cyclomarin-a and viscosin

We have identified a strain of Streptomyces in which aerial hyphae formation appears to be especially sensitive to inhibition by protein kinase inhibitors. Using this assay, a number of bacterial cultures have been screened and novel inhibitors of eukaryotic protein kinases have been identified. Since M. tuberculosis possesses multiple eukaryotic-like protein kinase genes, we tested the active kinase inhibitors for the inhibition of mycobacterial growth and obtained several potent compounds. This identifies a new biochemical class of antimycobacterial agents.

Topics: Bacillus; Bacterial Proteins; Enzyme Inhibitors; Lipopeptides; Lipoproteins; Mycobacterium tuberculosis; Oligopeptides; Peptides, Cyclic; Protein Kinase Inhibitors; Pseudomonas; Signal Transduction; Spores, Bacterial; Streptomyces