cyclomarin-a has been researched along with viscosin* in 1 studies
1 other study(ies) available for cyclomarin-a and viscosin
Article | Year |
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Identifying protein kinase inhibitors using an assay based on inhibition of aerial hyphae formation in Streptomyces.
We have identified a strain of Streptomyces in which aerial hyphae formation appears to be especially sensitive to inhibition by protein kinase inhibitors. Using this assay, a number of bacterial cultures have been screened and novel inhibitors of eukaryotic protein kinases have been identified. Since M. tuberculosis possesses multiple eukaryotic-like protein kinase genes, we tested the active kinase inhibitors for the inhibition of mycobacterial growth and obtained several potent compounds. This identifies a new biochemical class of antimycobacterial agents. Topics: Bacillus; Bacterial Proteins; Enzyme Inhibitors; Lipopeptides; Lipoproteins; Mycobacterium tuberculosis; Oligopeptides; Peptides, Cyclic; Protein Kinase Inhibitors; Pseudomonas; Signal Transduction; Spores, Bacterial; Streptomyces | 2002 |