cyclopentane has been researched along with bilobalide in 149 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 19 (12.75) | 18.2507 |
| 2000's | 71 (47.65) | 29.6817 |
| 2010's | 52 (34.90) | 24.3611 |
| 2020's | 7 (4.70) | 2.80 |
| Authors | Studies |
|---|---|
| Sviridov, AF | 1 |
| Ambrogini, P; Bombardelli, E; Bruno, C; Cecchini, T; Cuppini, R; Del Grande, P; Sartini, S | 1 |
| Delaive, E; Drieu, K; Eliaers, F; Janssens, D; Michiels, C; Remacle, J | 1 |
| DeFeudis, FV; Drieu, K; Jean, T; Vasseur, M | 1 |
| Atzori, C; Bombardelli, E; Bruno, A; Chichino, G; Ghione, M; Scaglia, M | 1 |
| Haga, M; Kubota, Y; Matsumoto, T; Miura, K; Sasaki, K; Wada, K; Yagi, M | 1 |
| Ambrogini, P; Bombardelli, E; Bruno, C; Cecchini, T; Cuppini, R; Sartini, S | 1 |
| Culcasi, M; Drieu, K; Maurelli, E; Pietri, S | 1 |
| Chatterjee, SS; Klein, J; Löffelholz, K | 1 |
| Haga, M; Hatta, S; Ohshika, H; Sasaki, K; Wada, K | 2 |
| Damerau, W; Schimke, I; Scholtyssek, H; Wessel, R | 1 |
| Haga, M; Hatta, S; Ohshika, H; Sasaki, K | 1 |
| Ahlemeyer, B; Krieglstein, J; Möwes, A | 1 |
| Biber, A; Koch, E | 1 |
| Drieu, K; Janssens, D; Michiels, C; Remacle, J | 1 |
| Mauri, P; Migliazza, B; Pietta, P | 1 |
| Chatterjee, SS; Hilgert, M; Klein, J; Lehr, M; Weichel, O | 1 |
| Haga, M; Inomata, K; Ohshika, H; Oota, I; Sasaki, K; Wada, K | 1 |
| Lin, Q; Qian, H; Xie, P; Yan, Y | 1 |
| Zhou, LJ; Zhu, XZ | 1 |
| Cheung, F; O, K; Siow, YL | 1 |
| Chen, ZL; Cheng, XF; Song, W; Yin, ML; Zhou, LJ; Zhu, XZ | 1 |
| Chen, ZL; Yin, ML; Zheng, SX; Zhou, LJ; Zhu, XZ | 1 |
| Chen, ZL; Cheng, XF; Guan, HJ; Song, W; Yin, ML; Zhu, XZ | 1 |
| Bombardelli, E; Gardana, C; Mauri, P; Minoggio, M; Morazzoni, P; Pietta, P; Simonetti, P | 1 |
| Chandrasekaran, K; Drieu, K; Fiskum, G; Mehrabian, Z; Spinnewyn, B | 1 |
| Kim, MJ; Lee, HS | 1 |
| Bosetti, F; Dasgupta, SF; Drieu, K; Rapoport, SI; Stella, AM; Tendi, EA | 1 |
| Endo, T; Haga, M; Hatta, S; Sakata, M; Sasaki, K; Tanaka, T; Ueda, N; Wada, K; Yoshimura, T | 1 |
| Bouaziz, N; Michiels, C; Quéré, L; Redon, M; Remacle, J | 1 |
| Davies, JA; Johns, L; Sinclair, AJ | 1 |
| Li, XF; Ma, M; Scherban, K; Tam, YK | 1 |
| Chatterjee, SS; Davies, JA; Jones, FA | 1 |
| Ishii, S; Nakanishi, K; Saito, DR; Shimizu, T; Shindou, H; Strømgaard, K | 1 |
| Chandrasekaran, K; Chinopoulos, C; Drieu, K; Fiskum, G; Mehrabian, Z; Spinnewyn, B | 2 |
| Haga, M; Hatta, S; Itoh, M; Sasaki, K; Wada, K; Yoshimura, T | 1 |
| Berger, JM; Lichtblau, D; Nakanishi, K | 1 |
| Gogös, E | 1 |
| Defeudis, FV | 1 |
| Biber, A; Blume, HH; Kressmann, S; Müller, WE; Schug, B; Wonnemann, M | 1 |
| Ju, XR; Wang, HF | 1 |
| Bermejo, P; Choi, HK; Choi, YH; Erkelens, C; Hazekamp, A; Schilder, Y; Verpoorte, R | 1 |
| Deng, F; Zito, SW | 1 |
| Chebib, M; Duke, RK; Huang, SH; Johnston, GA; Sasaki, K; Wada, K | 2 |
| Chan, VW; Cheung, F; O, K; Siow, YL; Woo, CW | 1 |
| Nishida, S; Satoh, H | 2 |
| Satoh, H | 2 |
| Ahlemeyer, B; Krieglstein, J | 1 |
| Biber, A | 1 |
| Chatterjee, SS; Kondratskaya, EL; Krishtal, OA | 1 |
| Chatterjee, SS; Hilgert, M; Klein, J; Nawrath, H; Rupp, J; Weichel, O | 1 |
| Davies, JA; Johns, L; Jones, FA | 1 |
| Kuribara, H; Maruyama, Y; Weintraub, ST; Yoshihama, T | 1 |
| Chen, YS; Cheng, CY; Liu, CJ; Yao, CH | 1 |
| Tang, C; Wei, X; Yin, C | 1 |
| Chang, TK; Chen, J; Kuo, If | 1 |
| Chiu, HL; Lin, HY; Yang, TC | 1 |
| Kohno, H; Sasaki, K; Sugie, S; Suzuki, R; Tanaka, T; Wada, K; Yoshimura, T | 1 |
| Jaracz, S; Malik, S; Nakanishi, K | 1 |
| Chen, X; Kong, L; Li, X; Sheng, L; Zou, H | 1 |
| van Beek, TA | 1 |
| Hawthorne, R; Lynch, JW | 1 |
| Chang, TK; Chen, J; Teng, XW | 1 |
| Dubber, MJ; Kanfer, I | 1 |
| de Jager, LS; Diachenko, GW; Perfetti, GA | 1 |
| Wang, DP; Yuan, M; Zhang, XQ; Zhou, X | 1 |
| Brenton, AG; Ding, S; Dudley, E; Newton, RP; Plummer, S; Tang, J | 1 |
| Hillert, M; Kiewert, C; Klein, J; Kumar, V; Mdzinarishvili, A | 1 |
| Hartmann, J; Hildmann, O; Kiewert, C; Klein, J; Kumar, V; Naik, RS; Rueda, M | 1 |
| Endoh, K; Shinozuka, K; Sugiyama, T; Taki, Y; Taku, K; Tanabe, H; Umegaki, K | 1 |
| Buckley, F; Sacks, B | 1 |
| Berova, N; Dzyuba, SV; He, J; Nakanishi, K; Petrovic, AG; Polavarapu, PL | 1 |
| Ding, C; Ge, Q; Xie, J; Zhi, X; Zhou, Z | 1 |
| Hartmann, J; Hildmann, O; Hillert, M; Kiewert, C; Klein, J; Kumar, V | 1 |
| Bi, HC; Chen, X; Deng, Y; Ding, L; He, F; Huang, M; Huang, ZY; Liu, YQ; Ou, ZM; Yu, JJ; Zhao, LZ; Zhou, SF | 1 |
| Fei, XF; Gu, ZL; Li, LY; Liang, ZQ; Qin, ZH; Zhao, XL | 1 |
| Biswal, S; Christen, Y; Doré, S; Saleem, S; Zhuang, H | 1 |
| Choi, MS; Goo, GH; Kang, SM; Karigar, CS; Kim, SW; Kim, YD; Min, JY | 1 |
| Shimura, F; Taki, Y; Umegaki, K; Yamada, S; Yamazaki, Y | 1 |
| Bi, HC; Chen, J; Chen, X; Deng, Y; Ding, L; Guan, S; Huang, M; Ou, ZM; Wang, XD; Xu, LJ; Zhao, LZ; Zhou, SF | 1 |
| Basilico, F; Mauri, PL; Morazzoni, P; Riva, A; Rossi, R; Rossoni, G | 1 |
| Brown, MK; Luo, Y | 1 |
| Chaudhary, A; Kaur, P; Singh, B | 1 |
| Liu, LG; Rong, S; Sun, ZD; Xie, BJ; Xu, JQ; Zhang, L; Zhang, YJ | 1 |
| Cao, Z; Cui, C; Hou, Y; Klein, WL; Lacor, PN; Lao, L; Luo, Y; Tchantchou, F | 1 |
| Avula, B; Fisher, S; Khan, IA; Khan, SI; Luo, Y; Madgula, VL; Tchantchou, F; Wang, YH; Yu, YB | 1 |
| Bauer, R; Beubler, E; Dittrich, P; Feizlmayr, E; Pinl, F; Suter, A; Woelkart, K | 1 |
| Kehr, J; Yoshitake, S; Yoshitake, T | 1 |
| Shi, C; Wu, F; Xu, J; Yew, DT; Zhu, Y | 1 |
| Ge, Z; Li, G; Shi, C; Xu, J; Yao, Z; Zou, J | 1 |
| Guo, W; Liu, CH; Maerz, S; Zhu, YZ | 1 |
| Klein, J; Lang, D; Schubert-Zsilavecz, M; Ude, C; Wurglics, M | 1 |
| Duke, RK; Lummis, SC; Thompson, AJ | 1 |
| Cho, BJ; Cho, HJ; Choi, SH; Jang, HC; Kang, SM; Kim, HS; Kim, M; Kim, YB; Lim, S; Park, HS; Park, KS; Shin, H; Yoon, JW | 1 |
| Shi, C; Wu, F; Xu, J; Zou, J | 1 |
| Okada, T; Sato, M; Suzuki, E; Takezawa, R; Usuki, T | 1 |
| Huang, M; Li, X; Pan, YZ; Radecki, L; Rodrigues, AC; Winter, JC; Yu, AM | 1 |
| Kubota, Y; Shinozuka, K; Taki, Y; Umegaki, K; Watanabe, Y; Yamada, S; Yokotani, K | 1 |
| Brown, JJ; Cowell, B; Durden, K; Pszczolkowski, MA; Sellars, S | 1 |
| Liu, J; Shi, C; Wu, FM; Xu, J; Zheng, DD | 1 |
| Baucom, CC; Chang, TK; Lau, AJ; Rajaraman, G; Yang, G | 1 |
| Hartmann, J; Kiewert, C; Klein, J; Lang, D; Mdzinarishvili, A; Schwarzkopf, TM; Sumbria, R | 1 |
| Guan, T; Huang, L; Huang, M; Li, Y; Qian, Y; Tang, X | 1 |
| Cole, AJ; Fu, Y; Han, L; Liu, J; Wang, J | 1 |
| Chen, SN; Lankin, DC; Napolitano, JG; Pauli, GF | 1 |
| Liu, X; Ma, L; Tai, F; Wang, S; Wei, B; Wu, R; Yang, X; Yuan, G | 1 |
| Cao, M; Li, W; Ren, Y; Wang, M; Wang, Y; Wu, W; Yin, Y; Zhu, Z | 1 |
| Huang, H; Li, WZ; Wu, WY; Wu, YY; Yin, YY | 1 |
| Dolan, S; Goldie, M | 1 |
| Klein, J; Koch, KA; Schwarzkopf, TM | 1 |
| Eckert, GP; Hagl, S; Klein, J; Schwarzkopf, TM | 1 |
| Liu, JX; Song, WT; Xu, L; Yao, MJ; Zheng, YQ | 1 |
| Gu, X; Liu, F; Wang, Y; Yan, C; Zhao, H | 1 |
| Han, L; Qu, J; Qu, Q; Wu, LX; Zhan, M; Zhang, W; Zhang, YW; Zhou, HH | 1 |
| Anusree, SS; Nisha, VM; Priyanka, A; Raghu, KG | 1 |
| Jiang, M; Li, J; Liu, W; Liu, Y; Luo, C; Mo, Z; Peng, J; Peng, Q; Yung, KK | 1 |
| Chen, Y; Kang, Q; Lan, Y; Li, H; Liu, N; Ma, Q; Wang, W; Wu, Q; Zhang, Q; Zhang, Y; Zhao, B | 1 |
| Fu, L; Liu, D; Lu, L; Wang, S; Xu, A; Zhu, Y | 1 |
| Geng, T; Si, HH; Sun, XP; Xue, J; Zhao, J | 1 |
| Geng, K; He, J; Kang, JC; Luo, YK; Qian, YX; Zhao, JJ | 1 |
| Shui, L; Song, Z; Tai, F; Wang, S; Wu, R | 1 |
| Gu, SS; Mei, WH; Wang, ZZ; Xiao, W; Zhou, J; Zhou, JM | 1 |
| Fangyu, W; Hui, S | 1 |
| Nisha, VM; Preetha Rani, MR; Priyanka, A; Raghu, KG; Shyni, GL; Sindhu, G | 1 |
| Chen, B; Chen, S; He, Y; Liu, J; Ma, M; Yao, S | 1 |
| Duke, RK; Hinton, T; Johnston, GAR; Ng, CC | 1 |
| Gong, LL; Liang, RX; Wang, L; Xu, HY; Yang, HJ; Yin, XJ; Yuan, HJ | 1 |
| Csupor, D; Czigle, S; Háznagy-Radnai, E; Jedlinszki, N; Tekeľová, D; Tóth, J | 1 |
| Liu, J; Orange, M; Wu, Z; Yang, B; Yao, M; Yi, F; Zheng, Y; Zhu, H | 1 |
| Fan, X; Gong, X; Ke, H; Li, C; Liu, T; Wang, Q; Xiaoyan, L; Zhang, J | 1 |
| Cao, L; Ma, CG; Miao, Q; Song, LJ; Sui, RX; Wang, J; Wang, Q; Xiao, BG; Xiao, W; Yu, JW | 1 |
| Chen, Q; Ding, J; Fan, Y; Hu, G; Hua, J; Tao, T; Xu, S; Yin, N; Zhang, J | 1 |
| Cai, D; Cai, M; Cai, X; Li, X; Wang, G; Wu, T; Xiang, J; Yang, F; Yu, Z; Zhang, J; Zhang, W; Zhu, W | 1 |
| He, H; Nie, J; Wang, R; Xu, M; Yao, J; Yaro, P; Zeng, K; Zeng, S | 1 |
| Li, G; Nan, W; Shi, Q; Wang, S; Wang, Y; Yang, F; Zhang, H | 1 |
| Li, H; Mao, D; Xu, J; Yu, C; Zhang, L; Zhang, Q | 1 |
| Baker, MA; Demoret, RM; Ohtawa, M; Shenvi, RA | 1 |
| Hao, Y; Liu, K; Sun, Y; Wang, W; Wu, D | 1 |
| Dzyuba, SV; Hashizume, D; Satake, M; Sato, M; Suzuki, N; Takenaka, T; Takezawa, R; Usuki, T; Yoshida, Y; Yoshimoto, Y | 1 |
| Muraki, H; Nishimon, S; Nishino, S; Sakai, N; Yamaguchi, M | 1 |
| Dong, HL; Dong, HY; Li, HL; Lin, S; Su, RX; Wu, QL; Wu, ZL; Zhang, WD | 1 |
| Cao, L; Han, QX; Ma, CG; Miao, Q; Ren, SS; Sui, RX; Wang, J; Wang, Q; Xiao, BG; Xiao, W; Yu, JW; Yu, JZ; Zhang, XX | 1 |
| Zhai, H; Zhang, Y | 1 |
| Li, D; Li, K; Wang, J; Wang, Q; Wang, Y; Xie, S; Zhao, J; Zuo, Z | 1 |
4 review(s) available for cyclopentane and bilobalide
| Article | Year |
|---|---|
[Gingkolides and bilobalide: structure, pharmacology, and synthesis].
Topics: Cyclopentanes; Diterpenes; Furans; Ginkgolides; Lactones; Plant Extracts; Platelet Activating Factor; Structure-Activity Relationship | 1991 |
Bilobalide and neuroprotection.
Topics: Animals; Cell Survival; Cerebrovascular Disorders; Cyclopentanes; Diterpenes; Furans; Ginkgo biloba; Ginkgolides; Humans; Neuroprotective Agents; Phytotherapy; Plant Extracts; Plant Leaves | 2002 |
Pharmacological studies supporting the therapeutic use of Ginkgo biloba extract for Alzheimer's disease.
Topics: Alzheimer Disease; Animals; Apoptosis; Brain Ischemia; Cells, Cultured; Cyclopentanes; Diterpenes; Dose-Response Relationship, Drug; Drug Interactions; Flavones; Flavonoids; Furans; Ginkgo biloba; Ginkgolides; Glutamic Acid; Humans; Hypoxia; Lactones; Neurons; Neuroprotective Agents; Plant Extracts; Time Factors | 2003 |
Ginkgolides and bilobalide: their physical, chromatographic and spectroscopic properties.
Topics: Chromatography, Gas; Chromatography, High Pressure Liquid; Chromatography, Thin Layer; Cyclopentanes; Diterpenes; Furans; Ginkgolides; Models, Molecular; Molecular Structure; Spectrum Analysis | 2005 |
4 trial(s) available for cyclopentane and bilobalide
| Article | Year |
|---|---|
Influence of pharmaceutical quality on the bioavailability of active components from Ginkgo biloba preparations.
Topics: Administration, Oral; Adult; Area Under Curve; Biological Availability; Cyclopentanes; Diterpenes; Furans; Gas Chromatography-Mass Spectrometry; Ginkgo biloba; Ginkgolides; Humans; Hydrogen-Ion Concentration; Lactones; Male; Middle Aged; Plant Extracts; Solubility; Technology, Pharmaceutical; Therapeutic Equivalency | 2002 |
Pharmacokinetics of Ginkgo biloba extracts.
Topics: Adult; Aged; Aged, 80 and over; Animals; Area Under Curve; Case-Control Studies; Cross-Over Studies; Cyclopentanes; Diterpenes; Dose-Response Relationship, Drug; Female; Flavonoids; Free Radical Scavengers; Furans; Ginkgo biloba; Ginkgolides; Half-Life; Humans; Lactones; Male; Middle Aged; Plant Extracts; Plants, Medicinal; Rats; Structure-Activity Relationship; Time Factors | 2003 |
Pharmacokinetics of bilobalide, ginkgolide A and B after administration of three different Ginkgo biloba L. preparations in humans.
Topics: Adult; Biological Availability; Cardiovascular Agents; Chromatography, High Pressure Liquid; Cyclopentanes; Female; Furans; Ginkgo biloba; Ginkgolides; Humans; Lactones; Male; Mass Spectrometry; Phytotherapy; Plant Extracts; Tablets; Young Adult | 2010 |
Bilobalide, a unique constituent of Ginkgo biloba, inhibits inflammatory pain in rats.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Capsaicin; Carrageenan; Cyclopentanes; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Routes; Edema; Furans; Ginkgolides; Hindlimb; Hyperalgesia; Inflammation; Male; Pain; Pain Measurement; Pain Threshold; Rats; Rats, Wistar; Sensory System Agents; Vocalization, Animal | 2013 |
141 other study(ies) available for cyclopentane and bilobalide
| Article | Year |
|---|---|
[Progression of multiple innervation of reinnervated rat muscle treated with bilobalide].
Topics: Action Potentials; Animals; Cyclopentanes; Diterpenes; Furans; Ginkgolides; Male; Molecular Structure; Motor Endplate; Nerve Crush; Nerve Regeneration; Rats; Rats, Inbred Strains; Sciatic Nerve | 1991 |
Protection of hypoxia-induced ATP decrease in endothelial cells by ginkgo biloba extract and bilobalide.
Topics: Adenosine Triphosphate; Animals; Biological Transport; Cell Hypoxia; Cells, Cultured; Cyclopentanes; Diterpenes; Dose-Response Relationship, Drug; Endothelium, Vascular; Female; Furans; Ginkgo biloba; Ginkgolides; Glucose; Glycolysis; Humans; Ischemia; Lactates; Mitochondria, Liver; Oxygen Consumption; Plant Extracts; Rats; Rats, Wistar; Time Factors | 1995 |
Effects of repeated treatments with an extract of Ginkgo biloba (EGb 761), bilobalide and ginkgolide B on the electrical activity of pancreatic beta cells of normal or alloxan-diabetic mice: an ex vivo study with intracellular microelectrodes.
Topics: Action Potentials; Animals; Cells, Cultured; Culture Media; Cyclopentanes; Diabetes Mellitus, Experimental; Diterpenes; Female; Furans; Ginkgo biloba; Ginkgolides; Glucose; Intracellular Fluid; Islets of Langerhans; Lactones; Membrane Potentials; Mice; Mice, Inbred Strains; Microelectrodes; Plant Extracts | 1994 |
Activity of bilobalide, a sesquiterpene from Ginkgo biloba, on Pneumocystis carinii.
Topics: Acetone; Animals; Cells, Cultured; Cyclopentanes; Diterpenes; Female; Fibroblasts; Furans; Ginkgolides; Humans; Plant Extracts; Plants, Medicinal; Pneumocystis; Pneumocystis Infections; Rats; Rats, Sprague-Dawley; Trimethoprim, Sulfamethoxazole Drug Combination | 1993 |
Isolation of bilobalide and ginkgolide A from Ginkgo biloba L. shorten the sleeping time induced in mice by anesthetics.
Topics: Anesthetics; Animals; Chloralose; Cyclopentanes; Diterpenes; Furans; Ginkgolides; Hexobarbital; Lactones; Male; Mice; Mice, Inbred Strains; Plant Extracts; Plants, Medicinal; Sleep; Time Factors; Urethane | 1993 |
Regeneration of motor nerves in bilobalide-treated rats.
Topics: Animals; Cyclopentanes; Diterpenes; Furans; Ginkgolides; Male; Membrane Potentials; Molecular Structure; Motor Neurons; Nerve Regeneration; Phosphatidylcholines; Rats; Rats, Sprague-Dawley | 1993 |
Cardioprotective and anti-oxidant effects of the terpenoid constituents of Ginkgo biloba extract (EGb 761).
Topics: Animals; Antioxidants; Cyclic N-Oxides; Cyclopentanes; Diterpenes; Dose-Response Relationship, Drug; Electron Spin Resonance Spectroscopy; Fibrinolytic Agents; Free Radical Scavengers; Furans; Ginkgo biloba; Ginkgolides; Heart; Hemodynamics; Lactones; Male; Myocardial Ischemia; Perfusion; Plant Extracts; Rats; Rats, Wistar; Terpenes | 1997 |
Phospholipid breakdown and choline release under hypoxic conditions: inhibition by bilobalide, a constituent of Ginkgo biloba.
Topics: Animals; Choline; Cyclopentanes; Diterpenes; Drug Evaluation, Preclinical; Furans; Ginkgolides; Hippocampus; Hypoxia, Brain; Logistic Models; Male; Phospholipids; Plant Extracts; Plant Leaves; Rats; Rats, Wistar | 1997 |
Bilobalide, a constituent of Ginkgo biloba L., potentiates drug-metabolizing enzyme activities in mice: possible mechanism for anticonvulsant activity against 4-O-methylpyridoxine-induced convulsions.
Topics: Administration, Oral; Animals; Anticonvulsants; Cyclopentanes; Diterpenes; Dose-Response Relationship, Drug; Enzyme Induction; Furans; Ginkgolides; Injections, Intraperitoneal; Liver; Male; Mice; Pyridoxine; Seizures; Time Factors | 1997 |
Antioxidative activity of ginkgolides against superoxide in an aprotic environment.
Topics: Antioxidants; Cyclopentanes; Dimethyl Sulfoxide; Diterpenes; Electron Spin Resonance Spectroscopy; Free Radical Scavengers; Furans; Ginkgo biloba; Ginkgolides; Plant Extracts; Spectrophotometry, Ultraviolet; Superoxides | 1997 |
Effects of bilobalide on gamma-aminobutyric acid levels and glutamic acid decarboxylase in mouse brain.
Topics: Animals; Brain; Cerebral Cortex; Cyclopentanes; Diterpenes; Furans; gamma-Aminobutyric Acid; Ginkgolides; Glutamate Decarboxylase; Glutamic Acid; Hippocampus; Immunoblotting; Male; Mice; Protein Binding; Receptors, GABA-A; Visual Cortex | 1999 |
Inhibition of serum deprivation- and staurosporine-induced neuronal apoptosis by Ginkgo biloba extract and some of its constituents.
Topics: Animals; Animals, Newborn; Apoptosis; Cell Survival; Cells, Cultured; Chick Embryo; Coloring Agents; Cyclopentanes; Diterpenes; Furans; Ginkgo biloba; Ginkgolides; Hippocampus; Neuroglia; Neurons; Plant Extracts; Plants, Medicinal; Rats; Rats, Inbred F344; Staurosporine | 1999 |
Bioavailability of ginkgolides and bilobalide from extracts of ginkgo biloba using GC/MS.
Topics: Animals; Biological Availability; Cyclopentanes; Diterpenes; Furans; Gas Chromatography-Mass Spectrometry; Ginkgo biloba; Ginkgolides; Half-Life; Lactones; Male; Plant Extracts; Plants, Medicinal; Rats; Rats, Sprague-Dawley; Reproducibility of Results | 1999 |
Protection of mitochondrial respiration activity by bilobalide.
Topics: Animals; Cell Respiration; Cyclopentanes; Diterpenes; Female; Furans; Ginkgolides; In Vitro Techniques; Ischemia; Liver; Mitochondria, Liver; NAD(P)H Dehydrogenase (Quinone); Oxygen Consumption; Perfusion; Protective Agents; Rats; Rats, Wistar | 1999 |
Liquid chromatography/electrospray mass spectrometry of bioactive terpenoids in Ginkgo biloba L.
Topics: Chromatography, Liquid; Cyclopentanes; Diterpenes; Drugs, Chinese Herbal; Furans; Ginkgo biloba; Ginkgolides; Humans; Lactones; Mass Spectrometry; Plant Extracts; Plants, Medicinal; Reference Standards; Terpenes | 1999 |
Bilobalide, a constituent of Ginkgo biloba, inhibits NMDA-induced phospholipase A2 activation and phospholipid breakdown in rat hippocampus.
Topics: Animals; Cells, Cultured; Choline; Cyclopentanes; Diterpenes; Dose-Response Relationship, Drug; Enzyme Activation; Furans; Ginkgo biloba; Ginkgolides; Glycerylphosphorylcholine; Glycine; Hippocampus; Lysophosphatidylcholines; Male; Microdialysis; N-Methylaspartate; Phospholipases A; Phospholipases A2; Phospholipids; Plants, Medicinal; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Seizures | 1999 |
Effects of bilobalide, a sesquiterpene in Ginkgo biloba leaves, on population spikes in rat hippocampal slices.
Topics: Action Potentials; Animals; Cyclopentanes; Diterpenes; Dose-Response Relationship, Drug; Furans; GABA Agonists; Ginkgo biloba; Ginkgolides; Hippocampus; In Vitro Techniques; Male; Muscimol; Neurons; Plant Leaves; Plants, Medicinal; Pyramidal Cells; Rats; Rats, Wistar; Sesquiterpenes | 1999 |
[Assay of terpenes in the leaves of Ginkgo biloba extract and its preparations by in situ fluorometric TLC].
Topics: Chromatography, High Pressure Liquid; Chromatography, Thin Layer; Cyclopentanes; Diterpenes; Drugs, Chinese Herbal; Furans; Ginkgo biloba; Ginkgolides; Lactones; Plant Leaves; Plants, Medicinal; Terpenes | 1997 |
Reactive oxygen species-induced apoptosis in PC12 cells and protective effect of bilobalide.
Topics: Animals; Apoptosis; bcl-2-Associated X Protein; bcl-X Protein; Caspase 3; Caspases; Cyclopentanes; Diterpenes; Furans; Ginkgolides; Neuroprotective Agents; PC12 Cells; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Proto-Oncogene Proteins c-myc; Rats; Reactive Oxygen Species; RNA, Messenger; Tumor Suppressor Protein p53 | 2000 |
Inhibition by ginkgolides and bilobalide of the production of nitric oxide in macrophages (THP-1) but not in endothelial cells (HUVEC).
Topics: Cells, Cultured; Cyclopentanes; Diterpenes; Drug Interactions; Endothelium, Vascular; Free Radical Scavengers; Furans; Gene Expression; Ginkgolides; Humans; Insulin; Insulin Lispro; Lactones; Macrophages; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; RNA, Messenger | 2001 |
Protective effects of bilobalide on amyloid beta-peptide 25-35-induced PC12 cell cytotoxicity.
Topics: Amyloid beta-Peptides; Animals; Catalase; Cell Survival; Cyclopentanes; Diterpenes; Furans; Ginkgolides; Glutathione Peroxidase; L-Lactate Dehydrogenase; Lipid Peroxidation; Neuroprotective Agents; PC12 Cells; Peptide Fragments; Rats; Superoxide Dismutase | 2000 |
Bilobalide promotes expression of glial cell line-derived neurotrophic factor and vascular endothelial growth factor in rat astrocytes.
Topics: Animals; Astrocytes; Cell Line; Cyclopentanes; Diterpenes; Endothelial Growth Factors; Furans; Ginkgo biloba; Ginkgolides; Lymphokines; Neuregulin-1; Plants, Medicinal; Rats; RNA, Messenger; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors | 2000 |
Protective effect of bilobalide against nitric oxide-induced neurotoxicity in PC12 cells.
Topics: Animals; Catalase; Cell Survival; Cyclopentanes; Diterpenes; Furans; Ginkgolides; L-Lactate Dehydrogenase; Lipid Peroxidation; Malondialdehyde; Neuroprotective Agents; Nitric Oxide; PC12 Cells; Rats; Superoxide Dismutase | 2000 |
Liquid chromatography/atmospheric pressure chemical ionization mass spectrometry of terpene lactones in plasma of volunteers dosed with Ginkgo biloba L. extracts.
Topics: Adult; Area Under Curve; Chromatography, Liquid; Cyclopentanes; Diterpenes; Food Deprivation; Furans; Ginkgo biloba; Ginkgolides; Half-Life; Humans; Lactones; Male; Mass Spectrometry; Plant Extracts; Plants, Medicinal | 2001 |
Neuroprotective effects of bilobalide, a component of the Ginkgo biloba extract (EGb 761), in gerbil global brain ischemia.
Topics: Animals; Brain; Brain Ischemia; Cell Count; Cell Death; Cyclopentanes; Cytochrome-c Oxidase Deficiency; Diterpenes; DNA, Mitochondrial; Electron Transport Complex IV; Energy Metabolism; Furans; Gene Expression Regulation, Enzymologic; Gerbillinae; Ginkgo biloba; Ginkgolides; Hippocampus; Male; Nerve Degeneration; Neurons; Neuroprotective Agents; Oxidative Phosphorylation; Plant Extracts; Reperfusion Injury; RNA, Messenger | 2001 |
Selective responses of three Ginkgo biloba leaf-derived constituents on human intestinal bacteria.
Topics: Bifidobacterium; Clostridium perfringens; Cyclopentanes; Diterpenes; Enterobacteriaceae; Escherichia coli; Flavonoids; Furans; Ginkgo biloba; Ginkgolides; Intestines; Kaempferols; Lactones; Plant Extracts; Plant Leaves; Quercetin | 2002 |
Ginkgo biloba extracts EGb 761 and bilobalide increase NADH dehydrogenase mRNA level and mitochondrial respiratory control ratio in PC12 cells.
Topics: Animals; Antioxidants; Cyclopentanes; Diterpenes; Furans; Gene Expression Regulation, Neoplastic; Ginkgo biloba; Ginkgolides; Kinetics; Mitochondria; NADH Dehydrogenase; Oxygen Consumption; PC12 Cells; Pheochromocytoma; Plant Extracts; Rats; RNA, Messenger; Transcription, Genetic | 2002 |
Effects of extract of Ginkgo biloba leaves and its constituents on carcinogen-metabolizing enzyme activities and glutathione levels in mouse liver.
Topics: Animals; Blotting, Western; Carcinogens; Cyclopentanes; Diterpenes; Furans; Ginkgo biloba; Ginkgolides; Glutathione; Glutathione Transferase; Isoenzymes; Lactones; Liver; Mice; NAD(P)H Dehydrogenase (Quinone); Plant Extracts; Plant Leaves | 2002 |
Mitochondrial respiratory chain as a new target for anti-ischemic molecules.
Topics: Adenosine Triphosphate; Animals; Bridged Bicyclo Compounds; Cardiovascular Agents; Cell Adhesion; Cell Hypoxia; Cell Survival; Cells, Cultured; Cyclopentanes; Diterpenes; Dose-Response Relationship, Drug; Electron Transport; Esters; Female; Furans; Ginkgolides; Humans; Ischemia; Malonates; Mitochondria, Liver; Neutrophils; Oxygen Consumption; Rats; Rats, Wistar; Structure-Activity Relationship; Tumor Cells, Cultured | 2002 |
Effects of bilobalide on hypoxia/hypoglycemia-stimulated glutamate efflux from rat cortical brain slices.
Topics: Animals; Cerebral Cortex; Cyclopentanes; Diterpenes; Furans; Ginkgolides; Glutamic Acid; Hypoglycemia; Hypoxia; In Vitro Techniques; Male; Rats; Rats, Wistar | 2002 |
Liquid chromatography-electrospray mass spectrometric studies of ginkgolides and bilobalide using simultaneous monitoring of proton, ammonium and sodium adducts.
Topics: Chromatography, Liquid; Cyclopentanes; Diterpenes; Furans; Ginkgo biloba; Ginkgolides; Lactones; Plant Extracts; Spectrometry, Mass, Electrospray Ionization | 2002 |
Effects of bilobalide on amino acid release and electrophysiology of cortical slices.
Topics: Animals; Aspartic Acid; Cerebral Cortex; Cyclopentanes; Diterpenes; Electrophysiology; Furans; Ginkgolides; Glutamic Acid; In Vitro Techniques; Magnesium; Mice; Mice, Inbred BALB C; Mice, Inbred DBA; N-Methylaspartate; Neurotransmitter Agents; Neurotransmitter Uptake Inhibitors; Nipecotic Acids; Oximes; Potassium; Veratridine | 2002 |
Ginkgolide derivatives for photolabeling studies: preparation and pharmacological evaluation.
Topics: Animals; Binding, Competitive; Calcium Signaling; CHO Cells; Cricetinae; Cyclopentanes; Diterpenes; Fluorescent Dyes; Furans; Ginkgolides; Lactones; Ligands; Mice; Muscle, Skeletal; Myocardium; Photoaffinity Labels; Platelet Activating Factor; Platelet Membrane Glycoproteins; Radioligand Assay; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Structure-Activity Relationship; Terpenes | 2002 |
Bilobalide, a component of the Ginkgo biloba extract (EGb 761), protects against neuronal death in global brain ischemia and in glutamate-induced excitotoxicity.
Topics: Administration, Oral; Animals; Brain Ischemia; Cell Death; Cerebellum; Cyclopentanes; Diterpenes; Electron Transport Complex IV; Furans; Gerbillinae; Ginkgo biloba; Ginkgolides; Glutamic Acid; Hippocampus; Male; Neurons; Neuroprotective Agents; Plant Extracts; Reperfusion Injury | 2002 |
Effects of chronic administration of bilobalide on amino acid levels in mouse brain.
Topics: Administration, Oral; Amino Acids; Animals; Brain; Cerebral Cortex; Corpus Striatum; Cyclopentanes; Diterpenes; Furans; Ginkgolides; Hippocampus; Male; Mice; Neuroprotective Agents; Taurine | 2002 |
Efficient extraction of ginkgolides and bilobalide from Ginkgo biloba leaves.
Topics: Chromatography, High Pressure Liquid; Chromatography, Thin Layer; Cyclopentanes; Diterpenes; Furans; Ginkgo biloba; Ginkgolides; Magnetic Resonance Spectroscopy; Plant Leaves; Spectrometry, Mass, Fast Atom Bombardment; Terpenes | 2002 |
Identification and the retention index of bilobalide and ginkgolides using capillary gas chromatography.
Topics: Chromatography, Gas; Cyclopentanes; Diterpenes; Furans; Ginkgolides; Lactones | 2002 |
Rapid analysis of terpene lactones in extract of Ginkgo biloba L. by high performance liquid chromatography.
Topics: Chromatography, High Pressure Liquid; Cyclopentanes; Diterpenes; Drugs, Chinese Herbal; Furans; Ginkgo biloba; Ginkgolides; Lactones; Terpenes | 2000 |
Quantitative analysis of bilobalide and ginkgolides from Ginkgo biloba leaves and Ginkgo products using (1)H-NMR.
Topics: Cyclopentanes; Diterpenes; Evaluation Studies as Topic; Furans; Ginkgo biloba; Ginkgolides; Lactones; Magnetic Resonance Spectroscopy; Plant Extracts; Plant Leaves; Protons | 2003 |
Development and validation of a gas chromatographic-mass spectrometric method for simultaneous identification and quantification of marker compounds including bilobalide, ginkgolides and flavonoids in Ginkgo biloba L. extract and pharmaceutical preparatio
Topics: Calibration; Cyclopentanes; Diterpenes; Flavonoids; Furans; Gas Chromatography-Mass Spectrometry; Ginkgo biloba; Ginkgolides; Lactones; Pharmaceutical Preparations; Plant Extracts; Reproducibility of Results; Sensitivity and Specificity | 2003 |
Bilobalide, a sesquiterpene trilactone from Ginkgo biloba, is an antagonist at recombinant alpha1beta2gamma2L GABA(A) receptors.
Topics: Animals; Bicuculline; Cyclopentanes; Diterpenes; Dose-Response Relationship, Drug; Furans; GABA Antagonists; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Ginkgo biloba; Ginkgolides; Humans; Membrane Potentials; Oocytes; Picrotoxin; Receptors, GABA-A; Recombinant Proteins; Sesterterpenes; Xenopus laevis | 2003 |
Homocysteine stimulates inducible nitric oxide synthase expression in macrophages: antagonizing effect of ginkgolides and bilobalide.
Topics: Antioxidants; Cell Line; Cyclopentanes; Diterpenes; Dose-Response Relationship, Drug; Furans; Ginkgolides; Homocysteine; Humans; Lactones; Macrophages; Models, Biological; Monocytes; NF-kappa B; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; RNA, Messenger; Superoxides; Time Factors | 2003 |
Bilobalide prevents reduction of gamma-aminobutyric acid levels and glutamic acid decarboxylase activity induced by 4-O-methylpyridoxine in mouse hippocampus.
Topics: Animals; Cerebral Cortex; Cyclopentanes; Diterpenes; Furans; gamma-Aminobutyric Acid; Ginkgo biloba; Ginkgolides; Glutamate Decarboxylase; Glutamic Acid; Hippocampus; Male; Mice; Neostriatum; Nerve Tissue Proteins; Pyridoxine | 2000 |
Mechanisms for the vasodilations induced by Ginkgo biloba extract and its main constituent, bilobalide, in rat aorta.
Topics: Animals; Aorta, Thoracic; Calcium; Cyclopentanes; Diterpenes; Dose-Response Relationship, Drug; Drug Antagonism; Drug Combinations; Endothelium, Vascular; Furans; Ginkgo biloba; Ginkgolides; Indomethacin; omega-N-Methylarginine; Plant Extracts; Rats; Rats, Wistar; Tetraethylammonium; Vasodilation; Vasodilator Agents | 2003 |
Effects of ginkgo biloba extract and bilobalide, a main constituent, on the ionic currents in guinea pig ventricular cardiomyocytes.
Topics: Action Potentials; Animals; Cyclopentanes; Diterpenes; Furans; Ginkgo biloba; Ginkgolides; Guinea Pigs; Heart Ventricles; In Vitro Techniques; Ion Channels; Membrane Potentials; Muscle Cells; Myocardium; Patch-Clamp Techniques; Plant Extracts | 2003 |
Structure-activity studies with Ginkgo biloba extract constituents as receptor-gated chloride channel blockers and modulators.
Topics: Animals; Animals, Newborn; Cerebellum; Chloride Channels; Cyclopentanes; Diterpenes; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Drug Interactions; Electric Conductivity; Furans; gamma-Aminobutyric Acid; Ginkgo biloba; Ginkgolides; Glycine; Hippocampus; In Vitro Techniques; Inhibitory Concentration 50; Lactones; Neurons; Patch-Clamp Techniques; Plant Extracts; Platelet Activating Factor; Pyrans; Rats; Rats, Wistar; Structure-Activity Relationship | 2003 |
Excitotoxic hippocampal membrane breakdown and its inhibition by bilobalide: role of chloride fluxes.
Topics: 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid; Animals; Calcium; Calcium Isotopes; Cell Membrane; Chlorides; Choline; Cyclopentanes; Diterpenes; Diuretics; Dizocilpine Maleate; Drug Interactions; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Furans; Furosemide; Ginkgolides; Glycine; Hippocampus; In Vitro Techniques; Male; N-Methylaspartate; Potassium; Pyrrolidinones; Rats; Rats, Wistar; Synaptosomes | 2003 |
Effects of bilobalide on cerebral amino acid neurotransmission.
Topics: Animals; Animals, Newborn; Cerebral Cortex; Cyclopentanes; Diterpenes; Dose-Response Relationship, Drug; Drug Interactions; Epilepsy, Reflex; Epilepsy, Tonic-Clonic; Female; Furans; Ginkgolides; Glutamic Acid; Hypoglycemia; Hypoxia; In Vitro Techniques; Male; Mice; Mice, Inbred BALB C; Mice, Inbred DBA; Neurotransmitter Uptake Inhibitors; Nipecotic Acids; Oximes; Potassium; Rats; Rats, Wistar; Time Factors; Veratridine | 2003 |
Neuroprotective effects of bilobalide, a component of Ginkgo biloba extract (EGb 761) in global brain ischemia and in excitotoxicity-induced neuronal death.
Topics: Animals; Animals, Newborn; Brain Ischemia; Cell Count; Cell Death; Cell Survival; Cells, Cultured; Cerebellum; Cyclopentanes; Disease Models, Animal; Diterpenes; Dose-Response Relationship, Drug; Electron Transport Complex IV; Furans; Gerbillinae; Ginkgo biloba; Ginkgolides; Glutamic Acid; Glycine; Hippocampus; In Situ Hybridization; In Vitro Techniques; Inhibitory Concentration 50; Male; Membrane Proteins; Plant Extracts; Rats; Reperfusion; RNA, Messenger; Saccharomyces cerevisiae Proteins; Trauma, Nervous System | 2003 |
An anxiolytic-like effect of Ginkgo biloba extract and its constituent, ginkgolide-A, in mice.
Topics: Animals; Anti-Anxiety Agents; Behavior, Animal; Benzodiazepines; Caffeine; Cyclopentanes; Diazepam; Diterpenes; Dose-Response Relationship, Drug; Furans; Ginkgo biloba; Ginkgolides; Lactones; Male; Maze Learning; Mice; Mice, Inbred Strains; Molecular Structure; Motor Activity; Phenobarbital; Plant Extracts; Plants, Medicinal; Sleep | 2003 |
Effect of bilobalide on peripheral nerve regeneration.
Topics: Animals; Axons; Cell Division; Cyclopentanes; Diterpenes; Electrophysiology; Furans; Ginkgolides; Muscle, Skeletal; Myelin Sheath; Nerve Regeneration; Neurons; Peripheral Nerves; Rats; Rats, Sprague-Dawley; Rubber; Sciatic Nerve; Silicones; Time Factors | 2004 |
Analysis of ginkgolides and bilobalide in Ginkgo biloba L. extract injections by high-performance liquid chromatography with evaporative light scattering detection.
Topics: Chromatography, High Pressure Liquid; Cyclopentanes; Diterpenes; Furans; Ginkgo biloba; Ginkgolides; Plant Extracts | 2003 |
Effect of Ginkgo biloba extract on rat hepatic microsomal CYP1A activity: role of ginkgolides, bilobalide, and flavonols.
Topics: Animals; Cyclopentanes; Cytochrome P-450 CYP1A1; Cytochrome P-450 CYP1A2; Diterpenes; Dose-Response Relationship, Drug; Enzyme Activation; Flavonols; Furans; Ginkgo biloba; Ginkgolides; Lactones; Male; Microsomes, Liver; Plant Extracts; Rats; Rats, Sprague-Dawley | 2004 |
Determination of ginkgolide A, B, and bilobalide in biloba L. extracts by microdialysis-HPLC.
Topics: Calibration; Chromatography, High Pressure Liquid; Cyclopentanes; Diterpenes; Furans; Ginkgo biloba; Ginkgolides; Lactones; Microdialysis; Plant Extracts; Plant Leaves | 2004 |
Preventive effects of extract of leaves of ginkgo (Ginkgo biloba) and its component bilobalide on azoxymethane-induced colonic aberrant crypt foci in rats.
Topics: Administration, Oral; Animals; Azoxymethane; Carcinogens; Chemoprevention; Colonic Neoplasms; Cyclopentanes; Cytochrome P-450 Enzyme System; Diet; Diterpenes; Furans; Ginkgo biloba; Ginkgolides; Glutathione Transferase; Immunohistochemistry; Male; Phytotherapy; Plant Extracts; Plant Leaves; Precancerous Conditions; Proliferating Cell Nuclear Antigen; Rats; Rats, Inbred F344 | 2004 |
Isolation of ginkgolides A, B, C, J and bilobalide from G. biloba extracts.
Topics: Cyclopentanes; Diterpenes; Furans; Ginkgo biloba; Ginkgolides; Lactones; Molecular Structure; Plant Extracts | 2004 |
Age-related changes in the vasodilating actions of Ginkgo biloba extract and its main constituent, bilobalide, in rat aorta.
Topics: Age Factors; Animals; Aorta; Cyclopentanes; Diterpenes; Furans; Ginkgo biloba; Ginkgolides; In Vitro Techniques; Male; Plant Extracts; Rats; Rats, Wistar; Vasodilation | 2005 |
[Applications of two-dimensional liquid chromatography coupled to mass spectrometry for the separation and identification of compounds in ginkgo biloba extracts].
Topics: Chromatography, High Pressure Liquid; Cyclopentanes; Drugs, Chinese Herbal; Flavonols; Furans; Ginkgo biloba; Ginkgolides; Kaempferols; Lactones; Medicine, Chinese Traditional; Monosaccharides; Quercetin; Rutin; Spectrometry, Mass, Electrospray Ionization | 2005 |
A picrotoxin-specific conformational change in the glycine receptor M2-M3 loop.
Topics: Allosteric Site; Cyclopentanes; Cysteine; Dimerization; Diterpenes; DNA, Complementary; Dose-Response Relationship, Drug; Electrophysiology; Furans; Ginkgolides; Glycine; Humans; Inhibitory Concentration 50; Kinetics; Mesylates; Mutagenesis, Site-Directed; Mutation; Picrotoxin; Protein Binding; Protein Conformation; Protein Structure, Secondary; Protein Structure, Tertiary; Receptors, Glycine; Time Factors | 2005 |
Suppression of pacemaker activity by Ginkgo biloba extract and its main constituent, bilobalide in rat sino-atrial nodal cells.
Topics: Action Potentials; Animals; Arrhythmias, Cardiac; Biological Clocks; Calcium Channel Blockers; Cyclopentanes; Diterpenes; Furans; Ginkgo biloba; Ginkgolides; Ion Channels; Patch-Clamp Techniques; Plant Extracts; Rats; Rats, Wistar; Sinoatrial Node | 2005 |
Distinct role of bilobalide and ginkgolide A in the modulation of rat CYP2B1 and CYP3A23 gene expression by Ginkgo biloba extract in cultured hepatocytes.
Topics: Animals; Cells, Cultured; Cyclopentanes; Cytochrome P-450 Enzyme System; Diterpenes; Furans; Gene Expression Regulation, Enzymologic; Ginkgo biloba; Ginkgolides; Hepatocytes; Lactones; Male; Plant Extracts; Rats; Rats, Sprague-Dawley; RNA, Messenger; Testosterone | 2006 |
Mixed antagonistic effects of bilobalide at rho1 GABAC receptor.
Topics: Animals; Chloride Channels; Cyclopentanes; Diterpenes; Dose-Response Relationship, Drug; Female; Furans; GABA Antagonists; gamma-Aminobutyric Acid; Gene Transfer Techniques; Ginkgolides; Humans; Neural Inhibition; Oocytes; Patch-Clamp Techniques; Picrotoxin; Plant Extracts; Protein Subunits; Receptors, GABA; Recombinant Fusion Proteins; Xenopus laevis | 2006 |
Determination of terpene trilactones in Ginkgo biloba solid oral dosage forms using HPLC with evaporative light scattering detection.
Topics: Administration, Oral; Calibration; Chemistry, Pharmaceutical; Chromatography, High Pressure Liquid; Cyclopentanes; Diterpenes; Furans; Ginkgo biloba; Ginkgolides; Lactones; Light; Methanol; Pharmaceutical Preparations; Quality Control; Reproducibility of Results; Scattering, Radiation; Temperature; Terpenes; Water | 2006 |
Analysis of ginkgolides and bilobalide in food products using LC-APCI-MS.
Topics: Beverages; Chromatography, Liquid; Cyclopentanes; Dietary Supplements; Diterpenes; Food Analysis; Furans; Ginkgo biloba; Ginkgolides; Indicators and Reagents; Mass Spectrometry; Reference Standards; Reproducibility of Results; Tea | 2006 |
[Quantitative determination of ginkgolides by liquid chromatography-electrospray mass spectrometry].
Topics: Chromatography, Liquid; Cyclopentanes; Drugs, Chinese Herbal; Furans; Ginkgo biloba; Ginkgolides; Lactones; Plant Leaves; Plants, Medicinal; Spectrometry, Mass, Electrospray Ionization; Tablets | 2005 |
Quantitative determination of major active components in Ginkgo biloba dietary supplements by liquid chromatography/mass spectrometry.
Topics: Chromatography, High Pressure Liquid; Cyclopentanes; Dietary Supplements; Flavonols; Furans; Ginkgo biloba; Ginkgolides; Kaempferols; Plant Extracts; Quercetin; Rutin; Spectrometry, Mass, Electrospray Ionization | 2006 |
Bilobalide prevents ischemia-induced edema formation in vitro and in vivo.
Topics: Animals; Body Water; Brain Chemistry; Brain Edema; Brain Ischemia; Cell Death; Cyclopentanes; Furans; Ginkgolides; Hippocampus; In Vitro Techniques; Male; Middle Cerebral Artery; Rats; Rats, Sprague-Dawley; Stroke; Water Intoxication | 2007 |
Role of GABAergic antagonism in the neuroprotective effects of bilobalide.
Topics: Animals; Area Under Curve; Bicuculline; Brain Edema; Bridged Bicyclo Compounds, Heterocyclic; Choline; Cyclopentanes; Drug Interactions; Excitatory Amino Acid Agonists; Furans; GABA Antagonists; gamma-Aminobutyric Acid; Ginkgolides; Hippocampus; In Vitro Techniques; Male; N-Methylaspartate; Neuroprotective Agents; Nonlinear Dynamics; Picrotoxin; Rats; Rats, Sprague-Dawley; Synaptosomes | 2007 |
Bilobalide in Ginkgo biloba extract is a major substance inducing hepatic CYPs.
Topics: Animals; Cyclopentanes; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Enzyme Induction; Furans; Ginkgo biloba; Ginkgolides; In Vitro Techniques; Male; Mice; Mice, Inbred ICR; Microsomes, Liver; Plant Extracts | 2007 |
Drug treatment improves memory in mice.
Topics: Animals; Central Nervous System Stimulants; Chromosomes, Human, Pair 21; Cyclopentanes; Disease Models, Animal; Down Syndrome; Furans; GABA Antagonists; Ginkgolides; Humans; Maze Learning; Memory; Mice; Mice, Transgenic; Neuropsychological Tests; Pentylenetetrazole; Picrotoxin | 2007 |
Spectroscopic investigation of Ginkgo biloba terpene trilactones and their interaction with amyloid peptide Abeta(25-35).
Topics: Amyloid beta-Peptides; Circular Dichroism; Cyclopentanes; Furans; Ginkgo biloba; Ginkgolides; Lactones; Peptides; Spectrophotometry, Infrared; Terpenes; Time Factors; Vibration | 2008 |
Simultaneous determination of ginkgolides A, B, C and bilobalide in plasma by LC-MS/MS and its application to the pharmacokinetic study of Ginkgo biloba extract in rats.
Topics: Animals; Chromatography, High Pressure Liquid; Cyclopentanes; Female; Furans; Ginkgo biloba; Ginkgolides; Lactones; Male; Plant Extracts; Quality Control; Rats; Rats, Sprague-Dawley; Reproducibility of Results; Sensitivity and Specificity; Tandem Mass Spectrometry | 2008 |
Role of glycine receptors and glycine release for the neuroprotective activity of bilobalide.
Topics: Animals; Binding Sites; Binding, Competitive; Brain Edema; Brain Ischemia; Chlorides; Choline; Cyclopentanes; Excitatory Amino Acid Agonists; Furans; Ginkgolides; Glycine; Hippocampus; Male; Membrane Lipids; N-Methylaspartate; Neuroprotective Agents; Organ Culture Techniques; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate | 2008 |
Induction of cytochrome P450s by terpene trilactones and flavonoids of the Ginkgo biloba extract EGb 761 in rats.
Topics: Animals; Cyclopentanes; Cytochrome P-450 Enzyme System; Enzyme Induction; Flavonoids; Furans; Gene Expression; Ginkgo biloba; Ginkgolides; Kaempferols; Lactones; Male; Microsomes, Liver; Plant Extracts; Quercetin; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger | 2008 |
Bilobalide inhibits 6-OHDA-induced activation of NF-kappaB and loss of dopaminergic neurons in rat substantia nigra.
Topics: Animals; Cyclopentanes; Disease Models, Animal; Dose-Response Relationship, Drug; Furans; Ginkgolides; Male; Neurons; Neuroprotective Agents; NF-kappa B; Oxidopamine; Parkinson Disease; Rats; Rats, Sprague-Dawley; Substantia Nigra; Sympatholytics | 2008 |
Ginkgo biloba extract neuroprotective action is dependent on heme oxygenase 1 in ischemic reperfusion brain injury.
Topics: Animals; Antioxidants; Brain Damage, Chronic; Brain Ischemia; Cells, Cultured; Cerebrovascular Circulation; Cyclopentanes; Drug Evaluation, Preclinical; Enzyme Induction; Excitatory Amino Acid Antagonists; Furans; Ginkgo biloba; Ginkgolides; Glutamic Acid; Heme Oxygenase-1; Infarction, Middle Cerebral Artery; Male; Membrane Proteins; Mice; Mice, Inbred C57BL; Mice, Knockout; Nerve Tissue Proteins; Neurons; Neuroprotective Agents; Plant Extracts; Reperfusion Injury; Response Elements | 2008 |
Effect of biotic elicitors on the accumulation of bilobalide and ginkgolides in Ginkgo biloba cell cultures.
Topics: Candida albicans; Cell Proliferation; Cells, Cultured; Culture Media, Conditioned; Cyclopentanes; Data Interpretation, Statistical; Furans; Ginkgo biloba; Ginkgolides; Phytoalexins; Sesquiterpenes; Staphylococcus aureus; Terpenes | 2009 |
Time-dependent induction of hepatic cytochrome P450 enzyme activity and mRNA expression by bilobalide in rats.
Topics: Animals; Cyclopentanes; Cytochrome P-450 Enzyme System; Enzyme Induction; Furans; Gene Expression Regulation; Ginkgo biloba; Ginkgolides; Liver; Male; Plant Extracts; Rats; Rats, Wistar; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Time Factors | 2009 |
Induction of cytochrome P450 3A by the Ginkgo biloba extract and bilobalides in human and rat primary hepatocytes.
Topics: Adult; Aged; Animals; Cyclopentanes; Cytochrome P-450 CYP3A; Dose-Response Relationship, Drug; Enzyme Induction; Female; Furans; Gene Expression Regulation, Enzymologic; Ginkgo biloba; Ginkgolides; Hepatocytes; Humans; Lactones; Male; Middle Aged; Nifedipine; Plant Extracts; Rats; Rats, Sprague-Dawley; RNA, Messenger | 2008 |
Liquid chromatography/atmospheric pressure chemical ionization ion trap mass spectrometry of bilobalide in plasma and brain of rats after oral administration of its phospholipidic complex.
Topics: Administration, Oral; Animals; Atmospheric Pressure; Biological Availability; Brain; Calibration; Cyclopentanes; Furans; Ginkgolides; Male; Mass Spectrometry; Phospholipids; Rats; Reference Standards | 2009 |
Bilobalide modulates serotonin-controlled behaviors in the nematode Caenorhabditis elegans.
Topics: Age Factors; Aldicarb; Amyloid beta-Peptides; Animals; Animals, Genetically Modified; Behavior, Animal; Caenorhabditis elegans; Caenorhabditis elegans Proteins; Chloride Channels; Cholinesterase Inhibitors; Cyclopentanes; Dopamine; Dose-Response Relationship, Drug; Furans; Ginkgolides; Humans; Locomotion; Mutation; Piperazines; Pyridines; Receptors, Serotonin; Reproduction; Serotonin; Serotonin Antagonists | 2009 |
Optimization of extraction technique and validation of developed RP-HPLC-ELSD method for determination of terpene trilactones in Ginkgo biloba leaves.
Topics: Calibration; Chemistry, Pharmaceutical; Chromatography, High Pressure Liquid; Cyclopentanes; Furans; Ginkgo biloba; Ginkgolides; Lactones; Light; Methanol; Nitrogen; Plant Extracts; Plant Leaves; Reproducibility of Results; Scattering, Radiation; Temperature; Terpenes; Water | 2009 |
The mixture of procyanidins extracted from the lotus seed pod and bilobalide ameliorates scopolamine-induced memory impairment in mice.
Topics: Animals; Behavior, Animal; Cyclopentanes; Disease Models, Animal; Drug Therapy, Combination; Furans; Ginkgolides; Lotus; Male; Maze Learning; Memory Disorders; Mice; Mice, Inbred Strains; Plant Extracts; Proanthocyanidins; Reaction Time; Scopolamine; Seeds; Statistics, Nonparametric | 2009 |
Stimulation of neurogenesis and synaptogenesis by bilobalide and quercetin via common final pathway in hippocampal neurons.
Topics: Alzheimer Disease; Animals; Blotting, Western; Cyclic AMP Response Element-Binding Protein; Cyclopentanes; Dose-Response Relationship, Drug; Furans; Ginkgo biloba; Ginkgolides; Hippocampus; Mice; Neurogenesis; Phosphorylation; Plant Extracts; Quercetin; Rats; Rats, Sprague-Dawley; Synapses | 2009 |
Intestinal and blood-brain barrier permeability of ginkgolides and bilobalide: in vitro and in vivo approaches.
Topics: Animals; Blood-Brain Barrier; Cell Line; Cyclopentanes; Dogs; Dose-Response Relationship, Drug; Furans; Ginkgolides; Humans; Intestines; Molecular Structure; Rats | 2010 |
The Ginkgo biloba extract EGb 761(R) and its main constituent flavonoids and ginkgolides increase extracellular dopamine levels in the rat prefrontal cortex.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Corpus Striatum; Cyclopentanes; Dopamine; Flavonoids; Furans; Ginkgo biloba; Ginkgolides; Homovanillic Acid; Male; Microdialysis; Plant Extracts; Prefrontal Cortex; Rats; Rats, Sprague-Dawley; Serotonin | 2010 |
Bilobalide prevents apoptosis through activation of the PI3K/Akt pathway in SH-SY5Y cells.
Topics: Apoptosis; Caspase 3; Cell Line, Tumor; Cells, Cultured; Cyclopentanes; DNA Fragmentation; Furans; Ginkgolides; Humans; Neurons; Neuroprotective Agents; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Signal Transduction | 2010 |
Bilobalide protects mitochondrial function in ovariectomized rats by up-regulation of mRNA and protein expression of cytochrome c oxidase subunit I.
Topics: Adenosine Triphosphate; Animals; Cyclopentanes; Electron Transport Complex IV; Female; Furans; Ginkgolides; Hippocampus; Humans; Mitochondria; Neuroprotective Agents; Ovariectomy; Protein Subunits; Rats; Rats, Wistar; RNA, Messenger; Up-Regulation | 2011 |
Anti-ischaemic effects of bilobalide on neonatal rat cardiomyocytes and the involvement of the platelet-activating factor receptor.
Topics: 1-Alkyl-2-acetylglycerophosphocholine Esterase; Animals; Animals, Newborn; Cardiotonic Agents; Cell Hypoxia; Cell Survival; Cells, Cultured; Cyclopentanes; Furans; Gene Expression; Ginkgolides; Lactones; Male; Myocardial Ischemia; Myocardium; Myocytes, Cardiac; Platelet Membrane Glycoproteins; Rats, Sprague-Dawley; Receptors, G-Protein-Coupled | 2011 |
Brain permeability of bilobalide as probed by microdialysis before and after middle cerebral artery occlusion in mice.
Topics: Animals; Biological Availability; Blood-Brain Barrier; Brain; Chromatography, Liquid; Cyclopentanes; Disease Models, Animal; Female; Furans; Ginkgo biloba; Ginkgolides; Infarction, Middle Cerebral Artery; Injections, Intraperitoneal; Mass Spectrometry; Mice; Microdialysis; Permeability; Time Factors | 2010 |
Binding sites for bilobalide, diltiazem, ginkgolide, and picrotoxinin at the 5-HT3 receptor.
Topics: Amino Acid Sequence; Animals; Binding Sites; Cyclopentanes; Diltiazem; Female; Furans; Ginkgolides; Humans; Molecular Sequence Data; Picrotoxin; Radioligand Assay; Receptors, Serotonin, 5-HT3; Sequence Homology, Amino Acid; Sesterterpenes; Xenopus laevis | 2011 |
EGb761, a Ginkgo biloba extract, is effective against atherosclerosis in vitro, and in a rat model of type 2 diabetes.
Topics: Animals; Apoptosis; Atherosclerosis; Caspase 3; Cell Adhesion; Cell Adhesion Molecules; Cell Movement; Cell Proliferation; Cells, Cultured; Cyclopentanes; Diabetes Mellitus, Type 2; Disease Models, Animal; Furans; Ginkgo biloba; Ginkgolides; Humans; Immunoblotting; Kaempferols; Male; Muscle, Smooth, Vascular; Plant Extracts; Quercetin; Rats; Rats, Inbred OLETF; Reverse Transcriptase Polymerase Chain Reaction; Tunica Intima; U937 Cells | 2011 |
Bilobalide regulates soluble amyloid precursor protein release via phosphatidyl inositol 3 kinase-dependent pathway.
Topics: Amyloid beta-Protein Precursor; Cell Line, Tumor; Cyclopentanes; Furans; Ginkgolides; Humans; Phosphatidylinositol 3-Kinases; Protein Kinase C | 2011 |
The facilitative effects of bilobalide, a unique constituent of Ginkgo biloba, on synaptic transmission and plasticity in hippocampal subfields.
Topics: Animals; Cyclopentanes; Electric Stimulation; Furans; Ginkgolides; Hippocampus; Long-Term Synaptic Depression; Male; Neuronal Plasticity; Perforant Pathway; Rats; Rats, Wistar; Synaptic Transmission | 2011 |
MicroRNA expression is differentially altered by xenobiotic drugs in different human cell lines.
Topics: Antineoplastic Agents, Phytogenic; ATP-Binding Cassette Transporters; Caco-2 Cells; Cell Line, Tumor; Cocaine; Cyclopentanes; Dexamethasone; Dopamine Uptake Inhibitors; Down-Regulation; Drug Interactions; Drug Resistance, Multiple; Furans; Gene Expression; Ginkgolides; Humans; Inactivation, Metabolic; Inverted Repeat Sequences; MicroRNAs; Neuronal Plasticity; Vinblastine; Xenobiotics | 2011 |
Ginkgo biloba extract attenuates warfarin-mediated anticoagulation through induction of hepatic cytochrome P450 enzymes by bilobalide in mice.
Topics: Animals; Anticoagulants; Blood Coagulation; Coagulants; Cyclopentanes; Cytochrome P-450 Enzyme System; Enzyme Induction; Furans; Ginkgo biloba; Ginkgolides; Herb-Drug Interactions; Lactones; Liver; Male; Mice; Mice, Inbred ICR; Plant Extracts; Warfarin | 2012 |
Effects of Ginkgo biloba constituents on fruit-infesting behavior of codling moth (Cydia pomonella) in apples.
Topics: Animals; Cyclopentanes; Fruit; Furans; Ginkgo biloba; Ginkgolides; Insecticides; Lactones; Larva; Malus; Moths; Plant Extracts; Salicylates | 2011 |
The phosphatidyl inositol 3 kinase-glycogen synthase kinase 3β pathway mediates bilobalide-induced reduction in amyloid β-peptide.
Topics: Amyloid beta-Peptides; Animals; Cell Line; Cyclopentanes; Furans; Ginkgolides; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Mice; Phosphatidylinositol 3-Kinase; Signal Transduction | 2012 |
Species-dependent and receptor-selective action of bilobalide on the function of constitutive androstane receptor and pregnane X receptor.
Topics: Animals; Cell Line, Tumor; Cells, Cultured; Constitutive Androstane Receptor; Cyclopentanes; Furans; Ginkgolides; Hep G2 Cells; Hepatocytes; Humans; Pregnane X Receptor; Rats; Receptors, Cytoplasmic and Nuclear; Receptors, Steroid; Species Specificity | 2012 |
Neuroprotective effects of bilobalide are accompanied by a reduction of ischemia-induced glutamate release in vivo.
Topics: Animals; Brain; Brain Ischemia; Cyclopentanes; Dose-Response Relationship, Drug; Female; Furans; Ginkgolides; Glutamic Acid; Mice; Microdialysis; Neuroprotective Agents | 2011 |
Different neuroprotective responses of Ginkgolide B and bilobalide, the two Ginkgo components, in ischemic rats with hyperglycemia.
Topics: Animals; Blood Glucose; Cerebrovascular Circulation; Cyclopentanes; Furans; Ginkgolides; Hyperglycemia; Infarction, Middle Cerebral Artery; Lactones; Male; Neuroprotective Agents; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species | 2012 |
Co-encapsulation and sustained-release of four components in ginkgo terpenes from injectable PELGE nanoparticles.
Topics: Animals; Capsules; Chemistry, Pharmaceutical; Cyclopentanes; Delayed-Action Preparations; Drug Delivery Systems; Furans; Ginkgo biloba; Ginkgolides; Half-Life; Macrophages; Male; Nanoparticles; Phytotherapy; Polyesters; Polyethylene Glycols; Rats; Rats, Sprague-Dawley | 2012 |
Complete 1H NMR spectral analysis of ten chemical markers of Ginkgo biloba.
Topics: Cyclopentanes; Furans; Ginkgo biloba; Ginkgolides; Kaempferols; Lactones; Magnetic Resonance Spectroscopy; Molecular Structure; Protons; Quercetin; Reference Standards; Rutin; Stereoisomerism | 2012 |
Effects of bilobalide on anxiety, spatial learning, memory and levels of hippocampal glucocorticoid receptors in male Kunming mice.
Topics: Animals; Anxiety; Behavior, Animal; Cyclopentanes; Dose-Response Relationship, Drug; Furans; Ginkgo biloba; Ginkgolides; Hippocampus; Male; Maze Learning; Memory; Mice; Mice, Inbred Strains; Motor Activity; Phytotherapy; Plant Extracts; Receptors, Glucocorticoid | 2012 |
Protective effects of bilobalide on Aβ(25-35) induced learning and memory impairments in male rats.
Topics: Amyloid beta-Peptides; Animals; Brain; Cyclopentanes; Enzyme-Linked Immunosorbent Assay; Furans; Ginkgolides; Glutathione; Learning Disabilities; Male; Malondialdehyde; Maze Learning; Memory Disorders; Nitric Oxide Synthase; Peptide Fragments; Rats; Rats, Sprague-Dawley; Superoxide Dismutase; Tumor Necrosis Factor-alpha | 2013 |
Protective effect of bilobalide on learning and memory impairment in rats with vascular dementia.
Topics: Animals; Apoptosis; Brain; Cyclopentanes; Dementia, Vascular; Disease Models, Animal; Furans; Ginkgo biloba; Ginkgolides; Glutathione; Learning; Male; Malondialdehyde; Memory; Neurons; Neuroprotective Agents; Nitric Oxide Synthase; Plant Leaves; Rats; Rats, Sprague-Dawley; Superoxide Dismutase; Tumor Necrosis Factor-alpha | 2013 |
Neurodegeneration after transient brain ischemia in aged mice: beneficial effects of bilobalide.
Topics: Adenosine Triphosphate; Aging; Animals; Brain Infarction; Cyclopentanes; Disease Models, Animal; Extracellular Fluid; Female; Furans; Ginkgolides; Glucose; Glutamic Acid; Infarction, Middle Cerebral Artery; Locomotion; Mice; Microdialysis; Mitochondria; Multienzyme Complexes; Neurodegenerative Diseases; Neuroprotective Agents; Oxidative Phosphorylation | 2013 |
Neuroprotection by bilobalide in ischemia: improvement of mitochondrial function.
Topics: Animals; Brain Ischemia; Cyclopentanes; Female; Furans; Ginkgolides; Glucose; Glutamic Acid; Infarction, Middle Cerebral Artery; Mice; Microdialysis; Mitochondria; Neostriatum; Neuroprotective Agents; Oxygen Consumption; Permeability | 2013 |
[Study on effect of weinaokang and bilobalide on autophagy and neurogenesis induced by focal cerebral ischemia reperfusion].
Topics: Animals; Autophagy; Brain Ischemia; Cyclopentanes; Drugs, Chinese Herbal; Furans; Ginkgolides; Male; Neurogenesis; Neurons; Rats; Rats, Sprague-Dawley; Reperfusion Injury | 2013 |
[Microfluidic evaporative light scattering detector coupled with capillary liquid chromatography and its application to Ginkgo biloba extract analysis].
Topics: Chromatography, High Pressure Liquid; Cyclopentanes; Drugs, Chinese Herbal; Furans; Ginkgo biloba; Ginkgolides; Lactones; Microfluidics; Plant Extracts; Scattering, Radiation; Terpenes | 2013 |
Inhibitory effects of phytochemicals on metabolic capabilities of CYP2D6(*)1 and CYP2D6(*)10 using cell-based models in vitro.
Topics: Berberine; Cell Line, Tumor; Chromatography, High Pressure Liquid; Coumarins; Cyclooctanes; Cyclopentanes; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP2D6 Inhibitors; Furans; Ginkgolides; Hep G2 Cells; Humans; Isoflavones; Kinetics; Lignans; Luteolin; Phytochemicals; Polycyclic Compounds | 2014 |
Bilobalide attenuates hypoxia induced oxidative stress, inflammation, and mitochondrial dysfunctions in 3T3-L1 adipocytes via its antioxidant potential.
Topics: 3T3-L1 Cells; Adipocytes; Animals; Antioxidants; Cell Hypoxia; Cyclopentanes; Furans; Ginkgolides; Inflammation; Mice; Mitochondria; Obesity; Oxidative Stress | 2014 |
Neuroprotective effects of bilobalide on cerebral ischemia and reperfusion injury are associated with inhibition of pro-inflammatory mediator production and down-regulation of JNK1/2 and p38 MAPK activation.
Topics: Animals; Brain Ischemia; Cyclopentanes; Disease Models, Animal; Down-Regulation; Enzyme Activation; Furans; Ginkgolides; Male; MAP Kinase Signaling System; Neuroprotective Agents; p38 Mitogen-Activated Protein Kinases; Rats; Rats, Sprague-Dawley; Reperfusion Injury | 2014 |
Enhanced dissolution rate and oral bioavailability of Ginkgo biloba extract by preparing solid dispersion via hot-melt extrusion.
Topics: Animals; Biological Availability; Cyclopentanes; Furans; Ginkgo biloba; Ginkgolides; Kaempferols; Lactones; Male; Molecular Structure; Plant Extracts; Quercetin; Rats, Sprague-Dawley; Solubility | 2015 |
Bilobalide protection of normal human melanocytes from hydrogen peroxide-induced oxidative damage via promotion of antioxidase expression and inhibition of endoplasmic reticulum stress.
Topics: Antioxidants; Cell Survival; Cells, Cultured; Cyclopentanes; Endoplasmic Reticulum Stress; Furans; Ginkgolides; HSP70 Heat-Shock Proteins; Humans; Hydrogen Peroxide; Melanocytes; Oxidants; Oxidative Stress; Plant Extracts; Reactive Oxygen Species; Vitiligo | 2016 |
[Absolute bioavailability of ginkgolide compounds in rats].
Topics: Animals; Biological Availability; Chromatography, High Pressure Liquid; Cyclopentanes; Furans; Ginkgolides; Lactones; Male; Rats; Rats, Sprague-Dawley; Tandem Mass Spectrometry | 2015 |
A Bilobalide-Producing Endophytic Fungus, Pestalotiopsis uvicola from Medicinal Plant Ginkgo biloba.
Topics: Cyclopentanes; Endophytes; Furans; Ginkgo biloba; Ginkgolides; Plant Leaves; Plants, Medicinal; Xylariales | 2016 |
Bilobalide alleviates depression-like behavior and cognitive deficit induced by chronic unpredictable mild stress in mice.
Topics: Animals; Behavior, Animal; Cognition Disorders; Corticosterone; Cyclopentanes; Depression; Discrimination Learning; Disease Models, Animal; Furans; Ginkgolides; Hypothalamo-Hypophyseal System; Male; Maze Learning; Mice; Neuroprotective Agents; Pituitary-Adrenal System; Stress, Psychological | 2016 |
Ginkgolides and bilobalide protect BV2 microglia cells against OGD/reoxygenation injury by inhibiting TLR2/4 signaling pathways.
Topics: Animals; Apoptosis; Cell Hypoxia; Cell Line; Cyclopentanes; Cytokines; Enzyme-Linked Immunosorbent Assay; Furans; Ginkgolides; Glucose; Mice; Microglia; Microscopy, Fluorescence; Myeloid Differentiation Factor 88; Neuroprotective Agents; Signal Transduction; Toll-Like Receptor 2; Toll-Like Receptor 4; Transcription Factor RelA | 2016 |
Protective effects of bilobalide against ethanol-induced gastric ulcer in vivo/vitro.
Topics: Animals; Cell Line; Cell Survival; Cyclopentanes; Epithelial Cells; Ethanol; Female; Furans; Ginkgolides; Humans; Malondialdehyde; Mice; Mice, Inbred BALB C; Specific Pathogen-Free Organisms; Stomach; Stomach Ulcer; Superoxide Dismutase | 2017 |
Bilobalide abates inflammation, insulin resistance and secretion of angiogenic factors induced by hypoxia in 3T3-L1 adipocytes by controlling NF-κB and JNK activation.
Topics: Adipocytes; Anti-Inflammatory Agents; Cell Line; Cyclopentanes; Furans; Ginkgolides; Humans; Hypoxia; Inflammation; Insulin Receptor Substrate Proteins; Insulin Resistance; MAP Kinase Kinase 4; Neovascularization, Pathologic; NF-kappa B; Obesity; Signal Transduction; Transcriptional Activation | 2017 |
New urea-modified paper substrate for enhanced analytical performance of negative ion mode paper spray mass spectrometry.
Topics: Cyclopentanes; Furans; Ginkgo biloba; Ginkgolides; Mass Spectrometry; Paper; Salicylic Acid; Silanes; Urea | 2017 |
Effects of bilobalide, ginkgolide B and picrotoxinin on GABA
Topics: Animals; Cyclopentanes; Dose-Response Relationship, Drug; Electrophysiological Phenomena; Furans; GABA Modulators; Ginkgo biloba; Ginkgolides; Humans; Lactones; Picrotoxin; Receptors, GABA-A; Sesterterpenes; Terpenes; Xenopus laevis | 2017 |
[Simultaneous determination of seven bioactive compounds and pharmacokinetics in rat plasma after oral administration of Yindan Xinnaotong Ruanjiaonang by UPLC-MS/MS].
Topics: Administration, Oral; Animals; Chromatography, High Pressure Liquid; Cyclopentanes; Drugs, Chinese Herbal; Furans; Ginkgolides; Kaempferols; Quercetin; Rats; Rats, Sprague-Dawley; Reproducibility of Results; Tandem Mass Spectrometry | 2017 |
Ginkgo biloba Food Supplements on the European Market - Adulteration Patterns Revealed by Quality Control of Selected Samples.
Topics: Chromatography, High Pressure Liquid; Cyclopentanes; Dietary Supplements; Drug Contamination; Europe; Furans; Gas Chromatography-Mass Spectrometry; Ginkgo biloba; Ginkgolides; Plant Preparations; Quality Control | 2018 |
By Activating Akt/eNOS Bilobalide B Inhibits Autophagy and Promotes Angiogenesis Following Focal Cerebral Ischemia Reperfusion.
Topics: Animals; Apoptosis; Autophagy; Brain; Caspase 3; Cyclopentanes; Disease Models, Animal; Furans; Ginkgolides; Infarction, Middle Cerebral Artery; Male; Microtubule-Associated Proteins; Neovascularization, Physiologic; Neuroprotective Agents; Nitric Oxide; Nitric Oxide Synthase Type III; Proto-Oncogene Proteins c-akt; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Vascular Endothelial Growth Factor A | 2018 |
Chemical analysis, pharmacological activity and process optimization of the proportion of bilobalide and ginkgolides in Ginkgo biloba extract.
Topics: Animals; Chromatography, High Pressure Liquid; Cyclopentanes; Disease Models, Animal; Embryo, Nonmammalian; Fibrinolytic Agents; Furans; Ginkgo biloba; Ginkgolides; Humans; Mass Spectrometry; Models, Animal; Phenylhydrazines; Plant Extracts; Plant Leaves; Quality Control; Technology, Pharmaceutical; Thrombosis; Zebrafish | 2018 |
Protective and therapeutic role of Bilobalide in cuprizone-induced demyelination.
Topics: Animals; Autoantibodies; Behavior, Animal; Corpus Callosum; Cuprizone; Cyclopentanes; Cytokines; Demyelinating Diseases; Disease Models, Animal; Furans; Ginkgolides; Humans; Immunity, Humoral; Inflammation; Inflammation Mediators; Male; Mice; Mice, Inbred C57BL; Multiple Sclerosis; Myelin-Oligodendrocyte Glycoprotein; Neuroprotective Agents; Oligodendroglia | 2019 |
Enhancing the Astrocytic Clearance of Extracellular α-Synuclein Aggregates by Ginkgolides Attenuates Neural Cell Injury.
Topics: alpha-Synuclein; Animals; Astrocytes; Autophagy; Cell Line, Tumor; Culture Media, Conditioned; Cyclopentanes; Endocytosis; Extracellular Space; Furans; Ginkgolides; Humans; Lysosomes; Mice, Inbred C57BL; Neurons; Proteasome Endopeptidase Complex; Protein Aggregates; Proteolysis; Recombinant Proteins; Ubiquitin | 2019 |
Bilobalide protects astrocytes from oxygen and glucose deprivation-induced oxidative injury by upregulating manganese superoxide dismutase.
Topics: Astrocytes; Cyclopentanes; Furans; Ginkgo biloba; Ginkgolides; Glucose; Humans; Neuroprotective Agents; Oxygen; Plant Extracts; Reactive Oxygen Species; Superoxide Dismutase | 2019 |
Influence of organic anion transporter 1/3 on the pharmacokinetics and renal excretion of ginkgolides and bilobalide.
Topics: Animals; Biological Transport; Cyclopentanes; Dogs; Furans; Ginkgolides; HEK293 Cells; Humans; Kidney; Madin Darby Canine Kidney Cells; Male; Organic Anion Transport Protein 1; Organic Anion Transporters, Sodium-Independent; Rats; Renal Elimination; Tissue Distribution | 2019 |
Ginkgolide B and bilobalide promote the growth and increase β-catenin expression in hair follicle dermal papilla cells of American minks.
Topics: Animals; beta Catenin; Cell Proliferation; Cell Survival; Cyclopentanes; Dermis; Furans; Ginkgo biloba; Ginkgolides; Hair Follicle; Lactones; Mink; Signal Transduction | 2019 |
Bilobalide alleviates IL-17-induced inflammatory injury in ATDC5 cells by downregulation of microRNA-125a.
Topics: Animals; Cell Line, Tumor; Cell Movement; Cell Survival; Cyclopentanes; Disease Models, Animal; Down-Regulation; Furans; Ginkgo biloba; Ginkgolides; Inflammation; Interleukin-17; JNK Mitogen-Activated Protein Kinases; Matrix Metalloproteinases; Mice; MicroRNAs; Molecular Mimicry; NF-kappa B; Plant Extracts; Signal Transduction; Spondylitis, Ankylosing; Transfection | 2019 |
Concise asymmetric synthesis of (-)-bilobalide.
Topics: Chemistry Techniques, Analytical; Cyclopentanes; Furans; Ginkgo biloba; Ginkgolides; Oxidation-Reduction | 2019 |
Bilobalide alleviates tumor necrosis factor-alpha-induced pancreatic beta-cell MIN6 apoptosis and dysfunction through upregulation of miR-153.
Topics: Animals; Apoptosis; Cell Line, Tumor; Cyclopentanes; Furans; Ginkgolides; Insulin; Mice; MicroRNAs; Nitric Oxide Synthase Type II; Ribosomal Protein S6 Kinases, 70-kDa; Signal Transduction; TOR Serine-Threonine Kinases; Transcriptional Activation; Tumor Necrosis Factor-alpha; Up-Regulation | 2020 |
Bilobalide and PC12 cells: A structure activity relationship study.
Topics: Amyloid beta-Peptides; Animals; Cell Proliferation; Cells, Cultured; Crystallography, X-Ray; Cyclopentanes; Dose-Response Relationship, Drug; Furans; Ginkgolides; Models, Molecular; Molecular Structure; Neurons; Neuroprotective Agents; PC12 Cells; Peptide Fragments; Rats; Structure-Activity Relationship | 2020 |
Intraperitoneal injection of ginkgolide B, a major active compound of Ginkgo biloba, dose-dependently increases the amount of wake and decreases non-rapid eye movement sleep in C57BL/6 mice.
Topics: Animals; Cyclopentanes; Dose-Response Relationship, Drug; Electroencephalography; Furans; Ginkgo biloba; Ginkgolides; Injections, Intraperitoneal; Lactones; Male; Mice; Mice, Inbred C57BL; Plant Extracts; Sleep Stages; Wakefulness | 2020 |
A new bilobalide isomer and two cis-coumaroylated flavonol glycosides from Ginkgo biloba leaves.
Topics: Bilobalides; Cyclopentanes; Flavonols; Furans; Ginkgo biloba; Ginkgolides; Glycosides; Plant Leaves | 2020 |
The therapeutic potential of bilobalide on experimental autoimmune encephalomyelitis (EAE) mice.
Topics: Animals; Apoptosis; Cell Polarity; Cells, Cultured; Cyclopentanes; Cytokines; Encephalomyelitis, Autoimmune, Experimental; Female; Furans; Ginkgolides; Macrophage Activation; Macrophages; Mice; Mice, Inbred C57BL; Microglia; Nerve Regeneration; Oligodendroglia; Remyelination; T-Lymphocytes | 2020 |
Bilobalide assuages morphine-induced addiction in hippocampal neuron cells through upregulation of microRNA-101.
Topics: Animals; Animals, Newborn; Cells, Cultured; Cyclopentanes; Furans; Ginkgo biloba; Ginkgolides; Hippocampus; Indazoles; MAP Kinase Signaling System; MicroRNAs; Morphine; Neurons; Orexin Receptors; Oxaliplatin; Piperazines; Plant Extracts; Protein Kinase C; Proto-Oncogene Proteins c-fos; Rats; Rats, Wistar; Transfection; Up-Regulation | 2020 |
Enhanced anti-amnestic effect of donepezil by Ginkgo biloba extract (EGb 761) via further improvement in pro-cholinergic and antioxidative activities.
Topics: Acetylcholinesterase; Amnesia; Animals; Antioxidants; Behavior, Animal; Brain; Cell Line; Cholinergic Agents; Cognitive Dysfunction; Cyclopentanes; Disease Models, Animal; Donepezil; Drug Therapy, Combination; Furans; Ginkgo biloba; Ginkgolides; Humans; Male; Malondialdehyde; Maze Learning; Nootropic Agents; Plant Extracts; Rats, Wistar; Superoxide Dismutase | 2021 |