cycloheximide has been researched along with staurosporine in 161 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (0.62) | 18.7374 |
| 1990's | 107 (66.46) | 18.2507 |
| 2000's | 49 (30.43) | 29.6817 |
| 2010's | 4 (2.48) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Chang, LC; Cheenpracha, S; Foo, SH; Foss, AP; Ho, CC; Jee, JM; Lai, NS; Mar, AM; Seow, HF; Zhang, H | 1 |
| Barnes, SW; Bonamy, GM; Bopp, SE; Borboa, R; Bright, AT; Chatterjee, A; Che, J; Cohen, S; Dharia, NV; Diagana, TT; Fidock, DA; Froissard, P; Gagaring, K; Gettayacamin, M; Glynne, RJ; Gordon, P; Groessl, T; Kato, N; Kuhen, KL; Lee, MC; Mazier, D; McNamara, CW; Meister, S; Nagle, A; Nam, TG; Plouffe, DM; Richmond, W; Roland, J; Rottmann, M; Sattabongkot, J; Schultz, PG; Tuntland, T; Walker, JR; Winzeler, EA; Wu, T; Zhou, B; Zhou, Y | 1 |
| Bohnert, M; Dahse, HM; Hoffmeister, D; König, S; Scherer, O; Werz, O; Wiechmann, K | 1 |
| Gereke, M; Harzallah, D; Helaly, SE; Jansen, R; Noumeur, SR; Stadler, M; Stradal, TEB | 1 |
| Addo, EM; Anaya-Eugenio, GD; Carcache de Blanco, EJ; Ezzone, N; Henkin, JM; Kinghorn, AD; Ninh, TN; Ren, Y; Soejarto, DD | 1 |
| Alkhalaf, B; Ballejo, G; Gong, Y; Molnar, P; Murphy, LC; Murphy, LJ | 1 |
| Brass, LF | 1 |
| Heinrich, PC; Müllberg, J; Rose-John, S; Schooltink, H; Stoyan, T | 1 |
| González, AV; Maghazachi, AA; Phillips-Quagliata, JM; Rao, TD | 1 |
| Fernandez-Gallardo, S; Guntaka, RV; Kandala, JC; Lim, RW; Shukla, SD; Tripathi, YB | 1 |
| Messina, JL | 1 |
| al-Awqati, Q; Herzlinger, D; Koseki, C | 1 |
| Ikeda, K; Kikuchi, T; Matsumoto, T; Morimoto, K; Nakano, T; Ogata, E; Okazaki, R; Sakamoto, A; Urakawa, K | 1 |
| Benveniste, EN; Chung, IY; Kwon, J | 1 |
| Alkhalaf, B; Gong, Y; Murphy, LC; Murphy, LJ | 1 |
| Schatz-Munding, M; Ullrich, V | 1 |
| Bandyopadhyay, SK; Sen, GC | 1 |
| Inui, J; Kusuhara, H; Shimada, O | 1 |
| Knowles, GC; McCulloch, CA; McKeown, M; Sodek, J | 1 |
| Alm, GV; Eloranta, ML; Gobl, AE; Sandberg, K | 1 |
| Buchou, T; Mĕster, J | 1 |
| Kikuchi, T; Tamm, I; Zychlinsky, A | 1 |
| Davis, BB; Jacob, AK; Thomas, DJ; Zenser, TV | 1 |
| Berezesky, IK; Fargnoli, J; Holbrook, NJ; Maki, A; Trump, BF | 1 |
| Fujita, T; Hovanessian, AG; Sakakibara, J; Taniguchi, T; Watanabe, N | 1 |
| Greten, H; Humburg, I; Kalthoff, H; Roeder, C; Schmiegel, W; Thiele, HG | 1 |
| Coffee, KA; Cook, JA; Geisel, J; Halushka, PV; Wise, WC | 1 |
| Moore, JJ; Moore, RM; Vander Kooy, D | 1 |
| Beermann, ML; Shea, TB | 1 |
| Fukuda, T; Kishi, K; Maeyama, K; Mamune-Sato, R; Miura, Y; Takishima, T; Tanno, Y; Watanabe, T | 1 |
| Fujiki, H; Hirasawa, N; Ohashi, M; Ohuchi, K; Ozeki, T; Tamura, T; Tsurufuji, S; Watanabe, M | 1 |
| Levin, EG; Marotti, KR; Santell, L | 1 |
| Kachra, Z; Posner, BI; Yang, CR | 1 |
| Iitaka, M; Ishii, J; Kitahama, S | 1 |
| Carter, V; Gale, M; Parsons, M | 1 |
| Jacquemin-Sablon, A; Segal-Bendirdjian, E | 1 |
| Dewald, B; Fey, MF; Meier, RW; Niklaus, G; Tobler, A | 1 |
| Cruz-Reyes, J; Tata, JR | 1 |
| Catravas, JD; Ganapathy, V; Leibach, FH; Papapetropoulos, A; Ramamoorthy, JD; Ramamoorthy, S | 1 |
| Ayusawa, D; Fujii, M; Ide, T; Kaul, SC; Mitsui, Y; Ogata, T; Oishi, M; Tahara, H; Wadhwa, R | 1 |
| Atkins, KB; Troen, BR | 1 |
| Jenkins, TA; Snyder, TL; Wuthrich, RP | 1 |
| Azzi, A; Boscoboinik, D; Galeotti, T | 1 |
| Baglioni, C; Gorospe, M; Kumar, S | 1 |
| Hirata, Y; Imai, T; Kanno, K; Marumo, F | 1 |
| Canalis, E; Jeffrey, JJ; Ramsby, ML; Varghese, S | 1 |
| Bannon, GA; McMillan, PJ; Stanley, JS | 1 |
| Chin, KV; Hait, WN; Yang, JM | 1 |
| Griffith, DA; Jarvis, SM | 1 |
| Bowen, W; Michalopoulos, GK; Petersen, B; Yee, CJ; Zarnegar, R | 1 |
| Gurevich, M; Harel-Markowitz, E; Shemesh, M; Shore, LS | 1 |
| Aftab, DT; Hait, WN; Yang, JM | 1 |
| Fujimura, S; Kato, N; Miya, T; Sato, K; Tagawa, M; Takahashi, K | 1 |
| Burne, JF; Ishizaki, Y; Raff, MC | 1 |
| Armelin, HA; Armelin, MC; Kimura, E; Sonobe, MH | 1 |
| Beppu, T; Fujiwara, D; Horinouchi, S; Nishi, K; Nishikawa, M; Yoshida, M | 1 |
| Kahri, A; Liu, J; Teppo, AM; Voutilainen, R | 1 |
| Canalis, E; Rydziel, S; Shaikh, S | 1 |
| Larsen, TH; Lillehaug, JR; Myking, O; Saetersdal, T | 1 |
| Mitchell, R; Thomson, FJ | 1 |
| Mitchell, MD; Pollard, JK | 1 |
| Davis, BB; Thomas, DJ; Zenser, TV | 1 |
| Kim, HD; Lim, RW; Park, DJ | 1 |
| Beyaert, R; Boone, E; De Valck, D; Fiers, W; Haegeman, G; Heyninck, K; Schulze-Osthoff, K; Van Roy, F; Vanhaesebroeck, B | 1 |
| Matsui, T; Yamaguchi, M | 2 |
| Hayashi, Y; Mutoh, N; Nakagawa, CW | 1 |
| Chatterjee, D; Early, J; Han, Z; Hendrickson, EA; Pantazis, P; Wyche, JH | 1 |
| Iversen, PO; Lopez, AF; To, LB | 1 |
| Meikrantz, W; Schlegel, R | 1 |
| Bali, JP; Combettes, S; Hollande, F; Magous, R | 1 |
| Russev, G; Tsvetkov, L | 1 |
| Jacobsen, MD; Raff, MC; Weil, M | 1 |
| Coles, HS; Davies, TJ; Gardner, RL; Jacobson, MD; Raff, KD; Raff, MC; Weil, M | 1 |
| Misra, UK; Pizzo, SV | 1 |
| Bar-Shalom, I; Beery, R; Geier, A; Haimsohn, M; Hemi, R; Karasik, A; Lunenfeld, B; Malik, Z | 1 |
| Benahmed, M; Kolodié, L; Le Magueresse-Battistoni, B; Pernod, G | 1 |
| Pommier, Y; Shao, RG; Shimizu, T | 2 |
| Baldwin, AS; Mayo, MW; Wang, CY | 1 |
| Cockram, CS; Ho, SK; Nicholls, MG; Tsang, DS; Yeung, VT | 1 |
| Cao, L; Gardner, DG; Wu, J; Zlock, DW | 1 |
| Benahmed, M; Kolodié, L; Le Magueresse-Battistoni, B; Morera, AM; Pernod, G | 1 |
| Cory, S; Huang, DC; Strasser, A | 1 |
| Behrens, MI; Choi, DW; Koh, JY; Muller, MC | 1 |
| Fukuda, Y | 1 |
| Atkins, KB; Simpson, RU; Somerman, MJ | 1 |
| Higashiyama, S; Ito, N; Kawata, S; Kiso, S; Matsuzawa, Y; Nakagawa, T; Tamura, S; Taniguchi, N; Tsushima, H | 1 |
| Appleton, S; Edmonds, B; James, R; Medina, V; Young, GP; Zalewski, PD | 1 |
| Canzoniero, LM; Choi, DW; Dugan, LL; Farhangrazi, ZS; Gwag, BJ; Sensi, SL; Tian, M; Yeh, CH; Ying, HS; Yu, SP | 1 |
| Gschwendt, M; Kittstein, W; Krammer, PH; Möller, P; Sträter, J; von Reyher, U | 1 |
| Haapajärvi, T; Laiho, M; Pitkänen, K | 1 |
| Harnett, MM; Houslay, MD; Michie, AM; Rena, G | 1 |
| David, M; Mowen, K; Navarro, L; Reich, N; Rodems, S; Spector, D; Weaver, B | 1 |
| Berger, S; León, J; Rojo, E; Sánchez-Serrano, JJ; Titarenko, E; Vancanneyt, G | 1 |
| Brennand, JE; Calder, AA; Greer, IA; Kelly, RW; Leask, R | 1 |
| Jacobson, MD; Raff, MC; Weil, M | 1 |
| McCumbee, WD; Quinn, LA | 1 |
| Kamp, DW; Panos, RJ; Pollack, N; Sporn, PH; Wu, KI | 1 |
| Huh, SO; Kim, YH; Lee, JK; Lee, KJ; Song, DK; Suh, HW; Won, JS | 1 |
| Kidd, VJ; Tang, D | 1 |
| Adachi, K; Hirata, Y; Kiuchi, K | 1 |
| Adams, GE; Hasan, NM; Joiner, MC | 1 |
| Gebert, CA; Park, SH; Waxman, DJ | 1 |
| Guo, ZG; Niu, XL; Zhang, XW | 1 |
| Luo, W; Vik, DP | 1 |
| Chang, II; Choi, WS; Kim, JE; Krajewski, S; O'Malley, KL; Oh, JH; Oh, YJ; Reed, JC; Sohn, S | 1 |
| Morita, H; Ohuchi, K; Someya, K; Takahashi, K; Xiao, YQ | 1 |
| Chaqour, B; Howard, PS; Macarak, EJ; Richards, CF | 1 |
| Canzoniero, LM; Choi, WS; Gwag, BJ; Kim, JE; Lee, EB; O'Malley, KL; Oh, TH; Oh, YJ; Sensi, SL; Sohn, S | 1 |
| Amendola, A; Oliverio, S; Piacentini, M; Rodolfo, C; Spinedi, A | 1 |
| Behrens, MM; Choi, DW; Gwag, BJ; Koh, JY; Strasser, U | 1 |
| Amara, SG; Daniels, GM | 1 |
| Dudler, R; Freydl, E; Granado, J; Hassa, P; Wäspi, U | 1 |
| Hill, IE; MacManus, JP; Murray, C; Rasquinha, I; Richard, J | 1 |
| Keogh, SA; Martin, SJ; Slee, EA | 1 |
| Hazama, A; Ishizaki, Y; Kanaseki, T; Maeno, E; Okada, Y | 1 |
| Agrawal, GK; Jwa, NS; Rakwal, R | 1 |
| Hara, K; Koizumi, N; Kusano, T; Sano, H; Yagi, M | 1 |
| Hallikas, O; Hildén, P; Kuismanen, E; Määttä, J; Schröder, J; Welti, S | 1 |
| Büssing, A; Pfüller, U; Schietzel, M; Stein, GM | 1 |
| Baireddy, V; Strayer, DS; White, MK | 1 |
| Bass, BL; Li, L; Rao, JN; Wang, JY | 1 |
| Byun, Y; Chang, R; Chen, F; Cryns, VL; Green, KJ; Trivedi, M | 1 |
| Chen, HJ; Hou, WC; Kuć, J; Lin, YH | 1 |
| Fong, WF; Lam, W; Leung, CH; Wong, NS; Yang, MS; Zhuang, WJ | 1 |
| Calabrese, EJ | 1 |
| Ahlemeyer, B; Becker, A; Klumpp, S; Krieglstein, J; Ravati, A | 1 |
| Düssmann, H; Kögel, D; Luetjens, CM; Nieminen, AL; Poppe, M; Prehn, JH; Reimertz, C; Renz, A; Schulze-Osthoff, K | 1 |
| Igarashi, A; Yamaguchi, M | 1 |
| Kabir, J; Lobo, M; Zachary, I | 1 |
| Chang, YC; Hsieh, YS; Lai, CC; Liu, JY; Yang, SF | 1 |
| Gimbrone, MA; Masuda, J; Ochi, H | 1 |
| Cohn, JA; Farber, JL; Karpinich, NO; Rothman, RJ; Russo, MA; Tafani, M | 1 |
| Bradbury, ME; Nishi, K; Schnier, JB | 1 |
| Coleman, MP; Conforti, L; Perry, VH; Platt, N; Sievers, C | 1 |
| Ardini, E; Kelleher, DP; Terrés, AM; Windle, HJ | 1 |
| Chain, BM; Cho, JY; Katz, DR | 1 |
| Cho, KS; Kang, KY; Kang, SY; Kim, SG; Kim, ST | 1 |
| Busch, CR; Heath, DD; Hubberstey, A | 1 |
| Hu, YX; Li, JY; Liu, XF; Wang, YX | 1 |
| Ando, K; Chang, YC; Magae, J; Nakajima, H; Ozawa, S; Togashi, M; Tsuruga, M | 1 |
| Lockshin, RA; Negron, JF | 1 |
| Andreka, P; Bishopric, NH; Evans, WH; Haywood, GA; Martin, PE; Turner, MS; Webster, KA; You, L | 1 |
| Alberghina, M; Anfuso, CD; Assero, G; Cannavò, G; Lupo, G; Nicotra, A; Pluta, R; Rapisarda, P; Strosznajder, RP | 1 |
| Chiao, P; Su, H; Xiao, Y; Zhong, G; Zhong, Y; Zhou, Z | 1 |
| Koike, T; Suzuki, M | 1 |
| Eley, A; Geary, I; Hakimi, H; Hosseinzadeh, S; Pacey, AA | 1 |
| Inomata, H; Kakinuma, H; Kitamura, N | 1 |
| Erhardt, NM; Haines, LR; Pearson, TW; Sherwood, NM | 1 |
| Gajkowska, B; Orzechowski, A; Pajak, B | 1 |
| Duckett, CS; Gélinas, C; Kucharczak, JF; Simmons, MJ | 1 |
| Brecht, K; Heim, J; Simonen, M | 1 |
| Bell, CW; Jiang, W; Pisetsky, DS; Reich, CF | 1 |
| Checler, F; Cisse, MA; da Costa, CA; Sunyach, C; Vincent, B | 1 |
| Mannherz, HG; Mazur, A; Meller, K; Theiss, C | 1 |
| Christensen, ST; Hoffmann, EK; Schneider, L; Schou, KB | 1 |
| Baillie, L; Basu, S; Cross, AS; Kang, TJ; Thomas, KE; Vogel, SN; Zhang, L | 1 |
| Ballatori, N; Hammond, CL; Marchan, R | 1 |
| Cohen, IS; Doronin, SV; Potapova, IA | 1 |
| Binge, LC; Gurung, R; Hakim, S; Horan, KA; Ivetac, I; Majerus, PW; Mitchell, CA; Sheffield, DA; Tiganis, T | 1 |
1 review(s) available for cycloheximide and staurosporine
| Article | Year |
|---|---|
Apoptosis: biphasic dose responses.
Topics: Animals; Antioxidants; Apoptosis; Cycloheximide; Dementia; Dimethylformamide; Dose-Response Relationship, Drug; Enzyme Inhibitors; Homeostasis; Humans; Melatonin; Necrosis; Nootropic Agents; Protein Synthesis Inhibitors; Radiation Injuries; Staurosporine; Tacrine; Tumor Necrosis Factor-alpha | 2001 |
160 other study(ies) available for cycloheximide and staurosporine
| Article | Year |
|---|---|
Yeast glycogen synthase kinase-3beta pathway inhibitors from an organic extract of Streptomyces sp.
Topics: Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Imides; Molecular Structure; Saccharomyces cerevisiae; Streptomyces; Thiadiazoles | 2009 |
Imaging of Plasmodium liver stages to drive next-generation antimalarial drug discovery.
Topics: Animals; Antimalarials; Cell Line, Tumor; Drug Discovery; Drug Evaluation, Preclinical; Drug Resistance; Erythrocytes; Humans; Imidazoles; Liver; Malaria; Mice; Mice, Inbred BALB C; Molecular Structure; Piperazines; Plasmodium; Plasmodium berghei; Plasmodium falciparum; Plasmodium yoelii; Polymorphism, Single Nucleotide; Protozoan Proteins; Random Allocation; Small Molecule Libraries; Sporozoites | 2011 |
Melleolides induce rapid cell death in human primary monocytes and cancer cells.
Topics: Apoptosis; Cell Survival; Cells, Cultured; HeLa Cells; Humans; K562 Cells; Microscopy; Monocytes; Oligopeptides; Staurosporine; Structure-Activity Relationship | 2014 |
Preussilides A-F, Bicyclic Polyketides from the Endophytic Fungus Preussia similis with Antiproliferative Activity.
Topics: Anti-Infective Agents; Humans; Magnetic Resonance Spectroscopy; Molecular Structure; Penicillium; Phylogeny; Polyketides | 2017 |
Caspase-Dependent Apoptosis in Prostate Cancer Cells and Zebrafish by Corchorusoside C from Streptocaulon juventas.
Topics: Animals; Antineoplastic Agents, Phytogenic; Apocynaceae; Apoptosis; Caspases; Cell Line, Tumor; Humans; I-kappa B Kinase; Male; Molecular Structure; Poly (ADP-Ribose) Polymerase-1; Prostate; Prostatic Neoplasms; Proto-Oncogene Proteins c-bcl-2; Pyrans; Vietnam; Zebrafish | 2019 |
Phorbol esters differentially regulate the expression of insulin-like growth factor-binding proteins in endometrial carcinoma cells.
Topics: Adenocarcinoma; Alkaloids; Blotting, Northern; Calcimycin; Carrier Proteins; Cell Division; Cycloheximide; Endometrial Neoplasms; Enzyme Activation; Female; Gene Expression Regulation; Humans; Insulin-Like Growth Factor Binding Proteins; Kinetics; Protein Kinase C; RNA, Messenger; Staurosporine; Terpenes; Tetradecanoylphorbol Acetate; Thapsigargin; Tumor Cells, Cultured | 1992 |
Homologous desensitization of HEL cell thrombin receptors. Distinguishable roles for proteolysis and phosphorylation.
Topics: Alkaloids; Amino Acid Sequence; Calcium; Cell Line; Cycloheximide; Cytosol; Humans; Inositol; Inositol Phosphates; Kinetics; Leukemia; Molecular Sequence Data; Oligopeptides; Pertussis Toxin; Phosphatidylinositols; Phosphorylation; Protein Kinase C; Receptors, Cell Surface; Receptors, Thrombin; Staurosporine; Thrombin; Virulence Factors, Bordetella | 1992 |
Protein kinase C activity is rate limiting for shedding of the interleukin-6 receptor.
Topics: Alkaloids; Animals; Binding Sites; Carcinoma, Hepatocellular; Cell Line; Cycloheximide; Humans; Interleukin-6; Kinetics; Liver Neoplasms; Macromolecular Substances; Phorbol Esters; Protein Kinase C; Receptors, Immunologic; Receptors, Interleukin-6; Recombinant Proteins; Staurosporine; Transfection; Tumor Cells, Cultured | 1992 |
A novel IgA receptor expressed on a murine B cell lymphoma.
Topics: Alkaloids; Animals; Binding, Competitive; Cycloheximide; Down-Regulation; Hydrogen-Ion Concentration; Immunoglobulin A; Immunoglobulin G; Immunoglobulin M; In Vitro Techniques; Ionomycin; Lymphocyte Activation; Lymphoma, B-Cell; Mice; Mice, Inbred BALB C; Naphthalenes; Phosphatidylinositol Diacylglycerol-Lyase; Phosphoinositide Phospholipase C; Phosphoric Diester Hydrolases; Polycyclic Compounds; Protein Kinase C; Receptors, Fc; Receptors, Immunologic; Rosette Formation; Secretory Component; Staurosporine; Tetradecanoylphorbol Acetate; Trypsin; Tumor Cells, Cultured | 1992 |
Involvement of tyrosine kinase and protein kinase C in platelet-activating-factor-induced c-fos gene expression in A-431 cells.
Topics: Alkaloids; Blotting, Northern; Cinnamates; Colforsin; Cycloheximide; Gene Expression; Genes, fos; Genistein; Humans; Isoflavones; Platelet Activating Factor; Protein Kinase C; Protein-Tyrosine Kinases; RNA; Staurosporine; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1992 |
Rapid regulation of albumin transcription by insulin and phorbol esters in rat hepatoma cells.
Topics: Albumins; Alkaloids; Animals; Cycloheximide; Gene Expression Regulation; Insulin; Kinetics; Liver Neoplasms, Experimental; Naphthalenes; Phosphoenolpyruvate Carboxykinase (GTP); Polycyclic Compounds; Protein Kinase C; Rats; Staurosporine; Tetradecanoylphorbol Acetate; Transcription, Genetic; Tumor Cells, Cultured | 1992 |
Apoptosis in metanephric development.
Topics: Alkaloids; Animals; Apoptosis; Cycloheximide; Dactinomycin; Embryonic Induction; Epidermal Growth Factor; Epidermis; Mesoderm; Nephrons; Organ Culture Techniques; Phorbol Esters; Protein Kinase C; Rats; Spinal Cord; Staurosporine; Ureter | 1992 |
Transcriptional activation of c-fos and c-jun protooncogenes by serum growth factors in osteoblast-like MC3T3-E1 cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 3T3 Cells; Alkaloids; Animals; Cell Differentiation; Cycloheximide; Dactinomycin; Epidermal Growth Factor; Fibroblast Growth Factor 2; Gene Expression Regulation; Growth Substances; Insulin-Like Growth Factor I; Isoquinolines; Mice; Osteoblasts; Piperazines; Platelet-Derived Growth Factor; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-fos; Proto-Oncogene Proteins c-jun; Proto-Oncogenes; RNA, Messenger; Staurosporine; Transforming Growth Factor beta | 1992 |
Role of protein kinase C activity in tumor necrosis factor-alpha gene expression. Involvement at the transcriptional level.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Astrocytes; Base Sequence; Cycloheximide; Dose-Response Relationship, Drug; Gene Expression Regulation; Interferon-gamma; Interleukin-1; Isoquinolines; Lipopolysaccharides; Molecular Sequence Data; Piperazines; Protein Kinase C; Protein Kinase Inhibitors; Rats; RNA, Messenger; Second Messenger Systems; Staurosporine; Time Factors; Transcription, Genetic; Tumor Necrosis Factor-alpha | 1992 |
Differential effects of phorbol esters on proliferation and calcyclin expression in human endometrial carcinoma cells.
Topics: Adenocarcinoma; Alkaloids; Calcimycin; Calcium-Binding Proteins; Cell Cycle Proteins; Cell Division; Cycloheximide; Enzyme Activation; Female; Gene Expression Regulation, Neoplastic; Humans; Neoplasm Proteins; Phorbol 12,13-Dibutyrate; Phorbol Esters; Protein Kinase C; RNA, Messenger; RNA, Neoplasm; S100 Calcium Binding Protein A6; S100 Proteins; Signal Transduction; Staurosporine; Terpenes; Tetradecanoylphorbol Acetate; Thapsigargin; Uterine Neoplasms | 1992 |
Priming of human polymorphonuclear leukocytes with granulocyte-macrophage colony-stimulating factor involves protein kinase C rather than enhanced calcium mobilisation.
Topics: Alkaloids; Arachidonate 5-Lipoxygenase; Arachidonic Acid; Calcium; Cations, Divalent; Chromatography, High Pressure Liquid; Cycloheximide; Dactinomycin; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; Ionomycin; Leukotrienes; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Phospholipases A; Phospholipases A2; Protein Kinase C; Recombinant Proteins; Staurosporine; Tetradecanoylphorbol Acetate | 1992 |
Role of protein phosphorylation in activation of interferon-stimulated gene factors.
Topics: 2-Aminopurine; Alkaloids; Base Sequence; Cell Nucleus; Cycloheximide; DNA-Binding Proteins; HeLa Cells; Humans; Interferon-alpha; Interferon-gamma; Interferon-Stimulated Gene Factor 3; Interferon-Stimulated Gene Factor 3, alpha Subunit; Interferon-Stimulated Gene Factor 3, gamma Subunit; Macromolecular Substances; Models, Biological; Molecular Sequence Data; Oligodeoxyribonucleotides; Phosphorylation; Protein Kinase C; Protein Kinase Inhibitors; Protein Kinases; RNA, Messenger; Staurosporine; Tetradecanoylphorbol Acetate; Transcription Factors; Transcription, Genetic | 1992 |
Effect of 25-hydroxycholesterol on cholesteryl ester formation in Caco-2 cells.
Topics: Alkaloids; Cell Line; Cholesterol Esters; Cycloheximide; Dactinomycin; Humans; Hydroxycholesterols; Intestinal Mucosa; Intestines; Kinetics; Microsomes; Protein Kinase C; Staurosporine; Sterol O-Acyltransferase | 1992 |
Mechanism of collagen phagocytosis by human gingival fibroblasts: importance of collagen structure in cell recognition and internalization.
Topics: Alkaloids; Amino Acid Sequence; Binding Sites; Cell Adhesion; Collagen; Cycloheximide; Enzyme Induction; Fibroblasts; Gingiva; Glycoproteins; Humans; Metalloendopeptidases; Microbial Collagenase; Molecular Sequence Data; Oligopeptides; Phagocytosis; Protein Conformation; Staurosporine; Tissue Inhibitor of Metalloproteinases | 1991 |
Phorbol ester-mediated inhibition of IFN-alpha/beta gene transcription in blood mononuclear leukocytes.
Topics: Alkaloids; Blotting, Northern; Cells, Cultured; Cycloheximide; Diglycerides; Gene Expression; Herpes Simplex; Humans; In Vitro Techniques; Interferon-alpha; Interferon-beta; Leukocytes, Mononuclear; Parainfluenza Virus 1, Human; Paramyxoviridae Infections; Protein Kinase C; RNA, Messenger; Simplexvirus; Staurosporine; Tetradecanoylphorbol Acetate; Transcription, Genetic | 1991 |
Fibroblast growth factor-dependent mitogenic signal transduction pathway in chemically transformed mouse fibroblasts is similar to but distinct from that initiated by phorbol esters.
Topics: 1-Methyl-3-isobutylxanthine; Alkaloids; Animals; Cell Cycle; Cycloheximide; DNA-Binding Proteins; Fibroblast Growth Factors; Mice; Phorbol Esters; Protein Kinase C; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-fos; Proto-Oncogene Proteins c-jun; Signal Transduction; Staurosporine; Transcription Factors; Tubulin | 1990 |
Acidic and basic fibroblast growth factors are survival factors with distinctive activity in quiescent BALB/c 3T3 murine fibroblasts.
Topics: Alkaloids; Animals; Cell Line; Cell Survival; Culture Media; Cycloheximide; DNA Damage; Fibroblast Growth Factor 1; Fibroblast Growth Factor 2; Heparin; In Vitro Techniques; Mice; Nucleosomes; Platelet-Derived Growth Factor; RNA; Staurosporine | 1991 |
Regulation of prostaglandin H synthase activity in dog urothelial cells.
Topics: Alkaloids; Animals; Arachidonic Acid; Aspirin; Cells, Cultured; Cycloheximide; Dinoprostone; Dogs; Prostaglandin-Endoperoxide Synthases; Staurosporine; Tetradecanoylphorbol Acetate; Urinary Bladder | 1992 |
Role of [Ca2+]i in induction of c-fos, c-jun, and c-myc mRNA in rat PTE after oxidative stress.
Topics: Alkaloids; Animals; Benzamides; Blotting, Northern; Calcium; Catalase; Cell Hypoxia; Cycloheximide; Dose-Response Relationship, Drug; Gene Expression Regulation; Genes, fos; Genes, jun; Genes, myc; In Vitro Techniques; Ionomycin; Kidney Tubules; Male; Protein Kinase C; Rats; Rats, Inbred F344; RNA, Messenger; Staurosporine; Superoxide Dismutase; Tetradecanoylphorbol Acetate; Time Factors; Transcription, Genetic; Xanthine; Xanthines | 1992 |
Activation of IFN-beta element by IRF-1 requires a posttranslational event in addition to IRF-1 synthesis.
Topics: Alkaloids; Animals; Base Sequence; Blotting, Western; Cell Line; Cycloheximide; DNA-Binding Proteins; Gene Expression Regulation; Interferon Regulatory Factor-1; Interferon Regulatory Factor-2; Interferon Type I; Mice; Molecular Sequence Data; Newcastle disease virus; Phosphoproteins; Precipitin Tests; Promoter Regions, Genetic; Protein Processing, Post-Translational; Repetitive Sequences, Nucleic Acid; Repressor Proteins; Staurosporine; Transcription Factors; Tumor Necrosis Factor-alpha | 1991 |
Modulation of platelet-derived growth factor A- and B-chain/c-sis mRNA by tumor necrosis factor and other agents in adenocarcinoma cells.
Topics: Adenocarcinoma; Alkaloids; Blotting, Northern; Cell Line; Cycloheximide; Dose-Response Relationship, Drug; Humans; Interferon-gamma; Pancreatic Neoplasms; Platelet-Derived Growth Factor; Protein Kinase C; Protein Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-sis; RNA, Messenger; Signal Transduction; Staurosporine; Time Factors; Tumor Necrosis Factor-alpha | 1991 |
Endotoxin-induced arachidonic acid metabolism requires de novo protein synthesis and protein kinase C activation.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Arachidonic Acid; Arachidonic Acids; Bacterial Toxins; Calcimycin; Camptothecin; Cell Survival; Cells, Cultured; Cycloheximide; Dactinomycin; Endotoxins; Enterotoxins; Enzyme Activation; Isoquinolines; Macrophages; Male; Piperazines; Protein Biosynthesis; Protein Kinase C; Rats; Staurosporine; Tetradecanoylphorbol Acetate; Thromboxane B2 | 1991 |
Protein kinase-C activation is required for oxytocin-induced prostaglandin production in human amnion cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Amnion; Calcium; Cells, Cultured; Cycloheximide; Dactinomycin; Dinoprostone; Enzyme Activation; Epidermal Growth Factor; Female; Humans; Isoquinolines; Oxytocin; Phorbol Esters; Piperazines; Pregnancy; Protein Kinase C; RNA, Messenger; Staurosporine; Time Factors; Type C Phospholipases | 1991 |
Staurosporine-induced morphological differentiation of human neuroblastoma cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Axons; Cell Differentiation; Colchicine; Cycloheximide; Humans; Isoquinolines; Microtubules; Neuroblastoma; Neurons; Phosphorylation; Piperazines; Protein Kinase Inhibitors; Protein Kinases; Staurosporine; Sulfonamides; Tumor Cells, Cultured | 1991 |
Histidine decarboxylase in human basophilic leukemia (KU-812-F) cells. Characterization and induction by phorbol myristate acetate.
Topics: Alkaloids; Calcimycin; Carboxy-Lyases; Cycloheximide; Enzyme Induction; Histidine Decarboxylase; Humans; Leukemia, Basophilic, Acute; Protein Kinase C; Staurosporine; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1990 |
Dual effects of staurosporine on arachidonic acid metabolism in rat peritoneal macrophages.
Topics: Alkaloids; Animals; Arachidonic Acid; Arachidonic Acids; Calcium; Carcinogens; Cycloheximide; Dinoprostone; Dose-Response Relationship, Drug; Kinetics; Macrophages; Peritoneal Cavity; Rats; Rats, Inbred Strains; Staurosporine; Tetradecanoylphorbol Acetate | 1990 |
Protein kinase C and the stimulation of tissue plasminogen activator release from human endothelial cells. Dependence on the elevation of messenger RNA.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Blotting, Northern; Calcium Channel Blockers; Cells, Cultured; Cloning, Molecular; Colforsin; Cycloheximide; DNA; Endothelium, Vascular; Humans; Isoquinolines; Kinetics; Piperazines; Protein Kinase C; RNA, Messenger; Staurosporine; Sulfonamides; Tetradecanoylphorbol Acetate; Tissue Plasminogen Activator | 1989 |
The augmentation of insulin-like growth factor-I messenger ribonucleic acid in cultured rat hepatocytes: activation of protein kinase-A and -C is necessary, but not sufficient.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 1-Methyl-3-isobutylxanthine; Alkaloids; Animals; Blotting, Northern; Bucladesine; Cattle; Cells, Cultured; Cyclic AMP-Dependent Protein Kinases; Cycloheximide; Drug Synergism; Enzyme Activation; Glucagon; Growth Hormone; Insulin-Like Growth Factor I; Isoquinolines; Kinetics; Liver; Male; Piperazines; Protein Kinase C; Rats; Rats, Sprague-Dawley; RNA, Messenger; Sphingosine; Staurosporine; Tetradecanoylphorbol Acetate | 1994 |
Involvement of protein kinase A and C in the production of interleukin-1 alpha-induced prostaglandin E2 from mouse osteoblast-like cell line, MC3T3-E1.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 1-Methyl-3-isobutylxanthine; 3T3 Cells; 8-Bromo Cyclic Adenosine Monophosphate; Alkaloids; Animals; Carbazoles; Cyclic AMP-Dependent Protein Kinases; Cycloheximide; Dinoprostone; Humans; Indoles; Indomethacin; Interleukin-1; Isoquinolines; Kinetics; Mice; Osteoblasts; Piperazines; Protein Kinase C; Pyrroles; Recombinant Proteins; Signal Transduction; Staurosporine; Tetradecanoylphorbol Acetate | 1994 |
Cell cycle-specific induction of an 89 kDa serine/threonine protein kinase activity in Trypanosoma brucei.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Catechols; Cell Cycle; Cell Division; Cycloheximide; DNA; Enzyme Induction; Ethers, Cyclic; Flow Cytometry; Genistein; Isoflavones; Isoquinolines; Molecular Weight; Nitriles; Okadaic Acid; Phosphoproteins; Phosphorylation; Phosphotyrosine; Piperazines; Protein Denaturation; Protein Kinase C; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; S Phase; Staurosporine; Trypanosoma brucei brucei; Tyrosine; Tyrphostins | 1994 |
Cisplatin resistance in a murine leukemia cell line is associated with a defective apoptotic process.
Topics: Alkaloids; Animals; Apoptosis; Azacitidine; Cell Division; Cell Nucleus; Cisplatin; Clone Cells; Cycloheximide; DNA, Neoplasm; Drug Resistance; Endonucleases; Leukemia L1210; Mice; Microscopy, Confocal; Microscopy, Electron; Protein Kinase C; Staurosporine; Tumor Cells, Cultured | 1995 |
Inhibition of the arachidonic acid pathway prevents induction of IL-8 mRNA by phorbol ester and changes the release of IL-8 from HL 60 cells: differential inhibition of induced expression of IL-8, TNF-alpha, IL-1 alpha, and IL-1 beta.
Topics: 5,8,11,14-Eicosatetraynoic Acid; Acetophenones; Alkaloids; Arachidonic Acid; Cycloheximide; Cyclooxygenase Inhibitors; Dinoprostone; Enzyme Inhibitors; Gene Expression; HL-60 Cells; Humans; In Vitro Techniques; Inflammation Mediators; Interleukin-1; Interleukin-8; Leukotriene B4; Lipoxygenase Inhibitors; Phospholipases A; Protein Kinase C; Protein Synthesis Inhibitors; RNA, Messenger; Staurosporine; Tetradecanoylphorbol Acetate; Tumor Necrosis Factor-alpha | 1995 |
Cloning, characterization and expression of two Xenopus bcl-2-like cell-survival genes.
Topics: Alkaloids; Amino Acid Sequence; Animals; Apoptosis; bcl-X Protein; Cells, Cultured; Cloning, Molecular; Culture Media, Serum-Free; Cycloheximide; Fibroblasts; Genes, Regulator; Molecular Sequence Data; Morphogenesis; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Proto-Oncogene Proteins c-myc; Proto-Oncogenes; Recombinant Proteins; Sequence Homology, Amino Acid; Staurosporine; Tissue Distribution; Xenopus laevis; Xenopus Proteins | 1995 |
Cyclic AMP-independent up-regulation of the human serotonin transporter by staurosporine in choriocarcinoma cells.
Topics: Alkaloids; Carrier Proteins; Cholera Toxin; Choriocarcinoma; Cocaine; Cyclic AMP; Cyclic GMP; Cycloheximide; Dactinomycin; Female; Humans; Isoquinolines; Membrane Glycoproteins; Membrane Transport Proteins; Nerve Tissue Proteins; Pregnancy; RNA, Messenger; Serotonin; Serotonin Plasma Membrane Transport Proteins; Staurosporine; Sulfonamides; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Up-Regulation | 1995 |
Inhibitors of cGMP-dependent protein kinase block senescence induced by inactivation of T antigen in SV40-transformed immortal human fibroblasts.
Topics: Alkaloids; Antigens, Polyomavirus Transforming; Biomarkers; Carbazoles; Cell Line, Transformed; Cell Nucleus; Cell Transformation, Neoplastic; Cellular Senescence; Cyclic AMP-Dependent Protein Kinases; Cyclic GMP-Dependent Protein Kinases; Cycloheximide; Fibroblasts; Heat-Shock Proteins; HSP70 Heat-Shock Proteins; Humans; Immunohistochemistry; Indoles; Isoquinolines; Mitochondrial Proteins; Myosin-Light-Chain Kinase; Protein Kinase C; Signal Transduction; Simian virus 40; Staurosporine; Sulfonamides | 1995 |
Phorbol ester stimulated cathepsin L expression in U937 cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Cathepsin L; Cathepsins; Cell Differentiation; Cycloheximide; Cysteine Endopeptidases; Drug Interactions; Endopeptidases; Enzyme Induction; Humans; Isoquinolines; Lymphoma, Large B-Cell, Diffuse; Monocytes; Neoplasm Proteins; Piperazines; Protein Kinase C; Staurosporine; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Vanadates | 1995 |
Regulation of cytokine-stimulated vascular cell adhesion molecule-1 expression in renal tubular epithelial cells.
Topics: Alkaloids; Animals; Cell Adhesion Molecules; Cycloheximide; Dactinomycin; Dose-Response Relationship, Drug; Enzyme Activation; Epithelium; Female; Kidney Tubules; Mice; Mice, Inbred C3H; Protein Kinase C; RNA, Messenger; Staurosporine; Tetradecanoylphorbol Acetate; Tumor Necrosis Factor-alpha; Up-Regulation; Vascular Cell Adhesion Molecule-1 | 1993 |
Regulation of the TNF-alpha receptor in human osteosarcoma cells: role of microtubules and of protein kinase C.
Topics: Alkaloids; Cell Membrane; Cycloheximide; Ethers, Cyclic; Humans; Kinetics; Microtubules; Naphthalenes; Okadaic Acid; Osteosarcoma; Phosphoprotein Phosphatases; Polycyclic Compounds; Protein Kinase C; Receptors, Cell Surface; Receptors, Tumor Necrosis Factor; Staurosporine; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha; Vinblastine | 1993 |
Tumor necrosis factor increases stability of interleukin-1 mRNA by activating protein kinase C.
Topics: Alkaloids; Blotting, Western; Cycloheximide; Enzyme Activation; Humans; Interleukin-1; Kinetics; Naphthalenes; Polycyclic Compounds; Protein Kinase C; RNA, Messenger; Staurosporine; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha | 1993 |
Induction of nitric oxide synthase gene by interleukin in vascular smooth muscle cells.
Topics: Alkaloids; Amino Acid Oxidoreductases; Animals; Arginine; Base Sequence; Blotting, Northern; Calmodulin; Cells, Cultured; Cycloheximide; Dactinomycin; Dexamethasone; Dose-Response Relationship, Drug; Enzyme Induction; Interleukin-1; Molecular Sequence Data; Muscle, Smooth, Vascular; Nitric Oxide; Nitric Oxide Synthase; omega-N-Methylarginine; Polymerase Chain Reaction; Protein Kinase C; Rats; Recombinant Proteins; RNA, Messenger; Staurosporine; Sulfonamides | 1993 |
Basic fibroblast growth factor stimulates expression of interstitial collagenase and inhibitors of metalloproteinases in rat bone cells.
Topics: Alkaloids; Animals; Antibiotics, Antineoplastic; Blotting, Northern; Cells, Cultured; Collagenases; Cycloheximide; Dose-Response Relationship, Drug; Fetus; Fibroblast Growth Factor 2; Gene Expression; Glycoproteins; Indomethacin; Kinetics; Matrix Metalloproteinase 1; Osteoblasts; Protein Kinase C; Pyrimidine Nucleosides; Rats; Recombinant Proteins; RNA, Messenger; Staurosporine; Tetradecanoylphorbol Acetate; Time Factors; Tissue Inhibitor of Metalloproteinases; Transcription, Genetic | 1995 |
Evidence for the requirement of protein synthesis and protein kinase activity in the temperature regulated stability of a Tetrahymena surface protein mRNA.
Topics: Alkaloids; Animals; Antigens, Protozoan; Antigens, Surface; Cycloheximide; Phosphorylation; Protein Kinase Inhibitors; Protein Kinases; Protozoan Proteins; Puromycin; RNA, Messenger; RNA, Protozoan; Staurosporine; Temperature; Tetrahymena thermophila | 1995 |
Involvement of phospholipase C in heat-shock-induced phosphorylation of P-glycoprotein in multidrug resistant human breast cancer cells.
Topics: Alkaloids; ATP Binding Cassette Transporter, Subfamily B, Member 1; Breast Neoplasms; Cycloheximide; Diglycerides; Drug Resistance, Multiple; Estrenes; Hot Temperature; Humans; In Vitro Techniques; Inositol 1,4,5-Trisphosphate; Phosphorylation; Protein Kinase C; Pyrrolidinones; Staurosporine; Tumor Cells, Cultured; Type C Phospholipases | 1995 |
Effect of phorbol 12-myristate 13-acetate on hypoxanthine transport in LLC-PK1 renal epithelia.
Topics: Alkaloids; Animals; Biological Transport, Active; Cycloheximide; Epithelium; Hypoxanthine; Hypoxanthines; Kidney; Kinetics; LLC-PK1 Cells; Protein Kinase C; Sodium; Staurosporine; Swine; Tetradecanoylphorbol Acetate | 1994 |
Distinct morphological and mito-inhibitory effects induced by TGF-beta 1, HGF and EGF on mouse, rat and human hepatocytes.
Topics: Alkaloids; Animals; Cell Size; Cells, Cultured; Cycloheximide; Cytoskeletal Proteins; Cytoskeleton; DNA Replication; Dose-Response Relationship, Drug; Epidermal Growth Factor; Female; Genistein; Hepatocyte Growth Factor; Humans; Isoflavones; Liver; Male; Mice; Rats; Rats, Inbred F344; Staurosporine; Sulfonamides; Transforming Growth Factor beta | 1994 |
Staurosporine stimulates progesterone production by bovine placental cells.
Topics: Alkaloids; Animals; Calcium; Cattle; Cells, Cultured; Cycloheximide; Female; Genistein; Isoflavones; Kinetics; Placenta; Pregnancy; Progesterone; Protein Kinase Inhibitors; Protein Kinases; Staurosporine | 1994 |
Functional role of phosphorylation of the multidrug transporter (P-glycoprotein) by protein kinase C in multidrug-resistant MCF-7 cells.
Topics: Alkaloids; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cycloheximide; DNA, Complementary; Doxorubicin; Drug Resistance, Multiple; Drug Screening Assays, Antitumor; Humans; Phosphorylation; Protein Kinase C; Rats; Staurosporine; Tetradecanoylphorbol Acetate; Transfection; Tumor Cells, Cultured; Vinblastine | 1994 |
Prostaglandin E2/parathyroid hormone-induced suppression of alkaline phosphatase activity is mediated by protein kinase C.
Topics: Alkaline Phosphatase; Alkaloids; Animals; Bucladesine; Calcimycin; Cyclic AMP; Cycloheximide; Dinoprostone; Isoquinolines; Osteoblasts; Osteosarcoma; Parathyroid Hormone; Protein Kinase C; Rats; Staurosporine; Sulfonamides; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1994 |
Autocrine signals enable chondrocytes to survive in culture.
Topics: Aging; Alkaloids; Animals; Apoptosis; Biological Factors; Cartilage; Cell Survival; Cells, Cultured; Chick Embryo; Culture Media, Conditioned; Cycloheximide; Cysteine; Epithelial Cells; Epithelium; Fibroblast Growth Factor 2; Growth Substances; Humans; Insulin; Kinetics; Lens, Crystalline; Platelet-Derived Growth Factor; Protein Kinase C; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Staurosporine | 1994 |
Induction of FOS and JUN proteins by adrenocorticotropin and phorbol ester but not by 3',5'-cyclic adenosine monophosphate derivatives.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Adrenal Cortex; Adrenal Cortex Neoplasms; Adrenocorticotropic Hormone; Alkaloids; Animals; Bucladesine; Colforsin; Cycloheximide; Dactinomycin; Enzyme Induction; Genes, fos; Genes, jun; Kinetics; Mice; Neoplasm Proteins; Proto-Oncogene Proteins c-fos; Proto-Oncogene Proteins c-jun; RNA, Messenger; Signal Transduction; Staurosporine; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1993 |
Leptomycin B targets a regulatory cascade of crm1, a fission yeast nuclear protein, involved in control of higher order chromosome structure and gene expression.
Topics: Alkaloids; Alleles; Antifungal Agents; Chromosomes, Fungal; Cloning, Molecular; Cycloheximide; DNA, Fungal; Drug Resistance, Microbial; Exportin 1 Protein; Fatty Acids, Unsaturated; Fungal Proteins; Gene Expression Regulation, Fungal; Genes, Fungal; Karyopherins; Nuclear Proteins; Open Reading Frames; Point Mutation; Protein Kinase C; Receptors, Cytoplasmic and Nuclear; Restriction Mapping; Schizosaccharomyces; Staurosporine; TATA Box; Transcription Factors; Valinomycin | 1994 |
Regulation of parathyroid hormone gene expression and peptide secretion in human parathyroid cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenoma; Alkaloids; Base Sequence; Blotting, Northern; Calcium; Cell Division; Cycloheximide; Dose-Response Relationship, Drug; Gene Expression Regulation; Humans; Hyperparathyroidism; Isoquinolines; Molecular Sequence Data; Oligonucleotide Probes; Parathyroid Hormone; Parathyroid Neoplasms; Piperazines; RNA, Messenger; Staurosporine; Tetradecanoylphorbol Acetate; Time Factors; Tumor Cells, Cultured | 1994 |
Platelet-derived growth factor-AA and -BB (PDGF-AA and -BB) enhance the synthesis of PDGF-AA in bone cell cultures.
Topics: Alkaloids; Animals; Becaplermin; Blotting, Northern; Bone and Bones; Cells, Cultured; Culture Media; Cycloheximide; Gene Expression; Kinetics; Osteoblasts; Platelet-Derived Growth Factor; Protein Kinase C; Proto-Oncogene Proteins c-sis; Rats; RNA, Messenger; Staurosporine; Tetradecanoylphorbol Acetate | 1994 |
Inhibition and down-regulation of protein kinase C in cultured atrial myocytes: effects on distribution of specific granules and secretion of atrial natriuretic peptide.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Analysis of Variance; Animals; Atrial Natriuretic Factor; Cells, Cultured; Culture Media; Cycloheximide; Cytoplasmic Granules; Down-Regulation; Fluorescent Antibody Technique; Isoquinolines; Microscopy, Electron; Microtubules; Myocardium; Piperazines; Protein Kinase C; Radioimmunoassay; Rats; Staurosporine; Tetradecanoylphorbol Acetate | 1993 |
Differential involvement of phospholipase A2 in phorbol ester-induced luteinizing hormone and growth hormone release from rat anterior pituitary tissue.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Aminobenzoates; Animals; Arachidonic Acid; Aristolochic Acids; Chlorobenzoates; Cinnamates; Cyclohexanones; Cycloheximide; Enzyme Activation; Female; Growth Hormone; Indoles; Ionomycin; Isoquinolines; Luteinizing Hormone; Melitten; ortho-Aminobenzoates; Phenanthrenes; Phenothiazines; Phorbol 12,13-Dibutyrate; Phospholipases A; Phospholipases A2; Piperazines; Pituitary Gland, Anterior; Proestrus; Protein Kinase C; Quinacrine; Rats; Rats, Wistar; Signal Transduction; Staurosporine | 1993 |
Tumor necrosis factor alpha stimulates amnion prostaglandin biosynthesis primarily via an action on fatty acid cyclooxygenase.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Amnion; Arachidonic Acid; Aspirin; Cells, Cultured; Cycloheximide; Dactinomycin; Dinoprostone; Female; Humans; Isoquinolines; Piperazines; Pregnancy; Prostaglandin-Endoperoxide Synthases; Protein Kinase C; Staurosporine; Tetradecanoylphorbol Acetate; Tumor Necrosis Factor-alpha | 1993 |
Cyclic adenosine monophosphate response in primary and subcultured bladder epithelial cells: inhibition by 12-O-tetradecanoylphorbol-13-acetate.
Topics: 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Alkaloids; Animals; Calcimycin; Cells, Cultured; Colforsin; Cyclic AMP; Cycloheximide; Dogs; Dose-Response Relationship, Drug; Epidermal Growth Factor; Epithelial Cells; Epithelium; Indomethacin; Models, Biological; Protein Kinase C; Second Messenger Systems; Signal Transduction; Sphingosine; Staurosporine; Tetradecanoylphorbol Acetate; Urinary Bladder | 1993 |
Rapid induction of mouse virus-like (VL30) element transcripts by erythropoietin in murine erythroid progenitor cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Cloning, Molecular; Cycloheximide; DNA; DNA Transposable Elements; Erythroid Precursor Cells; Erythropoietin; Female; Friend murine leukemia virus; Gene Expression; Genistein; In Vitro Techniques; Isoflavones; Isoquinolines; Mice; Mice, Inbred BALB C; Piperazines; Protein Kinase C; Repetitive Sequences, Nucleic Acid; RNA, Messenger; Staurosporine; Time Factors; Transcription, Genetic; Tumor Cells, Cultured | 1993 |
Sensitization of tumor cells to tumor necrosis factor action by the protein kinase inhibitor staurosporine.
Topics: Alkaloids; Animals; Cycloheximide; Drug Synergism; Fibrosarcoma; Heat-Shock Proteins; HeLa Cells; Humans; Interleukin-6; Mice; Osteosarcoma; Phospholipase D; Phospholipases; Phosphorylation; RNA, Messenger; Staurosporine; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha | 1993 |
Zinc modulation of insulin-like growth factor's effect in osteoblastic MC3T3-E1 cells.
Topics: 3T3 Cells; Alkaline Phosphatase; Alkaloids; Animals; Carnosine; Cycloheximide; DNA; Drug Synergism; Enzyme Inhibitors; Ethers, Cyclic; Insulin; Insulin-Like Growth Factor I; Mice; Okadaic Acid; Organometallic Compounds; Osteoblasts; Protein Synthesis Inhibitors; Proteins; Staurosporine; Zinc; Zinc Compounds | 1995 |
Transcriptional regulation of catalase gene in the fission yeast Schizosaccharomyces pombe: molecular cloning of the catalase gene and northern blot analyses of the transcript.
Topics: Alkaloids; Amino Acid Sequence; Base Sequence; Blotting, Northern; Catalase; Cloning, Molecular; Cycloheximide; Enzyme Induction; Enzyme Inhibitors; Gene Expression Regulation, Fungal; Molecular Sequence Data; RNA, Messenger; Schizosaccharomyces; Staurosporine; Transcription, Genetic | 1995 |
Isolation and characterization of an apoptosis-resistant variant of human leukemia HL-60 cells that has switched expression from Bcl-2 to Bcl-xL.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Alkaloids; Apoptosis; Base Sequence; bcl-2-Associated X Protein; bcl-X Protein; Cycloheximide; HL-60 Cells; Humans; Molecular Sequence Data; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Staurosporine | 1996 |
Apoptosis of hemopoietic cells by the human granulocyte-macrophage colony-stimulating factor mutant E21R.
Topics: Acute Disease; Alkaloids; Apoptosis; Cell Division; Cell Survival; Cells, Cultured; Cycloheximide; Cytokines; Dactinomycin; Enzyme Inhibitors; Genistein; Granulocyte Colony-Stimulating Factor; Granulocyte-Macrophage Colony-Stimulating Factor; Hematopoietic Stem Cells; Humans; Interleukin-3; Isoflavones; Kinetics; Leukemia, Myeloid; Phosphorylation; Point Mutation; Protein Kinase C; Protein-Tyrosine Kinases; Reference Values; Staurosporine; Stem Cell Factor | 1996 |
Suppression of apoptosis by dominant negative mutants of cyclin-dependent protein kinases.
Topics: Alkaloids; Apoptosis; CDC2-CDC28 Kinases; Cyclin-Dependent Kinase 2; Cyclin-Dependent Kinase 3; Cyclin-Dependent Kinase 5; Cyclin-Dependent Kinases; Cyclins; Cycloheximide; Genes, Dominant; HeLa Cells; Humans; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Staurosporine; Tumor Necrosis Factor-alpha | 1996 |
Gastrin stimulation of histamine synthesis in enterochromaffin-like cells from rabbit fundic mucosa.
Topics: Alkaloids; Animals; Cells, Cultured; Cholera Toxin; Cycloheximide; Dactinomycin; Enzyme Inhibitors; Gastric Fundus; Gastric Mucosa; Gastrins; Gene Expression; Histamine; Histidine Decarboxylase; Kinetics; Pertussis Toxin; Polymyxin B; Protein Kinase C; Rabbits; RNA, Messenger; Staurosporine; Tetradecanoylphorbol Acetate; Virulence Factors, Bordetella | 1996 |
Decreased rates of replicon initiation in mammalian cells.
Topics: Alkaloids; Animals; Antineoplastic Agents; Benzamides; Cisplatin; Cycloheximide; DNA Replication; DNA, Neoplasm; Down-Regulation; Etoposide; Friend murine leukemia virus; Kinetics; Leukemia, Erythroblastic, Acute; Mice; Replicon; Signal Transduction; Staurosporine; Tumor Cells, Cultured | 1996 |
Role of Ced-3/ICE-family proteases in staurosporine-induced programmed cell death.
Topics: Alkaloids; Amino Acid Chloromethyl Ketones; Amino Acid Sequence; Animals; Apoptosis; Caenorhabditis elegans Proteins; Caspase 1; Caspase 3; Caspases; Cell Line; Cycloheximide; Cysteine Endopeptidases; Extremities; Helminth Proteins; Humans; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Molecular Sequence Data; Oligopeptides; Protease Inhibitors; Protein Kinase C; Protein Synthesis Inhibitors; Staurosporine | 1996 |
Constitutive expression of the machinery for programmed cell death.
Topics: Alkaloids; Animals; Animals, Newborn; Apoptosis; Blastocyst; Blastomeres; Cycloheximide; Enzyme Inhibitors; Erythrocytes; Female; Humans; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Organ Culture Techniques; Ovum; Protein Kinase Inhibitors; Protein Synthesis Inhibitors; Rats; Rats, Sprague-Dawley; Staurosporine | 1996 |
Ligation of the alpha 2-macroglobulin signaling receptor on macrophages induces synthesis of platelet activating factor.
Topics: 1-Alkyl-2-acetylglycerophosphocholine Esterase; Acetyltransferases; Alkaloids; alpha-Macroglobulins; Animals; Cells, Cultured; Choline; Cycloheximide; Low Density Lipoprotein Receptor-Related Protein-1; Macrophages; Mice; Mice, Inbred C57BL; Pertussis Toxin; Phospholipases A; Platelet Activating Factor; Protein Kinase C; Receptors, Immunologic; Specific Pathogen-Free Organisms; Staurosporine; Virulence Factors, Bordetella | 1996 |
Induction of apoptosis in MDA-231 cells by protein synthesis inhibitors is suppressed by multiple agents.
Topics: Alkaloids; Apoptosis; Breast Neoplasms; Cycloheximide; DNA; Epidermal Growth Factor; Female; Humans; Protein Biosynthesis; Protein Synthesis Inhibitors; Ricin; Staurosporine; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1996 |
Plasminogen activator inhibitor-1 regulation in cultured rat peritubular cells by basic fibroblast growth factor and transforming growth factor-alpha.
Topics: Animals; Cells, Cultured; Cycloheximide; Dactinomycin; Enzyme Inhibitors; Fibroblast Growth Factor 2; Kidney Tubules; Plasminogen Activator Inhibitor 1; Protein Kinase C; Rats; Recombinant Proteins; RNA, Messenger; Staurosporine; Tetradecanoylphorbol Acetate; Transforming Growth Factor alpha | 1996 |
Brefeldin A is a potent inducer of apoptosis in human cancer cells independently of p53.
Topics: Alkaloids; Antineoplastic Agents, Phytogenic; Apoptosis; Brefeldin A; Camptothecin; Cell-Free System; Cyclin B; Cyclin B1; Cyclins; Cycloheximide; Cyclopentanes; DNA Fragmentation; DNA, Neoplasm; Dose-Response Relationship, Drug; Enzyme Inhibitors; Etoposide; HL-60 Cells; HT29 Cells; Humans; Mutation; Protein Synthesis Inhibitors; Staurosporine; Time Factors; Tumor Suppressor Protein p53 | 1996 |
TNF- and cancer therapy-induced apoptosis: potentiation by inhibition of NF-kappaB.
Topics: Antibiotics, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Cell Nucleus; Cycloheximide; Daunorubicin; DNA-Binding Proteins; Humans; I-kappa B Proteins; Interleukin-1; Leupeptins; Neoplasms; NF-kappa B; NF-KappaB Inhibitor alpha; Protein Synthesis Inhibitors; Radiation, Ionizing; Staurosporine; Transcription Factor RelA; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha | 1996 |
Endothelin-3 attenuates the cyclic GMP responses to C-type natriuretic peptide in cultured mouse astrocytes.
Topics: Adenosine Diphosphate Ribose; Animals; Astrocytes; Atrial Natriuretic Factor; Binding, Competitive; Calcimycin; Calcium; Cells, Cultured; Cyclic GMP; Cycloheximide; Dose-Response Relationship, Drug; Endothelin-3; Enzyme Inhibitors; Indoles; Ionophores; Mice; Natriuretic Peptide, C-Type; Phospholipase D; Phospholipases A; Phosphoprotein Phosphatases; Protein Kinase C; Protein Synthesis Inhibitors; Protein-Tyrosine Kinases; Proteins; Staurosporine; Type C Phospholipases | 1996 |
Thrombin inhibits atrial natriuretic peptide receptor activity in cultured bovine endothelial cells.
Topics: Amino Acid Chloromethyl Ketones; Animals; Antithrombins; Aorta; Atrial Natriuretic Factor; Cattle; Cells, Cultured; Cycloheximide; Dose-Response Relationship, Drug; Down-Regulation; Endothelium, Vascular; Enzyme Inhibitors; Protein Kinase C; Protein Synthesis Inhibitors; Receptors, Atrial Natriuretic Factor; Receptors, Thrombin; Staurosporine; Tetradecanoylphorbol Acetate; Thrombin; Time Factors | 1997 |
Tumor necrosis factor-alpha regulates plasminogen activator inhibitor-1 in rat testicular peritubular cells.
Topics: Animals; Cells, Cultured; Cycloheximide; Dactinomycin; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; Genistein; Isoflavones; Male; Plasminogen Activator Inhibitor 1; Protein Synthesis Inhibitors; Rats; RNA, Messenger; Staurosporine; Testis; Tetradecanoylphorbol Acetate; Transforming Growth Factor alpha; Tumor Necrosis Factor-alpha; Up-Regulation | 1997 |
Bcl-2, Bcl-XL and adenovirus protein E1B19kD are functionally equivalent in their ability to inhibit cell death.
Topics: Adenovirus E1B Proteins; Animals; Antineoplastic Agents; Apoptosis; bcl-X Protein; Cell Cycle; Cell Line; Cell Survival; Cycloheximide; Cyclosporine; Dexamethasone; Gamma Rays; Humans; Interleukin-3; Jurkat Cells; Kinetics; Mice; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Recombinant Proteins; Staurosporine; Tetradecanoylphorbol Acetate; Time Factors; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha | 1997 |
Zinc enhancement of 17beta-estradiol's anabolic effect in osteoblastic MC3T3-E1 cells.
Topics: 3T3 Cells; Alkaline Phosphatase; Animals; Carnosine; Cell Count; Cells, Cultured; Cycloheximide; DNA; Drug Synergism; Enzyme Inhibitors; Estradiol; Iron Chelating Agents; Mice; Okadaic Acid; Organometallic Compounds; Osteoblasts; Picolinic Acids; Protein Kinase Inhibitors; Protein Synthesis Inhibitors; Proteins; Staurosporine; Zinc; Zinc Compounds; Zinc Sulfate | 1997 |
NADPH diaphorase-containing striatal or cortical neurons are resistant to apoptosis.
Topics: Animals; Apoptosis; Calcium Channel Blockers; Cells, Cultured; Cerebral Cortex; Corpus Striatum; Culture Media, Serum-Free; Cycloheximide; Enzyme Inhibitors; Mice; NADPH Dehydrogenase; Nerve Tissue Proteins; Neurons; Nimodipine; Nitro Compounds; Propionates; Protein Synthesis Inhibitors; Staurosporine | 1996 |
Interaction of tobacco nuclear protein with an elicitor-responsive element in the promoter of a basic class I chitinase gene.
Topics: Base Composition; Chitinases; Cycloheximide; DNA-Binding Proteins; Gene Expression Regulation, Plant; Genes, Plant; Nicotiana; Nuclear Proteins; Plant Proteins; Plants, Toxic; Promoter Regions, Genetic; Repetitive Sequences, Nucleic Acid; Staurosporine | 1997 |
Stimulation of osteopontin mRNA expression in HL-60 cells is independent of differentiation.
Topics: Alkaloids; Benzophenanthridines; Butyrates; Butyric Acid; Calcitriol; Cell Adhesion; Cell Adhesion Molecules; Cell Differentiation; Cycloheximide; Enzyme Inhibitors; Flavonoids; HL-60 Cells; Humans; Mitogen-Activated Protein Kinase Kinases; Osteopontin; Phenanthridines; Promoter Regions, Genetic; Protein Kinase C; Protein Kinase Inhibitors; Recombinant Proteins; RNA, Messenger; Sialoglycoproteins; Staurosporine; Tetradecanoylphorbol Acetate; Transcription, Genetic; Transfection; Tretinoin | 1997 |
Regulation of heparin-binding EGF-like growth factor expression by phorbol ester in a human hepatoma-derived cell line.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Carcinoma, Hepatocellular; Cycloheximide; Epidermal Growth Factor; Gene Expression Regulation; Heparin; Heparin-binding EGF-like Growth Factor; Humans; Intercellular Signaling Peptides and Proteins; Naphthalenes; Protein Kinase C; RNA, Messenger; Staurosporine; Tetradecanoylphorbol Acetate; Transcription, Genetic; Tumor Cells, Cultured | 1996 |
7-Hydroxystaurosporine (UCN-01) induces apoptosis in human colon carcinoma and leukemia cells independently of p53.
Topics: Adenocarcinoma; Alkaloids; Apoptosis; Caspase 3; Caspases; CDC2 Protein Kinase; Colonic Neoplasms; Cyclin B; Cyclin B1; Cyclins; Cycloheximide; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; DNA Fragmentation; Enzyme Inhibitors; HL-60 Cells; HT29 Cells; Humans; Lamin Type B; Lamins; Leukemia, Myeloid, Acute; Nuclear Proteins; Poly(ADP-ribose) Polymerases; Protein Kinase C; Protein Synthesis Inhibitors; Serine Proteinase Inhibitors; Staurosporine; Tumor Cells, Cultured; Tumor Suppressor Protein p53 | 1997 |
Induction of caspase-3 protease activity and apoptosis by butyrate and trichostatin A (inhibitors of histone deacetylase): dependence on protein synthesis and synergy with a mitochondrial/cytochrome c-dependent pathway.
Topics: Apoptosis; bcl-2-Associated X Protein; Butyrates; Butyric Acid; Caspase 3; Caspases; Cells, Cultured; Cycloheximide; Cysteine Endopeptidases; Cytochrome c Group; DNA Fragmentation; DNA, Neoplasm; Enzyme Induction; Histone Deacetylases; Humans; Hydroxamic Acids; Jurkat Cells; Protein Biosynthesis; Protein Kinase Inhibitors; Protein Synthesis Inhibitors; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Staurosporine | 1997 |
Mediation of neuronal apoptosis by enhancement of outward potassium current.
Topics: Amino Acid Chloromethyl Ketones; Animals; Apoptosis; Benzopyrans; Calcium; Cerebral Cortex; Cromakalim; Cycloheximide; Cysteine Proteinase Inhibitors; Gadolinium; Mice; N-Methylaspartate; Neurons; Neuroprotective Agents; Nifedipine; Patch-Clamp Techniques; Potassium; Potassium Channels; Pyrroles; Staurosporine; Tetraethylammonium; Tetraethylammonium Compounds; Veratridine | 1997 |
Colon carcinoma cells use different mechanisms to escape CD95-mediated apoptosis.
Topics: Antigens, Neoplasm; Apoptosis; Brefeldin A; Carcinoma; Cell Transformation, Neoplastic; Colonic Neoplasms; Cycloheximide; Cyclopentanes; Dactinomycin; Enzyme Inhibitors; Fas Ligand Protein; fas Receptor; Humans; Immunologic Capping; Interferon-gamma; Intestinal Mucosa; Membrane Glycoproteins; Nucleic Acid Synthesis Inhibitors; Phorbol Esters; Protein Kinase C; Protein Synthesis Inhibitors; Signal Transduction; Staurosporine; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1998 |
U.V.C.-induction of p53 activation and accumulation is dependent on cell cycle and pathways involving protein synthesis and phosphorylation.
Topics: 3T3 Cells; Animals; Antibodies; Cycloheximide; DNA; DNA Replication; Enzyme Inhibitors; G1 Phase; Gene Expression Regulation; Genes, p53; Mice; Protein Synthesis Inhibitors; Resting Phase, Cell Cycle; S Phase; Staurosporine; Time Factors; Tumor Suppressor Protein p53 | 1998 |
Upregulation of cAMP-specific PDE-4 activity following ligation of the TCR complex on thymocytes is blocked by selective inhibitors of protein kinase C and tyrosyl kinases.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Adenylyl Cyclases; Alkaloids; Animals; Benzophenanthridines; CD3 Complex; Cells, Cultured; Cyclic AMP; Cyclic Nucleotide Phosphodiesterases, Type 4; Cycloheximide; Dactinomycin; Enzyme Activation; Enzyme Inhibitors; Mice; Mice, Inbred BALB C; Nucleic Acid Synthesis Inhibitors; Phenanthridines; Protein Kinase C; Protein Synthesis Inhibitors; Protein-Tyrosine Kinases; Receptors, Antigen, T-Cell; Signal Transduction; Staurosporine; Tetradecanoylphorbol Acetate; Thymus Gland; Up-Regulation | 1998 |
Cytomegalovirus activates interferon immediate-early response gene expression and an interferon regulatory factor 3-containing interferon-stimulated response element-binding complex.
Topics: 2-Aminopurine; Apoptosis Regulatory Proteins; Cell Line; Cycloheximide; Cytomegalovirus; DNA-Binding Proteins; eIF-2 Kinase; Enzyme Inhibitors; Gene Expression Regulation, Viral; Genistein; Humans; Interferon Regulatory Factor-1; Interferon Regulatory Factor-2; Interferon Regulatory Factor-3; Interferon-alpha; Interferon-beta; Phosphoproteins; Protein Kinase C; Protein Synthesis Inhibitors; Protein-Tyrosine Kinases; Regulatory Sequences, Nucleic Acid; Repressor Proteins; RNA-Binding Proteins; STAT1 Transcription Factor; STAT2 Transcription Factor; Staurosporine; Trans-Activators; Transcription Factors; Transcriptional Activation | 1998 |
Reversible protein phosphorylation regulates jasmonic acid-dependent and -independent wound signal transduction pathways in Arabidopsis thaliana.
Topics: Arabidopsis; Cycloheximide; Cyclopentanes; Enzyme Inhibitors; Feedback; Gene Expression Regulation, Plant; Genes, Plant; Indoleacetic Acids; Models, Biological; Okadaic Acid; Oxylipins; Phosphoprotein Phosphatases; Phosphorylation; Plant Growth Regulators; Plant Proteins; Protein Kinase Inhibitors; Protein Kinases; Signal Transduction; Staurosporine; Transcriptional Activation | 1998 |
Mechanisms involved in the stimulatory effect of amniotic fluid on prostaglandin production by human fetal membranes.
Topics: Amniotic Fluid; Cells, Cultured; Cesarean Section; Chorion; Cycloheximide; Dactinomycin; Dinoprost; Dinoprostone; Enzyme Inhibitors; Extraembryonic Membranes; Female; Genistein; Humans; Labor, Obstetric; Pregnancy; Prostaglandins; Staurosporine | 1998 |
Are caspases involved in the death of cells with a transcriptionally inactive nucleus? Sperm and chicken erythrocytes.
Topics: Animals; Apoptosis; Caspase Inhibitors; Caspases; Cell Differentiation; Cell Nucleus; Chick Embryo; Chickens; Cycloheximide; Enzyme Activation; Enzyme Inhibitors; Erythrocytes; In Vitro Techniques; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Rats; Rats, Sprague-Dawley; Spermatozoa; Staurosporine; Transcription, Genetic | 1998 |
Regulation of glucose transport by angiotensin II and glucose in cultured vascular smooth muscle cells.
Topics: Amino Acid Sequence; Angiotensin II; Animals; Biological Transport; Calcium Chloride; Calmodulin; Cells, Cultured; Cycloheximide; Deoxyglucose; Enzyme Inhibitors; Glucose; Glucose Transporter Type 1; Imidazoles; Indoles; Male; Maleimides; Molecular Sequence Data; Monosaccharide Transport Proteins; Muscle, Smooth, Vascular; Protein Kinase C; Protein Synthesis Inhibitors; Rats; Rats, Sprague-Dawley; Staurosporine; Sulfonamides; Vasodilator Agents | 1998 |
Keratinocyte growth factor promotes alveolar epithelial cell DNA repair after H2O2 exposure.
Topics: Animals; Aphidicolin; Cell Death; Cycloheximide; Dactinomycin; DNA Damage; DNA Repair; Enzyme Inhibitors; Fibroblast Growth Factor 10; Fibroblast Growth Factor 7; Fibroblast Growth Factors; Genistein; Growth Substances; Humans; Hydrogen Peroxide; Kinetics; Lung Neoplasms; Naphthalenes; Protein Kinase C; Protein-Tyrosine Kinases; Pulmonary Alveoli; Rats; Staurosporine; Tumor Cells, Cultured | 1998 |
Prostaglandin E2 increases proenkephalin mRNA level in rat astrocyte-enriched culture.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Animals, Newborn; Astrocytes; Cells, Cultured; Cerebral Cortex; Cyclic AMP Response Element-Binding Protein; Cycloheximide; Dinoprostone; Enkephalins; Enzyme Inhibitors; Flavonoids; Imidazoles; Isoquinolines; Kinetics; Nimodipine; omega-Conotoxin GVIA; Peptides; Phosphorylation; Protein Precursors; Proto-Oncogene Proteins c-jun; Rats; Rats, Sprague-Dawley; RNA, Messenger; Staurosporine; Sulfonamides; Transcription Factor AP-1; Transcription, Genetic | 1998 |
Cleavage of DFF-45/ICAD by multiple caspases is essential for its function during apoptosis.
Topics: Apoptosis; Apoptosis Regulatory Proteins; Caspase 3; Caspases; Cycloheximide; Gelsolin; Humans; Hydrolysis; Proteins; Staurosporine; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha | 1998 |
Phosphorylation and activation of p70 S6 kinase by manganese in PC12 cells.
Topics: Animals; Anisomycin; Antibodies; Antibody Specificity; Apoptosis; Binding Sites; Calcium-Calmodulin-Dependent Protein Kinases; Camptothecin; Cisplatin; Cycloheximide; DNA Fragmentation; Enzyme Activation; Immunoblotting; JNK Mitogen-Activated Protein Kinases; Manganese; Mitogen-Activated Protein Kinases; PC12 Cells; Phosphorylation; Protein Processing, Post-Translational; Proto-Oncogene Proteins c-bcl-2; Rats; Ribosomal Protein S6 Kinases; Serine; Staurosporine; Threonine | 1998 |
Effect of serum starvation on expression and phosphorylation of PKC-alpha and p53 in V79 cells: implications for cell death.
Topics: Animals; Apoptosis; Cells, Cultured; Cricetinae; Cricetulus; Culture Media, Serum-Free; Cycloheximide; Dactinomycin; Enzyme Inhibitors; Fibroblasts; Isoenzymes; Phosphorylation; Protein Kinase C; Protein Kinase C-alpha; Staurosporine; Tetradecanoylphorbol Acetate; Tumor Suppressor Protein p53 | 1999 |
Down-regulation of liver JAK2-STAT5b signaling by the female plasma pattern of continuous growth hormone stimulation.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Cells, Cultured; Cycloheximide; Cysteine Proteinase Inhibitors; DNA-Binding Proteins; Down-Regulation; Electrophoresis; Female; Genistein; Growth Hormone; Growth Inhibitors; Janus Kinase 2; Leupeptins; Liver; Male; Milk Proteins; Protein Synthesis Inhibitors; Protein Tyrosine Phosphatases; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Rats; Signal Transduction; STAT5 Transcription Factor; Staurosporine; Trans-Activators; Vanadates | 1999 |
Estrogens induce apoptosis in mouse peritoneal macrophages.
Topics: Animals; Apoptosis; Cycloheximide; DNA Fragmentation; Estradiol; Estrogen Antagonists; Estrone; Female; Macrophages, Peritoneal; Mice; Protein Kinase C; Protein Synthesis Inhibitors; Staurosporine; Tamoxifen | 1997 |
Regulation of complement factor H in a human liver cell line by interferon-gamma.
Topics: Complement Factor H; Cycloheximide; Dose-Response Relationship, Drug; Enzyme Inhibitors; Gene Expression Regulation; Humans; Interferon-gamma; Kinetics; Liver; Protein Biosynthesis; Protein Kinase Inhibitors; Protein Synthesis Inhibitors; RNA, Messenger; Staurosporine; Time Factors; Tumor Cells, Cultured | 1999 |
Sequential cleavage of poly(ADP-ribose)polymerase and appearance of a small Bax-immunoreactive protein are blocked by Bcl-X(L) and caspase inhibitors during staurosporine-induced dopaminergic neuronal apoptosis.
Topics: Animals; Apoptosis; bcl-2-Associated X Protein; bcl-X Protein; Caspase Inhibitors; Cell Line; Cycloheximide; Dopamine; Kinetics; Mice; Neurons; Poly(ADP-ribose) Polymerases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Recombinant Proteins; Staurosporine; Transfection | 1999 |
Involvement of p38 MAPK and ERK/MAPK pathways in staurosporine-induced production of macrophage inflammatory protein-2 in rat peritoneal neutrophils.
Topics: Animals; Calcium-Calmodulin-Dependent Protein Kinases; Chemokine CXCL2; Cycloheximide; Down-Regulation; Enzyme Inhibitors; Flavonoids; Male; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Monokines; Neutrophils; p38 Mitogen-Activated Protein Kinases; Peritoneum; Rats; Rats, Sprague-Dawley; RNA, Messenger; Staurosporine | 1999 |
Mechanical stretch induces platelet-activating factor receptor gene expression through the NF-kappaB transcription factor.
Topics: Animals; Base Sequence; Cattle; Cells, Cultured; Cycloheximide; Enzyme Inhibitors; Gene Expression Regulation; Molecular Sequence Data; Muscle, Smooth, Vascular; Naphthalenes; NF-kappa B; NF-kappa B p50 Subunit; Nucleic Acid Synthesis Inhibitors; Physical Stimulation; Platelet Membrane Glycoproteins; Protein Kinase C; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Staurosporine | 1999 |
Characterization of MPP(+)-induced cell death in a dopaminergic neuronal cell line: role of macromolecule synthesis, cytosolic calcium, caspase, and Bcl-2-related proteins.
Topics: 1-Methyl-4-phenylpyridinium; Amino Acid Chloromethyl Ketones; Animals; bcl-2-Associated X Protein; Calcium; Caspases; Cell Death; Cell Line; Cycloheximide; Cysteine Proteinase Inhibitors; Cytosol; Dactinomycin; Dopamine; Dopamine Agents; Emetine; Enzyme Inhibitors; Humans; In Situ Nick-End Labeling; Mesencephalon; Mice; Microscopy, Electron; Nerve Tissue Proteins; Neurons; Neuroprotective Agents; Protein Synthesis Inhibitors; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Staurosporine | 1999 |
Inhibition of "tissue" transglutaminase increases cell survival by preventing apoptosis.
Topics: Apoptosis; Calcimycin; Cell Death; Cell Survival; Cycloheximide; Dactinomycin; DNA, Antisense; Gene Expression Regulation, Enzymologic; Humans; Naphthalenes; RNA, Antisense; Staurosporine; Transcription, Genetic; Transfection; Transglutaminases; Tretinoin; Tumor Cells, Cultured | 1999 |
Prevention of neuronal apoptosis by phorbol ester-induced activation of protein kinase C: blockade of p38 mitogen-activated protein kinase.
Topics: Amyloid beta-Peptides; Animals; Brain-Derived Neurotrophic Factor; Cell Hypoxia; Cells, Cultured; Cerebral Cortex; Coculture Techniques; Culture Media, Serum-Free; Cycloheximide; Enzyme Inhibitors; Flavonoids; Imidazoles; Indoles; JNK Mitogen-Activated Protein Kinases; Kinetics; Maleimides; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinases; Neurons; p38 Mitogen-Activated Protein Kinases; Peptide Fragments; Phorbol Esters; Protein Kinase C; Pyridines; Staurosporine; Tetradecanoylphorbol Acetate | 1999 |
Regulated trafficking of the human dopamine transporter. Clathrin-mediated internalization and lysosomal degradation in response to phorbol esters.
Topics: Acetylcysteine; Animals; Carrier Proteins; Cell Line; Chloroquine; Clathrin; Colforsin; Cycloheximide; Dogs; Dopamine; Dopamine Plasma Membrane Transport Proteins; Endocytosis; Enzyme Activation; Humans; Kinetics; Lysosomes; Membrane Glycoproteins; Membrane Transport Proteins; Nerve Tissue Proteins; Phorbols; Protein Kinase C; Recombinant Proteins; Staurosporine; Tetradecanoylphorbol Acetate; Transfection | 1999 |
Syringolin-mediated activation of the Pir7b esterase gene in rice cells is suppressed by phosphatase inhibitors.
Topics: Carbazoles; Cycloheximide; Enzyme Inhibitors; Esterases; Indole Alkaloids; Okadaic Acid; Oryza; Phosphoprotein Phosphatases; Phosphorylation; Plant Proteins; Protein Synthesis Inhibitors; RNA, Messenger; Signal Transduction; Staurosporine; Transcription, Genetic | 2000 |
Despite the internucleosomal cleavage of DNA, reactive oxygen species do not produce other markers of apoptosis in cultured neurons.
Topics: Animals; Antioxidants; Apoptosis; Biomarkers; Caspases; Cell Nucleus; Cholinesterase Inhibitors; Comet Assay; Cycloheximide; DNA Fragmentation; Enzyme Inhibitors; Female; Free Radical Scavengers; Glutamic Acid; Metalloporphyrins; Molsidomine; Nerve Degeneration; Nerve Tissue Proteins; Neurons; Nucleosomes; Oxidation-Reduction; Phenanthrolines; Pregnancy; Protein Synthesis Inhibitors; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Staurosporine; Uric Acid | 2000 |
Cleavage of BID during cytotoxic drug and UV radiation-induced apoptosis occurs downstream of the point of Bcl-2 action and is catalysed by caspase-3: a potential feedback loop for amplification of apoptosis-associated mitochondrial cytochrome c release.
Topics: Animals; Apoptosis; Aspartic Acid; BH3 Interacting Domain Death Agonist Protein; Carrier Proteins; Caspase 3; Caspases; Catalysis; Cell-Free System; Cycloheximide; Cytochrome c Group; Enzyme Inhibitors; Etoposide; Humans; Jurkat Cells; Mice; Mitochondria, Liver; Nucleic Acid Synthesis Inhibitors; Protein Synthesis Inhibitors; Proto-Oncogene Proteins c-bcl-2; Staurosporine; Tumor Cells, Cultured; Ultraviolet Rays | 2000 |
Normotonic cell shrinkage because of disordered volume regulation is an early prerequisite to apoptosis.
Topics: Animals; Apoptosis; Caspase 3; Caspase Inhibitors; Caspases; Cell Size; Cell Survival; Chlorides; Cycloheximide; Cytochrome c Group; DNA Fragmentation; Enzyme Activation; Humans; Ion Channels; Microscopy, Electron; Mitochondria; Potassium; Staurosporine; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha | 2000 |
A novel rice (Oryza sativa L.) acidic PR1 gene highly responsive to cut, phytohormones, and protein phosphatase inhibitors.
Topics: Abscisic Acid; Amino Acid Sequence; Base Sequence; Cantharidin; Cloning, Molecular; Cycloheximide; Dicarboxylic Acids; DNA, Complementary; Dose-Response Relationship, Drug; Down-Regulation; Enzyme Inhibitors; Ethylenes; Gene Expression Regulation, Plant; Gene Library; Gibberellins; Hydrogen-Ion Concentration; Indoleacetic Acids; Keratolytic Agents; Light; Molecular Sequence Data; Multigene Family; Oryza; Phosphorylation; Plant Growth Regulators; Plant Proteins; Protein Synthesis Inhibitors; RNA, Messenger; Salicylic Acid; Sequence Analysis, DNA; Sequence Homology, Amino Acid; Staurosporine; Time Factors; Transcription, Genetic | 2000 |
Screening of wound-responsive genes identifies an immediate-early expressed gene encoding a highly charged protein in mechanically wounded tobacco plants.
Topics: Amino Acid Sequence; Cycloheximide; Cytosol; DNA, Complementary; Egtazic Acid; Erythrosine; Gene Expression Regulation, Plant; Genes, Immediate-Early; Immediate-Early Proteins; Kinetics; Molecular Sequence Data; Molecular Weight; Nicotiana; Okadaic Acid; Plant Proteins; Plants, Toxic; Propionates; Sequence Homology, Amino Acid; Staurosporine; Time Factors; Transcription, Genetic | 2000 |
Limited caspase cleavage of human BAP31.
Topics: Amino Acid Sequence; Animals; Antibodies, Monoclonal; Apoptosis; Binding Sites; Caspases; Cycloheximide; Endoplasmic Reticulum; fas Receptor; Golgi Apparatus; HeLa Cells; Humans; Mannosidases; Membrane Proteins; Mice; Mice, Inbred BALB C; Protein Transport; Proteins; Recombinant Fusion Proteins; Staurosporine; Transfection; Tumor Necrosis Factor-alpha; Tunicamycin | 2000 |
Expression of interleukin-4 in apoptotic cells: stimulation of the type-2 cytokine by different toxins in human peripheral blood mononuclear and tumor cells.
Topics: Apoptosis; Brefeldin A; Caspase Inhibitors; Caspases; CD4-Positive T-Lymphocytes; CD8-Positive T-Lymphocytes; Cells, Cultured; Cycloheximide; Dactinomycin; DNA Fragmentation; Enzyme Inhibitors; Flow Cytometry; Humans; In Situ Nick-End Labeling; Interferon-gamma; Interleukin-4; Mitochondria; Oxidative Phosphorylation; Plant Preparations; Plant Proteins; Proto-Oncogene Proteins c-bcl-2; Ribosome Inactivating Proteins, Type 2; Staurosporine; T-Lymphocytes; Toxins, Biological; Tumor Cells, Cultured | 2000 |
Natural protection from apoptosis by surfactant protein A in type II pneumocytes.
Topics: Animals; Apoptosis; Carrier Proteins; Cell Separation; Cells, Cultured; Cycloheximide; Dexamethasone; Enzyme Inhibitors; Etoposide; Female; Flow Cytometry; Glucocorticoids; Glycoproteins; Humans; In Situ Nick-End Labeling; Nucleic Acid Synthesis Inhibitors; Phosphatidylinositol 3-Kinases; Protein Synthesis Inhibitors; Proteolipids; Pulmonary Alveoli; Pulmonary Surfactant-Associated Protein A; Pulmonary Surfactant-Associated Proteins; Pulmonary Surfactants; Rats; Signal Transduction; Staurosporine; Ultraviolet Rays | 2001 |
NF-kappaB activation and susceptibility to apoptosis after polyamine depletion in intestinal epithelial cells.
Topics: Animals; Apoptosis; Cell Line; Cycloheximide; DNA Fragmentation; Eflornithine; G1 Phase; Intestinal Mucosa; Kinetics; NF-kappa B; Nucleosomes; Polyamines; Putrescine; Rats; Spermidine; Spermine; Staurosporine; Time Factors; Tumor Necrosis Factor-alpha | 2001 |
Caspase cleavage of vimentin disrupts intermediate filaments and promotes apoptosis.
Topics: Apoptosis; Aspartic Acid; Carrier Proteins; Caspase 3; Caspase 6; Caspase 7; Caspase Inhibitors; Caspases; Cell Line; Cloning, Molecular; Cycloheximide; Electrophoresis, Polyacrylamide Gel; HeLa Cells; Humans; Intermediate Filaments; Microfilament Proteins; Mutation; Protein Processing, Post-Translational; Staurosporine; Transfection; Tumor Necrosis Factor-alpha; Vimentin | 2001 |
Ca2+-dependent and Ca2+-independent excretion modes of salicylic acid in tobacco cell suspension culture.
Topics: Autoradiography; Calcium; Cell Line; Cells, Cultured; Chromatography, Thin Layer; Cycloheximide; Egtazic Acid; Enzyme Inhibitors; Glutathione; Isotope Labeling; Nicotiana; Plant Proteins; Plants, Toxic; Salicylic Acid; Staurosporine | 2001 |
PKCdelta-dependent deubiquitination and stabilization of Gadd45 in A431 cells overexposed to EGF.
Topics: Acetophenones; Benzopyrans; Cell Division; Cycloheximide; DNA Damage; Enzyme Activation; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; Flavonoids; GADD45 Proteins; Humans; Imidazoles; Intracellular Signaling Peptides and Proteins; Isoenzymes; Kinetics; Leupeptins; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Protein Kinase C; Protein Kinase C-delta; Proteins; Pyridines; Recombinant Proteins; Staurosporine; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Ubiquitins | 2001 |
Preconditioning-induced neuroprotection is mediated by reactive oxygen species and activation of the transcription factor nuclear factor-kappaB.
Topics: Acetylcysteine; Animals; Antioxidants; Apoptosis; Astrocytes; Cells, Cultured; Cycloheximide; Enzyme Inhibitors; Ferrous Compounds; Hippocampus; Immunoblotting; Immunohistochemistry; Neurons; NF-kappa B; Protein Synthesis Inhibitors; Rats; Rats, Inbred F344; Reactive Oxygen Species; Staurosporine; Superoxide Dismutase; Xanthine; Xanthine Oxidase | 2001 |
Multiple kinetics of mitochondrial cytochrome c release in drug-induced apoptosis.
Topics: Apoptosis; Caspase Inhibitors; Caspases; Cycloheximide; Cytochrome c Group; Digitonin; Drug Interactions; Enzyme Activation; Enzyme Inhibitors; Green Fluorescent Proteins; Humans; Indicators and Reagents; Kinetics; Luminescent Proteins; Mitochondria; Protein Synthesis Inhibitors; Staurosporine; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha; Valinomycin | 2001 |
Characterization of the increase in bone 66 kDa protein component with healing rat fractures: stimulatory effect of zinc.
Topics: Animals; Bone and Bones; Cycloheximide; Dactinomycin; Electrophoresis, Polyacrylamide Gel; Estradiol; Flavonoids; Fracture Healing; Fractures, Bone; Insulin-Like Growth Factor I; Male; Parathyroid Hormone; Phosphoproteins; Rats; Rats, Wistar; Staurosporine; Time Factors; Transforming Growth Factor beta; Zinc | 2002 |
Staurosporine induces endothelial cell apoptosis via focal adhesion kinase dephosphorylation and focal adhesion disassembly independent of focal adhesion kinase proteolysis.
Topics: Animals; Annexin A5; Aorta; Apoptosis; Blotting, Western; Cell Survival; Cells, Cultured; Cycloheximide; Endothelium, Vascular; Enzyme Inhibitors; Focal Adhesion Protein-Tyrosine Kinases; Focal Adhesions; In Situ Nick-End Labeling; Microscopy, Fluorescence; Phosphatidylinositol 3-Kinases; Phosphorylation; Precipitin Tests; Protein Binding; Protein Kinase C; Protein Synthesis Inhibitors; Protein-Tyrosine Kinases; Staurosporine; Swine; Time Factors; Tyrosine | 2002 |
Regulation of matrix metalloproteinase production by cytokines, pharmacological agents and periodontal pathogens in human periodontal ligament fibroblast cultures.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Aggregatibacter actinomycetemcomitans; Cells, Cultured; Cycloheximide; Electrophoresis, Polyacrylamide Gel; Enzyme Inhibitors; Fibroblasts; Gene Expression Regulation, Enzymologic; Humans; Interleukin-1; Matrix Metalloproteinase 2; Periodontal Diseases; Periodontal Ligament; Porphyromonas gingivalis; Protein Kinase C; Protein Synthesis Inhibitors; Staurosporine; Tissue Inhibitor of Metalloproteinase-2; Transforming Growth Factor beta | 2002 |
Hyperosmotic stimuli inhibit VCAM-1 expression in cultured endothelial cells via effects on interferon regulatory factor-1 expression and activity.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Cell Membrane; Cells, Cultured; Culture Media; Cycloheximide; DNA-Binding Proteins; E-Selectin; Endothelium, Vascular; Gene Expression Regulation; GTP-Binding Proteins; Imidazoles; Intercellular Adhesion Molecule-1; Interferon Regulatory Factor-1; Interferon-gamma; Interferon-Stimulated Gene Factor 3; Interleukin-1; Interleukin-13; Interleukin-4; NF-kappa B; Okadaic Acid; Osmosis; Phosphoproteins; Promoter Regions, Genetic; Pyridines; RNA, Messenger; Staurosporine; Transcription Factors; Transcription, Genetic; Transcriptional Activation; Tumor Necrosis Factor-alpha; Vascular Cell Adhesion Molecule-1 | 2002 |
Regulation of intracellular pH mediates Bax activation in HeLa cells treated with staurosporine or tumor necrosis factor-alpha.
Topics: Apoptosis; bcl-2-Associated X Protein; BH3 Interacting Domain Death Agonist Protein; Blotting, Western; Calibration; Carrier Proteins; Caspase 8; Caspase 9; Caspase Inhibitors; Cell Survival; Chloride Channels; Cycloheximide; Cytochrome c Group; Cytosol; Diuretics; Enzyme Inhibitors; Furosemide; HeLa Cells; Humans; Hydrogen-Ion Concentration; Mitochondria; Oligopeptides; Protein Binding; Protein Synthesis Inhibitors; Protein Transport; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Staurosporine; Time Factors; Tumor Necrosis Factor-alpha | 2002 |
Cell shape change precedes staurosporine-induced stabilization and accumulation of p27kip1.
Topics: Cell Cycle; Cell Cycle Proteins; Cell Size; Cyclin-Dependent Kinase Inhibitor p27; Cyclin-Dependent Kinases; Cycloheximide; Cysteine Endopeptidases; Cytochalasin D; Cytoskeleton; Diacetyl; Enzyme Inhibitors; Female; Flow Cytometry; Humans; Lung Neoplasms; Microscopy, Confocal; Multienzyme Complexes; Nucleic Acid Synthesis Inhibitors; Proteasome Endopeptidase Complex; Protein Synthesis Inhibitors; Staurosporine; Tumor Cells, Cultured; Tumor Suppressor Proteins; Uterine Cervical Neoplasms | 2002 |
Neurites undergoing Wallerian degeneration show an apoptotic-like process with Annexin V positive staining and loss of mitochondrial membrane potential.
Topics: Animals; Annexin A5; Apoptosis; Axotomy; Cell Culture Techniques; Cycloheximide; Enzyme Inhibitors; Ganglia, Spinal; Immunohistochemistry; Membrane Potentials; Mice; Mitochondria; Neurites; Osmolar Concentration; Protein Synthesis Inhibitors; Staurosporine; Wallerian Degeneration | 2003 |
Soluble extracts from Helicobacter pylori induce dome formation in polarized intestinal epithelial monolayers in a laminin-dependent manner.
Topics: Animals; Apoptosis; Benzoquinones; Cell Line; Cell Polarity; Chlorides; Cycloheximide; Cytoskeleton; Helicobacter pylori; Humans; Integrin alpha6; Integrin beta4; Intestinal Mucosa; Lactams, Macrocyclic; Laminin; Microscopy, Electron; Quinones; Rifabutin; Staurosporine | 2003 |
Staurosporine induces rapid homotypic intercellular adhesion of U937 cells via multiple kinase activation.
Topics: Acetophenones; Adenosine Triphosphate; Benzopyrans; Calcium-Calmodulin-Dependent Protein Kinases; Carbazoles; CD18 Antigens; Cell Aggregation; Cycloheximide; Cytoskeleton; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Genistein; Humans; Imidazoles; Indoles; Integrin beta1; Isoenzymes; Maleimides; Mitogen-Activated Protein Kinases; Naphthalenes; Phosphorylation; Phosphotransferases; Protein Kinase C; Protein-Tyrosine Kinases; Pyridines; Staurosporine; Temperature; Tetradecanoylphorbol Acetate; Time Factors; Tyrosine; U937 Cells | 2003 |
A rice isoflavone reductase-like gene, OsIRL, is induced by rice blast fungal elicitor.
Topics: Abscisic Acid; Amino Acid Sequence; Base Sequence; Cloning, Molecular; Cycloheximide; Cyclopentanes; DNA, Complementary; Gene Expression Regulation, Plant; Genes, Plant; Madurella; Molecular Sequence Data; Oryza; Oxylipins; Plant Growth Regulators; Sequence Homology, Amino Acid; Staurosporine; Zea mays | 2003 |
Sensitive genetic biomarkers for determining apoptosis in the brown bullhead (Ameiurus nebulosus).
Topics: Animals; Apoptosis; Biomarkers, Tumor; Cell Line; Cycloheximide; Fibroblasts; Fish Proteins; Gene Expression; Genetic Markers; Ictaluridae; In Situ Nick-End Labeling; Molecular Sequence Data; Proto-Oncogene Proteins c-fos; Sensitivity and Specificity; Staurosporine; Time Factors; Tumor Necrosis Factor-alpha; Tumor Suppressor Protein p53 | 2004 |
Arabidopsis RAV1 is down-regulated by brassinosteroid and may act as a negative regulator during plant development.
Topics: 2,4-Dichlorophenoxyacetic Acid; Arabidopsis; Arabidopsis Proteins; Blotting, Northern; Blotting, Southern; Blotting, Western; Brassinosteroids; Cholestanols; Cycloheximide; DNA-Binding Proteins; DNA, Antisense; Down-Regulation; Flowers; Gene Dosage; Gene Expression Regulation, Developmental; Gene Expression Regulation, Plant; Models, Biological; Mutation; Okadaic Acid; Oligonucleotide Array Sequence Analysis; Plant Growth Regulators; Plant Leaves; Plant Roots; Plants, Genetically Modified; Protein Kinases; Rhizobium; Signal Transduction; Staurosporine; Steroids, Heterocyclic; Transformation, Genetic; Zeatin | 2004 |
Characterization of 4-O-methyl-ascochlorin-induced apoptosis in comparison with typical apoptotic inducers in human leukemia cell lines.
Topics: Adaptor Proteins, Signal Transducing; Apoptosis; Blotting, Western; Caspase 3; Caspase 8; Caspase 9; Caspase Inhibitors; Caspases; Cycloheximide; Cytochromes c; Dactinomycin; DNA Fragmentation; fas Receptor; Fas-Associated Death Domain Protein; Humans; Immunoglobulin M; Jurkat Cells; Oligopeptides; Poly(ADP-ribose) Polymerases; Proto-Oncogene Proteins c-bcl-2; Staurosporine; Terpenes | 2004 |
Activation of apoptosis and caspase-3 in zebrafish early gastrulae.
Topics: Adenosine Diphosphate Ribose; Animals; Apoptosis; Caspase 3; Caspases; Cell Adhesion; Cell Nucleus; Cycloheximide; Embryo, Nonmammalian; Gastrula; Phosphatidylserines; Staurosporine; Zebrafish | 2004 |
Reversible connexin 43 dephosphorylation during hypoxia and reoxygenation is linked to cellular ATP levels.
Topics: Adenosine Triphosphate; Alkaloids; Aminoimidazole Carboxamide; Animals; Antimycin A; Benzophenanthridines; Brefeldin A; Carbazoles; Cell Hypoxia; Cells, Cultured; Connexin 43; Cycloheximide; Deoxyglucose; Flavonoids; Imidazoles; Indoles; JNK Mitogen-Activated Protein Kinases; Maleimides; Myocardial Contraction; Myocytes, Cardiac; Okadaic Acid; Ouabain; Phenanthridines; Phosphorylation; Potassium Cyanide; Protein Processing, Post-Translational; Pyridines; Pyrroles; Rats; Recombinant Fusion Proteins; Ribonucleotides; Staurosporine; Tacrolimus; Tetradecanoylphorbol Acetate | 2004 |
Amyloid beta(1-42) and its beta(25-35) fragment induce activation and membrane translocation of cytosolic phospholipase A2 in bovine retina capillary pericytes.
Topics: Amyloid beta-Peptides; Animals; Arachidonic Acid; Arachidonic Acids; bcl-2-Associated X Protein; Caspase Inhibitors; Caspases; Cattle; Cells, Cultured; Cycloheximide; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Gene Expression; Group VI Phospholipases A2; Naphthalenes; Oligopeptides; Peptide Fragments; Pericytes; Phospholipases A; Phospholipases A2; Phosphorylation; Poly(ADP-ribose) Polymerases; Protein Transport; Proto-Oncogene Proteins c-bcl-2; Pyrones; Retinal Artery; Staurosporine; Subcellular Fractions | 2004 |
NF-kappa B activation is not required for Chlamydia trachomatis inhibition of host epithelial cell apoptosis.
Topics: Apoptosis; Chlamydia trachomatis; Cycloheximide; Diterpenes; Epithelial Cells; Gene Deletion; HeLa Cells; Humans; Immunity, Innate; NF-kappa B; Sesquiterpenes; Signal Transduction; Staurosporine; Transcription Factor RelA | 2005 |
Early apoptotic and late necrotic components associated with altered Ca2+ homeostasis in a peptide-delivery model of polyglutamine-induced neuronal death.
Topics: Amino Acid Chloromethyl Ketones; Animals; Animals, Newborn; Apoptosis; Blotting, Western; Calcium; Carbonyl Cyanide m-Chlorophenyl Hydrazone; Caspase 3; Caspase 7; Caspases; Cell Count; Cells, Cultured; Colforsin; Cyclin D1; Cycloheximide; Dihydrotachysterol; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Inhibitors; Homeostasis; Immunohistochemistry; In Situ Nick-End Labeling; Ionophores; Lactic Acid; Mitochondria; Models, Biological; Necrosis; Nerve Growth Factor; Neurons; Neuroprotective Agents; Peptides; Permeability; Protein Synthesis Inhibitors; Proto-Oncogene Proteins c-jun; Rats; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Staurosporine; Superior Cervical Ganglion; Time Factors | 2005 |
Apoptosis of ejaculated human sperm is induced by co-incubation with Chlamydia trachomatis lipopolysaccharide.
Topics: Amino Acid Chloromethyl Ketones; Apoptosis; Caspase Inhibitors; Caspases; Chlamydia trachomatis; Cycloheximide; Cysteine Proteinase Inhibitors; Dactinomycin; Ejaculation; Enzyme Inhibitors; Humans; In Vitro Techniques; Lipopolysaccharides; Male; Protein Synthesis Inhibitors; Spermatozoa; Staurosporine; Substrate Specificity | 2005 |
Enhanced JNK activation by NESK without kinase activity upon caspase-mediated cleavage during apoptosis.
Topics: Apoptosis; Caspases; Cell Line; Cycloheximide; Enzyme Activation; Enzyme Inhibitors; Humans; Intracellular Signaling Peptides and Proteins; MAP Kinase Kinase 4; Mutation; Phosphorylation; Protein Binding; Protein Serine-Threonine Kinases; Protein Structure, Tertiary; Signal Transduction; Staurosporine; Tumor Necrosis Factor-alpha | 2005 |
Inhibition of PACAP activity by a receptor antagonist results in changes in cell cycle and apoptotic proteins in chick neuroblasts.
Topics: Animals; Apoptosis; Cell Cycle; Cell Differentiation; Cells, Cultured; Chick Embryo; Cycloheximide; Enzyme Inhibitors; Isotope Labeling; Mitochondrial Proteins; Nerve Growth Factors; Neurons; Neuropeptides; Neurotransmitter Agents; Pituitary Adenylate Cyclase-Activating Polypeptide; Protein Synthesis Inhibitors; Receptors, Cell Surface; Receptors, Pituitary Adenylate Cyclase-Activating Polypeptide; Staurosporine; Tumor Suppressor Proteins | 2005 |
Cycloheximide-mediated sensitization to TNF-alpha-induced apoptosis in human colorectal cancer cell line COLO 205; role of FLIP and metabolic inhibitors.
Topics: Apoptosis; Calcimycin; Calcium; CASP8 and FADD-Like Apoptosis Regulating Protein; Cell Line, Tumor; Cell Survival; Chelating Agents; Colorectal Neoplasms; Cycloheximide; Dactinomycin; Drug Synergism; Edetic Acid; Egtazic Acid; Enzyme Activation; Enzyme Activators; Humans; Ionophores; Protein Kinase C; Protein Kinase Inhibitors; Protein Synthesis Inhibitors; Signal Transduction; Staurosporine; Tetradecanoylphorbol Acetate; Time Factors; Tumor Escape; Tumor Necrosis Factor-alpha | 2005 |
Constitutive proteasome-mediated turnover of Bfl-1/A1 and its processing in response to TNF receptor activation in FL5.12 pro-B cells convert it into a prodeath factor.
Topics: Amino Acid Sequence; Animals; Apoptosis; B-Lymphocytes; Calpain; Cell Death; Cell Line; Cycloheximide; Flow Cytometry; Green Fluorescent Proteins; Humans; Immunoprecipitation; Lysine; Mice; Minor Histocompatibility Antigens; Models, Biological; Molecular Sequence Data; Mutagenesis; Mutation; Phenotype; Plasmids; Proteasome Endopeptidase Complex; Protein Binding; Protein Biosynthesis; Protein Structure, Tertiary; Proto-Oncogene Proteins c-bcl-2; Receptors, Tumor Necrosis Factor; Sequence Homology, Amino Acid; Staurosporine; Transfection; Ubiquitin | 2005 |
Upregulation of alpha globin promotes apoptotic cell death in the hematopoietic cell line FL5.12.
Topics: Amino Acid Chloromethyl Ketones; Animals; Apoptosis; B-Lymphocytes; bcl-2-Associated X Protein; BH3 Interacting Domain Death Agonist Protein; Caspases; Cell Line; Cisplatin; Cycloheximide; Cytochromes c; Doxorubicin; Globins; Green Fluorescent Proteins; HeLa Cells; Hematopoietic Stem Cells; Heme; Humans; Interleukin-3; K562 Cells; Mice; NIH 3T3 Cells; Oligonucleotide Array Sequence Analysis; Staurosporine; Tumor Necrosis Factor-alpha; Up-Regulation | 2005 |
The extracellular release of HMGB1 during apoptotic cell death.
Topics: Amino Acid Chloromethyl Ketones; Antineoplastic Agents, Phytogenic; Apoptosis; Camptothecin; Cell Line; Cycloheximide; Cysteine Proteinase Inhibitors; Enzyme Inhibitors; Etoposide; HMGB1 Protein; Humans; Hydroxamic Acids; Protein Synthesis Inhibitors; Staurosporine; Tumor Necrosis Factor-alpha | 2006 |
The C-terminal products of cellular prion protein processing, C1 and C2, exert distinct influence on p53-dependent staurosporine-induced caspase-3 activation.
Topics: Animals; Caspase 3; Cell Survival; Cycloheximide; DNA, Complementary; Enzyme Activation; Humans; L-Lactate Dehydrogenase; Mice; Peptide-N4-(N-acetyl-beta-glucosaminyl) Asparagine Amidase; Prions; Protein Structure, Tertiary; Staurosporine; Transfection; Tumor Suppressor Protein p53 | 2007 |
Changes in gap junction organization and decreased coupling during induced apoptosis in lens epithelial and NIH-3T3 cells.
Topics: Animals; Apoptosis; Caspases; Cattle; Cells, Cultured; Connexin 43; Cycloheximide; Epithelial Cells; Etoposide; Gap Junctions; Lens, Crystalline; Mice; NIH 3T3 Cells; Phosphorylation; Puromycin; Staurosporine | 2007 |
Early-stage apoptosis is associated with DNA-damage-independent ATM phosphorylation and chromatin decondensation in NIH3T3 fibroblasts.
Topics: Animals; Apoptosis; Ataxia Telangiectasia Mutated Proteins; Caspase 3; Cell Cycle Proteins; Chromatin; Cycloheximide; DNA Damage; DNA Fragmentation; DNA-Binding Proteins; Enzyme Activation; Hypotonic Solutions; Mice; NIH 3T3 Cells; Phosphorylation; Protein Serine-Threonine Kinases; Staurosporine; Tumor Necrosis Factor-alpha; Tumor Suppressor Proteins | 2008 |
Bacillus anthracis spores and lethal toxin induce IL-1beta via functionally distinct signaling pathways.
Topics: Animal Structures; Animals; Anthrax; Antigens, Bacterial; Apoptosis; Bacillus anthracis; Bacterial Toxins; Caspase 1; Cycloheximide; Cytochalasin D; Interleukin-1beta; Lipopolysaccharides; Macrophages, Peritoneal; Mice; Mice, Inbred C57BL; Mice, Inbred Strains; Mice, Knockout; Myeloid Differentiation Factor 88; Nitric Oxide; Phagocytosis; Phosphorylation; Signal Transduction; Spores, Bacterial; STAT1 Transcription Factor; Staurosporine; Survival Analysis | 2008 |
Multidrug resistance-associated protein 1 as a major mediator of basal and apoptotic glutathione release.
Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Cell Line; Cycloheximide; Enzyme Inhibitors; Fluoresceins; Glutathione; Humans; Leukotriene C4; Multidrug Resistance-Associated Proteins; Protein Synthesis Inhibitors; Staurosporine; Vincristine | 2008 |
Apoptotic endothelial cells demonstrate increased adhesiveness for human mesenchymal stem cells.
Topics: Androstadienes; Animals; Antigens, Surface; Apoptosis; Cell Adhesion; Cells, Cultured; Cycloheximide; Endothelial Cells; Enzyme Inhibitors; Humans; Interleukin-1beta; Membrane Potential, Mitochondrial; Mesenchymal Stem Cells; NADH Dehydrogenase; Okadaic Acid; Protein Synthesis Inhibitors; Signal Transduction; Staurosporine; Tumor Necrosis Factor-alpha; von Willebrand Factor; Wortmannin | 2009 |
Regulation of PI(3)K/Akt signalling and cellular transformation by inositol polyphosphate 4-phosphatase-1.
Topics: Animals; Apoptosis; Cell Proliferation; Cells, Cultured; Cycloheximide; Epidermal Growth Factor; Fibroblasts; Mice; Phosphatidylinositol 3-Kinases; Phosphoric Monoester Hydrolases; Proto-Oncogene Proteins c-akt; Signal Transduction; Staurosporine | 2009 |