | 1 |
| Kornfeld, S; Liang, JO | 1 |
| Helenius, A; Tatu, U | 1 |
| Rabeck, C; Wolff, B; Zsak, M | 1 |
| Alamillo, JM; García-Olmedo, F; Romero, A | 1 |
| Daniotti, JL; Maccioni, HJ; Martina, JA; Maxzúd, MK; Rosales Fritz, V | 1 |
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| Adamik, R; Meacci, E; Moss, J; Tsai, SC; Vaughan, M | 1 |
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| Komatsu, N; Muramatsu, T; Oda, T | 2 |
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| Capell, A; Haass, C; Ihara, Y; Leimer, U; Steiner, H; Wild-Bode, C; Yamazaki, T | 1 |
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| Beyreuther, K; Cappai, R; Culvenor, JG; Davis, JB; Evin, G; Karran, EH; Maher, F; Malchiodi-Albedi, F; Masters, CL; Roberts, GW; Underwood, JR | 1 |
| Leventis, R; Nägele, E; Rex, S; Schelhaas, M; Schroeder, H; Silvius, JR; Waldmann, H | 1 |
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| Cheng, F; Fransson, LA; Moses, J; Oldberg, A | 1 |
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| Colanzi, A; Corda, D; De Matteis, MA; Di Tullio, G; Fiucci, G; Flati, S; Fusella, A; Luini, A; Malhotra, V; Mironov, A; Polishchuk, R; Silletta, MG; Weigert, R | 1 |
| Emery, G; Gruenberg, J; Kellner, R; Parton, RG; Pepperkok, R; Rojo, M; Stang, E | 1 |
| Cole, N; Lippincott-Schwartz, J; Moreira, JE; Presley, J; Sciaky, N; Siggia, E; Smith, C; Terasaki, M; Zaal, KJ | 1 |
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| Chen, Y; Konno, S; Mallouh, C; Mordente, JA; Tazaki, H; Wu, JM | 1 |
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| Bedford, PA; Brown, KA; Dumonde, DC; Knight, SC; Macey, MG; McCarthy, DA | 1 |
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| Abrami, L; Fivaz, M; Glauser, PE; Parton, RG; van der Goot, FG | 1 |
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| Chabane, S; Gachet, E; Képès, F | 1 |
| Ding, Y; Hakamata, H; Horiuchi, S; Kawano, T; Kawasaki, T; Matsuda, H; Miyazaki, A | 1 |
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| Bascans, E; Belloc, F; Bernard, P; Bilhou-Nabera, C; Boisseau, MR; Bonnefille, S; Labroille, G; Lacombe, F | 1 |
| Beckers, CJ; Dubremetz, JF; Joiner, KA; Karsten, V; Qi, H; Reddy, A; Webster, P | 1 |
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| Bhullar, RP; Fleming, N; Li, L; Mellow, L | 1 |
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| Calafat, J; Dusseljee, S; Janssen, H; Neefjes, J; Tulp, A; Verwoerd, D; Wubbolts, R | 1 |
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17 review(s) available for cyclopentane and brefeldin a
| Article | Year |
|---|---|
Now you see it, now you don't: the Golgi disappearing act.
Topics: Anti-Bacterial Agents; Biological Transport; Brefeldin A; Cyclopentanes; Endoplasmic Reticulum; Golgi Apparatus | 1992 |
Biological effects of the antibiotic brefeldin A (decumbin, cyanein, ascotoxin, synergisidin): a retrospective.
Topics: Animals; Antibiotics, Antineoplastic; Antifungal Agents; Antinematodal Agents; Antiviral Agents; Brefeldin A; Cyclopentanes; Humans; Plants | 1992 |
Brefeldin A and the endocytic pathway. Possible implications for membrane traffic and sorting.
Topics: Brefeldin A; Cell Membrane; Cyclopentanes; Endocytosis; Organelles | 1992 |
Recycling of proteins between the endoplasmic reticulum and Golgi complex.
Topics: Amino Acid Sequence; Animal Population Groups; Animals; Biological Transport; Brefeldin A; Cell Compartmentation; Cyclopentanes; Endoplasmic Reticulum; Fungal Proteins; Genes, Fungal; Glycosylation; Golgi Apparatus; Models, Biological; Molecular Sequence Data; Protein Processing, Post-Translational; Proteins; Receptors, Cell Surface; Receptors, Peptide; Saccharomyces cerevisiae | 1991 |
Brefeldin A: insights into the control of membrane traffic and organelle structure.
Topics: Animals; Brefeldin A; Cell Compartmentation; Cyclopentanes; Endoplasmic Reticulum; Golgi Apparatus; Intracellular Membranes; Organelles | 1992 |
Relationships between sorting in the exocytic and endocytic pathways of MDCK cells.
Topics: Brefeldin A; Cell Line; Cell Polarity; Cyclopentanes; Endocytosis; Epithelium; Exocytosis; Humans; Membrane Proteins; Microtubules | 1991 |
Multiple targets for brefeldin A.
Topics: Animals; Biological Transport; Brefeldin A; Cell Compartmentation; Cyclopentanes; Endoplasmic Reticulum; Golgi Apparatus; Intracellular Membranes; Membrane Proteins; Organelles | 1991 |
Sorting out the secretory pathway.
Topics: Amino Acid Sequence; Animals; Brefeldin A; Cyclopentanes; Endocytosis; Endoplasmic Reticulum; Golgi Apparatus; Humans; Molecular Sequence Data; Proteins | 1989 |
Dynamic structure and function of Golgi apparatus in the salivary acinar cells.
Topics: Animals; Awards and Prizes; Brefeldin A; Carcinogens; Cyclopentanes; Ethers, Cyclic; Golgi Apparatus; Humans; Image Processing, Computer-Assisted; Japan; Microscopy, Electron; Microtubules; Mitosis; Monensin; Okadaic Acid; Protein Synthesis Inhibitors; Salivary Glands; Societies, Scientific | 1995 |
Hormone- and growth factor-stimulated NADH oxidase.
Topics: Animals; Brefeldin A; Cyclopentanes; Cystine; Enzyme Activation; Golgi Apparatus; Growth Substances; HeLa Cells; Hormones; Humans; Intracellular Membranes; Membrane Proteins; Mitosis; Models, Biological; Multienzyme Complexes; NADH, NADPH Oxidoreductases; Neoplasm Proteins; Plant Proteins; Protein Disulfide Reductase (Glutathione); Rats | 1994 |
Transport and internal organization of membranes: vesicles, membrane networks and GTP-binding proteins.
Topics: Biological Evolution; Biological Transport; Brefeldin A; Cell Compartmentation; Cell Polarity; Cell-Free System; Cyclopentanes; Endocytosis; Eukaryotic Cells; Exocytosis; Golgi Apparatus; GTP-Binding Proteins; Guanosine Triphosphate; Intracellular Membranes; Macromolecular Substances; Membrane Fusion; Models, Biological; Protein Processing, Post-Translational | 1994 |
[Inhibitors of intracellular translocation of glycoproteins].
Topics: 1-Deoxynojirimycin; Animals; Bacteria; Biological Transport; Brefeldin A; Cyclopentanes; Cytoskeleton; Depression, Chemical; Glycoproteins; Hydrogen-Ion Concentration; Monensin; Nocodazole; Organelles; Tunicamycin | 1993 |
Biogenesis of constitutive secretory vesicles, secretory granules and synaptic vesicles.
Topics: Biopolymers; Brefeldin A; Cyclopentanes; Cytoplasmic Granules; Golgi Apparatus; GTP-Binding Proteins; Membrane Proteins; Protein Synthesis Inhibitors; Proteins; Synaptic Vesicles | 1993 |
Biosynthesis of sphingomyelin and its delivery to the surface of baby hamster kidney (BHK) cells.
Topics: Animals; Brefeldin A; Cell Line; Cell Membrane; Ceramides; Cricetinae; Cyclopentanes; Golgi Apparatus; Kidney; Membrane Lipids; Monensin; Sphingomyelin Phosphodiesterase; Sphingomyelins | 1993 |
Brefeldin A effects in plant and fungal cells: something new about vesicle trafficking?
Topics: Biological Transport; Brefeldin A; Cyclopentanes; Fungi; Golgi Apparatus; Intracellular Membranes; Plants; Protein Synthesis Inhibitors | 1996 |
Compartmental organization of ganglioside synthesis in the Golgi complex.
Topics: Animals; Brefeldin A; Cell Compartmentation; Cell Fractionation; Chick Embryo; Coated Vesicles; Cyclopentanes; Gangliosides; Golgi Apparatus; Ionophores; Membrane Proteins; Monensin | 1996 |
TGN38 and its orthologues: roles in post-TGN vesicle formation and maintenance of TGN morphology.
Topics: Amino Acid Sequence; Animals; Brefeldin A; Cell Membrane; Cells, Cultured; Cyclopentanes; Cytosol; Fluorescent Antibody Technique; Gene Expression Regulation; Glycoproteins; Golgi Apparatus; Membrane Glycoproteins; Membrane Proteins; Molecular Sequence Data; Phosphorylation | 1997 |
831 other study(ies) available for cyclopentane and brefeldin a
| Article | Year |
|---|---|
Antigen presentation by Toxoplasma-infected cells: antigen entry through cell membrane fusion.
Topics: Animals; Antigen-Presenting Cells; Antigens, Protozoan; Brefeldin A; Cyclopentanes; Cytotoxicity, Immunologic; Humans; Immunity, Cellular; Microscopy, Electron; T-Lymphocytes, Cytotoxic; Toxoplasma; Toxoplasmosis; Tumor Cells, Cultured | 1992 |
Newly synthesized class II MHC chains are required for VSV G presentation to CTL clones.
Topics: Ammonium Chloride; Animals; Antigen-Presenting Cells; Antigens, Viral; Brefeldin A; Chloroquine; Clone Cells; Cyclopentanes; Emetine; Glycoproteins; Histocompatibility Antigens Class II; Lymphocyte Cooperation; Membrane Glycoproteins; Mice; Recombinant Proteins; Solubility; T-Lymphocytes, Cytotoxic; Vesicular stomatitis Indiana virus; Viral Envelope Proteins | 1992 |
RMA/S cells present endogenously synthesized cytosolic proteins to class I-restricted cytotoxic T lymphocytes.
Topics: Animals; Antiviral Agents; Brefeldin A; Capsid; Cell Line; Cycloheximide; Cyclopentanes; Cytosol; Cytotoxicity, Immunologic; Histocompatibility Antigens Class I; Influenza A virus; Lymphocyte Activation; Mice; Mice, Inbred C57BL; Mice, Inbred CBA; Mice, Inbred Strains; Nucleocapsid Proteins; Nucleoproteins; RNA-Binding Proteins; Species Specificity; T-Lymphocytes, Cytotoxic; Vesicular stomatitis Indiana virus; Viral Core Proteins | 1992 |
Inhibition of poliovirus RNA synthesis by brefeldin A.
Topics: Adenoviridae; Antiviral Agents; Brefeldin A; Cyclopentanes; Fluorescent Antibody Technique; HeLa Cells; Humans; Kinetics; Lipids; Poliovirus; Protein Biosynthesis; RNA, Viral; Virus Replication | 1992 |
Disruptions in intracellular membrane trafficking and structure preclude the glucocorticoid-dependent maturation of mouse mammary tumor virus proteins in rat hepatoma cells.
Topics: Animals; Biological Transport; Blotting, Western; Brefeldin A; Cyclopentanes; Electrophoresis, Polyacrylamide Gel; Endoplasmic Reticulum; Fluorescent Antibody Technique; Gene Expression; Glucocorticoids; Golgi Apparatus; Hydrolysis; Intracellular Membranes; Liver Neoplasms, Experimental; Mammary Tumor Virus, Mouse; Phosphoproteins; Plasmids; Precipitin Tests; Protein Processing, Post-Translational; Rats; Transfection; Tumor Cells, Cultured; Viral Envelope Proteins | 1992 |
Contact allergens modulate the expression of MHC class II molecules on murine epidermal Langerhans cells by endocytotic mechanisms.
Topics: Allergens; Animals; Antibodies, Monoclonal; Brefeldin A; Cyclopentanes; Dermatitis, Contact; Endocytosis; Female; Histocompatibility Antigens Class II; Hypertonic Solutions; Langerhans Cells; Male; Mice; Mice, Inbred BALB C; Monensin | 1992 |
A brefeldin A-like phenotype is induced by the overexpression of a human ERD-2-like protein, ELP-1.
Topics: Amino Acid Sequence; Base Sequence; Brefeldin A; Carrier Proteins; Cell Compartmentation; Cloning, Molecular; Cyclopentanes; Endocytosis; Gene Expression; Golgi Apparatus; GTP-Binding Proteins; Humans; Membrane Proteins; Molecular Sequence Data; Oligodeoxyribonucleotides; Phenotype; Protein Processing, Post-Translational; Proteins; Receptors, Cell Surface; Sequence Alignment; Solubility; Transfection; Vesicular Transport Proteins | 1992 |
Brefeldin A affects the cellular distribution of endocytic receptors differentially.
Topics: Asialoglycoprotein Receptor; Asialoglycoproteins; Brefeldin A; Carcinoma, Hepatocellular; Cyclopentanes; Down-Regulation; Endocytosis; Humans; Liver Neoplasms; Mannosephosphates; Receptor, IGF Type 2; Receptors, Cell Surface; Receptors, Immunologic; Receptors, Transferrin; Transferrin; Tumor Cells, Cultured; Up-Regulation | 1992 |
Inhibition of human cytomegalovirus maturation by brefeldin A.
Topics: Antiviral Agents; Biological Transport; Brefeldin A; Cell Compartmentation; Cells, Cultured; Cyclopentanes; Cytomegalovirus; DNA Replication; Dose-Response Relationship, Drug; Fibroblasts; Golgi Apparatus; Hexosaminidases; Humans; Male; Morphogenesis; Nuclear Envelope; Penis; Protein Processing, Post-Translational; Skin; Time Factors; Viral Envelope Proteins; Virus Replication | 1992 |
Involvement of membrane traffic in the replication of poliovirus genomes: effects of brefeldin A.
Topics: Antiviral Agents; Biological Transport; Brefeldin A; Cyclopentanes; DNA, Viral; Genome, Viral; Golgi Apparatus; HeLa Cells; Humans; Intracellular Membranes; Kinetics; Phospholipids; Poliovirus; RNA, Viral; Viral Proteins; Virus Replication; Viruses | 1992 |
Studies on endoplasmic reticulum--Golgi complex cycling pathway in herpes simplex virus-infected and brefeldin A-treated human fibroblast cells.
Topics: Animals; Antiviral Agents; Biological Transport; Brefeldin A; Capsid; Cell Line; Cells, Cultured; Chlorocebus aethiops; Cyclopentanes; Endoplasmic Reticulum; Fibroblasts; Glycoproteins; Golgi Apparatus; Humans; Microscopy, Electron; Simplexvirus; Viral Envelope Proteins; Viral Proteins; Virus Replication | 1992 |
Roles of heme insertion and the mannose-6-phosphate receptor in processing of the human myeloid lysosomal enzyme, myeloperoxidase.
Topics: Brefeldin A; Cyclopentanes; Endoplasmic Reticulum; Glycosylation; Golgi Apparatus; Heme; Heptanoates; Humans; Immunosorbent Techniques; Kinetics; Lysosomes; Microscopy, Electron; Microscopy, Immunoelectron; Neutrophils; Peroxidase; Phosphorylation; Protein Precursors; Receptor, IGF Type 2; Tumor Cells, Cultured | 1992 |
Secretion of thioredoxin by normal and neoplastic cells through a leaderless secretory pathway.
Topics: Animals; B-Lymphocytes; Brefeldin A; Cell Line; Cells, Cultured; Cyclopentanes; Endoplasmic Reticulum; Escherichia coli; Golgi Apparatus; Humans; Interleukin-1; Kinetics; L-Lactate Dehydrogenase; Lipopolysaccharides; Lymphocyte Activation; Promoter Regions, Genetic; Recombinant Proteins; Simian virus 40; T-Lymphocytes; Thioredoxins; Transfection; Tumor Cells, Cultured | 1992 |
Selective inhibition of protein targeting to the apical domain of MDCK cells by brefeldin A.
Topics: Animals; Biological Transport; Brefeldin A; Cadherins; Cell Membrane; Cell Polarity; Cells, Cultured; Cyclopentanes; Dipeptidyl Peptidase 4; Dipeptidyl-Peptidases and Tripeptidyl-Peptidases; Dogs; Endoplasmic Reticulum; Exocytosis; Golgi Apparatus; Sialic Acids | 1992 |
Synthesis and trafficking of prion proteins in cultured cells.
Topics: Animals; Antibodies; Biological Transport; Blotting, Western; Brain; Brefeldin A; Cell Membrane; Cells, Cultured; Cricetinae; Cyclopentanes; Electrophoresis, Polyacrylamide Gel; Endoplasmic Reticulum; Mannosyl-Glycoprotein Endo-beta-N-Acetylglucosaminidase; Mice; Neuroblastoma; Precipitin Tests; Prions; Protein Biosynthesis; Protein Precursors; PrPSc Proteins; Scrapie; Tumor Cells, Cultured | 1992 |
Gonocytes of male rats resume migratory activity postnatally.
Topics: Animals; Brefeldin A; Cell Movement; Cyclopentanes; Fluorescent Dyes; Germ Cells; Golgi Apparatus; Male; Monensin; Nocodazole; Paclitaxel; Rats; Rats, Sprague-Dawley; Testis | 1992 |
Use of Brefeldin A to localize block in intracellular transport of vesicular stomatitis virus G protein on interferon-treated cells.
Topics: Animals; Biological Transport, Active; Brefeldin A; Cyclopentanes; Fluorescent Antibody Technique; Golgi Apparatus; Interferons; L Cells; Membrane Glycoproteins; Mice; Vesicular stomatitis Indiana virus; Viral Envelope Proteins; Virus Diseases | 1992 |
Immunolocalization, quantitation and cellular heterogeneity of apolipoprotein B in rat hepatocytes.
Topics: Animals; Apolipoproteins B; Brefeldin A; Cells, Cultured; Cyclopentanes; Flow Cytometry; Fluorescent Antibody Technique; Golgi Apparatus; Liver; Male; Phycoerythrin; Rats; Rats, Inbred Strains; Staining and Labeling | 1992 |
Characterization of the adenovirus E3 protein that down-regulates the epidermal growth factor receptor. Evidence for intermolecular disulfide bonding and plasma membrane localization.
Topics: Adenovirus Early Proteins; Amino Acid Sequence; Brefeldin A; Cell Membrane; Cyclopentanes; Disulfides; Down-Regulation; Electrophoresis, Gel, Two-Dimensional; Electrophoresis, Polyacrylamide Gel; Epitopes; ErbB Receptors; Humans; Molecular Sequence Data; Oncogene Proteins, Viral; Plasmids; Precipitin Tests; Protein Conformation; Tumor Cells, Cultured | 1992 |
Common peptide epitopes in glycophorin and the endothelial sialoglycoprotein gp60.
Topics: Animals; Antibody Specificity; Brefeldin A; Carbohydrate Conformation; Carbohydrates; Cattle; Cell Line; Cyclopentanes; Endothelium; Endothelium, Vascular; Epitopes; Glycophorins; Humans; Hydrogen-Ion Concentration; Hydrolysis; Immune Sera; Immunosorbent Techniques; Male; Mice; Polysaccharides; Protein Biosynthesis; Protein Precursors; Proteins; Rats; RNA, Messenger; Sialoglycoproteins | 1992 |
Induction of syngeneic cytotoxic T lymphocytes against a B cell tumor. III. MHC class I-restricted CTL recognizes the processed form(s) of idiotype.
Topics: Animals; Antigen-Presenting Cells; Brefeldin A; Chloroquine; Cyclopentanes; Histocompatibility Antigens Class I; Immunoglobulin Idiotypes; Lymphoma, B-Cell; Mice; Mice, Inbred BALB C; Receptors, Antigen, B-Cell; Receptors, Antigen, T-Cell; T-Lymphocytes, Cytotoxic | 1992 |
Novel monoclonal antibody mAb G3A5 recognizes 138-kDa glycoprotein localized on the Golgi membrane.
Topics: Animals; Antibodies, Monoclonal; Brefeldin A; Cattle; Cells, Cultured; Cyclopentanes; Fluorescent Antibody Technique; Glycoside Hydrolases; Golgi Apparatus; Haplorhini; HeLa Cells; Humans; Immunoblotting; Kidney; Membrane Glycoproteins; Mice; Molecular Weight; Nocodazole | 1992 |
Human autoantibodies as reagents to conserved Golgi components. Characterization of a peripheral, 230-kDa compartment-specific Golgi protein.
Topics: 3T3 Cells; Animals; Autoantibodies; Autoantigens; Brefeldin A; Cyclopentanes; Fluorescent Antibody Technique; Golgi Apparatus; HeLa Cells; Humans; Immunoenzyme Techniques; Membrane Proteins; Mice; Precipitin Tests; Sjogren's Syndrome | 1992 |
Degradation of secretory immunoglobulin M in B lymphocytes occurs in a postendoplasmic reticulum compartment and is mediated by a cysteine protease.
Topics: Animals; B-Lymphocytes; Brefeldin A; Cell Line; Cyclopentanes; Cysteine Endopeptidases; Diamide; Endoplasmic Reticulum; Glycosylation; Golgi Apparatus; Hybridomas; Immunoglobulin M; Kinetics; Methionine; Mice; Nocodazole; Sulfur Radioisotopes; Swainsonine | 1992 |
Staphylococcal ADP-ribosyltransferase-sensitive small G protein is involved in brefeldin A action.
Topics: Animals; Antifungal Agents; Bacterial Proteins; Brefeldin A; Cell Line; Coatomer Protein; Cyclopentanes; Drug Resistance; Golgi Apparatus; GTP-Binding Proteins; Intracellular Membranes; Membrane Proteins; Microscopy, Fluorescence; Microtubule-Associated Proteins; Poly(ADP-ribose) Polymerases; Staphylococcus aureus; Vero Cells | 1992 |
Effects of brefeldin A on endocytosis, transcytosis and transport to the Golgi complex in polarized MDCK cells.
Topics: Animals; Anti-Bacterial Agents; Biological Transport; Biomarkers; Brefeldin A; Cell Compartmentation; Cell Polarity; Cells, Cultured; Cyclopentanes; Dogs; Endocytosis; Golgi Apparatus; Lysosomes; Organelles; Ricin | 1992 |
The morphology but not the function of endosomes and lysosomes is altered by brefeldin A.
Topics: Adenosine Triphosphate; Animals; Anti-Bacterial Agents; Biological Transport; Biomarkers; Brefeldin A; Cathepsin D; Cell Compartmentation; Cells, Cultured; Cyclopentanes; Endocytosis; Energy Metabolism; Humans; Immunohistochemistry; Kinetics; Lysosomes; Microtubules; Organelles; Subcellular Fractions | 1992 |
Bacterial ADP-ribosyltransferase with a substrate specificity of the rho protein disassembles the Golgi apparatus in Vero cells and mimics the action of brefeldin A.
Topics: 4-Chloro-7-nitrobenzofurazan; Adenosine Diphosphate Ribose; Animals; Bacterial Proteins; Biomarkers; Brefeldin A; Ceramides; Coatomer Protein; Colforsin; Cyclopentanes; Golgi Apparatus; Guanosine 5'-O-(3-Thiotriphosphate); Mannosidases; Microtubule-Associated Proteins; Poly(ADP-ribose) Polymerases; Rho Factor; Staphylococcus aureus; Substrate Specificity; Vero Cells | 1992 |
Tunicamycin, puromycin and brefeldin A influence the subcellular distribution of neuropeptides in hypothalamic magnocellular neurones of rat.
Topics: Animals; Anti-Bacterial Agents; Brefeldin A; Cyclopentanes; Dose-Response Relationship, Drug; Endoplasmic Reticulum; Golgi Apparatus; Hypothalamus; Microscopy, Electron; Mitochondria; Neurons; Neuropeptides; Oxytocin; Puromycin; Rats; Rats, Inbred BB; Tunicamycin; Vasopressins | 1992 |
A Golgi-related structure remains after the brefeldin A-induced formation of an ER-Golgi hybrid compartment.
Topics: Brefeldin A; Cell Compartmentation; Cell Size; Cyclopentanes; Endoplasmic Reticulum; Golgi Apparatus; HeLa Cells; Humans; Immunohistochemistry; Membrane Proteins | 1992 |
Golgi proteins persist in the tubulovesicular remnants found in brefeldin A-treated pancreatic acinar cells.
Topics: Animals; Brefeldin A; Cells, Cultured; Cyclopentanes; Galactosyltransferases; Golgi Apparatus; Mannosidases; Microsomes; Pancreas; Rats | 1992 |
Presence of Golgi remnant membranes in the cytoplasm of brefeldin A-treated cells.
Topics: Animals; Brefeldin A; Cartilage; Cells, Cultured; Chick Embryo; Cyclopentanes; Cytoplasm; Glycosaminoglycans; Golgi Apparatus; Intracellular Membranes; Kidney; Mannosidases; Mitosis; Models, Biological; Rats; Thiamine Pyrophosphatase | 1992 |
Evidence that globular Golgi clusters in mitotic HeLa cells are clustered tubular endosomes.
Topics: Brefeldin A; Cyclopentanes; Endocytosis; Ethers, Cyclic; Galactosyltransferases; Golgi Apparatus; HeLa Cells; Horseradish Peroxidase; Humans; Mitosis; Okadaic Acid; Transferrin | 1992 |
Identification and partial characterization of a hepatocyte-derived factor promoting proliferation of cultured fat-storing cells (parasinusoidal lipocytes).
Topics: Animals; Brefeldin A; Cell Communication; Cell Division; Cells, Cultured; Culture Media; Cycloheximide; Cyclopentanes; DNA; Edetic Acid; Extracellular Matrix Proteins; Hydrogen-Ion Concentration; Lipid Metabolism; Liver; Male; Mitogens; Molecular Weight; Proteins; Proteoglycans; Rats; Rats, Sprague-Dawley | 1992 |
Studies of the sites of intracellular degradation of apolipoprotein B in Hep G2 cells.
Topics: Albumins; Apolipoproteins B; Biological Transport; Brefeldin A; Cholesterol Esters; Cyclopentanes; Endopeptidases; Endoplasmic Reticulum; Golgi Apparatus; Humans; In Vitro Techniques; Liver; Microsomes, Liver; Monensin; Nocodazole; Oleic Acid; Oleic Acids; Tumor Cells, Cultured | 1992 |
Sulfation of the human immunodeficiency virus envelope glycoprotein.
Topics: Antiviral Agents; Brefeldin A; Cell Line; Cyclopentanes; Gene Products, env; HIV Envelope Protein gp120; HIV Envelope Protein gp160; HIV Envelope Protein gp41; HIV-1; HIV-2; Humans; Macromolecular Substances; Protein Precursors; Simian Immunodeficiency Virus; Sulfates; Sulfur Radioisotopes; Vaccinia virus; Viral Envelope Proteins | 1992 |
Human immunodeficiency virus type 1 Vpu protein induces rapid degradation of CD4.
Topics: Antiviral Agents; Brefeldin A; CD4 Antigens; Cyclopentanes; DNA; DNA, Viral; Down-Regulation; Endoplasmic Reticulum; Gene Products, env; HeLa Cells; HIV-1; Human Immunodeficiency Virus Proteins; Humans; Kinetics; Plasmids; Transfection; Viral Regulatory and Accessory Proteins | 1992 |
Oxidation of brefeldin A.
Topics: Animals; Antibiotics, Antineoplastic; Brefeldin A; Candida albicans; Cell Survival; Cyclopentanes; Leukemia P388; Magnetic Resonance Spectroscopy; Microbial Sensitivity Tests; Oxidation-Reduction | 1992 |
Effects of cycloheximide, brefeldin A, suramin, heparin and primaquine on proteoglycan and glycosaminoglycan biosynthesis in human embryonic skin fibroblasts.
Topics: Anti-Bacterial Agents; Brefeldin A; Cells, Cultured; Chromatography, Gel; Cycloheximide; Cyclopentanes; Electrophoresis, Polyacrylamide Gel; Fibroblasts; Heparin; Humans; Polysaccharides; Primaquine; Skin; Suramin | 1992 |
Maturation of human lactase-phlorizin hydrolase. Proteolytic cleavage of precursor occurs after passage through the Golgi complex.
Topics: alpha 1-Antitrypsin; beta-Galactosidase; Brefeldin A; Cells, Cultured; Cyclopentanes; Glycosylation; Golgi Apparatus; Humans; In Vitro Techniques; Intestine, Small; Lactase; Lactase-Phlorizin Hydrolase; Membrane Glycoproteins; Microvilli; Molecular Weight; Multienzyme Complexes; Protein Precursors; Protein Processing, Post-Translational; Temperature | 1992 |
Polymerization of secretory IgM in B lymphocytes is prevented by a prior targeting to a degradation pathway.
Topics: Animals; Anti-Bacterial Agents; B-Lymphocytes; Brefeldin A; Cell Line; Cyclopentanes; Electrophoresis, Polyacrylamide Gel; Galactose; Immunoglobulin M; Macromolecular Substances; Methionine; Mice; Monensin; Oligosaccharides; Protein Processing, Post-Translational; Temperature | 1992 |
Brefeldin A inhibits Golgi membrane-catalysed exchange of guanine nucleotide onto ARF protein.
Topics: ADP-Ribosylation Factors; Animals; Brefeldin A; CHO Cells; Cricetinae; Cyclopentanes; Golgi Apparatus; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Triphosphate; Humans; Intracellular Membranes; Recombinant Proteins; Trypsin | 1992 |
Inhibition by brefeldin A of a Golgi membrane enzyme that catalyses exchange of guanine nucleotide bound to ARF.
Topics: ADP-Ribosylation Factors; Animals; Brefeldin A; Coatomer Protein; Cyclopentanes; Golgi Apparatus; GTP-Binding Proteins; Guanine Nucleotides; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Diphosphate; Guanosine Triphosphate; Guanylyl Imidodiphosphate; Intracellular Membranes; Liver; Membrane Proteins; Microtubule-Associated Proteins; Rats; Recombinant Proteins | 1992 |
Reorganization of the Golgi complex in association with mitosis: redistribution of mannosidase II to the endoplasmic reticulum and effects of brefeldin A.
Topics: Animals; Biological Transport; Brefeldin A; Cell Line; CHO Cells; Cricetinae; Cyclopentanes; Endoplasmic Reticulum; Golgi Apparatus; Immunohistochemistry; Mannosidases; Mice; Microtubules; Mitosis; Models, Biological; Nocodazole | 1992 |
Non-lysosomal degradation of misfolded human lysozymes with and without an asparagine-linked glycosylation site.
Topics: Animals; Asparagine; Base Sequence; Binding Sites; Brefeldin A; Carbohydrate Conformation; Cyclopentanes; Disulfides; Fluorescent Antibody Technique; Gene Expression; Glycosylation; Humans; L Cells; Mice; Molecular Sequence Data; Muramidase; Mutagenesis, Site-Directed; Protein Folding; Protein Processing, Post-Translational; Transfection; Vero Cells | 1992 |
Isolation and characterization of a brefeldin A-resistant mutant of monkey kidney Vero cells.
Topics: Adenosine Triphosphate; Animals; Antifungal Agents; Azides; Brefeldin A; Cyclopentanes; Deoxyglucose; Drug Resistance; Genes, Dominant; Golgi Apparatus; Mannosidases; Mutation; Proteins; Ricin; Sodium Azide; Vero Cells | 1992 |
Post-translational processing of an O-glycosylated protein, the human CD8 glycoprotein, during the intracellular transport to the plasma membrane.
Topics: Animals; Brefeldin A; Carbohydrate Sequence; CD8 Antigens; Cell Line; Cell Membrane; Cyclopentanes; Cysteine; Glycosylation; Glycosyltransferases; Humans; Kinetics; Molecular Sequence Data; Monensin; Neuraminidase; Protein Processing, Post-Translational; Rats; Substrate Specificity; Temperature; Transfection | 1992 |
Brefeldin A induced inhibition of de novo globo- and neolacto-series glycolipid core chain biosynthesis in human cells. Evidence for an effect on beta 1-->4galactosyltransferase activity.
Topics: Anti-Bacterial Agents; Brefeldin A; Carbohydrate Sequence; Ceramides; Chromatography, Thin Layer; Cyclopentanes; Globosides; Glycolipids; Golgi Apparatus; Hexosyltransferases; Humans; Kinetics; Molecular Sequence Data; N-Acetyllactosamine Synthase; Radioimmunoassay; Serine; Tumor Cells, Cultured | 1992 |
Golgi-localized beta-galactoside alpha 2,6-sialyltransferase in transfected CHO cells is redistributed into the endoplasmic reticulum by brefeldin A.
Topics: Animals; beta-D-Galactoside alpha 2-6-Sialyltransferase; Brefeldin A; CHO Cells; Cricetinae; Cyclopentanes; Endoplasmic Reticulum; Golgi Apparatus; Immunohistochemistry; Sialyltransferases | 1992 |
The trans-Golgi network can be dissected structurally and functionally from the cisternae of the Golgi complex by brefeldin A.
Topics: Brefeldin A; Cell Line; Cyclopentanes; Glycoproteins; Golgi Apparatus; Membrane Glycoproteins; Membrane Proteins | 1992 |
Brefeldin A inhibits protein synthesis in cultured cells.
Topics: ADP Ribose Transferases; Animals; Bacterial Toxins; Brefeldin A; CHO Cells; Cricetinae; Cyclopentanes; Exotoxins; Golgi Apparatus; Humans; Kinetics; Mice; Protein Synthesis Inhibitors; Pseudomonas aeruginosa Exotoxin A; Rats; Tumor Cells, Cultured; Virulence Factors | 1992 |
Effects of brefeldin A on de novo synthesis of lipids in BHK21-cells.
Topics: Animals; Anti-Bacterial Agents; Brefeldin A; Cell Line; Cricetinae; Cyclopentanes; Endoplasmic Reticulum; Golgi Apparatus; Lipids; Sphingomyelins | 1992 |
Recycling pathways of glucosylceramide in BHK cells: distinct involvement of early and late endosomes.
Topics: Animals; Biological Transport; Brefeldin A; Cricetinae; Cyclopentanes; Endocytosis; Fibroblasts; Fluorescent Dyes; Glucosylceramides; Golgi Apparatus; Kidney; Membrane Lipids; Mesocricetus; Microtubules; Models, Biological; Monensin; Time Factors | 1992 |
Brefeldin A inhibits the formation of constitutive secretory vesicles and immature secretory granules from the trans-Golgi network.
Topics: Animals; Brefeldin A; Cell Membrane; Cell-Free System; Centrifugation, Density Gradient; Cyclopentanes; Cytoplasmic Granules; Golgi Apparatus; PC12 Cells; Subcellular Fractions; Sulfur Radioisotopes | 1992 |
Brefeldin A affects early events but does not affect late events along the exocytic pathway in pancreatic acinar cells.
Topics: alpha-Amylases; Animals; Brefeldin A; Carbachol; Cyclopentanes; Cytoplasmic Granules; Endoplasmic Reticulum; Exocytosis; Golgi Apparatus; In Vitro Techniques; Kinetics; Male; Microscopy, Electron; Mycotoxins; Pancreas; Proteins; Rats | 1992 |
Proaleurain vacuolar targeting is mediated by short contiguous peptide interactions.
Topics: Amino Acid Sequence; Base Sequence; Biological Transport; Brefeldin A; Cells, Cultured; Cyclopentanes; Cysteine Endopeptidases; DNA; Enzyme Precursors; Molecular Sequence Data; Peptides; Plant Proteins; Protoplasts; Sequence Alignment; Vacuoles | 1992 |
In AtT20 and HeLa cells brefeldin A induces the fusion of tubular endosomes and changes their distribution and some of their endocytic properties.
Topics: Brefeldin A; Cell Line; Cyclopentanes; Endocytosis; Golgi Apparatus; HeLa Cells; Horseradish Peroxidase; Humans; Microscopy, Electron; Microscopy, Fluorescence; Microtubules; Nocodazole; Organelles; Receptors, Transferrin; Synaptophysin | 1992 |
Brefeldin A inhibits protein secretion and parasite maturation in the ring stage of Plasmodium falciparum.
Topics: Animals; Brefeldin A; Cyclopentanes; Erythrocytes; Humans; In Vitro Techniques; Kinetics; Malaria, Falciparum; Mycotoxins; Plasmodium falciparum; Protozoan Proteins | 1992 |
Brefeldin A, thapsigargin, and AIF4- stimulate the accumulation of GRP78 mRNA in a cycloheximide dependent manner, whilst induction by hypoxia is independent of protein synthesis.
Topics: 3T3 Cells; Aluminum; Aluminum Compounds; Animals; Brefeldin A; Carrier Proteins; Cell Hypoxia; Cycloheximide; Cyclopentanes; Endoplasmic Reticulum Chaperone BiP; Ethers, Cyclic; Fluorides; Fluorine; Genistein; Heat-Shock Proteins; HSP70 Heat-Shock Proteins; Isoflavones; Membrane Proteins; Mice; Molecular Chaperones; Okadaic Acid; Protein Biosynthesis; RNA, Messenger; Terpenes; Thapsigargin | 1992 |
Effect of reduced temperatures and brefeldin A on prolactin secretion and on subcellular distribution of the secretory product and membrane antigens in GH3 pituitary cells.
Topics: Animals; Antigens, Surface; Biological Transport, Active; Brefeldin A; Clone Cells; Cold Temperature; Cyclopentanes; Endoplasmic Reticulum; Golgi Apparatus; Microscopy, Electron; Pituitary Gland; Prolactin | 1992 |
Soluble aggregates of the human PiZ alpha 1-antitrypsin variant are degraded within the endoplasmic reticulum by a mechanism sensitive to inhibitors of protein synthesis.
Topics: 1-Deoxynojirimycin; 2,4-Dinitrophenol; alpha 1-Antitrypsin; Animals; Brefeldin A; Cycloheximide; Cyclopentanes; Dinitrophenols; Electrophoresis, Polyacrylamide Gel; Endoplasmic Reticulum; Glucosamine; Golgi Apparatus; Humans; Liver Neoplasms, Experimental; Mice; Nocodazole; Protein Synthesis Inhibitors; Puromycin; Transfection; Tumor Cells, Cultured | 1992 |
Human cathepsin D precursor is associated with a 60 kDa glycosylated polypeptide.
Topics: 1-Deoxynojirimycin; Brefeldin A; Calcitriol; Cathepsin D; Cell Line; Cross-Linking Reagents; Cyclopentanes; Enzyme Precursors; Glucosamine; Glycoside Hydrolases; Glycosylation; Humans; Molecular Weight; Protein Processing, Post-Translational | 1992 |
3-Hydroxy-3-methylglutaryl-coenzyme A reductase and T cell receptor alpha subunit are differentially degraded in the endoplasmic reticulum.
Topics: 1-Deoxynojirimycin; Acyl Coenzyme A; Animals; Brefeldin A; CHO Cells; Cricetinae; Cycloheximide; Cyclopentanes; Diamide; Endoplasmic Reticulum; Glucosamine; Plasmids; Protease Inhibitors; Receptors, Antigen, T-Cell, alpha-beta; Transfection | 1992 |
The spectrum of incomplete N-linked oligosaccharides synthesized by endothelial cells in the presence of brefeldin A.
Topics: Amidohydrolases; Animals; Brefeldin A; Carbohydrate Sequence; Cattle; Cells, Cultured; Chromatography, High Pressure Liquid; Chromatography, Ion Exchange; Cyclopentanes; Endoplasmic Reticulum; Endothelium, Vascular; Glycosylation; Hydrolysis; Molecular Sequence Data; Oligosaccharides; Peptide-N4-(N-acetyl-beta-glucosaminyl) Asparagine Amidase | 1992 |
Retrograde transport from the Golgi region to the endoplasmic reticulum is sensitive to GTP gamma S.
Topics: alpha 1-Antitrypsin; Bacterial Proteins; Biological Transport; Brefeldin A; Cell Membrane Permeability; Cyclopentanes; Endoplasmic Reticulum; Golgi Apparatus; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Microscopy, Electron; Sialic Acids; Sialyltransferases; Streptolysins; Tumor Cells, Cultured | 1992 |
Brefeldin A-induced increase of sphingomyelin synthesis. Assay for the action of the antibiotic in mammalian cells.
Topics: Animals; Anti-Bacterial Agents; Brefeldin A; Cell Line; CHO Cells; Choline; Colforsin; Cricetinae; Cyclopentanes; Golgi Apparatus; Kinetics; Radioisotope Dilution Technique; Sphingomyelins; Tritium | 1992 |
Action of brefeldin A blocked by activation of a pertussis-toxin-sensitive G protein.
Topics: Brefeldin A; Cell Compartmentation; Cell Membrane Permeability; Coatomer Protein; Cyclopentanes; Golgi Apparatus; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); In Vitro Techniques; Intercellular Signaling Peptides and Proteins; Intracellular Membranes; Microtubule-Associated Proteins; Peptides; Pertussis Toxin; Protein Binding; Virulence Factors, Bordetella; Wasp Venoms | 1992 |
Chloroquine inhibits intracellular degradation but not secretion of Alzheimer beta/A4 amyloid precursor protein.
Topics: Ammonium Chloride; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Anti-Bacterial Agents; Autoradiography; Brefeldin A; Chloroquine; Cyclopentanes; Glycosylation; Kinetics; Methionine; Molecular Weight; Monensin; Organelles; PC12 Cells; Protein Processing, Post-Translational; Sulfur Radioisotopes; Time Factors | 1992 |
Effects of brefeldin A on the synthesis of chondroitin 4-sulfate by cultures of mouse mastocytoma cells.
Topics: Animals; Brefeldin A; Chondroitin Sulfates; Cyclopentanes; Glucosamine; Mast-Cell Sarcoma; Mice; Mycotoxins; Sulfates; Tumor Cells, Cultured | 1992 |
Brefeldin A as a regulator of grp78 gene expression in mammalian cells.
Topics: Actins; Blotting, Northern; Brefeldin A; Carrier Proteins; Chloramphenicol O-Acetyltransferase; Cyclopentanes; DNA; Electrophoresis, Polyacrylamide Gel; Endoplasmic Reticulum Chaperone BiP; Gene Expression Regulation; Heat-Shock Proteins; Humans; Immunoglobulin Heavy Chains; Molecular Chaperones; Nucleic Acid Hybridization; Plasmids; Promoter Regions, Genetic; RNA Processing, Post-Transcriptional; RNA, Messenger; Transcription, Genetic; Tumor Cells, Cultured | 1992 |
Recruitment of coat proteins onto Golgi membranes in intact and permeabilized cells: effects of brefeldin A and G protein activators.
Topics: Adaptor Protein Complex alpha Subunits; Adaptor Protein Complex gamma Subunits; Adaptor Proteins, Vesicular Transport; Aluminum; Aluminum Compounds; Blotting, Western; Brefeldin A; Cell Line; Coatomer Protein; Cyclopentanes; Fluorides; Fluorine; Golgi Apparatus; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Microscopy, Fluorescence; Microtubule-Associated Proteins; Proteins | 1992 |
Maturation of lipoprotein lipase. Expression of full catalytic activity requires glucose trimming but not translocation to the cis-Golgi compartment.
Topics: Amino Acid Sequence; Animals; Anti-Bacterial Agents; Base Sequence; Blotting, Western; Brefeldin A; CHO Cells; Cloning, Molecular; Cricetinae; Cyclopentanes; Endoplasmic Reticulum; Genetic Vectors; Glycosylation; Golgi Apparatus; Humans; Kinetics; Lipoprotein Lipase; Models, Biological; Molecular Sequence Data; Mutagenesis; Protein Processing, Post-Translational; Restriction Mapping; Transfection | 1992 |
Identification of a 200-kD, brefeldin-sensitive protein on Golgi membranes.
Topics: Animals; Anti-Bacterial Agents; Antibodies, Monoclonal; Blotting, Western; Brefeldin A; Cell Line; Cyclopentanes; Dogs; Electrophoresis, Polyacrylamide Gel; Fluorescent Antibody Technique; Golgi Apparatus; Immunoenzyme Techniques; Intracellular Membranes; Liver; Membrane Proteins; Methionine; Microsomes; Molecular Weight; Phosphorylation; Rats; Trypsin | 1992 |
Brefeldin A binds to glutathione S-transferase and is secreted as glutathione and cysteine conjugates by Chinese hamster ovary cells.
Topics: Amino Acid Sequence; Animals; Anti-Bacterial Agents; Blotting, Western; Brain; Brefeldin A; Cattle; CHO Cells; Chromatography, High Pressure Liquid; Cricetinae; Cyclopentanes; Cysteine; Electrophoresis, Gel, Two-Dimensional; Electrophoresis, Polyacrylamide Gel; Glutathione; Glutathione Transferase; Molecular Sequence Data | 1992 |
Dissimilar effects of Brefeldin A on cholesteryl ester and triacylglycerol metabolism in CaCo2 and HepG2 cells as compared to peritoneal macrophages.
Topics: Acetylation; Brefeldin A; Cell Line; Cholesterol Esters; Cyclopentanes; Esterification; Humans; Kinetics; Macrophages; Oleic Acids; Peritoneum; Triglycerides | 1992 |
Effects of brefeldin A on the localization of chondroitin sulfate-synthesizing enzymes. Activities in subfractions of the Golgi from chick embryo epiphyseal cartilage.
Topics: Animals; Brefeldin A; Carbohydrate Sequence; Chick Embryo; Chondroitin Sulfates; Cyclopentanes; Galactosyltransferases; Golgi Apparatus; Growth Plate; Intracellular Membranes; Microsomes; Molecular Sequence Data | 1992 |
Retention of secretory proteins in an intermediate compartment and disappearance of the Golgi complex in an END4 mutant of Chinese hamster ovary cells.
Topics: Animals; Biological Transport; Brefeldin A; Cell Compartmentation; CHO Cells; Cricetinae; Cyclopentanes; Endoplasmic Reticulum; Glycoproteins; Glycosylation; Golgi Apparatus; Hemagglutinins, Viral; Hexosaminidases; Intracellular Membranes; Macromolecular Substances; Membrane Proteins; Microtubules; Monensin; Mutation; Protein Processing, Post-Translational; Proteins; Temperature; Time Factors | 1992 |
O-glycosylation of intact and truncated ribophorins in brefeldin A-treated cells: newly synthesized intact ribophorins are only transiently accessible to the relocated glycosyltransferases.
Topics: Brefeldin A; Cyclopentanes; Glycosylation; Glycosyltransferases; Golgi Apparatus; HeLa Cells; Humans; Membrane Proteins; Microscopy, Electron; Mycotoxins; Protein Processing, Post-Translational | 1992 |
The origin and fate of beta 2m-free MHC class I molecules induced on activated T cells.
Topics: beta 2-Microglobulin; Brefeldin A; Cell Membrane; Culture Media; Cyclopentanes; Histocompatibility Antigens Class I; Humans; Immunoglobulin Heavy Chains; Lymphocyte Activation; T-Lymphocytes; Tetradecanoylphorbol Acetate; Time Factors | 1992 |
Listeriolysin O is a target of the immune response to Listeria monocytogenes.
Topics: Animals; Anti-Bacterial Agents; Bacterial Toxins; Brefeldin A; Cell Line; Cells, Cultured; Cyclopentanes; Cytotoxicity, Immunologic; Female; Heat-Shock Proteins; Hemolysin Proteins; Immunization; Listeria monocytogenes; Listeriosis; Lymphocyte Depletion; Mice; Mice, Inbred BALB C; Spleen; T-Lymphocytes; T-Lymphocytes, Cytotoxic | 1992 |
Brefeldin A-resistant mutants of human epidermoid carcinoma cell line with structural changes of the Golgi apparatus.
Topics: Brefeldin A; Carcinoma, Squamous Cell; Cyclopentanes; Drug Resistance; Electrophoresis, Polyacrylamide Gel; Humans; Microscopy, Electron; Microscopy, Fluorescence; Monensin; Mutation; Precipitin Tests; Receptors, LDL; Tumor Cells, Cultured | 1992 |
Monensin and brefeldin A differentially affect the phosphorylation and sulfation of secretory proteins.
Topics: Animals; Autoradiography; Brefeldin A; Chromogranins; Cyclopentanes; Electrophoresis, Gel, Two-Dimensional; Endoplasmic Reticulum; Golgi Apparatus; Monensin; PC12 Cells; Phosphorylation; Protein Processing, Post-Translational; Proteins; Rats; Sulfuric Acids | 1992 |
100-kD proteins of Golgi- and trans-Golgi network-associated coated vesicles have related but distinct membrane binding properties.
Topics: Adaptor Protein Complex alpha Subunits; Adaptor Protein Complex gamma Subunits; Adaptor Proteins, Vesicular Transport; Animals; Brefeldin A; Cell Line; Coated Pits, Cell-Membrane; Coatomer Protein; Cyclopentanes; Cytoplasm; Fluorescent Antibody Technique; Golgi Apparatus; Intracellular Membranes; Microtubule-Associated Proteins; Protein Binding; Proteins | 1992 |
Stimulation of sphingomyelin biosynthesis by brefeldin A and sphingomyelin breakdown by okadaic acid treatment of rat hepatocytes.
Topics: Animals; Brefeldin A; Chloroquine; Colforsin; Cyclopentanes; Ethers, Cyclic; Kinetics; Liver; Male; Okadaic Acid; Phosphatidylcholines; Rats; Rats, Inbred Strains; Sphingomyelins | 1992 |
Brefeldin A enhances receptor-mediated transcytosis of transferrin in filter-grown Madin-Darby canine kidney cells.
Topics: Animals; Brefeldin A; Cells, Cultured; Cyclopentanes; Dogs; Endocytosis; Horseradish Peroxidase; Humans; Kidney; Polylysine; Receptors, Transferrin; Transferrin | 1992 |
Synthesis and secretion of proteins by released malarial parasites.
Topics: Adenosine Triphosphate; Animals; Anti-Bacterial Agents; Brefeldin A; Cyclopentanes; Cytosol; Erythrocytes; Hexokinase; Microscopy, Electron; Plasmodium falciparum; Protozoan Proteins; Ribonuclease, Pancreatic | 1992 |
Two distinct members of the ADP-ribosylation factor family of GTP-binding proteins regulate cell-free intra-Golgi transport.
Topics: ADP-Ribosylation Factor 1; ADP-Ribosylation Factors; Aluminum; Aluminum Compounds; Biological Transport; Brefeldin A; Cell-Free System; Cyclopentanes; Fluorides; Golgi Apparatus; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Viral Proteins | 1992 |
Characterization of a bile salt-dependent cholesteryl ester hydrolase activity secreted from HepG2 cells.
Topics: Animals; Bile Acids and Salts; Brefeldin A; Cyclopentanes; Humans; Liver; Male; Monensin; Perfusion; Rats; Rats, Inbred Strains; Sterol Esterase; Tumor Cells, Cultured | 1992 |
O-glycosylation of the coronavirus M protein. Differential localization of sialyltransferases in N- and O-linked glycosylation.
Topics: Animals; Antiviral Agents; Brefeldin A; Cell Line; Coronaviridae; Cyclopentanes; Fucose; Galactose; Glucosamine; Glycosylation; Golgi Apparatus; Kinetics; Methionine; N-Acetylneuraminic Acid; Neuraminidase; Oligosaccharides; Sialic Acids; Sialyltransferases; Sulfur Radioisotopes; Tritium; Viral Matrix Proteins | 1992 |
Post-Golgi membrane traffic: brefeldin A inhibits export from distal Golgi compartments to the cell surface but not recycling.
Topics: Animals; Anti-Bacterial Agents; Autoradiography; Brefeldin A; Cell Fractionation; Cell Line; Cell Membrane; Centrifugation, Density Gradient; Cricetinae; Cyclopentanes; Glycoproteins; Glycosaminoglycans; Golgi Apparatus; Kinetics; Membrane Glycoproteins; Sulfates; Sulfur Radioisotopes; Transferrin; Viral Envelope Proteins | 1992 |
Brefeldin A promotes hydrolysis of sphingomyelin.
Topics: Brefeldin A; Cell Differentiation; Cell Division; Cyclopentanes; Hydrolysis; Kinetics; Sphingomyelins; Temperature; Tumor Cells, Cultured | 1992 |
Oligomerization and post-translational processing of glycoprotein G of human respiratory syncytial virus: altered O-glycosylation in the presence of brefeldin A.
Topics: Antigens, Viral; Brefeldin A; Carbohydrate Sequence; Cyclopentanes; Endoplasmic Reticulum; Exocytosis; Glycoproteins; Glycosylation; Golgi Apparatus; HN Protein; Humans; Lectins; Molecular Sequence Data; N-Acetylneuraminic Acid; Oxidative Phosphorylation; Palmitic Acid; Palmitic Acids; Protein Conformation; Protein Processing, Post-Translational; Respiratory Syncytial Viruses; Sialic Acids; Viral Envelope Proteins; Viral Proteins | 1992 |
Modulation of sphingomyelinase-induced cholesterol esterification in fibroblasts, CaCo2 cells, macrophages and smooth muscle cells.
Topics: Brefeldin A; Cells, Cultured; Cholesterol; Cyclopentanes; Esterification; Fibroblasts; Humans; Macrophages; Muscle, Smooth, Vascular; Sphingomyelin Phosphodiesterase; Tumor Cells, Cultured; Verapamil | 1992 |
PDGF-AA and PDGF-BB biosynthesis: proprotein processing in the Golgi complex and lysosomal degradation of PDGF-BB retained intracellularly.
Topics: Animals; Brefeldin A; Chloroquine; CHO Cells; Cricetinae; Cyclopentanes; Electrophoresis, Polyacrylamide Gel; Fluorescent Antibody Technique; Golgi Apparatus; Lysosomes; Microscopy, Immunoelectron; Platelet-Derived Growth Factor; Protein Processing, Post-Translational; Transfection | 1992 |
Brefeldin A causes a microtubule-mediated fusion of the trans-Golgi network and early endosomes.
Topics: Animals; Brefeldin A; Cell Line; Cell Membrane; Cyclopentanes; Dogs; Endocytosis; Fluorescent Antibody Technique; Golgi Apparatus; Intracellular Membranes; Membrane Fusion; Microscopy, Electron; Microtubules; Mucolipidoses; Rats; Receptor, IGF Type 2; Receptors, Cell Surface | 1991 |
Effects of brefeldin A on the endocytic route. Redistribution of mannose 6-phosphate/insulin-like growth factor II receptors to the cell surface.
Topics: Affinity Labels; Animals; Antifungal Agents; Biological Transport; Brefeldin A; Cell Membrane; Cricetinae; Cross-Linking Reagents; Cyclopentanes; Endocytosis; Fibroblasts; Humans; Intracellular Membranes; Mannosephosphates; Methionine; Receptor, IGF Type 2; Receptors, Cell Surface; Receptors, Somatomedin; Somatomedins; Transferrin | 1991 |
Influenza virus hemagglutinin trimers and monomers maintain distinct biochemical modifications and intracellular distribution in brefeldin A-treated cells.
Topics: Animals; Brefeldin A; Cell Compartmentation; Cell Line; Cyclopentanes; Endoplasmic Reticulum; Exocytosis; Golgi Apparatus; Hemagglutinins, Viral; Microscopy, Fluorescence; Orthomyxoviridae; Phosphoric Monoester Hydrolases; Transferases | 1991 |
Class II MHC-restricted T cell determinants processed from either endosomes or the cytosol show similar requirements for host protein transport but different kinetics of presentation.
Topics: Animals; Antigen-Presenting Cells; Antigens, Viral; Biological Transport; Brefeldin A; Cyclopentanes; Cytosol; Drug Administration Schedule; Endosomes; Hemagglutinins, Viral; Histocompatibility Antigens Class II; Influenza A virus; Major Histocompatibility Complex; Mice; Neuraminidase; Peptide Fragments; T-Lymphocytes; Time Factors | 1991 |
Presentation of Leishmania donovani promastigotes occurs via a brefeldin A-sensitive pathway.
Topics: Animals; Antigen-Presenting Cells; Antigens, Protozoan; Brefeldin A; CD4-Positive T-Lymphocytes; Chloroquine; Cyclopentanes; Histocompatibility Antigens Class II; Leishmania donovani; Lymphocyte Activation; Lymphocyte Culture Test, Mixed; Macrophage Activation; Macrophages; Mice; Mice, Inbred Strains; Peritoneal Cavity | 1991 |
Brefeldin A's effects on endosomes, lysosomes, and the TGN suggest a general mechanism for regulating organelle structure and membrane traffic.
Topics: Animals; Biological Transport; Brefeldin A; Cell Line; Coatomer Protein; Cyclopentanes; Endocytosis; Endoplasmic Reticulum; Endosomes; Fluorescent Antibody Technique; Golgi Apparatus; In Vitro Techniques; Intracellular Membranes; Lysosomes; Membrane Proteins; Microscopy, Electron; Microtubule-Associated Proteins; Organelles; Rats; Receptors, Transferrin; Species Specificity; Transferrin | 1991 |
Quality control in the endoplasmic reticulum: folding and misfolding of vesicular stomatitis virus G protein in cells and in vitro.
Topics: Animals; Brefeldin A; Cell Line; Cell-Free System; Cyclopentanes; Disulfides; Endoplasmic Reticulum; Epitopes; In Vitro Techniques; Membrane Glycoproteins; Microsomes; Protein Conformation; Protein Processing, Post-Translational; Temperature; Vesicular stomatitis Indiana virus; Viral Envelope Proteins | 1990 |
PtK1 cells contain a nondiffusible, dominant factor that makes the Golgi apparatus resistant to brefeldin A.
Topics: Animals; Anti-Bacterial Agents; Brefeldin A; Cell Fusion; Cell Line; Cyclopentanes; Drug Resistance; Fluorescent Antibody Technique; Glycosylation; Golgi Apparatus; Kinetics; Macropodidae; Membrane Glycoproteins; Microscopy, Fluorescence; Oligosaccharides; Proteins; Staining and Labeling; Vesicular stomatitis Indiana virus; Viral Envelope Proteins | 1991 |
Formation of cation channels in planar lipid bilayers by brefeldin A.
Topics: Brefeldin A; Cations; Cyclopentanes; Electrochemistry; Ion Channels; Ionophores; Lipid Bilayers | 1991 |
Brefeldin A inhibits the processing and secretion of envelope glycoproteins of human immunodeficiency virus type 1.
Topics: Antiviral Agents; Brefeldin A; Carbohydrate Sequence; Cell Fractionation; Cell Line; Cyclopentanes; Gene Products, env; HIV Envelope Protein gp160; HIV Reverse Transcriptase; HIV Seropositivity; HIV-1; Humans; Macrophages; Molecular Sequence Data; Precipitin Tests; Protein Precursors; Protein Processing, Post-Translational; RNA-Directed DNA Polymerase | 1991 |
Mitosis and inhibition of intracellular transport stimulate palmitoylation of a 62-kD protein.
Topics: Acylation; Aluminum; Aluminum Compounds; Animals; Anti-Bacterial Agents; Brefeldin A; Carbonyl Cyanide m-Chlorophenyl Hydrazone; Cell Fractionation; Centrifugation, Density Gradient; CHO Cells; Clone Cells; Cricetinae; Cyclopentanes; Fluorides; Fluorine; Interphase; Microsomes; Mitosis; Mitotic Index; Molecular Weight; Monensin; Nocodazole; Organelles; Palmitic Acid; Palmitic Acids; Proteins; Subcellular Fractions | 1992 |
Assembly and disassembly of the Golgi complex: two processes arranged in a cis-trans direction.
Topics: Animals; Anti-Bacterial Agents; Brefeldin A; Cells, Cultured; Cyclopentanes; Endoplasmic Reticulum; Ethylmaleimide; Golgi Apparatus; Kidney; Membrane Proteins; Microtubules; Rats; Temperature | 1992 |
Perturbation of the morphology of the trans-Golgi network following Brefeldin A treatment: redistribution of a TGN-specific integral membrane protein, TGN38.
Topics: Animals; Anti-Bacterial Agents; Brefeldin A; Cells, Cultured; Cyclopentanes; Fluorescent Antibody Technique; Glycoproteins; Golgi Apparatus; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Triphosphate; Kidney; Membrane Glycoproteins; Membrane Proteins; Nocodazole; Rats | 1992 |
Translocation of oxysterol binding protein to Golgi apparatus triggered by ligand binding.
Topics: Animals; Base Sequence; Biological Transport; Brefeldin A; CHO Cells; Cricetinae; Cross-Linking Reagents; Cyclopentanes; DNA Mutational Analysis; Fluorescent Antibody Technique; Glutaral; Golgi Apparatus; Hydroxycholesterols; In Vitro Techniques; Leucine Zippers; Molecular Sequence Data; Receptors, Steroid; Recombinant Proteins; Structure-Activity Relationship | 1992 |
Hepatitis B virus (HBV)-specific cytotoxic T-cell (CTL) response in humans: characterization of HLA class II-restricted CTLs that recognize endogenously synthesized HBV envelope antigens.
Topics: Ammonium Chloride; Antigens, Viral; Antiviral Agents; Brefeldin A; CD4 Antigens; Chloroquine; Clone Cells; Cyclopentanes; Hepatitis B; Hepatitis B virus; HLA-D Antigens; Humans; Recombination, Genetic; T-Lymphocytes, Cytotoxic; Vaccinia virus; Viral Envelope Proteins | 1992 |
Post-translational processing and oligomerization of the fusion glycoprotein of human respiratory syncytial virus.
Topics: Antigens, Viral; Brefeldin A; Carbonyl Cyanide m-Chlorophenyl Hydrazone; Cross-Linking Reagents; Cyclopentanes; Electrophoresis, Polyacrylamide Gel; Endoplasmic Reticulum; Exocytosis; Glycosylation; Golgi Apparatus; HN Protein; Kinetics; Monensin; Polymers; Precipitin Tests; Protein Processing, Post-Translational; Respiratory Syncytial Viruses; Viral Envelope Proteins; Viral Fusion Proteins; Viral Proteins | 1991 |
Evidence that differentiates between precursor cleavages at dibasic and Arg-X-Lys/Arg-Arg sites.
Topics: alpha 1-Antitrypsin; Amino Acid Sequence; Animals; Antifungal Agents; Arginine; Binding Sites; Brefeldin A; Calcium; CHO Cells; Colchicine; Cricetinae; Cricetulus; Cyclopentanes; Enzyme Precursors; Hydrolysis; Intracellular Fluid; Lysine; Mice; Molecular Sequence Data; Mutation; Pituitary Gland; Protein Precursors; Renin | 1991 |
Glycoprotein expression in mouse cerebellum: effects of inhibitors of vesicle function.
Topics: Ammonia; Animals; Brefeldin A; Carbonyl Cyanide m-Chlorophenyl Hydrazone; Cerebellum; Cyclopentanes; Diethylcarbamazine; Embryo, Mammalian; Gene Expression; Glycoproteins; Glycoside Hydrolases; Golgi Apparatus; Mice; Monensin; Organ Culture Techniques | 1991 |
Disruption of the Golgi apparatus with brefeldin A does not destabilize the associated detyrosinated microtubule network.
Topics: Animals; Antibodies; Blotting, Western; Brefeldin A; Cyclopentanes; Golgi Apparatus; Lectins; Microscopy, Fluorescence; Microtubules; Rats; Tumor Cells, Cultured; Tyrosine; Wheat Germ Agglutinins | 1991 |
Processing to endoglycosidase H-resistant thyrotropin subunits occurs in the presence of brefeldin-A: evidence favoring the recycling of Golgi membranes to the rough endoplasmic reticulum in mouse thyrotrophs.
Topics: Adenosine Triphosphate; Animals; Anti-Bacterial Agents; Brefeldin A; Carbonyl Cyanide m-Chlorophenyl Hydrazone; Cyclopentanes; Endoplasmic Reticulum; Golgi Apparatus; Hexosaminidases; Intracellular Membranes; Mannosyl-Glycoprotein Endo-beta-N-Acetylglucosaminidase; Methionine; Mice; Mice, Inbred ICR; Pituitary Gland; RNA Processing, Post-Transcriptional; Sulfur Radioisotopes; Swainsonine; Thyroid Gland; Thyroid Neoplasms; Thyrotropin | 1991 |
Depletion of cellular calcium accelerates protein degradation in the endoplasmic reticulum.
Topics: Animals; Antigens, Differentiation, T-Lymphocyte; Brefeldin A; Calcimycin; Calcium; Calcium-Transporting ATPases; CD3 Complex; Cell Line; Chloroquine; Cricetinae; Cyclopentanes; Dose-Response Relationship, Drug; Endoplasmic Reticulum; Humans; In Vitro Techniques; Lysosomes; Protein Processing, Post-Translational; Receptors, Antigen, T-Cell; Receptors, Antigen, T-Cell, alpha-beta; Receptors, Interleukin-2; Secretory Rate; Terpenes; Thapsigargin; Transfection | 1991 |
Inhibition of atrial peptide secretion at different stages of the secretory process: Ca2+ dependence.
Topics: Animals; Atrial Natriuretic Factor; Brefeldin A; Calcium; Cyclopentanes; Endoplasmic Reticulum; Female; Golgi Apparatus; Heart Atria; Kinetics; Microscopy, Electron; Protein Synthesis Inhibitors; Rats; Rats, Inbred Strains | 1991 |
Forskolin inhibits and reverses the effects of brefeldin A on Golgi morphology by a cAMP-independent mechanism.
Topics: 4-Chloro-7-nitrobenzofurazan; Animals; Brefeldin A; Cells, Cultured; Ceramides; Colforsin; Cyclic AMP; Cyclopentanes; Fluorescent Dyes; Golgi Apparatus; Intracellular Membranes; Mannosidases; Molecular Structure; Oligosaccharides | 1991 |
Effect of brefeldin A on alphaherpesvirus membrane protein glycosylation and virus egress.
Topics: Animals; Antiviral Agents; Brefeldin A; Capsid; Cell Line; Cell Transformation, Viral; Cyclopentanes; Glycosylation; Golgi Apparatus; Herpesvirus 1, Suid; Kinetics; Membrane Glycoproteins; Microscopy, Electron; Models, Biological; Nuclear Envelope; Swine; Virion; Virus Replication | 1991 |
Assembly and polarized release of Punta Toro virus and effects of brefeldin A.
Topics: Animals; Antiviral Agents; Brefeldin A; Cyclopentanes; Egtazic Acid; Fluorescent Antibody Technique; Kinetics; Microscopy, Electron; Phlebovirus; Recombination, Genetic; Vaccinia virus; Vero Cells; Viral Plaque Assay; Viral Proteins; Virus Replication | 1991 |
Brefeldin A arrests the maturation and egress of herpes simplex virus particles during infection.
Topics: Animals; Antiviral Agents; Biological Transport; Brefeldin A; Capsid; Cells, Cultured; Cyclopentanes; Drug Resistance, Microbial; Endoplasmic Reticulum; Golgi Apparatus; Herpes Simplex; Sensitivity and Specificity; Simplexvirus; Viral Core Proteins; Viral Envelope Proteins; Virion; Virus Replication | 1991 |
Dissociation and reassociation of oligomeric viral glycoprotein subunits in the endoplasmic reticulum.
Topics: Animals; Antiviral Agents; Base Sequence; Biological Transport; Brefeldin A; Cells, Cultured; Chemical Precipitation; Cricetinae; Cyclopentanes; Endoplasmic Reticulum; Kinetics; Membrane Glycoproteins; Molecular Sequence Data; Mutagenesis; Vesicular stomatitis Indiana virus; Viral Envelope Proteins | 1991 |
Effects of brefeldin A on the processing of viral envelope glycoproteins in murine erythroleukemia cells.
Topics: Animals; Biological Transport; Brefeldin A; Cell Compartmentation; Cyclopentanes; Endoplasmic Reticulum; Gene Products, env; Glycosylation; Golgi Apparatus; In Vitro Techniques; Leukemia Virus, Murine; Leukemia, Erythroblastic, Acute; Mice; Molecular Weight; Protein Processing, Post-Translational; Spleen Focus-Forming Viruses; Tumor Cells, Cultured; Viral Envelope Proteins | 1991 |
Proteolytic conversion of hepatitis B virus e antigen precursor to end product occurs in a postendoplasmic reticulum compartment.
Topics: Biological Transport; Brefeldin A; Cell Compartmentation; Cyclopentanes; Endoplasmic Reticulum; Golgi Apparatus; Hepatitis B; Hepatitis B e Antigens; Molecular Weight; Protein Precursors; Protein Processing, Post-Translational; Subcellular Fractions; Tumor Cells, Cultured; Viral Core Proteins | 1991 |
Entry of diphtheria toxin-protein A chimeras into cells.
Topics: Animals; Base Sequence; Biological Transport; Brefeldin A; Cycloheximide; Cyclopentanes; Deoxyribonucleotides; Diphtheria Toxin; Down-Regulation; Endocytosis; HeLa Cells; Heparin-binding EGF-like Growth Factor; Humans; Intercellular Signaling Peptides and Proteins; Kinetics; L Cells; Mice; Molecular Sequence Data; Monensin; Receptors, Cell Surface; Receptors, Cholinergic; Recombinant Fusion Proteins; Staphylococcal Protein A; Temperature; Vero Cells | 1991 |
Disruption of the Golgi apparatus by brefeldin A inhibits the cytotoxicity of ricin, modeccin, and Pseudomonas toxin.
Topics: ADP Ribose Transferases; Alkaloids; Ammonium Chloride; Animals; Bacterial Toxins; Brefeldin A; Cell Line; Cyclopentanes; Cytotoxins; Endocytosis; Exotoxins; Golgi Apparatus; Kinetics; Lectins; Mutation; Plant Lectins; Pseudomonas aeruginosa Exotoxin A; Ribosome Inactivating Proteins, Type 2; Ricin; Swainsonine; Tunicamycin; Virulence Factors | 1991 |
Brefeldin A induces endoplasmic reticulum-associated O-glycosylation of galactosyltransferase.
Topics: Acetylglucosaminidase; Brefeldin A; Cyclopentanes; Endoplasmic Reticulum; Fluorescent Antibody Technique; Galactosyltransferases; Glycoproteins; Glycosylation; HeLa Cells; Hexosaminidases; Humans; In Vitro Techniques; Mannosyl-Glycoprotein Endo-beta-N-Acetylglucosaminidase; Molecular Weight; Protein Processing, Post-Translational | 1991 |
Guanosine nucleotides modulate the inhibitory effect of brefeldin A on protein secretion.
Topics: Animals; Brefeldin A; Cells, Cultured; Cholecystokinin; Cyclopentanes; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Triphosphate; Kinetics; Male; Pancreas; Protein Biosynthesis; Proteins; Rats; Rats, Inbred Strains | 1991 |
Increased cytotoxic activity of Pseudomonas exotoxin and two chimeric toxins ending in KDEL.
Topics: ADP Ribose Transferases; Amino Acid Sequence; Animals; Bacterial Toxins; Brefeldin A; Cell Line; Chimera; Cloning, Molecular; Cyclopentanes; Electrophoresis, Polyacrylamide Gel; Exotoxins; Female; Mice; Mice, Inbred BALB C; Molecular Sequence Data; Protein Synthesis Inhibitors; Pseudomonas aeruginosa; Pseudomonas aeruginosa Exotoxin A; Virulence Factors | 1991 |
Brefeldin A induces a microtubule-dependent fusion of galactosyltransferase-containing vesicles with the rough endoplasmic reticulum.
Topics: Antifungal Agents; Brefeldin A; Cyclopentanes; Endoplasmic Reticulum; Fluorescent Antibody Technique; Galactosyltransferases; Golgi Apparatus; HeLa Cells; Humans; Microscopy, Immunoelectron; Microtubules | 1991 |
Inhibition by brefeldin A of protein secretion from the apical cell surface of Madin-Darby canine kidney cells.
Topics: 4-Chloro-7-nitrobenzofurazan; Animals; Biological Transport; Brefeldin A; Cell Line; Ceramides; Cyclopentanes; Dogs; Electrophoresis, Polyacrylamide Gel; Fluorescent Dyes; Golgi Apparatus; Kidney; Proteins | 1991 |
Brefeldin-A enhancement of ricin A-chain immunotoxins and blockade of intact ricin, modeccin, and abrin.
Topics: Abrin; Antitoxins; Biological Transport; Brefeldin A; Cyclopentanes; Drug Interactions; Golgi Apparatus; Humans; Immunotoxins; Interleukin-2; Kinetics; Lectins; Lymphoma; Plant Lectins; Ribosome Inactivating Proteins, Type 2; Ricin; Toxins, Biological; Tumor Cells, Cultured | 1991 |
Distinct intracellular fates of membrane and secretory immunoglobulin heavy chains in a pre-B cell line.
Topics: Ammonium Chloride; Animals; B-Lymphocytes; Brefeldin A; Cell Line, Transformed; Chloroquine; Cyclopentanes; Immunoglobulin A, Secretory; Immunoglobulin Heavy Chains; Immunoglobulin Isotypes; Kinetics; Lysosomes; Monensin; Receptors, Antigen, B-Cell | 1991 |
Rapid intracellular pathway gives rise to cell surface expression of the MHC class II-associated invariant chain (CD74).
Topics: Antigens, Differentiation, B-Lymphocyte; Antigens, Surface; Biological Transport; Brefeldin A; Chloroquine; Cyclopentanes; Histocompatibility Antigens Class II; Humans; Lymphoma, B-Cell; Microscopy, Immunoelectron; Tumor Cells, Cultured | 1991 |
Brefeldin A blocks an early stage of protein transport in Candida albicans.
Topics: Acid Phosphatase; Antifungal Agents; Biological Transport; Brefeldin A; Candida albicans; Cyclopentanes; Endoplasmic Reticulum; Fungal Proteins; Glycosylation; Golgi Apparatus; Intracellular Membranes; Microscopy, Electron | 1991 |
Effects of brefeldin A on oligosaccharide processing. Evidence for decreased branching of complex-type glycans and increased formation of hybrid-type glycans.
Topics: Animals; Brefeldin A; Cell Line; Chromatography, Liquid; Chromatography, Paper; Cricetinae; Cyclopentanes; Glycopeptides; Hexosaminidases; Mannosyl-Glycoprotein Endo-beta-N-Acetylglucosaminidase; Oligosaccharides; Polysaccharides | 1991 |
Selective inhibition of transcytosis by brefeldin A in MDCK cells.
Topics: Animals; Biological Transport; Brefeldin A; Cattle; Cell Line; Cell Membrane; Cell Polarity; Cyclopentanes; Endocytosis; Epithelium; Fluorescent Antibody Technique; Golgi Apparatus; Immunoglobulin A; In Vitro Techniques; Intracellular Membranes; Membrane Glycoproteins; Microscopy, Electron; Microtubules; Receptors, Fc; Receptors, Immunologic; Secretory Component; Transferrin | 1991 |
The membrane spanning domain of beta-1,4-galactosyltransferase specifies trans Golgi localization.
Topics: Amino Acid Sequence; Antigens, Differentiation, B-Lymphocyte; Brefeldin A; Cell Membrane; Cyclopentanes; Cytoplasm; DNA; Electrophoresis, Polyacrylamide Gel; Flow Cytometry; Golgi Apparatus; HeLa Cells; Histocompatibility Antigens Class II; Humans; Microscopy, Electron; Microscopy, Fluorescence; Molecular Sequence Data; N-Acetyllactosamine Synthase; Transfection | 1991 |
Inhibition by brefeldin A of the specific B cell antigen presentation to MHC class II-restricted T cells.
Topics: Animals; Antigen-Presenting Cells; B-Lymphocytes; Biological Transport; Brefeldin A; Cyclopentanes; Dose-Response Relationship, Drug; Dose-Response Relationship, Immunologic; Endoplasmic Reticulum; Histocompatibility Antigens Class II; In Vitro Techniques; Interleukin-2; Lymphocyte Activation; Mice; Ovalbumin; Trinitrobenzenes | 1991 |
DS28-6, a temperature-sensitive mutant of Chinese hamster ovary cells, expresses key phenotypic changes associated with brefeldin A treatment.
Topics: Animals; Biological Transport; Brefeldin A; CHO Cells; Cricetinae; Cyclopentanes; Endoplasmic Reticulum; Fluorescent Antibody Technique; Galactosyltransferases; Glycosylation; Golgi Apparatus; Intracellular Membranes; Microscopy, Electron; Mutation; Phenotype; Protein Processing, Post-Translational; Proteins; Temperature | 1991 |
Ricin transport in brefeldin A-treated cells: correlation between Golgi structure and toxic effect.
Topics: Animals; Biological Transport; Brefeldin A; Cell Fractionation; Cell Line; Cyclopentanes; Golgi Apparatus; Humans; Microscopy, Electron; Ricin; Tumor Cells, Cultured | 1991 |
Uncoupling of chondroitin sulfate glycosaminoglycan synthesis by brefeldin A.
Topics: Antigens, Neoplasm; Biological Transport; Brefeldin A; Chondroitin Sulfates; Chromatography, High Pressure Liquid; Cyclopentanes; Glycosaminoglycans; Glycosides; Humans; Proteoglycans | 1991 |
Binding of ARF and beta-COP to Golgi membranes: possible regulation by a trimeric G protein.
Topics: ADP-Ribosylation Factors; Aluminum; Aluminum Compounds; Animals; Biological Transport; Brefeldin A; CHO Cells; Coatomer Protein; Cricetinae; Cyclopentanes; Endoplasmic Reticulum; Fluorides; Golgi Apparatus; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); In Vitro Techniques; Intracellular Membranes; Microtubule-Associated Proteins | 1991 |
Class II MHC molecules can use the endogenous pathway of antigen presentation.
Topics: Antigen-Presenting Cells; Biological Transport; Brefeldin A; CD4-Positive T-Lymphocytes; Chloroquine; Cyclopentanes; Cytoplasm; Histocompatibility Antigens Class I; HLA-D Antigens; Humans; Immunity, Cellular; In Vitro Techniques; Influenza A virus; Major Histocompatibility Complex; T-Lymphocytes, Cytotoxic; Viral Matrix Proteins | 1990 |
Guanine nucleotides modulate the effects of brefeldin A in semipermeable cells: regulation of the association of a 110-kD peripheral membrane protein with the Golgi apparatus.
Topics: Adenosine Triphosphate; Aluminum; Aluminum Compounds; Animals; Brefeldin A; Cell Membrane Permeability; Cells, Cultured; Cyclopentanes; Cytosol; Fluorides; Fluorine; Golgi Apparatus; Guanine Nucleotides; Guanosine 5'-O-(3-Thiotriphosphate); Membrane Proteins; Molecular Weight | 1991 |
Brefeldin A, a drug that blocks secretion, prevents the assembly of non-clathrin-coated buds on Golgi cisternae.
Topics: Animals; Biological Transport; Brefeldin A; Cell-Free System; Cells, Cultured; Cyclopentanes; Cytosol; Golgi Apparatus | 1991 |
Brefeldin A does not inhibit the movement of phosphatidylethanolamine from its sites for synthesis to the cell surface.
Topics: Animals; Biological Transport; Brefeldin A; Cell Membrane; Cells, Cultured; Cyclopentanes; Female; Kinetics; Liver; Mitochondria, Liver; Phosphatidylethanolamines; Rats; Rats, Inbred Strains | 1991 |
Effects of Brefeldin A on the Golgi complex, endoplasmic reticulum and viral envelope glycoproteins in murine erythroleukemia cells.
Topics: Animals; Antiviral Agents; Brefeldin A; Cyclopentanes; Endoplasmic Reticulum; Golgi Apparatus; Leukemia, Erythroblastic, Acute; Mice; Microscopy, Electron; Retroviridae; Tumor Cells, Cultured; Viral Envelope Proteins | 1991 |
Antigen presentation of hen egg-white lysozyme but not of ribonuclease A is augmented by the major histocompatibility complex class II-associated invariant chain.
Topics: Animals; Antigen-Presenting Cells; Antigens, Differentiation, B-Lymphocyte; Brefeldin A; Cyclopentanes; Egg Proteins; Histocompatibility Antigens Class II; Muramidase; Rats; Ribonuclease, Pancreatic; Transfection | 1991 |
Dilated rough endoplasmic reticulum and premature death in melanocytes cultured from the vitiligo mouse.
Topics: Animals; Brefeldin A; Cell Survival; Cells, Cultured; Cycloheximide; Cyclopentanes; Endoplasmic Reticulum; Melanocytes; Mice; Mice, Inbred C57BL; Mice, Mutant Strains; Microscopy, Electron; Time Factors; Vitiligo | 1991 |
Brefeldin A arrests the intracellular transport of viral envelope proteins in primary cultured rat hepatocytes and HepG2 cells.
Topics: Animals; Biological Transport; Blood Proteins; Brefeldin A; Cells, Cultured; Cyclopentanes; Electrophoresis, Polyacrylamide Gel; GTP-Binding Proteins; Hexosaminidases; Liver; Liver Neoplasms, Experimental; Male; Neuraminidase; Precipitin Tests; Rats; Rats, Inbred Strains; Tumor Cells, Cultured; Viral Envelope Proteins | 1990 |
Proteolytic processing of the 600 kd low density lipoprotein receptor-related protein (LRP) occurs in a trans-Golgi compartment.
Topics: Acetylglucosaminidase; Amino Acid Sequence; Animals; Antibodies, Monoclonal; Brefeldin A; Cells, Cultured; Cyclopentanes; Fluorescent Antibody Technique; Glycoside Hydrolases; Golgi Apparatus; Humans; Liver; Low Density Lipoprotein Receptor-Related Protein-1; Mannosyl-Glycoprotein Endo-beta-N-Acetylglucosaminidase; Mice; Molecular Sequence Data; Molecular Weight; Neuraminidase; Protein Conformation; Rabbits; Rats; Receptors, Immunologic | 1990 |
Degradation of newly synthesized apolipoprotein B-100 in a pre-Golgi compartment.
Topics: alpha 1-Antitrypsin; Anti-Bacterial Agents; Apolipoprotein A-I; Apolipoprotein B-100; Apolipoproteins A; Apolipoproteins B; Brefeldin A; Cell Line; Cyclopentanes; Golgi Apparatus; Humans; Kinetics; Lipoproteins, HDL; Lipoproteins, LDL; Methionine; Sulfur Radioisotopes; Tumor Cells, Cultured | 1990 |
Increased cytotoxicity of ricin in a putative Golgi-defective mutant of Chinese hamster ovary cell.
Topics: Alkaloids; Ammonium Chloride; Animals; Anti-Bacterial Agents; Brefeldin A; Cell Line; Cyclopentanes; Diphtheria Toxin; Glycosylation; Golgi Apparatus; Lectins; Macrolides; Mutation; Nigericin; Plant Lectins; Protein Biosynthesis; Ribosome Inactivating Proteins, Type 2; Ricin; Swainsonine; Toxins, Biological | 1990 |
Cytotoxic T cell recognition of an endogenous class I HLA peptide presented by a class II HLA molecule.
Topics: Anti-Bacterial Agents; Antigens, CD; Antigens, Differentiation, T-Lymphocyte; Brefeldin A; CD4 Antigens; CD8 Antigens; Cell Line; Chloroquine; Cyclopentanes; Cytotoxicity, Immunologic; Histocompatibility Antigens Class I; Histocompatibility Antigens Class II; Humans; Leukocytes; Peptide Fragments; T-Lymphocytes, Cytotoxic | 1990 |
Use of brefeldin A to define sites of glycosphingolipid synthesis: GA2/GM2/GD2 synthase is trans to the brefeldin A block.
Topics: Animals; Anti-Bacterial Agents; Brefeldin A; Carbohydrate Conformation; Carbohydrate Sequence; Cell Line; Cyclopentanes; Endoplasmic Reticulum; Galactosyltransferases; Glycosphingolipids; Golgi Apparatus; Humans; Melanoma; Molecular Sequence Data; N-Acetylgalactosaminyltransferases; Polypeptide N-acetylgalactosaminyltransferase | 1990 |
Detoxification of the macrolide toxin brefeldin A by Bacillus subtilis.
Topics: Bacillus subtilis; Brefeldin A; Cyclopentanes; Drug Resistance, Microbial; Hydrolysis; Lactones; Magnetic Resonance Spectroscopy | 1990 |
Antigen presentation requires transport of MHC class I molecules from the endoplasmic reticulum.
Topics: Adenovirus Early Proteins; Animals; Antigen-Presenting Cells; Antigens; Antigens, Viral; Antiviral Agents; Biological Transport; Brefeldin A; Cell Line; Cyclopentanes; Endoplasmic Reticulum; Exocytosis; Glycoproteins; H-2 Antigens; Histocompatibility Antigens Class I; Mice; Mice, Inbred A; Mice, Inbred BALB C; Mice, Inbred C3H; Mice, Inbred CBA; Oncogene Proteins, Viral; Orthomyxoviridae Infections; Recombinant Proteins; T-Lymphocytes, Cytotoxic; Vaccinia virus | 1990 |
Cholesterol and vesicular stomatitis virus G protein take separate routes from the endoplasmic reticulum to the plasma membrane.
Topics: Animals; Antiviral Agents; Biological Transport; Brefeldin A; Cell Fractionation; Cell Line; Cell Membrane; Cholesterol; Cyclopentanes; Endoplasmic Reticulum; Kinetics; Membrane Glycoproteins; Methionine; Models, Biological; Vesicular stomatitis Indiana virus; Viral Envelope Proteins | 1990 |
Identification by anti-idiotype antibodies of an intracellular membrane protein that recognizes a mammalian endoplasmic reticulum retention signal.
Topics: Amino Acid Sequence; Animals; Antibodies, Anti-Idiotypic; Antibodies, Monoclonal; Brefeldin A; Cell Compartmentation; Cyclopentanes; Endoplasmic Reticulum; Fluorescent Antibody Technique; Hybridomas; Membrane Proteins; Mice; Molecular Sequence Data; Molecular Weight; Oligopeptides; Proteins; Receptors, Cell Surface; Receptors, Peptide; Solubility | 1990 |
Inhibitory effect of herpes simplex virus infection to target cells on recognition of minor histocompatibility antigens by cytotoxic T lymphocytes.
Topics: Animals; Antibodies, Viral; Antigens, Viral; Brefeldin A; Cell Compartmentation; Cyclopentanes; Cytotoxicity, Immunologic; H-2 Antigens; Herpes Simplex; Histocompatibility Antigens; Immunity, Cellular; Mice; Mice, Inbred Strains; Minor Histocompatibility Loci; Precipitin Tests; Simplexvirus; T-Lymphocytes, Cytotoxic | 1990 |
Compartmentation of the Golgi complex: brefeldin-A distinguishes trans-Golgi cisternae from the trans-Golgi network.
Topics: Animals; beta-D-Galactoside alpha 2-6-Sialyltransferase; Brefeldin A; Cell Compartmentation; Cell Line; Cyclopentanes; Endoplasmic Reticulum; Galactosyltransferases; Golgi Apparatus; Receptor, IGF Type 2; Receptors, Cell Surface; Sialyltransferases | 1990 |
Microtubule-dependent retrograde transport of proteins into the ER in the presence of brefeldin A suggests an ER recycling pathway.
Topics: Animals; Anti-Bacterial Agents; Brefeldin A; Cell Line; Cyclopentanes; Endoplasmic Reticulum; Fluorescent Antibody Technique; Golgi Apparatus; Humans; Immunoenzyme Techniques; Microscopy, Electron; Microtubules; Proteins | 1990 |
Differential effects of brefeldin A on sialylation of N- and O-linked oligosaccharides in low density lipoprotein receptor and epidermal growth factor receptor.
Topics: Animals; Anti-Bacterial Agents; Brefeldin A; Cell Line; Cyclopentanes; ErbB Receptors; Humans; Kinetics; Oligosaccharides; Protein Processing, Post-Translational; Receptors, LDL; Sialyltransferases; Tunicamycin | 1990 |
Covalent oligomerization of rat gastric mucin occurs in the rough endoplasmic reticulum, is N-glycosylation-dependent, and precedes initial O-glycosylation.
Topics: Animals; Biological Transport; Brefeldin A; Carbonyl Cyanide m-Chlorophenyl Hydrazone; Cyclopentanes; Disulfides; Endoplasmic Reticulum; Gastric Mucosa; Glycosylation; Golgi Apparatus; In Vitro Techniques; Macromolecular Substances; Molecular Weight; Monensin; Mucins; Protein Precursors; Protein Processing, Post-Translational; Rats; Structure-Activity Relationship; Sulfates; Temperature | 1990 |
Brefeldin A prevents uncovering but not phosphorylation of the recognition marker in cathepsin D.
Topics: Biological Transport; Biomarkers; Brefeldin A; Cathepsin D; Cells, Cultured; Cyclopentanes; Humans; Hydrolysis; Mannosephosphates; Phosphorylation; Subcellular Fractions | 1990 |
The regulated degradation of 3-hydroxy-3-methylglutaryl-CoA reductase requires a short-lived protein and occurs in the endoplasmic reticulum.
Topics: Animals; Brefeldin A; Cell Line; Cricetinae; Cricetulus; Cycloheximide; Cyclopentanes; Endoplasmic Reticulum; Female; Hydroxymethylglutaryl CoA Reductases; Intracellular Membranes; Lovastatin; Mevalonic Acid; Ovary; Proteins; Recombinant Fusion Proteins; Transfection | 1990 |
Intracellular accumulation and oligosaccharide processing of alkaline phosphatase under disassembly of the Golgi complex caused by brefeldin A.
Topics: Alkaline Phosphatase; Brefeldin A; Choriocarcinoma; Cyclopentanes; Electrophoresis, Polyacrylamide Gel; Endoplasmic Reticulum; Glycosylation; Golgi Apparatus; Humans; Isoelectric Focusing; Microscopy, Electron; Oligosaccharides; Precipitin Tests; Tumor Cells, Cultured | 1990 |
Dissociation of a 110-kD peripheral membrane protein from the Golgi apparatus is an early event in brefeldin A action.
Topics: Adenosine Triphosphate; Animals; Anti-Bacterial Agents; Antibodies, Monoclonal; Brefeldin A; Cell Line; Cyclopentanes; Endoplasmic Reticulum; Fluorescent Antibody Technique; Golgi Apparatus; Intracellular Membranes; Kinetics; Membrane Proteins; Molecular Weight | 1990 |
Membranes. Violating the one-way system.
Topics: Antifungal Agents; Biological Transport; Brefeldin A; Cyclopentanes; Endoplasmic Reticulum; Golgi Apparatus; Intracellular Membranes; Microtubules; Proteins | 1990 |
A novel secretory pathway for interleukin-1 beta, a protein lacking a signal sequence.
Topics: Brefeldin A; Cyclopentanes; Hot Temperature; Humans; Interleukin-1; Kinetics; Lipopolysaccharides; Methylamines; Monensin; Monocytes; Protein Processing, Post-Translational; Subcellular Fractions | 1990 |
Uncoupling of ganglioside biosynthesis by Brefeldin A.
Topics: Animals; Brefeldin A; Cells, Cultured; Cerebellum; Cyclopentanes; Galactose; Glycosphingolipids; Glycosylation; Mice; Neurons; Sphingomyelins; Sphingosine | 1990 |
Morphological effects of brefeldin A on the intracellular transport of secretory materials in parotid acinar cells.
Topics: Animals; Biological Transport; Brefeldin A; Cyclopentanes; Histocytochemistry; In Vitro Techniques; Isoproterenol; Male; Parotid Gland; Proteins; Rats; Rats, Inbred Strains | 1990 |
Inhibition by brefeldin A of presentation of exogenous protein antigens to MHC class II-restricted T cells.
Topics: Animals; Antigen-Presenting Cells; Antigens; Brefeldin A; Cell Compartmentation; Cell Line; Cyclopentanes; Histocompatibility Antigens Class II; In Vitro Techniques; Mice; Muramidase; Ovalbumin; Peptides; Solubility; T-Lymphocytes | 1990 |
MHC class II-restricted presentation of native protein antigen by B cells is inhibitable by cycloheximide and brefeldin A.
Topics: Animals; Antigen-Presenting Cells; B-Lymphocytes; Brefeldin A; Cycloheximide; Cyclopentanes; Histocompatibility Antigens Class II; Interleukin-2; Mice; Mice, Inbred BALB C; Protein Synthesis Inhibitors; Tumor Cells, Cultured | 1990 |
Rapid turnover of low-density lipoprotein receptor by a non-lysosomal pathway in mouse macrophage J774 cells and inhibitory effect of brefeldin A.
Topics: Animals; Brefeldin A; Cell Line; Cell Membrane; Cyclopentanes; Endoplasmic Reticulum; Golgi Apparatus; L Cells; Lysosomes; Macrophages; Mice; Microscopy, Electron; Protease Inhibitors; Receptors, LDL | 1990 |
An endogenous processing pathway in vaccinia virus-infected cells for presentation of cytoplasmic antigens to class II-restricted T cells.
Topics: Anti-Bacterial Agents; Brefeldin A; Cell Line; Chloroquine; Cyclopentanes; Cytotoxicity, Immunologic; Histocompatibility Antigens Class I; Histocompatibility Antigens Class II; Humans; Influenza A virus; Kinetics; Recombination, Genetic; T-Lymphocytes; T-Lymphocytes, Cytotoxic; Vaccinia virus; Viral Matrix Proteins | 1990 |
Novel blockade by brefeldin A of intracellular transport of secretory proteins in cultured rat hepatocytes.
Topics: Adenosine Triphosphate; alpha 1-Antitrypsin; alpha-Fetoproteins; Animals; Asialoglycoproteins; Blood Proteins; Body Fluids; Brefeldin A; Carbohydrate Metabolism; Carbonyl Cyanide m-Chlorophenyl Hydrazone; Cyclopentanes; Endocytosis; Fetuins; Haptoglobins; Intracellular Fluid; Liver; Microscopy, Electron; Prealbumin; Protein Processing, Post-Translational; Proteins; Rats; Time Factors | 1986 |
Blockade by brefeldin A of intracellular transport of secretory proteins in mouse pituitary cells: effects on the biosynthesis of thyrotropin and free alpha-subunits.
Topics: Animals; Biological Transport; Brefeldin A; Cyclopentanes; Cytoplasmic Granules; Endoplasmic Reticulum; Female; Fucose; Glycoprotein Hormones, alpha Subunit; Glycoproteins; Hypothyroidism; Methionine; Mice; Microscopy, Electron; Pituitary Gland; Pituitary Hormones, Anterior; Proteins; Sulfates; Thyrotropin | 1988 |
Brefeldin A specifically inhibits presentation of protein antigens to cytotoxic T lymphocytes.
Topics: Animals; Antigen-Presenting Cells; Antigens, Viral; Biological Transport; Brefeldin A; Cell Membrane; Cyclopentanes; Endoplasmic Reticulum; Epitopes; Exocytosis; Golgi Apparatus; H-2 Antigens; Hemagglutinins; Histocompatibility Antigens Class I; Mice; Nucleoproteins; Orthomyxoviridae; T-Lymphocytes, Cytotoxic; Transfection; Viral Proteins | 1989 |
Brefeldin A inhibits oligosaccharide processing of glycoproteins in mouse hypothyroid pituitary tissue at several subcellular sites.
Topics: Acetylglucosaminidase; Animals; Brefeldin A; Cyclopentanes; Electrophoresis, Polyacrylamide Gel; Female; Fucose; Galactose; Glycoproteins; Glycosylation; Hexosamines; Hypothyroidism; Immunosorbent Techniques; Mannose; Mannosyl-Glycoprotein Endo-beta-N-Acetylglucosaminidase; Methionine; Mice; Monensin; Oligosaccharides; Pituitary Gland; Sulfates; Thyrotropin; Trypsin | 1989 |
Dynamic distribution of the Golgi marker thiamine pyrophosphatase is modulated by brefeldin A in rat hepatoma cells.
Topics: Animals; Brefeldin A; Cyclopentanes; Golgi Apparatus; Histocytochemistry; Liver Neoplasms, Experimental; Microscopy, Electron; Pyrophosphatases; Rats; Thiamine Pyrophosphatase; Tumor Cells, Cultured | 1989 |
Selective cytotoxic activity of brefeldin A against human tumor cell lines.
Topics: Animals; Antifungal Agents; Antiviral Agents; Brefeldin A; Cell Line; Cell Survival; Cyclopentanes; Doxorubicin; Drug Evaluation, Preclinical; Humans; Mice; Tumor Cells, Cultured | 1989 |
Rapid redistribution of Golgi proteins into the ER in cells treated with brefeldin A: evidence for membrane cycling from Golgi to ER.
Topics: Animals; Brefeldin A; Cell Compartmentation; Cyclopentanes; Endoplasmic Reticulum; Fluorescent Antibody Technique; Golgi Apparatus; In Vitro Techniques; Intracellular Membranes; Mannosidases; Membrane Glycoproteins; Mice; Microscopy, Electron; Protein Processing, Post-Translational; Receptors, Antigen, T-Cell | 1989 |
Effects of brefeldin A on the synthesis and secretion of egg white proteins in primary cultured oviduct cells of laying Japanese quail (Coturnix coturnix japonica).
Topics: Animals; Brefeldin A; Cells, Cultured; Chromatography, Affinity; Conalbumin; Coturnix; Cyclopentanes; Egg Proteins; Electrophoresis, Polyacrylamide Gel; Female; Glycopeptides; Monensin; Oligosaccharides; Ovalbumin; Oviducts; Ovomucin; Quail | 1989 |
Brefeldin A redistributes resident and itinerant Golgi proteins to the endoplasmic reticulum.
Topics: Animals; Biological Transport; Brefeldin A; Cell Compartmentation; Cells, Cultured; Cricetinae; Cyclopentanes; Endoplasmic Reticulum; Glycosylation; Golgi Apparatus; Membrane Glycoproteins; Monensin; Precipitin Tests; Protein Processing, Post-Translational; Temperature; Time Factors; Viral Envelope Proteins | 1989 |
Brefeldin A inhibits the targeting of cathepsin D and cathepsin H to lysosomes in rat hepatocytes.
Topics: Animals; Biological Transport; Brefeldin A; Cathepsin D; Cathepsin H; Cathepsins; Cell Compartmentation; Cells, Cultured; Cyclopentanes; Cysteine Endopeptidases; Golgi Apparatus; Liver; Lysosomes; Protein Processing, Post-Translational; Rats | 1989 |
Targeting and processing of glycophorins in murine erythroleukemia cells: use of brefeldin A as a perturbant of intracellular traffic.
Topics: Animals; Antifungal Agents; Brefeldin A; Cell Line; Cyclopentanes; Glycophorins; Glycosylation; Kinetics; Leukemia, Erythroblastic, Acute; Mice; Microscopy, Electron; Neoplasm Proteins; Protein Processing, Post-Translational; Sialoglycoproteins | 1989 |
Brefeldin A implicates egress from endoplasmic reticulum in class I restricted antigen presentation.
Topics: Antigens, Viral; Brefeldin A; Cell Line; Cyclopentanes; Cytosol; Cytotoxicity, Immunologic; Endoplasmic Reticulum; Histocompatibility Antigens Class I; Humans; T-Lymphocytes, Cytotoxic | 1989 |
The effects of brefeldin-A on the high mannose oligosaccharides of mouse thyrotropin, free alpha-subunits, and total glycoproteins.
Topics: Animals; Brefeldin A; Chromatography, Paper; Cyclopentanes; Fucosyltransferases; Galactosyltransferases; Glycoproteins; Macromolecular Substances; Mannose; Mice; Oligosaccharides; Protein Processing, Post-Translational; Thyroid Neoplasms; Thyrotropin | 1988 |
Brefeldin A causes disassembly of the Golgi complex and accumulation of secretory proteins in the endoplasmic reticulum.
Topics: Animals; Antiviral Agents; Brefeldin A; Cells, Cultured; Cyclopentanes; Endoplasmic Reticulum; Golgi Apparatus; Liver; Male; Microscopy, Electron; Proteins; Rats; Rats, Inbred Strains | 1988 |
Brefeldin A arrests the intracellular transport of a precursor of complement C3 before its conversion site in rat hepatocytes.
Topics: Animals; Biological Transport, Active; Brefeldin A; Cells, Cultured; Complement C3; Cyclopentanes; Golgi Apparatus; Liver; Protein Precursors; Protein Processing, Post-Translational; Rats | 1987 |
Induction and suppression of phytoalexin biosynthesis in cultured cells of safflower, Carthamus tinctorius L., by metabolites of Alternaria carthami Chowdhury.
Topics: Alternaria; Brefeldin A; Cell Extracts; Cell Wall; Cells, Cultured; Cyclopentanes; Fungi; Kinetics; Mitosporic Fungi; Phytoalexins; Phytophthora; Plant Extracts; Plant Proteins; Plants; Sesquiterpenes; Terpenes | 1984 |
Biosynthesis of brefeldin A. Introduction of oxygen at the C-7 position.
Topics: Antifungal Agents; Brefeldin A; Cyclopentanes; Magnetic Resonance Spectroscopy; Oxygen; Stereoisomerism | 1983 |
Differential response of cultured parsley cells to elicitors from two non-pathogenic strains of fungi. 1. Identification of induced products as coumarin derivatives.
Topics: Alternaria; Brefeldin A; Cells, Cultured; Coumarins; Cyclopentanes; Fungi; Mitosporic Fungi; Mycotoxins; Phytoalexins; Phytophthora; Plant Extracts; Plant Proteins; Plants; Sesquiterpenes; Terpenes | 1983 |
Studies on the mechanism of synergistic action with synergisidin and imidazole antimycotics.
Topics: Amino Acids; Antifungal Agents; Brefeldin A; Candida albicans; Cyclopentanes; Drug Resistance, Microbial; Drug Synergism; Fatty Acids; Imidazoles; Lipids; Osmotic Pressure; Vitamins | 1981 |
Biochemical changes accompanying brefeldin A formation in Curvularia lunata.
Topics: Anti-Bacterial Agents; Brefeldin A; Culture Media; Cyclopentanes; Fatty Acids, Nonesterified; Glucose; Hydrogen-Ion Concentration; Mitosporic Fungi | 1980 |
Effect of substrates on the malonate inhibitory pattern and brefeldin A formation in Curvularia lunata.
Topics: Anti-Bacterial Agents; Brefeldin A; Carboxylic Acids; Cyclopentanes; Malonates; Mitosporic Fungi | 1981 |
Studies on synergisidin.
Topics: Antifungal Agents; Bacteria; Brefeldin A; Candida; Cells, Cultured; Chemical Phenomena; Chemistry; Chemistry, Physical; Cyclopentanes; Drug Resistance, Microbial; Drug Synergism; Fermentation; Humans; Penicillium | 1981 |
Role of a potential endoplasmic reticulum retention sequence (RDEL) and the Golgi complex in the cytotonic activity of Escherichia coli heat-labile enterotoxin.
Topics: Amino Acid Sequence; Animals; Anti-Bacterial Agents; Bacterial Toxins; Base Sequence; Brefeldin A; Cell Line; CHO Cells; Cricetinae; Cyclic AMP; Cyclopentanes; DNA, Bacterial; Endoplasmic Reticulum; Enterotoxins; Escherichia coli; Escherichia coli Proteins; Golgi Apparatus; Molecular Sequence Data; Mutagenesis, Site-Directed; Mutation; Protein Conformation | 1995 |
Chloride secretion induced by phorbol dibutyrate and forskolin in the human colonic carcinoma cell line HT-29Cl.19A is regulated by different mechanisms.
Topics: Brefeldin A; Chloride Channels; Chlorides; Colforsin; Cyclopentanes; Cystic Fibrosis Transmembrane Conductance Regulator; Demecolcine; Electric Stimulation; HT29 Cells; Humans; Ionophores; Microelectrodes; Nocodazole; Nystatin; Phorbol 12,13-Dibutyrate; Protein Synthesis Inhibitors; Temperature | 1995 |
Accumulation of Golgi-specific mannosyltransferases in Candida albicans cells grown in the presence of brefeldin A.
Topics: Antifungal Agents; Brefeldin A; Candida albicans; Carbohydrate Sequence; Cell-Free System; Cyclopentanes; Golgi Apparatus; Mannans; Mannosyltransferases; Molecular Sequence Data | 1995 |
Brefeldin A reversibly inhibits the assembly of apoB containing lipoproteins in McA-RH7777 cells.
Topics: Apolipoprotein B-100; Apolipoprotein B-48; Apolipoproteins B; Biological Transport; Brefeldin A; Cell Line; Cyclopentanes; Intracellular Membranes; Lipoproteins, VLDL; Microsomes; Protein Processing, Post-Translational; Protein Synthesis Inhibitors; Triglycerides | 1995 |
Ultrastructure of proteinase-secreting cells of Candida albicans studied by alkaline bismuth staining and immunocytochemistry.
Topics: Bismuth; Brefeldin A; Candida albicans; Cross Reactions; Cyclopentanes; Cytoplasmic Granules; Endopeptidases; Enzyme Induction; Glycogen; Immunoblotting; Immunohistochemistry; Microscopy, Electron; Protein Synthesis Inhibitors; Staining and Labeling | 1993 |
Polarization-dependent apical membrane CFTR targeting underlies cAMP-stimulated Cl- secretion in epithelial cells.
Topics: Brefeldin A; Cell Line; Cell Membrane; Cell Polarity; Chlorides; Colon; Cyclic AMP; Cyclopentanes; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Electric Conductivity; Fluorescent Antibody Technique; Glycosylation; Humans; Intestinal Mucosa; Membrane Proteins; Precipitin Tests; RNA, Messenger | 1994 |
Intracellular trafficking and activation of the furin proprotein convertase: localization to the TGN and recycling from the cell surface.
Topics: Amino Acid Sequence; Animals; Base Sequence; Brefeldin A; Cell Line; Cell Membrane; Cyclopentanes; DNA; Enzyme Activation; Epitopes; Fluorescent Antibody Technique; Furin; Golgi Apparatus; Humans; Molecular Sequence Data; Protein Precursors; Subtilisins | 1994 |
Action of brefeldin A on amphibian neurons: passage of newly synthesized proteins through the Golgi complex is not required for continued fast organelle transport in axons.
Topics: Animals; Axonal Transport; Axons; Brefeldin A; Choline; Cyclopentanes; Ethanolamine; Ethanolamines; Ganglia, Spinal; Golgi Apparatus; Kinetics; Leucine; Microscopy, Electron; Nerve Tissue Proteins; Neurons; Organelles; Peripheral Nerves; Protein Synthesis Inhibitors; Rana catesbeiana; Spinal Nerve Roots; Time Factors; Tritium; Xenopus laevis | 1994 |
Nitric oxide synthase in cerebrovascular endothelial cells is inhibited by brefeldin A.
Topics: Amino Acid Oxidoreductases; Animals; Brefeldin A; Cattle; Cerebrovascular Circulation; Citrulline; Cyclopentanes; Endothelium, Vascular; Golgi Apparatus; Nerve Tissue Proteins; Nitric Oxide Synthase; Protein Synthesis Inhibitors | 1994 |
Post-translational processing of the inter-alpha-trypsin inhibitor in the human hepatoma HepG2 cell line.
Topics: Alpha-Globulins; Brefeldin A; Carcinoma, Hepatocellular; Chondroitinases and Chondroitin Lyases; Cyclopentanes; Electrophoresis, Polyacrylamide Gel; Glycosides; Glycosylation; Humans; Liver Neoplasms; Monensin; Precipitin Tests; Protein Precursors; Protein Processing, Post-Translational; Protein Synthesis Inhibitors; Receptors, Cell Surface; Sulfates; Trypsin Inhibitors; Tumor Cells, Cultured | 1994 |
Intracellular turnover of cystic fibrosis transmembrane conductance regulator. Inefficient processing and rapid degradation of wild-type and mutant proteins.
Topics: Amino Acid Sequence; Brefeldin A; Carcinoma; Cell Compartmentation; Colonic Neoplasms; Cyclopentanes; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Endoplasmic Reticulum; Glycosylation; Humans; Membrane Proteins; Molecular Sequence Data; Mutation; Protein Biosynthesis; Protein Folding; Protein Precursors; Protein Processing, Post-Translational; Protein Synthesis Inhibitors; Recombinant Proteins; Transfection; Tumor Cells, Cultured | 1994 |
Phosphatase inhibitors block in vivo binding of peptides to class I major histocompatibility complex molecules.
Topics: alpha-Macroglobulins; Animals; B-Lymphocytes; Biological Transport; Brefeldin A; Cantharidin; Cell Compartmentation; Cyclopentanes; Endoplasmic Reticulum; Ethers, Cyclic; H-2 Antigens; Histocompatibility Antigens Class I; HLA-B Antigens; Humans; Mice; Okadaic Acid; Peptides; Phosphoric Monoester Hydrolases; Polysaccharides; Protein Binding; Protein Processing, Post-Translational | 1994 |
Mitotic arrest with anti-microtubule agents or okadaic acid is associated with increased glycoprotein terminal GlcNAc's.
Topics: Acetylglucosamine; Acid Phosphatase; Alkaloids; Aphidicolin; Brefeldin A; Cell Cycle; Cell Line; Colon; Cyclopentanes; Epithelium; Ethers, Cyclic; G2 Phase; Glycoproteins; Glycosylation; Golgi Apparatus; HeLa Cells; Humans; Keratins; Microtubules; Mitosis; Nocodazole; Okadaic Acid; Protein Kinase C; Protein Synthesis Inhibitors; Staurosporine | 1994 |
Biosynthesis of mucin derived from a 60-kDa precursor protein in the human stomach.
Topics: Antibodies, Monoclonal; Brefeldin A; Culture Techniques; Cyclopentanes; Gastric Mucins; Gastric Mucosa; Humans; Molecular Weight; Monensin; Precipitin Tests; Protein Precursors; Protein Synthesis Inhibitors; Tunicamycin | 1994 |
Intracellular processing and presentation of T cell epitopes, expressed by recombinant Escherichia coli and Salmonella typhimurium, to human T cells.
Topics: Amino Acid Sequence; Antigen Presentation; Base Sequence; Brefeldin A; Cycloheximide; Cyclopentanes; Cytochalasin D; Epitopes; Escherichia coli; Escherichia coli Proteins; Humans; Macrophages; Molecular Sequence Data; Porins; Recombinant Fusion Proteins; Salmonella typhimurium; T-Lymphocytes; Viral Proteins | 1995 |
Beta 1- and beta 3-class integrins mediate fibronectin binding activity at the surface of developing mouse peri-implantation blastocysts. Regulation by ligand-induced mobilization of stored receptor.
Topics: Amino Acid Sequence; Animals; Antibodies, Monoclonal; Antigens, CD; Binding, Competitive; Blastocyst; Brefeldin A; Cell Adhesion; Cell Membrane; Cells, Cultured; Cyclopentanes; Cytochalasin B; Cytochalasin D; Female; Fibronectins; Heparitin Sulfate; Integrin beta1; Integrin beta3; Integrins; Kinetics; Laminin; Mice; Mice, Inbred Strains; Microspheres; Molecular Sequence Data; Oligopeptides; Protein Synthesis Inhibitors; Receptors, Fibronectin | 1995 |
Influence of compounds affecting synthesis, modification and transport of proteins on the expression and release of interleukin-2 receptor.
Topics: Aprotinin; Brefeldin A; Cells, Cultured; Cyclopentanes; Cytochalasins; Enzyme-Linked Immunosorbent Assay; Flow Cytometry; Humans; Lymphocyte Activation; Lymphocytes; Monensin; Protein Biosynthesis; Protein Synthesis Inhibitors; Proteins; Receptors, Interleukin-2; Vinca Alkaloids | 1995 |
Effects of brefeldin A on the formation of the cell plate in tobacco BY-2 cells.
Topics: Anti-Bacterial Agents; Brefeldin A; Cell Division; Cell Nucleus; Cells, Cultured; Cyclopentanes; Golgi Apparatus; Microscopy, Electron; Mitotic Index; Nicotiana; Plants, Toxic; Staining and Labeling | 1995 |
Brefeldin A provokes indirect activation of cdc2 kinase (MPF) in Xenopus oocytes, resulting in meiotic cell division.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Brefeldin A; CDC2 Protein Kinase; Cell Cycle; Cholera Toxin; Colforsin; Cyclic AMP; Cycloheximide; Cyclopentanes; Enzyme Activation; Maturation-Promoting Factor; Meiosis; Oocytes; Oogenesis; Peptide Elongation Factor 1; Peptide Elongation Factors; Phosphorylation; Progesterone; Protamine Kinase; Protein Processing, Post-Translational; Signal Transduction; Xenopus laevis | 1995 |
A study of the intracellular routing of cytotoxic ribonucleases.
Topics: Amino Acid Sequence; Animals; Antineoplastic Agents; Base Sequence; Brefeldin A; Cattle; Cell Survival; Cyclopentanes; Egg Proteins; Golgi Apparatus; Humans; Molecular Sequence Data; Monensin; Proteins; Rats; Ribonuclease, Pancreatic; Ribonucleases; RNA; Tretinoin; Tumor Cells, Cultured | 1995 |
Fluorescent conjugates of brefeldin A selectively stain the endoplasmic reticulum and Golgi complex of living cells.
Topics: Animals; Boron Compounds; Brefeldin A; Cell Line; Chromatography, High Pressure Liquid; Cyclopentanes; Endoplasmic Reticulum; Fluorescent Antibody Technique; Fluorescent Dyes; Golgi Apparatus; L Cells; Mice; Molecular Structure; Protein Synthesis Inhibitors; Staining and Labeling | 1995 |
Biosynthesis of GlyCAM-1, a mucin-like ligand for L-selectin.
Topics: Animals; Brefeldin A; Carbohydrate Sequence; Cell Adhesion Molecules; Cold Temperature; Cyclopentanes; Glycosylation; In Vitro Techniques; L-Selectin; Ligands; Lymph Nodes; Mice; Molecular Sequence Data; Mucins; Oligosaccharides; Protein Processing, Post-Translational; Sulfates | 1995 |
Sorting and intracellular trafficking of a glycosylphosphatidylinositol-anchored protein and two hybrid transmembrane proteins with the same ectodomain in Madin-Darby canine kidney epithelial cells.
Topics: Alkaline Phosphatase; Amino Acid Sequence; Animals; Base Sequence; Biological Transport, Active; Brefeldin A; Cell Line; Cell Membrane; Cell Polarity; Cyclopentanes; Dogs; Female; Glycosylphosphatidylinositols; Kidney; Membrane Proteins; Molecular Sequence Data; Monensin; Nocodazole; Octoxynol; Placenta; Plasmids; Pregnancy; Recombinant Fusion Proteins; Solubility | 1995 |
Effects of brefeldin A on synthesis and intracellular transport of ganglioside GT3 by chick embryo retina cells.
Topics: Animals; Biological Transport; Brefeldin A; Cell Membrane; Cells, Cultured; Chick Embryo; Cyclopentanes; G(M3) Ganglioside; Gangliosides; Lactosylceramides; Retina | 1995 |
Effects of brefeldin A on galactosphingolipid synthesis in an immortalized Schwann cell line: evidence for different intracellular locations of galactosylceramide sulfotransferase and ceramide galactosyltransferase activities.
Topics: Animals; Brefeldin A; Cell Line, Transformed; Ceramides; Cyclopentanes; Galactosylceramides; Galactosyltransferases; Glycosphingolipids; Intracellular Membranes; N-Acylsphingosine Galactosyltransferase; Palmitic Acid; Palmitic Acids; Rats; Schwann Cells; Sulfates; Sulfotransferases; Tissue Distribution | 1995 |
Sorting and budding of constitutive secretory vesicles in hepatocytes and hepatoma cells.
Topics: Animals; Brefeldin A; Carrier Proteins; Cell Line; Cyclopentanes; Cytoplasmic Granules; Glycoproteins; Golgi Apparatus; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Heparan Sulfate Proteoglycans; Heparitin Sulfate; Liver; Liver Neoplasms, Experimental; Membrane Glycoproteins; Membrane Proteins; Proteoglycans; Rats; SNARE Proteins; Tumor Cells, Cultured; Vesicular Transport Proteins | 1995 |
A role for calmodulin in organelle membrane tubulation.
Topics: Animals; Brefeldin A; Calmodulin; Cells, Cultured; Clathrin; Coatomer Protein; Cyclopentanes; HeLa Cells; Humans; Intracellular Membranes; Kidney; Liver; Membrane Proteins; Microtubule-Associated Proteins; Microtubules; Organelles; Rats; Receptor, IGF Type 2; Receptors, Transferrin; Transferrin | 1995 |
Recycling of a glycosylphosphatidylinositol-anchored heparan sulphate proteoglycan (glypican) in skin fibroblasts.
Topics: Biotin; Brefeldin A; Cell Membrane; Cells, Cultured; Cyclopentanes; Embryo, Mammalian; Fibroblasts; Glucosamine; Glycosylphosphatidylinositols; Heparan Sulfate Proteoglycans; Heparitin Sulfate; Humans; Inositol; Protein Synthesis Inhibitors; Proteoglycans; Sulfates; Sulfur Radioisotopes; Suramin; Tritium; Type C Phospholipases | 1995 |
Control of the surface expression of uvomorulin after activation of mouse oocytes.
Topics: Animals; Anisomycin; Biological Transport; Brefeldin A; Cadherins; Cell Compartmentation; Cell Cycle; Cell Membrane; Cyclopentanes; Cytochalasin D; Female; Fertilization; Male; Mice; Monensin; Nocodazole; Oocytes; Protein Synthesis Inhibitors; Puromycin | 1995 |
Protective effect of cell-permeable ceramide analogs against modeccin, ricin, Pseudomonas toxin, and diphtheria toxin.
Topics: Animals; Anti-Bacterial Agents; Bacterial Toxins; Brefeldin A; Cell Line; Cell Membrane Permeability; Ceramides; Chlorocebus aethiops; Cyclopentanes; Diphtheria Toxin; Dogs; Kidney; Lectins; Phosphoprotein Phosphatases; Plant Lectins; Protein Binding; Protein Kinases; Proteins; Pseudomonas; Ribosome Inactivating Proteins, Type 2; Ricin; Sphingomyelin Phosphodiesterase; Vero Cells | 1995 |
Ricin toxicity and intracellular routing in tumoral HT-29 cells. I. Ricin routing and toxicity are related to the state of differentiation of HT-29 cells.
Topics: Biological Transport; Brefeldin A; Cell Differentiation; Cell Fractionation; Cyclopentanes; Endoplasmic Reticulum; Golgi Apparatus; HT29 Cells; Humans; Iodine Radioisotopes; Monensin; Ricin; Subcellular Fractions; Time Factors | 1995 |
Isolation of brefeldin A.
Topics: Anti-Bacterial Agents; Antiviral Agents; Brefeldin A; Chromatography, High Pressure Liquid; Cyclopentanes; Macrolides; Penicillium; Sensitivity and Specificity; Solvents | 1995 |
Furin, PC1/3, and/or PC6A process rabbit, but not human, pro-lactase-phlorizin hydrolase to the 180-kDa intermediate.
Topics: Amino Acid Sequence; Animals; Aspartic Acid Endopeptidases; Brefeldin A; Cloning, Molecular; Cyclopentanes; Enzyme Precursors; Furin; Humans; In Situ Hybridization; Intestine, Small; Lactase-Phlorizin Hydrolase; Mice; Molecular Sequence Data; Organ Culture Techniques; Polymerase Chain Reaction; Proprotein Convertase 1; Proprotein Convertase 5; Proprotein Convertases; Protein Processing, Post-Translational; Rabbits; Rats; Recombinant Proteins; RNA, Messenger; Sequence Analysis, DNA; Serine Endopeptidases; Species Specificity; Substrate Specificity; Subtilisins; Tissue Distribution; Transfection | 1995 |
The Brefeldin A-induced retrograde transport from the Golgi apparatus to the endoplasmic reticulum depends on calcium sequestered to intracellular stores.
Topics: Biological Transport; Brefeldin A; Calcimycin; Calcium; Cell Compartmentation; Cyclopentanes; Dipeptides; Endoplasmic Reticulum; Glycosylation; Golgi Apparatus; HeLa Cells; Humans; Ionophores; Membrane Proteins; Metalloendopeptidases; Peptide Fragments; Protease Inhibitors; Protein Processing, Post-Translational | 1995 |
Tissue-specific processing of the neuroendocrine protein VGF.
Topics: Adrenal Medulla; Animals; Brefeldin A; Cell Line; Central Nervous System; Cerebellum; Cyclopentanes; Cytoplasmic Granules; Endocrine Glands; Mice; Nerve Growth Factors; Neurons; Neuropeptides; Neurosecretory Systems; Peptide Hydrolases; Protein Processing, Post-Translational; Protein Synthesis Inhibitors; Proteins; Rats | 1995 |
Brefeldin A inhibits the transcytotic vesicular transport of horseradish peroxidase in intrahepatic bile ductules isolated from rat liver.
Topics: Animals; Bile Ducts, Intrahepatic; Biological Transport; Brefeldin A; Cyclopentanes; Horseradish Peroxidase; In Vitro Techniques; Male; Rats; Rats, Sprague-Dawley; Taurocholic Acid; Thiamine Pyrophosphatase; Tissue Distribution | 1995 |
Exogenous nonphysiologic vs physiologic lipids. Divergent mechanisms for correction of permeability barrier dysfunction.
Topics: Animals; Brefeldin A; Cyclopentanes; Lipids; Male; Mice; Mice, Hairless; Monensin; Permeability; Petrolatum; Protein Synthesis Inhibitors; Skin | 1995 |
Brefeldin A and a synthetic peptide to ADP-ribosylation factor (ARF) inhibit regulated exocytosis in melanotrophs.
Topics: Adenylyl Cyclases; ADP-Ribosylation Factors; Amino Acid Sequence; Animals; Brefeldin A; Calcium; Chromatography, High Pressure Liquid; Cyclopentanes; Exocytosis; GTP-Binding Proteins; Molecular Sequence Data; Patch-Clamp Techniques; Pituitary Gland, Anterior; Protein Synthesis Inhibitors; Rats | 1995 |
Purification and characterization of a Shiga toxin A subunit-CD4 fusion protein cytotoxic to human immunodeficiency virus-infected cells.
Topics: Ammonium Chloride; Animals; Bacterial Toxins; Base Sequence; Brefeldin A; CD4 Antigens; Cell Compartmentation; Cell Line; Chlorocebus aethiops; Chloroquine; Cyclopentanes; Cytotoxins; DNA Primers; HIV Infections; Humans; In Vitro Techniques; Molecular Sequence Data; Recombinant Fusion Proteins; Shiga Toxins; Vero Cells | 1995 |
Characterization of mucins and proteoglycans synthesized by a mucin-secreting HT-29 cell subpopulation.
Topics: Acetylgalactosamine; Benzyl Compounds; beta-Galactoside alpha-2,3-Sialyltransferase; Brefeldin A; Carbohydrate Sequence; Colonic Neoplasms; Cyclopentanes; Disaccharides; Humans; Molecular Sequence Data; Molecular Structure; Mucins; Proteoglycans; Sialic Acids; Sialyltransferases; Tumor Cells, Cultured | 1995 |
Evidence that the 50-kDa substrate of brefeldin A-dependent ADP-ribosylation binds GTP and is modulated by the G-protein beta gamma subunit complex.
Topics: Adenosine Diphosphate Ribose; Affinity Labels; Animals; Brain; Brefeldin A; Cattle; Cells, Cultured; Cyclopentanes; Cytosol; Electrophoresis, Gel, Two-Dimensional; GTP-Binding Proteins; Guanine Nucleotides; Guanosine Triphosphate; Membrane Proteins; Protein Binding; Protein Conformation; Protein Processing, Post-Translational; Rats; Thyroid Gland | 1995 |
Intracellular degradation of type I collagen and fibronectin in human lung fibroblasts: evidence against degradation in pre-lysosomal compartments.
Topics: 2,2'-Dipyridyl; Biological Transport; Brefeldin A; Canavanine; Cell Line; Cell Membrane Permeability; Chloroquine; Collagen; Cyclopentanes; Cysteine Proteinase Inhibitors; Endoplasmic Reticulum; Fibroblasts; Fibronectins; Golgi Apparatus; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Hydroxybenzoates; Lung; Monensin; Organelles; Protein Folding; Protein Synthesis Inhibitors | 1995 |
Sphingomyelin is synthesized at the plasma membrane of oligodendrocytes and by purified myelin membranes: a study with fluorescent- and radio-labelled ceramide analogues.
Topics: Animals; Biological Transport; Brefeldin A; Cell Membrane; Cells, Cultured; Ceramides; Cold Temperature; Cyclopentanes; Fluorescent Dyes; Golgi Apparatus; Monensin; Myelin Sheath; Oligodendroglia; Phosphatidylcholines; Rats; Rats, Wistar; Sphingomyelins; Spinal Cord | 1995 |
Characterization of TAP-independent and brefeldin A-resistant presentation of Sendai virus antigen to CD8+ cytotoxic T lymphocytes.
Topics: Amino Acid Sequence; Animals; Antigen Presentation; Antigens, Viral; ATP Binding Cassette Transporter, Subfamily B, Member 2; ATP Binding Cassette Transporter, Subfamily B, Member 3; ATP-Binding Cassette Transporters; Brefeldin A; Cell Line; Chromatography, High Pressure Liquid; Cyclopentanes; Drug Resistance; Genetic Vectors; Immunodominant Epitopes; Mice; Molecular Sequence Data; Parainfluenza Virus 1, Human; T-Lymphocytes, Cytotoxic | 1995 |
Myxoma virus induces extensive CD4 downregulation and dissociation of p56lck in infected rabbit CD4+ T lymphocytes.
Topics: Alkaloids; Animals; Antiviral Agents; Brefeldin A; CD4 Antigens; CD4-Positive T-Lymphocytes; Cell Line; Cyclopentanes; Flow Cytometry; Gene Expression; Genes, Viral; Immunity, Cellular; Lymphocyte Specific Protein Tyrosine Kinase p56(lck); Lysosomes; Myxoma virus; Protein Kinase C; Protein-Tyrosine Kinases; Rabbits; Staurosporine; Tetradecanoylphorbol Acetate | 1995 |
Brefeldin A inhibits the endocytosis of plasma-membrane-associated heparan sulphate proteoglycans of cultured rat ovarian granulosa cells.
Topics: Animals; Brefeldin A; Cell Membrane; Cells, Cultured; Cycloheximide; Cyclopentanes; Endocytosis; Female; Granulosa Cells; Heparan Sulfate Proteoglycans; Heparitin Sulfate; Hydrolysis; Iodine Radioisotopes; Proteoglycans; Rats; Rats, Sprague-Dawley; Ricin; Transferrin | 1995 |
Characterization of a novel Schizosaccharomyces pombe multidrug resistance transporter conferring brefeldin A resistance.
Topics: Adenosine Triphosphate; Amino Acid Sequence; ATP-Binding Cassette Transporters; Base Sequence; Binding Sites; Brefeldin A; Cloning, Molecular; Cyclopentanes; DNA, Fungal; Drug Resistance, Multiple; Fungal Proteins; Molecular Sequence Data; Open Reading Frames; Pancreatitis-Associated Proteins; Restriction Mapping; Schizosaccharomyces; Schizosaccharomyces pombe Proteins; Sequence Analysis; Sequence Homology | 1995 |
Secretion of plasminogen activator and lysosomal enzymes from mouse skeletal muscle: effect of denervation.
Topics: Animals; beta-Galactosidase; Brefeldin A; Cold Temperature; Cyclopentanes; Glucuronidase; Lysosomes; Male; Mannans; Mice; Muscle Denervation; Muscles; Plasminogen Activators; Urokinase-Type Plasminogen Activator | 1995 |
Endoproteolytic cleavage of HIV-1 gp160 envelope precursor occurs after exit from the trans-Golgi network (TGN).
Topics: Aluminum Compounds; Biological Transport; Brefeldin A; Cyclopentanes; Fluorides; Gene Products, env; Golgi Apparatus; HIV Envelope Protein gp160; HIV-1; Humans; Protein Precursors; Protein Processing, Post-Translational; Temperature; Tumor Cells, Cultured; Viral Envelope Proteins | 1995 |
Production of brefeldin-A.
Topics: Antibiotics, Antineoplastic; Brefeldin A; Chromatography, High Pressure Liquid; Cyclopentanes; Fermentation; Industrial Microbiology; Penicillium; Time Factors | 1995 |
Comparative localization of mannose-6-phosphate receptor with 2,6sialyltransferase in HepG2 cells: an analysis by confocal double immunofluorescence microscopy.
Topics: Adaptor Protein Complex gamma Subunits; beta-D-Galactoside alpha 2-6-Sialyltransferase; Brefeldin A; Carcinoma, Hepatocellular; Cell Compartmentation; Cyclopentanes; Endosomes; Fluorescent Antibody Technique; Golgi Apparatus; Humans; Liver; Membrane Proteins; Microscopy, Confocal; Microscopy, Fluorescence; N-Acetyllactosamine Synthase; Receptor, IGF Type 2; Sialyltransferases; Tumor Cells, Cultured | 1995 |
Aspects of cellular physiology that influence DNA-mediate gene transfer in NIH3T3 cells.
Topics: 3T3 Cells; Animals; Brefeldin A; Colchicine; Cycloheximide; Cyclopentanes; Cytochalasin B; Dichlororibofuranosylbenzimidazole; DNA; Gene Transfer Techniques; Mice; RNA, Messenger; Transformation, Genetic | 1995 |
Visualization of Golgi complexes and spermatogonial cohorts of viable, intact seminiferous tubules.
Topics: 4-Chloro-7-nitrobenzofurazan; Animals; Brefeldin A; Ceramides; Cyclopentanes; Fluorescent Dyes; Golgi Apparatus; Male; Microscopy, Fluorescence; Rats; Rats, Sprague-Dawley; Seminiferous Tubules; Sertoli Cells; Spermatogonia; Staining and Labeling | 1993 |
Comparison of antigen presentation of influenza A nucleoprotein expressed in attenuated AroA- Salmonella typhimurium with that of live virus.
Topics: 3-Phosphoshikimate 1-Carboxyvinyltransferase; Alkyl and Aryl Transferases; Animals; Antigen-Presenting Cells; Antigens, Differentiation, T-Lymphocyte; Bacterial Proteins; Brefeldin A; Cycloheximide; Cyclopentanes; Epitopes; Female; Genetic Vectors; Histocompatibility Antigens Class I; Humans; Influenza A virus; Kinetics; Macrophages; Mice; Mice, Inbred BALB C; Monocytes; Nucleocapsid Proteins; Nucleoproteins; Phagocytosis; Protease Inhibitors; RNA-Binding Proteins; Salmonella typhimurium; Tumor Cells, Cultured; Viral Core Proteins; Virulence | 1993 |
Receptor and protein kinase C-mediated regulation of ARF binding to the Golgi complex.
Topics: ADP-Ribosylation Factors; Aluminum; Animals; Brefeldin A; Cell Membrane Permeability; Coatomer Protein; Cyclopentanes; Enzyme Activation; Fluorine; Glycosaminoglycans; Golgi Apparatus; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Triphosphate; Microtubule-Associated Proteins; Naphthalenes; Phorbol Esters; Polycyclic Compounds; Protein Binding; Protein Kinase C; Rats; Receptors, IgE; Second Messenger Systems; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1993 |
Double immunofluorescent staining of alpha 2,6 sialyltransferase and beta 1,4 galactosyltransferase in monensin-treated cells: evidence for different Golgi compartments?
Topics: Antibodies, Monoclonal; Base Sequence; beta-D-Galactoside alpha 2-6-Sialyltransferase; Brefeldin A; Cell Compartmentation; Chloroquine; Cyclopentanes; Fluorescent Antibody Technique; Golgi Apparatus; HeLa Cells; Humans; Molecular Sequence Data; Monensin; N-Acetyllactosamine Synthase; Nocodazole; Sialyltransferases; Staining and Labeling; Tumor Cells, Cultured | 1993 |
Epitope-specific enhancement of antigen presentation by invariant chain.
Topics: Animals; Antigen-Presenting Cells; Antigens, Differentiation, B-Lymphocyte; Brefeldin A; Cells, Cultured; Chloroquine; Cyclopentanes; Epitopes; HeLa Cells; Histocompatibility Antigens Class II; Humans; Hybridomas; Rats | 1993 |
Multisubunit assembly of an integral plasma membrane channel protein, gap junction connexin43, occurs after exit from the ER.
Topics: Animals; Anti-Bacterial Agents; Brefeldin A; Cell Line; Centrifugation, Density Gradient; Connexin 43; Cyclopentanes; Endoplasmic Reticulum; Fibroblasts; Fluorescent Antibody Technique; Golgi Apparatus; Kidney; Macromolecular Substances; Methionine; Oocytes; Protein Processing, Post-Translational; Rats; RNA; Sulfur Radioisotopes; Xenopus | 1993 |
cAMP-dependent protein kinase modulates expression and subcellular localization of Dolichos biflorus agglutinin binding sites in renal epithelial cells.
Topics: 1-Methyl-3-isobutylxanthine; Acetylgalactosamine; Animals; Brefeldin A; Cell Compartmentation; Cell Line; Cell Membrane; Contact Inhibition; Cyclic AMP-Dependent Protein Kinases; Cyclopentanes; Enzyme Activation; Epithelial Cells; Epithelium; Glycoproteins; Golgi Apparatus; Intracellular Membranes; Kidney; Lectins; Plant Lectins; Receptors, Mitogen; Swine; Up-Regulation | 1993 |
Protein secretion from mouse skeletal muscle: coupling of increased exocytotic and endocytotic activities in denervated muscle.
Topics: Animals; Biological Transport, Active; Brefeldin A; Cyclopentanes; Dextrans; Endocytosis; Exocytosis; Fluorescein-5-isothiocyanate; L-Lactate Dehydrogenase; Male; Mice; Muscle Denervation; Muscle Proteins; Muscles; Temperature | 1993 |
Analysis of transport and targeting of syndecan-1: effect of cytoplasmic tail deletions.
Topics: Amino Acid Sequence; Animals; Base Sequence; Binding Sites; Biological Transport; Brefeldin A; CHO Cells; Conserved Sequence; Cricetinae; Cricetulus; Cyclopentanes; Cytoplasm; DNA; Dogs; Endoplasmic Reticulum; Golgi Apparatus; Membrane Glycoproteins; Mice; Molecular Sequence Data; Peptide Fragments; Protein Binding; Proteoglycans; Sequence Deletion; Syndecan-1; Syndecans; Transfection | 1994 |
Processing of major histocompatibility class I-restricted antigens in the endoplasmic reticulum.
Topics: Amino Acid Sequence; Animals; Antigen Presentation; ATP Binding Cassette Transporter, Subfamily B, Member 2; ATP Binding Cassette Transporter, Subfamily B, Member 3; ATP-Binding Cassette Transporters; Biological Transport; Brefeldin A; Cell Compartmentation; Chloroquine; Cyclopentanes; Endoplasmic Reticulum; H-2 Antigens; Hemagglutinin Glycoproteins, Influenza Virus; Hemagglutinins, Viral; Immunodominant Epitopes; L Cells; Mice; Mice, Inbred CBA; Molecular Sequence Data; Peptide Fragments; Tosyllysine Chloromethyl Ketone | 1995 |
Further analysis of the upregulation of bradykinin B1 receptors in isolated rabbit aorta by using metabolic inhibitors.
Topics: Animals; Aorta; Bradykinin; Brefeldin A; Cycloheximide; Cyclopentanes; In Vitro Techniques; Interleukin-1; Phenylalanine; Rabbits; Receptors, Bradykinin; Tunicamycin; Up-Regulation; Vasoconstriction | 1994 |
Distinct coated vesicles labeled for p200 bud from trans-Golgi network membranes.
Topics: Aluminum Compounds; Animals; Brefeldin A; Cell Line; Coated Pits, Cell-Membrane; Coatomer Protein; Cyclopentanes; Cytosol; Fluorescent Antibody Technique; Fluorides; Golgi Apparatus; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Insecta; Kidney; Liver; Membrane Proteins; Microscopy, Immunoelectron; Microtubule-Associated Proteins; Phosphoproteins; Protein Binding; Protein Synthesis Inhibitors; Rats | 1995 |
Brefeldin A renders Chinese hamster ovary cells insensitive to transcriptional suppression by 25-hydroxycholesterol.
Topics: Animals; Brefeldin A; Cell Line; CHO Cells; Cholesterol; Cricetinae; Cricetulus; Cyclopentanes; Dose-Response Relationship, Drug; Esterification; Gene Expression Regulation; Golgi Apparatus; Hydroxycholesterols; Marsupialia; Monensin; Protein Synthesis Inhibitors; RNA, Messenger; Transcription, Genetic | 1995 |
Chemical and thermal inhibition of protein secretion have stage specific effects on the intraerythrocytic development of Plasmodium falciparum in vitro.
Topics: Animals; Brefeldin A; Cyclopentanes; Dose-Response Relationship, Drug; Erythrocytes; Humans; Plasmodium falciparum; Protein Synthesis Inhibitors; Protozoan Proteins; Temperature | 1994 |
Isoprenoid lipid metabolism in the retina: dynamics of squalene and cholesterol incorporation and turnover in frog rod outer segment membranes.
Topics: Animals; Biological Transport, Active; Brefeldin A; Cholesterol; Chromatography, High Pressure Liquid; Cyclopentanes; Electrophoresis, Polyacrylamide Gel; Hot Temperature; In Vitro Techniques; Rana pipiens; Rod Cell Outer Segment; Rod Opsins; Squalene; Time Factors | 1995 |
Endoplasmic reticulum-mediated quality control of type I collagen production by cells from osteogenesis imperfecta patients with mutations in the pro alpha 1 (I) chain carboxyl-terminal propeptide which impair subunit assembly.
Topics: Base Sequence; Brefeldin A; Carrier Proteins; Cells, Cultured; Collagen; Cyclopentanes; Disulfides; DNA Primers; Endoplasmic Reticulum; Endoplasmic Reticulum Chaperone BiP; Fibroblasts; Heat-Shock Proteins; Humans; Infant, Newborn; Molecular Chaperones; Molecular Sequence Data; Mutation; Osteogenesis Imperfecta; Precipitin Tests; Procollagen; RNA, Messenger | 1995 |
Determination of the structural requirements for palmitoylation of p63.
Topics: Amino Acid Sequence; Animals; Base Sequence; Brefeldin A; Cell Line; Chlorocebus aethiops; Cyclopentanes; Cysteine; Membrane Proteins; Molecular Sequence Data; Palmitic Acid; Palmitic Acids | 1995 |
Autocrine motility factor receptor is a marker for a distinct membranous tubular organelle.
Topics: Animals; Antigens, CD; Biomarkers; Brefeldin A; Calcium-Binding Proteins; Calnexin; Cell Fractionation; Cell Line; Cell Membrane; Coatomer Protein; Cycloheximide; Cyclopentanes; Cytochalasin B; Endoplasmic Reticulum; Lysosomal Membrane Proteins; Membrane Glycoproteins; Membrane Proteins; Microsomes; Microtubule-Associated Proteins; Microtubules; Nocodazole; Organelles; Protein Synthesis Inhibitors; Receptors, Autocrine Motility Factor; Receptors, Cytokine; Receptors, Transferrin; Ubiquitin-Protein Ligases | 1995 |
Structural correlates of antifungal and cytotoxic activity of brefeldin A: the importance of a rigid planar lactone ring.
Topics: Animals; Antibiotics, Antineoplastic; Antifungal Agents; Brefeldin A; Cell Death; Cyclopentanes; Leukemia P388; Mice; Models, Molecular; Molecular Structure; Structure-Activity Relationship; Tumor Cells, Cultured | 1994 |
Cytotoxicity of brefeldin A correlates with its inhibitory effect on membrane binding of COP coat proteins.
Topics: 3T3 Cells; Adaptor Protein Complex gamma Subunits; Animals; Anti-Bacterial Agents; Brefeldin A; Cell Division; Cell Line; Cell Membrane; Cell Survival; Chlorocebus aethiops; CHO Cells; Coatomer Protein; Cricetinae; Cyclopentanes; Dose-Response Relationship, Drug; Humans; Kidney; Membrane Proteins; Mice; Microtubule-Associated Proteins; Rats; Tumor Cells, Cultured | 1995 |
Surface expression of the invariant chain (CD74) is independent of concomitant expression of major histocompatibility complex class II antigens.
Topics: Antigens, Differentiation, B-Lymphocyte; B-Lymphocytes; Biological Transport; Brefeldin A; Cell Line; Cell Membrane; Cyclopentanes; Electrophoresis, Gel, Two-Dimensional; Flow Cytometry; Golgi Apparatus; Histocompatibility Antigens Class II; HLA-D Antigens; HLA-DR Antigens; Humans; Receptors, Transferrin; Sialic Acids; T-Lymphocytes | 1995 |
Plasmodium falciparum-infected erythrocytes utilize a synthetic truncated ceramide precursor for synthesis and secretion of truncated sphingomyelin.
Topics: Animals; Brefeldin A; Cell Membrane Permeability; Ceramides; Cyclopentanes; Erythrocytes; Humans; In Vitro Techniques; Malaria, Falciparum; Plasmodium falciparum; Sphingomyelins; Transferases (Other Substituted Phosphate Groups) | 1995 |
The Golgi complex of Trypanosoma cruzi epimastigote forms.
Topics: Animals; Brefeldin A; Chlorocebus aethiops; Cyclopentanes; Golgi Apparatus; Microscopy, Electron; Trypanosoma cruzi; Vero Cells | 1995 |
Surface coat of sheep pulmonary intravascular macrophages is reconstituted following brefeldin A-mediated endocytosis.
Topics: Animals; Brefeldin A; Cyclopentanes; Endocytosis; Golgi Apparatus; Immunoenzyme Techniques; Lung; Macrophages, Alveolar; Membrane Proteins; Sheep | 1995 |
Truncated profibrillin of a Marfan patient is of apparent similar size as fibrillin: intracellular retention leads to over-N-glycosylation.
Topics: Actin Cytoskeleton; Amino Acid Sequence; Brefeldin A; Cells, Cultured; Cyclopentanes; Extracellular Matrix Proteins; Fibrillin-1; Fibrillins; Fibroblasts; Glycosylation; Humans; Marfan Syndrome; Microfilament Proteins; Molecular Sequence Data; Mutation; Protein Precursors; Protein Synthesis Inhibitors; Tunicamycin | 1995 |
Phospholipase D is present on Golgi-enriched membranes and its activation by ADP ribosylation factor is sensitive to brefeldin A.
Topics: ADP-Ribosylation Factors; Animals; Brefeldin A; Carrier Proteins; Cell Fractionation; Cell Line; CHO Cells; Cricetinae; Cyclopentanes; Dogs; Dose-Response Relationship, Drug; Enzyme Activation; Golgi Apparatus; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Intracellular Membranes; Kinetics; Orthomyxoviridae; Phospholipase D; Protein Binding; Protein Synthesis Inhibitors | 1995 |
Golgi apparatus is involved in intracellular Ca2+ regulation in epithelial LLC-PK1 cells.
Topics: Animals; Brefeldin A; Calcium; Cyclopentanes; Golgi Apparatus; Intracellular Membranes; LLC-PK1 Cells; Microscopy, Confocal; Subcellular Fractions; Swine; Vasopressins | 1995 |
A novel way to get out of the cell.
Topics: Animals; Biological Transport, Active; Biotechnology; Brefeldin A; Cell Line; Cyclopentanes; Dinitrophenols; Endoplasmic Reticulum; Golgi Apparatus; Humans; Protein Sorting Signals; Proteins | 1993 |
Cytosolic ADP-ribosylation factors are not required for endosome-endosome fusion but are necessary for GTP gamma S inhibition of fusion.
Topics: ADP-Ribosylation Factor 1; ADP-Ribosylation Factors; Animals; Brefeldin A; CHO Cells; Cricetinae; Cyclopentanes; Cytosol; Endosomes; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Intracellular Membranes; Membrane Fusion | 1995 |
Degradation of CD4 induced by human immunodeficiency virus type 1 Vpu protein: a predicted alpha-helix structure in the proximal cytoplasmic region of CD4 contributes to Vpu sensitivity.
Topics: Amino Acid Sequence; Animals; Antigens, CD; Base Sequence; Brefeldin A; CD4 Antigens; Cell Line; Chlorocebus aethiops; Cyclopentanes; DNA Primers; Endoplasmic Reticulum; Golgi Apparatus; HIV-1; Human Immunodeficiency Virus Proteins; Humans; Molecular Sequence Data; Polymerase Chain Reaction; Protein Processing, Post-Translational; Protein Structure, Secondary; Recombinant Proteins; Sequence Deletion; Substrate Specificity; Transfection; Viral Regulatory and Accessory Proteins | 1995 |
Glycosaminoglycan addition to proteoglycans by articular chondrocytes--evidence for core protein-specific pathways.
Topics: Aggrecans; Animals; Biological Transport; Brefeldin A; Carrier Proteins; Cartilage, Articular; Cattle; Cell Compartmentation; Cells, Cultured; Chondroitin Sulfates; Cyclopentanes; Decorin; Extracellular Matrix Proteins; Fibromodulin; Glycosaminoglycans; Golgi Apparatus; Hyaluronic Acid; Lectins, C-Type; Proteoglycans; Viral Core Proteins | 1995 |
A fluorescent lipid analogue can be used to monitor secretory activity and for isolation of mammalian secretion mutants.
Topics: Animals; Bacterial Proteins; Brefeldin A; Cell Membrane; Ceramides; CHO Cells; Cricetinae; Cyclopentanes; Cysteine; Drug Resistance; Flow Cytometry; Fluorescent Antibody Technique; Fluorescent Dyes; Genetic Complementation Test; Hemagglutinins, Viral; Kinetics; Methionine; Mutagenesis; Protein Biosynthesis; Protein Synthesis Inhibitors; Proteins; Streptolysins | 1995 |
Nocodazole-dependent transport, and brefeldin A--sensitive processing and sorting, of newly synthesized membrane proteins in cultured neurons.
Topics: Animals; Brefeldin A; Cells, Cultured; Cyclopentanes; Fetus; Fluorescent Antibody Technique; Gene Products, env; Golgi Apparatus; Hippocampus; Influenza A virus; Kinetics; Membrane Proteins; Methionine; Microscopy, Electron; Microtubules; Neurons; Nocodazole; Protein Processing, Post-Translational; Protein Synthesis Inhibitors; Rats; Rats, Sprague-Dawley; Semliki forest virus; Sulfur Radioisotopes; Vesicular stomatitis Indiana virus | 1995 |
Intracellular transport of inositol-containing sphingolipids in the yeast, Saccharomyces cerevisiae.
Topics: Biological Transport; Brefeldin A; Cell Membrane; Ceramides; Cycloheximide; Cyclopentanes; Endoplasmic Reticulum; Golgi Apparatus; Inositol; Nocodazole; Saccharomyces cerevisiae | 1995 |
Role of the endoplasmic reticulum chaperone calnexin in subunit folding and assembly of nicotinic acetylcholine receptors.
Topics: Animals; Brefeldin A; Calcium-Binding Proteins; Calnexin; Cells, Cultured; Chick Embryo; Cyclopentanes; Electrophoresis, Polyacrylamide Gel; Endoplasmic Reticulum; Kinetics; Macromolecular Substances; Mice; Models, Structural; Molecular Chaperones; Molecular Weight; Muscle, Skeletal; Protein Binding; Protein Folding; Protein Synthesis Inhibitors; Receptors, Nicotinic; Recombinant Proteins; Transfection | 1995 |
Effect of brefeldin A on ganglioside metabolism in cultured neurons: implications for the intracellular traffic of gangliosides.
Topics: Animals; Biological Transport; Brefeldin A; Carbohydrate Sequence; Cells, Cultured; Cyclopentanes; G(M1) Ganglioside; Glycosylation; Molecular Sequence Data; Neurons; Rats; Rats, Sprague-Dawley | 1994 |
Brefeldin A inhibits insulin-dependent receptor redistribution in HIRcB cells.
Topics: Animals; Brefeldin A; Cell Line; Cell Membrane; Cyclopentanes; Dose-Response Relationship, Drug; Enzyme Activation; Humans; Insulin; Insulin Antagonists; Phosphorylation; Protein Kinases; Rats; Receptor, Insulin; Recombinant Proteins; Signal Transduction | 1995 |
A phagosome-to-cytosol pathway for exogenous antigens presented on MHC class I molecules.
Topics: Amino Acid Sequence; Animals; Antigen Presentation; Antigens; ATP Binding Cassette Transporter, Subfamily B, Member 2; ATP Binding Cassette Transporter, Subfamily B, Member 3; ATP-Binding Cassette Transporters; Brefeldin A; Cell Line; Chloroquine; Cyclopentanes; Cysteine Endopeptidases; Cytosol; Histocompatibility Antigens Class I; Macrophages; Mice; Molecular Sequence Data; Multienzyme Complexes; Oligopeptides; Ovalbumin; Phagocytosis; Phagosomes; Plant Proteins; Proteasome Endopeptidase Complex; Ribosome Inactivating Proteins, Type 1 | 1995 |
The effect of sterols and brefeldin A on protein degradation in UT-1 cells.
Topics: Animals; Brefeldin A; Cell Line; CHO Cells; Cricetinae; Cyclopentanes; Endoplasmic Reticulum; Golgi Apparatus; Hydroxymethylglutaryl CoA Reductases; Mannosidases; Protein Synthesis Inhibitors; Sterols | 1995 |
Acquisition of peptides by MHC class II polypeptides in the absence of the invariant chain.
Topics: Amino Acid Sequence; Animals; Antigen Presentation; Antigens, Differentiation, B-Lymphocyte; Brefeldin A; Cell Line; Chloroquine; Cyclopentanes; Electrophoresis, Gel, Two-Dimensional; Electrophoresis, Polyacrylamide Gel; Flow Cytometry; Histocompatibility Antigens Class II; HLA-DR Antigens; Humans; Leupeptins; Molecular Sequence Data; Peptides; Precipitin Tests; Protein Binding; Rats; Sodium Dodecyl Sulfate; Transfection; Tumor Cells, Cultured | 1995 |
Brefeldin A down-regulates the transferrin receptor in K562 cells.
Topics: Brefeldin A; Cell Membrane; Cyclopentanes; Down-Regulation; Endocytosis; Exocytosis; Humans; Kinetics; Leukemia, Erythroblastic, Acute; Neoplasm Proteins; Receptors, Transferrin; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1994 |
Effect of Brefeldin A on transcytotic vesicular pathway and bile secretion: a study on the isolated perfused rat liver and isolated rat hepatocyte couplets.
Topics: Animals; Bile; Biological Transport, Active; Brefeldin A; Cells, Cultured; Cyclopentanes; Horseradish Peroxidase; In Vitro Techniques; Intercellular Junctions; Liver; Male; Microscopy, Electron; Protein Synthesis Inhibitors; Rats; Rats, Sprague-Dawley; Taurocholic Acid | 1995 |
Brefeldin A inhibits vaccinia virus envelopment but does not prevent normal processing and localization of the putative envelopment receptor P37.
Topics: Antifungal Agents; Antiviral Agents; Brefeldin A; Cyclopentanes; Membrane Proteins; Protein Processing, Post-Translational; Receptors, Virus; Vaccinia virus; Viral Envelope Proteins | 1995 |
Murine mammary-derived cells secrete the N-terminal 41% of human apolipoprotein B on high density lipoprotein-sized lipoproteins containing a triacylglycerol-rich core.
Topics: Animals; Apolipoproteins B; Base Sequence; Brefeldin A; Carrier Proteins; Cholesterol Ester Transfer Proteins; Cholesterol Esters; Cyclopentanes; Glycoproteins; Golgi Apparatus; Humans; Lipoproteins, HDL; Mammary Neoplasms, Animal; Mice; Molecular Sequence Data; Monensin; Oleic Acid; Oleic Acids; Phospholipids; Protein Synthesis Inhibitors; Triglycerides; Tumor Cells, Cultured | 1995 |
Quantitative export of FGF-2 occurs through an alternative, energy-dependent, non-ER/Golgi pathway.
Topics: Amino Acid Sequence; Animals; Base Sequence; Biological Transport, Active; Brefeldin A; Cells, Cultured; Chlorocebus aethiops; Cyclopentanes; DNA Primers; Endoplasmic Reticulum; Fibroblast Growth Factor 2; Golgi Apparatus; Humans; Kanamycin Kinase; Membrane Glycoproteins; Molecular Sequence Data; Molecular Weight; Phosphotransferases (Alcohol Group Acceptor); Recombinant Fusion Proteins; Recombinant Proteins; Transfection; Viral Envelope Proteins | 1995 |
Secretion of Alzheimer beta/A4 protein (1-40) and intracellular retention of beta/A4 protein (1-42) in transfected COS cells.
Topics: Amino Acid Sequence; Amyloid beta-Peptides; Animals; Base Sequence; Brefeldin A; Cell Line; Culture Media, Conditioned; Cyclopentanes; DNA, Complementary; Gene Expression; Methylamines; Molecular Sequence Data; Mutagenesis; Protease Inhibitors; Protein Sorting Signals; Rats; Structure-Activity Relationship; Transfection | 1995 |
Pertussis toxin-mediated ADP-ribosylation of target proteins in Chinese hamster ovary cells involves a vesicle trafficking mechanism.
Topics: Adenosine Diphosphate Ribose; Ammonium Chloride; Animals; Biological Transport; Brefeldin A; Cell Compartmentation; CHO Cells; Cricetinae; Cyclopentanes; Detergents; GTP-Binding Proteins; Intracellular Membranes; Models, Biological; Pertussis Toxin; Protein Processing, Post-Translational; Protein Synthesis Inhibitors; Subcellular Fractions; Virulence Factors, Bordetella | 1995 |
Ceramide reverses brefeldin A (BFA) resistance in BFA-resistant cell lines.
Topics: Animals; Antifungal Agents; Brefeldin A; Cell Line; Cell Survival; Ceramides; Chlorocebus aethiops; Cyclopentanes; Dogs; Drug Resistance; Ricin; Sphingolipids; Vero Cells | 1995 |
Independent signaling of grp78 gene transcription and phosphorylation of eukaryotic initiator factor 2 alpha by the stressed endoplasmic reticulum.
Topics: Brefeldin A; Carrier Proteins; Cell Line; Cycloheximide; Cyclopentanes; Dithiothreitol; Endoplasmic Reticulum; Endoplasmic Reticulum Chaperone BiP; Eukaryotic Initiation Factor-2; Heat-Shock Proteins; Ionomycin; Molecular Chaperones; Phosphorylation; RNA, Messenger; Signal Transduction; Transcription, Genetic | 1995 |
Developmental induction of Golgi structure and function in the primitive eukaryote Giardia lamblia.
Topics: 4-Chloro-7-nitrobenzofurazan; Acid Phosphatase; ADP-Ribosylation Factors; Alkaline Phosphatase; Animals; Biological Transport; Brefeldin A; Ceramides; Coatomer Protein; Cyclopentanes; Giardia lamblia; Golgi Apparatus; GTP-Binding Proteins; Malate Dehydrogenase; Microtubule-Associated Proteins; Protein Processing, Post-Translational; Protozoan Proteins | 1995 |
Inhibition of Shiga-like toxins by brefeldin A.
Topics: Anti-Bacterial Agents; Bacterial Toxins; Brefeldin A; Cyclopentanes; Enterotoxins; Golgi Apparatus; HeLa Cells; Humans; Shiga Toxin 1; Shiga Toxin 2 | 1995 |
Effects of brefeldin A on the three-dimensional structure of the Golgi apparatus in a sensitive strain of Saccharomyces cerevisiae.
Topics: ADP-Ribosylation Factor 1; ADP-Ribosylation Factors; Brefeldin A; Cyclopentanes; Endoplasmic Reticulum; Genes, Bacterial; Golgi Apparatus; GTP-Binding Proteins; Microscopy, Electron; Mutation; Saccharomyces cerevisiae | 1995 |
bfr1+, a novel gene of Schizosaccharomyces pombe which confers brefeldin A resistance, is structurally related to the ATP-binding cassette superfamily.
Topics: Adenosine Triphosphate; Amino Acid Sequence; ATP-Binding Cassette Transporters; Base Sequence; Binding Sites; Brefeldin A; Cloning, Molecular; Cyclopentanes; Drug Resistance, Microbial; Drug Resistance, Multiple; Fungal Proteins; Genes, Fungal; Molecular Sequence Data; Mutagenesis; Phenotype; Restriction Mapping; Schizosaccharomyces; Schizosaccharomyces pombe Proteins; Sequence Analysis, DNA; Sequence Homology, Amino Acid | 1995 |
Monensin and brefeldin A inhibit high density lipoprotein-mediated cholesterol efflux from cholesterol-enriched cells. Implications for intracellular cholesterol transport.
Topics: Ammonium Chloride; Animals; Aorta, Abdominal; Biological Transport; Brefeldin A; Cells, Cultured; Chloroquine; Cholesterol; Cyclopentanes; Dose-Response Relationship, Drug; Fibroblasts; Humans; Kinetics; Lipoproteins, HDL; Lipoproteins, LDL; Male; Models, Biological; Monensin; Muscle, Smooth, Vascular; Nigericin; Protein Synthesis Inhibitors; Skin; Sterols; Swine | 1995 |
Heat-inactivated Sendai virus can enter multiple MHC class I processing pathways and generate cytotoxic T lymphocyte responses in vivo.
Topics: Amino Acid Sequence; Animals; Antiviral Agents; ATP Binding Cassette Transporter, Subfamily B, Member 2; ATP-Binding Cassette Transporters; Brefeldin A; Cyclopentanes; Cytotoxicity Tests, Immunologic; Female; Flow Cytometry; H-2 Antigens; HN Protein; Hot Temperature; Mice; Mice, Inbred C57BL; Molecular Sequence Data; Parainfluenza Virus 1, Human; T-Lymphocytes, Cytotoxic; Viral Fusion Proteins | 1995 |
Brefeldin A affects West Nile virus replication in Vero cells but not C6/36 cells.
Topics: Animals; Antiviral Agents; Biological Transport; Brefeldin A; Cell Line; Culicidae; Cyclopentanes; Glycoproteins; Vero Cells; Viral Proteins; Virus Replication; West Nile virus | 1993 |
Golgi retardation in Madin-Darby canine kidney and Chinese hamster ovary cells of a transmembrane chimera of two surface proteins.
Topics: Amino Acid Sequence; Aminopeptidases; Animals; Base Sequence; Brefeldin A; CD13 Antigens; Cell Line; Cell Membrane; CHO Cells; Chromatography, Affinity; Cricetinae; Cyclopentanes; Dipeptidyl Peptidase 4; Dipeptidyl-Peptidases and Tripeptidyl-Peptidases; DNA Primers; Dogs; Electrophoresis, Polyacrylamide Gel; Endoplasmic Reticulum; Fluorescent Antibody Technique; Golgi Apparatus; Kidney; Kinetics; Lectins; Membrane Proteins; Molecular Sequence Data; Polymerase Chain Reaction; Protein Synthesis Inhibitors; Recombinant Fusion Proteins; Subcellular Fractions | 1994 |
Basolateral to apical transcytosis in polarized cells is indirect and involves BFA and trimeric G protein sensitive passage through the apical endosome.
Topics: Animals; Biological Transport; Brefeldin A; Cell Line; Cell Membrane; Cell Polarity; Cholera Toxin; Cyclopentanes; Dogs; Endocytosis; Endosomes; Epithelium; Exocytosis; GTP-Binding Proteins; Ligands; Microscopy, Fluorescence; Microtubules; Receptors, Fc; Ricin | 1994 |
Processing of urushiol (poison ivy) hapten by both endogenous and exogenous pathways for presentation to T cells in vitro.
Topics: Anti-Bacterial Agents; Antigen Presentation; Antigen-Presenting Cells; Azides; Brefeldin A; Catechols; CD4-Positive T-Lymphocytes; CD8 Antigens; Cell Line; Cyclopentanes; Dose-Response Relationship, Drug; Haptens; Humans; Intracellular Membranes; Lymphocyte Activation; Monensin; Plants, Toxic; T-Lymphocyte Subsets; Tetanus Toxoid | 1994 |
Modification by brefeldin A, bafilomycin A1 and 7-chloro-4-nitrobenz-2-oxa-1,3-diazole (NBD) of cellular accumulation and intracellular distribution of anthracyclines in the non-P-glycoprotein-mediated multidrug-resistant cell line COR-L23/R.
Topics: 4-Chloro-7-nitrobenzofurazan; Anti-Bacterial Agents; Antibiotics, Antineoplastic; ATP Binding Cassette Transporter, Subfamily B, Member 1; Brefeldin A; Carcinoma, Non-Small-Cell Lung; Carrier Proteins; Cell Nucleus; Cyclopentanes; Cytoplasm; Daunorubicin; Doxorubicin; Drug Interactions; Drug Resistance; Drug Screening Assays, Antitumor; Golgi Apparatus; Humans; Lung Neoplasms; Macrolides; Membrane Glycoproteins; Protein Synthesis Inhibitors; Proton-Translocating ATPases; Tetrazolium Salts; Thiazoles; Tumor Cells, Cultured | 1994 |
Sequential interaction of the chaperones BiP and GRP94 with immunoglobulin chains in the endoplasmic reticulum.
Topics: Brefeldin A; Carrier Proteins; Chaperonins; Cyclopentanes; Endoplasmic Reticulum; Endoplasmic Reticulum Chaperone BiP; Heat-Shock Proteins; HSP70 Heat-Shock Proteins; Immunoglobulin Light Chains; Membrane Proteins; Molecular Chaperones; Protein Binding; Proteins; Tumor Cells, Cultured | 1994 |
Maintenance of membrane sheets by cultured oligodendrocytes requires continuous microtubule turnover and Golgi transport.
Topics: Animals; Biological Transport; Biopolymers; Brefeldin A; Cells, Cultured; Cyclopentanes; Golgi Apparatus; Membranes; Mice; Microtubules; Oligodendroglia; Paclitaxel; Tubulin | 1994 |
Polarity of processes with Golgi apparatus in a subpopulation of type I astrocytes.
Topics: Animals; Antibodies, Monoclonal; Astrocytes; Brefeldin A; Cells, Cultured; Cyclopentanes; Cytoskeleton; Endoplasmic Reticulum; Fluorescent Antibody Technique; Glial Fibrillary Acidic Protein; Golgi Apparatus; Immunohistochemistry; Microscopy, Electron; Protein Synthesis Inhibitors; Rats; Spinal Cord | 1994 |
Complete Golgi passage of glycotripeptides generated in the endoplasmic reticulum of mammalian cells.
Topics: Animals; Brefeldin A; Carbohydrate Sequence; CHO Cells; Cricetinae; Cyclopentanes; Endoplasmic Reticulum; Glycopeptides; Glycosylation; Golgi Apparatus; Hexosaminidases; Liver; Male; Molecular Sequence Data; Oligopeptides; Perfusion; Protein Synthesis Inhibitors; Rats; Rats, Wistar | 1994 |
Brefeldin A sensitivity and resistance in Schizosaccharomyces pombe. Isolation of multiple genes conferring resistance.
Topics: Amino Acid Sequence; Antifungal Agents; Brefeldin A; Cyclopentanes; Drug Resistance, Microbial; Exportin 1 Protein; Fungal Proteins; Golgi Apparatus; Karyopherins; Molecular Sequence Data; Mutation; Pancreatitis-Associated Proteins; Phenotype; Plasmids; Receptors, Cytoplasmic and Nuclear; Saccharomyces cerevisiae; Schizosaccharomyces; Sequence Homology, Amino Acid | 1994 |
Fluorescent choleretic and cholestatic bile salts take different paths across the hepatocyte: transcytosis of glycolithocholate leads to an extensive redistribution of annexin II.
Topics: Actins; Animals; Annexin A2; Bile Acids and Salts; Biological Transport; Brefeldin A; Cholic Acids; Colchicine; Cyclopentanes; Fluoresceins; Glycocholic Acid; Lithocholic Acid; Liver; Male; Microtubules; Rats; Rats, Wistar; Vacuoles | 1994 |
Seminiferous tubule fluid secretion is a Sertoli cell microtubule-dependent process inhibited by 2,5-hexanedione exposure.
Topics: Analysis of Variance; Animals; Brefeldin A; Colchicine; Cyclopentanes; Hexanones; Kinetics; Male; Microtubules; Protein Synthesis Inhibitors; Rats; Rats, Sprague-Dawley; Seminiferous Tubules; Sertoli Cells | 1994 |
Inhibition of procollagen I degradation by colligin: a collagen-binding serpin.
Topics: Amino Acid Sequence; Animals; Biological Transport; Brefeldin A; Carrier Proteins; Cell Line; Cyclopentanes; Endoplasmic Reticulum; Fibroblasts; Fibronectins; Glycoproteins; Humans; Hydrogen-Ion Concentration; Leupeptins; Microsomes, Liver; Molecular Sequence Data; Procollagen; Protease Inhibitors; Rats; Tosyllysine Chloromethyl Ketone; Tosylphenylalanyl Chloromethyl Ketone | 1994 |
Plasmodium yoelii: brefeldin A-sensitive processing of proteins targeted to the rhoptries.
Topics: Animals; Antibodies, Monoclonal; Blotting, Western; Brefeldin A; Cyclopentanes; Electrophoresis, Polyacrylamide Gel; Female; Immune Sera; Mice; Mice, Inbred BALB C; Plasmodium yoelii; Precipitin Tests; Protein Synthesis Inhibitors; Protozoan Proteins | 1994 |
Plasmodium falciparum: the Pf332 antigen is secreted from the parasite by a brefeldin A-dependent pathway and is translocated to the erythrocyte membrane via the Maurer's clefts.
Topics: Animals; Antibodies, Monoclonal; Antigens, Protozoan; Blotting, Western; Brefeldin A; Cyclopentanes; Cytoplasm; Enzyme-Linked Immunosorbent Assay; Erythrocyte Membrane; Erythrocytes; Fluorescent Antibody Technique; Humans; Immune Sera; Microscopy, Confocal; Microscopy, Immunoelectron; Plasmodium falciparum; Protein Synthesis Inhibitors; Protozoan Proteins; Recombinant Proteins | 1994 |
Thiol-reducing agents and calcium perturbants alter intracellular sorting of immunoglobulin M.
Topics: Animals; Brefeldin A; Calcimycin; Calcium; Cell Compartmentation; Cell Line; Cyclopentanes; Endoplasmic Reticulum; Immunoglobulin M; Macromolecular Substances; Mercaptoethanol; Mice; Oxidation-Reduction; Protein Processing, Post-Translational; Receptors, Antigen, B-Cell; Sulfhydryl Compounds; Terpenes; Thapsigargin | 1994 |
LDLC encodes a brefeldin A-sensitive, peripheral Golgi protein required for normal Golgi function.
Topics: Adaptor Proteins, Vesicular Transport; Amino Acid Sequence; Animals; Base Sequence; Blotting, Northern; Brefeldin A; Caenorhabditis elegans; Caenorhabditis elegans Proteins; CHO Cells; Clone Cells; Cloning, Molecular; Cricetinae; Cyclopentanes; DNA Primers; DNA, Complementary; Gene Library; Golgi Apparatus; Humans; Molecular Sequence Data; Polymerase Chain Reaction; Protein Biosynthesis; Protein Synthesis Inhibitors; Proteins; Sequence Homology, Amino Acid; Transcription Factors; Transfection | 1994 |
Transport via the regulated secretory pathway in semi-intact PC12 cells: role of intra-cisternal calcium and pH in the transport and sorting of secretogranin II.
Topics: Adenosine Triphosphate; Ammonium Chloride; Animals; Brefeldin A; Calcimycin; Calcium; Cell Membrane; Chromogranins; Cyclopentanes; Cytosol; Exocytosis; Golgi Apparatus; Guanosine 5'-O-(3-Thiotriphosphate); Hydrogen-Ion Concentration; Kinetics; Membrane Fusion; Nigericin; Organelles; PC12 Cells; Pituitary Neoplasms; Pro-Opiomelanocortin; Protein Processing, Post-Translational; Protein Synthesis Inhibitors; Proteins; Rats; Tumor Cells, Cultured | 1994 |
Kinesin-mediated organelle translocation revealed by specific cellular manipulations.
Topics: Actin Cytoskeleton; Animals; Base Sequence; Brefeldin A; Carbocyanines; Cells, Cultured; Cyclopentanes; Endocytosis; Fluorescent Dyes; Golgi Apparatus; Hippocampus; Kinesins; Microtubules; Mitochondria; Molecular Sequence Data; Neurites; Oligonucleotides, Antisense; Organelles; Protein Synthesis Inhibitors; Pyramidal Cells; Rhodamine 123; Rhodamines | 1994 |
Caveolin moves from caveolae to the Golgi apparatus in response to cholesterol oxidation.
Topics: Biological Transport; Brefeldin A; Caveolin 1; Caveolins; Cell Membrane; Cells, Cultured; Cholesterol; Cholesterol Oxidase; Cyclopentanes; Endoplasmic Reticulum; Fibroblasts; Fluorescent Antibody Technique; Golgi Apparatus; Humans; Immunohistochemistry; Membrane Proteins; Oxidation-Reduction; Temperature | 1994 |
Phagocytic processing of exogenous particulate antigens by macrophages for presentation by class I MHC molecules.
Topics: Animals; Antigen Presentation; Brefeldin A; CD8-Positive T-Lymphocytes; Cyclopentanes; Histocompatibility Antigens Class I; Macrophages; Mice; Mice, Inbred C57BL; Mice, Inbred CBA; Ovalbumin; Peptides; Polystyrenes; Protein Synthesis Inhibitors; Salmonella typhimurium | 1994 |
Infection with Listeria monocytogenes impairs sialic acid addition to host cell glycoproteins.
Topics: Animals; Brefeldin A; Cell Line; Cyclopentanes; Electrophoresis, Gel, Two-Dimensional; Glycoproteins; Glycoside Hydrolases; Glycosylation; Histocompatibility Antigens Class I; Interferon-gamma; Kinetics; Lipopolysaccharides; Listeria monocytogenes; Macrophages; Membrane Glycoproteins; Mice; Mice, Inbred BALB C; N-Acetylneuraminic Acid; Neuraminidase; Protein Synthesis Inhibitors; Sialic Acids | 1994 |
Biogenesis of the hepatitis B viral middle (M) surface protein in a human hepatoma cell line: demonstration of an alternative secretion pathway.
Topics: Autoradiography; Base Sequence; Brefeldin A; Carcinoma, Hepatocellular; Cell Line; Codon; Cyclopentanes; Electrophoresis, Polyacrylamide Gel; Endoplasmic Reticulum; Glycosylation; Hepatitis B; Hepatitis B virus; Humans; Kinetics; Liver Neoplasms; Methionine; Mutagenesis; Protein Biosynthesis; Protein Synthesis Inhibitors; RNA, Viral; Sulfur Radioisotopes; Transfection; Tumor Cells, Cultured; Viral Envelope Proteins; Virion | 1994 |
Receptor-mediated peptide delivery in pulmonary epithelial monolayers.
Topics: Animals; Brefeldin A; Cells, Cultured; Cyclopentanes; Endocytosis; Epithelial Cells; Epithelium; Horseradish Peroxidase; Immunoconjugates; Lung; Male; Peptides; Protein Synthesis Inhibitors; Pulmonary Alveoli; Rats; Rats, Sprague-Dawley; Receptors, Cell Surface; Transferrin | 1994 |
Inhibition by Brefeldin A of the envelopment of nucleocapsids in herpes simplex virus type 1-infected Vero cells.
Topics: Animals; Antiviral Agents; Brefeldin A; Capsid; Chlorocebus aethiops; Cyclopentanes; Dose-Response Relationship, Drug; Herpesvirus 1, Human; Kinetics; Methionine; Protein Synthesis Inhibitors; Sulfur Radioisotopes; Time Factors; Vero Cells; Viral Core Proteins; Viral Envelope Proteins; Virus Replication | 1994 |
Hydrolysis of cell surface inositol phospholipid leads to the delayed stimulation of phosphatidylinositol synthesis in bovine aortic endothelial cells.
Topics: Animals; Brefeldin A; Cattle; Cell Membrane; Cells, Cultured; Cyclopentanes; Endothelium, Vascular; Hydrolysis; Phosphatidylcholines; Phosphatidylinositol Diacylglycerol-Lyase; Phosphatidylinositols; Phosphoric Diester Hydrolases; Propranolol; Type C Phospholipases | 1994 |
Endocytosis and recycling of gangliosides in a human melanoma cell line: inhibitory effect of brefeldin A and monensin.
Topics: Antibodies, Monoclonal; Antibody Specificity; Brefeldin A; Carbohydrate Sequence; Cyclopentanes; Endocytosis; Gangliosides; Golgi Apparatus; Humans; In Vitro Techniques; Melanoma; Molecular Sequence Data; Monensin; Tumor Cells, Cultured | 1994 |
Rapid cleavage of the endogenous PC3 prosegment and slow conversion to 74 kDa and 66 kDa proteins in AtT-20 cells.
Topics: Amino Acid Sequence; Aspartic Acid Endopeptidases; Brefeldin A; Cell Line; Cyclopentanes; Dithiothreitol; Hexosaminidases; Kinetics; Molecular Sequence Data; Molecular Weight; Monensin; Precipitin Tests; Proprotein Convertases; Protein Processing, Post-Translational; Time Factors; Tunicamycin | 1994 |
Polarized distribution of the trans-Golgi network marker TGN38 during the in vitro development of neocortical neurons: effects of nocodazole and brefeldin A.
Topics: Animals; Brefeldin A; Cell Polarity; Cells, Cultured; Cellular Senescence; Cerebral Cortex; Cyclopentanes; Glycoproteins; Immunohistochemistry; Membrane Glycoproteins; Membrane Proteins; Microscopy, Fluorescence; Neurons; Nocodazole; Rats; Tissue Distribution | 1994 |
Mechanism and subcellular localization of secretory IgM polymer assembly.
Topics: Animals; Biological Transport; Brefeldin A; Cell Compartmentation; Cyclopentanes; Disulfides; Endoplasmic Reticulum; Golgi Apparatus; Hexosaminidases; Hybridomas; Immunoglobulin A, Secretory; Immunoglobulin J-Chains; In Vitro Techniques; Macromolecular Substances; Mice; Polymers; Protein Processing, Post-Translational; Temperature | 1994 |
A hypothesis on the traffic of MG160, a medial Golgi sialoglycoprotein, from the trans-Golgi network to the Golgi cisternae.
Topics: Animals; Biological Transport; Brefeldin A; Cyclopentanes; Golgi Apparatus; PC12 Cells; Protein Processing, Post-Translational; Receptors, Cell Surface; Receptors, Fibroblast Growth Factor; Sialoglycoproteins | 1994 |
Brefeldin A inhibits transport of the glycophorin-binding protein from Plasmodium falciparum into the host erythrocyte.
Topics: Animals; Biological Transport; Brefeldin A; Cell Compartmentation; Cell Nucleus; Cyclopentanes; Cytoplasm; Erythrocytes; Humans; In Vitro Techniques; Plasmodium falciparum; Protozoan Proteins; Saponins | 1994 |
Inhibition by brefeldin A of NADH oxidation activity of rat liver Golgi apparatus accelerated by GDP.
Topics: Animals; Brefeldin A; Cyclopentanes; Golgi Apparatus; Guanosine Diphosphate; Liver; Male; Multienzyme Complexes; NAD; NADH, NADPH Oxidoreductases; Oxidation-Reduction; Rats | 1994 |
Presentation of an exogenous antigen by major histocompatibility complex class I molecules.
Topics: ADP Ribose Transferases; Antigen Presentation; Bacterial Toxins; Brefeldin A; Cells, Cultured; Cyclopentanes; Cytotoxicity Tests, Immunologic; Exotoxins; Fluorescent Antibody Technique; HLA-A2 Antigen; Humans; Pseudomonas aeruginosa Exotoxin A; Recombinant Fusion Proteins; T-Lymphocytes, Cytotoxic; Viral Matrix Proteins; Virulence Factors | 1994 |
Isolation and characterization of mutant CHO cell lines with compartment-specific resistance to brefeldin A.
Topics: ADP-Ribosylation Factors; Animals; Brefeldin A; Cell Compartmentation; Cell Division; CHO Cells; Coatomer Protein; Cricetinae; Cyclopentanes; Dose-Response Relationship, Drug; Drug Resistance; Golgi Apparatus; GTP-Binding Proteins; Membrane Glycoproteins; Membrane Proteins; Microtubule-Associated Proteins; Models, Biological; Mutation; Organelles; Phenotype; Selection, Genetic; Viral Envelope Proteins | 1994 |
Secretory pathway function, but not cytoskeletal integrity, is required in poliovirus infection.
Topics: Animals; Antigens, Viral; Antiviral Agents; Biological Transport; Brefeldin A; Cells, Cultured; Cyclopentanes; Cytochalasin D; Fluorescent Antibody Technique; Golgi Apparatus; Humans; Intermediate Filaments; Nocodazole; Poliovirus; Species Specificity; Virus Replication | 1994 |
Discrimination between temperature- and brefeldin A-sensitive steps in the sulfation, phosphorylation, and cleavage of progastrin and its derivatives.
Topics: Amides; Animals; Brefeldin A; Chromatography, High Pressure Liquid; Cyclopentanes; Gastrins; Hot Temperature; Hydrolysis; Immunohistochemistry; Microscopy, Immunoelectron; Phosphorylation; Protein Precursors; Radioimmunoassay; Rats; Sulfates | 1994 |
Presentation of viral antigens restricted by H-2Kb, Db or Kd in proteasome subunit LMP2- and LMP7-deficient cells.
Topics: Animals; Antigen Presentation; Antigens, Viral; Brefeldin A; Cell Line; Cyclopentanes; Cysteine Endopeptidases; Cytotoxicity Tests, Immunologic; Female; Flow Cytometry; H-2 Antigens; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Multienzyme Complexes; Orthomyxoviridae; Proteasome Endopeptidase Complex; Proteins; T-Lymphocytes, Cytotoxic; Transfection; Vesicular stomatitis Indiana virus | 1994 |
Brefeldin A causes structural and functional alterations of the trans-Golgi network of MDCK cells.
Topics: Adaptor Protein Complex gamma Subunits; Animals; Biomarkers; Brefeldin A; Cell Line; Cell Polarity; Cyclopentanes; Dogs; Epithelial Cells; Golgi Apparatus; GTP-Binding Proteins; Hemagglutinin Glycoproteins, Influenza Virus; Hemagglutinins, Viral; Intracellular Membranes; Kidney; Proteins; Recombinant Fusion Proteins | 1994 |
Brefeldin A inhibits protein synthesis through the phosphorylation of the alpha-subunit of eukaryotic initiation factor-2.
Topics: Animals; Blotting, Western; Brefeldin A; Cyclopentanes; Electrophoresis, Polyacrylamide Gel; Eukaryotic Initiation Factor-2; Peptide Chain Initiation, Translational; Phosphorylation; Protein Synthesis Inhibitors; Rats; Tumor Cells, Cultured | 1994 |
Formation of the insulin-containing secretory granule core occurs within immature beta-granules.
Topics: Animals; Biological Transport; Brefeldin A; Cyclopentanes; Cytoplasmic Granules; Golgi Apparatus; Humans; Insulin; Islets of Langerhans; Mice; Proinsulin | 1994 |
Association of Ld-restricted peptides with the wild-derived mouse Lw16 MHC class I molecule.
Topics: Amino Acid Sequence; Animals; Antibodies, Monoclonal; Blood; Brefeldin A; Cell Membrane; Cyclopentanes; Cytomegalovirus; Histocompatibility Antigens; Histocompatibility Antigens Class I; Immediate-Early Proteins; L Cells; Lymphocytic choriomeningitis virus; Mice; Molecular Sequence Data; Nucleoproteins; Peptides; Viral Proteins | 1994 |
The establishment of polarity and enhanced transcytosis of transferrin receptors in enterocyte-like Caco-2 cells.
Topics: Alkaline Phosphatase; Brefeldin A; Carcinoma; Colonic Neoplasms; Cyclopentanes; Horseradish Peroxidase; Humans; Intestinal Mucosa; Intestines; Iodine Radioisotopes; Microvilli; Receptors, Transferrin; Tumor Cells, Cultured | 1994 |
BFR1, a multicopy suppressor of brefeldin A-induced lethality, is implicated in secretion and nuclear segregation in Saccharomyces cerevisiae.
Topics: Amino Acid Sequence; Animals; Base Sequence; Brefeldin A; Cell Nucleus; Cloning, Molecular; Cyclopentanes; Endoplasmic Reticulum; Fungal Proteins; Gene Expression; Genes, Fungal; Genotype; Golgi Apparatus; Mammals; Molecular Sequence Data; Mutation; Plasmids; Repressor Proteins; Restriction Mapping; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Suppression, Genetic | 1994 |
Differential effects of brefeldin A on chondroitin sulfate and hyaluronan synthesis in rat chondrosarcoma cells.
Topics: Animals; Brefeldin A; Chondroitin Sulfates; Chondrosarcoma; Cycloheximide; Cyclopentanes; Glucosamine; Glycosides; Golgi Apparatus; Hyaluronic Acid; Kinetics; Male; Protein Synthesis Inhibitors; Proteoglycans; Rats; Rats, Sprague-Dawley; Sulfates; Time Factors; Tumor Cells, Cultured | 1994 |
Effects of brefeldin A on aggrecan core protein synthesis and maturation in rat chondrosarcoma cells.
Topics: Aggrecans; Amino Acid Sequence; Animals; Brefeldin A; Chondroitin Sulfate Proteoglycans; Chondrosarcoma; Cyclopentanes; Electrophoresis, Polyacrylamide Gel; Extracellular Matrix Proteins; Golgi Apparatus; Kinetics; Lectins, C-Type; Male; Molecular Sequence Data; Molecular Weight; Protein Precursors; Protein Synthesis Inhibitors; Proteoglycans; Rats; Rats, Sprague-Dawley; Tumor Cells, Cultured | 1994 |
Secretion of TNF from a rat mast cell line is a brefeldin A-sensitive and a calcium/protein kinase C-regulated process.
Topics: Animals; beta-N-Acetylhexosaminidases; Brefeldin A; Calcium; Cell Line; Cyclopentanes; Cytoplasmic Granules; Golgi Apparatus; Mast Cells; Protein Kinase C; Rats; Receptors, IgE; Receptors, Muscarinic; Tumor Necrosis Factor-alpha | 1994 |
Action of brefeldin A on translation in Semliki Forest virus-infected HeLa cells and cells doubly infected with poliovirus.
Topics: Blotting, Northern; Brefeldin A; Cyclopentanes; DNA Replication; DNA, Viral; Electrophoresis, Polyacrylamide Gel; HeLa Cells; Humans; Immunoblotting; Kinetics; Poliovirus; Protein Biosynthesis; Protein Synthesis Inhibitors; RNA, Messenger; RNA, Viral; Semliki forest virus; Viral Proteins | 1994 |
Brefeldin A induced dose-dependent changes to Golgi structure and function in the rat exocrine pancreas.
Topics: Animals; Brefeldin A; Clathrin; Coatomer Protein; Cyclopentanes; Dose-Response Relationship, Drug; Endoplasmic Reticulum; Esters; Exocytosis; Gabexate; Golgi Apparatus; Guanidines; Male; Membrane Fusion; Microtubule-Associated Proteins; Pancreas; Pancreatic Juice; Protease Inhibitors; Rats; Rats, Wistar | 1994 |
Overexpression of TGN38/41 leads to mislocalisation of gamma-adaptin.
Topics: Adaptor Protein Complex gamma Subunits; Amino Acid Sequence; Animals; Base Sequence; Brefeldin A; Cell Membrane; Cells, Cultured; Chlorocebus aethiops; Cyclopentanes; Fluorescent Antibody Technique; Glycoproteins; Humans; Membrane Glycoproteins; Membrane Proteins; Molecular Sequence Data; Mutation; Oligodeoxyribonucleotides; Rats; Sequence Deletion; Subcellular Fractions; Transfection | 1994 |
Evidence for cleavage of the PC1/PC3 pro-segment in the endoplasmic reticulum.
Topics: Animals; Aspartic Acid Endopeptidases; Brefeldin A; Cyclopentanes; Endoplasmic Reticulum; Glycosylation; Hexosaminidases; Mice; Neoplasm Proteins; Pituitary Neoplasms; Proprotein Convertase 1; Proprotein Convertases; Protein Processing, Post-Translational; Tumor Cells, Cultured | 1994 |
Brefeldin A inhibits insulin-induced glucose transport stimulation and GLUT4 recruitment in rat adipocytes.
Topics: Adipocytes; Aluminum Compounds; Animals; Brefeldin A; Cell Compartmentation; Cell Membrane; Cyclopentanes; Fluorides; Glucose; Glucose Transporter Type 4; Insulin; Insulin Antagonists; Male; Monosaccharide Transport Proteins; Muscle Proteins; Rats; Rats, Sprague-Dawley | 1994 |
Biosynthetic and structural studies on Thy-1 in a rat neuronal tumor cell line.
Topics: 1-Deoxynojirimycin; Animals; Antigens, Surface; Biological Transport; Brefeldin A; Chromatography, High Pressure Liquid; Cyclopentanes; Fucose; Glycosylation; Indolizines; Mannose; Mannosyl-Glycoprotein Endo-beta-N-Acetylglucosaminidase; Membrane Glycoproteins; Neurons; Rats; Swainsonine; Thy-1 Antigens; Tumor Cells, Cultured; Tunicamycin | 1993 |
A prion protein cycles between the cell surface and an endocytic compartment in cultured neuroblastoma cells.
Topics: Animals; Biological Transport; Brefeldin A; Cell Compartmentation; Cell Membrane; Chickens; Cyclopentanes; Endocytosis; Hydrolysis; Iodine; Lysosomes; Mice; Microscopy, Fluorescence; Neuroblastoma; Prions; PrPSc Proteins; Tumor Cells, Cultured | 1993 |
Microtubule independent vesiculation of Golgi membranes and the reassembly of vesicles into Golgi stacks.
Topics: Animals; Anti-Bacterial Agents; Brefeldin A; Cell Line; Cyclopentanes; Cytoplasm; Golgi Apparatus; Intracellular Membranes; Microscopy, Electron; Microtubules; Paclitaxel; Quinones; Rats; Temperature | 1993 |
Protection from adriamycin cytotoxicity in L1210 cells by brefeldin A.
Topics: Amsacrine; Animals; Biological Transport; Brefeldin A; Cell Survival; Cyclopentanes; DNA Damage; DNA Repair; Doxorubicin; Drug Synergism; Endoplasmic Reticulum; Etoposide; Golgi Apparatus; Kinetics; Leukemia L1210; Mice; Microtubules; Nocodazole; Paclitaxel; Temperature; Tumor Cells, Cultured; Tumor Stem Cell Assay | 1993 |
An activating mutation in ARF1 stabilizes coatomer binding to Golgi membranes.
Topics: ADP-Ribosylation Factor 1; ADP-Ribosylation Factors; Animals; Brefeldin A; Carrier Proteins; CHO Cells; Cloning, Molecular; Coatomer Protein; Cricetinae; Cyclopentanes; Drug Resistance; Golgi Apparatus; GTP-Binding Proteins; Guanosine Triphosphate; Kinetics; Liver; Membrane Proteins; Mutagenesis, Site-Directed; Point Mutation; Protein Binding; Protein Synthesis Inhibitors; Rats; Recombinant Proteins | 1994 |
Molecular characterization and cloning of an esterase which inactivates the macrolide toxin brefeldin A.
Topics: Amino Acid Sequence; Anti-Bacterial Agents; Bacillus subtilis; Base Sequence; Brefeldin A; Carboxylic Ester Hydrolases; Chromatography, Gel; Chromatography, Ion Exchange; Cloning, Molecular; Cyclopentanes; DNA, Bacterial; Electrophoresis, Polyacrylamide Gel; Escherichia coli; Gene Expression; Genes, Bacterial; Immunoblotting; Molecular Sequence Data; Molecular Weight; Oligonucleotide Probes; Plants; Recombinant Proteins; Restriction Mapping; Sequence Homology, Amino Acid; Substrate Specificity | 1994 |
Processing of human acid sphingomyelinase in normal and I-cell fibroblasts.
Topics: Ammonium Chloride; Brefeldin A; Cells, Cultured; Cyclopentanes; Fibroblasts; Glycosylation; Humans; Kinetics; Methionine; Molecular Weight; Mucolipidoses; Protein Processing, Post-Translational; Protein Synthesis Inhibitors; Recombinant Proteins; Reference Values; Skin; Sphingomyelin Phosphodiesterase; Sulfur Radioisotopes | 1994 |
Relationship between fluid transport and in situ inhibition of Na(+)-K+ adenosine triphosphatase in corneal endothelium.
Topics: Animals; Biological Transport, Active; Brefeldin A; Cornea; Corneal Edema; Cyclopentanes; Endothelium, Corneal; Ouabain; Protein Synthesis Inhibitors; Rabbits; Sodium-Potassium-Exchanging ATPase | 1994 |
Immunocytochemical localization of the neuropeptide-synthesizing enzyme PC1 in AtT-20 cells.
Topics: Animals; Aspartic Acid Endopeptidases; Brefeldin A; Cells, Cultured; Cyclopentanes; Endoplasmic Reticulum; Enkephalin, Methionine; Enkephalins; Golgi Apparatus; Immunohistochemistry; Mice; Proprotein Convertase 1; Proprotein Convertases; Protein Precursors; Protein Synthesis Inhibitors | 1993 |
Cell death induced by peroxidized low-density lipoprotein: endopepsis.
Topics: Adenocarcinoma; Brefeldin A; Cell Death; Cyclopentanes; Drug Synergism; Endopeptidases; Fibrosarcoma; Hip; Humans; Hydrolases; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Kinetics; Lipoproteins, LDL; Lysosomes; Male; Mitochondria; Neoplasms, Experimental; Peroxides; Prostatic Neoplasms; Protein Synthesis Inhibitors; Receptors, LDL; Tumor Cells, Cultured | 1994 |
gp74 a membrane glycoprotein of the cis-Golgi network that cycles through the endoplasmic reticulum and intermediate compartment.
Topics: Aluminum Compounds; Animals; Antibodies, Monoclonal; Brefeldin A; Cell Line; Cyclopentanes; Endoplasmic Reticulum; Fluorescent Antibody Technique; Fluorides; Golgi Apparatus; Kidney; Kinetics; Membrane Glycoproteins; Microscopy, Immunoelectron; Molecular Weight; Organelles; Protein Synthesis Inhibitors; Rats; Temperature | 1994 |
The coated pit and macropinocytic pathways serve distinct endosome populations.
Topics: Brefeldin A; Cell Line; Coated Pits, Cell-Membrane; Cyclopentanes; Endocytosis; Epidermal Growth Factor; Humans; Membrane Fusion; Organelles; Pinocytosis; Protein Synthesis Inhibitors; Transferrin; Tumor Cells, Cultured | 1994 |
Differential effect of brefeldin A on phosphorylation of the caseins in lactating mouse mammary epithelial cells.
Topics: Animals; Brefeldin A; Caseins; Cyclopentanes; Epithelium; Female; Golgi Apparatus; In Vitro Techniques; Lactation; Mammary Glands, Animal; Mice; Phosphorylation; Protein Synthesis Inhibitors | 1993 |
Regulation of pathways within cultured epithelial cells for the transcytosis of a basal membrane-bound peroxidase-polylysine conjugate.
Topics: Animals; Biological Transport; Brefeldin A; Cell Polarity; Cyclopentanes; Dose-Response Relationship, Drug; Endocytosis; Epithelium; Horseradish Peroxidase; Leupeptins; Models, Biological; Polylysine; Protease Inhibitors; Tetradecanoylphorbol Acetate; Time Factors | 1993 |
Insulin-sensitive association of GLUT-4 with endocytic clathrin-coated vesicles revealed with the use of brefeldin A.
Topics: 3T3 Cells; Adipocytes; Animals; Brefeldin A; Cell Fractionation; Cell Membrane; Clathrin; Coated Pits, Cell-Membrane; Cyclopentanes; Electrophoresis, Polyacrylamide Gel; Endocytosis; Fluorescent Antibody Technique; Glucose Transporter Type 4; Insulin; Intracellular Membranes; Membrane Proteins; Mice; Molecular Weight; Monosaccharide Transport Proteins; Muscle Proteins; Protein Synthesis Inhibitors; Subcellular Fractions | 1994 |
Regulated intracellular degradation of apolipoprotein B in semipermeable HepG2 cells.
Topics: Adenosine Triphosphate; Apolipoproteins B; Biological Transport; Brefeldin A; Calcimycin; Cell Membrane Permeability; Cycloheximide; Cyclopentanes; Cytoplasm; Digitonin; Endoplasmic Reticulum; Guanosine Triphosphate; Humans; Hydrogen-Ion Concentration; In Vitro Techniques; Monensin; Nocodazole; Protease Inhibitors; Temperature; Tumor Cells, Cultured; Tunicamycin | 1994 |
Effect of brefeldin A on lymphatic triacylglycerol transport in the rat.
Topics: Animals; Biological Transport; Brefeldin A; Chylomicrons; Cyclopentanes; Intestinal Absorption; Intestinal Mucosa; Lipid Metabolism; Lipids; Lipoproteins, VLDL; Lymphatic System; Male; Rats; Rats, Sprague-Dawley; Triglycerides | 1994 |
Differential effects of brefeldin A on hormonally regulated Na+ transport in a model renal epithelial cell line.
Topics: Aldosterone; Animals; Biological Transport; Brefeldin A; Cell Line; Colforsin; Cyclopentanes; Epithelium; Hormones; Insulin; Kidney; Models, Biological; Sodium; Xenopus laevis | 1994 |
Transport of newly synthesized glucosylceramide to the plasma membrane by a non-Golgi pathway.
Topics: Animals; Biological Transport; Brefeldin A; Cell Fractionation; Cell Membrane; Ceramides; CHO Cells; Chromatography, Affinity; Cricetinae; Cyclopentanes; Cytoplasm; G(M3) Ganglioside; Glucose; Glucosylceramides; Kinetics; Palmitic Acid; Palmitic Acids; Sphingomyelins | 1994 |
Functions of the Golgi complex in cell division: formation of cell-matrix contacts and cell-cell communication channels in the terminal phase of cytokinesis.
Topics: Animals; Brefeldin A; Cell Adhesion; Cell Communication; Cell Division; Cells, Cultured; Cyclopentanes; Extracellular Matrix; Fibronectins; Golgi Apparatus; Immunohistochemistry; Mannosidases; Rats; Receptors, Fibronectin; Vinculin | 1994 |
Identification of a brefeldin A-insensitive guanine nucleotide-exchange protein for ADP-ribosylation factor in bovine brain.
Topics: ADP-Ribosylation Factors; Animals; Brain; Brefeldin A; Cattle; Cerebral Cortex; Cyclopentanes; Golgi Apparatus; GTP-Binding Proteins; Guanine Nucleotide Exchange Factors; Guanosine Triphosphate; Phosphatidylserines; Proteins | 1994 |
Arginine vasopressin and forskolin regulate apical cell surface expression of epithelial Na+ channels in A6 cells.
Topics: Amiloride; Animals; Arginine Vasopressin; Brefeldin A; Cell Line; Cell Membrane; Colforsin; Cyclopentanes; Kidney; Sodium Channels; Xenopus laevis | 1994 |
A Rab1 mutant affecting guanine nucleotide exchange promotes disassembly of the Golgi apparatus.
Topics: Animals; Brefeldin A; Cells, Cultured; Coatomer Protein; Cyclopentanes; Golgi Apparatus; GTP Phosphohydrolases; GTP-Binding Proteins; In Vitro Techniques; Mannosidases; Microinjections; Microscopy, Electron; Microtubule-Associated Proteins; Mutation; rab1 GTP-Binding Proteins; Rats; Recombinant Proteins | 1994 |
Effect of brefeldin A on ADH-induced transport responses of toad bladder.
Topics: Animals; Biological Transport; Brefeldin A; Bufo marinus; Colforsin; Cycloheximide; Cyclopentanes; Electrophysiology; In Vitro Techniques; Permeability; Sodium; Urinary Bladder; Vasopressins; Water | 1994 |
Morphologic and biochemical analysis of the intracellular trafficking of the Alzheimer beta/A4 amyloid precursor protein.
Topics: Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Axons; Brain; Brefeldin A; Cell Line; Cells, Cultured; Cyclopentanes; Dendrites; Golgi Apparatus; Intracellular Membranes; Neurons; Rats; Rats, Sprague-Dawley | 1994 |
The proregion of cathepsin L is required for proper folding, stability, and ER exit.
Topics: 3T3 Cells; Ammonium Chloride; Animals; Base Sequence; Brefeldin A; Cathepsin L; Cathepsins; Cell Line; Cyclopentanes; Cysteine Endopeptidases; DNA, Complementary; Endopeptidases; Endoplasmic Reticulum; Enzyme Stability; Fluorescent Antibody Technique; Mannose; Mice; Molecular Sequence Data; Phosphorylation; Protein Folding; Protein Precursors; Structure-Activity Relationship | 1994 |
Effect of lovastatin on the cytotoxicity of ricin, modeccin, Pseudomonas toxin, and diphtheria toxin in brefeldin A-sensitive and -resistant cell lines.
Topics: Actin Cytoskeleton; ADP Ribose Transferases; Animals; Bacterial Toxins; Brefeldin A; Cell Line; Cyclopentanes; Diphtheria Toxin; Dogs; Exotoxins; In Vitro Techniques; Lectins; Lovastatin; Plant Lectins; Pseudomonas aeruginosa Exotoxin A; Ribosome Inactivating Proteins, Type 2; Ricin; Vero Cells; Virulence Factors | 1994 |
Retinoic acid disrupts the Golgi apparatus and increases the cytosolic routing of specific protein toxins.
Topics: 4-Chloro-7-nitrobenzofurazan; Animals; Antibodies, Monoclonal; Biological Transport; Brefeldin A; Cell Line; Ceramides; Cholecalciferol; Cyclopentanes; Cytosol; Fluorescent Dyes; Gene Expression Regulation; Golgi Apparatus; Humans; Immunotoxins; Mannosidases; Rats; Receptors, Retinoic Acid; Ricin; Tretinoin; Triiodothyronine; Tumor Cells, Cultured | 1994 |
Characterization of 3'-azido-3'-deoxythymidine inhibition of ricin and Pseudomonas exotoxin A toxicity in CHO and Vero cells.
Topics: ADP Ribose Transferases; Animals; Bacterial Toxins; Biological Transport; Brefeldin A; Cell Survival; Cerulenin; CHO Cells; Colchicine; Cricetinae; Cyclopentanes; Dose-Response Relationship, Drug; Exotoxins; Kinetics; Leucine; NAD; Nocodazole; Protein Biosynthesis; Protein Synthesis Inhibitors; Pseudomonas aeruginosa; Pseudomonas aeruginosa Exotoxin A; Rabbits; Reticulocytes; Ricin; Vero Cells; Virulence Factors; Zidovudine | 1994 |
An H2-T MHC class Ib molecule presents Listeria monocytogenes-derived antigen to immune CD8+ cytotoxic T cells.
Topics: Amino Acid Sequence; Animals; Antigen Presentation; Antigens, Bacterial; Bacterial Toxins; Brefeldin A; CD8 Antigens; Cell Line; Concanavalin A; Cyclopentanes; Cytotoxicity, Immunologic; Female; Heat-Shock Proteins; Hemolysin Proteins; Histocompatibility Antigens Class I; Listeria monocytogenes; Mice; Mice, Inbred Strains; Molecular Sequence Data; T-Lymphocytes, Cytotoxic | 1994 |
A peripheral protein associated with the cis-Golgi network redistributes in the intermediate compartment upon brefeldin A treatment.
Topics: Autoantigens; Brefeldin A; Calcimycin; Cell Compartmentation; Cell Line; Cyclopentanes; Electrophoresis, Gel, Two-Dimensional; Fluorescent Antibody Technique; Golgi Apparatus; HeLa Cells; Humans; Immunologic Techniques; In Vitro Techniques; Intracellular Membranes; Isoelectric Point; Membrane Proteins; Molecular Weight; Nocodazole; Sjogren's Syndrome | 1994 |
Temporal down-regulation of Fc gamma RIII expression and Fc gamma receptor-mediated phagocytosis in human monocyte-derived macrophages induced by TNF-alpha and IL-1 beta.
Topics: Brefeldin A; Cells, Cultured; Cyclopentanes; Down-Regulation; Flow Cytometry; Humans; Interleukin-1; Kinetics; Macrophages; Monocytes; Phagocytosis; Protein Synthesis Inhibitors; Receptors, IgG; Time Factors; Tumor Necrosis Factor-alpha | 1994 |
Disruption of the Golgi apparatus by brefeldin A blocks cell polarization and inhibits directed cell migration.
Topics: 3T3 Cells; Animals; Brefeldin A; Cell Movement; Cell Polarity; Cell Size; Cyclopentanes; Cytoskeleton; Golgi Apparatus; In Vitro Techniques; Mice | 1994 |
Regulation of MHC class I membrane expression by beta 2-microglobulin.
Topics: Amino Acid Sequence; Animals; Anti-Bacterial Agents; Antigens, Surface; beta 2-Microglobulin; Brefeldin A; Chloroquine; Cyclopentanes; Flow Cytometry; Histocompatibility Antigens Class I; Humans; Mice; Molecular Sequence Data; Peptides; T-Lymphocytes, Cytotoxic; Tumor Cells, Cultured; Up-Regulation | 1993 |
Identification and localization of ERD2 in the malaria parasite Plasmodium falciparum: separation from sites of sphingomyelin synthesis and implications for organization of the Golgi.
Topics: Amino Acid Sequence; Animals; Antibodies, Protozoan; Base Sequence; Brefeldin A; Cloning, Molecular; Cyclopentanes; Fluorescent Antibody Technique; Golgi Apparatus; Membrane Proteins; Molecular Sequence Data; Oligodeoxyribonucleotides; Plasmodium falciparum; Protozoan Proteins; Receptors, Peptide; Saccharomyces cerevisiae Proteins; Sequence Homology, Amino Acid; Sphingomyelins | 1993 |
Defective secretion of albumin encoded by exon-skipped mRNA found in aged analbuminemic rat liver.
Topics: Aging; Animals; Base Sequence; Brefeldin A; Carcinoma, Hepatocellular; Cell Compartmentation; Cell Line; Chlorocebus aethiops; Cyclopentanes; DNA, Complementary; Exons; Humans; Liver; Liver Neoplasms; Molecular Sequence Data; Rats; Rats, Sprague-Dawley; Recombinant Fusion Proteins; RNA, Messenger; Serum Albumin; Transfection; Tumor Cells, Cultured | 1993 |
Brefeldin A effects on tobacco pollen tubes.
Topics: Biological Transport; Brefeldin A; Cyclopentanes; Cytoskeleton; Endoplasmic Reticulum; Golgi Apparatus; Microscopy, Electron; Nicotiana; Plants, Toxic; Pollen; Polysaccharides | 1993 |
Different assembly species of IgM are directed to distinct degradation sites along the secretory pathway.
Topics: Animals; B-Lymphocytes; Brefeldin A; Cell Line; Cyclopentanes; Endoplasmic Reticulum; Golgi Apparatus; Immunoglobulin Heavy Chains; Immunoglobulin Light Chains; Immunoglobulin Light Chains, Surrogate; Immunoglobulin M; Immunoglobulin mu-Chains; Lysosomes; Membrane Glycoproteins; Mice | 1993 |
HLA-A2 presents shared tumor-associated antigens derived from endogenous proteins in ovarian cancer.
Topics: Antigen Presentation; Antigens, Neoplasm; Brefeldin A; Chloroquine; Cyclopentanes; Cytotoxicity, Immunologic; Female; HLA-A2 Antigen; Humans; Lymphocytes, Tumor-Infiltrating; Ovarian Neoplasms; T-Lymphocytes, Cytotoxic; Tumor Cells, Cultured | 1993 |
70 kDa heat shock cognate protein is a transformation-associated antigen and a possible target for the host's anti-tumor immunity.
Topics: Animals; Antibodies, Monoclonal; Antigens, Neoplasm; Biological Transport; Brefeldin A; Cyclopentanes; Cytotoxicity, Immunologic; Heat-Shock Proteins; Molecular Weight; Neoplasms; Rats; Rats, Inbred Strains; T-Lymphocytes | 1993 |
Dynamic equilibrium between vesicular stomatitis virus glycoprotein monomers and trimers in the Golgi and at the cell surface.
Topics: Animals; Antibodies, Viral; Antibody Specificity; Biological Transport; Brefeldin A; Cell Compartmentation; Cell Membrane; Cells, Cultured; Cricetinae; Cyclopentanes; Golgi Apparatus; Hexosaminidases; Membrane Glycoproteins; Mutation; Postural Balance; Protein Conformation; Protein Processing, Post-Translational; Vesicular stomatitis Indiana virus; Viral Envelope Proteins | 1993 |
Salmonella typhimurium induces membrane ruffling by a growth factor-receptor-independent mechanism.
Topics: 3T3 Cells; Actins; Animals; Brefeldin A; Cell Line; Cell Membrane; Cells, Cultured; Cyclopentanes; Dogs; Epidermal Growth Factor; ErbB Receptors; GTP Phosphohydrolases; Humans; Intestines; Kidney; Mice; Salmonella typhimurium; Tumor Cells, Cultured | 1993 |
Normal cellular processing of the beta-amyloid precursor protein results in the secretion of the amyloid beta peptide and related molecules.
Topics: Amino Acid Sequence; Ammonium Chloride; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Brefeldin A; Cell Line; Colchicine; Cyclopentanes; Golgi Apparatus; Humans; Kidney; Leupeptins; Lysosomes; Molecular Sequence Data; Monensin; Nocodazole; Protein Processing, Post-Translational; Transfection | 1993 |
Post-translational processing of progastrin: inhibition of cleavage, phosphorylation and sulphation by brefeldin A.
Topics: Animals; Biological Transport; Brefeldin A; Chromatography, High Pressure Liquid; Cyclopentanes; Gastric Mucosa; Gastrins; Immunosorbent Techniques; Male; Peptide Fragments; Phosphates; Phosphorylation; Protein Precursors; Protein Processing, Post-Translational; Rats; Rats, Wistar; Sulfates; Trypsin; Tyrosine | 1993 |
Generation of beta A4 from the amyloid protein precursor and fragments thereof.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Brefeldin A; Culture Media, Conditioned; Cyclopentanes; Gene Expression; Humans; Kinetics; Methylamines; Monensin; Neuroblastoma; Peptide Fragments; Plasmids; Transfection; Tumor Cells, Cultured | 1993 |
Targeting and mistargeting of plasma membrane adaptors in vitro.
Topics: Adaptor Protein Complex alpha Subunits; Adaptor Protein Complex beta Subunits; Adaptor Protein Complex gamma Subunits; Adaptor Proteins, Vesicular Transport; Animals; Biological Transport; Brefeldin A; Calcium; Cell Line; Cell Membrane; Cell Nucleus; Coated Pits, Cell-Membrane; Cyclopentanes; Cytoplasm; Fluorescent Antibody Technique; Guanosine 5'-O-(3-Thiotriphosphate); Intracellular Membranes; Proteins; Rats | 1993 |
Neural differentiation in cleavage-arrested ascidian blastomeres induced by a proteolytic enzyme.
Topics: Animals; Anti-Bacterial Agents; Blastomeres; Brefeldin A; Cell Differentiation; Cell Membrane; Cleavage Stage, Ovum; Cyclopentanes; Endopeptidases; Larva; Macrolides; Monensin; Neurons; Phenotype; Subtilisins; Urochordata | 1993 |
"BFA bodies": a subcompartment of the endoplasmic reticulum.
Topics: Animals; Brefeldin A; Coatomer Protein; Cyclopentanes; Endoplasmic Reticulum; Golgi Apparatus; Immunohistochemistry; Intracellular Membranes; Islets of Langerhans; Membrane Proteins; Microscopy, Electron; Microtubule-Associated Proteins; Rats | 1993 |
Sphingomyelin transport to the cell surface occurs independently of protein secretion in rat hepatocytes.
Topics: Albumins; Animals; Biological Transport; Brefeldin A; Cell Membrane; Cells, Cultured; Cyclopentanes; Energy Metabolism; Liver; Male; Monensin; Proteins; Rats; Rats, Sprague-Dawley; Sphingomyelin Phosphodiesterase; Sphingomyelins; Temperature | 1993 |
Entry of cholera toxin into polarized human intestinal epithelial cells. Identification of an early brefeldin A sensitive event required for A1-peptide generation.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Analysis of Variance; Biological Transport; Brefeldin A; Cell Line; Cell Membrane; Chlorides; Cholera Toxin; Cyclic AMP-Dependent Protein Kinases; Cyclopentanes; Dose-Response Relationship, Drug; Humans; Intestinal Mucosa; Kinetics; Models, Biological; NAD; Protein Binding; Protein Synthesis Inhibitors; Temperature; Time Factors; Vasoactive Intestinal Peptide | 1993 |
Brefeldin A defines distinct pathways for atrial natriuretic factor secretion in neonatal rat atrial and ventricular myocytes.
Topics: Animals; Animals, Newborn; Atrial Natriuretic Factor; Brefeldin A; Cells, Cultured; Cyclopentanes; Heart Atria; Heart Ventricles; Mycotoxins; Myocardium; Protein Precursors; Protein Processing, Post-Translational; Rats; Time Factors | 1994 |
Brefeldin A inhibits muscle-specific gene expression during differentiation in C2C12 myoblasts.
Topics: Animals; Biological Transport; Brefeldin A; Cell Compartmentation; Cell Differentiation; Cell Fusion; Creatine Kinase; Cyclopentanes; Gene Expression; Golgi Apparatus; Mice; Muscle Proteins; Muscles; MyoD Protein; Myogenin; RNA, Messenger | 1993 |
Timing of palmitoylation of influenza virus hemagglutinin.
Topics: Animals; Brefeldin A; Cells, Cultured; Chick Embryo; Cycloheximide; Cyclopentanes; Hemagglutinin Glycoproteins, Influenza Virus; Hemagglutinins, Viral; Hydrolysis; Palmitic Acid; Palmitic Acids; Time Factors | 1993 |
Analysis of lactase processing in rabbit.
Topics: Animals; Brefeldin A; Cell Fractionation; Colchicine; Cyclopentanes; Enzyme Precursors; Glycosylation; Golgi Apparatus; Hydrolysis; Lactase-Phlorizin Hydrolase; Microvilli; Monensin; Organ Culture Techniques; Protein Processing, Post-Translational; Rabbits | 1993 |
Involvement of the lysosome in the catabolism of intracellular lysophosphatidylcholine and evidence for distinct pools of lysophosphatidylcholine.
Topics: Albumins; Animals; Brefeldin A; Chloroquine; Choline; Cyclopentanes; Cytidine Diphosphate Choline; Liver; Lysophosphatidylcholines; Lysosomes; Methionine; Methylation; Phosphatidylcholines; Rats; Tritium | 1993 |
Inhibition of intracellular transport of newly synthesized prolactin by bafilomycin A1 in a pituitary tumor cell line, GH3 cells.
Topics: Animals; Anti-Bacterial Agents; Biological Transport; Brefeldin A; Cyclopentanes; Cytoplasmic Granules; Golgi Apparatus; Macrolides; Microscopy, Immunoelectron; Pituitary Neoplasms; Prolactin; Rats; Tumor Cells, Cultured | 1993 |
GLUT2 surface expression and intracellular transport via the constitutive pathway in pancreatic beta cells and insulinoma: evidence for a block in trans-Golgi network exit by brefeldin A.
Topics: Animals; Blotting, Western; Brefeldin A; Cell Line; Cell Membrane; Cells, Cultured; Cyclopentanes; Glucose Transporter Type 2; Golgi Apparatus; Insulinoma; Islets of Langerhans; Kinetics; Monosaccharide Transport Proteins; Pancreatic Neoplasms; Protein Processing, Post-Translational; Protein Structure, Secondary; Protein Synthesis Inhibitors; Rats; Rats, Sprague-Dawley; Trypsin; Tumor Cells, Cultured | 1993 |
Brefeldin A blocks protein glycosylation and RNA replication of vesicular stomatitis virus.
Topics: Animals; Antiviral Agents; Blotting, Northern; Brefeldin A; Cell Line; Cricetinae; Cyclopentanes; Electrophoresis, Polyacrylamide Gel; Glycosylation; HeLa Cells; Humans; Kidney; RNA, Viral; Vesicular stomatitis Indiana virus; Viral Proteins | 1993 |
Inhibition of constitutive protein secretion from lactating mouse mammary epithelial cells by FIL (feedback inhibitor of lactation), a secreted milk protein.
Topics: Animals; Brefeldin A; Caseins; Cyclopentanes; Endoplasmic Reticulum; Exocytosis; Feedback; Female; Golgi Apparatus; In Vitro Techniques; Lactation; Mammary Glands, Animal; Mice; Microscopy, Electron; Milk Proteins; Pregnancy | 1993 |
Processing and intracellular transport of cathepsin G and neutrophil elastase in the leukemic myeloid cell line U-937-modulation by brefeldin A, ammonium chloride, and monensin.
Topics: Ammonium Chloride; Antifungal Agents; Biological Transport; Brefeldin A; Cathepsin G; Cathepsins; Cyclopentanes; Humans; Hydrogen-Ion Concentration; Leukemia, Myeloid; Leukocyte Elastase; Monensin; Pancreatic Elastase; Peroxidase; Serine Endopeptidases; Tumor Cells, Cultured | 1994 |
Brefeldin A protects ricin-induced cytotoxicity in human cancer KB cell line, but not in its resistant counterpart with altered Golgi structures.
Topics: Adaptor Protein Complex gamma Subunits; Amino Acid Sequence; Brefeldin A; Coatomer Protein; Cyclopentanes; Diphtheria Toxin; Drug Resistance; Fluorescent Antibody Technique; Golgi Apparatus; Humans; KB Cells; Kinetics; Membrane Proteins; Microscopy, Electron; Microtubule-Associated Proteins; Molecular Sequence Data; Monensin; Protein Biosynthesis; Protein Synthesis Inhibitors; Proteins; Ricin | 1993 |
Expression of a dominant allele of human ARF1 inhibits membrane traffic in vivo.
Topics: ADP-Ribosylation Factor 1; ADP-Ribosylation Factors; Alleles; Animals; Brefeldin A; Cell Line; Coatomer Protein; Cyclopentanes; Endocytosis; Endoplasmic Reticulum; Gene Expression; Genes, Dominant; Golgi Apparatus; GTP-Binding Proteins; Humans; Interferon-alpha; Interferon-beta; Membrane Proteins; Microscopy, Electron; Microtubule-Associated Proteins; Mutation; Proteins; Rats; Transfection | 1994 |
Structural disruption of the trans-Golgi network does not interfere with the acute stimulation of glucose and amino acid uptake by insulin-like growth factor I in muscle cells.
Topics: Amino Acids; Animals; Biological Transport; Brefeldin A; Cell Line; Cyclopentanes; Glucose; Glucose Transporter Type 1; Glucose Transporter Type 3; Glucose Transporter Type 4; Glycoproteins; Golgi Apparatus; Insulin-Like Growth Factor I; Membrane Glycoproteins; Membrane Proteins; Monosaccharide Transport Proteins; Muscle Proteins; Muscles; Nerve Tissue Proteins; Rats | 1994 |
Continuous but not intermittent administration of growth hormone to hypophysectomized rats increases apolipoprotein-E secretion from cultured hepatocytes.
Topics: Animals; Apolipoproteins E; Blotting, Northern; Brefeldin A; Cattle; Cells, Cultured; Cyclopentanes; Drug Administration Schedule; Female; Growth Hormone; Hydrocortisone; Hypophysectomy; Kinetics; Liver; Protein Synthesis Inhibitors; Rats; Rats, Sprague-Dawley; RNA, Messenger; Sex Factors; Thyroxine; Time Factors; Weight Gain | 1994 |
Heat shock glycoprotein GP50: product of the retinoic acid-inducible J6 gene.
Topics: Animals; Arsenites; Brefeldin A; Cell Division; Cell Hypoxia; CHO Cells; Cricetinae; Cyclopentanes; Ethers, Cyclic; Gene Expression Regulation; Heat-Shock Proteins; Hot Temperature; Hydrogen Peroxide; Kinetics; Mice; Molecular Weight; Nerve Tissue Proteins; Okadaic Acid; Protein Synthesis Inhibitors; Protein Tyrosine Phosphatases; Quercetin; RNA, Messenger; Sodium Compounds; Teratoma; Transcription, Genetic; Tretinoin; Ultraviolet Rays; X-Rays | 1994 |
A monoclonal antibody that recognizes HLA-B27 in the context of peptides.
Topics: Amino Acid Sequence; Antigen-Presenting Cells; Antigens, Viral; Brefeldin A; Cyclopentanes; Heat-Shock Proteins; Histones; HLA-B27 Antigen; Humans; Interferon-gamma; Molecular Sequence Data; Peptides; Recombinant Proteins; Temperature; Tumor Necrosis Factor-alpha | 1994 |
Up-regulation of the MHC class II molecules on B cells by peptide ligands.
Topics: Amino Acid Sequence; Animals; Antigen-Presenting Cells; B-Lymphocytes; Brefeldin A; Cell Line; Complement C1q; Cycloheximide; Cyclopentanes; Histocompatibility Antigens Class II; Ligands; Mice; Molecular Sequence Data; Peptides | 1994 |
Stimulation of endogenous ADP-ribosylation by brefeldin A.
Topics: Adenosine Diphosphate Ribose; ADP Ribose Transferases; ADP-Ribosylation Factors; Animals; Biological Transport, Active; Brefeldin A; Cell Line; Cyclopentanes; Glyceraldehyde-3-Phosphate Dehydrogenases; GTP-Binding Proteins; Mycotoxins; NAD; Poly(ADP-ribose) Polymerases; Proteins; Rats; Substrate Specificity | 1994 |
Localization of O-glycan initiation, sphingomyelin synthesis, and glucosylceramide synthesis in Vero cells with respect to the endoplasmic reticulum-Golgi intermediate compartment.
Topics: Amino Acid Sequence; Animals; Brefeldin A; Cell Compartmentation; Cell Line; Chlorocebus aethiops; Cyclopentanes; Endoplasmic Reticulum; Galactosyltransferases; Glucosylceramides; Golgi Apparatus; Molecular Sequence Data; Peptides; Polysaccharides; Sphingomyelins; Transferases (Other Substituted Phosphate Groups) | 1994 |
The small GTP-binding protein rab6p is redistributed in the cytosol by brefeldin A.
Topics: 3T3 Cells; Aluminum Compounds; Animals; Biological Transport; Brefeldin A; Cell Fractionation; Cell Line; Cyclopentanes; Cytosol; Fluorescent Antibody Technique; Fluorides; Golgi Apparatus; GTP-Binding Proteins; Kinetics; Mice | 1993 |
Effect of brefeldin A on the structure of the Golgi apparatus and on the synthesis and secretion of proteins and polysaccharides in sycamore maple (Acer pseudoplatanus) suspension-cultured cells.
Topics: Brefeldin A; Cell Wall; Cells, Cultured; Cyclopentanes; Fucose; Glycoproteins; Golgi Apparatus; Mannose; Plant Proteins; Polysaccharides; Trees; Xylose | 1993 |
Pre-Golgi degradation of yeast prepro-alpha-factor expressed in a mammalian cell. Influence of cell type-specific oligosaccharide processing on intracellular fate.
Topics: 1-Deoxynojirimycin; Animals; Brefeldin A; Carbohydrate Sequence; Cyclopentanes; Endoplasmic Reticulum; Fungal Proteins; Glycosylation; Golgi Apparatus; Kinetics; Molecular Sequence Data; Oligosaccharides; Protein Precursors; Protein Processing, Post-Translational; Protein Sorting Signals; Recombinant Proteins; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Transfection; Tumor Cells, Cultured; Tunicamycin | 1993 |
Characterization of a novel 63 kDa membrane protein. Implications for the organization of the ER-to-Golgi pathway.
Topics: Animals; Antibodies, Monoclonal; Antigens; Biological Transport; Brefeldin A; Cell Compartmentation; Cyclopentanes; Endoplasmic Reticulum; Exocytosis; Golgi Apparatus; Intracellular Membranes; Lasers; Membrane Proteins; Microscopy, Fluorescence; Microscopy, Immunoelectron; Molecular Weight; Organelles; Temperature; Vero Cells | 1993 |
A reversibly palmitoylated resident protein (p63) of an ER-Golgi intermediate compartment is related to a circulatory shock resuscitation protein.
Topics: Amino Acid Sequence; Animals; Base Sequence; Brefeldin A; Cell Compartmentation; Cell Line; Cloning, Molecular; Cyclopentanes; DNA; Endoplasmic Reticulum; Golgi Apparatus; Humans; Membrane Proteins; Molecular Sequence Data; Palmitic Acids; RNA, Messenger; Sequence Analysis, DNA; Shock | 1993 |
Epithelial sphingolipid sorting is insensitive to reorganization of the Golgi by nocodazole, but is abolished by monensin in MDCK cells and by brefeldin A in Caco-2 cells.
Topics: Animals; Biological Transport; Brefeldin A; Cell Line; Cell Membrane; Cyclopentanes; Epithelium; Golgi Apparatus; Monensin; Nocodazole; Sphingolipids | 1993 |
Analysis of brefeldin A in plasma by gas chromatography with electron capture detection.
Topics: Animals; Antineoplastic Agents; Brefeldin A; Chromatography, Gas; Cyclopentanes; Electrons; Gas Chromatography-Mass Spectrometry; Male; Mice; Reproducibility of Results | 1993 |
Both the alpha and beta chains of high-affinity interleukin 2 receptors are located in intracellular vesicles when their ligand is endocytosed.
Topics: Brefeldin A; Clone Cells; Cycloheximide; Cyclopentanes; Endocytosis; Humans; Interleukin-2; Molecular Weight; Receptors, Interleukin-2; T-Lymphocytes; Tumor Cells, Cultured | 1993 |
A 102 kDa subunit of a Golgi-associated particle has homology to beta subunits of trimeric G proteins.
Topics: Amino Acid Sequence; Animals; Antibodies, Monoclonal; Blotting, Western; Brefeldin A; Cloning, Molecular; Coatomer Protein; Cross Reactions; Cyclopentanes; DNA; Golgi Apparatus; GTP-Binding Proteins; HeLa Cells; Humans; Intracellular Membranes; Membrane Proteins; Mice; Molecular Sequence Data; Sequence Homology, Amino Acid; Transducin | 1993 |
Prompt protein glycosylation during acute heat stress.
Topics: Animals; Anti-Bacterial Agents; Brefeldin A; CHO Cells; Cricetinae; Cyclopentanes; Electrophoresis, Polyacrylamide Gel; Glucose; Glycoproteins; Glycosylation; Heat-Shock Proteins; Hot Temperature; Mannose; Oligosaccharides; Stress, Physiological; Time Factors; Tritium; Tunicamycin | 1993 |
Ontogeny of corneal epithelial tight junctions: stratal locale of biosynthetic activities.
Topics: Amanitins; Animals; Biological Transport; Brefeldin A; Cell Membrane Permeability; Cornea; Cycloheximide; Cyclopentanes; Electrophysiology; Epithelium; Glycosylation; Intercellular Junctions; Mannitol; Membrane Potentials; Rabbits; Transcription, Genetic | 1993 |
Differential effect of brefeldin A on the biosynthesis of heparan sulfate and chondroitin/dermatan sulfate proteoglycans in rat ovarian granulosa cells in culture.
Topics: Animals; Brefeldin A; Cells, Cultured; Chondroitin Sulfate Proteoglycans; Chromatography, Gel; Chromatography, Ion Exchange; Cyclopentanes; Female; Granulosa Cells; Heparitin Sulfate; Kinetics; Rats; Rats, Sprague-Dawley | 1993 |
Secretion of chondroitin sulfate from embryonic epidermal cells in Xenopus laevis.
Topics: Animals; Antifungal Agents; Brefeldin A; Chondroitin; Chondroitin Sulfates; Cyclopentanes; Cytoplasmic Granules; Epidermal Cells; Epidermis; Fluorescent Antibody Technique; Glycosaminoglycans; Microscopy, Immunoelectron; Time Factors; Xenopus laevis | 1993 |
Retinoic-acid-induced augmentation of molecular species carrying sialosyl Lewis(a) antigen in colorectal-carcinoma cell cultures.
Topics: Antigens, Tumor-Associated, Carbohydrate; Blotting, Western; Brefeldin A; CA-19-9 Antigen; Cell Division; Cell Size; Chromatography, Thin Layer; Colorectal Neoplasms; Cyclopentanes; Drug Synergism; Enzyme-Linked Immunosorbent Assay; Gangliosides; Humans; Protein Binding; Tretinoin; Tumor Cells, Cultured | 1993 |
De novo synthesis of type 1 lacto-series glycolipids in human colonic adenocarcinoma cells: efficient synthesis of the Le(a) antigen and absence of brefeldin A-induced inhibition of its synthesis in Colo 205 cells.
Topics: Adenocarcinoma; Antigens, Tumor-Associated, Carbohydrate; Brefeldin A; CA-19-9 Antigen; Carbohydrate Sequence; Colonic Neoplasms; Cyclopentanes; Gangliosides; Glycolipids; Humans; In Vitro Techniques; Molecular Sequence Data; Tumor Cells, Cultured | 1993 |
Ricin intoxicates End4 mutants that have an aberrant Golgi complex.
Topics: Animals; Anti-Bacterial Agents; Brefeldin A; Cell Survival; CHO Cells; Clone Cells; Cricetinae; Cyclopentanes; Dose-Response Relationship, Drug; Drug Synergism; Golgi Apparatus; Kinetics; Mutagenesis; Protein Synthesis Inhibitors; Ricin; Temperature | 1993 |
Brefeldin-A inhibits the delivery of the polymeric immunoglobulin receptor to the basolateral surface of MDCK cells.
Topics: Animals; Brefeldin A; Cell Line; Cell Membrane; Cyclopentanes; Dogs; Endoplasmic Reticulum; Golgi Apparatus; Immunoglobulin A; Immunoglobulin M; Kidney; Kinetics; Microscopy, Electron; Receptors, Fc; Receptors, Immunologic | 1993 |
Synaptic vesicle proteins and early endosomes in cultured hippocampal neurons: differential effects of Brefeldin A in axon and dendrites.
Topics: Amino Acid Sequence; Animals; Axons; Brefeldin A; Calcium-Binding Proteins; Cells, Cultured; Cyclopentanes; Dendrites; Endocytosis; GTP-Binding Proteins; Hippocampus; Membrane Glycoproteins; Membrane Proteins; Molecular Sequence Data; Nerve Tissue Proteins; Neurons; Organelles; R-SNARE Proteins; rab3 GTP-Binding Proteins; Rats; Receptors, Transferrin; Synaptic Vesicles; Synaptophysin; Synaptotagmins | 1993 |
Truncated ceramide analogs as probes for sphingolipid biosynthesis and transport.
Topics: Animals; Biological Transport; Brefeldin A; Cell Compartmentation; Cell Membrane; Ceramides; Cyclopentanes; G(M3) Ganglioside; Glucosylceramides; Golgi Apparatus; Lactosylceramides; Molecular Probes; Sphingolipids; Sphingomyelins | 1993 |
Role of endoplasmic reticular calcium in oligosaccharide processing of alpha 1-antitrypsin.
Topics: 1-Deoxynojirimycin; alpha 1-Antitrypsin; alpha-Mannosidase; Brefeldin A; Calcium; Calcium-Transporting ATPases; Carbohydrate Conformation; Carcinoma, Hepatocellular; Cyclopentanes; Endoplasmic Reticulum; Glycoside Hydrolase Inhibitors; Hexosaminidases; Humans; Indolizines; Ionomycin; Liver Neoplasms; Mannose; Mannosidases; Mannosyl-Glycoprotein Endo-beta-N-Acetylglucosaminidase; Oligosaccharides; Terpenes; Thapsigargin; Tumor Cells, Cultured | 1993 |
Brefeldin A inhibits phosphate transport in opossum kidney cells.
Topics: Animals; Biological Transport; Brefeldin A; Cell Line; Cyclic AMP; Cycloheximide; Cyclopentanes; Golgi Apparatus; Hormones; Kidney; Leucine; Mycotoxins; Opossums; Phosphates | 1993 |
Progeny vaccinia and human cytomegalovirus particles utilize early endosomal cisternae for their envelopes.
Topics: Brefeldin A; Cyclopentanes; Cytomegalovirus; Fibroblasts; Golgi Apparatus; Horseradish Peroxidase; Humans; Intracellular Membranes; Vaccinia virus; Virion; Virus Shedding | 1993 |
Evidence that the putative COOH-terminal signal transamidase involved in glycosylphosphatidylinositol protein synthesis is present in the endoplasmic reticulum.
Topics: Acyltransferases; Adenosine Triphosphate; Animals; Bacillus thuringiensis; Brefeldin A; Carrier Proteins; Cell Line; Cyclopentanes; Endoplasmic Reticulum; Endoplasmic Reticulum Chaperone BiP; Glycosylphosphatidylinositols; Heat-Shock Proteins; Immunoglobulin Heavy Chains; Microsomes; Models, Biological; Molecular Chaperones; Phosphatidylinositol Diacylglycerol-Lyase; Phosphoric Diester Hydrolases; Protein Biosynthesis; Protein Processing, Post-Translational; Protein Sorting Signals; Proteins; Transfection | 1993 |
Brefeldin A blocks the response of cultured cells to cholera toxin. Implications for intracellular trafficking in toxin action.
Topics: Adenocarcinoma; Adenylyl Cyclases; Animals; Biological Transport; Brefeldin A; Cell Line; Chloroquine; Cholera Toxin; Colonic Neoplasms; Cyclic AMP; Cyclopentanes; Enzyme Activation; Glioma; Golgi Apparatus; Humans; Isoproterenol; Kinetics; Monensin; Mycotoxins; Rats; Time Factors; Tumor Cells, Cultured | 1993 |
Vectorial release of poliovirus from polarized human intestinal epithelial cells.
Topics: Ammonium Chloride; Animals; Brefeldin A; Cell Line; Cell Polarity; Cyclopentanes; Epithelium; In Vitro Techniques; Intestinal Mucosa; Microscopy, Electron; Monensin; Poliovirus; Vero Cells; Vesicular stomatitis Indiana virus; Viral Proteins; Virus Replication | 1993 |
Inhibition of heat-labile cholera and Escherichia coli enterotoxins by brefeldin A.
Topics: Adrenocorticotropic Hormone; Anti-Bacterial Agents; Bacterial Toxins; Brefeldin A; Cells, Cultured; Cholera Toxin; Cyclic AMP; Cyclopentanes; Enterotoxins; Escherichia coli; Escherichia coli Proteins; Golgi Apparatus | 1993 |
TAP2-defective RMA-S cells present Sendai virus antigen to cytotoxic T lymphocytes.
Topics: Animals; Antigen-Presenting Cells; Antigens, Viral; ATP Binding Cassette Transporter, Subfamily B, Member 2; ATP Binding Cassette Transporter, Subfamily B, Member 3; ATP-Binding Cassette Transporters; Brefeldin A; Carrier Proteins; Cell Line; Cyclopentanes; Female; Histocompatibility Antigens Class II; Mice; Mice, Inbred C57BL; Parainfluenza Virus 1, Human; T-Lymphocytes, Cytotoxic; Transfection | 1993 |
Antigen processing mutant T2 cells present viral antigen restricted through H-2Kb.
Topics: Animals; Antigen-Presenting Cells; Antigens, Viral; Brefeldin A; Cell Line; Cyclopentanes; Female; H-2 Antigens; Mice; Mice, Inbred C57BL; Mutation; Orthomyxoviridae; Parainfluenza Virus 1, Human; T-Lymphocytes, Cytotoxic; Vesicular stomatitis Indiana virus | 1993 |
Intracellular transport, organelle biogenesis and establishment of Golgi identity: impact of brefeldin A on the activity of lipid synthesizing enzymes.
Topics: Acyltransferases; Autoradiography; Brefeldin A; Cell Fractionation; Ceramides; Choline-Phosphate Cytidylyltransferase; Cyclopentanes; Diacylglycerol Cholinephosphotransferase; Electrophoresis, Polyacrylamide Gel; Endoplasmic Reticulum; Glycerophosphates; Glycosylation; Golgi Apparatus; Membrane Lipids; Nucleotidyltransferases; Phosphatidylcholines; Serine C-Palmitoyltransferase; Sphingolipids; Sphingosine | 1993 |
The release of soluble p55 TNF receptor from U937 cells studied by a new p55 immunoassay.
Topics: Animals; Antibodies, Monoclonal; Antibody Specificity; Antiviral Agents; Blotting, Northern; Brefeldin A; Cell Line; Cycloheximide; Cyclopentanes; Digoxigenin; Dose-Response Relationship, Immunologic; Flow Cytometry; Humans; Hybridomas; Immunoassay; Mice; Mice, Inbred BALB C; Monensin; Monocytes; Precipitin Tests; Receptors, Cell Surface; Receptors, Tumor Necrosis Factor; RNA, Messenger; Sensitivity and Specificity; Tetradecanoylphorbol Acetate; Tumor Necrosis Factor-alpha | 1993 |
Glucocorticoid-regulated trafficking of mouse mammary tumor virus proteins in permeabilized hepatoma cells. Requirements of intracellular membrane transport for maturation of the cytoplasmic phosphorylated polyprotein.
Topics: Animals; Antiviral Agents; Bacterial Proteins; Brefeldin A; Cell Membrane Permeability; Clone Cells; Cyclopentanes; Cytoplasm; Dexamethasone; Fluorescein-5-isothiocyanate; Fluorescent Antibody Technique; Guanosine 5'-O-(3-Thiotriphosphate); Liver Neoplasms, Experimental; Mammary Tumor Virus, Mouse; Models, Biological; Phosphoproteins; Phosphorylation; Protein Processing, Post-Translational; Rats; Streptolysins; Tumor Cells, Cultured; Viral Proteins | 1993 |
IFN-gamma-induced recognition of the antigen-processing variant CMT.64 by cytolytic T cells can be replaced by sequential addition of beta 2 microglobulin and antigenic peptides.
Topics: Animals; Antigen-Presenting Cells; Antigens, Viral; beta 2-Microglobulin; Brefeldin A; Cyclopentanes; Cytotoxicity, Immunologic; Emetine; Histocompatibility Antigens Class I; Immunity, Cellular; In Vitro Techniques; Interferon-gamma; Lung Neoplasms; Mice; Mice, Inbred C57BL; Peptides; T-Lymphocytes, Cytotoxic; Tumor Cells, Cultured; Vesicular stomatitis Indiana virus | 1993 |
Comparative biosynthesis, covalent post-translational modifications and efficiency of prosegment cleavage of the prohormone convertases PC1 and PC2: glycosylation, sulphation and identification of the intracellular site of prosegment cleavage of PC1 and P
Topics: Animals; Aspartic Acid Endopeptidases; Brefeldin A; Carbonyl Cyanide m-Chlorophenyl Hydrazone; Cyclopentanes; Furin; Glycosylation; Hexosaminidases; Humans; In Vitro Techniques; Mice; Proprotein Convertase 1; Proprotein Convertase 2; Proprotein Convertases; Protein Precursors; Protein Processing, Post-Translational; Recombinant Proteins; Subtilisins; Sulfates; Tunicamycin | 1993 |
Connexin trafficking and the control of gap junction assembly in mouse preimplantation embryos.
Topics: Animals; Blastocyst; Blotting, Southern; Blotting, Western; Brefeldin A; Cell Fractionation; Cell Membrane; Connexin 43; Cyclopentanes; Cytoplasm; Intercellular Junctions; Mice; Mice, Inbred Strains; Monensin; Polymerase Chain Reaction; Polyribosomes; RNA, Messenger | 1993 |
Prevention of the induced synthesis and secretion of group II phospholipase A2 by brefeldin A.
Topics: Animals; Brefeldin A; Cells, Cultured; Cyclopentanes; Enzyme Induction; Fluorescent Antibody Technique; Glomerular Mesangium; Golgi Apparatus; Phospholipases A; Phospholipases A2; Protein Synthesis Inhibitors; Rats | 1993 |
Brefeldin A blocks the cytotoxicity of T cell receptor alpha/beta and gamma/delta cytotoxic T lymphocyte clones reacting against human autologous cancer cells.
Topics: Brefeldin A; Chloroquine; Colchicine; Cycloheximide; Cyclopentanes; Cytotoxicity Tests, Immunologic; Humans; Receptors, Antigen, T-Cell, alpha-beta; Receptors, Antigen, T-Cell, gamma-delta; T-Lymphocytes, Cytotoxic; Tumor Cells, Cultured | 1993 |
The actin-binding protein comitin (p24) is a component of the Golgi apparatus.
Topics: 3T3 Cells; Actins; Animals; Antibodies, Monoclonal; Antigens, Protozoan; Brefeldin A; Carrier Proteins; Cell Compartmentation; Cyclopentanes; Cytoskeleton; Dictyostelium; Dimethyl Sulfoxide; Fluorescent Antibody Technique; Fungal Proteins; Golgi Apparatus; Mice; Microfilament Proteins; Microtubules; Nocodazole; Protozoan Proteins; Recombinant Proteins | 1993 |
Alternate pathways of secretion of simian immunodeficiency virus envelope glycoproteins.
Topics: Brefeldin A; Cell Line; Cell Membrane; Cyclopentanes; Gene Products, env; HeLa Cells; Hexosaminidases; HIV Envelope Protein gp120; Humans; In Vitro Techniques; Membrane Glycoproteins; Monensin; Protein Processing, Post-Translational; Recombinant Proteins; Simian Immunodeficiency Virus; Viral Envelope Proteins | 1993 |
Tubulation of Golgi membranes in vivo and in vitro in the absence of brefeldin A.
Topics: Adenosine Triphosphate; Animals; Biological Transport; Brefeldin A; Coatomer Protein; Cyclopentanes; Golgi Apparatus; Intracellular Membranes; Liver; Male; Microscopy, Electron; Microtubule-Associated Proteins; Rats | 1993 |
Alpha- and beta-xylosides alter glycolipid synthesis in human melanoma and Chinese hamster ovary cells.
Topics: Animals; Anions; Brefeldin A; CHO Cells; Cricetinae; Cyclopentanes; G(M3) Ganglioside; Galactose; Glucuronidase; Glycolipids; Glycosides; Humans; Hymecromone; Macrophages; Melanoma; Neuroblastoma; PC12 Cells; Tritium; Tumor Cells, Cultured | 1993 |
Effects of brefeldin A on sphingomyelin transport and lipid synthesis in BHK21 cells.
Topics: Acetates; Animals; Biological Transport; Brefeldin A; Cells, Cultured; Colforsin; Cricetinae; Cyclopentanes; Lipids; Mycotoxins; Sphingomyelin Phosphodiesterase; Sphingomyelins | 1993 |
Involvement of the Golgi region in the intracellular trafficking of cholera toxin.
Topics: Animals; Brefeldin A; Cell Line; Cells, Cultured; Cholera Toxin; Cyclopentanes; Dipodomys; Golgi Apparatus; Kinetics; Mice | 1993 |
Differential effects of brefeldin A on transport of secretory and lysosomal proteins.
Topics: alpha 1-Antitrypsin; Biological Transport; Brefeldin A; Cathepsin D; Cell Compartmentation; Cyclopentanes; Endocytosis; Golgi Apparatus; Humans; In Vitro Techniques; Lysosomes; Protein Processing, Post-Translational; Secretory Rate; Subcellular Fractions; Tumor Cells, Cultured | 1993 |
beta-Amyloid peptide and a 3-kDa fragment are derived by distinct cellular mechanisms.
Topics: Ammonium Chloride; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Anti-Bacterial Agents; Base Sequence; Brefeldin A; Cell Line; Cell Membrane; Codon; Colchicine; Cyclopentanes; Golgi Apparatus; Humans; Kidney; Kinetics; Leupeptins; Molecular Sequence Data; Molecular Weight; Monensin; Oligodeoxyribonucleotides; Peptide Fragments; Sequence Deletion; Transfection | 1993 |
Brefeldin A causes a defect in secretion in Saccharomyces cerevisiae.
Topics: Antifungal Agents; Brefeldin A; Cyclopentanes; Fungal Proteins; Kinetics; Mutation; Saccharomyces cerevisiae; Species Specificity | 1993 |
Brefeldin A inhibits degradation as well as production and secretion of collagen in human lung fibroblasts.
Topics: Anti-Bacterial Agents; Brefeldin A; Cell Line; Collagen; Cyclopentanes; Dose-Response Relationship, Drug; Fetus; Fibroblasts; Golgi Apparatus; Humans; Kinetics; Lung; Microscopy, Electron; Protein Biosynthesis; Proteins | 1993 |
Effects of brefeldin A on cleavage of invariant chain to p21 and p10 and the appearance of Ii-freed class II MHC dimers.
Topics: Antigen-Presenting Cells; Antigens, Differentiation, B-Lymphocyte; Binding Sites; Brefeldin A; Cell Compartmentation; Cyclopentanes; Golgi Apparatus; Histocompatibility Antigens Class II; Leupeptins; Tumor Cells, Cultured | 1993 |
TGN38/41 recycles between the cell surface and the TGN: brefeldin A affects its rate of return to the TGN.
Topics: Animals; Brefeldin A; Cell Membrane; Cells, Cultured; Cyclopentanes; Endocytosis; Fluorescent Antibody Technique; Glycoproteins; Golgi Apparatus; Kinetics; Membrane Glycoproteins; Membrane Proteins; Microtubules; Rats | 1993 |
Brefeldin A reversibly inhibits secretion in Saccharomyces cerevisiae.
Topics: Antifungal Agents; beta-Fructofuranosidase; Brefeldin A; Cyclopentanes; Electrophoresis, Polyacrylamide Gel; Glycoside Hydrolases; Microbial Sensitivity Tests; Precipitin Tests; Saccharomyces cerevisiae | 1993 |
Effect of caffeine and reduced temperature (20 degrees C) on the organization of the pre-Golgi and the Golgi stack membranes.
Topics: Animals; Anti-Bacterial Agents; Biological Transport; Brefeldin A; Caffeine; Cell Line; Cricetinae; Cyclopentanes; Endoplasmic Reticulum; Golgi Apparatus; Intracellular Membranes; Kidney; Microscopy, Electron; Temperature | 1993 |
Regulation of acetylcholinesterase secretion from perfused bovine adrenal gland and isolated bovine chromaffin cells.
Topics: Acetylcholinesterase; Adrenal Glands; Animals; Brefeldin A; Cattle; Cell Separation; Chromaffin System; Cyclopentanes; Electric Stimulation; Isoflurophate; Microscopy, Electron; Perfusion | 1993 |
Characterization of two distinct pathways of endocytosis of ricin by rat liver endothelial cells.
Topics: Ammonium Chloride; Animals; Binding Sites; Biological Transport; Brefeldin A; Coated Pits, Cell-Membrane; Cyclopentanes; Endocytosis; Endothelium; Galactosides; Hydrogen-Ion Concentration; Lectins, C-Type; Liver; Lysosomes; Male; Mannose Receptor; Mannose-Binding Lectins; Monensin; Rats; Rats, Wistar; Receptors, Cell Surface; Receptors, Immunologic; Ricin | 1993 |
Brefeldin A reversibly blocks early but not late protein transport steps in the yeast secretory pathway.
Topics: Biological Transport; Brefeldin A; Carboxypeptidases; Cathepsin A; Cyclopentanes; Endoplasmic Reticulum; Fungal Proteins; Genes, Fungal; Genetic Complementation Test; Mating Factor; Mutation; Mycotoxins; Peptides; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins | 1993 |
Beta-COP localizes mainly to the cis-Golgi side in exocrine pancreas.
Topics: Aluminum; Aluminum Compounds; Animals; Biological Transport; Brefeldin A; Clathrin; Coatomer Protein; Cyclopentanes; Energy Metabolism; Fluorides; Golgi Apparatus; Male; Membrane Proteins; Microscopy, Immunoelectron; Microtubule-Associated Proteins; Pancreas; Rats; Rats, Wistar | 1993 |
Features of the polarity of the Golgi apparatus of frog photoreceptors: studies with lectins and with Brefeldin A.
Topics: Animals; Brefeldin A; Cyclopentanes; Golgi Apparatus; Lectins; Microscopy, Electron; Photoreceptor Cells; Rana pipiens | 1993 |
Recognition of vaccinia virus-encoded major histocompatibility complex class I antigens by virus immune cytotoxic T cells is independent of the polymorphism of the peptide transporters.
Topics: Animals; Biological Evolution; Brefeldin A; CD8 Antigens; Cell Line; Cyclopentanes; Cytotoxicity, Immunologic; Flow Cytometry; H-2 Antigens; HeLa Cells; Histocompatibility Antigens Class I; Humans; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Inbred CBA; Mice, Inbred Strains; Polymorphism, Genetic; Recombinant Proteins; Species Specificity; Spleen; T-Lymphocytes, Cytotoxic; Vaccinia virus; Vero Cells | 1993 |
Stimulation of acyl-CoA:cholesterol acyltransferase activity by brefeldin A in macrophage J774 cells.
Topics: Acetates; Animals; Anti-Bacterial Agents; Brefeldin A; Cell Line; Cholesterol; Cholesterol Esters; Cyclopentanes; Enzyme Activation; Macrophages; Mice; Oleic Acid; Oleic Acids; Sterol O-Acyltransferase | 1993 |
The rubella virus E2 and E1 spike glycoproteins are targeted to the Golgi complex.
Topics: Animals; Antigens, Viral; Brefeldin A; Chlorocebus aethiops; CHO Cells; Cricetinae; Cyclopentanes; Glycoproteins; Golgi Apparatus; Models, Biological; Nocodazole; Rubella virus; Vero Cells; Viral Envelope Proteins | 1993 |
Inhibition of apolipoprotein E degradation in a post-Golgi compartment by a cysteine protease inhibitor.
Topics: Albumins; Ammonium Chloride; Animals; Apolipoproteins E; Brefeldin A; Calcium; Cathepsin B; Cathepsin L; Cathepsins; Chloroquine; CHO Cells; Cricetinae; Cyclopentanes; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Endopeptidases; Golgi Apparatus; Humans; Kinetics; Leupeptins; Molecular Sequence Data; Transfection; Tumor Cells, Cultured | 1993 |
Intracellular retention and degradation of human mutant variant of a alpha 1-antitrypsin in stably transfected Chinese hamster ovary cell lines.
Topics: alpha 1-Antitrypsin; Animals; Base Sequence; Biological Transport; Brefeldin A; Cell Line; CHO Cells; Cricetinae; Cyclopentanes; Endoplasmic Reticulum; Glycosylation; Golgi Apparatus; Humans; Molecular Sequence Data; Monensin; Oligodeoxyribonucleotides; Plasmids; Transfection; Tunicamycin | 1993 |
Studies on the cellular pathway involved in assembly of the embryonic sea urchin spicule.
Topics: Animals; Brefeldin A; Calcium; Calcium Channel Blockers; Cells, Cultured; Cyclopentanes; Endoplasmic Reticulum; Golgi Apparatus; In Vitro Techniques; Membrane Glycoproteins; Mesoderm; Monensin; Morphogenesis; Sea Urchins | 1993 |
Activation of ADP-ribosylation factor by Golgi membranes. Evidence for a brefeldin A- and protease-sensitive activating factor on Golgi membranes.
Topics: ADP-Ribosylation Factors; Amino Acid Sequence; Animals; Brain; Brefeldin A; Carrier Proteins; Cattle; Centrifugation, Density Gradient; CHO Cells; Cholera Toxin; Cricetinae; Cyclopentanes; Dimyristoylphosphatidylcholine; Endopeptidases; Endoplasmic Reticulum; Golgi Apparatus; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Diphosphate; Guanosine Triphosphate; Humans; Kinetics; Liver; Molecular Sequence Data; Myristic Acid; Myristic Acids; NAD; Peptides; Rats; Recombinant Proteins | 1993 |
Kinetic and spatial interrelationships between ganglioside glycosyltransferases and O-acetyltransferase(s) in human melanoma cells.
Topics: Acetyltransferases; Brefeldin A; Chromatography, High Pressure Liquid; Chromatography, Ion Exchange; Chromatography, Thin Layer; Cyclopentanes; Cytidine Monophosphate N-Acetylneuraminic Acid; Galactose; Gangliosides; Glycosyltransferases; Golgi Apparatus; Humans; Kinetics; Lipid Metabolism; Lipids; Melanoma; Models, Biological; Radioisotope Dilution Technique; Tumor Cells, Cultured; Uridine Diphosphate N-Acetylglucosamine | 1993 |
A cytotoxic ribonuclease. Study of the mechanism of onconase cytotoxicity.
Topics: Animals; Antineoplastic Agents; Autoradiography; Blotting, Northern; Brefeldin A; Cell Survival; Cyclopentanes; Dose-Response Relationship, Drug; Egg Proteins; Embryo, Nonmammalian; Glioma; Kinetics; Leucine; Neoplasm Proteins; Oocytes; Placental Hormones; Protein Synthesis Inhibitors; Rana pipiens; Ribonuclease, Pancreatic; Ribonucleases; RNA, Messenger; Tumor Cells, Cultured; Tumor Stem Cell Assay | 1993 |
Isolation of a temperature-sensitive variant Chinese hamster ovary cell line with a morphologically altered endocytic recycling compartment.
Topics: Animals; Brefeldin A; CHO Cells; Cricetinae; Cyclopentanes; Cytoskeleton; Diphtheria Toxin; Endocytosis; Ethyl Methanesulfonate; Fluorescent Antibody Technique; Golgi Apparatus; Kinetics; Lipoproteins, LDL; Microtubules; Mutagenesis; Phenotype; Ricin; Temperature; Transferrin | 1993 |
Effects of brefeldin A and accessory proteins on association of ADP-ribosylation factors 1, 3, and 5 with Golgi.
Topics: ADP-Ribosylation Factor 1; ADP-Ribosylation Factors; Animals; Brain; Brefeldin A; Carrier Proteins; Chromatography, Ion Exchange; Cyclopentanes; Electrophoresis, Polyacrylamide Gel; Golgi Apparatus; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Kinetics; Nerve Tissue Proteins; Rats | 1993 |
Class I molecules retained in the endoplasmic reticulum bind antigenic peptides.
Topics: Animals; Antigens, Viral; Brefeldin A; Cell Line; Cyclopentanes; Endoplasmic Reticulum; Exocytosis; Hemagglutinin Glycoproteins, Influenza Virus; Hemagglutinins, Viral; Histocompatibility Antigens Class I; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Nucleocapsid Proteins; Nucleoproteins; Peptides; RNA-Binding Proteins; Viral Core Proteins | 1993 |
Release of stress proteins from Mesocestoides corti is a brefeldin A-inhibitable process: evidence for active export of stress proteins.
Topics: Animals; Anti-Bacterial Agents; Biological Transport, Active; Brefeldin A; Cyclopentanes; Heat-Shock Proteins; Mesocestoides; Mice; Mice, Inbred BALB C | 1993 |
Apical secretion of a cytosolic protein by Madin-Darby canine kidney cells. Evidence for polarized release of an endogenous lectin by a nonclassical secretory pathway.
Topics: Animals; Brefeldin A; Calcimycin; Cell Line; Chromatography, Affinity; Cyclopentanes; Cysteine; Cytosol; Dogs; Electrophoresis, Polyacrylamide Gel; Immunohistochemistry; Kidney; Kinetics; L-Lactate Dehydrogenase; Lectins; Methionine; Methylamines; Molecular Weight; Monensin; Nocodazole; Sulfur Radioisotopes; Temperature; Verapamil | 1993 |
Disruption of endoplasmic reticulum to Golgi transport leads to the accumulation of large aggregates containing beta-COP in pancreatic acinar cells.
Topics: Adenosine Triphosphate; Animals; Brefeldin A; Coatomer Protein; Cyclopentanes; Cytoplasm; Electrophoresis, Polyacrylamide Gel; Endoplasmic Reticulum; Female; Golgi Apparatus; Immunohistochemistry; Male; Membrane Proteins; Mice; Microscopy, Electron; Microtubule-Associated Proteins; Pancreas; Rats; Rats, Sprague-Dawley | 1993 |
Correlation between phospholipase A2 activity and intra-Golgi protein transport reconstituted in a cell-free system.
Topics: Acetylglucosamine; Animals; Biological Transport; Brefeldin A; Cell-Free System; Cells, Cultured; Cyclopentanes; Fatty Acids; Golgi Apparatus; Masoprocol; Membrane Glycoproteins; ortho-Aminobenzoates; Phospholipases A; Phospholipases A2; Prolactin; Viral Envelope Proteins | 1993 |
Cerulenin inhibits the cytotoxicity of ricin, modeccin, Pseudomonas toxin, and diphtheria toxin in brefeldin A-resistant cell lines.
Topics: ADP Ribose Transferases; Animals; Bacterial Toxins; Brefeldin A; Cell Death; Cell Line; Cerulenin; Cyclopentanes; Diphtheria Toxin; Drug Resistance; Endocytosis; Ethyl Methanesulfonate; Exotoxins; Lectins; Models, Biological; Mutagenesis; Plant Lectins; Pseudomonas aeruginosa Exotoxin A; Ribosome Inactivating Proteins, Type 2; Ricin; Toxins, Biological; Vero Cells; Virulence Factors | 1993 |
Complete vesiculation of Golgi membranes and inhibition of protein transport by a novel sea sponge metabolite, ilimaquinone.
Topics: Animals; Biological Transport; Brefeldin A; Cells, Cultured; CHO Cells; Coatomer Protein; Cricetinae; Cyclopentanes; Golgi Apparatus; GTP-Binding Proteins; Intracellular Membranes; Microtubule-Associated Proteins; Porifera; Quinones | 1993 |
Early and late transformations occurring at organelles of the Golgi area under the influence of brefeldin A: an ultrastructural and lectin cytochemical study.
Topics: Brefeldin A; Cell Line; Cyclopentanes; Endoplasmic Reticulum; Golgi Apparatus; Histocytochemistry; Humans; Lectins; Microscopy, Electron; Mycotoxins; Time Factors; Tumor Cells, Cultured | 1993 |
Axon membrane flows from the growth cone to the cell body.
Topics: Animals; Axonal Transport; Axons; Biological Transport; Brefeldin A; Cell Membrane; Chick Embryo; Cyclopentanes; Cytoskeleton; Ganglia, Spinal; Immunoglobulin G; Lasers; Microspheres; Phosphatidylethanolamines; Rats | 1995 |
Cytoplasmic coat proteins involved in endosome function.
Topics: ADP-Ribosylation Factors; Animals; Biological Transport; Brefeldin A; Cell Fractionation; Chlorocebus aethiops; CHO Cells; Clathrin; Coated Pits, Cell-Membrane; Coatomer Protein; Cricetinae; Cyclopentanes; Endosomes; Golgi Apparatus; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Horseradish Peroxidase; Humans; Intracellular Membranes; Membrane Glycoproteins; Membrane Proteins; Microtubule-Associated Proteins; Transferrin; Vero Cells; Vesicular stomatitis Indiana virus; Viral Envelope Proteins | 1995 |
Gap junction turnover, intracellular trafficking, and phosphorylation of connexin43 in brefeldin A-treated rat mammary tumor cells.
Topics: Animals; Antifungal Agents; Brefeldin A; Cell Line; Connexin 43; Cycloheximide; Cyclopentanes; Endoplasmic Reticulum; Gap Junctions; Golgi Apparatus; Isomerases; Kinetics; Mammary Neoplasms, Animal; Phosphorylation; Protein Biosynthesis; Protein Disulfide-Isomerases; Protein Synthesis Inhibitors; Rats; Receptors, Cell Surface; Receptors, Fibroblast Growth Factor; Sialoglycoproteins; Tumor Cells, Cultured; Uncoupling Agents | 1995 |
Evidence for ADP-ribosylation-factor-mediated activation of phospholipase D by m3 muscarinic acetylcholine receptor.
Topics: ADP-Ribosylation Factors; Brefeldin A; Cell Line; Cyclopentanes; Enzyme Activation; GTP-Binding Proteins; Humans; Phospholipase D; Protein Binding; Receptor, Muscarinic M3; Receptors, Muscarinic; Signal Transduction | 1995 |
The effects of brefeldin A on the glucose transport system in rat adipocytes. Implications regarding the intracellular locus of insulin-sensitive Glut4.
Topics: 3-O-Methylglucose; Adipocytes; Adipose Tissue; Animals; Biological Transport; Brefeldin A; Cell Membrane; Cells, Cultured; Cyclopentanes; Deoxyglucose; Epididymis; Glucose; Glucose Transporter Type 4; Golgi Apparatus; Humans; Insulin; Kinetics; Male; Methylglucosides; Monosaccharide Transport Proteins; Muscle Proteins; Protein Synthesis Inhibitors; Rats; Rats, Sprague-Dawley; Recombinant Proteins | 1995 |
The ARF1 GTPase-activating protein: zinc finger motif and Golgi complex localization.
Topics: ADP-Ribosylation Factor 1; ADP-Ribosylation Factors; Alternative Splicing; Amino Acid Sequence; Animals; Base Sequence; Brefeldin A; Cloning, Molecular; Cyclopentanes; Cytosol; DNA, Complementary; Golgi Apparatus; GTP-Binding Proteins; GTPase-Activating Proteins; Guanosine Triphosphate; Liver; Molecular Sequence Data; Proteins; Rats; Zinc Fingers | 1995 |
Growth inhibitory action of brefeldin A with taxol and tiazofurin in human breast carcinoma cells.
Topics: Anti-Bacterial Agents; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Brefeldin A; Cell Division; Cyclopentanes; Drug Synergism; Humans; Macrolides; Paclitaxel; Ribavirin; Tumor Cells, Cultured | 1995 |
COPI- and COPII-coated vesicles bud directly from the endoplasmic reticulum in yeast.
Topics: Anti-Bacterial Agents; Biological Transport; Brefeldin A; Coated Vesicles; Coatomer Protein; Cyclopentanes; Endoplasmic Reticulum; Macrolides; Membrane Proteins; Microscopy, Immunoelectron; Nuclear Envelope; Yeasts | 1995 |
Retinol binding protein and transthyretin are secreted as a complex formed in the endoplasmic reticulum in HepG2 human hepatocarcinoma cells.
Topics: Brefeldin A; Calcium-Binding Proteins; Calnexin; Carcinoma, Hepatocellular; Cross-Linking Reagents; Cyclopentanes; Detergents; Endoplasmic Reticulum; Glucosides; Humans; Liver; Microsomes, Liver; Molecular Chaperones; Molecular Weight; Prealbumin; Precipitin Tests; Protein Synthesis Inhibitors; Retinol-Binding Proteins; Succinimides; Tumor Cells, Cultured | 1996 |
The envelope glycoprotein of human immunodeficiency virus type 2 enhances viral particle release: a Vpu-like factor?
Topics: Brefeldin A; Cyclopentanes; Gene Products, nef; Gene Products, vif; Gene Products, vpr; Genes, Viral; Glycoproteins; HIV Seropositivity; HIV-2; Human Immunodeficiency Virus Proteins; Humans; Mutation; nef Gene Products, Human Immunodeficiency Virus; vif Gene Products, Human Immunodeficiency Virus; Viral Envelope Proteins; Viral Regulatory and Accessory Proteins; Virion; vpr Gene Products, Human Immunodeficiency Virus | 1996 |
Events in the endoplasmic reticulum abrogate the temperature sensitivity of Sindbis virus mutant ts23.
Topics: Animals; Brefeldin A; Cell Line; Cyclopentanes; Endoplasmic Reticulum; Golgi Apparatus; Membrane Fusion; Membrane Glycoproteins; Monensin; Mutation; Sindbis Virus; Temperature; Viral Envelope Proteins; Virus Assembly | 1996 |
Glucose induces amphiphilic to hydrophilic conversion of a subset of glycosyl-phosphatidylinositol-anchored ectoproteins in yeast.
Topics: Biological Transport; Brefeldin A; Carrier Proteins; Cyclopentanes; Glucose; Glycosylphosphatidylinositols; Membrane Glycoproteins; Phospholipases; Protein Conformation; Protein Processing, Post-Translational; Protein Synthesis Inhibitors; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Signal Transduction; Spheroplasts | 1995 |
Synthesis and processing of hydrophobic surfactant protein C by isolated rat type II cells.
Topics: Animals; Blotting, Western; Brefeldin A; Cell Separation; Cells, Cultured; Cyclopentanes; Immunohistochemistry; Kinetics; Peptide Fragments; Protein Processing, Post-Translational; Protein Synthesis Inhibitors; Proteolipids; Pulmonary Alveoli; Pulmonary Surfactants; Rats; Rats, Sprague-Dawley | 1995 |
Insulin-mediated inhibition of apolipoprotein B secretion requires an intracellular trafficking event and phosphatidylinositol 3-kinase activation: studies with brefeldin A and wortmannin in primary cultures of rat hepatocytes.
Topics: Androstadienes; Animals; Apolipoproteins B; Biological Transport; Brefeldin A; Cells, Cultured; Cyclopentanes; Enzyme Activation; Enzyme Inhibitors; Hydrolysis; Insulin; Liver; Phosphatidylinositol 3-Kinases; Phosphotransferases (Alcohol Group Acceptor); Rats; Rats, Sprague-Dawley; Wortmannin | 1996 |
Ionic milieu controls the compartment-specific activation of pro-opiomelanocortin processing in AtT-20 cells.
Topics: Adrenocorticotropic Hormone; Animals; Anti-Bacterial Agents; Aspartic Acid Endopeptidases; Biological Transport; Brefeldin A; Calcium; Cell Compartmentation; Cell Line; Cyclopentanes; Cytoplasmic Granules; Endoplasmic Reticulum; Ethylmaleimide; Golgi Apparatus; Hydrogen-Ion Concentration; Macrolides; Mice; Pituitary Gland, Anterior; Pro-Opiomelanocortin; Proprotein Convertase 1; Proprotein Convertases; Protein Processing, Post-Translational; Proton-Translocating ATPases | 1995 |
Pericentriolar targeting of GDP-dissociation inhibitor isoform 2.
Topics: 3T3 Cells; Adipose Tissue; Amino Acid Sequence; Animals; Antigens; Biological Transport; Brefeldin A; Cell Differentiation; Cell Line, Transformed; Centrioles; Centrosome; Chlorocebus aethiops; CHO Cells; Cricetinae; Cricetulus; Cyclopentanes; Cytosol; Detergents; Endocytosis; Fibroblasts; Golgi Apparatus; GTP-Binding Proteins; Guanine Nucleotide Dissociation Inhibitors; Interphase; Intracellular Membranes; Mice; Microscopy, Fluorescence; Mitosis; Molecular Sequence Data; Nocodazole; Octoxynol; Proto-Oncogene Proteins c-myc; rab3 GTP-Binding Proteins; Recombinant Fusion Proteins; Transfection | 1995 |
Differential response of resident proteins and cycling proteins of the Golgi to brefeldin A.
Topics: Animals; Biological Transport; Biomarkers; Brefeldin A; Cells, Cultured; Cyclopentanes; Endoplasmic Reticulum; Exocytosis; Golgi Apparatus; Kidney; Kinetics; Liver; Mannosidases; Membrane Proteins; Microtubules; Proteins; Rats; Receptors, Peptide | 1995 |
Myristoylation-facilitated binding of the G protein ARF1GDP to membrane phospholipids is required for its activation by a soluble nucleotide exchange factor.
Topics: ADP-Ribosylation Factor 1; ADP-Ribosylation Factors; Animals; Brefeldin A; Carrier Proteins; Cattle; Cell Membrane; Cyclopentanes; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Diphosphate; Guanosine Triphosphate; Kinetics; Liposomes; Magnesium; Membrane Lipids; Myristic Acid; Myristic Acids; Phospholipids; Protein Processing, Post-Translational; Protein Synthesis Inhibitors; Recombinant Proteins; Rod Cell Outer Segment; Trypsin | 1996 |
Heterologous expression of apolipoprotein B carboxyl-terminal truncates: a model for the study of lipoprotein biogenesis.
Topics: Amino Acid Sequence; Apolipoproteins B; Brefeldin A; Cell Line; Cyclopentanes; Lipoproteins; Models, Biological; Molecular Sequence Data; Oleic Acid; Oleic Acids | 1995 |
Lysosomal degradation and sorting of apolipoprotein E in macrophages.
Topics: Animals; Apolipoproteins E; Brefeldin A; Cells, Cultured; Cyclopentanes; Cysteine Endopeptidases; Endoplasmic Reticulum; Golgi Apparatus; Hydroxycholesterols; Lysosomes; Macrophages, Peritoneal; Male; Mice; Microscopy, Electron; Microscopy, Fluorescence; Protease Inhibitors; Protein Processing, Post-Translational | 1995 |
O-glycosylation of a precursor to a sweet potato vacuolar protein, sporamin, expressed in tobacco cells.
Topics: 2,2'-Dipyridyl; Amino Acid Sequence; Base Sequence; Brefeldin A; Calcimycin; Carbohydrates; Cell Line; Cyclopentanes; DNA Primers; Glycoproteins; Glycosylation; Golgi Apparatus; Molecular Sequence Data; Monensin; Mutagenesis, Site-Directed; Nicotiana; Peptide Fragments; Plant Proteins; Plants, Toxic; Point Mutation; Proline; Protein Precursors; Protein Processing, Post-Translational; Protein Sorting Signals; Protein Synthesis Inhibitors; Recombinant Proteins; Serine; Transfection; Vacuoles; Vegetables | 1995 |
Drugs that show protective effects from ricin toxicity in in vitro protein synthesis assays.
Topics: Animals; Antimetabolites; Brefeldin A; Carbohydrate Sequence; Chlorocebus aethiops; Cyclopentanes; Drug Synergism; Galactose; Imidazoles; In Vitro Techniques; Lactose; Molecular Sequence Data; Protein Synthesis Inhibitors; Reticulocytes; Ricin; Structure-Activity Relationship; Vero Cells; Zidovudine | 1995 |
Low-efficiency (macro-)pinocytic internalization of non-pathogenic Escherichia coli into HEp-2 cells.
Topics: Antifungal Agents; Antineoplastic Agents; Brefeldin A; Cadaverine; Cyclopentanes; Endocytosis; Epithelial Cells; Epithelium; Escherichia coli; In Vitro Techniques; Microscopy, Electron; Microscopy, Fluorescence; Microtubules; Pinocytosis; Protein-Tyrosine Kinases; Xanthenes | 1995 |
Low-level doxorubicin resistance in P-glycoprotein-negative human pancreatic tumour PSN1/ADR cells implicates a brefeldin A-sensitive mechanism of drug extrusion.
Topics: Antibiotics, Antineoplastic; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Brefeldin A; Cyclopentanes; Doxorubicin; Drug Resistance, Multiple; Flow Cytometry; GTP-Binding Proteins; Humans; Pancreatic Neoplasms; Tumor Cells, Cultured; Verapamil | 1996 |
Chlamydia trachomatis interrupts an exocytic pathway to acquire endogenously synthesized sphingomyelin in transit from the Golgi apparatus to the plasma membrane.
Topics: 4-Chloro-7-nitrobenzofurazan; Animals; Anti-Bacterial Agents; Biological Transport, Active; Brefeldin A; Cell Membrane; Ceramides; Chlamydia Infections; Chlamydia trachomatis; Cyclopentanes; Exocytosis; Fluorescent Dyes; Golgi Apparatus; HeLa Cells; Humans; Inclusion Bodies; Macrolides; Membrane Fusion; Microscopy, Electron; Models, Biological; Sphingomyelins | 1996 |
Aggregation of the inactive form of human alpha-galactosidase in the endoplasmic reticulum.
Topics: alpha-Galactosidase; Animals; Blotting, Western; Brefeldin A; Cell Line; Chlorocebus aethiops; Cyclopentanes; Electrophoresis, Polyacrylamide Gel; Endoplasmic Reticulum; Humans; Kidney; Macromolecular Substances; Monensin; Mutagenesis, Site-Directed; Point Mutation; Protein Synthesis Inhibitors; Recombinant Proteins; Sulfur Radioisotopes; Transfection | 1996 |
Cab45, a novel (Ca2+)-binding protein localized to the Golgi lumen.
Topics: 3T3 Cells; Adipocytes; Amino Acid Sequence; Animals; Base Sequence; Brefeldin A; Calcium-Binding Proteins; Cloning, Molecular; Cyclopentanes; DNA, Complementary; Gene Expression; Glycoproteins; Glycosylation; Golgi Apparatus; Mice; Molecular Sequence Data; Molecular Weight; Protein Synthesis Inhibitors; Recombinant Fusion Proteins; RNA, Messenger; Sequence Analysis, DNA | 1996 |
Intracellular interaction of collagen-specific stress protein HSP47 with newly synthesized procollagen.
Topics: 2,2'-Dipyridyl; Amino Acid Sequence; Ammonia-Lyases; Animals; Ascorbic Acid; Base Sequence; Biological Transport; Brefeldin A; Cells, Cultured; Chick Embryo; Cyclopentanes; Endoplasmic Reticulum; Fibroblasts; Golgi Apparatus; Heat-Shock Proteins; HSP47 Heat-Shock Proteins; Intracellular Membranes; Iron Chelating Agents; Membrane Proteins; Mice; Molecular Sequence Data; Procollagen; Protein Synthesis Inhibitors; Sequence Deletion | 1996 |
Effect of brefeldin A on rotavirus assembly and oligosaccharide processing.
Topics: Amino Acid Sequence; Animals; Antigens, Viral; Antiviral Agents; Biological Transport; Brefeldin A; Capsid; Cells, Cultured; Cyclopentanes; Endoplasmic Reticulum; Enzyme Inhibitors; Glycosylation; Hemagglutinins, Viral; Hexosaminidases; Mannosyl-Glycoprotein Endo-beta-N-Acetylglucosaminidase; Molecular Sequence Data; Morphogenesis; Protein Processing, Post-Translational; Rotavirus; Tunicamycin; Virus Replication | 1996 |
Comparative study of the metabolic pools of sphingomyelin and phosphatidylcholine sensitive to tumor necrosis factor.
Topics: Brefeldin A; Cell Compartmentation; Cell Membrane; Cells, Cultured; Cyclopentanes; Fibroblasts; Humans; Ionophores; Membrane Lipids; Monensin; Phosphatidylcholines; Signal Transduction; Sphingomyelins; Tumor Necrosis Factor-alpha | 1996 |
Ceramides are transported through the Golgi apparatus in human keratinocytes in vitro.
Topics: Biological Transport; Brefeldin A; Cell Membrane; Cells, Cultured; Ceramides; Cyclopentanes; Golgi Apparatus; Humans; Keratinocytes; Monensin | 1996 |
Fusion of a signal sequence to the interleukin-1 beta gene directs the protein from cytoplasmic accumulation to extracellular release.
Topics: 3T3 Cells; Animals; Base Sequence; Brefeldin A; Cell Death; Cyclopentanes; Cytoplasm; Extracellular Space; Genetic Vectors; Glycosylation; Interleukin-1; Mice; Molecular Sequence Data; Molecular Weight; Protein Precursors; Protein Synthesis Inhibitors; Recombinant Fusion Proteins; Retroviridae; RNA, Messenger; Staining and Labeling; Transfection | 1996 |
Characterization of a nuclear protein conferring brefeldin A resistance in Schizosaccharomyces pombe.
Topics: Amino Acid Sequence; Antifungal Agents; Base Sequence; Brefeldin A; Cell Compartmentation; Consensus Sequence; Cyclopentanes; DNA Primers; Drug Resistance, Microbial; Fungal Proteins; Genes, Fungal; Golgi Apparatus; GTP-Binding Proteins; Molecular Sequence Data; Nuclear Proteins; Phosphoproteins; ran GTP-Binding Protein; Restriction Mapping; Schizosaccharomyces; Sequence Alignment; Sequence Homology, Amino Acid | 1996 |
Porcine submaxillary mucin forms disulfide-bonded dimers between its carboxyl-terminal domains.
Topics: Animals; Base Sequence; Brefeldin A; Cell Line; Chlorocebus aethiops; Chromatography, Gel; Cyclopentanes; Disulfides; Endoplasmic Reticulum; Glycosylation; Macromolecular Substances; Molecular Sequence Data; Molecular Weight; Mucins; Mutagenesis, Site-Directed; Oligosaccharides; Recombinant Proteins; Submandibular Gland; Sulfur Radioisotopes; Swine; Transfection; Tunicamycin | 1996 |
Biosynthesis and processing of proteinase 3 in U937 cells. Processing pathways are distinct from those of cathepsin G.
Topics: Amino Acid Sequence; Ammonium Chloride; Animals; Autoradiography; Brefeldin A; Cathepsin C; Cathepsin G; Cathepsins; Cell Line; Chloroquine; Cricetinae; Cyclopentanes; Dipeptidyl-Peptidases and Tripeptidyl-Peptidases; Electrophoresis, Polyacrylamide Gel; Enzyme Precursors; Humans; Isoleucine; Methionine; Molecular Sequence Data; Myeloblastin; Neutrophils; Peptide Fragments; Protein Processing, Post-Translational; Protein Synthesis Inhibitors; Sequence Homology, Amino Acid; Serine Endopeptidases; Sulfur Radioisotopes; Tritium | 1996 |
Concanamycin A, a powerful tool for characterization and estimation of contribution of perforin- and Fas-based lytic pathways in cell-mediated cytotoxicity.
Topics: Animals; Anti-Bacterial Agents; Brefeldin A; CD4-Positive T-Lymphocytes; CD8-Positive T-Lymphocytes; Clone Cells; Cyclopentanes; Cytotoxicity, Immunologic; Drug Combinations; Epitopes; fas Receptor; Female; Macrolides; Membrane Glycoproteins; Mice; Mice, Inbred BALB C; Mice, Inbred C3H; Mice, Inbred C57BL; Perforin; Pore Forming Cytotoxic Proteins; Proton-Translocating ATPases; T-Lymphocytes, Cytotoxic | 1996 |
Evidence that syntaxin 1A is involved in storage in the secretory pathway.
Topics: Animals; Antigens, Surface; Botulinum Toxins; Brefeldin A; Cell Line; Cell Membrane; Chlorocebus aethiops; Cycloheximide; Cyclopentanes; Cytoplasmic Granules; Fluorescent Antibody Technique, Indirect; Gene Expression; Growth Hormone; Humans; Kidney; Kinetics; Metallothionein; Mice; Nerve Tissue Proteins; Neurotoxins; Promoter Regions, Genetic; Protein Synthesis Inhibitors; Recombinant Proteins; Syntaxin 1; Transfection; Vesicular stomatitis Indiana virus | 1996 |
Transport and processing of the Rous sarcoma virus Gag protein in the endoplasmic reticulum.
Topics: Amino Acid Sequence; Animals; Aspartic Acid Endopeptidases; Avian Sarcoma Viruses; Base Sequence; Biological Transport; Brefeldin A; Cell Line; Cell Membrane; Cyclopentanes; DNA, Viral; Endoplasmic Reticulum; Gene Products, env; Gene Products, gag; Glycosylation; Mice; Molecular Sequence Data; Protein Processing, Post-Translational; Recombinant Fusion Proteins; Trypsin | 1996 |
Selective degradation of accumulated secretory proteins in the endoplasmic reticulum. A possible clearance pathway for abnormal tropoelastin.
Topics: Ammonium Chloride; Animals; Blotting, Northern; Brefeldin A; Cattle; Cells, Cultured; Cycloheximide; Cyclopentanes; Endoplasmic Reticulum; Leucine; Leupeptins; Ligaments; Microscopy, Electron; Nocodazole; Organelles; Protein Synthesis Inhibitors; RNA, Messenger; Serine Proteinase Inhibitors; Transcription, Genetic; Tropoelastin | 1996 |
A mutant cytochrome b5 with a lengthened membrane anchor escapes from the endoplasmic reticulum and reaches the plasma membrane.
Topics: Amino Acid Sequence; Animals; Base Sequence; Brefeldin A; Cell Line; Cell Membrane; Chlorocebus aethiops; Cloning, Molecular; Cycloheximide; Cyclopentanes; Cytochromes b5; DNA Primers; Dogs; Endoplasmic Reticulum; Molecular Sequence Data; Mutagenesis, Insertional; Polymerase Chain Reaction; Protein Synthesis Inhibitors; Recombinant Proteins; Transfection | 1996 |
Glycosylation and phosphorylation of lysosomal glycosylasparaginase.
Topics: Animals; Aspartylglucosylaminase; Base Sequence; Biological Transport; Brefeldin A; Cyclopentanes; Glycosylation; Humans; Lysosomes; Molecular Sequence Data; Mutagenesis, Site-Directed; Mutation; Oligosaccharides; Phosphorylation; Polymerase Chain Reaction; Protein Folding; Protein Processing, Post-Translational; Protein Synthesis Inhibitors; Recombinant Proteins | 1996 |
Mycobacterium avium- and Mycobacterium tuberculosis-containing vacuoles are dynamic, fusion-competent vesicles that are accessible to glycosphingolipids from the host cell plasmalemma.
Topics: Animals; Bone Marrow; Brefeldin A; Cell Compartmentation; Cell Membrane; Cholera Toxin; Cyclopentanes; Endocytosis; Glycosphingolipids; Immunohistochemistry; Macrophages; Membrane Fusion; Mice; Mice, Inbred BALB C; Mycobacterium avium; Mycobacterium tuberculosis; Vacuoles | 1996 |
Down-regulation of secretion of human complement component C2 by the product of an alternatively spliced C2 messenger RNA.
Topics: Alternative Splicing; Animals; Base Sequence; Brefeldin A; Cell Compartmentation; Cells, Cultured; Chlorocebus aethiops; Complement C2; Cyclopentanes; Down-Regulation; Fluorescent Antibody Technique, Indirect; Gene Expression; Humans; Molecular Sequence Data; Oligodeoxyribonucleotides; RNA, Messenger | 1996 |
Folding, assembly, and intracellular trafficking of the human immunodeficiency virus type 1 envelope glycoprotein analyzed with monoclonal antibodies recognizing maturational intermediates.
Topics: Animals; Antibodies, Monoclonal; Brefeldin A; Carrier Proteins; CD4 Antigens; Cyclopentanes; Endoplasmic Reticulum Chaperone BiP; Gene Products, env; Heat-Shock Proteins; HIV Envelope Protein gp160; HIV-1; Mice; Molecular Chaperones; Protein Folding; Protein Precursors; Temperature; Virus Assembly | 1996 |
Alloreactive CD4+ T lymphocytes can exert cytotoxicity to chronic myeloid leukaemia cells processing and presenting exogenous antigen.
Topics: Bone Marrow Transplantation; Brefeldin A; CD4-Positive T-Lymphocytes; Chloroquine; Cyclopentanes; Cytotoxicity, Immunologic; fas Receptor; Graft vs Host Reaction; Histocompatibility Antigens Class II; HLA-DR Antigens; Humans; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Protein Synthesis Inhibitors | 1996 |
Ecto-sialyltransferase of human B lymphocytes reconstitutes differentiation markers in the presence of exogenous CMP-N-acetyl neuraminic acid.
Topics: Antigens, CD; Antigens, Differentiation, B-Lymphocyte; B-Lymphocytes; beta-D-Galactoside alpha 2-6-Sialyltransferase; beta-Galactoside alpha-2,3-Sialyltransferase; Brefeldin A; Chloroquine; Culture Media, Conditioned; Cyclopentanes; Cytidine Monophosphate N-Acetylneuraminic Acid; Enzyme Inhibitors; Glycosylation; HLA-D Antigens; Humans; Membrane Glycoproteins; Neoplasm Proteins; Neuraminic Acids; Protein Processing, Post-Translational; Receptors, Antigen, B-Cell; Receptors, Transferrin; Sialyltransferases; Tumor Cells, Cultured | 1996 |
Programmed cell death in the anuran tadpole tail requires expression of a cell surface glycoprotein.
Topics: Animals; Apoptosis; Brefeldin A; Carbohydrates; Cell Membrane; Concanavalin A; Cyclopentanes; Fucose; Membrane Glycoproteins; Metamorphosis, Biological; Neuraminidase; Organ Culture Techniques; Protein Synthesis Inhibitors; Rana catesbeiana; Tail; Triiodothyronine; Tunicamycin | 1996 |
Lysosomal alpha-glucosidase: cell-specific processing and altered maturation in HT-29 colon cancer cells.
Topics: alpha-Glucosidases; Amidohydrolases; Ammonia; Brefeldin A; Caco-2 Cells; Cell Membrane; Colonic Neoplasms; Cyclopentanes; Endosomes; Glycosylation; Golgi Apparatus; Hexosaminidases; HT29 Cells; Humans; Lysosomes; N-Acetylneuraminic Acid; Pancreas; Peptide-N4-(N-acetyl-beta-glucosaminyl) Asparagine Amidase; Protease Inhibitors; Protein Processing, Post-Translational; Sialic Acids; Temperature; Tumor Cells, Cultured | 1996 |
Syncytia formation induced by coronavirus infection is associated with fragmentation and rearrangement of the Golgi apparatus.
Topics: Animals; Antiviral Agents; Brefeldin A; Cell Line; Cyclopentanes; Defective Viruses; Endoplasmic Reticulum, Rough; Giant Cells; Golgi Apparatus; Mice; Microtubules; Murine hepatitis virus; Mutation | 1996 |
The microsomal triglyceride transfer protein facilitates assembly and secretion of apolipoprotein B-containing lipoproteins and decreases cotranslational degradation of apolipoprotein B in transfected COS-7 cells.
Topics: Animals; Apolipoproteins B; Brefeldin A; Carrier Proteins; Cell Line; Chlorocebus aethiops; Cholesterol Ester Transfer Proteins; Cyclopentanes; Glycerol; Glycoproteins; Humans; Kidney; Kinetics; Macromolecular Substances; Microsomes; Oleic Acid; Oleic Acids; Phosphatidylcholines; Protein Biosynthesis; Protein Synthesis Inhibitors; Rats; Recombinant Proteins; Transfection; Triglycerides | 1996 |
Intracellular events in the "selective" transport of lipoprotein-derived cholesteryl esters.
Topics: Adenosine Triphosphatases; Animals; Apolipoproteins E; Azides; Biological Transport; Boron Compounds; Brefeldin A; Bucladesine; Carbonyl Cyanide m-Chlorophenyl Hydrazone; Cells, Cultured; Cholesterol Esters; Colchicine; Cyclopentanes; Cytoskeleton; Deoxyglucose; Enzyme Inhibitors; Estradiol; Female; Fluorescent Dyes; Granulosa Cells; Humans; Iodoacetates; Iodoacetic Acid; Kinetics; Lipoproteins, HDL; Microscopy, Confocal; Rats; Rats, Sprague-Dawley | 1996 |
Degradation and recycling of the substrate-binding subunit of type II iodothyronine 5'-deiodinase in astrocytes.
Topics: Animals; Animals, Newborn; Astrocytes; Binding Sites; Brain; Brefeldin A; Cells, Cultured; Cycloheximide; Cyclopentanes; Cytochalasin B; Enzyme Induction; Female; Iodide Peroxidase; Kinetics; Macromolecular Substances; Models, Biological; Molecular Weight; Organelles; Pregnancy; Protein Processing, Post-Translational; Protein Synthesis Inhibitors; Rats; Thyroxine; Triiodothyronine | 1996 |
Structural requirements for the ectodomain cleavage of human cell surface macrophage colony-stimulating factor.
Topics: 3T3 Cells; Allosteric Regulation; Amino Acid Sequence; Animals; Brefeldin A; Calcimycin; Cell Membrane; Chloroquine; Cyclopentanes; DNA, Complementary; Humans; Macrophage Colony-Stimulating Factor; Methionine; Mice; Models, Structural; Molecular Sequence Data; Mutagenesis, Site-Directed; Polymerase Chain Reaction; Protein Conformation; Protein Synthesis Inhibitors; Recombinant Proteins; Sequence Deletion; Sulfur Radioisotopes; Tetradecanoylphorbol Acetate; Transfection | 1996 |
Forskolin stimulates detoxification of brefeldin A.
Topics: Animals; Brefeldin A; Bucladesine; CHO Cells; Colforsin; Cricetinae; Cyclic AMP; Cyclopentanes; Cysteine; Glutathione; Golgi Apparatus; Guanosine Triphosphate; Inactivation, Metabolic; Kinetics; Mycotoxins | 1996 |
Insulin-induced GLUT4 recycling in rat adipose cells by a pathway insensitive to brefeldin A.
Topics: 3-O-Methylglucose; Adipose Tissue; Animals; Biological Transport; Brefeldin A; Cell Membrane; Cells, Cultured; Cyclopentanes; Electrophoresis, Polyacrylamide Gel; Fluorescent Antibody Technique; Glucose Transporter Type 4; Immunoblotting; Insulin; Kinetics; Male; Methylglucosides; Monosaccharide Transport Proteins; Muscle Proteins; Protein Synthesis Inhibitors; Rats; Rats, Sprague-Dawley | 1996 |
Roles of proteasomes, transporter for antigen presentation (TAP), and beta 2-microglobulin in the processing of bacterial or particulate antigens via an alternate class I MHC processing pathway.
Topics: Animals; Antigen Presentation; Antigens, Bacterial; ATP Binding Cassette Transporter, Subfamily B, Member 2; ATP-Binding Cassette Transporters; beta 2-Microglobulin; Brefeldin A; Cyclopentanes; Cysteine Endopeptidases; Histocompatibility Antigens Class I; In Vitro Techniques; Macrophages, Peritoneal; Mice; Mice, Inbred C57BL; Mice, Knockout; Models, Biological; Multienzyme Complexes; Ovalbumin; Protease Inhibitors; Proteasome Endopeptidase Complex; Subcellular Fractions | 1996 |
Regulation of chloride channel trafficking by cyclic AMP via protein kinase A-independent pathway in A6 renal epithelial cells.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Animals; Brefeldin A; Cell Line; Chloride Channels; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Cyclopentanes; Enzyme Inhibitors; Epithelium; Ion Channel Gating; Isoquinolines; Kidney; Kinetics; Patch-Clamp Techniques; Sulfonamides | 1996 |
The ubiquitin conjugation system is required for ligand-induced endocytosis and degradation of the growth hormone receptor.
Topics: Animals; Anti-Bacterial Agents; Brefeldin A; Cricetinae; Cricetulus; Cyclopentanes; DNA, Complementary; Down-Regulation; Electrophoresis, Polyacrylamide Gel; Endocytosis; Macrolides; Protein Synthesis Inhibitors; Receptors, Somatotropin; Signal Transduction; Transfection; Ubiquitins | 1996 |
Dissociation of the complex between the neuroendocrine chaperone 7B2 and prohormone convertase PC2 is not associated with proPC2 maturation.
Topics: Animals; Aspartic Acid Endopeptidases; Brefeldin A; Cyclopentanes; Electrophoresis, Polyacrylamide Gel; Enzyme Precursors; Mice; Mice, Inbred Strains; Molecular Chaperones; Monensin; Nerve Tissue Proteins; Neuroendocrine Secretory Protein 7B2; Pituitary Gland; Pituitary Hormones; Precipitin Tests; Pro-Opiomelanocortin; Proprotein Convertase 2; Proprotein Convertases; Protein Processing, Post-Translational; Recombinant Proteins; Subtilisins; Xenopus laevis | 1996 |
Oligomerization and maturation of Na,K-ATPase: functional interaction of the cytoplasmic NH2 terminus of the beta subunit with the alpha subunit.
Topics: Amino Acid Sequence; Animals; Base Sequence; Biological Transport; Brefeldin A; Cyclopentanes; Endoplasmic Reticulum; Molecular Sequence Data; Oocytes; Protein Conformation; Protein Synthesis Inhibitors; Proto-Oncogene Proteins c-myc; Recombinant Fusion Proteins; RNA, Complementary; Rubidium Radioisotopes; Sodium-Potassium-Exchanging ATPase; Trypsin; Xenopus | 1996 |
Brefeldin A distorts discoid and polarized morphological organizations of epithelial cells in culture.
Topics: Actins; Animals; Brefeldin A; Cell Line; Cell Polarity; Cell Size; Cyclopentanes; Dogs; Epithelial Cells; Epithelium; Hepatocyte Growth Factor; Kidney Tubules, Distal; Microscopy, Fluorescence; Tubulin | 1996 |
Release of a soluble form of growth hormone receptors (growth hormone-binding proteins) from human IM-9 cells by proteolytic cleavage.
Topics: Brefeldin A; Carrier Proteins; Cells, Cultured; Cycloheximide; Cyclopentanes; Humans; Immunoblotting; Lymphocytes; Peptide Hydrolases; Protease Inhibitors; Protein Synthesis Inhibitors; Solubility | 1995 |
Brefeldin A enables synthesis of active lipoprotein lipase in cld/cld and castanospermine-treated mouse brown adipocytes via translocation of Golgi components to endoplasmic reticulum.
Topics: Adipocytes; Adipose Tissue, Brown; Animals; Animals, Newborn; Biological Transport; Brefeldin A; Cell Compartmentation; Cyclopentanes; Endoplasmic Reticulum; Glycosylation; Golgi Apparatus; Indolizines; Lipase; Lipoprotein Lipase; Mice; Mice, Mutant Strains; Organelles; Protein Processing, Post-Translational | 1996 |
Opposite sorting of tissue factor in human umbilical vein endothelial cells and Madin-Darby canine kidney epithelial cells.
Topics: Amino Acid Sequence; Animals; Anti-Bacterial Agents; Antigens, Surface; Base Sequence; Brefeldin A; Cell Compartmentation; Cell Membrane; Cell Polarity; Chlorocebus aethiops; Cyclopentanes; Cytoplasm; DNA Primers; Dogs; Endothelium, Vascular; Humans; Interleukin-1; Macrolides; Molecular Sequence Data; Sequence Alignment; Sequence Deletion; Sequence Homology, Amino Acid; Structure-Activity Relationship; Thromboplastin; Transfection; Umbilical Veins | 1996 |
Intracellular distribution of Arf proteins in mammalian cells. Arf6 is uniquely localized to the plasma membrane.
Topics: ADP-Ribosylation Factors; Amino Acid Sequence; Animals; Antibodies; Blotting, Northern; Blotting, Western; Brefeldin A; Carrier Proteins; Cell Membrane; Clathrin; Coatomer Protein; Cricetinae; Cricetulus; Cyclopentanes; Electrophoresis, Polyacrylamide Gel; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Membrane Proteins; Molecular Sequence Data; Sequence Homology, Amino Acid; Substrate Specificity | 1996 |
Brefeldin A inhibits the antiviral action of interferon against encephalomyocarditis virus.
Topics: 2',5'-Oligoadenylate Synthetase; Animals; Antiviral Agents; Brefeldin A; Cyclopentanes; Drug Antagonism; eIF-2 Kinase; Encephalomyocarditis virus; Gene Expression; Interferon-beta; L Cells; Mice; Poly I-C; Protein Serine-Threonine Kinases; RNA, Messenger | 1996 |
Identification and characterization of a 230-kDa Golgi-associated protein recognized by autoantibodies from a patient with HBV hepatitis.
Topics: Autoantibodies; Autoantigens; Blotting, Western; Brefeldin A; Cell Compartmentation; Cyclopentanes; Fluorescent Antibody Technique, Indirect; Golgi Apparatus; Hepatitis B; Humans; Membrane Proteins; Molecular Weight; Nocodazole; Tumor Cells, Cultured | 1996 |
Introduction of exogenous antigens into the MHC class I processing and presentation pathway by Drosophila antennapedia homeodomain primes cytotoxic T cells in vivo.
Topics: Amino Acid Sequence; Animals; Antennapedia Homeodomain Protein; Antigen Presentation; Brefeldin A; Clone Cells; Cyclopentanes; Cytotoxicity, Immunologic; Drosophila; Drosophila Proteins; Histocompatibility Antigens Class I; Homeodomain Proteins; Lymphocyte Activation; Mice; Molecular Sequence Data; Nuclear Proteins; Recombinant Fusion Proteins; Sodium Dodecyl Sulfate; T-Lymphocytes, Cytotoxic; Transcription Factors | 1996 |
In search of the cellular site of growth hormone (GH)-binding protein cleavage from the rabbit GH receptor.
Topics: Animals; Brefeldin A; Carrier Proteins; CHO Cells; Cricetinae; Cyclopentanes; Cytoskeleton; Energy Metabolism; Lysosomes; Rabbits; Receptors, Somatotropin; Trypsin | 1996 |
Processing of human cytomegalovirus glycoprotein B in recombinant adenovirus-infected cells.
Topics: Adenoviruses, Human; Brefeldin A; Cyclopentanes; Cytomegalovirus; Endopeptidases; Enzyme Inhibitors; Genetic Vectors; Glycosylation; Humans; Protein Precursors; Protein Processing, Post-Translational; Protein Synthesis Inhibitors; Recombinant Fusion Proteins; Swainsonine; Tumor Cells, Cultured; Viral Envelope Proteins | 1996 |
Methylamine decreases trafficking and packaging of newly synthesized phosphatidylcholine in lamellar bodies in alveolar type II cells.
Topics: Acridine Orange; Adenosine Triphosphate; Ammonium Chloride; Animals; Brefeldin A; Cells, Cultured; Centrifugation, Density Gradient; Choline; Cyclopentanes; Hydrogen-Ion Concentration; Ionophores; Methylamines; Microscopy, Fluorescence; Monensin; Organelles; Phosphatidylcholines; Phospholipids; Pulmonary Alveoli; Pulmonary Surfactants; Quinacrine; Rats | 1996 |
Organization of the endoplasmic reticulum-Golgi system is related to the state of enterocytic differentiation of human HT-29 cells.
Topics: Antineoplastic Agents; Brefeldin A; Cell Differentiation; Cell Division; Cell Membrane; Colonic Neoplasms; Cyclopentanes; Cytochalasin D; Cytoskeleton; Endoplasmic Reticulum; Golgi Apparatus; Humans; Microscopy, Electron; Microscopy, Immunoelectron; Nocodazole; Protein Synthesis Inhibitors; Tumor Cells, Cultured | 1996 |
Brefeldin A inhibition of apical Na+ channels in epithelia.
Topics: Aldosterone; Biological Transport; Brefeldin A; Cell Line; Cell Membrane; Cyclopentanes; Epithelial Cells; Epithelium; Models, Biological; Nystatin; Sodium; Sodium Channel Blockers | 1996 |
Interaction of natural killer cells with MHC class II: reversal of HLA-DR1-mediated protection of K562 transfectant from natural killer cell-mediated cytolysis by brefeldin-A.
Topics: Brefeldin A; Cyclopentanes; Cytotoxicity Tests, Immunologic; Histocompatibility Antigens Class II; HLA-DR Antigens; Humans; Killer Cells, Lymphokine-Activated; Killer Cells, Natural; Protein Synthesis Inhibitors; Tumor Cells, Cultured | 1996 |
Activation of the sphingomyelin cycle by brefeldin A: effects of brefeldin A on differentiation and implications for a role for ceramide in regulation of protein trafficking.
Topics: Anti-Bacterial Agents; Antifungal Agents; Biological Transport; Brefeldin A; Cell Differentiation; Cell Division; Ceramides; Cyclopentanes; Enzyme Activation; Enzyme Inhibitors; Humans; Hydrolysis; Macrolides; Okadaic Acid; Phosphoprotein Phosphatases; Sphingomyelins; Tumor Cells, Cultured | 1996 |
Discrimination between constitutive secretion and basal secretion from the regulated secretory pathway in GH3 cells.
Topics: Amides; Animals; Anti-Bacterial Agents; Biological Transport; Brefeldin A; Cells, Cultured; Cyclopentanes; Cytoplasmic Granules; Endoplasmic Reticulum, Rough; Enzyme Inhibitors; Gastrins; Golgi Apparatus; Humans; Macrolides; Pituitary Gland; Potassium Chloride; Protein Precursors; Proton-Translocating ATPases; Rats; Recombinant Proteins; Secretory Rate; Temperature; Transfection; Tumor Cells, Cultured; Vacuolar Proton-Translocating ATPases | 1996 |
The role of targeted secretion in the establishment of cell polarity and the orientation of the division plane in Fucus zygotes.
Topics: Actins; Boron Compounds; Brefeldin A; Calcium Channels; Calcium Channels, L-Type; Cell Differentiation; Cell Division; Cell Polarity; Cell Size; Cell Wall; Cyclopentanes; Dihydropyridines; Ethylenediamines; Fluorescent Dyes; Golgi Apparatus; Isoquinolines; Phaeophyceae; Polysaccharides; Tolonium Chloride | 1996 |
Rab4 and cellubrevin define different early endosome populations on the pathway of transferrin receptor recycling.
Topics: Animals; Brefeldin A; Cell Compartmentation; Cell Line; Cell Membrane; Cricetinae; Cricetulus; Cyclopentanes; Endosomes; Fluorescein-5-isothiocyanate; Fluorescent Antibody Technique, Direct; GTP-Binding Proteins; Humans; Kinetics; Membrane Proteins; Microscopy, Confocal; Nocodazole; rab4 GTP-Binding Proteins; Receptors, Transferrin; Vesicle-Associated Membrane Protein 3 | 1996 |
Inhibition of vesicle-mediated protein transport by nordihydroguaiaretic acid.
Topics: Animals; Biological Transport; Brefeldin A; Carrier Proteins; Cell Line; Cell Membrane; Cricetinae; Cyclopentanes; Endoplasmic Reticulum; Endoplasmic Reticulum Chaperone BiP; Glycoproteins; Golgi Apparatus; Heat-Shock Proteins; Mannosidases; Masoprocol; Membrane Glycoproteins; Microtubules; Molecular Chaperones; Vesicular stomatitis Indiana virus; Viral Envelope Proteins | 1996 |
Expression and release of the a and b subunits for human coagulation factor XIII in baby hamster kidney (BHK) cells.
Topics: 2,4-Dinitrophenol; Animals; Blotting, Western; Brefeldin A; Carbonyl Cyanide m-Chlorophenyl Hydrazone; Cell Line; Chromatography, Gel; Cricetinae; Cyclopentanes; Enzyme Induction; Enzyme-Linked Immunosorbent Assay; Factor XIII; Hot Temperature; Humans; Molecular Weight; Monensin; Protein Synthesis Inhibitors; Recombinant Proteins; Thrombin; Transfection | 1996 |
Involvement of the chaperone protein calnexin and the acetylcholine receptor beta-subunit in the assembly and cell surface expression of the receptor.
Topics: Animals; Blotting, Western; Brefeldin A; Calcium-Binding Proteins; Calnexin; Cell Line; Cell Membrane; Cyclopentanes; Mice; Molecular Chaperones; Protein Conformation; Receptors, Cholinergic; Transfection | 1996 |
Co-localization of the TSC2 product tuberin with its target Rap1 in the Golgi apparatus.
Topics: Animals; Antibodies; Brefeldin A; Cells, Cultured; Chromatography, Affinity; Cyclopentanes; Fluorescent Antibody Technique, Indirect; Golgi Apparatus; GTP-Binding Proteins; Humans; Microscopy, Confocal; Protein Synthesis Inhibitors; Rabbits; rap GTP-Binding Proteins; Rats; Recombinant Fusion Proteins; Repressor Proteins; Tissue Distribution; Tuberous Sclerosis Complex 2 Protein; Tumor Suppressor Proteins | 1996 |
Protein synthesis within dendrites: glycosylation of newly synthesized proteins in dendrites of hippocampal neurons in culture.
Topics: Animals; Brefeldin A; Carbohydrate Metabolism; Cells, Cultured; Cyclopentanes; Dendrites; Endoplasmic Reticulum, Rough; Glycosylation; Golgi Apparatus; Hippocampus; Immunohistochemistry; Nerve Tissue Proteins; Neurons; Protein Synthesis Inhibitors; Rats; Temperature; Tissue Distribution | 1996 |
In vitro effects of anti-HIV immunotoxins directed against multiple epitopes on HIV type 1 envelope glycoprotein 160.
Topics: Anti-Bacterial Agents; Antifungal Agents; Brefeldin A; Cell Line; Cortisone; Cyclopentanes; Cytochalasin D; Enzyme-Linked Immunosorbent Assay; Epitopes; HIV Envelope Protein gp160; HIV Envelope Protein gp41; HIV-1; Humans; Immunotoxins; Macrolides; Microscopy, Electron, Scanning; Nocodazole; Phytohemagglutinins | 1996 |
Brefeldin A is a potent inducer of apoptosis in human cancer cells independently of p53.
Topics: Alkaloids; Antineoplastic Agents, Phytogenic; Apoptosis; Brefeldin A; Camptothecin; Cell-Free System; Cyclin B; Cyclin B1; Cyclins; Cycloheximide; Cyclopentanes; DNA Fragmentation; DNA, Neoplasm; Dose-Response Relationship, Drug; Enzyme Inhibitors; Etoposide; HL-60 Cells; HT29 Cells; Humans; Mutation; Protein Synthesis Inhibitors; Staurosporine; Time Factors; Tumor Suppressor Protein p53 | 1996 |
The mammalian ARF-like protein 1 (Arl1) is associated with the Golgi complex.
Topics: ADP-Ribosylation Factors; Aluminum Compounds; Amino Acid Sequence; Animals; Antibodies; Base Sequence; Blotting, Northern; Brefeldin A; Cell Line; Cell Nucleus; CHO Cells; Cloning, Molecular; Cricetinae; Cyclopentanes; DNA, Complementary; Fluorides; Golgi Apparatus; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); L Cells; LLC-PK1 Cells; Mammals; Mice; Molecular Sequence Data; Nocodazole; Rabbits; Rats; Recombinant Fusion Proteins; Sequence Homology, Amino Acid; Swine | 1996 |
Brefeldin A inhibits experimentally induced AA amyloidosis.
Topics: Amyloidosis; Animals; Brefeldin A; Chromatography, Affinity; Chromatography, Ion Exchange; Cyclopentanes; Electrophoresis, Polyacrylamide Gel; Female; Freund's Adjuvant; Immunohistochemistry; Mice; Mice, Inbred CBA; Microscopy, Electron; Protein Synthesis Inhibitors; Serum Amyloid A Protein; Spleen | 1996 |
Recovery of protein secretion after brefeldin A treatment of rat lacrimal glands: effect of cAMP.
Topics: Animals; Brefeldin A; Cyclic AMP; Cyclopentanes; Exocytosis; Golgi Apparatus; Lacrimal Apparatus; Male; Protein Biosynthesis; Protein Synthesis Inhibitors; Rats; Rats, Sprague-Dawley | 1996 |
Endoplasmic reticulum-to-cytosol transport of free polymannose oligosaccharides in permeabilized HepG2 cells.
Topics: Adenosine Triphosphate; Anti-Bacterial Agents; Brefeldin A; Cell Membrane Permeability; Chromatography, Thin Layer; Cyclopentanes; Endoplasmic Reticulum; Glycopeptides; Glycoside Hydrolases; Hepatoblastoma; Humans; Hydrolysis; Macrolides; Mannose; Oligosaccharides; Saponins; Tumor Cells, Cultured | 1995 |
Effect of deoxymannojirimycin and Brefeldin A on Yersinia pseudotuberculosis invasin--eukaryotic cell interaction.
Topics: 1-Deoxynojirimycin; Adhesins, Bacterial; alpha-Mannosidase; Amino Acid Sequence; Animals; Bacterial Proteins; Brefeldin A; Cell Adhesion; Cell Line; Cell Membrane; CHO Cells; Cricetinae; Cyclopentanes; Enzyme Inhibitors; Epithelial Cells; Escherichia coli; Fibronectins; Golgi Apparatus; Humans; Integrin alpha3beta1; Integrin alpha6beta1; Integrins; Mannosidases; Molecular Sequence Data; Oligosaccharides; Yersinia pseudotuberculosis | 1995 |
The basolateral sorting signal of the polymeric immunoglobulin receptor contains two functional domains.
Topics: Alanine; Animals; Brefeldin A; Cells, Cultured; Cyclopentanes; Cytoplasm; Dogs; Kidney; Point Mutation; Protein Conformation; Protein Synthesis Inhibitors; Receptors, Polymeric Immunoglobulin | 1996 |
p619, a giant protein related to the chromosome condensation regulator RCC1, stimulates guanine nucleotide exchange on ARF1 and Rab proteins.
Topics: ADP-Ribosylation Factor 1; ADP-Ribosylation Factors; Amino Acid Sequence; Animals; Brefeldin A; Cell Cycle; Cell Cycle Proteins; Cloning, Molecular; Cyclopentanes; DNA-Binding Proteins; Genes; Golgi Apparatus; GTP-Binding Proteins; Guanine Nucleotide Dissociation Inhibitors; Guanine Nucleotide Exchange Factors; Guanosine Triphosphate; Humans; Mice; Molecular Sequence Data; Mycotoxins; Nuclear Proteins; Rats; Repetitive Sequences, Nucleic Acid; RNA, Messenger; Sequence Alignment; Sequence Homology, Amino Acid; Subcellular Fractions; Ubiquitin-Protein Ligases | 1996 |
Brefeldin A and mannose 6-phosphate regulation of acrosomic related vesicular trafficking.
Topics: Acrosin; Acrosome; Animals; Boron Compounds; Brefeldin A; Cell Membrane; Coatomer Protein; Coculture Techniques; Cyclopentanes; Fluorescent Dyes; Golgi Apparatus; Isomerases; Male; Mannosephosphates; Mice; Mice, Inbred Strains; Microscopy, Fluorescence; Microtubule-Associated Proteins; Protein Disulfide-Isomerases; Protein Synthesis Inhibitors; Pyridinium Compounds; Quaternary Ammonium Compounds; Sertoli Cells; Spermatids | 1996 |
Avian reovirus-induced syncytium formation is independent of infectious progeny virus production and enhances the rate, but is not essential, for virus-induced cytopathology and virus egress.
Topics: Animals; Antiviral Agents; Biological Transport; Brefeldin A; Cell Line; Cyclopentanes; Cytopathogenic Effect, Viral; Deoxyglucose; Giant Cells; Mice; Orthoreovirus; Protein Synthesis Inhibitors; Tumor Cells, Cultured; Tunicamycin; Viral Proteins; Virus Replication | 1996 |
Brefeldin A inhibits antigen- or calcium ionophore-mediated but not PMA-induced phospholipase D activation in rat basophilic leukemia (RBL-2H3) cells.
Topics: Animals; Antigens; Brefeldin A; Calcimycin; Cyclopentanes; Enzyme Activation; Leukemia, Mast-Cell; Phospholipase D; Rats; Serotonin; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1996 |
Brefeldin A inhibits the constitutive-like secretion of a sulfated protein in pancreatic acinar cells.
Topics: Amino Acid Sequence; Animals; Biological Transport; Brefeldin A; Cell Polarity; Cyclopentanes; Cytoplasmic Granules; Fluorescent Antibody Technique; Golgi Apparatus; Mice; Molecular Sequence Data; Pancreas; Protein Processing, Post-Translational; Protein Synthesis Inhibitors; Proteins; Sequence Analysis; Subcellular Fractions | 1996 |
Constitutive and inducible mechanisms for synthesis and release of cytokines in immune cell lines.
Topics: Animals; Brefeldin A; Cyclopentanes; Dexamethasone; Enzyme Inhibitors; Gene Expression Regulation; Golgi Apparatus; Humans; Indoles; Leukemia, Basophilic, Acute; Lymphocyte Activation; Lymphoma, Large B-Cell, Diffuse; Macrophage Activation; Macrophages; Maleimides; Mast Cells; Protein Kinase C; Rats; Signal Transduction; T-Lymphocytes; Transforming Growth Factor beta; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha | 1996 |
Preferential processing of the S1 subunit of pertussis toxin that is bound to eukaryotic cells.
Topics: Animals; Biological Transport; Brefeldin A; Cell Compartmentation; Chloroquine; CHO Cells; Cricetinae; Cyclopentanes; Dogs; Endosomes; Eukaryotic Cells; Iodine Radioisotopes; Isotope Labeling; Models, Biological; Nocodazole; Pertussis Toxin; Pronase; Protein Conformation; Receptors, Cell Surface; Swine; Virulence Factors, Bordetella | 1996 |
Mammalian Cdc42 is a brefeldin A-sensitive component of the Golgi apparatus.
Topics: Animals; Brefeldin A; cdc42 GTP-Binding Protein; Cell Cycle Proteins; Cyclopentanes; Golgi Apparatus; GTP-Binding Proteins; Microscopy, Fluorescence; Rabbits | 1996 |
The importance of the Golgi complex for epithelial ion transport in Drosophila Malpighian tubules, studied by electron microscopy, cytochemistry and X-ray microanalysis.
Topics: Animals; Biological Transport, Active; Brefeldin A; Cyclopentanes; Drosophila; Electron Probe Microanalysis; Epithelium; Freeze Drying; Glycosaminoglycans; Golgi Apparatus; Histocytochemistry; Ion Transport; Malpighian Tubules; Microscopy, Electron; Potassium; Protein Synthesis Inhibitors | 1996 |
Direct vesicular transport of MHC class II molecules from lysosomal structures to the cell surface.
Topics: Biological Transport; Brefeldin A; Cell Membrane; Cyclopentanes; Endosomes; Green Fluorescent Proteins; HLA-DR1 Antigen; Humans; Intracellular Membranes; Luminescent Proteins; Lysosomes; Melanoma; Membrane Fusion; Microscopy, Confocal; Protein Synthesis Inhibitors; Recombinant Fusion Proteins; Tumor Cells, Cultured | 1996 |
Membrane tethering enables an extracellular domain of the acetylcholine receptor alpha subunit to form a heterodimeric ligand-binding site.
Topics: Amino Acid Sequence; Animals; Binding Sites; Brefeldin A; Bungarotoxins; COS Cells; Cyclopentanes; Dimerization; Endoplasmic Reticulum; Glycosylphosphatidylinositols; Intracellular Membranes; Ligands; Mice; Molecular Sequence Data; Peptide Fragments; Protein Conformation; Protein Folding; Protein Synthesis Inhibitors; Receptors, Nicotinic | 1996 |
Degradation of distinct assembly forms of immunoglobulin M occurs in multiple sites in permeabilized B cells.
Topics: Animals; B-Lymphocytes; Bacterial Proteins; Brefeldin A; Cell Line; Cell Membrane Permeability; Cyclopentanes; Cysteine; Digitonin; Dithiothreitol; Endoplasmic Reticulum; Golgi Apparatus; Hybridomas; Immunoglobulin Light Chains; Immunoglobulin M; Kinetics; Methionine; Mice; Protein Synthesis Inhibitors; Streptolysins; Sulfhydryl Compounds; Sulfones | 1996 |
Metabolites of the beta-amyloid precursor protein generated by beta-secretase localise to the trans-Golgi network and late endosome in 293 cells.
Topics: Amino Acid Sequence; Amyloid beta-Protein Precursor; Amyloid Precursor Protein Secretases; Aspartic Acid Endopeptidases; Brefeldin A; Cell Line; Chromatography, Affinity; Cyclopentanes; Endopeptidases; Endosomes; Enzyme-Linked Immunosorbent Assay; Fluorescent Antibody Technique, Direct; Golgi Apparatus; Humans; Immunohistochemistry; Kidney; Microscopy, Confocal; Molecular Sequence Data; Protein Synthesis Inhibitors; Transfection | 1996 |
Isolation of a brefeldin A-inhibited guanine nucleotide-exchange protein for ADP ribosylation factor (ARF) 1 and ARF3 that contains a Sec7-like domain.
Topics: ADP-Ribosylation Factors; Amino Acid Sequence; Animals; Brefeldin A; Cattle; Cerebral Cortex; Chromatography; Chromatography, Gel; Chromatography, Ion Exchange; Cyclopentanes; Durapatite; Fungal Proteins; GTP-Binding Proteins; Guanine Nucleotide Exchange Factors; Kinetics; Molecular Sequence Data; Protein Synthesis Inhibitors; Rats; Saccharomyces cerevisiae; Sequence Homology, Amino Acid | 1996 |
Cyclic AMP induces apolipoprotein E binding activity and promotes cholesterol efflux from a macrophage cell line to apolipoprotein acceptors.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Animals; Apolipoproteins E; Brefeldin A; Cell Compartmentation; Cell Line; Cholesterol; Cyclic AMP; Cyclopentanes; Humans; Ionophores; Low Density Lipoprotein Receptor-Related Protein-1; Macrophages; Mice; Monensin; Receptors, Lipoprotein; Transfection | 1996 |
In vivo assembly of coatomer, the COP-I coat precursor.
Topics: Animals; Biological Transport; Brefeldin A; Chlorocebus aethiops; Coatomer Protein; Cyclopentanes; Immunologic Techniques; Intracellular Membranes; Macromolecular Substances; Membrane Proteins; Microtubule-Associated Proteins; Protein Binding; Vero Cells | 1996 |
Delayed activation of the mannose receptor following synthesis. Requirement for exit from the endoplasmic reticulum.
Topics: Aluminum Compounds; Binding Sites; Biological Transport; Brefeldin A; Cell Compartmentation; Coatomer Protein; Cyclopentanes; Endoplasmic Reticulum; Fluorides; Glycosylation; Golgi Apparatus; Hexosaminidases; Humans; Lectins, C-Type; Ligands; Macrophages; Mannose Receptor; Mannose-Binding Lectins; Mannosides; Microtubule-Associated Proteins; Protein Binding; Protein Processing, Post-Translational; Receptors, Cell Surface; Structure-Activity Relationship; Time Factors | 1996 |
Functional analysis of the glycosylation of murine acid sphingomyelinase.
Topics: Animals; Brefeldin A; Carbohydrate Conformation; Cell Line; Cyclopentanes; Glycosylation; Humans; Lysosomes; Mannosephosphates; Mice; Oligosaccharides; Protein Conformation; Protein Synthesis Inhibitors; Sphingomyelin Phosphodiesterase; Tunicamycin | 1996 |
Endocytosis and Ca2+ are required for endotoxin-stimulated TNF-alpha release by rat Kupffer cells.
Topics: Animals; Anti-Bacterial Agents; Brefeldin A; Calcium; Cells, Cultured; Cyclopentanes; Cytochalasin B; Endocytosis; Endotoxins; Escherichia coli; Kinetics; Kupffer Cells; Lipopolysaccharides; Macrolides; Male; Monensin; Nisoldipine; Rats; Rats, Sprague-Dawley; RNA, Messenger; Transcription, Genetic; Tumor Necrosis Factor-alpha | 1996 |
Protein movement across cultured guinea pig trachea: specificity and effect of transcytosis inhibitors.
Topics: Animals; Brefeldin A; Cell Membrane; Cells, Cultured; Cyclopentanes; Dextrans; Endocytosis; Epithelial Cells; Epithelium; Female; Guinea Pigs; Male; Membrane Potentials; Monensin; Nocodazole; Ovalbumin; Proteins; Serum Albumin, Bovine; Trachea | 1996 |
Ligand-regulated transport of the Menkes copper P-type ATPase efflux pump from the Golgi apparatus to the plasma membrane: a novel mechanism of regulated trafficking.
Topics: Adenosine Triphosphatases; Adenosine Triphosphate; Animals; Anti-Bacterial Agents; Autoantigens; Blotting, Northern; Blotting, Western; Brefeldin A; Carrier Proteins; Cation Transport Proteins; Cell Membrane; CHO Cells; Copper; Copper-Transporting ATPases; Cricetinae; Cycloheximide; Cyclopentanes; Fluorescent Antibody Technique; Golgi Apparatus; Humans; Macrolides; Membrane Proteins; Menkes Kinky Hair Syndrome; Metals, Heavy; Microscopy, Electron; Nocodazole; Recombinant Fusion Proteins | 1996 |
A tyrosine-based motif and a casein kinase II phosphorylation site regulate the intracellular trafficking of the varicella-zoster virus glycoprotein I, a protein localized in the trans-Golgi network.
Topics: Adaptor Protein Complex gamma Subunits; Amino Acid Sequence; Binding Sites; Brefeldin A; Casein Kinase II; Cyclopentanes; Endosomes; Furin; Gene Expression Regulation, Viral; Glycoproteins; Golgi Apparatus; HeLa Cells; Humans; Membrane Glycoproteins; Membrane Proteins; Microscopy, Fluorescence; Molecular Sequence Data; Phosphorylation; Protein Serine-Threonine Kinases; Protein Sorting Signals; Receptor, IGF Type 2; Recombinant Fusion Proteins; Subtilisins; Viral Envelope Proteins | 1996 |
The isoforms of proprotein convertase PC5 are sorted to different subcellular compartments.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Amino Acid Sequence; Animals; Brefeldin A; Cell Compartmentation; Cyclopentanes; Cytoplasmic Granules; Enzyme Precursors; Fluorescent Antibody Technique, Indirect; Glucagon; Golgi Apparatus; Isoenzymes; Mice; Microscopy, Immunoelectron; Molecular Sequence Data; Pancreas; Proprotein Convertase 5; Protein Processing, Post-Translational; Rats; Rats, Sprague-Dawley; Serine Endopeptidases; Solubility; Transfection; Tumor Cells, Cultured | 1996 |
Thyroidal extracellular glutathione peroxidase: a potential regulator of thyroid-hormone synthesis.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Blotting, Western; Brefeldin A; Calcimycin; Cells, Cultured; Culture Media; Cyclopentanes; Electrophoresis, Polyacrylamide Gel; Extracellular Space; Glutathione Peroxidase; Humans; Proteins; Selenoproteins; Sodium Selenite; Tetradecanoylphorbol Acetate; Thyroid Gland; Thyroid Hormones; Thyrotropin | 1995 |
Monensin and verapamil do not alter intracellular localisation of daunorubicin in multidrug resistant human KB cells.
Topics: Antibiotics, Antineoplastic; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Brefeldin A; Calcium Channel Blockers; Cyclopentanes; Daunorubicin; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Exocytosis; Golgi Apparatus; Humans; Ionophores; KB Cells; Monensin; Neoplasm Proteins; Subcellular Fractions; Verapamil | 1996 |
Vascular endothelial cell monolayer formed on membrane filter potentiates the defense against tumor cell invasion by treatment with brefeldin A.
Topics: Brefeldin A; Cell Adhesion; Cells, Cultured; Collagenases; Cyclopentanes; Endothelium, Vascular; Extracellular Matrix; Humans; Neoplasm Invasiveness; Plasminogen Activator Inhibitor 1; Tissue Plasminogen Activator; Tumor Cells, Cultured; Umbilical Veins; Urokinase-Type Plasminogen Activator | 1996 |
Effect of brefeldin A on influenza A virus-induced apoptosis in vitro.
Topics: Acetylcysteine; Animals; Antiviral Agents; Apoptosis; Brefeldin A; Cell Line; Cyclopentanes; DNA; DNA Fragmentation; Dogs; Influenza A virus; Kidney | 1996 |
Transcellular delivery of an insulin-transferrin conjugate in enterocyte-like Caco-2 cells.
Topics: Biological Transport; Brefeldin A; Caco-2 Cells; Cyclopentanes; Humans; Insulin; Insulin Antibodies; Receptors, Transferrin; Transferrin | 1996 |
Immune CD8+ T lymphocytes lyse Listeria monocytogenes-infected hepatocytes by a classical MHC class I-restricted mechanism.
Topics: Animals; Anti-Bacterial Agents; Antibodies, Monoclonal; Brefeldin A; CD8 Antigens; CD8-Positive T-Lymphocytes; Cells, Cultured; Cyclopentanes; Cytotoxicity, Immunologic; Female; H-2 Antigens; Listeria monocytogenes; Liver; Macrolides; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; T-Lymphocytes, Cytotoxic | 1997 |
Free ricin A chain reaches an early compartment of the secretory pathway before it enters the cytosol.
Topics: Amino Acid Sequence; Biological Transport, Active; Brefeldin A; Cell Compartmentation; Cyclopentanes; Cytosol; GTP Phosphohydrolases; HeLa Cells; Humans; Mutation; Protein Synthesis Inhibitors; Ricin | 1996 |
Targeting of Moloney murine leukemia virus gag precursor to the site of virus budding.
Topics: Antiviral Agents; Biological Transport; Brefeldin A; Cell Membrane; Cold Temperature; Cyclopentanes; Endopeptidases; Gene Expression Regulation, Viral; Gene Products, gag; Genome, Viral; Ionophores; Kinetics; Microscopy, Electron; Moloney murine leukemia virus; Monensin; Protein Precursors; Recombinant Proteins; Semliki forest virus; Subcellular Fractions; Virus Replication | 1996 |
Studies on the site and mechanism of attachment of phosphorylcholine to a filarial nematode secreted glycoprotein.
Topics: Animals; Binding Sites; Brefeldin A; Cyclopentanes; Dipetalonema; Gerbillinae; Glycoproteins; Oligosaccharides; Phosphorylcholine; Polysaccharides; Protein Binding | 1997 |
Degradation of the Met tyrosine kinase receptor by the ubiquitin-proteasome pathway.
Topics: Acetylcysteine; Animals; Brefeldin A; Cell Line; Cell Membrane; Cyclopentanes; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Hepatocyte Growth Factor; Humans; Ligands; Molecular Weight; Multienzyme Complexes; Nerve Growth Factors; Peptide Fragments; Phosphorylation; Proteasome Endopeptidase Complex; Protein Synthesis Inhibitors; Proto-Oncogene Proteins c-met; Receptor Protein-Tyrosine Kinases; Recombinant Fusion Proteins; Tetradecanoylphorbol Acetate; Transfection; Ubiquitins | 1997 |
GLUT4 in cultured skeletal myotubes is segregated from the transferrin receptor and stored in vesicles associated with TGN.
Topics: Animals; Brefeldin A; Cell Compartmentation; Cell Line; Cyclopentanes; Fluorescent Antibody Technique, Indirect; Glucose Transporter Type 4; Golgi Apparatus; Mice; Microtubules; Monosaccharide Transport Proteins; Muscle Proteins; Muscle, Skeletal; Receptors, Transferrin | 1996 |
Potassium channel alpha and beta subunits assemble in the endoplasmic reticulum.
Topics: Animals; Brefeldin A; Cell Line; Centrifugation, Density Gradient; Cold Temperature; Cyclopentanes; Disulfides; Endoplasmic Reticulum; Glycosylation; Golgi Apparatus; Humans; Kidney; Macromolecular Substances; Mammals; Oligosaccharides; Potassium Channels; Protein Synthesis Inhibitors; Recombinant Proteins; Shaker Superfamily of Potassium Channels; Transfection | 1997 |
Transport of sphingomyelin to the cell surface is inhibited by brefeldin A and in mitosis, where C6-NBD-sphingomyelin is translocated across the plasma membrane by a multidrug transporter activity.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Brefeldin A; Cell Compartmentation; Cell Membrane; Ceramides; CHO Cells; Cricetinae; Cyclopentanes; Glucosylceramides; Glucosyltransferases; Golgi Apparatus; HeLa Cells; Humans; Mitosis; Oxadiazoles; Sphingomyelins; Subcellular Fractions; Transferases (Other Substituted Phosphate Groups) | 1997 |
p230 is associated with vesicles budding from the trans-Golgi network.
Topics: Aluminum Compounds; Animals; Autoantibodies; Autoantigens; Brefeldin A; Cell Line; Cyclopentanes; Dogs; Fluorides; Golgi Apparatus; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); HeLa Cells; Humans; Membrane Proteins; Microscopy, Electron | 1996 |
Mouse mastocytoma cells synthesize undersulfated heparin and chondroitin sulfate in the presence of brefeldin A.
Topics: Animals; Antifungal Agents; Brefeldin A; Chondroitin Sulfates; Chromatography, High Pressure Liquid; Chromatography, Ion Exchange; Cyclopentanes; Heparin; Mast-Cell Sarcoma; Mice; Sarcoma, Experimental; Sulfates; Tumor Cells, Cultured | 1997 |
Proteolytic processing of sulfated secretogranin II in the trans-Golgi network of GH3B6 prolactin cells.
Topics: Animals; Brefeldin A; Chloroquine; Chromogranins; Cyclopentanes; Golgi Apparatus; Hydrogen-Ion Concentration; Neuropeptides; Neurosecretory Systems; Prolactin; Proteins; Sulfates; Thyrotropin-Releasing Hormone | 1997 |
Targeting of an intestinal apical endosomal protein to endosomes in nonpolarized cells.
Topics: Animals; Animals, Newborn; Brefeldin A; Cell Compartmentation; Cell Line; Cell Nucleus; Cell Polarity; Clathrin; Cyclopentanes; Endocytosis; Endosomes; Fibroblasts; Glycoproteins; Ileum; Intestinal Mucosa; Ovalbumin; Rats; Receptor, IGF Type 2; Ricin; Transfection; Transferrin | 1997 |
Apolipoprotein-mediated cellular cholesterol and phospholipid efflux depend on a functional Golgi apparatus.
Topics: Apolipoproteins; Biological Transport; Brefeldin A; Cholesterol; Cyclopentanes; Fibroblasts; Golgi Apparatus; Humans; Monensin; Phospholipids; Protein Synthesis Inhibitors | 1996 |
Transport through the yeast endocytic pathway occurs through morphologically distinct compartments and requires an active secretory pathway and Sec18p/N-ethylmaleimide-sensitive fusion protein.
Topics: Adenosine Triphosphatases; Biological Transport; Brefeldin A; Carboxypeptidases; Cathepsin A; Cell Compartmentation; Cell Membrane; Cyclopentanes; Endocytosis; Endosomes; Ethylmaleimide; Fungal Proteins; Receptors, Mating Factor; Receptors, Peptide; Recombinant Fusion Proteins; Saccharomyces cerevisiae Proteins; Transcription Factors; Vacuoles; Vesicular Transport Proteins; Yeasts | 1997 |
Comparative activity of ADP-ribosylation factor family members in the early steps of coated vesicle formation on rat liver Golgi membranes.
Topics: ADP-Ribosylation Factor 1; ADP-Ribosylation Factors; Animals; Brefeldin A; Coated Vesicles; Cyclopentanes; Golgi Apparatus; GTP-Binding Proteins; Guanine Nucleotides; Intracellular Membranes; Liver; Myristic Acid; Myristic Acids; Protein Binding; Rats; Recombinant Proteins; Trypsin | 1997 |
Interactions between newly synthesized glycoproteins, calnexin and a network of resident chaperones in the endoplasmic reticulum.
Topics: Animals; Brefeldin A; Calcium-Binding Proteins; Calnexin; CHO Cells; Cricetinae; Cross-Linking Reagents; Cyclopentanes; Endoplasmic Reticulum; Hemagglutinin Glycoproteins, Influenza Virus; Molecular Chaperones; Rabbits; Substrate Specificity | 1997 |
Immunofluorescence assay for the quantitative and qualitative evaluation of intracellular interleukin-8 in microtiter plates.
Topics: Brefeldin A; Cells, Cultured; Colchicine; Cyclopentanes; Endothelium, Vascular; Enzyme Inhibitors; Fatty Acids, Monounsaturated; Fluorescent Antibody Technique; Fluvastatin; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Indoles; Interleukin-8; Protein Synthesis Inhibitors | 1997 |
Processing of thionin precursors in barley leaves by a vacuolar proteinase.
Topics: Antimicrobial Cationic Peptides; Biological Transport; Brefeldin A; Cyclopentanes; Endopeptidases; Hordeum; Molecular Weight; Monensin; Plant Proteins; Protein Precursors; Recombinant Proteins; Structure-Activity Relationship; Substrate Specificity; Vacuoles | 1997 |
Cross-reactive cytotoxic T-lymphocyte-mediated lysis of Chlamydia trachomatis- and Chlamydia psittaci-infected cells.
Topics: Animals; Brefeldin A; Chlamydia trachomatis; Chlamydophila psittaci; Concanavalin A; Cross Reactions; Cycloheximide; Cyclopentanes; Cytotoxicity, Immunologic; Mice; Mice, Inbred C3H; Rabbits; Spleen; T-Lymphocytes, Cytotoxic | 1997 |
7-Dehydrobrefeldin A, a naturally occurring brefeldin A derivative, inhibits secretion and causes a cis-to-trans breakdown of Golgi stacks in plant cells.
Topics: Brefeldin A; Cells, Cultured; Cyclopentanes; Eukaryotic Cells; Golgi Apparatus; Lactones; Mycotoxins; Plant Proteins; Trees | 1997 |
COPI-independent anterograde transport: cargo-selective ER to Golgi protein transport in yeast COPI mutants.
Topics: Alleles; beta-Fructofuranosidase; Biological Transport; Brefeldin A; Carboxypeptidases; Cathepsin A; Coated Vesicles; Cyclopentanes; Endoplasmic Reticulum; Glycoproteins; Glycoside Hydrolases; Glycosylation; Golgi Apparatus; Heat-Shock Proteins; Mutation; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Temperature | 1997 |
A mouse cytomegalovirus glycoprotein, gp34, forms a complex with folded class I MHC molecules in the ER which is not retained but is transported to the cell surface.
Topics: Amino Acid Sequence; Animals; Antibodies, Viral; Brefeldin A; Carrier Proteins; Cells, Cultured; Cloning, Molecular; Cyclopentanes; Endoplasmic Reticulum; Fibroblasts; Genes, Viral; Glycoproteins; Hexosaminidases; Histocompatibility Antigens Class I; Membrane Glycoproteins; Mice; Molecular Sequence Data; Molecular Weight; Muromegalovirus; Protein Binding; Protein Folding; Protein Synthesis Inhibitors; Sequence Deletion; Viral Proteins | 1997 |
Brefeldin A and monensin arrest cell surface expression of membrane glycoproteins and release of rubella virus.
Topics: Animals; Brefeldin A; Cell Membrane; Chlorocebus aethiops; COS Cells; Cyclopentanes; Endopeptidases; Humans; Mice; Monensin; Polysaccharides; Protein Precursors; Protein Processing, Post-Translational; Recombinant Fusion Proteins; Rubella virus; Subcellular Fractions; Vero Cells; Viral Envelope Proteins; Virus Assembly | 1995 |
Rapid degradation of CD4 in cells expressing human immunodeficiency virus type 1 Env and Vpu is blocked by proteasome inhibitors.
Topics: Acetylcysteine; Amino Acid Sequence; Brefeldin A; CD4 Antigens; Cyclopentanes; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Gene Products, env; HeLa Cells; HIV-1; Human Immunodeficiency Virus Proteins; Humans; Leupeptins; Molecular Sequence Data; Multienzyme Complexes; Proteasome Endopeptidase Complex; Signal Transduction; Viral Regulatory and Accessory Proteins | 1997 |
Cytohesin-1, a cytosolic guanine nucleotide-exchange protein for ADP-ribosylation factor.
Topics: ADP-Ribosylation Factor 1; ADP-Ribosylation Factors; Amino Acid Sequence; Brefeldin A; Cell Adhesion Molecules; Cell Line, Transformed; Cloning, Molecular; Cyclopentanes; Fungal Proteins; Genes, Fungal; GTP-Binding Proteins; Guanine Nucleotide Exchange Factors; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Diphosphate; Guanosine Triphosphate; Humans; Molecular Sequence Data; Polymerase Chain Reaction; Protein Binding; Saccharomyces cerevisiae; Sequence Alignment; Sequence Analysis | 1997 |
GTP-bound forms of rab6 induce the redistribution of Golgi proteins into the endoplasmic reticulum.
Topics: Amino Acid Sequence; Antigens, Differentiation, B-Lymphocyte; Biomarkers; Brefeldin A; Carrier Proteins; Cyclopentanes; Endoplasmic Reticulum; Fluorescent Antibody Technique; Gene Expression Regulation; Glycosylation; Golgi Apparatus; Guanosine Diphosphate; Guanosine Triphosphate; HeLa Cells; Histocompatibility Antigens Class II; Humans; Lectins; Microtubules; Molecular Sequence Data; N-Acetyllactosamine Synthase; Plant Lectins; rab GTP-Binding Proteins; ras Proteins; Transfection | 1997 |
Apical sorting of hepatitis B surface antigen (HBsAg) is independent of N-glycosylation and glycosylphosphatidylinositol-anchored protein segregation.
Topics: Animals; Brefeldin A; Cell Line; Cyclopentanes; Dogs; Fibronectins; Glycosylation; Glycosylphosphatidylinositols; Hepatitis B Surface Antigens; Hexosamines; Laminin; Membrane Glycoproteins; Mutagenesis, Site-Directed; Polysaccharides; Precipitin Tests; Rats; Transfection; Tunicamycin | 1997 |
Differential fate of glycoproteins carrying a monoglucosylated form of truncated N-glycan in a new CHO line, MadIA214214, selected for a thermosensitive secretory defect.
Topics: Alkaline Phosphatase; Animals; Brefeldin A; Carrier Proteins; CHO Cells; Cricetinae; Cyclopentanes; Endoplasmic Reticulum; Endoplasmic Reticulum Chaperone BiP; Glycoproteins; Glycosylation; Golgi Apparatus; GPI-Linked Proteins; H-2 Antigens; Heat-Shock Proteins; Humans; Isoenzymes; Molecular Chaperones; Mutagenesis; Oligosaccharides; Temperature | 1997 |
Organization of the receptor-mediated phosphoinositide cycle: relationship between receptor occupancy and accession of phosphatidylinositol.
Topics: Animals; Brefeldin A; Cell Line; Cyclopentanes; Cytochalasin D; Female; Mammary Neoplasms, Experimental; Phosphatidylinositols; Potassium; Rats; Receptors, Cytoplasmic and Nuclear; Signal Transduction; Vasopressins | 1997 |
Cloned dendritic cells can present exogenous antigens on both MHC class I and class II molecules.
Topics: Animals; Antigen Presentation; Antigens, Surface; Bone Marrow Cells; Brefeldin A; Cell Line; Cell Separation; Chloroquine; Clone Cells; Cyclopentanes; Cysteine Endopeptidases; Cytochalasin B; Dendritic Cells; Histocompatibility Antigens Class I; Histocompatibility Antigens Class II; Mice; Mice, Inbred C57BL; Multienzyme Complexes; Ovalbumin; Particle Size; Phagocytosis; Proteasome Endopeptidase Complex | 1997 |
Cell lysis induced by ricin D and ricin E in various cell lines.
Topics: Animals; Binding, Competitive; Brefeldin A; Cell Line; Cells; Chlorocebus aethiops; CHO Cells; Cricetinae; Cycloheximide; Cyclopentanes; Cytotoxins; Dogs; HeLa Cells; Humans; Protein Synthesis Inhibitors; Rats; Ricin; Tumor Cells, Cultured; Vero Cells | 1997 |
Glypican (heparan sulfate proteoglycan) is palmitoylated, deglycanated and reglycanated during recycling in skin fibroblasts.
Topics: Brefeldin A; Cells, Cultured; Cyclopentanes; Fibroblasts; Heparan Sulfate Proteoglycans; Heparitin Sulfate; Humans; Monensin; Palmitic Acid; Polysaccharides; Proteoglycans; Skin; Tritium | 1997 |
Characterization of brefeldin A induced vesicular structures containing cycling proteins of the intermediate compartment/cis-Golgi network.
Topics: Animals; Brefeldin A; Cell Compartmentation; Chlorocebus aethiops; Cyclopentanes; Endoplasmic Reticulum; Galactosyltransferases; Golgi Apparatus; Mannose-Binding Lectins; Mannosidases; Membrane Proteins; Muramidase; Receptors, Peptide; Subcellular Fractions; Vero Cells | 1997 |
Myeloid-related protein (MRP) 8 and MRP14, calcium-binding proteins of the S100 family, are secreted by activated monocytes via a novel, tubulin-dependent pathway.
Topics: Antigens, Differentiation; Brefeldin A; Calcium-Binding Proteins; Calgranulin A; Calgranulin B; Cyclopentanes; Enzyme-Linked Immunosorbent Assay; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; Interferon-gamma; Interleukin-1; Interleukin-4; Interleukin-6; Ionophores; Lipopolysaccharides; Magnetic Resonance Imaging; Models, Biological; Monensin; Monocytes; Protein Conformation; Protein Synthesis Inhibitors; Tubulin; Tumor Necrosis Factor-alpha | 1997 |
Molecular characterisation of an expressed sequence tag locus of Toxoplasma gondii encoding the micronemal protein MIC2.
Topics: Amino Acid Sequence; Animals; Base Sequence; Brefeldin A; Cloning, Molecular; Cyclopentanes; DNA, Complementary; DNA, Protozoan; Escherichia coli; Gene Expression; Genes, Protozoan; Membrane Proteins; Microscopy, Immunoelectron; Molecular Sequence Data; Protozoan Proteins; Recombinant Proteins; Sequence Homology, Amino Acid; Toxoplasma | 1997 |
Brefeldin A-induced alterations in processing of MHC class II-Ii complex depend upon microtubular function.
Topics: Biological Transport; Brefeldin A; Cell Line; Cyclopentanes; Golgi Apparatus; Histocompatibility Antigens Class II; Humans; Microtubules; Nocodazole; Protein Synthesis Inhibitors | 1997 |
Human lactase-phlorizin hydrolase expressed in COS-1 cells is proteolytically processed by the lysosomal pathway.
Topics: Ammonium Chloride; Animals; Brefeldin A; COS Cells; Cyclopentanes; Humans; Lactase-Phlorizin Hydrolase; Lysosomes; Protein Processing, Post-Translational | 1997 |
Role of the disulfide bond in Shiga toxin A-chain for toxin entry into cells.
Topics: Amino Acid Sequence; Bacterial Toxins; Biological Transport; Brefeldin A; Cyclopentanes; Cysteine; Cytotoxins; Disulfides; Dose-Response Relationship, Drug; Female; Golgi Apparatus; Humans; Molecular Sequence Data; Mutagenesis, Site-Directed; Point Mutation; Protein Conformation; Protein Processing, Post-Translational; Serine; Shiga Toxins; Toxicity Tests; Tumor Cells, Cultured | 1997 |
A two-site model for ApoB degradation in HepG2 cells.
Topics: Apolipoproteins B; Biological Transport; Brefeldin A; Cyclopentanes; Cysteine Proteinase Inhibitors; Dithiothreitol; Endoplasmic Reticulum; Humans; Leupeptins; Liver; Models, Biological; Oleic Acid; Peptide Fragments; Protein Synthesis Inhibitors | 1997 |
Identification of intermediate steps in the conversion of a mutant prion protein to a scrapie-like form in cultured cells.
Topics: Animals; Brefeldin A; CHO Cells; Cricetinae; Cyclopentanes; Endopeptidases; Mice; Models, Biological; Mutation; Prion Diseases; Protein Conformation; PrPC Proteins; PrPSc Proteins; Recombinant Proteins; Solubility | 1997 |
Enhanced intracellular dissociation of major histocompatibility complex class I-associated peptides: a mechanism for optimizing the spectrum of cell surface-presented cytotoxic T lymphocyte epitopes.
Topics: Animals; Antigens, Bacterial; Brefeldin A; Cell Line; Cyclopentanes; Endoplasmic Reticulum; Epitopes; Golgi Apparatus; H-2 Antigens; Listeria monocytogenes; Listeriosis; Mice; Peptides; T-Lymphocytes, Cytotoxic | 1997 |
Brefeldin A differently affects basal and prolactin-stimulated milk protein secretion in lactating rabbit mammary epithelial cells.
Topics: Animals; Brefeldin A; Caseins; Cyclopentanes; Epithelium; Female; Fluorescent Antibody Technique, Indirect; Golgi Apparatus; Mammary Glands, Animal; Membrane Proteins; Microscopy, Electron; Prolactin; Protein Synthesis Inhibitors; Rabbits; Rats; Rats, Wistar | 1997 |
Assembly and intracellular targeting of the betagamma subunits of heterotrimeric G proteins.
Topics: Antibodies, Monoclonal; Biological Transport; Brefeldin A; Cell Fractionation; Cell Membrane; Cyclopentanes; Cytosol; Detergents; GTP-Binding Proteins; Humans; Kinetics; Microsomes; Neuroblastoma; Peptide Fragments; Precipitin Tests; Protein Synthesis Inhibitors; Trypsin; Tumor Cells, Cultured | 1997 |
Dissociation of coatomer from membranes is required for brefeldin A-induced transfer of Golgi enzymes to the endoplasmic reticulum.
Topics: Animals; Antibodies; Biological Transport; Biomarkers; Brefeldin A; Chlorocebus aethiops; Coatomer Protein; Cyclopentanes; Endoplasmic Reticulum; Golgi Apparatus; Intracellular Membranes; Membrane Glycoproteins; Microinjections; Microtubule-Associated Proteins; Peptides; Protein Synthesis Inhibitors; Receptors, Peptide; Vero Cells; Vesicular stomatitis Indiana virus; Viral Envelope Proteins | 1997 |
Selective translocation of different markers in the ante- and retrograde pathways between the Golgi apparatus and the rough endoplasmic reticulum in a hybridoma cell line.
Topics: Animals; Biological Transport; Brefeldin A; Cyclopentanes; Endoplasmic Reticulum, Rough; Golgi Apparatus; Hybridomas; Immunoenzyme Techniques; Mice; Microscopy, Electron; Microscopy, Electron, Scanning | 1997 |
Selective increased presentation of type II collagen by leupeptin.
Topics: Animals; Antigen Presentation; Antigen-Presenting Cells; Antigens, Differentiation, B-Lymphocyte; Brefeldin A; Collagen; Cyclopentanes; Dimerization; Epitopes; Histocompatibility Antigens Class II; Immunophenotyping; Leupeptins; Lymphoma, B-Cell; Mice; Mice, Inbred DBA; Protease Inhibitors; Protein Synthesis Inhibitors; Sodium Dodecyl Sulfate; Tumor Cells, Cultured | 1997 |
Receptor-mediated endocytosis of immunoglobulin light chains by renal proximal tubule cells.
Topics: Ammonium Chloride; Animals; Brefeldin A; Cattle; Cell Line; Cell Line, Transformed; Cells, Cultured; Chloroquine; Cyclopentanes; Endocytosis; Enzyme Inhibitors; Female; Humans; Hypertonic Solutions; Immunoglobulin Light Chains; Iodine Radioisotopes; Kidney Tubules, Proximal; Kinetics; Proton-Translocating ATPases; Rats; Rats, Sprague-Dawley; Serum Albumin, Bovine; Simian virus 40; Sucrose; Temperature | 1997 |
Immunocytochemical localization of the Menkes copper transport protein (ATP7A) to the trans-Golgi network.
Topics: Adenosine Triphosphatases; alpha-Mannosidase; Animals; Antibodies; Blotting, Western; Brefeldin A; Carrier Proteins; Cation Transport Proteins; CHO Cells; Copper; Copper Transport Proteins; Copper-Transporting ATPases; Cricetinae; Cyclopentanes; Fibroblasts; Fluorescent Antibody Technique, Indirect; Fungal Proteins; Golgi Apparatus; Hepatolenticular Degeneration; Humans; Mannosidases; Recombinant Fusion Proteins; Saccharomyces cerevisiae Proteins | 1997 |
A membrane network for nutrient import in red cells infected with the malaria parasite.
Topics: Adenosine; Animals; Antimalarials; Biological Transport; Brefeldin A; Cyclopentanes; Erythrocyte Membrane; Erythrocytes; Glutamic Acid; Humans; Intracellular Membranes; Isoquinolines; Morpholines; Nucleosides; Organelles; Orotic Acid; Plasmodium falciparum; Protozoan Proteins; Sphingolipids; Thymidine | 1997 |
Hyposmolality-induced enhancement of ADH action on amiloride-sensitive Isc in renal epithelial A6 cells.
Topics: Amiloride; Brefeldin A; Cell Line; Cyclopentanes; Diuretics; Electric Conductivity; Epithelial Cells; Epithelium; Hypotonic Solutions; Kidney; Osmolar Concentration; Protein Synthesis Inhibitors; Renal Agents; Vasopressins | 1997 |
Characterization of chemical inhibitors of brefeldin A-activated mono-ADP-ribosylation.
Topics: Adenosine Diphosphate; Animals; Brefeldin A; Cell Line; Cyclopentanes; Glyceraldehyde-3-Phosphate Dehydrogenases; GTP-Binding Proteins; Male; Protein Processing, Post-Translational; Protein Synthesis Inhibitors; Rats; Rats, Sprague-Dawley; Ribose; Structure-Activity Relationship; Tissue Distribution | 1997 |
Bcl-2 does not require Raf kinase activity for its death-protective function.
Topics: Animals; Apoptosis; Brefeldin A; Calcium-Calmodulin-Dependent Protein Kinases; Cell Division; Cell Survival; Cells, Cultured; Chloramphenicol O-Acetyltransferase; Cloning, Molecular; Cyclic AMP; Cyclopentanes; Enzyme Inhibitors; Fibroblasts; Humans; Kinetics; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Proto-Oncogene Proteins c-raf; Rats; Recombinant Fusion Proteins; Signal Transduction; Staurosporine; Transfection | 1997 |
Yersinia enterocolitica serotype O:3 alters the expression of serologic HLA-B27 epitopes on human monocytes.
Topics: Brefeldin A; Cyclopentanes; Epitopes; HLA-B27 Antigen; Humans; Monocytes; Phagocytosis; Yersinia enterocolitica | 1997 |
Tight junction assembly during mouse blastocyst formation is regulated by late expression of ZO-1 alpha+ isoform.
Topics: Alternative Splicing; Animals; Antibody Specificity; Blastocyst; Brefeldin A; Cell Communication; Cell Membrane; Cyclopentanes; Epithelium; Gene Expression Regulation, Developmental; Membrane Proteins; Mice; Morula; Occludin; Oocytes; Phosphoproteins; Phosphorylation; Protein Synthesis Inhibitors; RNA, Messenger; Tight Junctions; Zonula Occludens-1 Protein | 1997 |
Poliovirus RNA recombination in cell-free extracts.
Topics: Antiviral Agents; Benzimidazoles; Brefeldin A; Cell-Free System; Cyclopentanes; Genetic Techniques; HeLa Cells; Humans; Oximes; Poliovirus; Recombination, Genetic; RNA, Viral; Sulfonamides | 1997 |
Endocytosis and retrograde transport of pertussis toxin to the Golgi complex as a prerequisite for cellular intoxication.
Topics: Adenosine Diphosphate Ribose; Animals; Biological Transport, Active; Brefeldin A; Cell Line; CHO Cells; Cricetinae; Cyclopentanes; Dogs; Endocytosis; Golgi Apparatus; Mutation; Pertussis Toxin; Subcellular Fractions; Temperature; Virulence Factors, Bordetella | 1997 |
Membrane association, localization and topology of rat inositol 1,4,5-trisphosphate 3-kinase B: implications for membrane traffic and Ca2+ homoeostasis.
Topics: Amino Acid Sequence; Animals; Blotting, Western; Brefeldin A; Calcium; Carbonates; Carrier Proteins; Cell Membrane; COS Cells; Cyclopentanes; Cytosol; DNA, Complementary; Endoplasmic Reticulum; Fluorescent Antibody Technique, Indirect; Homeostasis; Humans; Ion Transport; Isoenzymes; Maltose-Binding Proteins; Membrane Proteins; Microscopy, Immunoelectron; Molecular Sequence Data; Phosphotransferases (Alcohol Group Acceptor); Protein Conformation; Rats; Recombinant Fusion Proteins; Sodium Chloride; Transfection; Urea | 1997 |
A simple and rapid technique for the immunofluorescence confocal microscopy of intact Arabidopsis root tips.
Topics: Arabidopsis; Brefeldin A; Cyclopentanes; Fluorescent Antibody Technique; Microscopy, Confocal; Microtubules; Mitosis; Plant Roots; Spindle Apparatus | 1996 |
Aberrant O-glycosylation in the collagenous domain of pro alpha2(I) procollagen subunits synthesized by chemically transformed hamster fibroblasts.
Topics: Acetylgalactosamine; Animals; Benzyl Compounds; Binding Sites; Brefeldin A; Cell Line, Transformed; Collagen; Cricetinae; Cyclopentanes; Enzyme Inhibitors; Glycoside Hydrolases; Glycosylation; Isoelectric Focusing; Monensin; Procollagen | 1997 |
Golgi membrane skeleton: identification, localization and oligomerization of a 195 kDa ankyrin isoform associated with the Golgi complex.
Topics: Animals; Ankyrins; Antibody Specificity; Brefeldin A; Cell Line; Cyclopentanes; Dogs; Erythrocytes; Golgi Apparatus; Humans; Intracellular Membranes; Microscopy, Immunoelectron; Microtubules; Mitosis; Molecular Weight; Rats; Spectrin | 1997 |
Possible role of BARS-50, a substrate of brefeldin A-dependent mono-ADP-ribosylation, in intracellular transport.
Topics: Adenosine Diphosphate Ribose; Animals; Biological Transport; Brefeldin A; Cell Line; Cyclopentanes; GTP-Binding Proteins; Rats; Substrate Specificity | 1997 |
Brefeldin A-induced ADP-ribosylation in the structure and function of the Golgi complex.
Topics: Adenosine Diphosphate Ribose; Brefeldin A; Cyclopentanes; Golgi Apparatus | 1997 |
Characterization of the endogenous mono-ADP-ribosylation stimulated by brefeldin A.
Topics: Adenosine Diphosphate Ribose; Brefeldin A; Cyclopentanes; Glyceraldehyde-3-Phosphate Dehydrogenases; GTP-Binding Proteins | 1997 |
Intracellular generation and accumulation of amyloid beta-peptide terminating at amino acid 42.
Topics: Amyloid beta-Peptides; Brefeldin A; Cell Line; Cyclopentanes; Endoplasmic Reticulum; Humans; Kidney | 1997 |
Evidence for a dual control of macroautophagic sequestration and intracellular trafficking of N-linked glycoproteins by the trimeric G(i3) protein in HT-29 cells.
Topics: Adenine; Autophagy; Brefeldin A; Cyclopentanes; Exocytosis; Glycoproteins; Golgi Apparatus; GTP-Binding Protein alpha Subunits, Gi-Go; HT29 Cells; Humans; Lysosomes; Mutation; Pertussis Toxin; Polysaccharides; Raffinose; Transfection; Virulence Factors, Bordetella | 1997 |
Transient accumulation of proteins at interrod and rod enamel growth sites.
Topics: Ameloblasts; Amelogenesis; Amelogenin; Animals; Brefeldin A; Cycloheximide; Cyclopentanes; Dental Enamel; Dental Enamel Proteins; Immunohistochemistry; Incisor; Lectins; Male; Protein Synthesis Inhibitors; Rats; Rats, Wistar | 1996 |
The effect of brefeldin A on terbutaline-induced sodium absorption in fetal rat distal lung epithelium.
Topics: Absorption; Amiloride; Animals; Brefeldin A; Cations; Cyclopentanes; Epithelium; Fetus; Ion Channels; Lung; Patch-Clamp Techniques; Rats; Rats, Wistar; Sodium; Sodium-Potassium-Exchanging ATPase; Terbutaline | 1997 |
Effects of brefeldin A on the expression and transport of influenza A virus haemagglutinin, M1 and M2 proteins within the cell.
Topics: Animals; Antigens, Surface; Biological Transport; Brefeldin A; Cell Compartmentation; Cell Line; Cyclopentanes; Dogs; Hemagglutinins, Viral; Immunohistochemistry; Ion Channels; Membrane Proteins; Viral Matrix Proteins | 1997 |
Glycosylation and secretion of lipoprotein lipase by 3T3-L1 adipocytes: effects of brefeldin A.
Topics: Adipocytes; Animals; Brefeldin A; Cell Line; Cyclopentanes; Glycosylation; Lipoprotein Lipase; Mice; Protein Synthesis Inhibitors | 1995 |
Localization of human heparan glucosaminyl N-deacetylase/N-sulphotransferase to the trans-Golgi network.
Topics: Amidohydrolases; Animals; Antibodies, Monoclonal; Blotting, Western; Brefeldin A; Cell Line; Cloning, Molecular; Cyclopentanes; Endothelium, Vascular; Epitopes; Fluorescent Antibody Technique; Golgi Apparatus; Heparin; Heparitin Sulfate; Humans; Mice; Microscopy, Fluorescence; Oligopeptides; Peptides; RNA, Messenger; Sulfotransferases; Umbilical Veins | 1997 |
Transcytosis of albumin in endothelial cells is brefeldin A--independent.
Topics: Animals; Aorta; Biological Transport; Brefeldin A; Cattle; Cell Culture Techniques; Cell Membrane Permeability; Cells, Cultured; Colforsin; Cyclopentanes; Endocytosis; Endothelium, Vascular; Fluorescent Dyes; Horseradish Peroxidase; Serum Albumin, Bovine; Xanthenes | 1997 |
Binding of copolymer 1 and myelin basic protein leads to clustering of class II MHC molecules on antigen-presenting cells.
Topics: Adjuvants, Immunologic; Amino Acid Sequence; Animals; Antigen-Presenting Cells; B-Lymphocytes; Brefeldin A; Cell Line, Transformed; Cycloheximide; Cyclopentanes; Gene Expression Regulation; Glatiramer Acetate; Histocompatibility Antigens Class I; HLA Antigens; HLA-D Antigens; Humans; Immunosuppressive Agents; Mice; Molecular Sequence Data; Myelin Basic Protein; Peptides; Polymers; Protein Binding; Protein Synthesis Inhibitors; Receptor Aggregation | 1997 |
ATP-dependent formation of free synaptic vesicles from PC12 membranes in vitro.
Topics: Adenosine Triphosphate; Aluminum Compounds; Animals; Brefeldin A; Cell-Free System; Cyclopentanes; Cytosol; Enzyme-Linked Immunosorbent Assay; Ethylmaleimide; Fluorides; Guanosine 5'-O-(3-Thiotriphosphate); In Vitro Techniques; PC12 Cells; Protein Synthesis Inhibitors; Rats; Synaptic Vesicles; Temperature | 1997 |
ADP ribosylation factor 1 is required for synaptic vesicle budding in PC12 cells.
Topics: ADP-Ribosylation Factor 1; ADP-Ribosylation Factors; Animals; Anti-Bacterial Agents; Antigens, Viral, Tumor; Brefeldin A; Cell Membrane; Cell-Free System; Cyclopentanes; Endocytosis; Endosomes; Enzyme Inhibitors; GTP-Binding Proteins; Humans; Macrolides; Membrane Proteins; Morphogenesis; Mutation; PC12 Cells; Quinones; R-SNARE Proteins; Rats; Recombinant Proteins; Synaptic Vesicles; Transferrin | 1997 |
Novel beta-secretase cleavage of beta-amyloid precursor protein in the endoplasmic reticulum/intermediate compartment of NT2N cells.
Topics: Amyloid beta-Protein Precursor; Amyloid Precursor Protein Secretases; Animals; Aspartic Acid Endopeptidases; Brefeldin A; Cell Compartmentation; CHO Cells; Cricetinae; Cyclopentanes; Endopeptidases; Endoplasmic Reticulum; Glycosylation; Golgi Apparatus; Humans; Neurons; Peptide Fragments; Protein Processing, Post-Translational; Tumor Cells, Cultured | 1997 |
Brefeldin A interferes with peroxisomal protein sorting in the yeast Hansenula polymorpha.
Topics: Biological Transport; Brefeldin A; Cyclopentanes; Endoplasmic Reticulum; Glucose; Microbodies; Pichia; Protein Synthesis Inhibitors | 1997 |
Fluorescence recovery after photobleaching (FRAP) of a fluorescent transferrin internalized in the late transferrin endocytic compartment of living A431 cells: experiments.
Topics: Aluminum Compounds; Biological Transport, Active; Brefeldin A; Cell Membrane; Cyclopentanes; Endocytosis; Fluorescent Dyes; Fluorides; Humans; Nocodazole; Rhodamines; Transferrin; Tumor Cells, Cultured | 1997 |
Functional protein prenylation is required for the brefeldin A-dependent retrograde transport from the Golgi apparatus to the endoplasmic reticulum.
Topics: Animals; Biological Transport; Brefeldin A; Carrier Proteins; Cyclopentanes; Endoplasmic Reticulum; Golgi Apparatus; Guanosine Triphosphate; Lovastatin; Protein Prenylation; rab GTP-Binding Proteins; Rabbits; ras Proteins; Rats | 1997 |
A novel alternate secretory pathway for the export of Plasmodium proteins into the host erythrocyte.
Topics: Animals; Biological Transport; Brefeldin A; Cyclopentanes; Erythrocytes; Host-Parasite Interactions; Immunohistochemistry; Mice; Plasmodium; Protein Synthesis Inhibitors; Protozoan Proteins; Signal Transduction | 1997 |
Intracellular degradation of secretion defect-type mutants of antithrombin is inhibited by proteasomal inhibitors.
Topics: Acetylcysteine; Animals; Antithrombin III; Brefeldin A; Cell Line; Cricetinae; Cyclopentanes; Cysteine Endopeptidases; Electrophoresis, Polyacrylamide Gel; Endoplasmic Reticulum; Enzyme Inhibitors; Fluorescent Antibody Technique; Golgi Apparatus; Humans; Kidney; Leupeptins; Multienzyme Complexes; Mutagenesis, Site-Directed; Protease Inhibitors; Proteasome Endopeptidase Complex; Protein Synthesis Inhibitors; Transfection | 1997 |
Internalized plasma membrane cholesterol passes through an endosome compartment that is distinct from the acid vesicle-lysosome compartment.
Topics: 4-Chloro-7-nitrobenzofurazan; Animals; Brefeldin A; Bucladesine; Cell Fractionation; Cell Membrane; Chloroquine; Cholesterol; Cholesterol Esters; Cholesterol, LDL; Cyclopentanes; Endosomes; Fluorescent Dyes; Golgi Apparatus; Leydig Cell Tumor; Lysosomes; Mice; Progesterone; Protein Synthesis Inhibitors; Sphingosine; Tumor Cells, Cultured | 1997 |
Endoplasmic reticulum to Golgi trafficking in multinucleated skeletal muscle fibers.
Topics: Animals; Brefeldin A; Cell Nucleus; Cyclopentanes; Endoplasmic Reticulum; Golgi Apparatus; Intercellular Junctions; Isomerases; Membrane Glycoproteins; Microtubule Proteins; Microtubules; Motor Endplate; Muscle Fibers, Skeletal; Muscle, Skeletal; Mutation; Protein Disulfide-Isomerases; Rats; Temperature; Vesicular stomatitis Indiana virus; Viral Envelope Proteins | 1997 |
Effects of cadmium, copper, and zinc and beta APP processing and turnover in COS-7 and PC12 cells. Relationship to Alzheimer disease pathology.
Topics: Amyloid beta-Peptides; Amyloid Precursor Protein Secretases; Animals; Brefeldin A; Cadmium Chloride; Cell Compartmentation; Chlorides; Copper Sulfate; COS Cells; Cyclopentanes; Endopeptidases; Endoplasmic Reticulum; Golgi Apparatus; Kinetics; PC12 Cells; Protein Synthesis Inhibitors; Rats; RNA, Messenger; Zinc Compounds | 1997 |
MHC class I presentation of an exogenous polypeptide antigen encoded by the murine AIDS defective virus.
Topics: Acetylcysteine; Amino Acid Sequence; Animals; Antigen Presentation; Antiviral Agents; Brefeldin A; Cathepsin B; CD8-Positive T-Lymphocytes; Cyclopentanes; Cysteine Proteinase Inhibitors; Cytochalasin B; Cytochalasin D; Dipeptides; Female; Gene Products, gag; H-2 Antigens; Interleukin-2; Leukemia Virus, Murine; Major Histocompatibility Complex; Mice; Mice, Inbred C57BL; Molecular Sequence Data; Murine Acquired Immunodeficiency Syndrome; Nucleic Acid Synthesis Inhibitors; Plant Proteins; Protein Synthesis Inhibitors; Ribosome Inactivating Proteins, Type 1 | 1997 |
MHC class II-associated invariant chain-induced enlarged endosomal structures: a morphological study.
Topics: Adenine; Antigens, CD; Brefeldin A; Cell Line; Chloroquine; Cyclopentanes; Endocytosis; Endosomes; Fibroblasts; HLA-DR alpha-Chains; HLA-DR Antigens; Humans; Immunohistochemistry; Leupeptins; Lysosomal Membrane Proteins; Lysosomes; Macromolecular Substances; Membrane Glycoproteins; Receptor, IGF Type 2; Recombinant Proteins; Transfection | 1997 |
Cysteine and glutathione secretion in response to protein disulfide bond formation in the ER.
Topics: Animals; Benzopyrans; Brefeldin A; Cycloheximide; Cyclopentanes; Cysteine; Cystine; Disulfides; Endoplasmic Reticulum; Exocytosis; Glutathione; Glutathione Disulfide; Golgi Apparatus; Hemagglutinin Glycoproteins, Influenza Virus; Immunoglobulin lambda-Chains; Immunoglobulin M; Oocytes; Oxidation-Reduction; Protein Synthesis Inhibitors; Proteins; Temperature; Tumor Cells, Cultured; Xenopus laevis | 1997 |
Alzheimer's A beta(1-42) is generated in the endoplasmic reticulum/intermediate compartment of NT2N cells.
Topics: Alzheimer Disease; Amino Acid Sequence; Amyloid beta-Peptides; Base Sequence; Brefeldin A; Cell Compartmentation; Cell Line; Cyclopentanes; DNA Primers; Endoplasmic Reticulum; Humans; Microscopy, Fluorescence; Mutagenesis, Site-Directed; Neurons; Peptide Fragments; Protein Synthesis Inhibitors | 1997 |
The biosynthesis and secretion of prostate-specific antigen in LNCaP cells.
Topics: 1-Deoxynojirimycin; Biological Transport; Brefeldin A; Chloroquine; Cyclopentanes; Dihydrotestosterone; Dithiothreitol; Endoplasmic Reticulum; Golgi Apparatus; Humans; Male; Neoplasm Proteins; Pilocarpine; Precipitin Tests; Prostate-Specific Antigen; Protein Synthesis Inhibitors; Saponins; Tumor Cells, Cultured; Tunicamycin | 1997 |
Molecular characterization of GCP170, a 170-kDa protein associated with the cytoplasmic face of the Golgi membrane.
Topics: Amino Acid Sequence; Animals; Autoantigens; Brefeldin A; Cloning, Molecular; COS Cells; Cricetinae; Cyclopentanes; Cytoplasm; DNA, Complementary; Golgi Apparatus; Golgi Matrix Proteins; Humans; Intracellular Membranes; Membrane Proteins; Microtubules; Molecular Sequence Data; Phosphorylation; Tumor Cells, Cultured | 1997 |
Vasorelaxant properties of brefeldin A in rat aorta.
Topics: Adrenergic alpha-Agonists; Animals; Anti-Bacterial Agents; Aorta; Brefeldin A; Calcium; Calcium Channels; Cyclopentanes; Dose-Response Relationship, Drug; In Vitro Techniques; Macrolides; Male; Muscle, Smooth, Vascular; Myocardial Contraction; Phenylephrine; Rats; Rats, Wistar | 1997 |
Rapid movement of newly synthesized chicken apolipoprotein AI to trans-Golgi network and its secretion in Madin-Darby canine kidney cells.
Topics: Animals; Apolipoprotein A-I; Biological Transport; Brefeldin A; Cell Line; Cell Polarity; Chickens; Cyclopentanes; Dogs; Endoplasmic Reticulum, Rough; Epithelial Cells; Golgi Apparatus; Hexosaminidases; Kidney; Protein Synthesis Inhibitors | 1997 |
Detoxification mechanism in the rat extraorbital lacrimal gland: conjugation of brefeldin A to glutathione.
Topics: Animals; Brefeldin A; Chromatography, High Pressure Liquid; Cyclopentanes; Cysteine; Enzyme Inhibitors; Glutathione; Inactivation, Metabolic; Isoxazoles; Lacrimal Apparatus; Male; Rats; Rats, Sprague-Dawley | 1997 |
MEK kinases are regulated by EGF and selectively interact with Rac/Cdc42.
Topics: Animals; Blotting, Western; Brefeldin A; Calcium-Calmodulin-Dependent Protein Kinases; cdc42 GTP-Binding Protein; Cell Cycle Proteins; CHO Cells; Cloning, Molecular; Cricetinae; Cyclopentanes; Enzyme Activation; Epidermal Growth Factor; GTP-Binding Proteins; JNK Mitogen-Activated Protein Kinases; MAP Kinase Kinase 3; MAP Kinase Kinase 4; MAP Kinase Kinase Kinase 1; Microscopy, Fluorescence; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase Kinases; Models, Biological; Protein Kinases; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Signal Transduction | 1997 |
ARF is not required for nuclear vesicle fusion or mitotic membrane disassembly in vitro: evidence for a non-ARF GTPase in fusion.
Topics: ADP-Ribosylation Factor 1; ADP-Ribosylation Factors; Animals; Brefeldin A; Cyclopentanes; Cytosol; GTP Phosphohydrolases; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Membrane Fusion; Mitosis; Nuclear Envelope; Protein Synthesis Inhibitors; Rats; Xenopus laevis | 1997 |
Human Rer1 is localized to the Golgi apparatus and complements the deletion of the homologous Rer1 protein of Saccharomyces cerevisiae.
Topics: Adaptor Proteins, Vesicular Transport; Amino Acid Sequence; Brefeldin A; Cloning, Molecular; Cyclopentanes; Fungal Proteins; Genetic Complementation Test; Golgi Apparatus; Guanine Nucleotide Exchange Factors; HeLa Cells; Humans; Mannose-Binding Lectins; Membrane Glycoproteins; Membrane Proteins; Molecular Sequence Data; Protein Synthesis Inhibitors; Receptors, Peptide; Recombinant Fusion Proteins; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Sequence Analysis, DNA; Sequence Homology, Amino Acid; Vesicular Transport Proteins | 1997 |
Direct measurement of endosomal pH in living cells of the rat yolk sac epithelium by laser confocal microscopy.
Topics: Animals; Brefeldin A; Cyclopentanes; Endocytosis; Endosomes; Epithelium; Fluorescein; Fluorescent Dyes; Horseradish Peroxidase; Hydrogen-Ion Concentration; Microscopy, Confocal; Protein Synthesis Inhibitors; Rats; Rats, Wistar; Rhodamines; Vacuoles; Yolk Sac | 1997 |
Effects of brefeldin A on autophagy in cultured rat fibroblasts.
Topics: Acid Phosphatase; Animals; Autophagy; Brefeldin A; Cells, Cultured; Cyclopentanes; Fibroblasts; Golgi Apparatus; Protein Synthesis Inhibitors; Rats; Thiamine Pyrophosphatase; Vacuoles | 1997 |
Synthesis, secretion, degradation, and fate of ameloblastin during the matrix formation stage of the rat incisor as shown by immunocytochemistry and immunochemistry using region-specific antibodies.
Topics: Ameloblasts; Animals; Blotting, Western; Brefeldin A; Cyclopentanes; Cytoplasmic Granules; Dental Enamel Proteins; Enamel Organ; Gene Expression; Golgi Apparatus; Immunohistochemistry; Incisor; Male; Microscopy, Immunoelectron; Peptide Fragments; Protein Synthesis Inhibitors; Rats; Rats, Wistar | 1997 |
ARF-independent inhibition of the carbachol-induced contractions by brefeldin A in intestinal smooth muscle.
Topics: ADP-Ribosylation Factor 1; ADP-Ribosylation Factors; Animals; Brefeldin A; Calcium Channel Blockers; Calcium Channels; Carbachol; Cyclopentanes; GTP-Binding Proteins; GTPase-Activating Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Ileum; In Vitro Techniques; Membrane Potentials; Muscle Contraction; Rats; Rats, Wistar | 1997 |
The activity of the epithelial sodium channel is regulated by clathrin-mediated endocytosis.
Topics: Amiloride; Animals; Brefeldin A; Clathrin; Cyclopentanes; Diuretics; Endocytosis; Epithelial Sodium Channels; Epithelium; Half-Life; Hypertension; Oocytes; Protein Synthesis Inhibitors; Rats; Sodium Channels; Xenopus | 1997 |
Endoplasmic reticulum quality control of asialoglycoprotein receptor H2a involves a determinant for retention and not retrieval.
Topics: 3T3 Cells; Amino Acid Sequence; Animals; Asialoglycoprotein Receptor; Brefeldin A; Calcium-Binding Proteins; Calnexin; Carbohydrate Sequence; Cell Membrane; Cyclopentanes; Endoplasmic Reticulum; Golgi Apparatus; Humans; Macromolecular Substances; Mice; Molecular Chaperones; Molecular Sequence Data; Nocodazole; Peptide Fragments; Protein Folding; Receptors, Cell Surface; Recombinant Proteins; Sequence Alignment; Swainsonine; Transfection | 1997 |
Decreased reverse cholesterol transport from Tangier disease fibroblasts. Acceptor specificity and effect of brefeldin on lipid efflux.
Topics: Adult; Apolipoprotein A-I; Apolipoproteins; Biological Transport, Active; Brefeldin A; Cells, Cultured; Cholesterol; Cholesterol, HDL; Cyclopentanes; Female; Fibroblasts; Humans; Lipid Metabolism; Phospholipids; Reference Values; Skin; Tangier Disease | 1997 |
Alzheimer's disease-associated presenilin 1 in neuronal cells: evidence for localization to the endoplasmic reticulum-Golgi intermediate compartment.
Topics: Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Antibodies, Monoclonal; Antibody Specificity; Biological Transport; Biomarkers; Brefeldin A; Cell Compartmentation; Cerebellum; CHO Cells; Cricetinae; Cyclopentanes; Endoplasmic Reticulum; Fluorescent Antibody Technique; Golgi Apparatus; Hippocampus; Humans; Mannose-Binding Lectins; Membrane Proteins; Neuroblastoma; Neurons; Presenilin-1; Protein Synthesis Inhibitors; Rabbits; Rats; Rats, Sprague-Dawley; Tumor Cells, Cultured | 1997 |
S-Acylation and plasma membrane targeting of the farnesylated carboxyl-terminal peptide of N-ras in mammalian fibroblasts.
Topics: 4-Chloro-7-nitrobenzofurazan; Acylation; Amino Acid Sequence; Animals; Brefeldin A; Cell Line; Cell Membrane; Cold Temperature; Cyclopentanes; Fibroblasts; Genes, ras; Kinetics; Liposomes; Mammals; Peptide Fragments; Protein Prenylation; Protein Synthesis Inhibitors; Proto-Oncogene Proteins p21(ras) | 1997 |
O-Glycosylation of C-terminal tandem-repeated sequences regulates the secretion of rat pancreatic bile salt-dependent lipase.
Topics: Amino Acid Sequence; Animals; Brefeldin A; CHO Cells; Cricetinae; Cyclopentanes; DNA Probes; Galactose; Glutamic Acid; Glycosylation; Kinetics; Lipase; Monensin; Pancreas; Peptide Fragments; Proline; Rats; Recombinant Proteins; Serine; Sterol Esterase; Threonine; Transfection | 1997 |
Biosynthesis of the proteoglycan decorin -- identification of intermediates in galactosaminoglycan assembly.
Topics: Amino Acid Sequence; Animals; Brefeldin A; Cell Line; Chromatography, Gel; Cyclopentanes; Decorin; Disaccharides; Extracellular Matrix Proteins; Fibroblasts; Methionine; Molecular Sequence Data; Oligosaccharides; Polysaccharides; Protein Precursors; Protein Synthesis Inhibitors; Proteoglycans; Rats; Sulfates; Sulfur Radioisotopes | 1997 |
Biosynthesis of the proteoglycan decorin--transient 2-phosphorylation of xylose during formation of the trisaccharide linkage region.
Topics: Animals; Brefeldin A; Carbohydrate Conformation; Carbohydrate Sequence; Chondroitin ABC Lyase; Cyclopentanes; Decorin; Extracellular Matrix Proteins; Fibroblasts; Galactose; Glucosamine; Glucuronates; Glucuronic Acid; Glucuronidase; Molecular Sequence Data; Phosphates; Phosphorylation; Protein Synthesis Inhibitors; Proteoglycans; Rats; Trisaccharides; Xylose | 1997 |
Intracellular transport, cell-surface exposure and release of recombinant Tamm-Horsfall glycoprotein.
Topics: Biological Transport; Brefeldin A; Cyclopentanes; HeLa Cells; Hexosamines; Humans; Mercaptoethanol; Monensin; Mucoproteins; Recombinant Proteins; Uromodulin | 1997 |
Extensive cellular uptake into endothelial cells of an amphipathic beta-sheet forming peptide.
Topics: Amino Acid Sequence; Animals; Aorta; Biological Transport; Brefeldin A; Cattle; Cell Survival; Cells, Cultured; Cyclopentanes; Deoxyglucose; Endothelium, Vascular; Fluoresceins; Fluorescent Dyes; Hydrogen-Ion Concentration; Isoquinolines; Molecular Sequence Data; Monensin; Peptides; Protein Structure, Secondary; Proteins; Solubility; Temperature; Vincristine | 1997 |
Regulation of stability and function of the epithelial Na+ channel (ENaC) by ubiquitination.
Topics: Acetylcysteine; Amino Acid Sequence; Animals; Brefeldin A; Calcium-Binding Proteins; Cell Line; Chloroquine; Cyclopentanes; Cysteine Endopeptidases; Dogs; Endosomal Sorting Complexes Required for Transport; Endosomes; Epithelial Sodium Channels; Epithelium; Half-Life; Ion Channel Gating; Ion Transport; Ligases; Lysosomes; Molecular Sequence Data; Multienzyme Complexes; Mutagenesis, Site-Directed; Mutation; Nedd4 Ubiquitin Protein Ligases; Nuclear Magnetic Resonance, Biomolecular; Oocytes; Point Mutation; Protease Inhibitors; Proteasome Endopeptidase Complex; Protein Conformation; Protein Processing, Post-Translational; Rats; Recombinant Fusion Proteins; Sodium; Sodium Channels; Transfection; Ubiquitin-Protein Ligases; Ubiquitins; Up-Regulation; Xenopus laevis; Xenopus Proteins | 1997 |
Incorporation of copper into lysyl oxidase.
Topics: Bone Morphogenetic Protein 1; Bone Morphogenetic Proteins; Brefeldin A; Copper; Cycloheximide; Cyclopentanes; DNA, Complementary; Enzyme Inhibitors; Fibroblasts; Glycosylation; Metalloendopeptidases; Protein Biosynthesis; Protein Processing, Post-Translational; Protein Synthesis Inhibitors; Protein-Lysine 6-Oxidase; Transcription, Genetic; Tunicamycin | 1997 |
alpha-tocopherol transfer protein stimulates the secretion of alpha-tocopherol from a cultured liver cell line through a brefeldin A-insensitive pathway.
Topics: Animals; Brefeldin A; Carrier Proteins; Cyclopentanes; Gene Expression; Liver; Liver Neoplasms, Experimental; Rats; Signal Transduction; Tumor Cells, Cultured; Vitamin E | 1997 |
Distinct molecular events during secretory granule biogenesis revealed by sensitivities to brefeldin A.
Topics: Animals; Brefeldin A; Cyclopentanes; Cytoplasmic Granules; Endoribonucleases; Glycosaminoglycans; Glycosylation; Golgi Apparatus; Mice; Monensin; Oligosaccharides; Pituitary Gland, Anterior; Pituitary Neoplasms; Pro-Opiomelanocortin; Protein Processing, Post-Translational; Protein Synthesis Inhibitors; Ribonucleases; Sulfates; Tumor Cells, Cultured | 1997 |
Inhibition of axonal growth by brefeldin A in hippocampal neurons in culture.
Topics: Animals; Axonal Transport; Axons; Brefeldin A; Cell Membrane; Cell Polarity; Cells, Cultured; Cyclopentanes; Golgi Apparatus; Hippocampus; Membrane Proteins; Nerve Tissue Proteins; Protein Synthesis Inhibitors; Rats | 1997 |
Overexpression of MAP4 inhibits organelle motility and trafficking in vivo.
Topics: Biological Transport; Brefeldin A; Cell Line; Cyclopentanes; Microtubule-Associated Proteins; Organelles; Transferrin | 1997 |
Degradation of connexin43 gap junctions involves both the proteasome and the lysosome.
Topics: Animals; Brefeldin A; Cells, Cultured; Connexin 43; Cyclopentanes; Cysteine Endopeptidases; Fluorescent Antibody Technique; Gap Junctions; Lysosomes; Models, Biological; Monensin; Multienzyme Complexes; Myocardium; Protease Inhibitors; Proteasome Endopeptidase Complex; Rats | 1997 |
Human cystatin C forms an inactive dimer during intracellular trafficking in transfected CHO cells.
Topics: Animals; Brefeldin A; Cells, Cultured; CHO Cells; Clone Cells; Cricetinae; Cycloheximide; Cyclopentanes; Cystatin C; Cystatins; Cysteine Proteinase Inhibitors; Dimerization; Endoplasmic Reticulum; Enzyme-Linked Immunosorbent Assay; Fluorescent Antibody Technique; Humans; Lysosomes; Organelles; Papain; Recombinant Proteins; Skin; Transfection | 1997 |
Evidence that a low-molecular-mass GTP-binding protein is required for store-activated Ca2+ inflow in hepatocytes.
Topics: ADP-Ribosylation Factors; Animals; Brefeldin A; Calcium; Cyclopentanes; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Triphosphate; Inositol 1,4,5-Trisphosphate; Ion Transport; Liver; Peptide Fragments; Rats; Thapsigargin; Vasopressins | 1997 |
Use of photoactivatable sphingolipid analogues to monitor lipid transport in mammalian cells.
Topics: Animals; Biological Transport; Brefeldin A; Carrier Proteins; Cell Line; Cricetinae; Cyclopentanes; Glucosylceramides; Humans; Lipid Metabolism; Photoaffinity Labels; Sphingolipids; Sphingomyelins | 1997 |
Cloning and expression of a cDNA encoding a bovine brain brefeldin A-sensitive guanine nucleotide-exchange protein for ADP-ribosylation factor.
Topics: ADP-Ribosylation Factor 1; ADP-Ribosylation Factors; Amino Acid Sequence; Animals; Base Sequence; Brain; Brefeldin A; Cattle; Cloning, Molecular; Cyclopentanes; DNA, Complementary; GTP-Binding Proteins; Guanine Nucleotide Exchange Factors; Molecular Sequence Data; Proteins; Recombinant Proteins; RNA, Messenger; Sequence Homology, Amino Acid; Spodoptera | 1997 |
Myosin II is associated with Golgi membranes: identification of p200 as nonmuscle myosin II on Golgi-derived vesicles.
Topics: Actins; Amino Acid Sequence; Animals; Antibodies, Monoclonal; Antibody Specificity; Biological Transport; Brefeldin A; Chick Embryo; Cyclopentanes; Cytosol; Epitopes; Golgi Apparatus; GTP-Binding Proteins; HeLa Cells; Humans; Immunohistochemistry; Intracellular Membranes; Kidney; Microscopy, Immunoelectron; Myosins; Protein Binding; Protein Synthesis Inhibitors | 1997 |
Role of NAD+ and ADP-ribosylation in the maintenance of the Golgi structure.
Topics: Adenosine Diphosphate Ribose; Animals; Brefeldin A; Cell Membrane Permeability; Coatomer Protein; Cyclopentanes; Endoplasmic Reticulum; Golgi Apparatus; Membrane Proteins; NAD; Rats; Tumor Cells, Cultured | 1997 |
Involvement of the transmembrane protein p23 in biosynthetic protein transport.
Topics: Amino Acid Sequence; Animals; Biological Transport; Brefeldin A; Cell Compartmentation; Cell Fractionation; Cell Polarity; CHO Cells; Cloning, Molecular; Coatomer Protein; Cricetinae; Cyclopentanes; DNA, Complementary; Endoplasmic Reticulum; Fluorescent Antibody Technique; Golgi Apparatus; Membrane Glycoproteins; Membrane Proteins; Microscopy, Immunoelectron; Microtubules; Molecular Sequence Data; Nocodazole; Protein Binding; Receptors, Cytoplasmic and Nuclear; Sequence Analysis, DNA; Viral Envelope Proteins | 1997 |
Golgi tubule traffic and the effects of brefeldin A visualized in living cells.
Topics: Animals; Biological Transport; Brefeldin A; CHO Cells; Computer Simulation; Cricetinae; Cyclopentanes; Fluorescent Antibody Technique; Golgi Apparatus; Green Fluorescent Proteins; HeLa Cells; Humans; Image Processing, Computer-Assisted; Luminescent Proteins; Membrane Fluidity; Microscopy, Immunoelectron; Microscopy, Video; Microtubules; Models, Biological; Models, Theoretical; Nocodazole; Recombinant Fusion Proteins; Rheology | 1997 |
Effects of brefeldin A on phosphatidylcholine phospholipase D and inositolphospholipid metabolism in HL-60 cells.
Topics: Adenosine Triphosphate; ADP-Ribosylation Factors; Brefeldin A; Cyclopentanes; Enzyme Activation; Enzyme Inhibitors; Galactosyltransferases; Golgi Apparatus; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); HL-60 Cells; Humans; Inositol Phosphates; Kinetics; N-Formylmethionine Leucyl-Phenylalanine; Phosphatidylcholines; Phosphatidylinositols; Phospholipase D; Tetradecanoylphorbol Acetate; Type C Phospholipases | 1997 |
The subcellular sites of sphingomyelin synthesis in BHK cells.
Topics: Animals; Biomarkers; Brefeldin A; Cell Fractionation; Cell Line; Cell Membrane; Centrifugation, Density Gradient; Ceramides; Cricetinae; Cyclopentanes; Digitonin; Endosomes; Glucosylceramides; Glucosyltransferases; Golgi Apparatus; Lipids; Proteins; Sphingomyelin Phosphodiesterase; Sphingomyelins; Subcellular Fractions; Transferases (Other Substituted Phosphate Groups) | 1997 |
The effects of brefeldin A (BFA) on cell cycle progression involving the modulation of the retinoblastoma protein (pRB) in PC-3 prostate cancer cells.
Topics: Brefeldin A; Cell Division; Cyclin-Dependent Kinases; Cyclopentanes; G1 Phase; Humans; Male; Phosphorylation; Prostatic Neoplasms; Protein Synthesis Inhibitors; Retinoblastoma Protein; S Phase; Time Factors; Tumor Cells, Cultured | 1998 |
Brefeldin A inhibits thrombin receptor regeneration in human endothelial cells.
Topics: Brefeldin A; Calcium; Cyclopentanes; Dose-Response Relationship, Drug; Endothelium, Vascular; Humans; Peptide Fragments; Receptors, Thrombin; Temperature; Umbilical Veins | 1997 |
Endothelium-derived hyperpolarizing factor, but not nitric oxide, is reversibly inhibited by brefeldin A.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Aorta; Biological Factors; Bradykinin; Brefeldin A; Cells, Cultured; Coronary Vessels; Cyclic GMP; Cyclopentanes; Drug Synergism; Endothelium, Vascular; Golgi Apparatus; Humans; In Vitro Techniques; Membrane Potentials; Muscle Contraction; Muscle, Smooth, Vascular; Nitric Oxide; Nitric Oxide Synthase; Nitroprusside; Rabbits; Swine; Umbilical Veins; Vasodilation | 1997 |
Soluble form of complement C3b/C4b receptor (CR1) results from a proteolytic cleavage in the C-terminal region of CR1 transmembrane domain.
Topics: Amino Acid Sequence; Animals; Brefeldin A; Cell Membrane; COS Cells; Cyclopentanes; Electrophoresis, Polyacrylamide Gel; Endopeptidases; Endoplasmic Reticulum; Glycosylation; Humans; Lysosomes; Molecular Sequence Data; Mutagenesis; Precipitin Tests; Protein Processing, Post-Translational; Receptors, Complement 3b; Recombinant Fusion Proteins; Solubility; Urokinase-Type Plasminogen Activator | 1998 |
Adhesion molecules are upregulated on dendritic cells isolated from human blood.
Topics: Brefeldin A; CD18 Antigens; Cell Adhesion Molecules; Cell Culture Techniques; Cycloheximide; Cyclopentanes; Dendritic Cells; Flow Cytometry; Humans; Integrin beta1; Protein Synthesis Inhibitors; Up-Regulation | 1997 |
Trafficking of wheat gluten proteins in transgenic tobacco plants: gamma-gliadin does not contain an endoplasmic reticulum-retention signal.
Topics: Brefeldin A; Cyclopentanes; Endoplasmic Reticulum; Gliadin; Nicotiana; Oligopeptides; Plants, Genetically Modified; Plants, Toxic; Protein Sorting Signals; Protein Synthesis Inhibitors; Recombinant Fusion Proteins; RNA, Messenger; Transgenes; Triticum | 1997 |
Processing of Mycobacterium tuberculosis bacilli by human monocytes for CD4+ alphabeta and gammadelta T cells: role of particulate antigen.
Topics: Ammonium Chloride; Antigen Presentation; Antigens, Bacterial; Brefeldin A; CD4-Positive T-Lymphocytes; Cell Division; Cells, Cultured; Chloroquine; Cyclopentanes; Cytochalasin D; Cytotoxicity Tests, Immunologic; Formaldehyde; HLA-DR Antigens; Humans; Monocytes; Mycobacterium tuberculosis; Phagocytosis; Receptors, Antigen, T-Cell, alpha-beta; Receptors, Antigen, T-Cell, gamma-delta | 1998 |
Surrogate antigen processing mediated by TAP-dependent antigenic peptide secretion.
Topics: Animals; ATP-Binding Cassette Transporters; Azides; Brefeldin A; Cells, Cultured; Chlorocebus aethiops; Cyclopentanes; Emetine; Endoplasmic Reticulum; Genetic Vectors; Histocompatibility Antigens Class I; Humans; L Cells; Mice; Mice, Inbred C57BL; Nucleocapsid; Nucleocapsid Proteins; Recombinant Fusion Proteins; Rhabdoviridae Infections; T-Lymphocytes, Cytotoxic; Transfection; Tumor Cells, Cultured; Vaccinia virus; Vero Cells; Vesicular stomatitis Indiana virus | 1998 |
Inhibitory effect of dideoxyforskolin on cell death induced by ricin, modeccin, diphtheria toxin, and Pseudomonas toxin in MDCK cells.
Topics: Animals; Apoptosis; Bacterial Toxins; Brefeldin A; Calcium; Cell Death; Cell Line; Colforsin; Cyclopentanes; Diphtheria; DNA Fragmentation; Dogs; Kidney; Lectins; Plant Lectins; Protein Biosynthesis; Protein Synthesis Inhibitors; Proteins; Pseudomonas; Ribosome Inactivating Proteins, Type 2; Ricin | 1997 |
Upregulation of SGLT-1 transport activity in rat jejunum induced by GLP-2 infusion in vivo.
Topics: Androstadienes; Animals; Brefeldin A; Cyclopentanes; Gastrointestinal Hormones; Glucagon-Like Peptide 2; Glucagon-Like Peptides; Glucose; Infusions, Intravenous; Intestinal Mucosa; Jejunum; Kinetics; Membrane Glycoproteins; Microvilli; Monosaccharide Transport Proteins; Peptides; Phlorhizin; Rats; Sodium; Sodium-Glucose Transporter 1; Wortmannin | 1997 |
Transport and turnover of microtubules in frog neurons depend on the pattern of axonal growth.
Topics: Animals; Axons; Brefeldin A; Carbocyanines; Cell Adhesion; Cell Culture Techniques; Cell Membrane; Cells, Cultured; Concanavalin A; Cyclopentanes; Fluorescent Dyes; Laminin; Microinjections; Microtubules; Neurons; Photochemistry; Protein Synthesis Inhibitors; Stress, Mechanical; Swine; Tubulin; Xenopus | 1998 |
Identification of tropoelastin as a ligand for the 65-kD FK506-binding protein, FKBP65, in the secretory pathway.
Topics: Amino Acid Isomerases; Animals; Brefeldin A; Carrier Proteins; Cattle; Cell Compartmentation; Centrifugation, Density Gradient; Cyclopentanes; Cysteine; DNA-Binding Proteins; Heat-Shock Proteins; Leupeptins; Ligands; Methionine; Molecular Weight; Protein Folding; Protein Synthesis Inhibitors; Tacrolimus; Tacrolimus Binding Proteins; Tropoelastin | 1998 |
Modulation of class I major histocompatibility complex antigen cell-surface stability by transmembrane domain length variation.
Topics: Amino Acid Sequence; Antigens, Surface; Brefeldin A; Cells, Cultured; Cyclopentanes; Flow Cytometry; Genes, MHC Class I; HLA-A2 Antigen; Humans; Molecular Sequence Data; Protein Synthesis Inhibitors; Radioimmunoassay; Time Factors; Transfection | 1997 |
Effect of long-term treatment of 3T3-L1 adipocytes with chlorate on the synthesis, glycosylation, intracellular transport and secretion of lipoprotein lipase.
Topics: 3T3 Cells; Adipocytes; Animals; Biological Transport, Active; Brefeldin A; Cell Membrane; Chlorates; Chromatography, Agarose; Culture Media; Cyclopentanes; DNA; Enzyme Activation; Glycosylation; Half-Life; Intracellular Fluid; Lipoprotein Lipase; Mice; Sulfur Radioisotopes; Triglycerides | 1998 |
Sulphation of N-linked oligosaccharides of vesicular stomatitis and influenza virus envelope glycoproteins: host cell specificity, subcellular localization and identification of substituted saccharides.
Topics: Animals; Antiviral Agents; Brefeldin A; Carbohydrate Conformation; Carbohydrate Sequence; Cattle; Cell Line; CHO Cells; Cricetinae; Cyclopentanes; Dogs; Hemagglutinin Glycoproteins, Influenza Virus; Membrane Glycoproteins; Mice; Oligosaccharides; Rats; Subcellular Fractions; Sulfates; Sulfotransferases; Swine; Tumor Cells, Cultured; Vesicular stomatitis Indiana virus; Viral Envelope Proteins | 1998 |
Syntaxin 10: a member of the syntaxin family localized to the trans-Golgi network.
Topics: Amino Acid Sequence; Androstadienes; Base Sequence; Blotting, Northern; Brefeldin A; Cloning, Molecular; Cyclopentanes; Databases as Topic; Enzyme Inhibitors; Fluorescent Antibody Technique; Golgi Apparatus; Humans; Membrane Proteins; Molecular Sequence Data; Pancreas; Protein Synthesis Inhibitors; Qa-SNARE Proteins; Recombinant Proteins; RNA, Messenger; Sequence Alignment; Sequence Analysis, DNA; SNARE Proteins; Vesicular Transport Proteins; Wortmannin | 1998 |
Involvement of ATP-dependent Pseudomonas exotoxin translocation from a late recycling compartment in lymphocyte intoxication procedure.
Topics: Adenosine Triphosphate; ADP Ribose Transferases; Animals; Bacterial Toxins; Biological Transport; Brefeldin A; Cell Line; Cyclopentanes; Cytosol; Endocytosis; Endosomes; Exotoxins; GTP-Binding Proteins; Humans; Hydrogen-Ion Concentration; Intracellular Membranes; Lymphocytes; Membrane Fusion; Mice; Point Mutation; Pseudomonas aeruginosa Exotoxin A; rab4 GTP-Binding Proteins; Temperature; Transferrin; Virulence Factors | 1998 |
A pore-forming toxin interacts with a GPI-anchored protein and causes vacuolation of the endoplasmic reticulum.
Topics: Animals; Bacterial Toxins; Biological Transport; Brefeldin A; Cell Line; Cell Membrane; Cell Membrane Permeability; Cell Survival; Coatomer Protein; Cricetinae; Cyclopentanes; Endopeptidases; Endoplasmic Reticulum; Glycosylphosphatidylinositols; Golgi Apparatus; Membrane Glycoproteins; Membrane Potentials; Membrane Proteins; Microscopy, Electron; Pore Forming Cytotoxic Proteins; Protein Processing, Post-Translational; Vacuoles; Viral Envelope Proteins | 1998 |
Colon carcinoma cells use different mechanisms to escape CD95-mediated apoptosis.
Topics: Antigens, Neoplasm; Apoptosis; Brefeldin A; Carcinoma; Cell Transformation, Neoplastic; Colonic Neoplasms; Cycloheximide; Cyclopentanes; Dactinomycin; Enzyme Inhibitors; Fas Ligand Protein; fas Receptor; Humans; Immunologic Capping; Interferon-gamma; Intestinal Mucosa; Membrane Glycoproteins; Nucleic Acid Synthesis Inhibitors; Phorbol Esters; Protein Kinase C; Protein Synthesis Inhibitors; Signal Transduction; Staurosporine; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1998 |
Evidence for a cholesterol transport pathway from lysosomes to endoplasmic reticulum that is independent of the plasma membrane.
Topics: Amphotericin B; Androstenes; Animals; Biological Transport; Brefeldin A; Cell Membrane; CHO Cells; Cholesterol Esters; Cholesterol Oxidase; Cholesterol, LDL; Cricetinae; Cyclopentanes; Endoplasmic Reticulum; Enzyme Inhibitors; Imipramine; Lipoproteins, LDL; Lysosomes; Microscopy, Fluorescence; Oleic Acid; Sphingomyelin Phosphodiesterase; Sterol O-Acyltransferase | 1998 |
Brefeldin A affects synthesis and integrity of a eukaryotic flagellum.
Topics: Brefeldin A; Cyclopentanes; Eukaryota; Flagella; Golgi Apparatus; Hydrogen-Ion Concentration; Kinetics; Protein Synthesis Inhibitors; Regeneration | 1998 |
Molecular cloning and localization of human syntaxin 16, a member of the syntaxin family of SNARE proteins.
Topics: Amino Acid Sequence; Base Sequence; Blotting, Northern; Brefeldin A; Cloning, Molecular; Cyclopentanes; Fluorescent Antibody Technique; Gene Expression; Golgi Apparatus; Humans; Membrane Proteins; Microscopy, Fluorescence; Molecular Sequence Data; Nerve Tissue Proteins; Qa-SNARE Proteins; RNA, Messenger; Sequence Alignment; Sequence Analysis, DNA; SNARE Proteins; Syntaxin 16; Vesicular Transport Proteins | 1998 |
RANTES activation of phospholipase D in Jurkat T cells: requirement of GTP-binding proteins ARF and RhoA.
Topics: ADP-Ribosylation Factors; Amino Acid Sequence; Brefeldin A; Chemokine CCL5; Cyclopentanes; Drug Synergism; Enzyme Activation; Epoxy Compounds; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Jurkat Cells; Molecular Sequence Data; Phospholipase D; Protein Binding; Protein Kinase C; rhoA GTP-Binding Protein; Spiro Compounds; T-Lymphocytes | 1998 |
Over-expression of the yeast BFR2 gene partially suppresses the growth defects induced by Brefeldin A and by four ER-to-Golgi mutations.
Topics: Antifungal Agents; Brefeldin A; Cyclopentanes; Endoplasmic Reticulum; Gene Expression Regulation, Fungal; Genes, Fungal; Genes, Suppressor; Golgi Apparatus; Mutation; Nystatin; Organelles; Receptors, Fibroblast Growth Factor; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins | 1998 |
Reduced expression of the macrophage scavenger receptors in macrophage-like cell mutants resistant to brefeldin A.
Topics: Animals; Base Sequence; Brefeldin A; Cell Line; Cholesterol; Cholesterol Esters; Clone Cells; Colony-Forming Units Assay; Cyclopentanes; DNA Primers; Drug Resistance; Foam Cells; Gene Expression; Lipoproteins, LDL; Macrophages; Mice; Mutation; Receptors, Immunologic; Receptors, Scavenger; RNA, Messenger | 1998 |
The microsomal triglyceride transfer protein catalyzes the post-translational assembly of apolipoprotein B-100 very low density lipoprotein in McA-RH7777 cells.
Topics: Animals; Apolipoprotein B-100; Apolipoproteins B; Brefeldin A; Carrier Proteins; Cell Fractionation; Centrifugation, Density Gradient; Cycloheximide; Cyclopentanes; Lipoproteins, VLDL; Membrane Proteins; Microsomes; Protein Processing, Post-Translational; Protein Synthesis Inhibitors; Rats; Tumor Cells, Cultured | 1998 |
SNAP-25 palmitoylation and plasma membrane targeting require a functional secretory pathway.
Topics: Acylation; Animals; Biological Transport, Active; Brefeldin A; Cell Line; Cell Membrane; Cyclopentanes; GAP-43 Protein; GTP-Binding Proteins; Kinetics; Membrane Proteins; Nerve Tissue Proteins; Neurotransmitter Agents; Palmitic Acids; PC12 Cells; Presynaptic Terminals; Protein Conformation; Protein Processing, Post-Translational; Protein Synthesis Inhibitors; Rats; Subcellular Fractions; Synaptosomal-Associated Protein 25 | 1998 |
An apical-type trafficking pathway is present in cultured oligodendrocytes but the sphingolipid-enriched myelin membrane is the target of a basolateral-type pathway.
Topics: Animals; Anti-Bacterial Agents; Biological Transport, Active; Brefeldin A; Cell Membrane; Cell Polarity; Cells, Cultured; Cyclopentanes; Golgi Apparatus; Hemagglutinin Glycoproteins, Influenza Virus; Immunohistochemistry; Macrolides; Membrane Glycoproteins; Myelin Sheath; Oligodendroglia; Rats; Solubility; Sphingolipids; Vesicular stomatitis Indiana virus; Viral Envelope Proteins | 1998 |
Inhibition of phosphorylation of the oxysterol binding protein by brefeldin A.
Topics: Animals; Brefeldin A; CHO Cells; Cricetinae; Cyclopentanes; Electrophoresis, Polyacrylamide Gel; Enzyme Inhibitors; Fluorescent Antibody Technique, Indirect; Golgi Apparatus; Hydroxycholesterols; Molecular Weight; Okadaic Acid; Phosphorylation; Protein Kinases; Protein Synthesis Inhibitors; Rabbits; Rats; Receptors, Steroid; Serine; Staurosporine | 1998 |
Intracellular trafficking of metallocarboxypeptidase D in AtT-20 cells: localization to the trans-Golgi network and recycling from the cell surface.
Topics: Animals; Anti-Bacterial Agents; Brefeldin A; Carboxypeptidases; Cell Line; Cell Membrane; Cyclopentanes; Golgi Apparatus; Hepatitis B Virus, Duck; Intracellular Fluid; Macrolides; Membrane Glycoproteins; Mice; Pituitary Gland, Anterior; Protein Processing, Post-Translational; Proteins; Receptors, Virus | 1998 |
Role of an acidic compartment in tumor-necrosis-factor-alpha-induced production of ceramide, activation of caspase-3 and apoptosis.
Topics: Ammonium Chloride; Animals; Apoptosis; Brefeldin A; Caspase 3; Caspases; Cell Compartmentation; Cyclopentanes; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Endosomes; Enzyme Activation; Humans; Lysosomes; Mice; Oligopeptides; Poly(ADP-ribose) Polymerases; Proto-Oncogene Proteins c-bcl-2; Signal Transduction; Sphingomyelin Phosphodiesterase; Sphingosine; Tumor Necrosis Factor-alpha | 1998 |
Interconversion of sphingomyelin and ceramide in adult Schistosoma mansoni.
Topics: Ammonium Chloride; Animals; Boron Compounds; Brefeldin A; Ceramides; Cyclopentanes; Desipramine; Fluorescent Dyes; Lysosomes; Male; Monensin; Perhexiline; Schistosoma mansoni; Sphingomyelins | 1997 |
Transport of cholesterol from the endoplasmic reticulum to the plasma membrane is constitutive in CaCo-2 cells and differs from the transport of plasma membrane cholesterol to the endoplasmic reticulum.
Topics: ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Brefeldin A; Caco-2 Cells; Cell Membrane; Cholesterol; Colchicine; Cycloheximide; Cyclopentanes; Digitonin; Endoplasmic Reticulum; Filipin; Golgi Apparatus; Humans; Kinetics; Microtubules; Monensin; Protein Synthesis Inhibitors | 1998 |
Multidrug resistance phenotype conferred by overexpressing bfr2+/pad1+/sks1+ or pap1+ genes and mediated by bfr1+ gene product, a structural and functional homologue of P-glycoprotein in Schizosaccharomyces pombe.
Topics: Anti-Bacterial Agents; Antifungal Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Brefeldin A; Carbazoles; Cyclopentanes; Cytochalasin B; Dactinomycin; Drug Resistance, Multiple; Drug Synergism; Enzyme Inhibitors; Fungal Proteins; Gene Expression Regulation, Fungal; Indole Alkaloids; Macrolides; Mycotoxins; Pancreatitis-Associated Proteins; Phenotype; Protein Kinase C; Protein Synthesis Inhibitors; Repressor Proteins; Saccharomyces cerevisiae Proteins; Schizosaccharomyces; Sequence Analysis, DNA; Staurosporine | 1998 |
Blockade of the classical pathway of protein secretion does not affect the cellular exportation of lipocortin 1.
Topics: Animals; Annexin A1; Biological Transport; Brain; Brefeldin A; Cyclopentanes; Dexamethasone; Macrophages, Peritoneal; Male; Monensin; Nocodazole; Pituitary Gland, Anterior; Rats; Rats, Sprague-Dawley | 1998 |
Rhodopsin-family receptors associate with small G proteins to activate phospholipase D.
Topics: ADP-Ribosylation Factors; Animals; Brefeldin A; COS Cells; Cyclopentanes; Enzyme Activation; Estrenes; GTP-Binding Proteins; Guanosine Triphosphate; Humans; Male; Phospholipase D; Pyrrolidinones; Rats; Receptor, Muscarinic M3; Receptors, LHRH; Receptors, Muscarinic; Recombinant Proteins; rhoA GTP-Binding Protein; Rhodopsin; Tumor Cells, Cultured; Type C Phospholipases | 1998 |
Brefeldin A-inhibited guanine nucleotide-exchange activity of Sec7 domain from yeast Sec7 with yeast and mammalian ADP ribosylation factors.
Topics: ADP-Ribosylation Factor 1; ADP-Ribosylation Factors; Brefeldin A; Carrier Proteins; Cholera Toxin; Cloning, Molecular; Cyclopentanes; DNA Primers; Fungal Proteins; GTP-Binding Proteins; Guanine Nucleotide Exchange Factors; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Kinetics; NAD; Polymerase Chain Reaction; Recombinant Proteins; Saccharomyces cerevisiae; Sequence Tagged Sites | 1998 |
Ubiquitination is required for the retro-translocation of a short-lived luminal endoplasmic reticulum glycoprotein to the cytosol for degradation by the proteasome.
Topics: Animals; Brefeldin A; Calcium-Binding Proteins; Calnexin; Cell Line; Cricetinae; Cyclopentanes; Cysteine Endopeptidases; Cytosol; Endoplasmic Reticulum; Intracellular Membranes; Kinetics; Ligases; Membrane Glycoproteins; Membrane Proteins; Microsomes; Multienzyme Complexes; Mutagenesis; Proteasome Endopeptidase Complex; Protein Synthesis Inhibitors; Recombinant Proteins; Sequence Deletion; Temperature; Ubiquitin-Activating Enzymes; Ubiquitin-Protein Ligases; Ubiquitins | 1998 |
The distribution and translocation of the G protein ADP-ribosylation factor 1 in live cells is determined by its GTPase activity.
Topics: ADP-Ribosylation Factor 1; ADP-Ribosylation Factors; Animals; Anti-Bacterial Agents; Biological Transport; Brefeldin A; Cyclopentanes; Cytosol; Fibroblasts; Fluorometry; Golgi Apparatus; Green Fluorescent Proteins; GTP Phosphohydrolases; GTP-Binding Proteins; Guanosine Triphosphate; Humans; Luminescent Proteins; Macrolides; Photochemistry; Rats; Recombinant Fusion Proteins; Structure-Activity Relationship | 1998 |
Tubular peroxisomes in HepG2 cells: selective induction by growth factors and arachidonic acid.
Topics: 3T3 Cells; 5,8,11,14-Eicosatetraynoic Acid; Animals; Arachidonic Acid; ATP-Binding Cassette Transporters; Bezafibrate; Brefeldin A; Culture Media; Cyclopentanes; Fatty Acids, Unsaturated; Gene Expression; Growth Substances; Humans; Lipid Metabolism; Membrane Proteins; Mice; Microbodies; Microtubules; Nerve Growth Factors; PC12 Cells; Protein Kinase C; Proteins; Proto-Oncogene Proteins; Rats; Receptor Protein-Tyrosine Kinases; Receptor, Ciliary Neurotrophic Factor; Receptor, trkA; Receptor, trkC; Receptors, Nerve Growth Factor; RNA, Messenger; Serum Albumin, Bovine; Signal Transduction; Tumor Cells, Cultured | 1998 |
Two types of virus-related particles are found during transmissible gastroenteritis virus morphogenesis.
Topics: Animals; Antimetabolites; Brefeldin A; Cell Line; Cyclopentanes; Morphogenesis; Nocodazole; Swine; Transmissible gastroenteritis virus; Virion; Virus Assembly | 1998 |
In polarized MDCK cells basolateral vesicles arise from clathrin-gamma-adaptin-coated domains on endosomal tubules.
Topics: Adaptor Protein Complex gamma Subunits; Animals; Arabidopsis Proteins; Biological Transport; Brefeldin A; Carrier Proteins; Cell Compartmentation; Cell Differentiation; Cell Line; Cell Membrane; Cell Polarity; Clathrin; Cyclopentanes; Dogs; Endosomes; Golgi Apparatus; Humans; Membrane Proteins; Organelles; Plant Proteins; Protein Synthesis Inhibitors; Receptors, Polymeric Immunoglobulin; Receptors, Transferrin; Ubiquitin-Protein Ligases | 1998 |
Analysis of the processing of Plasmodium falciparum rhoptry-associated protein 1 and localization of Pr86 to schizont rhoptries and p67 to free merozoites.
Topics: Animals; Anti-Bacterial Agents; Antibodies, Protozoan; Antigens, Protozoan; Brefeldin A; Cell Compartmentation; Cell Differentiation; Cyclopentanes; Epitopes; Macrolides; Organelles; Plasmodium falciparum; Protein Binding; Protein Processing, Post-Translational; Protein Synthesis Inhibitors; Protozoan Proteins | 1998 |
Porcine submaxillary mucin forms disulfide-linked multimers through its amino-terminal D-domains.
Topics: Animals; Anti-Bacterial Agents; Brefeldin A; Chloroquine; COS Cells; Cyclopentanes; Disulfides; Glycosylation; Golgi Apparatus; Hydrogen-Ion Concentration; Macrolides; Molecular Sequence Data; Monensin; Mucins; Protein Conformation; Proton-Translocating ATPases; Recombinant Proteins; Submandibular Gland; Swine; Transfection | 1998 |
Notch-1 signalling requires ligand-induced proteolytic release of intracellular domain.
Topics: 3T3 Cells; Amino Acid Sequence; Animals; Basic Helix-Loop-Helix Transcription Factors; Brefeldin A; Cell Line; Cell Nucleus; Cyclopentanes; DNA-Binding Proteins; Gene Expression Regulation; Genes, Reporter; Golgi Apparatus; Homeodomain Proteins; Ligands; Membrane Proteins; Mice; Molecular Sequence Data; Monensin; Mutagenesis; Peptide Fragments; Promoter Regions, Genetic; Protein Processing, Post-Translational; Receptor, Notch1; Receptors, Cell Surface; Signal Transduction; Transcription Factor HES-1; Transcription Factors; Transfection | 1998 |
Cytometric study of intracellular P-gp expression and reversal of drug resistance.
Topics: Anti-Bacterial Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Base Sequence; Brefeldin A; Cell Division; Cycloheximide; Cyclopentanes; Cytoplasm; DNA Primers; Drug Resistance, Multiple; Flow Cytometry; Fluorescent Antibody Technique; Gene Expression Regulation, Neoplastic; HL-60 Cells; Humans; Kinetics; Leukemia; Macrolides; Oligodeoxyribonucleotides; Polymerase Chain Reaction; Protein Synthesis Inhibitors; Proto-Oncogene Proteins c-abl; RNA, Messenger; Transfection; Tumor Cells, Cultured | 1998 |
The protozoan parasite Toxoplasma gondii targets proteins to dense granules and the vacuolar space using both conserved and unusual mechanisms.
Topics: Alkaline Phosphatase; Amino Acid Sequence; Animals; Anti-Bacterial Agents; beta-Lactamases; Binding Sites; Brefeldin A; Cell Membrane; Chlorocebus aethiops; Cyclopentanes; Cytoplasm; Escherichia coli; Fluorescent Antibody Technique, Indirect; Gene Expression; Glycosylphosphatidylinositols; Golgi Apparatus; Macrolides; Membrane Glycoproteins; Mice; Microscopy, Immunoelectron; Molecular Sequence Data; Protein Synthesis Inhibitors; Protozoan Proteins; Subcellular Fractions; Toxoplasma; Vacuoles; Vero Cells; Viral Envelope Proteins | 1998 |
pH-sensitive, cationic liposomes: a new synthetic virus-like vector.
Topics: 3T3 Cells; Animals; Anti-Bacterial Agents; Brefeldin A; Cations; Chloroquine; Cyclopentanes; Endosomes; Genetic Vectors; Hydrogen-Ion Concentration; Liposomes; Macrolides; Mice; Transfection | 1996 |
Activation of phospholipase D by ADP-ribosylation factor in rat submandibular acinar cells.
Topics: Animals; Anti-Bacterial Agents; Arachidonic Acids; Brefeldin A; Carbachol; Carrier Proteins; Cyclopentanes; Cytosol; Diglycerides; Dose-Response Relationship, Drug; Enzyme Activation; Estrenes; GTP-Binding Proteins; Guanine Nucleotides; Guanosine 5'-O-(3-Thiotriphosphate); Hydrolysis; Macrolides; Male; Membrane Lipids; Phosphatidic Acids; Phosphatidylcholines; Phosphodiesterase Inhibitors; Phospholipase D; Poly(ADP-ribose) Polymerases; Protein Synthesis Inhibitors; Pyrrolidinones; ras Proteins; Rats; Rats, Sprague-Dawley; Signal Transduction; Submandibular Gland; Time Factors; Type C Phospholipases | 1998 |
Brefeldin A (BFA) inhibits basolateral membrane (BLM) delivery and dimerization of transcobalamin II receptor in human intestinal epithelial Caco-2 cells. BFA effects on BLM cholesterol content.
Topics: Anti-Bacterial Agents; Basement Membrane; Brefeldin A; Caco-2 Cells; Cholesterol; Cyclopentanes; Dimerization; Humans; Intestinal Mucosa; Lipid Bilayers; Macrolides; Microscopy, Confocal; Microscopy, Fluorescence; Molecular Weight; N-Acetylneuraminic Acid; Oligosaccharides; Receptors, Cell Surface | 1998 |
Microtubules and intracellular traffic of secretory proteins in rat extraorbital lacrimal glands.
Topics: Animals; Anti-Bacterial Agents; Brefeldin A; Carbon Radioisotopes; Cyclopentanes; Docetaxel; Eye Proteins; Galactose; Glycoproteins; Golgi Apparatus; In Vitro Techniques; Kinetics; Lacrimal Apparatus; Leucine; Macrolides; Male; Microtubules; Nocodazole; Paclitaxel; Rats; Rats, Sprague-Dawley; Taxoids; Time Factors; Tritium | 1998 |
Brefeldin A detoxification in rat extraorbital lacrimal glands.
Topics: Animals; Anti-Bacterial Agents; Brefeldin A; Cyclopentanes; Cysteine; Eye Proteins; Glutathione; In Vitro Techniques; Inactivation, Metabolic; Isoproterenol; Lacrimal Apparatus; Leucine; Macrolides; Male; Rats; Rats, Sprague-Dawley | 1998 |
Roles of secretion and the cytoskeleton in cell adhesion and polarity establishment in Pelvetia compressa zygotes.
Topics: Actins; Anti-Bacterial Agents; Bodily Secretions; Brefeldin A; Bridged Bicyclo Compounds, Heterocyclic; Cell Adhesion; Cyclopentanes; Cytochalasin D; Cytoskeleton; Dinitrobenzenes; Eukaryota; Light; Macrolides; Microscopy, Confocal; Monensin; Sulfanilamides; Thiazoles; Thiazolidines; Zygote | 1998 |
Expression of the yeast BFR2 gene is regulated at the transcriptional level and through degradation of its product.
Topics: Anti-Bacterial Agents; Antifungal Agents; Brefeldin A; Cell Division; Cyclopentanes; Fungal Proteins; Gene Expression Regulation, Fungal; Glucose; Golgi Apparatus; Macrolides; Oxidative Stress; RNA, Messenger; Saccharomyces cerevisiae; Suppression, Genetic | 1998 |
Characterization of a voltage-dependent conductance in the basolateral membrane of leech skin epithelium.
Topics: Amiloride; Animals; Anti-Bacterial Agents; Brefeldin A; Calcium; Cell Membrane; Cyclopentanes; Cytochalasins; Electric Conductivity; Epithelial Cells; Ion Channels; Leeches; Nystatin; Osmolar Concentration; Patch-Clamp Techniques; Skin Physiological Phenomena; Sodium Channels | 1998 |
The pleckstrin homology domain of oxysterol-binding protein recognises a determinant specific to Golgi membranes.
Topics: Animals; Anti-Bacterial Agents; Blood Proteins; Brefeldin A; Conserved Sequence; Cyclopentanes; Evolution, Molecular; Exocytosis; Golgi Apparatus; Intracellular Membranes; Liposomes; Macrolides; Mycotoxins; Phosphoproteins; Protein Structure, Tertiary; Rats; Receptors, Steroid; Sequence Homology, Amino Acid; Substrate Specificity | 1998 |
Targeted disruption of mouse conventional kinesin heavy chain, kif5B, results in abnormal perinuclear clustering of mitochondria.
Topics: Animals; Anti-Bacterial Agents; Brefeldin A; Cell Fractionation; Cell Nucleus; Cells, Cultured; Cyclopentanes; Gene Expression Regulation, Developmental; Genes, Lethal; Golgi Apparatus; Kinesins; Lysosomes; Macrolides; Mice; Mice, Knockout; Microtubules; Mitochondria; Nocodazole; Phenotype; RNA, Messenger; Yolk Sac | 1998 |
Brefeldin A inhibits cell-free, de novo synthesis of poliovirus.
Topics: ADP-Ribosylation Factors; Animals; Anti-Bacterial Agents; Antiviral Agents; Binding, Competitive; Brefeldin A; Cell-Free System; Cyclopentanes; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); HeLa Cells; Humans; Macrolides; Mice; Poliovirus; Virus Replication | 1998 |
PDMP blocks brefeldin A-induced retrograde membrane transport from golgi to ER: evidence for involvement of calcium homeostasis and dissociation from sphingolipid metabolism.
Topics: Animals; Anti-Bacterial Agents; Biological Transport, Active; Brefeldin A; Calcium; Cell Line; Ceramides; Cyclopentanes; Endoplasmic Reticulum; Glucosylceramides; Golgi Apparatus; Homeostasis; HT29 Cells; Humans; Intracellular Membranes; Lipid Metabolism; Macrolides; Morpholines; Propionates; Quinolines; Rats; Sphingolipids; Sphingomyelins | 1998 |
Removal and degradation of the free MHC class II beta chain in the endoplasmic reticulum requires proteasomes and is accelerated by BFA.
Topics: Acetylcysteine; Anti-Bacterial Agents; Brefeldin A; Cell Fractionation; Cell Line; Cyclopentanes; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Endoplasmic Reticulum; Golgi Apparatus; Histocompatibility Antigens Class II; HLA-B27 Antigen; Humans; Kidney; Macrolides; Multienzyme Complexes; Proteasome Endopeptidase Complex; Protein Synthesis Inhibitors; Recombinant Fusion Proteins | 1998 |
NK cells can recognize different forms of class I MHC.
Topics: Amino Acid Sequence; Animals; Anti-Bacterial Agents; Antigens, Ly; Antigens, Surface; Brefeldin A; Concanavalin A; Cyclopentanes; Cytotoxicity Tests, Immunologic; Cytotoxicity, Immunologic; H-2 Antigens; Histocompatibility Antigens Class I; Killer Cells, Natural; Lectins, C-Type; Lymphocyte Activation; Macrolides; Membrane Glycoproteins; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Knockout; Mice, Nude; Molecular Sequence Data; Peptide Fragments; Protein Binding; Protein Synthesis Inhibitors; Receptors, Immunologic; Receptors, KIR; Receptors, NK Cell Lectin-Like; T-Lymphocytes, Cytotoxic; Time Factors | 1998 |
Evidence that phospholipase A2 activity is required for Golgi complex and trans Golgi network membrane tubulation.
Topics: Animals; Anti-Bacterial Agents; Brefeldin A; Clone Cells; Cyclopentanes; Enzyme Inhibitors; Fluorescent Antibody Technique; Golgi Apparatus; Intracellular Membranes; Macrolides; Phospholipases A; Phospholipases A2; Rats | 1998 |
Effect of inhibitors of the intracellular exocytic pathway on glycoprotein processing and maturation of Junin virus.
Topics: Animals; Anti-Bacterial Agents; Antiviral Agents; Brefeldin A; Carbonyl Cyanide m-Chlorophenyl Hydrazone; Chlorocebus aethiops; Cyclopentanes; Endopeptidases; Exocytosis; Glycoproteins; Junin virus; Macrolides; Protein Processing, Post-Translational; Protein Synthesis Inhibitors; Rabbits; Subcellular Fractions; Vero Cells; Viral Envelope Proteins | 1997 |
Phospholipid composition of purified Chlamydia trachomatis mimics that of the eucaryotic host cell.
Topics: Animals; Anti-Bacterial Agents; Antimetabolites; Brefeldin A; Carboxylic Acids; Cell Line; Chlamydia trachomatis; CHO Cells; Cricetinae; Cyclopentanes; Eukaryotic Cells; Fumonisins; HeLa Cells; Humans; Macrolides; Mice; Phospholipids; Sphingomyelin Phosphodiesterase; Sphingomyelins | 1998 |
Localization of Tctex-1, a cytoplasmic dynein light chain, to the Golgi apparatus and evidence for dynein complex heterogeneity.
Topics: Amino Acid Sequence; Animals; Anti-Bacterial Agents; Base Sequence; Brefeldin A; Cattle; Cells, Cultured; Cloning, Molecular; Cyclopentanes; Cytochalasin D; Dynactin Complex; Dyneins; Golgi Apparatus; Immunohistochemistry; Intracellular Signaling Peptides and Proteins; Macrolides; Microtubule-Associated Proteins; Molecular Sequence Data; Nocodazole; Nuclear Proteins; Precipitin Tests; Sequence Analysis, DNA; Sequence Homology, Amino Acid; Spindle Apparatus; t-Complex Genome Region; Ubiquitin-Protein Ligases | 1998 |
ADP-Ribosylation factor 1 (ARF1) regulates recruitment of the AP-3 adaptor complex to membranes.
Topics: Adaptor Proteins, Vesicular Transport; ADP-Ribosylation Factor 1; ADP-Ribosylation Factors; Animals; Anti-Bacterial Agents; Brain; Brefeldin A; Cattle; Cells, Cultured; Cyclopentanes; Cytosol; Dogs; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Triphosphate; HeLa Cells; Humans; In Vitro Techniques; Intracellular Membranes; Macrolides; Microscopy, Fluorescence; Monomeric Clathrin Assembly Proteins; Mutation; Nerve Tissue Proteins; Phosphoproteins; Recombinant Proteins; Signal Transduction | 1998 |
Prevention of brefeldin A-induced resistance to teniposide by the proteasome inhibitor MG-132: involvement of NF-kappaB activation in drug resistance.
Topics: Animals; Anti-Bacterial Agents; Antineoplastic Agents, Phytogenic; Brefeldin A; Carrier Proteins; Cyclopentanes; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Drug Resistance, Neoplasm; Endoplasmic Reticulum Chaperone BiP; Heat-Shock Proteins; Leupeptins; Macrolides; Mice; Molecular Chaperones; Multienzyme Complexes; Neoplasm Proteins; NF-kappa B; Proteasome Endopeptidase Complex; Protein Synthesis Inhibitors; Teniposide; Tumor Cells, Cultured | 1998 |
Secretion of plasminogen activator inhibitor 2 by human peripheral blood monocytes occurs via an endoplasmic reticulum-golgi-independent pathway.
Topics: Anti-Bacterial Agents; Antiviral Agents; Brefeldin A; Cells, Cultured; Culture Media, Conditioned; Cyclopentanes; Endoplasmic Reticulum; Fluorescent Antibody Technique, Direct; Golgi Apparatus; Humans; Macrolides; Microscopy, Confocal; Monocytes; Plasminogen Activator Inhibitor 2; Tumor Cells, Cultured; Tunicamycin | 1998 |
A requirement for ARF6 in Fcgamma receptor-mediated phagocytosis in macrophages.
Topics: Actins; ADP-Ribosylation Factors; Animals; Anti-Bacterial Agents; Boron Compounds; Brefeldin A; Cell Line; Ceramides; Coatomer Protein; Cyclopentanes; Cytoskeleton; Erythrocytes; Fluorescent Dyes; Golgi Apparatus; GTP-Binding Proteins; Guanosine Triphosphate; Macrolides; Macrophages; Mice; Microscopy, Fluorescence; Microtubule-Associated Proteins; Receptors, IgG; Transfection | 1998 |
Characterization of KIF1C, a new kinesin-like protein involved in vesicle transport from the Golgi apparatus to the endoplasmic reticulum.
Topics: Amino Acid Sequence; Animals; Anti-Bacterial Agents; Brefeldin A; Cells, Cultured; Cloning, Molecular; Cyclopentanes; Endoplasmic Reticulum; Fluorescent Antibody Technique; Golgi Apparatus; Humans; Kinesins; Macrolides; Mice; Microtubules; Molecular Sequence Data; Phosphorylation; Phosphotyrosine; Protein Tyrosine Phosphatases; Rats; RNA, Messenger; Sequence Analysis, DNA; Sequence Homology, Amino Acid | 1998 |
On the role of the proform-conformation for processing and intracellular sorting of human cathepsin G.
Topics: Animals; Anti-Bacterial Agents; Aprotinin; Binding Sites; Biological Transport; Brefeldin A; Cathepsin G; Cathepsins; COS Cells; Cyclopentanes; Cytoplasmic Granules; DNA, Complementary; Enzyme Precursors; Glycosylation; Golgi Apparatus; Hematopoietic Stem Cells; Hexosaminidases; Humans; Leukemia, Basophilic, Acute; Macrolides; Mice; Mutagenesis, Site-Directed; Protein Conformation; Protein Folding; Protein Processing, Post-Translational; Rats; Recombinant Fusion Proteins; Sequence Deletion; Serine Endopeptidases; Substrate Specificity; Transfection; Tumor Cells, Cultured | 1998 |
Proparathyroid hormone-related protein is associated with the chaperone protein BiP and undergoes proteasome-mediated degradation.
Topics: Acetylcysteine; Animals; Anti-Bacterial Agents; Brefeldin A; Carrier Proteins; Cell Line; Cricetinae; Cricetulus; Cyclopentanes; Cysteine Endopeptidases; Cytoplasm; Endoplasmic Reticulum; Endoplasmic Reticulum Chaperone BiP; Heat-Shock Proteins; Hydrolysis; Macrolides; Molecular Chaperones; Multienzyme Complexes; Parathyroid Hormone-Related Protein; Proteasome Endopeptidase Complex; Protein Binding; Protein Precursors; Proteins; Subcellular Fractions | 1998 |
At the onset of transformation polyomavirus middle-T recruits shc and src to a perinuclear compartment coincident with condensation of endosomes.
Topics: Adaptor Proteins, Signal Transducing; Adaptor Proteins, Vesicular Transport; Adenoviruses, Human; Animals; Anti-Bacterial Agents; Antigens, Polyomavirus Transforming; Brefeldin A; Cell Compartmentation; Cell Line; Cell Line, Transformed; Cell Nucleus; Cell Transformation, Viral; Cyclopentanes; Endosomes; Genetic Vectors; Humans; Macrolides; Protein Synthesis Inhibitors; Proteins; Rats; Shc Signaling Adaptor Proteins; Src Homology 2 Domain-Containing, Transforming Protein 1; src Homology Domains | 1998 |
Binding and transcytosis of botulinum neurotoxin by polarized human colon carcinoma cells.
Topics: Animals; Anti-Bacterial Agents; Biological Transport; Botulinum Toxins; Botulinum Toxins, Type A; Brefeldin A; Caco-2 Cells; Cell Polarity; Colonic Neoplasms; Cyclopentanes; Digestive System; Dogs; Epithelial Cells; Humans; Macrolides; Methylamines; Mice; Nocodazole; Protein Binding; Temperature; Tetanus Toxin | 1998 |
Analysis of rab10 localization in sea urchin embryonic cells by three-dimensional reconstruction.
Topics: Amino Acid Sequence; Animals; Anti-Bacterial Agents; Antibodies; Brefeldin A; Cloning, Molecular; Conserved Sequence; Cyclopentanes; Fluorescent Antibody Technique, Indirect; Golgi Apparatus; GTP-Binding Proteins; Image Processing, Computer-Assisted; Macrolides; Molecular Sequence Data; rab GTP-Binding Proteins; Sea Urchins; Sequence Homology, Amino Acid | 1998 |
In vitro and in vivo studies on transthyretin oligomerization.
Topics: Animals; Anti-Bacterial Agents; Biopolymers; Brefeldin A; Cells, Cultured; COS Cells; Cyclopentanes; Dogs; Hepatoblastoma; Humans; In Vitro Techniques; Macrolides; Microsomes, Liver; Mutation; Pancreas; Prealbumin; Rats | 1998 |
Design and synthesis of brefeldin A sulfide derivatives as prodrug candidates with enhanced aqueous solubilities.
Topics: Animals; Anti-Bacterial Agents; Antibiotics, Antineoplastic; Brefeldin A; Cell Division; Cyclopentanes; Drug Design; Drug Screening Assays, Antitumor; Humans; Macrolides; Mice; Neoplasm Transplantation; Prodrugs; Solubility; Structure-Activity Relationship; Sulfides; Sulfones; Sulfoxides; Tumor Cells, Cultured | 1998 |
Membrane targeting of L-type calcium channels. Role of palmitoylation in the subcellular localization of the beta2a subunit.
Topics: Amino Acid Sequence; Animals; Anti-Bacterial Agents; Biological Transport; Brefeldin A; Calcium Channels; Calcium Channels, L-Type; Cell Compartmentation; Cyclopentanes; Cysteine; Macrolides; Molecular Sequence Data; Mutation; Palmitic Acid; Protein Processing, Post-Translational; Protein Synthesis Inhibitors; Rabbits; Rats; Recombinant Fusion Proteins; Species Specificity; src Homology Domains | 1998 |
The effects of brefeldin A on acrosome formation and protein transport to the acrosome in organ cultures of rat seminiferous tubules.
Topics: Acrosome; Animals; Anti-Bacterial Agents; Biological Transport; Brefeldin A; Cyclopentanes; Endoplasmic Reticulum; Golgi Apparatus; Macrolides; Male; Microscopy, Electron; Microscopy, Immunoelectron; Organ Culture Techniques; Proteins; Rats; Rats, Wistar; Seminiferous Tubules; Spermatids | 1998 |
Short-term and long-term cytokine release by mouse bone marrow mast cells and the differentiated KU-812 cell line are inhibited by brefeldin A.
Topics: Animals; Anti-Bacterial Agents; Basophils; Bone Marrow Cells; Brefeldin A; Cell Degranulation; Cell Differentiation; Cell Line; Cyclopentanes; Cytokines; Cytoplasmic Granules; Granulocyte-Macrophage Colony-Stimulating Factor; Growth Inhibitors; Humans; Interleukin-6; Macrolides; Male; Mast Cells; Mice; Mice, Inbred C57BL; Monensin; Protein Synthesis Inhibitors; RNA, Messenger; Time Factors | 1998 |
The cytoplasmic tail of rhodopsin acts as a novel apical sorting signal in polarized MDCK cells.
Topics: Animals; Anti-Bacterial Agents; Brefeldin A; Cell Line; Cell Membrane; Cyclopentanes; Dogs; Fluorescent Antibody Technique; Glycosylphosphatidylinositols; Golgi Apparatus; Macrolides; Membrane Proteins; Recombinant Fusion Proteins; Rhodopsin; Sequence Deletion; Signal Transduction; Transfection | 1998 |
Cytokine-stimulated release of decay-accelerating factor (DAF;CD55) from HT-29 human intestinal epithelial cells.
Topics: Anti-Bacterial Agents; Brefeldin A; CD55 Antigens; Cycloheximide; Cyclopentanes; Cytokines; Dactinomycin; HT29 Cells; Humans; Interleukin-1; Interleukin-4; Macrolides | 1998 |
Flow cytometric single-cell analysis of cytokine production by CD4+ T cells in synovial tissue and peripheral blood from patients with rheumatoid arthritis.
Topics: Aged; Aged, 80 and over; Anti-Bacterial Agents; Antigens, Surface; Arthritis, Rheumatoid; Brefeldin A; Calcimycin; CD28 Antigens; CD3 Complex; CD4-Positive T-Lymphocytes; CD8-Positive T-Lymphocytes; Cell Separation; Cyclopentanes; Cytokines; Flow Cytometry; Humans; Immunophenotyping; Ionophores; Lymphocyte Activation; Macrolides; Middle Aged; Protein Synthesis Inhibitors; Synovial Membrane; T-Lymphocytes, Helper-Inducer | 1998 |
Presenilin 1 mutations linked to familial Alzheimer's disease increase the intracellular levels of amyloid beta-protein 1-42 and its N-terminally truncated variant(s) which are generated at distinct sites.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Anti-Bacterial Agents; Brefeldin A; Cyclopentanes; Extracellular Space; Gene Expression Regulation; Genetic Linkage; Humans; Intracellular Fluid; Macrolides; Membrane Proteins; Mice; Monensin; Mutation; Peptide Fragments; Presenilin-1; Time Factors; Tumor Cells, Cultured | 1998 |
NSF is required for the brefeldin A-promoted disassembly of the Golgi apparatus.
Topics: Animals; Anti-Bacterial Agents; Brefeldin A; Carrier Proteins; CHO Cells; Cricetinae; Cyclopentanes; Golgi Apparatus; Macrolides; Microscopy, Electron; N-Ethylmaleimide-Sensitive Proteins; Protein Synthesis Inhibitors; Vesicular Transport Proteins | 1998 |
Secretion of Phospholipase Dδ Functions as a Regulatory Mechanism in Plant Innate Immunity.
Topics: Arabidopsis; Arabidopsis Proteins; Ascomycota; Brefeldin A; Cell Membrane; Chitin; Cyclopentanes; Exocytosis; Hydrogen Peroxide; Immunity, Innate; Oxylipins; Phosphatidic Acids; Phospholipase D; Plant Diseases; Qa-SNARE Proteins; R-SNARE Proteins; Reactive Oxygen Species; Signal Transduction; SNARE Proteins | 2019 |