cyclopentane has been researched along with baclofen in 18 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 9 (50.00) | 29.6817 |
| 2010's | 8 (44.44) | 24.3611 |
| 2020's | 1 (5.56) | 2.80 |
| Authors | Studies |
|---|---|
| Froestl, W; Kaupmann, K; Koller, M; Lampert, C; Lingenhoehl, K; Mosbacher, J; Pozza, MF; Urwyler, S | 1 |
| Bettler, B; Chaperon, F; Cryan, JF; Froestl, W; Gentsch, C; Kaupmann, K; Kelly, PH; Lingenhoehl, K; Mombereau, C; Spooren, WP | 1 |
| Cryan, JF; Froestl, W; Markou, A; Slattery, DA | 1 |
| Desrayaud, S; Gjoni, T; Imobersteg, S; Urwyler, S | 1 |
| Cryan, JF; Kaupmann, K; Lhuillier, L; Mombereau, C | 1 |
| Carai, MA; Colombo, G; Fantini, N; Froestl, W; Gessa, GL; Maccioni, P | 1 |
| Gjoni, T; Urwyler, S | 2 |
| Colombo, G; Maccioni, P | 1 |
| Halbout, B; Heidbreder, CA; Hutcheson, DM; Quarta, D; Valerio, E | 1 |
| Hampson, DR; Pacey, LK; Tharmalingam, S | 1 |
| Gannon, RL; Millan, MJ | 1 |
| Capra, A; Carai, MA; Colombo, G; Corelli, F; Gessa, GL; Hyytiä, P; Lobina, C; Loi, B; Lumeng, L; Maccioni, P; Mugnaini, C; Pasquini, S; Zaru, A | 1 |
| Adelfinger, L; Besseyrias, V; Bettler, B; Fritzius, T; Gassmann, M; Jacquier, V; Rajalu, M | 1 |
| Colombo, G; Corelli, F; Gessa, GL; Leite-Morris, KA; Maccioni, P; Malherbe, P; Mugnaini, C; Thomas, AW; Vargiolu, D | 1 |
| Brown, JW; Ma, J; Moeller, A; Nimmrich, V; Rueter, LE; Schmidt, M; Turner, SC; van der Kam, E; Zhang, M | 1 |
| Ahmad, SU; Kumar, J; Mohamed, IN; Pakri Mohamed, RM | 1 |
| Brizzi, A; Castelli, MP; Corelli, F; Mostallino, R; Mugnaini, C | 1 |
2 review(s) available for cyclopentane and baclofen
| Article | Year |
|---|---|
Role of the GABA(B) receptor in alcohol-seeking and drinking behavior.
Topics: Alcohol Drinking; Alcoholism; Allosteric Regulation; Animals; Baclofen; Cyclopentanes; GABA Modulators; Humans; Mice; Motor Activity; Pyrimidines; Rats; Receptors, GABA-B | 2009 |
Novel Pharmacotherapeutic Approaches in Treatment of Alcohol Addiction.
Topics: Alcohol Deterrents; Alcoholism; Animals; Aripiprazole; Baclofen; Cyclopentanes; Gabapentin; Humans; Naltrexone; Quetiapine Fumarate | 2018 |
16 other study(ies) available for cyclopentane and baclofen
| Article | Year |
|---|---|
N,N'-Dicyclopentyl-2-methylsulfanyl-5-nitro-pyrimidine-4,6-diamine (GS39783) and structurally related compounds: novel allosteric enhancers of gamma-aminobutyric acidB receptor function.
Topics: Allosteric Regulation; Animals; Baclofen; CHO Cells; Cricetinae; Cyclopentanes; GABA Agonists; GABA-B Receptor Agonists; gamma-Aminobutyric Acid; Guanosine 5'-O-(3-Thiotriphosphate); Hippocampus; Humans; Kinetics; Oocytes; Potassium Channels; Pyrimidines; Radioligand Assay; Signal Transduction; Structure-Activity Relationship; Sulfur Radioisotopes; Xenopus | 2003 |
Behavioral characterization of the novel GABAB receptor-positive modulator GS39783 (N,N'-dicyclopentyl-2-methylsulfanyl-5-nitro-pyrimidine-4,6-diamine): anxiolytic-like activity without side effects associated with baclofen or benzodiazepines.
Topics: Animals; Anti-Anxiety Agents; Avoidance Learning; Baclofen; Benzodiazepines; Body Temperature; Cyclopentanes; Drug Combinations; Fever; GABA Agonists; GABA-B Receptor Agonists; Male; Maze Learning; Mice; Mice, Inbred BALB C; Motor Activity; Pyrimidines; Rats; Rats, Sprague-Dawley; Receptors, GABA-B; Rotarod Performance Test; Stress, Physiological; Time Factors; Traction | 2004 |
The GABAB receptor-positive modulator GS39783 and the GABAB receptor agonist baclofen attenuate the reward-facilitating effects of cocaine: intracranial self-stimulation studies in the rat.
Topics: Analysis of Variance; Anesthetics, Local; Animals; Baclofen; Behavior, Animal; Cocaine; Cyclopentanes; Dose-Response Relationship, Drug; Drug Interactions; GABA Agents; Male; Pyrimidines; Rats; Rats, Sprague-Dawley; Reward; Self Stimulation | 2005 |
The positive allosteric modulator GS39783 enhances GABA(B) receptor-mediated inhibition of cyclic AMP formation in rat striatum in vivo.
Topics: Animals; Baclofen; Colforsin; Corpus Striatum; Cyclic AMP; Cyclopentanes; Dose-Response Relationship, Drug; Drug Interactions; GABA Agonists; GABA Antagonists; Male; Microdialysis; Phosphinic Acids; Pyrimidines; Radioimmunoassay; Rats; Rats, Wistar; Receptors, GABA-A; Time Factors | 2006 |
GABA(B) receptor-positive modulation decreases selective molecular and behavioral effects of cocaine.
Topics: Animals; Baclofen; Behavior, Addictive; Brain; Cocaine; Cocaine-Related Disorders; Corpus Striatum; Cyclic AMP Response Element-Binding Protein; Cyclopentanes; Disease Models, Animal; Dopamine; Dopamine and cAMP-Regulated Phosphoprotein 32; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; GABA Agonists; Hyperkinesis; Male; Mice; Mice, Inbred C57BL; Proto-Oncogene Proteins c-fos; Pyrimidines; Receptors, GABA-B; Signal Transduction; Synaptic Transmission | 2007 |
Specific reduction of alcohol's motivational properties by the positive allosteric modulator of the GABAB receptor, GS39783--comparison with the effect of the GABAB receptor direct agonist, baclofen.
Topics: Alcoholism; Animals; Baclofen; Behavior, Animal; Central Nervous System Depressants; Cyclopentanes; Disease Models, Animal; Dose-Response Relationship, Drug; Drinking Behavior; Drug Interactions; Ethanol; GABA Agonists; GABA-B Receptor Agonists; Male; Motivation; Pyrimidines; Rats; Receptors, GABA-B; Reinforcement, Psychology; Self Administration | 2008 |
Receptor activation involving positive allosteric modulation, unlike full agonism, does not result in GABAB receptor desensitization.
Topics: Allosteric Regulation; Animals; Baclofen; Benzoates; Biophysical Phenomena; Calcium; Cells, Cultured; Cerebral Cortex; Chlorocebus aethiops; Cyclic AMP; Cyclopentanes; Dose-Response Relationship, Drug; Embryo, Mammalian; GABA Agonists; gamma-Aminobutyric Acid; Humans; Mice; Mice, Inbred BALB C; Neurons; Organophosphorus Compounds; Pyrimidines; Receptors, GABA-B | 2008 |
Changes in the properties of allosteric and orthosteric GABAB receptor ligands after a continuous, desensitizing agonist pretreatment.
Topics: Allosteric Regulation; Animals; Baclofen; CHO Cells; Cricetinae; Cricetulus; Cyclic AMP; Cyclopentanes; GABA-B Receptor Agonists; GABA-B Receptor Antagonists; gamma-Aminobutyric Acid; Humans; Ligands; Pyrimidines; Rats; Receptors, GABA-B | 2009 |
The GABA-B positive modulator GS39783 decreases psychostimulant conditioned-reinforcement and conditioned-reward.
Topics: Allosteric Regulation; Amphetamine; Animals; Association Learning; Baclofen; Central Nervous System Stimulants; Cocaine; Cocaine-Related Disorders; Conditioning, Operant; Cues; Cyclopentanes; Dose-Response Relationship, Drug; Injections, Intraperitoneal; Male; Motivation; Motor Activity; Pyrimidines; Rats; Rats, Inbred Strains; Receptors, GABA-B; Reinforcement Schedule; Reward; Self Administration | 2011 |
Subchronic administration and combination metabotropic glutamate and GABAB receptor drug therapy in fragile X syndrome.
Topics: Animals; Anticonvulsants; Baclofen; Benzamides; Blotting, Western; Cyclopentanes; Drug Interactions; Drug Tolerance; Epilepsy, Reflex; Excitatory Amino Acid Antagonists; Fragile X Mental Retardation Protein; Fragile X Syndrome; GABA Agonists; GABA Modulators; Mice; Mice, Inbred C57BL; Mice, Knockout; Pyrazoles; Pyridines; Pyrimidines; Receptors, GABA-B; Receptors, Kainic Acid; Receptors, Metabotropic Glutamate | 2011 |
Positive allosteric modulators at GABAB receptors exert intrinsic actions and enhance the influence of baclofen on light-induced phase shifts of hamster circadian activity rhythms.
Topics: Animals; Baclofen; Benzofurans; Circadian Rhythm; Cricetinae; Cyclopentanes; Dose-Response Relationship, Drug; GABA Antagonists; GABA Modulators; GABA-A Receptor Agonists; GABA-B Receptor Antagonists; Light; Male; Mesocricetus; Morpholines; Motor Activity; Pyrimidines; Receptors, GABA-A | 2011 |
Comparison of the effect of the GABAΒ receptor agonist, baclofen, and the positive allosteric modulator of the GABAB receptor, GS39783, on alcohol self-administration in 3 different lines of alcohol-preferring rats.
Topics: Alcohol Drinking; Allosteric Regulation; Animals; Baclofen; Cyclopentanes; Ethanol; GABA Modulators; GABA-B Receptor Agonists; Male; Pyrimidines; Rats; Reinforcement Schedule; Self Administration; Species Specificity | 2012 |
Pharmacological characterization of GABAB receptor subtypes assembled with auxiliary KCTD subunits.
Topics: Allosteric Regulation; Animals; Baclofen; Cells, Cultured; CHO Cells; Cricetulus; Cyclopentanes; G Protein-Coupled Inwardly-Rectifying Potassium Channels; GABA Modulators; GABA-B Receptor Agonists; gamma-Aminobutyric Acid; GTP-Binding Proteins; HEK293 Cells; Hippocampus; Humans; Mice; Neurons; Potassium; Pyrimidines; Rats; Receptors, GABA-B; Recombinant Proteins | 2015 |
Inhibition of alcohol self-administration by positive allosteric modulators of the GABAB receptor in rats: lack of tolerance and potentiation of baclofen.
Topics: Alcohol Drinking; Allosteric Regulation; Animals; Baclofen; Benzofurans; Cyclopentanes; Drug Synergism; Drug Tolerance; Ethanol; Male; Pyrimidines; Rats; Receptors, GABA-B; Self Administration | 2015 |
Anticonvulsant effects of structurally diverse GABA(B) positive allosteric modulators in the DBA/2J audiogenic seizure test: Comparison to baclofen and utility as a pharmacodynamic screening model.
Topics: Acoustic Stimulation; Allosteric Regulation; Allosteric Site; Animals; Animals, Newborn; Anticonvulsants; Baclofen; Cyclopentanes; Drug Interactions; GABA Agonists; Guanosine 5'-O-(3-Thiotriphosphate); Male; Mice; Mice, Inbred DBA; Morpholines; Motor Activity; Protein Binding; Pyrazoles; Pyrimidines; Seizures; Sulfur Isotopes | 2016 |
Structure optimization of positive allosteric modulators of GABA
Topics: Allosteric Regulation; Baclofen; Benzofurans; Binding Sites; Cyclization; Cyclopentanes; Drug Evaluation, Preclinical; GABA Modulators; GABA-B Receptor Agonists; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Norbornanes; Protein Binding; Pyrimidines; Receptors, GABA-B; Structure-Activity Relationship | 2020 |