Compounds > cyclopentane
Page last updated: 2024-08-21

cyclopentane and 1-(4-(6-bromobenzo(1,3)dioxol-5-yl)-3a,4,5,9b-tetrahydro-3h-cyclopenta(c)quinolin-8-yl)ethanone

cyclopentane has been researched along with 1-(4-(6-bromobenzo(1,3)dioxol-5-yl)-3a,4,5,9b-tetrahydro-3h-cyclopenta(c)quinolin-8-yl)ethanone in 126 studies

Research

Studies (126)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's11 (8.73)29.6817
2010's103 (81.75)24.3611
2020's12 (9.52)2.80

Authors

AuthorsStudies
Albanito, L; Andò, S; Carpino, A; Lappano, R; Madeo, A; Maggiolini, M; Musti, AM; Oprea, TI; Prossnitz, ER; Rago, V; Vivacqua, A1
Brailoiu, E; Brailoiu, GC; Dun, NJ; Dun, SL; Mizuo, K; Oprea, TI; Prossnitz, ER; Sklar, LA1
Bonhomme, E; Cody, DB; Dehghani, B; Elenich, LA; Kelly, MJ; Magrisso, IJ; Murphy, SJ; Offner, H; Rick, EA; Rosenbaum, JS; Subramanian, S; Vandenbark, AA; Wang, C1
Dina, OA; Goswami, C; Hucho, T; Kuhn, J; Levine, JD; Suckow, V1
Pang, Y; Thomas, P1
Arterburn, JB; Brailoiu, E; Brailoiu, GC; Dun, NJ; Dun, SL; Gao, X; Oprea, TI; Prossnitz, ER1
Dehghani, B; Kaler, LJ; Li, Y; Offner, H; Proctor, T; Vandenbark, AA; Wang, C1
Brosnihan, KB; Chappell, MC; Cohen, JA; Gallagher, PE; Lindsey, SH1
Gibbs, RB; Hammond, R; Mauk, R; Nelson, D; Ninaci, D1
Blasko, E; Dennis, MK; Gualtieri, G; Halks-Miller, M; Haskell, CA; Horuk, R; Karpus, WJ; Leung, S; Mahmoudi, M; Prossnitz, ER1
Deschamps, AM; Murphy, E1
Broughton, BR; Miller, AA; Sobey, CG1
Ariazi, EA; Arterburn, JB; Black, MA; Brailoiu, E; Cunliffe, HE; Donato, AL; Dun, NJ; Jordan, VC; Oprea, TI; Prossnitz, ER; Shupp, HA; Slifker, MJ; Yerrum, S1
Chan, ES; Chan, QK; Ho, SM; Lam, HM; Lau, KM; Lee, AY; Ng, CF; Ng, HK1
Birnbaumer, L; Li, Y; Teng, CT1
Arterburn, JB; Bologa, C; Burai, R; Curpan, R; Oprea, T; Prossnitz, ER; Ramesh, C; Shorty, M; Sklar, LA1
Abarbanell, AM; Herrmann, JL; Manukyan, MC; Meldrum, DR; Poynter, JA; Wang, Y; Weil, BR1
Lazari, MF; Lucas, TF; Porto, CS; Royer, C; Siu, ER1
Baretella, O; Barton, M; Meyer, MR; Prossnitz, ER1
Gibbs, RB; Hammond, R; Nelson, D1
Chappell, MC; Groban, L; Jessup, JA; Lindsey, SH; Wang, H1
Baldetorp, B; Holm, A; Leeb-Lundberg, LM; Nilsson, BO; Olde, B1
Das, SK; Gao, F; Ma, X; Ostmann, AB1
Carver, KA; Chappell, MC; Lindsey, SH; Prossnitz, ER1
Dina, OA; Fernández-Ballester, G; Ferrer-Montiel, A; Goswami, C; Hucho, T; Kuhn, J; Levine, JD1
Amisten, S; Balhuizen, A; Kumar, R; Lundquist, I; Salehi, A1
Prossnitz, ER; Sharma, G1
Brunsing, RL; Prossnitz, ER1
Brosnihan, KB; Chappell, MC; Gallagher, PE; Lindsey, SH; Yamaleyeva, LM1
Arterburn, JB; Brailoiu, E; Brailoiu, GC; Dun, EC; Gao, X; Oprea, TI; Tica, AA; Tica, OS1
Jayasinghe, BS; Volz, DC1
Kastenberger, I; Lutsch, C; Schwarzer, C1
Chagas, C; Groban, L; Jessup, JA; Lin, MS; Lindsey, SH; Wang, H1
Grände, PO; Holm, A; Leeb-Lundberg, LM; Ludueña, RF; Nilsson, BO; Olde, B; Prasad, V1
Häring, J; Lattrich, C; Lubig, J; Ortmann, O; Schüler, S; Springwald, A; Treeck, O1
Arterburn, JB; Benamar, K; Brailoiu, E; Brailoiu, GC; Deliu, E; Dun, NJ; Oprea, TI1
Chen, J; Cui, G; Feng, H; Hu, R; Hu, S; Li, F; Lin, J; Meng, H; Sun, H; Wan, Q; Wu, N; Zhang, Q1
Burnett, LA; Light, MM; Mehrotra, P; Nowak, RA1
Gui, Y; Li, D; Lin, W; Shi, Z; Tian, R; Wang, Y; Wang, Z; Zheng, XL; Zhu, Y1
Arterburn, JB; Brailoiu, E; Brailoiu, GC; Chitravanshi, VC; Oprea, TI1
Hao, Y; Kang, S; Li, D; Liu, A; Liu, Y; Sun, D; Sun, H; Xu, C; Yan, C; Zhou, C1
Chakrabarti, S; Davidge, ST1
Dacey, RG; Dietrich, HH; Murata, T; Xiang, C1
Buyukafsar, K; Kurt, AH1
Brunsing, RL; Owens, KS; Prossnitz, ER1
Chappell, MC; da Silva, AS; Lindsey, SH; Silva, MS1
Barhoumi, R; Han, G; Heaps, CL; Li, F; Meng, C; Stallone, JN; Szynkarski, CK; White, RE; Yu, X; Zhou, B1
Andò, S; Avena, P; Bartucci, M; Casaburi, I; Chimento, A; Dattilo, R; Patrizii, M; Pezzi, V; Sirianni, R1
Ignatov, A; Lattrich, C; Ortmann, O; Schüler, S; Skrzypczak, M; Treeck, O1
Angelone, T; Cerra, MC; De Francesco, EM; Maggiolini, M; Pasqua, T; Pupo, M1
Hellstrand, P; Holm, A; Leeb-Lundberg, LM; Nilsson, BO; Olde, B; Svensson, D1
Davis, JS; He, C; Hua, G; Lv, X; Tsai, MY; Wang, C1
Clark, SM; Hart, D; Lynn, T; Nilges, M; Patsos, O; Pollard, K; Shiel, C; Vasudevan, N1
Chappell, MC; Lindsey, SH; Liu, L1
Abonante, S; Maggiolini, M; Musti, AM; Pisano, A; Pupo, M1
Dohanich, GP; Grissom, EM; Hawley, WR; Moody, NM; Vasudevan, N1
Cao, X; Jiang, X; Liu, G; Liu, H; Wen, H; Yan, Y; Zhang, G1
Liu, M; Luo, H; Luo, S; Sun, Y; Tu, G; Wu, C; Yang, G; Yu, T1
Costa, SD; Ignatov, A; Ignatov, T; Poehlmann, A; Wege, AK; Weißenborn, C; Zenclussen, AC1
Costa, SD; Ignatov, A; Ignatov, T; Ignatova, Z; Ochel, HJ; Weißenborn, C; Zenclussen, AC1
Anchan, D; Clark, S; Pollard, K; Vasudevan, N1
Abonante, S; De Francesco, EM; Lappano, R; Maggiolini, M; Pellegrino, M; Ricchio, E; Santolla, MF1
Anchan, D; Gafur, A; Ogawa, S; Sano, K; Vasudevan, N1
Arán, VJ; Escario, JA; Gómez-Barrio, A; Ibáñez-Escribano, A; Marrero-Ponce, Y; Meneses-Marcel, A; Nogal-Ruiz, JJ1
Gao, J; Gui, Y; Li, D; Li, JJ; Shi, Z; Song, X; Tian, R; Walsh, MP; Wang, Z; Xu, C; Zheng, XL1
Chang, NC; Lee, TM; Lin, SZ1
Chen, J; Ho, SM; Jia, L; Lam, HM; Medvedovic, M; Ouyang, B; Vessella, RL; Wang, J; Wu, CL; Ying, J1
Li, Q; McAllister, CE; Mi, Z; Muma, NA; Mure, M1
Amann, K; Arterburn, JB; Barton, M; Daniel, C; Fredette, NC; Howard, TA; Hu, C; Meyer, MR; Prossnitz, ER; Ramesh, C1
Groban, L; Lin, M; Wang, H; Zhao, Z1
Ito, F; Kitawaki, J; Koshiba, A; Kusuki, I; Matsushima, H; Mori, T; Takaoka, O; Tanaka, Y1
Fan, S; Jiang, Z; Liao, Y; Liu, C; Tang, H; Wang, J; Xiong, J; Zhou, B; Zhou, S; Zou, M1
Hao, Q; Ji, XH; Wu, YZ; Zhang, Q; Zhang, YM1
Balassiano, E; Nezhat, CR1
He, YP; Qu, T; Xu, Q; Yu, LL; Yuan, DZ; Yue, LM; Zhang, JH; Zhang, SM1
Koganti, S1
Li, WL; Ping, Y; Xiang, W1
Choleris, E; Gabor, C; Lymer, J; Phan, A1
Chow, C; Duarte-Guterman, P; Galea, LA; Lieblich, SE1
Daniels, D; Santollo, J1
Amendola, D; Avena, P; Campana, C; Carpinelli, G; Casaburi, I; Cerquetti, L; Chimento, A; De Luca, A; Domanico, F; Fallo, F; Malivindi, R; Martire, E; Pezzi, V; Rizza, P; Sirianni, R; Stigliano, A; Zolea, F1
Abonante, S; Avino, S; Cirillo, F; De Francesco, EM; De Marco, P; Lappano, R; Maggiolini, M; Pellegrino, M; Rigiracciolo, DC; Santolla, MF; Scarpelli, A; Vivacqua, A1
Luch, A; Tarnow, P; Tralau, T1
Kadokawa, H; Rudolf, FO1
Clark, S; Pollard, K; Rainville, J; Vasudevan, N1
Bosnak, M; Celik, A; Inan, SY; Kurt, AH; Uremis, MM1
Cehan, N; KuKuruga, MA; Lafer, MM; Silberstein, E; Taylor, DR; Ulitzky, L1
Bello, M; Correa-Basurto, J; Méndez-Luna, D1
Budish, RA; Chappell, MC; Hutson, DD; Kashyap, S; Lindsey, SH; Liu, L; Miller, KS; Murphy, B; Trask, AJ; Trimmer, EH; Zimmerman, MA1
Boulware, MI; Frick, KM; Kim, J; Szinte, JS1
Ferguson, PL; Ralston-Hooper, KJ; Sabo-Attwood, T; Smith, LC1
Huang, Y; Shi, Y; Wei, D; Wu, C; Zhu, G1
Leitão, AJ; Mendes, AF; Ribeiro, M; Rufino, AT; Sousa, C1
Cheng, Q; Kang, WB; Liu, G; Meng, J; Tian, Z; Wang, XS; Zhang, K; Zhao, JN1
Chen, Z; Du, J; Jiang, G; Liang, S; Liu, Q; Su, Q; Wang, H; Wei, W; Zhou, Y1
Choleris, E; Lymer, J; Robinson, A; Winters, BD1
Bashashati, M; Fichna, J; Habibi, S; Sibaev, A; Storr, M; Timmermans, JP; Zielińska, M1
Davis, JS; Dong, J; He, C; Hua, G; Huang, C; Karpf, AR; Lv, X; Remmenga, SW; Rodabough, KJ; Wang, C; Wang, Z1
Han, G; Heaps, CL; Schwarz, BJ; Stallone, JN; Yu, X; Zhang, Q; Zhao, Y1
Chen, Z; Du, J; Huang, H; Jiang, G; Liu, H; Liu, Q; Wang, H; Yang, X; Zhou, Y1
Aires, RD; Bissoli, NS; Lemos, VS; Peixoto, P; Santos, RLD1
Giles, J; Terry, LE; Tran, QK; VerMeer, M1
Custódio, JBA; Ribeiro, MPC; Santos, AE1
Han, G; Heaps, CL; Stallone, JN; Yu, X1
Butler, MJ; Eckel, LA; Hildebrandt, RP1
Delp, MD; Evanson, KW; Ghosh, P; Goldsmith, JA1
Chen, XR; Han, QQ; Huang, HJ; Li, HY; Ma, SL; Wang, HM; Wang, J; Wang, YL; Yu, J; Yu, R1
Chen, X; Jin, Y; Wang, Z; Zhao, Y; Zheng, J1
Belfiore, A; Brunetti, G; Cirillo, F; Galli, GR; Lappano, R; Maggiolini, M; Miglietta, AM; Rigiracciolo, DC; Santolla, MF; Talia, M; Vivacqua, A1
Cho, HJ; Hwang, YS; Kim, JT; Kim, TW; Lee, HG; Lee, SJ; Park, GL1
Liang, S; Liu, ZC; Sun, L; Wang, D; Wang, Z; Yang, DQ; Yang, J; Zhao, ZY1
Ahmad, S; da Silva, JS; Ferrario, CM; Groban, L; Sudo, RT; Sun, X; Varagic, J; Wang, H; Zapata-Sudo, G1
Hartig, R; Haybaeck, J; Nass, N; Vo, DH; Weinert, S1
Feng, B; Hu, LN; Liu, SB; Lu, L; Wang, XS; Wang, YT; Yang, LK; Yue, J; Zhang, K1
Christian, D; Clayton, S; Giles, J; Tran, QK; Wauson, E; Whitcomb, V1
Gu, ZW; Hao, LY; Wang, YX1
Aiello, EA; Blanco, PG; Di Mattia, RA; Jaquenod De Giusti, C; Mariángelo, JIE; Mundiña-Weilenmann, C; Orlowski, A; Portiansky, EL1
Attaran, A; Chivers, DP; Naderi, M; Niyogi, S; Salahinejad, A1
Broughton, BRS; Chrissobolis, S; Diep, H; Dinh, QN; Drummond, GR; Judkins, CP; Kim, HA; Saini, N; Sobey, CG; Vinh, A1
Aceves, JO; Allan, JM; Daugherty, EM; De Miguel, C; Gohar, EY; Jin, C; Lindsey, SH; Obi, IE; Pollock, DM; Pollock, JS; Sedaka, R; Soliman, RH1
Ignatov, A; Ignatov, T; Ortmann, O; Schüler-Toprak, S; Skrzypczak, M; Treeck, O1
Almutlaq, RN; Butt, MK; Daugherty, EM; De Miguel, C; Gohar, EY; Jin, C; Pollock, DM; Pollock, JS1
Ahmad, S; Ferrario, CM; Groban, L; Hodge, H; Sun, X; Wang, H; Wright, KN1
Choi, CY; Han, EH; Hwang, YP; Jeong, HG; Jin, SW; Kim, CY; Kim, JY; Lee, GH; Park, JS; Pham, TH; Thai, TN1
Hirao-Suzuki, M; Nagase, K; Shigemori, E; Suemori, T; Sugihara, N; Takeda, S; Takiguchi, M; Tanaka, M; Tsutsumi, K; Yoshihara, S1
Bailly, Y; Dubois-Pot-Schneider, H; Dumond, H; Hirtz, A; Lebourdais, N; Rech, F; Smaïl-Tabbone, M; Vaginay, A1

Reviews

1 review(s) available for cyclopentane and 1-(4-(6-bromobenzo(1,3)dioxol-5-yl)-3a,4,5,9b-tetrahydro-3h-cyclopenta(c)quinolin-8-yl)ethanone

ArticleYear
Cardioprotective role of G-Protein Coupled Estrogen Receptor 1 (GPER1).
    Molecular membrane biology, 2015, Volume: 32, Issue:2

    Topics: Animals; Cardiotonic Agents; Cardiovascular Diseases; Cyclopentanes; ErbB Receptors; Gene Expression Regulation; Humans; Matrix Metalloproteinases; Quinolines; Receptor, Angiotensin, Type 1; Receptors, Estrogen; Receptors, G-Protein-Coupled

2015

Other Studies

125 other study(ies) available for cyclopentane and 1-(4-(6-bromobenzo(1,3)dioxol-5-yl)-3a,4,5,9b-tetrahydro-3h-cyclopenta(c)quinolin-8-yl)ethanone

ArticleYear
G protein-coupled receptor 30 (GPR30) mediates gene expression changes and growth response to 17beta-estradiol and selective GPR30 ligand G-1 in ovarian cancer cells.
    Cancer research, 2007, Feb-15, Volume: 67, Issue:4

    Topics: Animals; Breast Neoplasms; Cell Growth Processes; Cell Line, Tumor; Cyclopentanes; Estradiol; Estrogen Receptor alpha; Female; Gene Expression Regulation, Neoplastic; Genes, fos; Humans; Ovarian Neoplasms; Promoter Regions, Genetic; Proto-Oncogene Proteins c-fos; Quinolines; Receptors, Estrogen; Receptors, G-Protein-Coupled; RNA, Messenger; Signal Transduction

2007
Distribution and characterization of estrogen receptor G protein-coupled receptor 30 in the rat central nervous system.
    The Journal of endocrinology, 2007, Volume: 193, Issue:2

    Topics: Animals; Calcium; Cells, Cultured; Central Nervous System; Cyclopentanes; Cytosol; Female; Hippocampus; Hypothalamus; Immune Sera; Immunohistochemistry; Ligands; Male; Medulla Oblongata; Mesencephalon; Pituitary Gland; Prosencephalon; Quinolines; Rats; Rats, Sprague-Dawley; Receptors, G-Protein-Coupled

2007
GPR30 contributes to estrogen-induced thymic atrophy.
    Molecular endocrinology (Baltimore, Md.), 2008, Volume: 22, Issue:3

    Topics: Animals; Apoptosis; Atrophy; Cyclopentanes; Estradiol; Estrogen Receptor alpha; Estrogen Receptor beta; Female; Inbreeding; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; NF-kappa B; Quinolines; Receptors, G-Protein-Coupled; T-Lymphocytes; Thymus Gland

2008
GPR30 estrogen receptor agonists induce mechanical hyperalgesia in the rat.
    The European journal of neuroscience, 2008, Volume: 27, Issue:7

    Topics: Animals; Cells, Cultured; Cyclopentanes; Estradiol; Estrogen Receptor Modulators; Fulvestrant; Hyperalgesia; Male; Physical Stimulation; Protein Kinase C-epsilon; Quinolines; Rats; Rats, Sprague-Dawley; Receptors, G-Protein-Coupled

2008
Involvement of estradiol-17beta and its membrane receptor, G protein coupled receptor 30 (GPR30) in regulation of oocyte maturation in zebrafish, Danio rario.
    General and comparative endocrinology, 2009, Volume: 161, Issue:1

    Topics: Androstatrienes; Animals; Aromatase Inhibitors; Cyclopentanes; Estradiol; Female; Fulvestrant; Hydroxyprogesterones; Oocytes; Quinolines; Receptors, Estradiol; Receptors, G-Protein-Coupled; Tamoxifen; Zebrafish; Zebrafish Proteins

2009
Expression of estrogen receptor GPR30 in the rat spinal cord and in autonomic and sensory ganglia.
    Journal of neuroscience research, 2009, May-15, Volume: 87, Issue:7

    Topics: Animals; Brain Stem; Cells, Cultured; Chromaffin Cells; Cyclopentanes; Dose-Response Relationship, Drug; Female; Ganglia, Autonomic; Ganglia, Sensory; Gene Expression; Hippocampus; Hypothalamus; Male; Membrane Potentials; Neurons; Phenylethanolamine N-Methyltransferase; Quinolines; Rats; Rats, Sprague-Dawley; Receptors, G-Protein-Coupled; RNA, Messenger; Spinal Cord; Tyrosine 3-Monooxygenase

2009
Membrane estrogen receptor regulates experimental autoimmune encephalomyelitis through up-regulation of programmed death 1.
    Journal of immunology (Baltimore, Md. : 1950), 2009, Mar-01, Volume: 182, Issue:5

    Topics: Amino Acid Sequence; Animals; Antigens, Surface; Apoptosis Regulatory Proteins; Cells, Cultured; Cyclopentanes; Encephalomyelitis, Autoimmune, Experimental; Estradiol; Female; Membrane Proteins; Mice; Mice, Inbred C57BL; Mice, Knockout; Molecular Sequence Data; Programmed Cell Death 1 Receptor; Quinolines; Receptors, Estrogen; Receptors, G-Protein-Coupled; Signal Transduction; Up-Regulation

2009
Chronic treatment with the G protein-coupled receptor 30 agonist G-1 decreases blood pressure in ovariectomized mRen2.Lewis rats.
    Endocrinology, 2009, Volume: 150, Issue:8

    Topics: Angiotensin II; Animals; Aorta, Thoracic; Blood Pressure; Blotting, Western; Body Weight; Cyclopentanes; Female; Immunohistochemistry; In Vitro Techniques; Nitric Oxide; Organ Size; Ovariectomy; Polymerase Chain Reaction; Quinolines; Rats; Receptors, G-Protein-Coupled; Uterus; Vasoconstrictor Agents

2009
Chronic treatment with estrogen receptor agonists restores acquisition of a spatial learning task in young ovariectomized rats.
    Hormones and behavior, 2009, Volume: 56, Issue:3

    Topics: Animals; Cyclopentanes; Estradiol; Estrogen Receptor alpha; Estrogen Receptor beta; Female; Learning; Luteinizing Hormone; Maze Learning; Neuropsychological Tests; Nitriles; Ovariectomy; Phenols; Pyrazoles; Quinolines; Rats; Rats, Sprague-Dawley; Receptors, G-Protein-Coupled; Selective Estrogen Receptor Modulators; Space Perception; Time Factors

2009
Beneficial role of the GPR30 agonist G-1 in an animal model of multiple sclerosis.
    Journal of neuroimmunology, 2009, Sep-29, Volume: 214, Issue:1-2

    Topics: Adoptive Transfer; Animals; Cyclopentanes; Disease Models, Animal; Encephalomyelitis, Autoimmune, Experimental; Estrogen Receptor alpha; Estrogen Receptor beta; Humans; Immunohistochemistry; Interleukin-6; Macrophages; Mice; Mice, Inbred Strains; Microglia; Monocytes; Multiple Sclerosis; Quinolines; Rats; Receptors, Estrogen; Receptors, G-Protein-Coupled; Severity of Illness Index; T-Lymphocytes, Regulatory; Tumor Necrosis Factor-alpha

2009
Activation of a novel estrogen receptor, GPER, is cardioprotective in male and female rats.
    American journal of physiology. Heart and circulatory physiology, 2009, Volume: 297, Issue:5

    Topics: Androstadienes; Animals; Cardiotonic Agents; Cyclopentanes; Disease Models, Animal; Female; In Vitro Techniques; Male; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Myocardial Contraction; Myocardial Infarction; Myocardial Reperfusion Injury; Myocardium; Perfusion; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Quinolines; Rats; Rats, Sprague-Dawley; Receptors, Estrogen; Receptors, G-Protein-Coupled; Signal Transduction; Ventricular Function, Left; Ventricular Pressure; Wortmannin

2009
Endothelium-dependent relaxation by G protein-coupled receptor 30 agonists in rat carotid arteries.
    American journal of physiology. Heart and circulatory physiology, 2010, Volume: 298, Issue:3

    Topics: Animals; Carotid Arteries; Cyclopentanes; Endothelium, Vascular; Female; Male; Models, Animal; NADP; Nitric Oxide; Quinolines; Rats; Rats, Sprague-Dawley; Receptors, G-Protein-Coupled; Superoxides; Vasodilation

2010
The G protein-coupled receptor GPR30 inhibits proliferation of estrogen receptor-positive breast cancer cells.
    Cancer research, 2010, Feb-01, Volume: 70, Issue:3

    Topics: Breast Neoplasms; Calcium; Cell Line, Tumor; Cell Proliferation; Cyclin-Dependent Kinase Inhibitor p21; Cyclopentanes; Diethylstilbestrol; Estradiol; Estrogen Receptor alpha; Estrogens; Female; Flow Cytometry; G1 Phase; Gene Expression Regulation, Neoplastic; Humans; Immunoblotting; Quinolines; Receptors, Estrogen; Receptors, G-Protein-Coupled; Reverse Transcriptase Polymerase Chain Reaction; RNA Interference; Signal Transduction; Tumor Suppressor Protein p53

2010
Activation of GPR30 inhibits the growth of prostate cancer cells through sustained activation of Erk1/2, c-jun/c-fos-dependent upregulation of p21, and induction of G(2) cell-cycle arrest.
    Cell death and differentiation, 2010, Volume: 17, Issue:9

    Topics: Animals; Antineoplastic Agents; Cell Cycle; Cell Line, Tumor; Cell Nucleus; Cell Proliferation; Cyclin-Dependent Kinase Inhibitor p21; Cyclopentanes; Extracellular Signal-Regulated MAP Kinases; Flavonoids; G2 Phase; Gene Expression; Humans; Male; Mice; Mice, Nude; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Phosphorylation; Prostatic Neoplasms; Protein Kinase Inhibitors; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-fos; Proto-Oncogene Proteins c-jun; Quinolines; Receptors, Estrogen; Receptors, G-Protein-Coupled; RNA, Small Interfering; Signal Transduction; Xenograft Model Antitumor Assays

2010
Regulation of ERRalpha gene expression by estrogen receptor agonists and antagonists in SKBR3 breast cancer cells: differential molecular mechanisms mediated by g protein-coupled receptor GPR30/GPER-1.
    Molecular endocrinology (Baltimore, Md.), 2010, Volume: 24, Issue:5

    Topics: Acetylation; Blotting, Western; Breast Neoplasms; Cell Line, Tumor; Chromatin Immunoprecipitation; Cyclopentanes; ERRalpha Estrogen-Related Receptor; Estradiol; Fulvestrant; Gene Expression; Histones; Humans; Polymerase Chain Reaction; Promoter Regions, Genetic; Protein Transport; Quinolines; Receptors, Estrogen; Receptors, G-Protein-Coupled; RNA Interference; Tamoxifen

2010
Highly efficient synthesis and characterization of the GPR30-selective agonist G-1 and related tetrahydroquinoline analogs.
    Organic & biomolecular chemistry, 2010, May-07, Volume: 8, Issue:9

    Topics: Cyclopentanes; Molecular Structure; Quinolines; Receptors, G-Protein-Coupled; Stereoisomerism; Structure-Activity Relationship

2010
Signaling via GPR30 protects the myocardium from ischemia/reperfusion injury.
    Surgery, 2010, Volume: 148, Issue:2

    Topics: Animals; Cyclopentanes; Estrogens; Heart; In Vitro Techniques; Inflammation Mediators; Interleukin-1beta; Interleukin-6; Male; Myocardial Reperfusion Injury; Myocardium; Quinolines; Rats; Rats, Sprague-Dawley; Receptors, G-Protein-Coupled; Signal Transduction; Tumor Necrosis Factor-alpha

2010
Expression and signaling of G protein-coupled estrogen receptor 1 (GPER) in rat sertoli cells.
    Biology of reproduction, 2010, Aug-01, Volume: 83, Issue:2

    Topics: Animals; Apoptosis; Cells, Cultured; Cyclopentanes; Enzyme Activation; ErbB Receptors; Estradiol; Estrogen Receptor alpha; Fulvestrant; Gene Expression Regulation; Male; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Phosphorylation; Quinolines; Rats; Rats, Wistar; Receptors, G-Protein-Coupled; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sertoli Cells; Signal Transduction; Testis

2010
Dilation of epicardial coronary arteries by the G protein-coupled estrogen receptor agonists G-1 and ICI 182,780.
    Pharmacology, 2010, Volume: 86, Issue:1

    Topics: Animals; Coronary Vessels; Cyclopentanes; Endothelin-1; Estradiol; Estrogen Receptor alpha; Estrogen Receptor beta; Fulvestrant; In Vitro Techniques; Pericardium; Quinolines; Receptors, G-Protein-Coupled; Serotonin; Swine; Vasodilation

2010
GPR30 co-localizes with cholinergic neurons in the basal forebrain and enhances potassium-stimulated acetylcholine release in the hippocampus.
    Psychoneuroendocrinology, 2011, Volume: 36, Issue:2

    Topics: Acetylcholine; Animals; Cholinergic Fibers; Cyclopentanes; Estradiol; Female; Gene Expression; Hippocampus; Models, Biological; Neurons; Potassium; Prosencephalon; Quinolines; Rats; Rats, Sprague-Dawley; Receptors, G-Protein-Coupled; Tissue Distribution

2011
Attenuation of salt-induced cardiac remodeling and diastolic dysfunction by the GPER agonist G-1 in female mRen2.Lewis rats.
    PloS one, 2010, Nov-03, Volume: 5, Issue:11

    Topics: Animals; Blood Pressure; Cardiomegaly; Cyclopentanes; Diastole; Echocardiography; Female; Heart; Hypertension; Immunohistochemistry; Mice; Myocardium; Quinolines; Rats; Rats, Inbred Lew; Rats, Transgenic; Receptors, G-Protein-Coupled; Renin; Reverse Transcriptase Polymerase Chain Reaction; Sodium Chloride, Dietary

2010
The GPER1 agonist G-1 attenuates endothelial cell proliferation by inhibiting DNA synthesis and accumulating cells in the S and G2 phases of the cell cycle.
    Journal of vascular research, 2011, Volume: 48, Issue:4

    Topics: Animals; Cell Proliferation; Cells, Cultured; Chlorocebus aethiops; COS Cells; Cyclopentanes; DNA; Endothelial Cells; G2 Phase; Humans; Mice; Quinolines; Receptors, Estrogen; Receptors, G-Protein-Coupled; S Phase

2011
GPR30 activation opposes estrogen-dependent uterine growth via inhibition of stromal ERK1/2 and estrogen receptor alpha (ERα) phosphorylation signals.
    Endocrinology, 2011, Volume: 152, Issue:4

    Topics: Animals; Blotting, Northern; Blotting, Western; Cyclopentanes; Estrogen Receptor alpha; Estrogens; Female; Immunohistochemistry; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Ovariectomy; Phosphorylation; Quinolines; Receptors, Estrogen; Receptors, G-Protein-Coupled; Uterus

2011
Vasodilation in response to the GPR30 agonist G-1 is not different from estradiol in the mRen2.Lewis female rat.
    Journal of cardiovascular pharmacology, 2011, Volume: 57, Issue:5

    Topics: Animals; Aorta; Blood Pressure; Cyclopentanes; Endothelial Cells; Endothelium, Vascular; Estradiol; Female; Hypertension; Immunohistochemistry; In Vitro Techniques; Mesenteric Arteries; Muscle, Smooth, Vascular; Ovariectomy; Quinolines; Rats; Rats, Inbred Lew; Receptors, G-Protein-Coupled; Vascular Resistance; Vasodilation

2011
Estrogen destabilizes microtubules through an ion-conductivity-independent TRPV1 pathway.
    Journal of neurochemistry, 2011, Volume: 117, Issue:6

    Topics: Animals; Binding, Competitive; Cell Line; Cyclopentanes; Estradiol; Estrogens; Ganglia, Spinal; Gene Knockdown Techniques; Ion Channel Gating; Ligands; Male; Microtubules; Models, Molecular; Neurons; Pain; Phosphorylation; Protein Binding; Protein Kinase C-epsilon; Pseudopodia; Quinolines; Rats; Rats, Sprague-Dawley; Receptors, G-Protein-Coupled; Signal Transduction; TRPV Cation Channels; Tubulin

2011
Insulinotropic and antidiabetic effects of 17β-estradiol and the GPR30 agonist G-1 on human pancreatic islets.
    Endocrinology, 2011, Volume: 152, Issue:7

    Topics: Apoptosis; Cell Survival; Cyclopentanes; Diabetes Mellitus, Type 2; Estradiol; Estrogen Antagonists; Female; Gene Expression Regulation; Humans; Hyperglycemia; Hypoglycemic Agents; Insulin; Insulin Secretion; Islets of Langerhans; Male; Molecular Targeted Therapy; Oligonucleotide Array Sequence Analysis; Organ Culture Techniques; Quinolines; Receptors, Estrogen; Receptors, G-Protein-Coupled; RNA, Messenger; Second Messenger Systems; Sex Characteristics

2011
Mechanisms of estradiol-induced insulin secretion by the G protein-coupled estrogen receptor GPR30/GPER in pancreatic beta-cells.
    Endocrinology, 2011, Volume: 152, Issue:8

    Topics: Amino Acid Sequence; Animals; Calcium; Cell Line, Tumor; Chlorocebus aethiops; COS Cells; Cyclopentanes; Estradiol; Extracellular Signal-Regulated MAP Kinases; Female; Insulin; Insulin Secretion; Insulin-Secreting Cells; Mice; Mice, Inbred C57BL; Molecular Sequence Data; Phosphatidylinositol 3-Kinases; Quinolines; Receptors, Estrogen; Receptors, G-Protein-Coupled

2011
Induction of interleukin-10 in the T helper type 17 effector population by the G protein coupled estrogen receptor (GPER) agonist G-1.
    Immunology, 2011, Volume: 134, Issue:1

    Topics: Animals; CD4-Positive T-Lymphocytes; Cell Proliferation; Cyclopentanes; Extracellular Signal-Regulated MAP Kinases; Forkhead Transcription Factors; Green Fluorescent Proteins; Interferon-gamma; Interleukin-10; Interleukin-17; Interleukin-23; Interleukin-6; Lymphocyte Activation; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Nuclear Receptor Subfamily 1, Group F, Member 3; Quinolines; Receptors, Estrogen; Receptors, G-Protein-Coupled; Signal Transduction; Spleen; T-Lymphocyte Subsets; T-Lymphocytes; Th17 Cells; Transforming Growth Factor beta; Tumor Necrosis Factor-alpha

2011
Estrogen receptor GPR30 reduces oxidative stress and proteinuria in the salt-sensitive female mRen2.Lewis rat.
    Hypertension (Dallas, Tex. : 1979), 2011, Volume: 58, Issue:4

    Topics: Animals; Blood Pressure; Cyclopentanes; Estradiol; Female; Kidney Tubules, Proximal; Low Density Lipoprotein Receptor-Related Protein-2; Mesenteric Arteries; Models, Animal; Oxidative Stress; Proteinuria; Quinolines; Rats; Rats, Inbred Lew; Receptors, G-Protein-Coupled; Renin; Salt Tolerance; Sodium, Dietary; Vasodilation

2011
G protein-coupled estrogen receptor 1-mediated effects in the rat myometrium.
    American journal of physiology. Cell physiology, 2011, Volume: 301, Issue:5

    Topics: Animals; Benzodioxoles; Calcium; Calcium Channel Blockers; Cyclopentanes; Enzyme Inhibitors; Female; Membrane Potentials; Myometrium; Nifedipine; Quinolines; Rats; Rats, Sprague-Dawley; Receptors, G-Protein-Coupled; Thapsigargin; Uterine Contraction

2011
Aberrant ligand-induced activation of G protein-coupled estrogen receptor 1 (GPER) results in developmental malformations during vertebrate embryogenesis.
    Toxicological sciences : an official journal of the Society of Toxicology, 2012, Volume: 125, Issue:1

    Topics: Abnormalities, Multiple; Animals; Benzodioxoles; Calcium; Cyclopentanes; Dose-Response Relationship, Drug; Embryo, Nonmammalian; Embryonic Development; Female; In Situ Hybridization; Ligands; Male; Muscles; Quinolines; Receptors, G-Protein-Coupled; Somites; Zebrafish; Zebrafish Proteins

2012
Activation of the G-protein-coupled receptor GPR30 induces anxiogenic effects in mice, similar to oestradiol.
    Psychopharmacology, 2012, Volume: 221, Issue:3

    Topics: Animals; Anxiety; Behavior, Animal; Cyclopentanes; Estradiol; Estrogen Receptor alpha; Estrogen Receptor beta; Estrous Cycle; Female; Male; Mice; Mice, Inbred C57BL; Ovariectomy; Quinolines; Receptors, Estrogen; Receptors, G-Protein-Coupled; Sex Factors

2012
Activation of GPR30 attenuates diastolic dysfunction and left ventricle remodelling in oophorectomized mRen2.Lewis rats.
    Cardiovascular research, 2012, Apr-01, Volume: 94, Issue:1

    Topics: Angiotensin II; Animals; Atrial Natriuretic Factor; Blood Pressure; Calcium; Cardiotonic Agents; Cell Line; Collagen; Cyclopentanes; Echocardiography, Doppler; Estrogens; Female; Gene Expression Regulation; Genotype; Hypertrophy, Left Ventricular; Injections, Subcutaneous; Mice; Myocytes, Cardiac; NADPH Oxidase 4; NADPH Oxidases; Natriuretic Peptide, Brain; Ovariectomy; Phenotype; Quinolines; Rats; Rats, Inbred Lew; Rats, Transgenic; Receptors, G-Protein-Coupled; Renin; RNA, Messenger; Time Factors; Ventricular Dysfunction, Left; Ventricular Function, Left; Ventricular Remodeling

2012
The G protein-coupled oestrogen receptor 1 agonist G-1 disrupts endothelial cell microtubule structure in a receptor-independent manner.
    Molecular and cellular biochemistry, 2012, Volume: 366, Issue:1-2

    Topics: Animals; Aorta; Cell Proliferation; Cells, Cultured; Cyclopentanes; DNA-Directed DNA Polymerase; Endothelial Cells; Female; Gene Expression; Humans; Kinetics; Mice; Mice, Inbred C57BL; Mice, Knockout; Microtubules; Myocytes, Smooth Muscle; Protein Multimerization; Quinolines; Receptors, Estrogen; Receptors, G-Protein-Coupled; Tissue Culture Techniques; Tubulin Modulators; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factor Receptor-1; Vascular Endothelial Growth Factor Receptor-2

2012
Effects of a combined treatment with GPR30 agonist G-1 and herceptin on growth and gene expression of human breast cancer cell lines.
    Cancer investigation, 2012, Volume: 30, Issue:5

    Topics: Antibodies, Monoclonal, Humanized; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Cyclopentanes; Dose-Response Relationship, Drug; Female; Gene Expression Regulation; Genes, fos; Humans; Quinolines; Receptors, Estrogen; Receptors, G-Protein-Coupled; Trastuzumab

2012
Mechanisms of G protein-coupled estrogen receptor-mediated spinal nociception.
    The journal of pain, 2012, Volume: 13, Issue:8

    Topics: Action Potentials; Analgesics, Opioid; Animals; Animals, Newborn; Behavior, Animal; Benzodioxoles; Calcium; Cells, Cultured; Cyclopentanes; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Interactions; Female; Gene Expression Regulation; In Vitro Techniques; Male; Mice; Mice, Inbred ICR; Microinjections; Morphine; Neurons; Nociception; Nociceptive Pain; Pain Measurement; Patch-Clamp Techniques; Quinolines; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Receptors, Estrogen; Receptors, G-Protein-Coupled; Spinal Cord; Superoxides

2012
G-protein coupled estrogen receptor 1 mediated estrogenic neuroprotection against spinal cord injury.
    Critical care medicine, 2012, Volume: 40, Issue:12

    Topics: Animals; Cyclopentanes; Estradiol; Estrogen Antagonists; Estrogen Receptor alpha; Fulvestrant; Immunohistochemistry; Male; Neuroprotective Agents; Quinolines; Rats; Rats, Sprague-Dawley; Receptors, G-Protein-Coupled; Spinal Cord; Spinal Cord Injuries

2012
Stimulation of GPR30 increases release of EMMPRIN-containing microvesicles in human uterine epithelial cells.
    The Journal of clinical endocrinology and metabolism, 2012, Volume: 97, Issue:12

    Topics: Basigin; Benzodioxoles; Cell Line, Transformed; Cholera Toxin; Cyclopentanes; Cytoplasmic Vesicles; Epithelial Cells; Estradiol; Female; Humans; Protein Isoforms; Quinolines; Receptors, Estrogen; Receptors, G-Protein-Coupled; Stimulation, Chemical; Telomerase; Uterus

2012
Differential expression of G-protein-coupled estrogen receptor-30 in human myometrial and uterine leiomyoma smooth muscle.
    Fertility and sterility, 2013, Volume: 99, Issue:1

    Topics: Adult; Cells, Cultured; Cyclopentanes; Estradiol; Female; Flavonoids; Humans; Leiomyoma; Middle Aged; Muscle, Smooth; Myometrium; Quinolines; Receptors, Estrogen; Receptors, G-Protein-Coupled; RNA, Messenger; Transcriptome; Uterine Neoplasms

2013
Bradycardic effects mediated by activation of G protein-coupled estrogen receptor in rat nucleus ambiguus.
    Experimental physiology, 2013, Volume: 98, Issue:3

    Topics: Animals; Bradycardia; Calcium; Cyclopentanes; Heart; Male; Medulla Oblongata; Membrane Potentials; Parasympathetic Nervous System; Quinolines; Rats; Rats, Wistar; Receptors, Estrogen; Receptors, G-Protein-Coupled; Vagus Nerve

2013
Chronic activation of the G protein-coupled receptor 30 with agonist G-1 attenuates heart failure.
    PloS one, 2012, Volume: 7, Issue:10

    Topics: Animals; Cyclopentanes; Estrogens; Female; Heart Failure; Isoproterenol; Natriuretic Peptide, Brain; Ovariectomy; Quinolines; Rats; Rats, Sprague-Dawley; Receptors, G-Protein-Coupled

2012
G-protein coupled receptor 30 (GPR30): a novel regulator of endothelial inflammation.
    PloS one, 2012, Volume: 7, Issue:12

    Topics: Anti-Inflammatory Agents; Cell Nucleus; Cyclopentanes; Endothelium, Vascular; Estradiol; Human Umbilical Vein Endothelial Cells; Humans; Inflammation; Intercellular Adhesion Molecule-1; NF-kappa B; Quinolines; Receptors, Estrogen; Receptors, G-Protein-Coupled; Tamoxifen; Tumor Necrosis Factor-alpha; Vascular Cell Adhesion Molecule-1

2012
G protein-coupled estrogen receptor agonist improves cerebral microvascular function after hypoxia/reoxygenation injury in male and female rats.
    Stroke, 2013, Volume: 44, Issue:3

    Topics: Animals; Benzodioxoles; Brain; Cerebrovascular Circulation; Cyclopentanes; Estrogens; Female; Male; Microvessels; Models, Animal; Quinolines; Rats; Rats, Inbred Lew; Receptors, G-Protein-Coupled; Reperfusion Injury; Sex Factors; Signal Transduction; Vasodilation

2013
Vasoconstriction induced by G1, a G-protein-coupled oestrogen receptor1 (GPER-1) agonist, in the isolated perfused rat kidney.
    European journal of pharmacology, 2013, Feb-28, Volume: 702, Issue:1-3

    Topics: Animals; Calcium Channel Blockers; Calcium Channels; Cyclopentanes; Estradiol; Estrogen Antagonists; Estrogens; Fulvestrant; In Vitro Techniques; Kidney; Male; Protein Kinase Inhibitors; Protein Kinases; Quinolines; Rats; Rats, Wistar; Receptors, G-Protein-Coupled; Vasoconstriction

2013
The G protein-coupled estrogen receptor (GPER) agonist G-1 expands the regulatory T-cell population under TH17-polarizing conditions.
    Journal of immunotherapy (Hagerstown, Md. : 1997), 2013, Volume: 36, Issue:3

    Topics: Animals; Cell Differentiation; Cells, Cultured; Cyclopentanes; Encephalomyelitis, Autoimmune, Experimental; Forkhead Transcription Factors; Lymphocyte Activation; Mice; Mice, Inbred C57BL; Quinolines; Receptors, Estrogen; Receptors, G-Protein-Coupled; RNA, Messenger; T-Lymphocytes, Regulatory; Th17 Cells

2013
Reduced vasorelaxation to estradiol and G-1 in aged female and adult male rats is associated with GPR30 downregulation.
    American journal of physiology. Endocrinology and metabolism, 2013, Jul-01, Volume: 305, Issue:1

    Topics: Aging; Animals; Blood Pressure; Cyclopentanes; Down-Regulation; Estradiol; Female; Hypertension; Male; Mesenteric Arteries; Ovariectomy; Quinolines; Rats; Rats, Inbred Lew; Rats, Transgenic; Receptors, G-Protein-Coupled; Renin; Sex Characteristics; Vasodilation

2013
Activation of GPER Induces Differentiation and Inhibition of Coronary Artery Smooth Muscle Cell Proliferation.
    PloS one, 2013, Volume: 8, Issue:6

    Topics: Animals; Cell Differentiation; Cell Proliferation; Cells, Cultured; Coronary Vessels; Cyclopentanes; Down-Regulation; Humans; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Quinolines; Receptors, Estrogen; Receptors, G-Protein-Coupled; Swine; Up-Regulation

2013
Selective GPER activation decreases proliferation and activates apoptosis in tumor Leydig cells.
    Cell death & disease, 2013, Aug-01, Volume: 4

    Topics: Animals; Antineoplastic Agents, Hormonal; Apoptosis; Cell Line, Tumor; Cell Nucleus Shape; Cell Proliferation; Cyclopentanes; DNA Damage; Estradiol; Extracellular Signal-Regulated MAP Kinases; Gene Expression; Leydig Cell Tumor; Male; MAP Kinase Signaling System; Mice; Mice, Nude; Quinolines; Rats; Receptors, G-Protein-Coupled; Testicular Neoplasms; Testis; Xenograft Model Antitumor Assays

2013
G protein-coupled estrogen receptor (GPER) expression in endometrial adenocarcinoma and effect of agonist G-1 on growth of endometrial adenocarcinoma cell lines.
    Steroids, 2013, Volume: 78, Issue:11

    Topics: Adenocarcinoma; Adult; Cell Line, Tumor; Cell Proliferation; Cyclopentanes; Endometrial Neoplasms; Endometrium; Estrogen Receptor alpha; Female; Gene Expression Regulation, Neoplastic; Humans; Membrane Proteins; Middle Aged; PTEN Phosphohydrolase; Quinolines; Receptors, Estrogen; Receptors, G-Protein-Coupled; Receptors, Progesterone; RNA, Messenger

2013
GPER mediates cardiotropic effects in spontaneously hypertensive rat hearts.
    PloS one, 2013, Volume: 8, Issue:8

    Topics: Animals; Benzodioxoles; Cardiovascular Agents; Connective Tissue Growth Factor; Cyclopentanes; Gene Expression Regulation; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Heart; Hypertension; Hypoxia-Inducible Factor 1, alpha Subunit; JNK Mitogen-Activated Protein Kinases; Male; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Muscle Relaxation; Nitric Oxide Synthase Type III; Organ Culture Techniques; Ornithine; Proto-Oncogene Proteins c-akt; Quinolines; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Receptors, G-Protein-Coupled; Signal Transduction

2013
The G protein-coupled estrogen receptor 1 (GPER1/GPR30) agonist G-1 regulates vascular smooth muscle cell Ca²⁺ handling.
    Journal of vascular research, 2013, Volume: 50, Issue:5

    Topics: Animals; Benzodioxoles; Calcium; Cell Line; Cyclopentanes; Estradiol; Estrogen Receptor alpha; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Nifedipine; Quinolines; Rats; Receptors, G-Protein-Coupled

2013
The G-protein-coupled estrogen receptor agonist G-1 suppresses proliferation of ovarian cancer cells by blocking tubulin polymerization.
    Cell death & disease, 2013, Oct-17, Volume: 4

    Topics: Animals; Apoptosis; Cell Line, Tumor; Cell Proliferation; Cyclopentanes; Female; Humans; Ovarian Neoplasms; Polymerization; Prophase; Quinolines; Receptors, Estrogen; Receptors, G-Protein-Coupled; Spindle Apparatus; Sus scrofa; Tubulin

2013
Activation of the G-protein coupled receptor 30 (GPR30) has different effects on anxiety in male and female mice.
    Steroids, 2014, Volume: 81

    Topics: Animals; Anxiety; Corticosterone; Cyclopentanes; Estradiol; Estrogen Receptor alpha; Extracellular Signal-Regulated MAP Kinases; Female; Hippocampus; Male; Mice; Mice, Inbred C57BL; Orchiectomy; Ovariectomy; Phosphorylation; Quinolines; Receptors, Estrogen; Receptors, G-Protein-Coupled; Sex Factors; Signal Transduction

2014
Vasodilation by GPER in mesenteric arteries involves both endothelial nitric oxide and smooth muscle cAMP signaling.
    Steroids, 2014, Volume: 81

    Topics: Animals; Cyclic AMP; Cyclopentanes; Dose-Response Relationship, Drug; Endothelium, Vascular; Estradiol; Female; In Vitro Techniques; Mesenteric Arteries; Muscle, Smooth, Vascular; NG-Nitroarginine Methyl Ester; Nitric Oxide; Quinolines; Rats; Rats, Inbred Lew; Receptors, G-Protein-Coupled; Signal Transduction; Vasodilation

2014
GPER activates Notch signaling in breast cancer cells and cancer-associated fibroblasts (CAFs).
    The international journal of biochemistry & cell biology, 2014, Volume: 46

    Topics: Breast Neoplasms; Cell Line, Tumor; Cyclopentanes; Estradiol; Female; Fibroblasts; Gene Expression Regulation, Neoplastic; Humans; MCF-7 Cells; Quinolines; Receptor Cross-Talk; Receptors, Estrogen; Receptors, G-Protein-Coupled; Receptors, Notch; Signal Transduction; Up-Regulation

2014
Activation of G-protein-coupled receptor 30 is sufficient to enhance spatial recognition memory in ovariectomized rats.
    Behavioural brain research, 2014, Apr-01, Volume: 262

    Topics: Animals; Cyclopentanes; Estradiol; Female; Memory; Ovariectomy; Pattern Recognition, Visual; Quinolines; Rats; Rats, Long-Evans; Receptors, G-Protein-Coupled; Space Perception

2014
A novel estrogen receptor GPER mediates proliferation induced by 17β-estradiol and selective GPER agonist G-1 in estrogen receptor α (ERα)-negative ovarian cancer cells.
    Cell biology international, 2014, Volume: 38, Issue:5

    Topics: Cell Line, Tumor; Cell Proliferation; Cyclopentanes; Estradiol; Estrogen Receptor alpha; Female; Humans; Ovarian Neoplasms; Quinolines; Receptors, Estrogen; Receptors, G-Protein-Coupled

2014
GPER-mediated proliferation and estradiol production in breast cancer-associated fibroblasts.
    Endocrine-related cancer, 2014, Volume: 21, Issue:2

    Topics: Breast Neoplasms; Cell Cycle; Cell Proliferation; Cells, Cultured; Cyclopentanes; Estradiol; Female; Fibroblasts; Humans; Quinolines; Receptors, Estrogen; Receptors, G-Protein-Coupled; Tamoxifen

2014
GPER functions as a tumor suppressor in MCF-7 and SK-BR-3 breast cancer cells.
    Journal of cancer research and clinical oncology, 2014, Volume: 140, Issue:4

    Topics: Apoptosis; Blotting, Western; Breast Neoplasms; Cell Cycle Checkpoints; Cell Proliferation; Cyclopentanes; DNA Methylation; Female; Humans; Immunoenzyme Techniques; Promoter Regions, Genetic; Quinolines; Real-Time Polymerase Chain Reaction; Receptors, Estrogen; Receptors, G-Protein-Coupled; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Tumor Cells, Cultured

2014
GPER functions as a tumor suppressor in triple-negative breast cancer cells.
    Journal of cancer research and clinical oncology, 2014, Volume: 140, Issue:5

    Topics: Apoptosis; Carcinogenesis; Caspase 3; Cell Cycle Checkpoints; Cell Line, Tumor; Cell Proliferation; Cyclopentanes; Female; G2 Phase Cell Cycle Checkpoints; Gene Expression Regulation, Neoplastic; Humans; Quinolines; Receptors, Estrogen; Receptors, G-Protein-Coupled; RNA, Small Interfering; Triple Negative Breast Neoplasms

2014
GPR30 activation decreases anxiety in the open field test but not in the elevated plus maze test in female mice.
    Brain and behavior, 2014, Volume: 4, Issue:1

    Topics: Animals; Anti-Anxiety Agents; Anxiety; Behavior, Animal; Cyclopentanes; Female; Hippocampus; MAP Kinase Signaling System; Maze Learning; Mice; Mice, Inbred C57BL; Ovariectomy; Quinolines; Receptors, Estrogen; Receptors, G-Protein-Coupled

2014
GPER mediates activation of HIF1α/VEGF signaling by estrogens.
    Cancer research, 2014, Aug-01, Volume: 74, Issue:15

    Topics: Animals; Breast Neoplasms; Cell Growth Processes; Cell Line, Tumor; Cyclopentanes; Estradiol; Estrogens; Female; Heterografts; Human Umbilical Vein Endothelial Cells; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Mice; Mice, Nude; Quinolines; Receptors, Estrogen; Receptors, G-Protein-Coupled; Signal Transduction; Up-Regulation; Vascular Endothelial Growth Factor A

2014
Activation of the GPR30 receptor promotes lordosis in female mice.
    Neuroendocrinology, 2014, Volume: 100, Issue:1

    Topics: Animals; Cyclopentanes; Estradiol; Estrogens; Female; Mice, Inbred C57BL; Posture; Progesterone; Progestins; Quinolines; Random Allocation; Receptors, Estrogen; Receptors, G-Protein-Coupled; Reproductive Control Agents; Sexual Behavior, Animal

2014
A sequential procedure for rapid and accurate identification of putative trichomonacidal agents.
    Journal of microbiological methods, 2014, Volume: 105

    Topics: Animals; Antiprotozoal Agents; Computational Biology; Cyclopentanes; Dimetridazole; Disease Models, Animal; Drug Evaluation, Preclinical; Female; Mice; Parasitic Sensitivity Tests; Quantitative Structure-Activity Relationship; Quinolines; Rats, Wistar; Time Factors; Trichomonas Infections; Trichomonas vaginalis

2014
The GPER agonist G-1 induces mitotic arrest and apoptosis in human vascular smooth muscle cells independent of GPER.
    Journal of cellular physiology, 2015, Volume: 230, Issue:4

    Topics: Apoptosis; Cell Proliferation; Cells, Cultured; Cyclopentanes; Estrogens; Humans; Mitosis; Muscle, Smooth, Vascular; Phosphorylation; Quinolines; Receptors, Estrogen; Receptors, G-Protein-Coupled; Signal Transduction

2015
Both GPER and membrane oestrogen receptor-α activation protect ventricular remodelling in 17β oestradiol-treated ovariectomized infarcted rats.
    Journal of cellular and molecular medicine, 2014, Volume: 18, Issue:12

    Topics: Animals; Blotting, Western; Cyclopentanes; Estradiol; Estrogen Receptor alpha; Estrogens; Female; Ginsenosides; Membrane Proteins; Myocardial Infarction; Nitric Oxide Synthase Type III; Ovariectomy; Phosphatidylinositol 3-Kinases; Phosphorylation; Proto-Oncogene Proteins c-akt; Quinolines; Random Allocation; Rats, Wistar; Receptors, G-Protein-Coupled; Sapogenins; Signal Transduction; Ventricular Remodeling

2014
Targeting GPR30 with G-1: a new therapeutic target for castration-resistant prostate cancer.
    Endocrine-related cancer, 2014, Volume: 21, Issue:6

    Topics: Androgens; Animals; Biomarkers, Tumor; Blotting, Western; Cell Proliferation; Chromatin Immunoprecipitation; Cohort Studies; Cyclopentanes; Follow-Up Studies; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Humans; Immunoenzyme Techniques; Male; Mice; Neoplasm Metastasis; Neoplasm Staging; Prognosis; Prostatic Neoplasms, Castration-Resistant; Quinolines; Real-Time Polymerase Chain Reaction; Receptors, Androgen; Receptors, Estrogen; Receptors, G-Protein-Coupled; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; RNA, Small Interfering; Tumor Cells, Cultured; Xenograft Model Antitumor Assays

2014
GPER1 stimulation alters posttranslational modification of RGSz1 and induces desensitization of 5-HT1A receptor signaling in the rat hypothalamus.
    Neuroendocrinology, 2014, Volume: 100, Issue:2-3

    Topics: Animals; Cell Membrane; Central Nervous System Agents; Cyclopentanes; Estradiol; Estrogens; Female; Glycosylation; Hypothalamus; Organelles; Phosphorylation; Protein Isoforms; Protein Processing, Post-Translational; Quinolines; Random Allocation; Rats, Sprague-Dawley; Receptor, Serotonin, 5-HT1A; Receptors, G-Protein-Coupled; RGS Proteins; Signal Transduction; Sumoylation

2014
G protein-coupled estrogen receptor protects from atherosclerosis.
    Scientific reports, 2014, Dec-23, Volume: 4

    Topics: Animals; Atherosclerosis; Cholesterol, LDL; Cyclopentanes; Endothelial Cells; Female; Humans; Intracellular Membranes; Mice; Mice, Knockout; Nitric Oxide; Postmenopause; Quinolines; Receptors, Estrogen; Receptors, G-Protein-Coupled

2014
GPR30 decreases cardiac chymase/angiotensin II by inhibiting local mast cell number.
    Biochemical and biophysical research communications, 2015, Mar-27, Volume: 459, Issue:1

    Topics: Angiotensin II; Animals; CDC2 Protein Kinase; Cell Line; Cell Proliferation; Chymases; Cyclin-Dependent Kinases; Cyclopentanes; Estradiol; Estrogen Receptor Antagonists; Estrogens; Female; Mast Cells; Myocardium; Ovariectomy; Quinolines; Rats, Inbred Lew; Receptors, G-Protein-Coupled

2015
G protein-coupled estrogen receptor 1 agonist G-1 induces cell cycle arrest in the mitotic phase, leading to apoptosis in endometriosis.
    Fertility and sterility, 2015, Volume: 103, Issue:5

    Topics: Adult; Apoptosis; Caspase 3; Cell Proliferation; Cells, Cultured; Cyclopentanes; Dose-Response Relationship, Drug; Endometriosis; Female; Humans; M Phase Cell Cycle Checkpoints; Microtubules; Middle Aged; Ovarian Cysts; Ovary; Quinolines; Receptors, Estrogen; Receptors, G-Protein-Coupled; RNA Interference; Signal Transduction; Stromal Cells; Transfection

2015
G protein-coupled estrogen receptor (GPER) mediates NSCLC progression induced by 17β-estradiol (E2) and selective agonist G1.
    Medical oncology (Northwood, London, England), 2015, Volume: 32, Issue:4

    Topics: Adenocarcinoma; Aged; Animals; Apoptosis; Blotting, Western; Carcinogens; Carcinoma, Non-Small-Cell Lung; Cell Adhesion; Cell Movement; Cell Proliferation; Cyclopentanes; Disease Progression; Estradiol; Estrogen Receptor Antagonists; Female; Fulvestrant; Humans; Immunoenzyme Techniques; Lung Neoplasms; Lymphatic Metastasis; Male; Mice; Middle Aged; Neoplasm Staging; Phosphorylation; Prognosis; Quinolines; Receptors, Estrogen; Receptors, G-Protein-Coupled; RNA, Small Interfering; Tissue Array Analysis; Tumor Cells, Cultured; Urethane; Xenograft Model Antitumor Assays

2015
Activation of G-protein coupled estrogen receptor inhibits the proliferation of cervical cancer cells via sustained activation of ERK1/2.
    Cell biochemistry and function, 2015, Volume: 33, Issue:3

    Topics: Cell Line, Tumor; Cell Proliferation; Cyclin B; Cyclopentanes; ErbB Receptors; Female; G2 Phase Cell Cycle Checkpoints; HeLa Cells; Humans; M Phase Cell Cycle Checkpoints; MCF-7 Cells; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Quinolines; Receptors, G-Protein-Coupled; RNA Interference; RNA, Small Interfering; Signal Transduction; Uterine Cervical Neoplasms

2015
Are we facing a potential effective treatment for endometriosis?
    Fertility and sterility, 2015, Volume: 103, Issue:5

    Topics: Apoptosis; Cell Proliferation; Cyclopentanes; Endometriosis; Female; Humans; M Phase Cell Cycle Checkpoints; Ovarian Cysts; Ovary; Quinolines; Receptors, Estrogen; Receptors, G-Protein-Coupled; Stromal Cells

2015
GPR30 Mediates the Fast Effect of Estrogen on Mouse Blastocyst and its Role in Implantation.
    Reproductive sciences (Thousand Oaks, Calif.), 2015, Volume: 22, Issue:10

    Topics: Animals; Blastocyst; Calcium Signaling; Cell Line; Coculture Techniques; Cyclopentanes; Embryo Culture Techniques; Embryo Implantation; Enzyme Activation; Estradiol; Female; Mice; Pregnancy; Quinolines; Receptors, Estrogen; Receptors, G-Protein-Coupled; Time Factors; Type C Phospholipases

2015
Activation of novel estrogen receptor GPER results in inhibition of cardiocyte apoptosis and cardioprotection.
    Molecular medicine reports, 2015, Volume: 12, Issue:2

    Topics: Adenosine Triphosphatases; Animals; Apoptosis; bcl-2-Associated X Protein; Cardiotonic Agents; Cell Hypoxia; Cell Line; Cell Survival; Cyclopentanes; Embryo, Mammalian; Estradiol; Gene Expression Regulation; Models, Biological; Myocardial Reperfusion Injury; Myocytes, Cardiac; Proto-Oncogene Proteins c-bcl-2; Quinolines; Rats; Receptors, G-Protein-Coupled; Signal Transduction; Superoxide Dismutase; Tumor Necrosis Factor-alpha

2015
Rapid effects of the G-protein coupled oestrogen receptor (GPER) on learning and dorsal hippocampus dendritic spines in female mice.
    Physiology & behavior, 2015, Oct-01, Volume: 149

    Topics: Analysis of Variance; Animals; Cyclopentanes; Dendritic Spines; Dose-Response Relationship, Drug; Female; Hippocampus; Learning; Mice; Ovariectomy; Quinolines; Receptors, G-Protein-Coupled; Recognition, Psychology; Silver Staining; Social Behavior; Time Factors

2015
Estradiol and GPER Activation Differentially Affect Cell Proliferation but Not GPER Expression in the Hippocampus of Adult Female Rats.
    PloS one, 2015, Volume: 10, Issue:6

    Topics: Animals; Benzodioxoles; Body Weight; Cell Proliferation; Cyclopentanes; Dentate Gyrus; Estradiol; Female; Gene Expression Regulation; Hippocampus; Ki-67 Antigen; Organ Size; Quinolines; Rats; Receptors, G-Protein-Coupled

2015
Activation of G protein-coupled estrogen receptor 1 (GPER-1) decreases fluid intake in female rats.
    Hormones and behavior, 2015, Volume: 73

    Topics: Angiotensin II; Animals; Cyclopentanes; Down-Regulation; Drinking; Eating; Energy Metabolism; Estradiol; Female; Homeostasis; Quinolines; Rats; Rats, Long-Evans; Receptors, G-Protein-Coupled

2015
GPER agonist G-1 decreases adrenocortical carcinoma (ACC) cell growth in vitro and in vivo.
    Oncotarget, 2015, Aug-07, Volume: 6, Issue:22

    Topics: Adolescent; Adrenal Cortex Neoplasms; Adrenocortical Carcinoma; Adult; Animals; Apoptosis; Cell Cycle Checkpoints; Cell Proliferation; Cyclopentanes; DNA Damage; Female; Humans; Male; Mice; Mice, Nude; Middle Aged; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Phosphorylation; Quinolines; Receptors, Estrogen; Receptors, G-Protein-Coupled; Signal Transduction

2015
SIRT1 is involved in oncogenic signaling mediated by GPER in breast cancer.
    Cell death & disease, 2015, Jul-30, Volume: 6

    Topics: Animals; Antineoplastic Agents, Phytogenic; Benzamides; Breast Neoplasms; Cell Cycle Checkpoints; Cell Line, Tumor; Cell Proliferation; Cyclopentanes; ErbB Receptors; Estradiol; Etoposide; Female; Fibroblasts; Gene Expression Regulation, Neoplastic; Humans; Mice, Nude; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Naphthols; Primary Cell Culture; Proto-Oncogene Proteins c-fos; Quinolines; Receptors, Estrogen; Receptors, G-Protein-Coupled; Signal Transduction; Sirtuin 1; Transcription Factor AP-1; Xenograft Model Antitumor Assays

2015
G protein-coupled receptor 30 ligand G-1 increases aryl hydrocarbon receptor signalling by inhibition of tubulin assembly and cell cycle arrest in human MCF-7 cells.
    Archives of toxicology, 2016, Volume: 90, Issue:8

    Topics: Animals; Cell Culture Techniques; Cell Cycle Checkpoints; Cyclopentanes; Estrogen Receptor alpha; Female; Humans; Ligands; MCF-7 Cells; Quinolines; Receptor Cross-Talk; Receptors, Aryl Hydrocarbon; Receptors, Estrogen; Receptors, G-Protein-Coupled; Signal Transduction; Swine; Transcription, Genetic; Tubulin

2016
Cytoplasmic kinases downstream of GPR30 suppress gonadotropin-releasing hormone (GnRH)-induced luteinizing hormone secretion from bovine anterior pituitary cells.
    The Journal of reproduction and development, 2016, Volume: 62, Issue:1

    Topics: Animals; Butadienes; Cattle; Cells, Cultured; Cyclic AMP-Dependent Protein Kinases; Cyclopentanes; Cytoplasm; Estradiol; Gene Expression Regulation, Enzymologic; Gonadotropin-Releasing Hormone; Isoquinolines; Ligands; Luteinizing Hormone; MAP Kinase Kinase Kinases; Nitriles; Phosphorylation; Pituitary Gland, Anterior; Quinolines; Receptors, G-Protein-Coupled; Sulfonamides

2016
Detection of the Phosphorylation of the Estrogen Receptor α as an Outcome of GPR30 Activation.
    Methods in molecular biology (Clifton, N.J.), 2016, Volume: 1366

    Topics: Animals; Blotting, Western; Cell Line; Cyclopentanes; Electrophoresis, Polyacrylamide Gel; Estradiol; Estrogen Receptor alpha; Female; Hippocampus; Male; Mice; Orchiectomy; Ovariectomy; Phosphorylation; Quinolines; Receptor Cross-Talk; Receptors, Estrogen; Receptors, G-Protein-Coupled; Serine; Signal Transduction; Workflow

2016
Epileptogenic effects of G protein-coupled estrogen receptor 1 in the rat pentylenetetrazole kindling model of epilepsy.
    Pharmacological reports : PR, 2016, Volume: 68, Issue:1

    Topics: Animals; Cerebral Cortex; Cyclopentanes; Epilepsy; Estradiol; Kindling, Neurologic; Male; Pentylenetetrazole; Quinolines; Rats; Rats, Wistar; Receptors, Estrogen; Receptors, G-Protein-Coupled

2016
A New Signaling Pathway for HCV Inhibition by Estrogen: GPR30 Activation Leads to Cleavage of Occludin by MMP-9.
    PloS one, 2016, Volume: 11, Issue:1

    Topics: Carcinoma, Hepatocellular; Cell Line, Tumor; Cyclopentanes; Estrogen Antagonists; Estrogens; Hepacivirus; Host-Pathogen Interactions; Humans; Immunoblotting; Liver Neoplasms; Matrix Metalloproteinase 9; Matrix Metalloproteinase Inhibitors; MCF-7 Cells; Occludin; Phenyl Ethers; Proteolysis; Quinolines; Receptors, Estrogen; Receptors, G-Protein-Coupled; Reverse Transcriptase Polymerase Chain Reaction; RNA Interference; RNA, Viral; Signal Transduction; Tamoxifen

2016
Understanding the molecular basis of agonist/antagonist mechanism of GPER1/GPR30 through structural and energetic analyses.
    The Journal of steroid biochemistry and molecular biology, 2016, Volume: 158

    Topics: Benzodioxoles; Binding Sites; Cyclopentanes; Humans; Lipid Bilayers; Molecular Dynamics Simulation; Protein Conformation; Quinolines; Receptors, Estrogen; Receptors, G-Protein-Coupled

2016
GPER activation ameliorates aortic remodeling induced by salt-sensitive hypertension.
    American journal of physiology. Heart and circulatory physiology, 2016, Apr-15, Volume: 310, Issue:8

    Topics: Angiotensin II; Animals; Animals, Congenic; Aorta; Blood Pressure; Cyclopentanes; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Genotype; Glycosaminoglycans; Hypertension; Lipid Peroxidation; Oxidative Stress; Phenylephrine; Quinolines; Rats, Transgenic; Receptors, G-Protein-Coupled; Renin; Sodium Chloride, Dietary; Time Factors; Vascular Remodeling

2016
17β-Estradiol and Agonism of G-protein-Coupled Estrogen Receptor Enhance Hippocampal Memory via Different Cell-Signaling Mechanisms.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2016, Mar-16, Volume: 36, Issue:11

    Topics: Animals; Anthracenes; Cyclopentanes; Dose-Response Relationship, Drug; Enzyme Inhibitors; Estradiol; Estrogens; Female; Hippocampus; Mice; Mice, Inbred C57BL; Ovariectomy; Quinolines; Receptors, Estrogen; Recognition, Psychology; Signal Transduction; Time Factors

2016
The G Protein-Coupled Estrogen Receptor Agonist G-1 Inhibits Nuclear Estrogen Receptor Activity and Stimulates Novel Phosphoproteomic Signatures.
    Toxicological sciences : an official journal of the Society of Toxicology, 2016, Volume: 151, Issue:2

    Topics: Antineoplastic Agents, Hormonal; Benzhydryl Compounds; Breast Neoplasms; Cell Proliferation; Chromatography, High Pressure Liquid; Cyclopentanes; Dose-Response Relationship, Drug; Estradiol; Genistein; Humans; MCF-7 Cells; Nitriles; Phenols; Phosphoproteins; Propionates; Proteomics; Pyrazoles; Quinolines; Receptors, Estrogen; Receptors, G-Protein-Coupled; Signal Transduction; Tandem Mass Spectrometry; Time Factors

2016
Activation of G-Protein-Coupled Estrogen Receptor Inhibits the Migration of Human Nonsmall Cell Lung Cancer Cells via IKK-β/NF-κB Signals.
    DNA and cell biology, 2016, Volume: 35, Issue:8

    Topics: Cell Line, Tumor; Cell Movement; Cyclopentanes; Epithelial Cells; Fibroblasts; Gene Expression Regulation, Neoplastic; Humans; I-kappa B Kinase; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; NF-kappa B; Nicotinic Acids; Nitriles; Organ Specificity; Quinolines; Receptors, Estrogen; Receptors, G-Protein-Coupled; Respiratory Mucosa; Signal Transduction; Sulfones

2016
Assessment of cell line competence for studies of pharmacological GPR30 modulation.
    Journal of receptor and signal transduction research, 2017, Volume: 37, Issue:2

    Topics: Animals; Aorta; Breast Neoplasms; Cattle; Cyclopentanes; Endothelial Cells; Estradiol; Estrogen Receptor alpha; Estrogens; Female; Gene Expression Regulation, Neoplastic; Humans; MAP Kinase Signaling System; MCF-7 Cells; Oncogene Protein v-akt; Phosphorylation; Proto-Oncogene Proteins c-fos; Quinolines; Receptors, Estrogen; Receptors, G-Protein-Coupled; Signal Transduction

2017
G-1 exerts neuroprotective effects through G protein-coupled estrogen receptor 1 following spinal cord injury in mice.
    Bioscience reports, 2016, Volume: 36, Issue:4

    Topics: Animals; Apoptosis; Caspase 3; Cyclopentanes; Disease Models, Animal; Estrogens; Extracellular Signal-Regulated MAP Kinases; Female; MAP Kinase Signaling System; Mice; Mice, Inbred C57BL; Neuroprotective Agents; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-bcl-2; Quinolines; Receptors, Estrogen; Receptors, G-Protein-Coupled; Signal Transduction; Spinal Cord Injuries

2016
Activation of GPER suppresses migration and angiogenesis of triple negative breast cancer via inhibition of NF-κB/IL-6 signals.
    Cancer letters, 2017, 02-01, Volume: 386

    Topics: Animals; Antibodies; Antineoplastic Agents; Binding Sites; Cell Line, Tumor; Cell Movement; Cyclopentanes; Dose-Response Relationship, Drug; Female; Human Umbilical Vein Endothelial Cells; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Interleukin-6; Mice, Nude; Middle Aged; Neoplasm Invasiveness; Neovascularization, Pathologic; Neovascularization, Physiologic; NF-kappa B; Phosphorylation; Promoter Regions, Genetic; Quinolines; Receptors, Estrogen; Receptors, G-Protein-Coupled; Signal Transduction; STAT3 Transcription Factor; Time Factors; Triple Negative Breast Neoplasms; Tumor Burden; Vascular Endothelial Growth Factor A; Xenograft Model Antitumor Assays

2017
Rapid effects of dorsal hippocampal G-protein coupled estrogen receptor on learning in female mice.
    Psychoneuroendocrinology, 2017, Volume: 77

    Topics: Animals; Behavior, Animal; Cues; Cyclopentanes; Female; Hippocampus; Hormones; Learning; Mice; Quinolines; Receptors, Estrogen; Recognition, Psychology; Social Behavior

2017
G protein-coupled estrogen receptor and estrogen receptor ligands regulate colonic motility and visceral pain.
    Neurogastroenterology and motility, 2017, Volume: 29, Issue:7

    Topics: Animals; Colon; Cyclopentanes; Dose-Response Relationship, Drug; Estradiol; Female; Gastrointestinal Motility; Humans; Ligands; Male; Mice; Organ Culture Techniques; Quinolines; Receptors, Estrogen; Receptors, G-Protein-Coupled; Visceral Pain

2017
G-1 Inhibits Breast Cancer Cell Growth via Targeting Colchicine-Binding Site of Tubulin to Interfere with Microtubule Assembly.
    Molecular cancer therapeutics, 2017, Volume: 16, Issue:6

    Topics: Animals; Antineoplastic Agents; Apoptosis; Binding Sites; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Cyclopentanes; Disease Models, Animal; Female; Humans; Mice; Microtubules; Protein Binding; Protein Multimerization; Quinolines; Receptors, Estrogen; Tubulin; Tubulin Modulators; Xenograft Model Antitumor Assays

2017
Activation of G protein-coupled estrogen receptor 1 induces coronary artery relaxation via Epac/Rap1-mediated inhibition of RhoA/Rho kinase pathway in parallel with PKA.
    PloS one, 2017, Volume: 12, Issue:3

    Topics: Animals; Cells, Cultured; Coronary Vessels; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Cyclopentanes; Guanine Nucleotide Exchange Factors; Hydrazones; Isoxazoles; Muscle, Smooth, Vascular; Myosin-Light-Chain Phosphatase; Phosphorylation; Quinolines; rap1 GTP-Binding Proteins; Receptors, Estrogen; rho-Associated Kinases; rhoA GTP-Binding Protein; RNA Interference; RNA, Small Interfering; Signal Transduction; Swine; Thionucleotides

2017
Epigenetic down regulation of G protein-coupled estrogen receptor (GPER) functions as a tumor suppressor in colorectal cancer.
    Molecular cancer, 2017, 05-05, Volume: 16, Issue:1

    Topics: Aged; Animals; Apoptosis; Cell Cycle Checkpoints; Cell Proliferation; Colorectal Neoplasms; Cyclopentanes; Epigenesis, Genetic; Estrogens; Female; Gene Expression Regulation, Neoplastic; HCT116 Cells; Humans; Male; MAP Kinase Signaling System; Mice; Middle Aged; Neoplasms, Hormone-Dependent; Quinolines; Reactive Oxygen Species; Receptors, Estrogen; Receptors, G-Protein-Coupled; Xenograft Model Antitumor Assays

2017
GPER agonist dilates mesenteric arteries via PI3K-Akt-eNOS and potassium channels in both sexes.
    Life sciences, 2017, Aug-15, Volume: 183

    Topics: Animals; Cyclopentanes; Dose-Response Relationship, Drug; Estrogens; Female; Male; Mesenteric Arteries; Nitric Oxide Synthase Type III; Phosphatidylinositol 3-Kinase; Potassium Channel Blockers; Potassium Channels; Proto-Oncogene Proteins c-akt; Quinolines; Rats; Rats, Wistar; Receptors, G-Protein-Coupled; Signal Transduction; Vasodilation

2017
Suppression of store-operated Ca
    The Biochemical journal, 2017, 10-23, Volume: 474, Issue:21

    Topics: Amino Acid Substitution; Animals; Bradykinin; Calcium Signaling; Cyclopentanes; Endothelial Cells; HEK293 Cells; Humans; Models, Biological; Mutation, Missense; Neoplasm Proteins; Quinolines; Stromal Interaction Molecule 1; Swine

2017
The activation of the G protein-coupled estrogen receptor (GPER) inhibits the proliferation of mouse melanoma K1735-M2 cells.
    Chemico-biological interactions, 2017, Nov-01, Volume: 277

    Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Cyclopentanes; Melanoma; Mice; Quinolines; Receptors, Estrogen; Receptors, G-Protein-Coupled

2017
The activation of G protein-coupled estrogen receptor induces relaxation via cAMP as well as potentiates contraction via EGFR transactivation in porcine coronary arteries.
    PloS one, 2018, Volume: 13, Issue:1

    Topics: Animals; Cells, Cultured; Coronary Vessels; Cyclopentanes; ErbB Receptors; Flavonoids; Humans; In Vitro Techniques; MAP Kinase Signaling System; Models, Cardiovascular; Myocytes, Smooth Muscle; Quinazolines; Quinolines; Receptors, Estrogen; Receptors, G-Protein-Coupled; Swine; Transcriptional Activation; Tyrphostins; Vasodilation

2018
Selective activation of estrogen receptors, ERα and GPER-1, rapidly decreases food intake in female rats.
    Hormones and behavior, 2018, Volume: 103

    Topics: Animals; Cyclopentanes; Eating; Estradiol; Estrogen Receptor alpha; Estrogens; Female; Ovariectomy; Phenols; Pyrazoles; Quinolines; Rats; Rats, Long-Evans; Receptors, G-Protein-Coupled; Selective Estrogen Receptor Modulators; Signal Transduction; Time Factors

2018
The G protein-coupled estrogen receptor agonist, G-1, attenuates BK channel activation in cerebral arterial smooth muscle cells.
    Pharmacology research & perspectives, 2018, Volume: 6, Issue:4

    Topics: Animals; Cerebral Arteries; Cyclopentanes; Estrogens; Female; Large-Conductance Calcium-Activated Potassium Channels; Myocytes, Smooth Muscle; Quinolines; Rats, Sprague-Dawley; Receptors, Estrogen; Receptors, G-Protein-Coupled

2018
G-1 exhibit antidepressant effect, increase of hippocampal ERs expression and improve hippocampal redox status in aged female rats.
    Behavioural brain research, 2019, 02-01, Volume: 359

    Topics: Aging; Animals; Cyclopentanes; Disease Models, Animal; Estrogens; Exploratory Behavior; Female; Gene Expression Regulation; Hippocampus; Maze Learning; Membrane Potential, Mitochondrial; Mitochondria; Mood Disorders; Ovariectomy; Oxidation-Reduction; Oxidative Stress; Quinolines; Rats; Rats, Sprague-Dawley; Receptors, Estrogen; Superoxide Dismutase; Swimming

2019
G-protein-coupled estrogen receptor suppresses the migration of osteosarcoma cells via post-translational regulation of Snail.
    Journal of cancer research and clinical oncology, 2019, Volume: 145, Issue:1

    Topics: Bone Neoplasms; Cell Line; Cell Line, Tumor; Cell Movement; Cyclopentanes; Disease Progression; Down-Regulation; Epithelial-Mesenchymal Transition; F-Box Proteins; Humans; Neoplasm Invasiveness; Neoplasm Metastasis; Osteosarcoma; Protein Processing, Post-Translational; Quinolines; Receptors, Estrogen; Receptors, G-Protein-Coupled; RNA, Messenger; Snail Family Transcription Factors; Survival Rate; Ubiquitin-Protein Ligase Complexes

2019
GPER Mediates a Feedforward FGF2/FGFR1 Paracrine Activation Coupling CAFs to Cancer Cells toward Breast Tumor Progression.
    Cells, 2019, 03-07, Volume: 8, Issue:3

    Topics: Breast Neoplasms; Cancer-Associated Fibroblasts; Cell Line, Tumor; Cell Movement; Connective Tissue Growth Factor; Culture Media, Conditioned; Cyclopentanes; Disease Progression; Estradiol; Female; Fibroblast Growth Factor 2; Humans; Neoplasm Invasiveness; Paracrine Communication; Proto-Oncogene Proteins c-fos; Quinolines; Receptor, Fibroblast Growth Factor, Type 1; Receptors, Estrogen; Receptors, G-Protein-Coupled; Signal Transduction; Up-Regulation

2019
G protein-coupled estrogen receptor-1 agonist induces chemotherapeutic effect via ER stress signaling in gastric cancer.
    BMB reports, 2019, Volume: 52, Issue:11

    Topics: Animals; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Cyclopentanes; Endoplasmic Reticulum Stress; Estrogens; Female; Gene Expression Regulation, Neoplastic; Humans; MCF-7 Cells; Mice; Mice, Nude; Quinolines; Receptors, Estrogen; Receptors, G-Protein-Coupled; Signal Transduction; Stomach Neoplasms; Tamoxifen; Xenograft Model Antitumor Assays

2019
GPER stabilizes F-actin cytoskeleton and activates TAZ via PLCβ-PKC and Rho/ROCK-LIMK-Cofilin pathway.
    Biochemical and biophysical research communications, 2019, 08-27, Volume: 516, Issue:3

    Topics: Actin Cytoskeleton; Actin Depolymerizing Factors; Actins; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cyclopentanes; Epithelial Cells; Female; Gene Expression Regulation, Neoplastic; Humans; Lim Kinases; Mammary Glands, Human; Phospholipase C beta; Protein Kinase C; Quinolines; Receptors, Estrogen; Receptors, G-Protein-Coupled; rho-Associated Kinases; RNA, Small Interfering; Signal Transduction; Trans-Activators; Transcriptional Coactivator with PDZ-Binding Motif Proteins

2019
G-Protein-Coupled Estrogen Receptor Agonist G1 Improves Diastolic Function and Attenuates Cardiac Renin-Angiotensin System Activation in Estrogen-Deficient Hypertensive Rats.
    Journal of cardiovascular pharmacology, 2019, Volume: 74, Issue:5

    Topics: Angiotensin II; Angiotensin-Converting Enzyme 2; Animals; Cyclopentanes; Diastole; Disease Models, Animal; Estrogens; Female; Hypertension; Myocardium; Ovariectomy; Peptidyl-Dipeptidase A; Proto-Oncogene Mas; Proto-Oncogene Proteins; Quinolines; Rats, Inbred SHR; Receptor, Angiotensin, Type 1; Receptors, G-Protein-Coupled; Renin-Angiotensin System; Signal Transduction; Ventricular Dysfunction, Left; Ventricular Function, Left

2019
G-Protein-Coupled Estrogen Receptor (GPER)-Specific Agonist G1 Induces ER Stress Leading to Cell Death in MCF-7 Cells.
    Biomolecules, 2019, 09-18, Volume: 9, Issue:9

    Topics: Activating Transcription Factor 6; Breast Neoplasms; Calcium; Cell Proliferation; Cell Survival; Cyclopentanes; eIF-2 Kinase; Endoplasmic Reticulum Chaperone BiP; Endoplasmic Reticulum Stress; Endoribonucleases; Female; Humans; MCF-7 Cells; Phosphorylation; Protein Serine-Threonine Kinases; Quinolines; Receptors, Estrogen; Receptors, G-Protein-Coupled; Unfolded Protein Response

2019
Activation of G-Protein-Coupled Receptor 30 Protects Neurons against Excitotoxicity through Inhibiting Excessive Autophagy Induced by Glutamate.
    ACS chemical neuroscience, 2019, 10-16, Volume: 10, Issue:10

    Topics: Animals; Autophagy; Benzodioxoles; Cell Survival; Cerebral Cortex; Cyclopentanes; Glutamic Acid; Mice; Neurons; Neuroprotective Agents; Phosphatidylinositol 3-Kinases; Phosphorylation; Proto-Oncogene Proteins c-akt; Quinolines; Receptors, Estrogen; Receptors, G-Protein-Coupled; Signal Transduction

2019
Regulation of beta adrenoceptor-mediated myocardial contraction and calcium dynamics by the G protein-coupled estrogen receptor 1.
    Biochemical pharmacology, 2020, Volume: 171

    Topics: Adrenergic beta-Antagonists; Animals; Benzodioxoles; Calcium; Calcium Channels, L-Type; Cells, Cultured; Cyclopentanes; Estrogen Receptor alpha; Isoproterenol; Kinetics; Male; Mice; Myocardial Contraction; Myocardium; Myocytes, Cardiac; Phosphorylation; Quinolines; Receptors, Adrenergic, beta; Receptors, G-Protein-Coupled

2020
The environmental hormone nonylphenol interferes with the therapeutic effects of G protein-coupled estrogen receptor specific agonist G-1 on murine allergic rhinitis.
    International immunopharmacology, 2020, Volume: 78

    Topics: Animals; Cyclopentanes; Disease Models, Animal; Drug Interactions; Endocrine Disruptors; Estrogens; Female; Humans; Mice; Nasal Mucosa; Ovalbumin; Phenols; Quinolines; Receptors, Estrogen; Receptors, G-Protein-Coupled; Rhinitis, Allergic; T-Lymphocytes, Regulatory; Th2 Cells

2020
The activation of the G protein-coupled estrogen receptor (GPER) prevents and regresses cardiac hypertrophy.
    Life sciences, 2020, Feb-01, Volume: 242

    Topics: Animals; Animals, Newborn; Blotting, Western; Cardiomegaly; Cells, Cultured; Cyclopentanes; Echocardiography; Eplerenone; Male; Myocytes, Cardiac; Quinolines; Rats; Rats, Inbred SHR; Rats, Wistar; Real-Time Polymerase Chain Reaction; Receptors, G-Protein-Coupled

2020
Rapid effects of estradiol and its receptor agonists on object recognition and object placement in adult male zebrafish.
    Behavioural brain research, 2020, 04-20, Volume: 384

    Topics: Animals; Brain; Brain-Derived Neurotrophic Factor; Cyclopentanes; Estradiol; Estrogen Receptor alpha; Estrogen Receptor beta; Estrogens; Learning; Male; Memory Consolidation; Nitriles; Phenols; Pyrazoles; Quinolines; Receptors, AMPA; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate; Recognition, Psychology; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Spatial Memory; Synaptophysin; TOR Serine-Threonine Kinases; Zebrafish; Zebrafish Proteins

2020
Aldosterone-induced hypertension is sex-dependent, mediated by T cells and sensitive to GPER activation.
    Cardiovascular research, 2021, 02-22, Volume: 117, Issue:3

    Topics: Aldosterone; Animals; Antihypertensive Agents; Benzodioxoles; Blood Pressure; Cyclopentanes; Disease Models, Animal; Estrogen Antagonists; Female; Homeodomain Proteins; Hypertension; Male; Mice, Inbred C57BL; Mice, Knockout; Ovariectomy; Quinolines; Receptors, Estrogen; Receptors, G-Protein-Coupled; Sex Factors; Signal Transduction; T-Lymphocytes

2021
Evidence for G-Protein-Coupled Estrogen Receptor as a Pronatriuretic Factor.
    Journal of the American Heart Association, 2020, 05-18, Volume: 9, Issue:10

    Topics: Animals; Cyclopentanes; Endothelin-1; Estradiol; Estrogens; Female; Kidney Medulla; Male; Mice, Knockout; Natriuresis; Ovariectomy; Quinolines; Rats, Sprague-Dawley; Receptor, Endothelin A; Receptor, Endothelin B; Receptors, Estrogen; Receptors, G-Protein-Coupled; Sex Factors; Signal Transduction

2020
G protein-coupled estrogen receptor 1 (GPER-1) and agonist G-1 inhibit growth of ovarian cancer cells by activation of anti-tumoral transcriptome responses: impact of GPER-1 mRNA on survival.
    Journal of cancer research and clinical oncology, 2020, Volume: 146, Issue:12

    Topics: Apoptosis; Cell Line, Tumor; Cell Proliferation; Cyclopentanes; Female; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Humans; Ovarian Neoplasms; Quinolines; Receptors, Estrogen; Receptors, G-Protein-Coupled; RNA, Messenger; Transcriptome

2020
Activation of G protein-coupled estrogen receptor 1 ameliorates proximal tubular injury and proteinuria in Dahl salt-sensitive female rats.
    American journal of physiology. Regulatory, integrative and comparative physiology, 2021, 03-01, Volume: 320, Issue:3

    Topics: Albuminuria; Animals; Arterial Pressure; Cell Adhesion Molecules; Cyclopentanes; Disease Models, Animal; Female; Hypertension; Kidney Diseases; Kidney Glomerulus; Kidney Tubules, Proximal; Quinolines; Rats, Inbred Dahl; Receptors, G-Protein-Coupled; Signal Transduction; Sodium Chloride, Dietary

2021
Amplifying effect of chronic lisinopril therapy on diastolic function and the angiotensin-(1-7) Axis by the G1 agonist in ovariectomized spontaneously hypertensive rats.
    Translational research : the journal of laboratory and clinical medicine, 2021, Volume: 235

    Topics: Angiotensin I; Animals; Cyclopentanes; Diastole; Female; Lisinopril; Ovariectomy; Peptide Fragments; Quinolines; Rats; Rats, Inbred SHR; Receptors, G-Protein-Coupled; Renin-Angiotensin System

2021
G protein-coupled estrogen receptor regulates the KLF2-dependent eNOS expression by activating of Ca
    Biochemical pharmacology, 2021, Volume: 192

    Topics: Calcium Signaling; Cyclopentanes; ErbB Receptors; Gene Expression; Human Umbilical Vein Endothelial Cells; Humans; Kruppel-Like Transcription Factors; Nitric Oxide Synthase Type III; Quinolines; Receptors, Estrogen; Receptors, G-Protein-Coupled

2021
4-Methyl-2,4-bis(4-hydroxyphenyl)pent-1-ene (MBP) Targets Estrogen Receptor β, to Evoke the Resistance of Human Breast Cancer MCF-7 Cells to G-1, an Agonist for G Protein-Coupled Estrogen Receptor 1.
    Biological & pharmaceutical bulletin, 2021, Volume: 44, Issue:10

    Topics: Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Cell Proliferation; Cyclopentanes; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Estrogen Receptor beta; Female; Humans; MCF-7 Cells; Phenols; Quinolines; Receptors, Estrogen; Receptors, G-Protein-Coupled; Signal Transduction

2021
GPER Agonist G-1 Disrupts Tubulin Dynamics and Potentiates Temozolomide to Impair Glioblastoma Cell Proliferation.
    Cells, 2021, 12-07, Volume: 10, Issue:12

    Topics: Animals; Apoptosis; Cell Proliferation; Cyclopentanes; Gene Expression Regulation, Neoplastic; Glioblastoma; Humans; Mice; Mitosis; Quinolines; Receptors, Estrogen; Receptors, G-Protein-Coupled; Temozolomide; Tubulin; Xenograft Model Antitumor Assays

2021