Compounds > cycloleucine

cycloleucine and pld118

cycloleucine has been researched along with pld118 in 10 studies

Research

Studies (10)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's2 (20.00)18.2507
2000's7 (70.00)29.6817
2010's1 (10.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Ziegelbauer, K1
Babczinski, P; Schönfeld, W; Ziegelbauer, K1
Dorrell, S1
Bacher, J; Groll, AH; Kelaher, AM; Mickiene, D; Petraitiene, R; Petraitis, V; Sarafandi, AA; Sein, T; Walsh, TJ2
Bogaards, JJ; Mildner, B; Oresković, K; Parnham, MJ; Schrander, F; Schut, MW1
Yeates, C1
Ergovic, G; Galic, T; Geschke, U; Hasenoehrl, A; Marsic, N; Mittendorf, J; Schmidt, A; Schoenfeld, W; Skerlev, M1
Avdagić, A; Bratos, I; Dumić, M; Fistrić, I; Hamersak, Z; Ilijas, M; Marković, VG; Novak, P; Tepes, P1
Ábrahámi, R; Forró, E; Fülöp, F; Kiss, L; Orsy, G1

Reviews

1 review(s) available for cycloleucine and pld118

ArticleYear
Icofungipen (PLIVA).
    Current opinion in investigational drugs (London, England : 2000), 2005, Volume: 6, Issue:8

    Topics: Animals; Antifungal Agents; Clinical Trials, Phase I as Topic; Clinical Trials, Phase II as Topic; Contraindications; Cycloleucine; Humans; Mycoses; Structure-Activity Relationship

2005

Other Studies

9 other study(ies) available for cycloleucine and pld118

ArticleYear
Decreased accumulation or increased isoleucyl-tRNA synthetase activity confers resistance to the cyclic beta-amino acid BAY 10-8888 in Candida albicans and Candida tropicalis.
    Antimicrobial agents and chemotherapy, 1998, Volume: 42, Issue:7

    Topics: Candida; Candida albicans; Cell Division; Cycloleucine; Drug Resistance, Microbial; Isoleucine-tRNA Ligase; Microbial Sensitivity Tests; Mutation

1998
Molecular mode of action of the antifungal beta-amino acid BAY 10-8888.
    Antimicrobial agents and chemotherapy, 1998, Volume: 42, Issue:9

    Topics: Amino Acids; Antifungal Agents; Biological Transport, Active; Candida albicans; Culture Media; Cycloleucine; Isoleucine; Isoleucine-tRNA Ligase; Protein Biosynthesis

1998
Overcoming drug-resistant yeast infections.
    Drug discovery today, 2002, Mar-15, Volume: 7, Issue:6

    Topics: Antifungal Agents; Cycloleucine; Drug Resistance, Fungal; Humans; Mycoses; Yeasts

2002
Efficacy of PLD-118, a novel inhibitor of candida isoleucyl-tRNA synthetase, against experimental oropharyngeal and esophageal candidiasis caused by fluconazole-resistant C. albicans.
    Antimicrobial agents and chemotherapy, 2004, Volume: 48, Issue:10

    Topics: Animals; Antifungal Agents; Area Under Curve; Candida albicans; Candidiasis; Candidiasis, Oral; Cycloleucine; Drug Resistance, Fungal; Enzyme Inhibitors; Esophageal Diseases; Female; Fluconazole; Half-Life; Immunosuppression Therapy; Isoleucine-tRNA Ligase; Rabbits

2004
The novel antifungal agent PLD-118 is neither metabolized by liver microsomes nor inhibits cytochrome P450 in vitro.
    Biopharmaceutics & drug disposition, 2005, Volume: 26, Issue:1

    Topics: Administration, Oral; Animals; Antifungal Agents; Chemistry, Pharmaceutical; Cycloleucine; Cytochrome P-450 Enzyme System; Dogs; Drug Evaluation, Preclinical; Humans; Microsomes, Liver; Rats; Ribosomal Protein S9; Ribosomal Proteins

2005
Efficacy, plasma pharmacokinetics, and safety of icofungipen, an inhibitor of Candida isoleucyl-tRNA synthetase, in treatment of experimental disseminated candidiasis in persistently neutropenic rabbits.
    Antimicrobial agents and chemotherapy, 2005, Volume: 49, Issue:5

    Topics: Animals; Antifungal Agents; Candida albicans; Candidiasis; Culture Media; Cycloleucine; Female; Immunosuppression Therapy; Isoleucine-tRNA Ligase; Kidney; Liver; Neutropenia; Rabbits; Spleen

2005
In vitro activity and in vivo efficacy of icofungipen (PLD-118), a novel oral antifungal agent, against the pathogenic yeast Candida albicans.
    Antimicrobial agents and chemotherapy, 2006, Volume: 50, Issue:9

    Topics: Animals; Antifungal Agents; Candida albicans; Candidiasis; Cycloleucine; Drug Interactions; Hydrogen-Ion Concentration; Isoleucine; Male; Mice; Microbial Sensitivity Tests; Rats; Rats, Sprague-Dawley; Temperature

2006
LC-NMR and LC-MS identification of an impurity in a novel antifungal drug icofungipen.
    Journal of pharmaceutical and biomedical analysis, 2009, Aug-15, Volume: 50, Issue:1

    Topics: Antifungal Agents; Chromatography, Liquid; Cycloleucine; Magnetic Resonance Spectroscopy; Mass Spectrometry

2009
Stereo- and Regiocontrolled Syntheses of Exomethylenic Cyclohexane β-Amino Acid Derivatives.
    Molecules (Basel, Switzerland), 2015, Nov-27, Volume: 20, Issue:12

    Topics: Amino Acids; Antifungal Agents; beta-Lactams; Cyclohexanes; Cycloleucine; Fungi; Hydroxylation; Molecular Structure; Oxidation-Reduction

2015